Patients with placenta accreta have abnormally adherent placentas and are at risk for massive hemorrhage at delivery. We report 2 cases of cesarean hysterectomy in patients with placenta accreta. These patients were cared for by a multidisciplinary team consisting of a maternal fetal medicine ...

Placenta accreta is an abnormal adherence of placenta to the uterine wall without interposition of decidua basalis. Placenta percreta is the rarest form but may complicate the pregnancy with acute severe hemorrhage. We report a case of placenta percreta with multiple ...

Morbidly adherent placenta is a grave complication of pregnancy referring to a pathological adherence of placenta to uterine wall with a reported incidence of 1:2500 deliveries. Women with previous two caesarean sections and placenta previa are at greater risk and also those with previous ...

... the placenta peels away from the uterine wall Chromosomal abnormalities resulting from defects in the sperm or egg ...

... Title : Increasing Adherence to Follow-up of Breast Abnormalities in Low-Income Korean American Women: A Randomized Controlled Trial. ...

... TITLE: Increasing Adherence to Follow-up of Breast Abnormalities in Low-Income Korean American Women: A Randomized Controlled Trial ...

... TITLE: Increasing Adherence to Follow-Up of Breast Abnormalities in Low-Income Korean American Women: A Randomized Controlled Trial ...

... the military departments and agencies for Research Development Test and ... Increasing Adherence to Follow-Up of Breast Abnormalities in Low ...

... the military departments and agencies for Research Development Test and ... Increasing Adherence to Follow-Up of Breast Abnormalities in Low ...

Human placentas studied after normal and abnormal pregnancies require author attention to a number of variables derived from clinical chart review. We herein provide a Table listing many of the key variables that might be confounders for clinical studies of the human placenta. As Editors for Placenta, we ...

... BREAST CANCER, *WOMEN, ABNORMALITIES, INCOME, MAMMARY GLANDS ... Distribution Statement : APPROVED FOR PUBLIC RELEASE. ...

... and agencies for Research Development Test and ... to Follow-up of Breast Abnormalities in Low ... with a potential breast abnormality through the ...

... and agencies for Research Development Test and ... to Follow-Up of Breast Abnormalities in Low ... with a potential breast abnormality through the ...

Histopathological examinations of the placenta can reveal ischemic changes, inflammation of the placenta and fetal membranes, and changes indicating fetal anemia. These may be a threat to the fetus or cause later complications during childhood. Chronic villositis is caused by a maternal rejection reaction against fetal antigens. This rejection may cause ...

The placenta and umbilical cord play important roles in the development of the growing fetus. The placenta can be clearly identified by the 14th gestational week and should be evaluated during each obstetric ultrasound examination.This article reviews the formation of the placenta and its expected sonographic appearance throughout ...

Morbidly adherent placenta in a nulliparous woman is a rare phenomenon. An unusual case of a 20 years old primigravida presented in emergency with unstable haemodynamics and abdominal pain at 17 weeks of gestation is reported. She was found to have complete placental invasion and haemoperitoneum on laparotomy. Although there is an increased risk of ...

Abnormal attachment of the placenta (Placenta accreta, increta, and percreta) is an uncommon but potentially lethal cause of maternal mortality from massive postpartum hemorrhage. A 33-yr-old woman, who had been diagnosed with a placenta previa, was referred at 30 weeks gestation. On ultrasound, a complete type of ...

Abnormal attachment of the placenta (Placenta accreta, increta, and percreta) is an uncommon but potentially lethal cause of maternal mortality from massive postpartum hemorrhage. A 33-yr-old woman, who had been diagnosed with a placenta previa, was referred at 30 weeks gestation. On ultrasound, a complete type of ...

Placenta accreta refers to any abnormally invasive placental implantation. Diagnosis is suspected postpartum with failed delivery of a retained placenta. Massive obstetrical hemorrhage is a known complication, often requiring peripartum hysterectomy. We report a case of presumed placenta accreta in a patient ...

A low-sulfated chondroitin sulfate proteoglycan (CSPG) has been shown to be the receptor for the adherence of Plasmodium falciparum-infected red blood cells (IRBCs) in human placenta. Recently, hyaluronic acid (HA) has been suggested as an additional receptor even though IRBC binding to HA and the presence of HA at locations where IRBCs ...

