(1) abortifacient agents (43) prostaglandins (35) prostaglandins, synthetic (36) misoprostol (2 synthetic analog of natu- ral prostaglandin. Finally, the relationship between ,,misoprostol to the application in abortions: misoprostol is approved as an abortifacient in many countries, whereas (as stated

... Rofecoxib, Celecoxib, and Valdecoxib, and the traditional nonsteroidal anti-inflammatory agents (NSAIDs) Naproxen and Ibuprofen, as well as ...

Dr. J. B. Thrersch in personal communication (1) indicated his animal research has reported dimethyl acetamide to be an effective abortifacient agent; monomethyl formamide to be a potent teratogenic agent without abortifacient properties; and dimethyl for...

... Several nonsteroidal antiandrogens, such as nilutamide, bicalutamide, flutamide, and the corresponding metabolite hydroxyflutamide, have been ...

... Several nonsteroidal antiandrogens, such as nilutamide, bicalutamide, flutamide, and the corresponding metabolite hydroxyflutamide, have been ...

This report examines differences in risk of myocardial infarction and stroke (cardiovascular events) between the cyclooxygenase-2 (COX-2) inhibitors Rofecoxib, Celecoxib, and Valdecoxib, and the traditional nonsteroidal anti-inflammatory agents (NSAIDs) N...

Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicyclic acid, were either ineffective, or potentiated the ...

... or medical castration. Another common strategy involves the use of oral nonsteroidal antiandrogens. These agents prevent ...

The pharmacology, pharmacokinetics, clinical efficacy, contraindications and precautions, adverse effects, dosage, and cost of misoprostol are reviewed. Misoprostol is a synthetic analogue of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion and enhances mucosal resistance to injury. Misoprostol is extensively absorbed from the stomach and ...

The author discusses the validity of the claim that, in Antiquity, effective contraceptives and abortifacients were available, were widely used, and their use was responsible for the decline of population in certain periods. After reviewing the maneuvers and drugs used for those purposes, the author concludes that ancient physicians did not have at their disposal effective ...

Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-infammatory-induced gastric ulcers. Due to its uterotonic properties, it is also indicated in obstetrics for induction of labor and termination of pregnancy. In this last case, misoprostol is either used ...

Neosporosis is an infection of animals caused by an intracellular coccidian parasite, Neospora caninum, closely related to Toxoplasma gondii. The parasite is one of important abortifacient agents of bovine abortions worldwide. The aim of the study was to detect the prevalence of anti-Neospora antibodies in dairy aborting sheep from two eastern Slovak ...

Abstract Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e....

... have shown that women who use non-steroidal anti-inflammatory drugs (NSAIDs ... Also, how these agents prevent breastcancer is not understood. ...

... Co. Inc. 822 Oruvail is a registered trademark of Imperial Bank, As Agent (formerly registered to 823 Aventis Pharma SA). 824 Toradol ...

The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define...

The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the ...

Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A...

The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the acti...

The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The ...

Our earlier studies demonstrated that ibuprofen sensitizes prostate cancer cells to radiation in vitro and in vivo. The cytotoxic and radiosensitizing effects of NSAIDs were seen at concentrations that are higher than those that inhibit prostaglandin synt...

Our earlier studies demonstrated that ibuprofen sensitizes prostate carcinoma cells to radiation in vitro and in vivo. The cytotoxic and radiosensitizing effects of ibuprofen were seen at much higher concentration than that required to inhibit prostagland...

Following studies with ibuprofen that demonstrated radiation sensitization with prostate cancer cells in vivo and in vitro, we are examining the potential targets of cellular radio sensitization. We observed that NSAIDs inhibited the prostaglandin synthes...

Aspirin and the newer nonsteroidal anti-inflammatory drugs are the mainstay of basic therapy in rheumatoid arthritis and the other rheumatic diseases. Despite its many years of clinical use, the pharmacologic actions of aspirin are still not fully understood; those of many of the newer nonsteroidals may offer significant advantages in terms of long-term ...

Many non-steroidal agents prevent ovulation by acting on the nervous structures that control the secretion of gonadotrophins. Information on the neuroendocrine factors involved in the process of ovulation in mammals is presented in this paper and is then used as the background for explaining the mode of action of drugs which inhibit ovulation through an ...

1) Eric Blair (alias George Orwell) can rest easy in his grave, because birth control by governmentally imposed methods, such as incorporation of a contraceptive agent into drinking water, is totally unfeasible by 1984. 2) Fundamentally new birth control procedures in the female (for example, a once-a-month luteolytic or abortifacient ...

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most common pharmacological agents. They have three primary therapeutic properties including anti-inflammatory, anti-pyretic and analgesic effects. Seven NSAIDs were tested against two species of dermatophytes. Percentage inhibition was determined for effective agents. ...

To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction of morphine with different non-steroidal anti-inflammatory drugs (NSAIDs) using isobolographic analysis and the writhing test of mice. One of the possible ...

