The aetiology of profound hearing loss in children is complex and multifactorial. Congenital inner ear abnormality is a major cause of hearing loss in children. CT temporal bone imaging is the modality of choice in the investigation of hearing loss. Recognising the congenital abnormalities of the inner ear guides the clinician's ...

... We have been studying a family of proteins ... NEOPLASMS, CHROMOSOMES, IMMUNOASSAY, ABNORMALITIES, SKELETON, HIGH SENSITIVITY ...

With quantitative sacroiliac joint scintigraphy (QSS), sacroiliac joint-to-sacrum (SIS) ratios greater than or equal to 1.40 are abnormal for our method. High SIS ratios are associated with roentgenographically appreciated sacroiliitis and with early clinically evident sacroiliitis. Although highly sensitive, QSS ...

... follows: 1. Group A showing osteoporosis. 2 ... osteomyelitis). The most common bone abnormality was that of osteoporosis. This ...

The book is divided into seven major sections on Decrease in bone density, Osteosclerosis, Localized lesions in bone, Lesions affecting the epiphyses, Abnormalities in the region of the metaphysis, Periosteal reactions, and Abnormalities in size and modelling of bone.

Cathepsin K, a papain-like cysteine protease, is highly expressed in osteoclasts and plays a critical role in bone resorption. Dysfunction of the enzyme leads to various skeletal abnormalities. The recent knowledge that the collagenolytic activity of cathepsin K depends on interactions with bone and ...

Although the detection efficiency of liver scanning for liver metastases is low (70 to 80 percent) it is still more sensitive than the usual clinical and laboratory measurements in detecting hepatic metastases. A recent survey indicated also that the bone scan is the diagnostic method of choice in skeletal evaluation. Although the bone scan is ...

Langerhans cell histiocytosis is characterized by abnormal accumulations of large mononuclear cells forming granulomas in various organs mainly in the lung, bone, or skin. Adult pulmonary Langerhans cell histiocytosis is rare and almost always associated with cigarette smoking; combination with lung and bone simultaneous involvement is ...

Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, leading to increased ...

Alkaline phosphatase prepared from bone and studied in vitro in relation to the effect of fluoride was relatively insensitive to fluoride. Concentrations of fluoride in excess of 10/sup -2/ M were required for inhibition. Experiments with dairy heifers and cows indicated a close correlation between fluoride ingested, fluoride content of the bone, osseous ...

With increased life expectancy, thalassaemic bone disease including osteopenia osteoporosis syndrome (OOS) is a major cause of bone pain and fragility fractures especially of the lumbar spine, which may be found in 70-80% adult patients with beta-thalassaemia worldwide, accounting for significant bone morbidity. The causes of OOS in ...

Current strategies for detecting chromosome abnormalities in MDS/AML include FISH or traditional cytogenetics. MLPA detects abnormalities in multiple loci simultaneously, with higher resolution and throughput. Peripheral blood from 50 healthy subjects was used to establish probe-specific reference ranges, increasing MLPA sensitivity and specificity. MLPA ...

Since the beginning of cytogenetics, there has been a constant improvement of chromosomal culture and banding techniques. In 1976, Yunis described a high chromosomal resolution technique (HRC), that permits the detection of subtle chromosomal abnormalities. The present work, reports the results obtained when HRC was applied to the study of chromosomal ...

Skeletal limb abnormalities refer to a variety of bone structure problems in the arms or legs (limbs). ... Skeletal limb abnormalities are most often used to describe defects in the legs or arms that are associated with your genes ...

Paget's disease is a chronic disorder of bone remodeling, characterized by an abnormal increase of osteoclast and, hence, osteoblast activity. The imbalance of bone turnover results in the formation of unhealthy and fragile bone. It also leads to impairment of adjacent joints and to a risk of various complications. ...

A 64-year-old man visited our hospital, due to right shoulder pain and fever. Chest X-ray revealed a well-defined tumor in the upper field of the left lung, and the histological diagnosis was adenocarcinoma. Bone scintigraphy demonstrated abnormal accumulation localized in the right shoulder joints. Although bone metastasis was ...

Emaciated human patients have changes in the fat content in medullary bone that are consistent with serous atrophy of the bone marrow histologically. Serous atrophy has been identified at postmortem examination in horses; however, the magnetic resonance (MR) characteristics have not been documented. Herein we describe the abnormalities ...