The foundation for adult health is laid in utero and requires a healthy placenta. A common manifestation of abnormal placental development is impaired fetal growth. While placental pathology is the final common denominator in many cases of fetal growth restriction, a variety of discreet lesions have been described involving both the maternal and fetal ...

ABSTRACT: INTRODUCTION: Placenta percreta is an obstetric emergency often associated with massive hemorrhage, leading to emergency hysterectomy. CASE PRESENTATION: We present the case of a 30-year-old African woman, gravida 7, para 5, with placenta percreta managed by an alternative approach: the placenta was left in situ, methotrexate ...

IntroductionPlacenta percreta is an obstetric emergency often associated with massive hemorrhage and emergency hysterectomy.Case presentationWe present the case of a 30-year-old African woman, gravida 7, para 5, with placenta percreta managed by an alternative approach: the placenta was left in situ, methotrexate was administered, and ...

... Racial/ethnic disparities in time to follow-up after an abnormal ... Have Medical Insurance Yes ... Table 2. Health Related Characteristics by Study Group ...

... Type of health insurance� Private 6 32% 0 0 ... Los Angeles, School of Public Health and Division ... abnormalities may contribute to disparities in breast ...

... list abnormalities that may include unusual cell shape, colour differences, flocculation, adherence of algae to test vessels, aggregation of algal cell ...

Placenta accreta is a relatively rare event, in which the placenta is abnormally implanted into the uterine myometrium. The most significant complication of abnormal placentation is bleeding, mainly during labor. The bleeding increases especially when manual lysis of the placenta is attempted. ...

BackgroundThe placenta is an important site for iron metabolism in humans. It transfers iron from the mother to the fetus. One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to distinguish placental dysfunction.MethodsIn the experimental study we used ...

Among 23 women who underwent diagnostic hysteroscopy after triple uterine artery ligation with or without hemostatic multiple square suturing for the management of postpartum hemorrhage (PPH), five had abnormal findings. Endometritis was statistically significantly associated with abnormal diagnostic hysteroscopy findings. Twelve patients developed ...

Under laboratory conditions and in clinical experiments, bacterial collagenase has proven to be effective in hydrolyzing placenta and detaching cotyledon from caruncle in the bovine species. Laboratory studies in which placental samples were incubated with collagenase have also demonstrated that collagenase is 3.7 times more effective in hydrolyzing equine ...

We report on a woman who gave birth to dichorionic diamniotic twins with a birthweight discordancy of 30%. Her placenta exhibited characteristic features. The placental villous tissues were completely separated, but there was marked vascular communication between the two placentas. The lighter twin received less blood than the heavier twin via these ...

ObjectiveThe cause of preeclampsia remains unknown and the diagnosis can be uncertain. We used proteomic-based analysis of urine to improve disease classification and extend the pathophysiological understanding of preeclampsia.Study designUrine samples from 284 women were analyzed by mass spectrometry-based proteomics (SELDI). In the exploratory phase, 59 samples were used to extract the proteomic ...

to the external stimuli and experience. Critical periods are seen in many animals and in many sensory systems the physiological concentrations of neuromodulators, which may lead to abnormalities in the development of a fetus rupture, cerebral ischemia and death. Cocaine can rapidly diffuse across placenta to the fetus and cause

Normal function of the placenta is pivotal for optimal fetal growth and development. Fetal programming commonly is associated with placental dysfunction that predisposes to obstetric complications and suboptimal fetal outcomes. We consider several clinical phenotypes for placental dysfunction that likely predispose to fetal programming. Some of these reflect ...

OBJECTIVE: We sought to review the risks of placenta accreta, increta, and percreta, and provide guidance regarding interventions to improve maternal outcomes when abnormal placental implantation occurs. METHODS: Relevant documents were identified through a search of the English-language literature for publications including ?1 of the key words "accreta" ...

Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta. Therefore, we sought to determine the relationship between the imprinting of insulin-like growth factor II (IGF-II) in ...