In reference to the presence of a list of abortifacients in a Greek manual of therapeutics or Arab origins (the Ephodia), the author reexamines the Oath of Hippocrates and its statement on abortion and abortifacients in the Hippocratic tradition as they were employed in Greek, Roman, Arab, and Byzantine cultures. PMID:17243320

Some indigenous plants reputedly possess antifertility properties when orally administered. Various extracts of some of these plants were used in an investigation to determine antifertility activity using a method which would ultimately detect anti-zygotic, blastocystoxic, anti-implantation or early abortifacient activity in adult female albino rats of proven fertility ...

A variety of agents are currently available that claim to either prevent, delay, or reverse cataracts associated with aging (senile cataracts), radiation, or diabetes and galactosemia (sugar cataracts). Senile cataract therapy includes formulation containing inorganic salts, nutritional supplements, natural product extracts, sulfhydryl, and sulfonic acid containing compounds ...

The incidence of prostate cancer has increased and effort is needed towards understanding mechanisms involved in development/progression of prostate cancer and developing new strategies for prevention/treatment. Studies suggested nonsteroidal anti-inflamm...

The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data ...

Nonsteroidal anti-inflammatory agents (NSAIAs), administered preoperatively and for three days postoperatively, were evaluated for reduction in the occurrence of venous complications following conscious sedation with intravenous diazepam. Patients receiving NSAIAs had significant reduction in overall incidence of postoperative venous complications when ...

Photosensitivity reactions associated with the use of prescription or over-the-counter drugs may be classified as phototoxic (caused by potentiation of solar energy by a drug) or photoallergic (in which the combination of a photosensitizing agent and light evokes a true cell-mediated hypersensitivity response). A case of a photoallergic response related to the use of piroxicam ...

Discusses management of common overuse disorders, which are often a result of repetitive stress. Reducing inflammation through icing, rest, and use of nonsteroidal anti-inflammatory agents is the primary treatment goal. Patients taking anti-inflammatories must be cautioned against returning to activity too soon because the medication's analgesic effect may ...

Rheumatoid arthritis is a common disease, for which every physician should have a sound approach. This paper details the global management of the disease. Guidelines are given for educating the patient and assessing the level of disease activity. Common questions about the indications and uses of non-steroidal anti-inflammatory drugs, local corticosteroid injections, ...

Brown syndrome is a challenging management problem. Congenital Brown syndrome may show spontaneous resolution, and conservative management is successful in around 75% of cases. Inflammatory acquired Brown syndrome may respond to peri-trochlear injection of steroids or oral non-steroidal inflammatory agents. Post-traumatic acquired Brown syndrome is not as ...

A new strategy for the catalytic enantioselective ?-arylation of N-acyloxazolidinones with chiral copper(II)-bisoxazoline complexes and diaryliodonium salts is described. The mild catalytic conditions are operationally simple, produce valuable synthetic building blocks in excellent yields and enantioselectivities, and can be applied to the synthesis of important nonsteroidal ...

Chronic benign pain usually requires treatment with drugs. Three main classes of drugs are used: opiates, non-steroidal anti-inflammatory drugs, and a miscellaneous group which includes psychoactive drugs and a variety of specific agents for individual conditions. The careful selection and combination of drugs, with adequate and appropriate dosage, will ...

Zilpaterol HCl is a beta-agonist feed additive that was approved for use to increase body weight gain and improve carcass composition in feedlot cattle. Because zilpaterol is a non-steroidal production enhancer, it has the potential to be used illicitly as a doping agent in species used for competit...

Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used as an opioid sparing agent for postoperative analgesia. Anaphylaxis due to intravenous diclofenac sodium is very rare. We report a case of anaphylactic reaction to IV diclofenac sodium, occurring postoperatively in a 25-year-old primigravida, the clinical features of which mimicked ...

Rheumatoid arthritis is the most common chronic inflammatory joint disease. To overcome joint inflammation and eventually induce disease remission, the physician must often use drugs that are more and more toxic. Indications, method of administration, and common adverse effects of non-steroidal anti-inflammatory drugs, local steroid injections, second-line ...

This review summarizes the current state of knowledge about drugs, other chemical substances, and toxins on blood pressure. Many classes of drugs, such as steroids, sympathomimetic amines, immunosuppressive agents, nonsteroidal anti-inflammatory agents, antidepressants, erythropoietin, substances of abuse and other ...

The effects of various clinically used anti-inflammatory agents on mouse skin tumorigenesis and aryl hydrocarbon hydroxylase (AHH) were investigated. Oxyphenbutazone, a nonsteroidal anti-inflammatory agent, inhibited 3-methylcholanthrene (MC) tumor initiation but was less effective than the steroidal anti-inflammatory ...

The management of migraine usually centers on two approaches: preventive and abortive therapy. Preventive therapy, designed to reduce the frequency, duration, and intensity of attacks, can be accomplished through a wide variety of medications. The most commonly used are beta-blockers, but calcium channel blockers, antidepressants, anticonvulsants, and nonsteroidal ...