Two bison calves were submitted to the Western College of Veterinary Medicine to confirm suspected copper deficiency. In addition to clinical signs, there were pathologic changes in the cartilage and subchondral bone of several joints. Water analysis indicated high levels of sulfate in the drinking water, contributing to a secondary copper ...

... Accession Number : ADD117511. Title : On the Distribution of Martensite with Abnormally High Tetragonality,. Corporate Author : ...

Magnetic resonance imaging (MRI) is very sensitive for the detection of marrow abnormalities. Bone marrow edema on MRI has been defined as an area of low signal intensity on T1-weighted images, associated with intermediate or high signal intensity findings on T2-weighted images. The bone marrow edema pattern is a ...

Results are presented from a study of the prevalence of middle and external ear disorders in coal miners who work underground. The study followed from an earlier NIOSH report (1976) that indicated a possibly large number of otoscopic abnormalities in this population of workers. Otoscopic examinations, pure tone air- and bone-conduction audiometry tests, ...

... of anemia that don�t respond to treatment (refractory), myelodysplastic syndrome associated with chromosome abnormality, and unclassified ...

The nuclear DNA content of 38 malignant and 25 benign bone tumours was measured by flow cytometry. The specimens were taken either from biopsies or from surgical specimens. Seventeen of 26 primary malignant bone tumours were aneuploid, 15 had a single aneuploid DNA content, and 2 had a biclonal abnormality. Thirteen of 15 osteosarcomas ...

Bone marrow edema is seen in osteoarthritis, avascular necrosis, and other clinical conditions including the bone marrow edema syndrome. Bone marrow edema is associated with bone pain and may be related to the pathophysiology of osteoarthritis. Our hypothesis is that bone marrow edema is ...

an older person What Abnormal Results Mean Lumbosacral spine x-rays may show: Abnormal curves of the spine Abnormal wear on the cartilage and bones of the lower spine, such as bone...

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is considered to be a systemic disorder that associated with fracture, cardiovascular disease, and mortality. Because the early initiation of appropriate therapy may prevent or ameliorate the mineral and bone disorder that developed in late CKD, the ability to define the pathophysiologic process ...

Craniofacial fibrous dysplasia (CFD) may show arterial displacement or increased uptake during arterial, capillary, venous, and blood-pool phases of radionuclide angiography. Extensive single or multiple areas of uptake are present on brain and bone images. These findings are probably due to the highly vascular bone often found in CFD. ...

Twenty-one neonates suspected of having acute osteomyelitis were studied by technetium-99m phosphate radiopharmaceuticals. Of the ten infants subsequently proven to have osteomyelitis involving 20 sites in all, only six sites (31.5%) were abnormal by bone imaging. Fifty-eight percent were normal and 10.5% equivocal. These poor results are contrary to the ...

Fractures are common in patients with chronic kidney disease (CKD) and associated with substantially high morbidity and mortality. Bone mass measurements are commonly used to assess fracture risk in the general population, but the utility of these measurements in patients with CKD, and specifically among those on hemodialysis, is unclear. This review will ...

Gelatinous transformation of the bone marrow is a rare disease characterised by a focal marrow hypoplasia, fat atrophy and accumulation of extracellular mucopolysaccharides abundant in hyaluronic acid, which is often associated with extreme malnutrition and weight loss. There are only two reports describing its association with systemic lupus erythematosus (SLE). One described ...

GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass. Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues. The availability ...

GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass. Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues. The availability ...

Eight sports horses with unilateral (4) or bilateral (3) forelimb or unilateral hindlimb (1) lameness had subtle radiologic abnormalities of the subchondral bone of the sagittal groove of the proximal phalanx associated with moderate or intense increased radiopharmaceutical uptake. High-field or low-field magnetic resonance (MR) ...

The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow ...

Bones from 15 individuals who carried Ra/sup 226/ for many years have been examined by microradiographic and autoradiographic techniques. Some of these subjects were radium dial painters, who may have had mesothorium in addition to their measured radium burden. Others were treated with radium therapeuticaily, of which three were given multiple injections of pure ...

Transient bone marrow edema of the hip is characterized by moderate homogeneous low MR signal intensity with ill-defined margins that involves at least a portion of the femoral head. Spin echo T1-weighted images are helpful to exclude other underlying diseases (tumor, infection, necrosis from systemic origin�), for which marrow edema is secondary or no epiphyseal in ...