... Type of health insurance Private 5 45% 0 0 ... Korean American community Clinics: Koryo Health Foundation & ... may contribute to disparities in breast ...

In most pregnancies the chromosomal complement detected in the fetus is also present in the placenta. The detection of an identical chromosomal complement in both the fetus and its placenta has always been expected as both develop from the same zygote. However, in approximately 2% of viable pregnancies studied by chorionic villus sampling (CVS) at 9 to 11 ...

In first-trimester chorionic villus sampling (CVS) for prenatal diagnosis, abnormal chromosomal findings, such as mosaicism, trisomies, or suspect abnormal karyotypes, are found more frequently than at amniocentesis. The fact that these chromosomal abnormalities do not always reflect the fetal karyotype but may be restricted to the ...

Hypertrophic placenta, or placentomegaly, has been reported in cloned cattle and mouse concepti, although their placentation processes are quite different from each other. It is therefore tempting to assume that common mechanisms underlie the impact of somatic cell cloning on development of the trophoblast cell lineage that gives rise to the greater part of fetal ...

Objective: To determine the ultrastructural changes of the placenta in women with pre-eclampsia and eclampsia compared to the placenta of normotensive patients. Study Design: Comparative descriptive study. Place and Duration of Study: Obstetrics Unit of North Colombo Teaching Hospital, Ragama, Sri Lanka in 2004. Methodology: Placentae ...

PURPOSE.: To evaluate the abnormal sonographic (US) findings in patients with placenta previa and bleeding. METHODS.: A total of 182 cases of singleton pregnancies with placenta previa were reviewed. The US findings including the type of placenta previa, placental location, presence of placenta ...

Infection with Plasmodium falciparum during pregnancy results in the adherence of infected red blood cells (IRBCs) in placenta, causing pregnancy-associated malaria with severe health complications in mothers and fetuses. The chondroitin 4-sulfate (C4S) chains of very low-sulfated chondroitin sulfate proteoglycans (CSPGs) in placenta ...

Complete Genome Sequence of Crohn's Disease- Associated Adherent-Invasive E. coli Strain LF82�riologie, Clermont-Ferrand, France Abstract Background: Ileal lesions of Crohn's disease (CD) patients are abnormally. (2010) Complete Genome Sequence of Crohn's Disease-Associated Adherent-Invasive E. coli Strain LF82. PLo

In order to investigate the effect of placental size on fetal intrauterine growth retardation (IURG), we examined the morphology and alterations in the expression of glucose transporter in the placentas of rats exposed to 6-mercaptopurine (6-MP). 6-MP was administered orally at 0 and 60 mg/kg/day on gestation day (GD) 9, 11, 13 or 15, and the placentas ...

The objective of this study was to investigate the hypothesis that the altered epigenetic mechanisms that regulate IGF2 imprinting in placentas from fetal growth restricted (FGR) pregnancies affect IGF2 expression leading to impaired fetal growth. We investigated gene transcription, genotyping and the methylation patterns of IGF2 from 31 and 17 placentas ...

A fundamental step in embryonic development is cell differentiation whereby highly specialised cell types are developed from a single undifferentiated, fertilised egg. One of the earliest lineages to form in the mammalian conceptus is the trophoblast, which contributes exclusively to the extraembryonic structures that form the placenta. Trophoblast giant cells (TGCs) in the ...

We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an ...

Congenital anomalies caused 3.43 perinatal deaths/1000 births, as reported in a large prospective study. At all gestational ages the mortality rates progressively increased when gravidas smoked more than 10 cigarettes/day. An excessive death rate was also found in males, in offspring of mothers over 39 years of age, and in women of low socioeconomic status. Placentas ...

Placenta previa is a condition of pregnancy when the placenta implants in the lower part of the uterus, ...

Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA_PAM). We report here that VSA_PAM-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently ...

Practical application of animal cloning by somatic cell nuclear transfer (SCNT) has been hampered by an extremely low success rate. To address whether placental dysfunction in SCNT causes fetal loss during pregnancy, we have used a global proteomics approach using 2-DE and MS to analyze the differential protein patterns of three placentae from the afterbirth of cases of ...