A new class of non-ionic surface-active agents were synthesized by means of oxyethylation of ursodeoxycholic acid (UDOCh acid) with the application of modified generation of catalysts in the form of a model prodrug. Basic viscosity values ([eta], Meta, Ro, Robs., Omga) as well as the analytic level of hyrohilic-lipophilic balance HLB in the notation of Griffin, Davies and ...

The purpose in developing diclofenac sodium was to synthesize a nonsteroidal anti-inflammatory drug with high activity and outstanding tolerability. Factors considered were drug transport through biologic membranes, the atomic and spatial structure of the molecule, and the electronic structure. Based on analysis of other nonsteroidal anti-inflammatory ...

There is strong evidence from randomized clinical trials that the highly selective cox-2 inhibitors (coxibs), compared with placebo, cause an excess of serious cardiovascular events that are not mitigated by low-dose acetylsalicylic acid. Both Health Canada and the Food and Drug Administration have concluded that the excess cardiovascular events may be a �class effect� of all the ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used antipyretic agents that most probably exert their antifever effect by inhibiting cyclooxygenase (COX)-2. Thus, COX-2-selective drugs or null mutation of the COX-2 gene reduce or prevent fever. Acetaminophen is antipyretic and analgesic, as are NSAIDs, but it lacks the anti-inflammatory and ...

Model prescription for dental anti-inflammatory gels with carboxymethylcellulose sodium salt and non-ionic surfactants have been worked out. Viscosity parameters of 10 variant gel forms were investigated and an attempt on their interpretation was undertaken in relation to pharmaceutical availability of non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen sodium). ...

Migraine is a common and disabling disease of uncertain pathogenesis. Research on the trigeminovascular system, serotonin receptors, and substance P have provided clues to improving the pharmacotherapy of this disorder. Selective serotonin agonists, such as sumatriptan, dihydroergotamine, ergotamine tartrate, nonsteroidal anti-inflammatory drugs (NSAIDS), isometheptene mucate, ...

This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, ...

Emphasis during the past year has been on studies of the effects of potential promoting agents on radiation transformation, and of transformation by internal radionuclides emitting high LET radiation. We have also carried out a detailed investigation of the dosimetry of our alpha radiation source. Preliminary studies on the mechanisms of radiation transformation have been ...

In two retrospective clinical studies was investigated the influence of the modern non-steroidal antirheumatic drugs indometacin and diclofenac (Rewodina) on the thyroid gland and corresponding peripheral hormone parameters. Under longterm treatment with indometacin a moderate strumigenic effect could be observed, which could not clearly be proved under the diclofenac therapy. ...

Numerous systemically used drugs are involved in drug-induced glaucoma. Most reported cases of non-steroidal drug-induced glaucoma are closed-angle glaucoma (CAG). Indeed, many routinely used drugs that have sympathomimetic or parasympatholytic properties can cause pupillary block CAG in individuals with narrow iridocorneal angle. The resulting acute glaucoma occurs much more ...

Heavy menstrual bleeding is associated with increased local fibrinolysis. Antifibrinolytic agents have been used in women with menorrhagia with and without bleeding disorders, and have been demonstrated to decrease menstrual blood flow approximately 50% and improve quality of life. Most studies have been done with the antifibrinolytic agent tranexamic ...

Like in the adult population, nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used agents for their anti-inflammatory, anti-pyretic and analgesic effects in pediatrics. They are also used for some distinct indications in pediatrics such as Kawasaki disease, patent ductus arteriosus (PDA) closure, and Juvenile Idiopathic Arthritis (JIA). The ...

1. The effect of providing information about medicines by a short 'sales' interview between individual general practitioners and an 'academic representative' on prescribing was investigated. 2. The promotional campaign was designed to encourage a rational approach to prescribing of non-steroidal anti-inflammatory agents in an intervention group of 101 ...

Injuries sustained by horses during racing have been considered as an unavoidable part of horse racing. Many factors may be associated with the musculoskeletal injuries of Thoroughbred race horses. This study surveyed the amounts of nonsteroidal anti-inflammatory agents (NSAIDs) in injured horse's biological system (plasma) at Kentucky racetracks from ...

This study reports the isolation of a non-steroidal contragestative agent from the Sri Lankan marine red alga, Gelidiella acerosa. One-hundred grams of MeOH-CH2Cl2 (1:1) crude extract of G. acerosa was initially partitioned into hexane, CH2Cl2 and EtOAc, respectively, using the modified Kupchan scheme. At each separation step, all the resulting fractions ...

Misoprostol (Cytotec) is safe and effective for induction of labor, although it is not approved by the Food and Drug Administration (FDA) for use in pregnancy. In August 2000, the manufacturer of misoprostol warned against its use in pregnancy because of its abortifacient properties and cited reports of maternal and fetal deaths when misoprostol was used to induce labor, ...

The objective of the present study was to determine the presence of recognised abortifacient viruses such as porcine reproductive and respiratory virus (PRRSV), Aujeszky's disease virus (ADV), porcine parvovirus (PPV) and porcine circovirus type 2 (PCV2), in tissues from aborted fetuses and stillborn neonates in cases of late reproductive failure in swine. A total of 293 ...