High-resolution direct and synchronization culture techniques for chromosome analysis of leukemic bone marrow cells can now be utilized. In this article, three different techniques are quantitatively compared for their consistency in successful cytogenetic analysis, reliability in the detection of clones with chromosomal abnormalities, ...

We developed a computer-aided diagnostic (CAD) scheme for assisting radiologists in the detection of asymmetric abnormalities on a single whole-body bone scintigram by applying a contralateral subtraction (CS) technique. Twenty whole-body bone scans including 107 abnormal lesions in anterior and/or posterior images ...

Effects of irradiation of bone from internally deposited radioisotopes are considered. Problems encountered in measurement of the absorbed radiation dose and assessing damage in bone are also considered. The calculated accumulated dose can only be approximate, and to estimate it over a long period of time a very large number of observations have ...

Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of fragility fractures. Twin and family studies have shown high heritability of bone mineral density (BMD) and other determinants of fracture ...

Renal osteodystrophy occurs early during loss of kidney function. There are 26 million American patients with chronic kidney disease (CKD) and almost all patients with CKD-5 have abnormal bone histology. Six hundred thirty bone biopsies from adult CKD-5 patients on dialysis were evaluated by histomorphometry and analyzed using the ...

High-resolution computed tomography (CT) was used to examine 12 patients with temporal bone trauma. The CT findings were correlated with the clinical signs and symptoms (hearing loss, facial nerve dysfunction) and with the operative findings in the 5 patients who underwent surgery. CT was able to demonstrate ossicular chain disruption or fractures causing ...

Cartilage-associated protein (CRTAP) is an essential cofactor for the proper post-translational chain modification and collagen folding. CRTAP mutations lead in mice (Crtap?/? mice) and humans (OI type VII) to a severe/lethal osteochondrodystrophy; patients have fractures at birth, deformities of the lower extremities and impaired growth. The consequences of CRTAP deficiency on intrinsic ...

With the awareness of osteoporosis as a major health problem for an aging population, there is great interest in early recognition and treatment of abnormal bone loss. Effective prevention of bone loss has to occur prior to the occurrence of irreparable damage. Standard radiographic procedures are not sensitive enough for the task. ...

An 18 year old man with fibrous dysplasia of bone and several endocrine abnormalities was investigated. Laboratory tests showed high levels of prolactin, TSH and GH and low levels of testosterone and LH. TRH and GnRH showed normal responsiveness of the pituitary in spite of the high hormonal levels. The circadian ...

Five patients with a histologic diagnosis of chondrosarcoma are discussed, with special attention to evaluation of these lesions by cranial computed tomography (CCT). These patients displayed findings that are highly suggestive of chondrosarcoma: high absorption abnormality on plain CCT scans, contrast enhancement, and osteolytic ...

A prospective study of 6.2 patients evaluated the usefulness of bone and gallium scintigraphy prior to definitive surgery for soft tissue masses in the extremities. Bone scans in 62 patients included blood pool images in 40. Ga-67 imaging was done in 61. Surgery disclosed 30 soft tissue sarcomas, 25 benign tumors, and 7 negative reexplorations of ...

Essential thrombocythemia (ET), in an 11-year-old dog was characterized by persistently high platelet counts range, 4.19 X 10(6)/microliters to 4.95 X 10(6)/microliters, abnormal platelet morphology, marked megakaryocytic hyperplasia in the bone marrow, absence of circulating megakaryoblasts, and history of splenomegaly and ...

CASE REPORT: Congenital disfiguring malformations are rare and usually have a multifactorial aetiology. Here we report on the ocular manifestations seen in a patient with Proteus syndrome. The retina showed retinal dysgenesia, retinal pigmentary abnormalities and optic nerve hypoplasia. Other abnormalities included strabismus and high ...

ABSTRACT: Hydatid disease is common in many parts of the world, and causes considerable health and economic loss. This disease may develop in almost any part of the body.Bone involvement is often asymptomatic, and its diagnosis is primarily based on radiographic findings. A whole body bone scan is able to show the extent and distribution of lesions.We ...

Hydatid disease is common in many parts of the world, and causes considerable health and economic loss. This disease may develop in almost any part of the body.Bone involvement is often asymptomatic, and its diagnosis is primarily based on radiographic findings. A whole body bone scan is able to show the extent and distribution of lesions.We describe an ...