Placentation starts with the formation of a spheroidal trophoblastic shell surrounding the embryo, thus facilitating both implantation into the uterine stroma and contact with maternal blood. Although it is known that diabetes increases the placental size and weight, the mechanisms responsible for this alteration are still poorly understood. In mammals, cellular proliferation occurs in parallel to ...

Objective:To determine the effects of fetal sex on aromatase and androgen receptor (AR) expression in the placenta of normal and preeclamptic pregnancies.Study Design:Placentae from preeclamptic (five female and six male fetuses) and healthy pregnancies (seven female and seven male fetuses) were examined by immunofluorescence, western blotting and ...

This study investigated the differentiation of placenta-derived adherent cells (PDACs) into insulin-producing cells (IPCs). PDACs were cultured and the cells characterized by analysis of cell surface markers using flow cytometry. The PDACs were then treated with induction media containing basic fibroblast growth factor (bFGF) and beta-mercaptoethanol ...

Production of cloned mammals by somatic cell nuclear transfer (SCNT) is associated with functional and structural abnormalities of placentation and with abnormal fetal development. A proteomic analysis was performed in domestic cats (Felis catus) to compare cloned term placentas (CTP) obtained from cesarean section (CS) to control ...

Fetal thrombotic vasculopathy (FTV) is a placental lesion characterized by regionally distributed avascular villi and is often accompanied by upstream thrombosis in placental fetal vessels. Previous studies, using preselected populations, have shown associations of this lesion with adverse neurodevelopmental outcomes and potentially obstructive lesions of the umbilical cord. We investigated the ...

Vasculogenesis and angiogenesis are regulated by the capacity of endothelial cells to adhere to each other and form new tubes. The presence and role of junctional adhesion molecules during physiological vasculogenesis is unknown. Using ultrastructural and immunocytochemical approaches, we compared the junctional phenotype of developing vessels of the first-trimester human ...

ObjectivePlacental mesenchymal dysplasia (PMD) is an uncommon vascular anomaly of the placenta characterized by mesenchymal stem villous hyperplasia. Its main sonographic features is a thickened placenta with hypoechoic areas, and an accurate sonographic diagnosis is challenging. The aim of this study was to report two cases of PMD, and discuss the ...

Loss of imprinting (LOI) is the gain of expression from the silent allele of an imprinted gene normally expressed from only one parental copy. LOI has been associated with neurodevelopmental disorders and reproductive abnormalities. The mechanisms of imprinting are varied, with DNA methylation representing only one. We have developed a functional transcriptional assay for LOI ...

The purpose of this study was to evaluate the significance of histological examination of the placenta during routine post-mortem examination of foetal, perinatal and early neonatal deaths with particular reference to the cause of death. Three hundred (300) placentas were examinated over a period of three years (1988-1991). The clinical history, autopsy ...

We present an extremely rare case of partial molar pregnancy with a chromosomically and phenotypically normal embryo and review of the literature. A 31-year-old nulliparous was referred to us at 30 weeks of gestation due to absence of fetal movements and subsequent ultrasound examination revealed intrauterine demise. Prenatal amniocentesis due to raised maternal serum ?-fetoprotein had shown a ...

Preeclampsia (PE) is a severe hypertensive disorder associated with pregnancy; despite substantial research effort in the past several years, the etiology of PE is still unclear. The role of epigenetic factors in the etiology of PE, including DNA methylation, has been poorly characterized. In the present study, we investigated global DNA methylation as well as DNA methylation of the paternally ...

Trophoblastic cell fusion is one essential step of the human trophoblast differentiation leading to formation of the syncytiotrophoblast, site of the numerous placental functions. This process is multifactorial and finely regulated. Using the physiological model of primary culture of trophoblastic cells isolated from human placenta, we have identified different membrane ...

Nuclear magnetic resonance spectroscopy is a powerful method of investigating the relationship between metabolism and function in living tissues. We present evidence that the phosphorus 31 spectra of myometrium and placenta are functions of physiologic state and gestational age. Specific spectroscopic abnormalities are observed in association with ...

Tungsten films were plasma-deposited using an abnormal glow discharge through a mixture of tungsten hexafluoride, hydrogen, and argon. The films adhered well to silicon, silicon dioxide, gallium arsenide, and aluminum substrates placed directly on the dis...