Renal osteodystrophy occurs early during loss of kidney function. There are 26 million American patients with chronic kidney disease (CKD), and almost all patients with CKD stage 5 have abnormal bone histology. Six hundred and thirty bone biopsies from adult CKD-5 patients on dialysis were evaluated by histomorphometry and analyzed ...

A guided biopsy technique has been developed for evaluation of solitary bone abnormalities, identified by gallium 67 or technetium 99 bone scans, in patients with normal or ambiguous x-ray findings. Continuous gamma camera monitoring is used to guide staining of the bone abnormality and ...

Twenty-eight pressure sores were evaluated prospectively. Osteomyelitis was reported histologically in nine of 28 bones and pressure-related changes were reported in 14 bones. Roentgenograms suggested the presence of osteomyelitis in four instances of histologically proved osteomyelitis. Technetium Tc 99m medronate bone scans were ...

Technetium-99m sulfur colloid scintigraphy was performed prospectively in 12 infants and children with autosomal recessive osteopetrosis, to correlate the appearance of bone marrow stores with advancing age. Baseline images were obtained in all patients, and one to five follow-up images were obtained in eight patients after they began therapy with calcitriol, interferon-gamma, ...

Osteogenesis imperfecta type I (OI-I) represents the mildest form of OI. The collagen I mutations underlying the disorder can be classified as quantitative mutations that lead to formation of a decreased amount of normal collagen or qualitative mutations where structurally aberrant collagen chains are generated. However, the phenotypic consequences of a particular mutation are not well understood. ...

... is the abnormal growth of bone of the middle ear. This bone prevents structures within the ear ... The ear has three main parts: the outer, middle, and inner ear. Sound waves enter through the ...

We report a case of hypoplastic myelodyplastic syndrome (MDS) (refractory anemia (RA)) in which sustained trilineage haematological response and persistent disappearance of an abnormal chromosome clone were achieved after treatment with combination therapy of cytokines (granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Epo)) and methylprednisolone (mPSL) pulse ...

Erlenmeyer flask bone deformity (EFD) is a long-standing term used to describe a specific abnormality of the distal femora. The deformity consists of lack of modeling of the di-metaphysis with abnormal cortical thinning and lack of the concave di-metaphyseal curve resulting in an Erlenmeyer flask-like appearance. Utilizing a literature ...

According to the new KDIGO (Kidney Disease Improving Global Outcomes) guidelines, the term of renal osteodystrophy, should be used exclusively in reference to the invasive diagnosis of bone abnormalities. Due to the low sensitivity and specificity of biochemical serum markers of bone remodelling,the performance of ...

Twenty-two painful hip prostheses were studied prospectively with plain radiography, aspiration and arthrography, Tc-99m phosphate bone imaging, and gallium imaging to evaluate loosening, infection, or both and to compare the accuracy of these modalities. Fifteen prostheses were revised yielding 14 loose femoral and eight loose acetabular components. Five proved to have ...

A systematic method for comprehensive visualization of the temporal bone structures using thin-section, high-resolution computed tomography (CT) was developed. In relation to the anthropologic baseline (0 degrees), four separate tomographic planes of 0 degrees, 30 degrees, 70 degrees, and 105 degrees were each found to optimize different aspects of ...

A systematic method for comprehensive visualization of the temporal bone structures using thin-section, high-resolution computed tomography (CT) was developed. In relation to the anthropologic baseline(0/sup 0/), four separate tomographic planes of 0/sup 0/, 30/sup 0/, 70/sup 0/, and 105/sup 0/ were each found to optimize different aspects of temporal ...

Carrageenan arthritis is associated with high-turnover bone loss. We sought to determine whether the bisphosphonate pamidronate can modify this effect of inflammatory arthritis. Sixty mature, New Zealand White rabbits were randomly assigned to five groups: normal; normal with a therapeutic dose of pamidronate (300 microg/kg/day, administered ...

Two siblings displaying macrocrania and multiple skeletal deformities, as well as cardiomegaly, had high levels of serum alkaline phosphatase, and markedly increased urinary hydroxyproline excretion. The radiological findings of chronic familial hyperphosphatasemia, which are typical of a rare bone-remodeling disease, are presented. Scintigraphy disclosed ...

... 2002) estimated that about 2% of the koalas (Phascolarctos cinereus) examined at his veterinary lab at the University ... ...

ObjectiveTo document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children.Study designCorrespondents of the French Society of Childhood Malignancies were asked to notify all cases of aggressive vascular abnormalities of bone diagnosed ...

Eighteen patients with multiple myeloma were studied using radiographs of the skeletal system, technetium phosphate bone scans, and gallium-67 scintigraphy. A total of 94 sites were used as the basis for comparison in these 18 patients. Radiographic sensitivity on a patient basis was 94%, and was 82% on a site basis. Bone scans were positive in 78% of ...

Magnetic resonance imaging (MRI) is gaining increasing significance to study disease burden and progression in osteoarthritis. Bone marrow edema pattern has been identified as a typical MR finding associated with osteoarthritis. Histologically, bone marrow edema pattern is characterized by a mix of different pathologies, including bone ...

Four cases of ankylosing spondylitis are presented in which radionuclide bone studies indicated focal abnormalities of the spine. In three patients, the area of abnormal nuclide uptake corresponded to a site of pseudarthrosis, and in the fourth an acute fracture was present. As such focal lesions on bone scans are ...

Connexin43 (Cx43) has an important role in skeletal homeostasis, and Cx43 gene (Gja1) mutations have been linked to oculodentodigital dysplasia (ODDD), a human disorder characterized by prominent skeletal abnormalities. To determine the function of Cx43 at early steps of osteogenesis and its role in the ODDD skeletal phenotype, we have used the Dermo1 promoter to drive Gja1 ...

Context: Bone mineral density (BMD) is lower in young amenorrheic athletes (AA) compared to eumenorrheic athletes (EA) and nonathletic controls and may contribute to fracture risk during a critical time of bone accrual. Abnormal bone microarchitecture is an independent determinant of fracture risk and has not been ...

Osteopetrosis is a metabolic disorder with diminished bone resorption due to osteoclastic abnormality. It causes hard and brittle marble bone which fractures easily. Most of these fractures can be treated conservatively. Operative intervention when needed presents with unique technical challenges. While osteopetrotic hard ...

The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear ...

To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of ...

The incorporation of (/sup 14/C)glutamic acid into EDTA-soluble and -insoluble calvaria protein in vitro and (/sup 14/C)proline into EDTA-insoluble femur protein in vivo was determined in chicks fed inadequate and adequate levels of nonspecific nitrogen (glutamic acid). In each instance, the amount of amino acid incorporated into bone protein was reduced by the low level of ...

The consumption of bracken fern (Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. We investigated the cytogenetic effects of bracken-fern extracts (hexane extract-HE, ethanol extract-EE, hot water extract-HWE and cold water extract-CWE) on chromosomes of peritoneal and bone-marrow cells of Swiss mice. In ...

Enhanced imaging of early-stage bone abnormalities, such as primary tumors or metastases is highly required as the widely-used bone scan frequently lacks the desired sensitivity. Near IR (NIR) fluorescence imaging affords high contrast and enhanced sensitivity, as body tissue expresses minimal ...

The spread of carcinoma of the breast beyond the mammary tissue and regional lymph nodes most commonly occurs in the axial skeleton. The results of several investigations have shown that scintiscans are more accurate and sensitive than radiographs for the early detection of metastases to the bone. In recent years, bone seeking radionuclides, such as /sup ...

Background/aimsThe type II collagenopathies are a phenotypically diverse group of genetic skeletal disorders caused by a mutation in the gene coding for type II collagen. Reports published before the causative mutations were discovered suggest heritable bone dysplasias with skeletal malformations may be associated with a vitreoretinopathy.MethodsA retrospective notes search of ...

Bone mineral content (BMC) and width (W) have been measured in approximately 600 white women and 100 white men ranging from the teens to the 80s. Measurements were made using the /sup 125/I photon absorptiometric method at five pairs of contralateral sites with the arm in the prone position: the midshafts of the right and left radii and ulnae, the distal metaphyses of the ...

... that contribute to variation in bone cell response to ... Descriptors : *HIGH DENSITY, *BONES, STRESSES, POSITION(LOCATION), MECHANICAL ...

... the effects of these treatments on bone quality. ... ESTROGENS, *BREAST CANCER, *MORPHOLOGY(BIOLOGY), *BONES, DENSITY, THICKNESS ...

Strontium-87m bone scintigraphy was performed in 22 cases of bone metastasis or suspected bone metastasis of malignant tumors and 1 case of necrosis of the head of the femur. This mini-scanning method showed abnormalities in four out of six cases in which bone metastasis was demonstrated ...