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Conservative treatment for placenta accreta has recently been popularly accepted even though serious postpartum hemorrhage, resulting in maternal death, may occur. We report a case of placenta previa accreta with cervical involvement resulting in tenacious postpartum hemorrhage. A 28-year-old pregnant woman, gravida-2 para-1, who had undergone a previous ...

BackgroundThe guinea pig is an attractive model for human pregnancy and placentation, mainly because of its haemomonochorial placental type, but is rather small in size. Therefore, to better understand the impact of body mass, we studied placental development in the capybara which has a body mass around 50 kg and a gestation period of around 150 days. We paid attention to the development of the ...

In order to determine the cause of a perinatal death it is important to correlate the postmortem findings with the clinical histories of both mother and infant. The postmortem examination of a newborn infant differs from that of an adult in a number of ways, especially in the method of removal and dissection of the brain, the examination of the cervical spine, the dissection of the cardiovascular ...

Hydatidiform mole (HM) is an abnormal development of the placenta with hyperproliferative trophoblast. Biparentally inherited HM (BiHM) have normal diploid biparental inheritance and are not androgenetic. Linkage using consanguineous pedigrees of women with BiHM refined a major locus to chromosome...

The present report describes a female patient, 33 weeks pregnant, who demonstrated complicated abnormal placenta formation and fetal distress, and who presented with an acute type A aortic dissection. The patient underwent an immediate cesarean section and hysterectomy followed by a successful emergency surgical aortic repair, thereby obtaining a favorable ...

Aim:? We evaluated the efficacy of uterine artery embolization (UAE) for controlling postpartum hemorrhage (PPH). Materials and Methods:? Between January 2008 and December 2009, 23 women with intractable PPH underwent UAE. Specific diagnoses included uterine atony (n?=?10), placenta accreta (n?=?8), puerperal hematoma (n?=?2) and placental polyp (n?=?3). Results:? Of 10 ...

A method of irradiating placental tissue separate from embryonic tissue is described. Rat embryos and placental tissue were selectively irradiated on the l2th gestational day and examined on the l6th gestational day for growth retardation, fetal mortality, and congenital malformations. The maternal organism received no irradiation in this ex periment; only the ...

BackgroundDomestic goats (Capra hircus) are a natural and experimental host of scrapie and bovine spongiform encephalopathy, the transmissible spongiform encephalopathies (TSE) of sheep and cattle. Goats are also susceptible to experimental infection with the agents of TSEs of deer and elk (chronic wasting disease) and humans (Creutzfeldt Jakob disease). Distribution of ...

This is a retrospective analysis of sensitivity and specificity of clustered placental basal plate multinucleate trophoblastic giant cells for various clinical conditions and placental lesions associated with fetal and placental hypoxia. Selected clinical and placental parameters of 375 consecutive cases of placentas with clusters of multinucleate trophoblastic giant cell (at ...

Objective: To assess risk factors for postpartum hemorrhage (PPH) and the extent to which changes in those risk factors may explain the rising incidence of PPH recently reported from industrialized countries. Methods: We carried out a hospital-based cohort study of 103 726 consecutive deliveries from January 1, 1978, to January 31, 2007, from the computerized medical records of a tertiary-care ...

Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that include increased disease severity in pregnant women, decreased fetal viability, intra-uterine growth retardation, low birth weight and infant mortality. The physiopathology of malaria in pregnancy is difficult to scrutinize and attempts were made in the past to use animal models for pregnancy malaria ...

Herpesvirus infection of placenta may be harmful in pregnancy leading to disorders in fetal growth, premature delivery, miscarriage, or major congenital abnormalities. Although a correlation between human herpesvirus 8 (HHV-8) infection and abortion or low birth weight in children has been suggested, and rare cases of in utero or perinatal HHV-8 ...

Herpesvirus infection of placenta may be harmful in pregnancy leading to disorders in fetal growth, premature delivery, miscarriage, or major congenital abnormalities. Although a correlation between human herpesvirus 8 (HHV-8) infection and abortion or low birth weight in children has been suggested, and rare cases of in utero or perinatal HHV-8 ...