Renal transplantation is the definitive treatment for many metabolic abnormalities of uremic patients, although it is only partially effective for renal osteodystrophy, which may interact with posttransplant renal osteopathy. Osteopenic-osteoporotic syndrome represents, together with fractures secondary to osteoporosis and osteonecrosis, the bone ...

c-Kit (CD117) is required for normal differentiation of osteoblasts from bone marrow stromal cells and for normal bone formation. Osteoblasts and adipocytes originate from a common progenitor cell, and a reciprocal relationship in differentiation of the two lineages is often observed. Therefore, the effects of abnormal c-kit signaling ...

Markers of bone turnover are becoming an important tool for practitioners in the management of osteoporosis. Therefore, it is essential to establish a reference database of the markers before using them in various clinical settings. A total of 785 individuals (37% males, 63% females) without apparent or suggested abnormalities affecting ...

Cemented total hip replacements generally fail after 10-20 years, often due to implant loosening from bone resorption. Bisphosphonates such as zoledronic acid (ZA) and pamidronate (PAM) are potent inhibitors of bone resorption. The local delivery of bisphosphonates via acrylic bone cement could decrease osteolysis and prolong implant ...

Skeletal abnormalities are a recognized component of Neurofibromatosis type I (NF1), but a generalized metabolic bone defect in NF1 has not been fully characterized thus far. The purpose of this study was to characterize at the densitometric, biochemical, and pathological level the bone involvement ...

This clinical book surveys the skeletal system as seen through radiological imaging. It emphasizing abnormalities, disease, and trauma, and includes vital information on bones, bone growth, and the cells involved in bone pathology. It covers many bone diseases and injuries which are rarely ...

The effects of high-dose irradiation on the morphology of haversian bone were studied, over a fifty-two-week period, in seventy-seven adult rabbits, after the administration of a single dose of radiation (therapeutic x-ray; twenty-five, fifty, or 100 gray) to one knee joint. The specimens of bone were examined with microangiography, ...

We examined parathyroid and skeletal function in 3-month-old mice expressing the null mutation for 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha(OH)ase(-/-)] and in mice expressing the null mutation for both the 1alpha(OH)ase and the calcium-sensing receptor [Casr(-/-)1alpha(OH)ase(-/-)] genes. On a normal diet, all mice were hypocalcemic, with markedly increased parathyroid hormone (PTH), ...

Global Kidney Disease Guideline Organization ; KDIGO has decided to express the abnormality in bone and mineral metabolism associated with chronic kidney disease (CKD) as CKD-Mineral Bone Disorder (CKD-MBD) . The term "renal osteodystrophy" is now only used for expressing bone pathological ...

... A genetic abnormality results in abnormal transport of amino acids in the kidney. The high levels of the amino acid cystine in the urine lead to stone ...

Although decreased hip range of motion has been detected in many soccer players with noncontact anterior cruciate ligament (ACL), it is not clear whether it is associated with bone spurs, capsular soft tissue stiffness or both. Our aim was to investigate abnormal radiographic findings in soccer players with limited hip range of motion and noncontact ACL ...

The application of tetracycline-based iliac bone histomorphometry to the study of the pathogenesis of osteoporosis has given conflicting results. Accordingly, we performed this procedure in 78 postmenopausal white women with one or more vertebral fractures identified according to rigorous criteria that excluded other causes of vertebral deformity and 66 healthy postmenopausal ...

Integrated hybrid single photon emission computerized tomography (SPECT)/computer tomography (CT) is a promising new diagnostic imaging modality for orthopedic patients. A high diagnostic yield is available from combining the detection of abnormal bone metabolism with SPECT, to the precise anatomical detail available in ...

No abstract.13:000015Basic biological reactions induced by exposure to lonizing radintion are reviewed in the light of contemporary opinions on the nature of nucleoproteins and complex systems of protein enzymes. The inflence of radiation on high-polymer nucleoproteims and nucleic acids and the radioinduced formation of abnormal crystals in ...

This article provides an overview of the current use of diagnostic imaging modalities in the evaluation of a heterogeneous group of disorders causing chronic anemias by impaired blood cell production (inherited bone marrow failure syndromes of childhood, aplastic anemia and myelodysplastic syndromes, ?-thalassemia) or increased blood cell destruction (sickle cell disease). ...