Respiratory diseases are a major cause of mortality and morbidity worldwide. Current treatments offer no prospect of cure or disease reversal. Transplantation of pulmonary progenitor cells derived from human embryonic stem cells (hESCs) may provide a novel approach to regenerate endogenous lung cells destroyed by injury and disease. Here, we examine the therapeutic potential ...
PubMed Central
Acute kidney injury (AKI) contributes greatly to morbidity and mortality in critically ill adults and children. Patients with AKI who subsequently develop lung injury are known to suffer worse outcomes, compared to patients with lung injury alone. Isolated experimental kidney ischemia alters distal lung water ...
PubMed
Acute cellular rejection (ACR) is a common and important clinical complication following lung transplantation. While there is a clinical need for the development of novel therapies to prevent ACR, the regulation of allospecific effector T-cells in this process remains incompletely understood. Using the MHC-mismatched mouse orthotopic ...
... Background/Objectives: Smoke Inhalation victims are at high risk of lung inflammation and acute lung injury. ... Lung inflammation alters alveolar ...
DTIC Science & Technology
Hypertonic saline (HTS) resuscitation inhibits acute lung injury in animal models of shock, but some argue this may simply represent more efficient fluid resuscitation. Inflammatory mediators within mesenteric lymph have been identified as a link between splanchnic hypoperfusion and acute respiratory distress syndrome (ARDS). We ...
... planning, national and international politics, and ... acute lung disease, the appropriate ... OXIDES, *RESPIRATORY DISEASES, MODELS, FAILURE ...
... Descriptors : *HEALTH CARE MANAGEMENT, *COLON CANCER, *LUNG, *WOUNDS AND INJURIES, STEM CELLS, TRAUMA ...
... TITLE: Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation ...
... Title : Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation. ...
... Title : Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Injury. ...
BackgroundRat lung allograft rejection is mediated by collagen type V (col(V)) specific Th17 cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. We therefore tested if regulatory T cells from tolerant rats could suppress the Th17 mediated rejection in the syngeneic model ...
Complications of acute respiratory distress syndrome (ARDS) are common among critically ill patients infected with highly pathogenic influenza viruses. Macrophages and neutrophils constitute the majority of cells recruited into infected lungs, and are associated with immunopathology in influenza pneumonia. We examined pathological manifestations in models ...
... ENews Home > Lung Disease > Bronchitis, Acute Bronchitis Acute Bronchitis Acute bronchitis is an inflammation of the bronchial tubes, the ... by a variety of bacteria and viruses. Acute bronchitis can last from a few days to 10 ...
MedlinePLUS
Background: The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. Objectives: To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation.
National Technical Information Service (NTIS)
BACKGROUND: The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. OBJECTIVE: To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. SP...
The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. Objectives: To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. Specific aims...
Identifying whether or not neutrophils have a role to play in the early stages of acute lung epithelial injury brought about by inhalation of reactive substances continues to be a major area of investigation. In this study, the availability of circulating neutrophils was manipulated by treatment with either cyclophosphamide or rabbit antiserum against rat ...
Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute ...
Energy Citations Database
Flaxseed (FS) has high contents of omega-3 fatty acids and lignans with antioxidant properties. Its use in preventing thoracic X-ray radiation therapy (XRT)-induced pneumonopathy has never been evaluated. We evaluated FS supplementation given to mice given before and post-XRT. FS-derived lignans, known for their direct antioxidant properties, were evaluated in abrogating ROS ...
IntroductionActivated Protein C (APC), an endogenous anticoagulant, improves tissue microperfusion and endothelial cell survival in systemic inflammatory states such as sepsis, but intravenous administration may cause severe bleeding. We have thus addressed the role of APC delivered locally by inhalation in preventing acute lung injury from alveolar ...
During the period of the past two years, this laboratory has focused on the phenomenon of acute lung injury following the onset of systemic infection. To accomplish this we have used the pig to model acute lung injury. In our laboratory using the model as...
Acute lung injury in rats following airway delivery of CEES is associated with loss of distal lung barrier function (resulting in alveolar flooring) and an intense inflammatory response, which is lung-damaging. These acute lung injury parameters are atten...
Acute lung injury (ALI) is a complex condition associated with diffuse injury to the alveolar epithelial gas exchange surface, resulting in marked impairment in the ability to oxygenate blood. The goal of our application is to develop ventilatory and cell...
... effect of reducing lung injury present 12 ... Descriptors : *LUNG, * PHARMACOKINETICS, *RADIATION INJURIES, *RADIOPROTECTIVE ...
... Acute Lung Injury (TRALI), a serious pulmonary syndrome that can lead to death if ... TRALI is thought to be the third leading cause of transfusion related death. ...
Center for Biologics Evaluation and Research (CBER)
Rat lungs as affected by an acute exposure to an increased level of carbon dioxide in the ambient air
NASA Astrophysics Data System (ADS)
Page 1. Proeedings ~FL gof the .1Workshop on Acute Lung Injury and Pulmonary Edema 4-5 May 1989 a Aberdeen Proving Ground, Maryland I7 ...
... Title : Proceedings of the Workshop on Acute Lung Injury and Pulmonary Edema Held in Aberdeen Proving Ground, Maryland on 4-5 May 1989. ...
... Accession Number : ADA283970. Title : Nitrogen Dioxide-Induced Acute Lung Injury in Sheep. Descriptive Note : Final rept. ...
Intestinal ischemia-reperfusion (I/R) injury may cause acute systemic and lung inflammation. Here, we revisited the role of TNF-alpha in an intestinal I/R model in mice, showing that this cytokine is not required for the local and remote inflammatory response upon intestinal I/R injury using neutralizing TNF-alpha antibodies and TNF ligand-deficient mice. ...
Despite the associated morbidity and mortality, underlying mechanisms leading to the development of acute lung injury (ALI) remain incompletely understood. Frequently, ALI develops in the hospital, coinciding with institution of various therapies, including the use of supplemental oxygen. Although pathological evidence of hyperoxia-induced ALI in humans ...
BackgroundInjurious non-microbial factors released from the stressed gut during shocked states contribute to the development of acute lung injury (ALI) and multiple organ dysfunction syndrome (MODS). Since Toll-like receptors (TLR) act as sensors of tissue injury as well as microbial invasion and TLR4 signaling occurs in both sepsis and noninfectious ...
Congenital Heart Disease; Cardiopulmonary Bypass; Myocardial Injury; Acute Kidney Injury; Acute Lung Injury
ClinicalTrials.gov
Activated platelets have been implicated in playing a major role in transfusion-related acute lung injury (TRALI), as platelets can trigger neutrophils, resulting in vascular damage. We hypothesized that binding of platelet CD40 ligand (CD40L) to endothelial CD40 is essential in the onset of TRALI. Mice were challenged with monoclonal major ...
... Abstract : Delayed treatment with ibuprofen in this porcine model of acute lung injury confers significant protection from the lung injury induced by ...
Among the multiple organ disorders caused by the severe acute respiratory syndrome coronavirus (SARS-CoV), acute lung failure following atypical pneumonia is the most serious and often fatal event. We hypothesized that two of the hydrophilic structural coronoviral proteins (S and E) would regulate alveolar fluid clearance by decreasing ...
Granzyme K (GrK) is a trypsin-like serine protease that is elevated in patients with sepsis and acute lung inflammation. While GrK was originally believed to function exclusively as a pro-apoptotic protease, recent studies now suggest that GrK may possess other non-cytotoxic functions. In the context of acute lung ...
Acute lung injury carries a high burden of morbidity and mortality and is characterised by nonhydrostatic pulmonary oedema. The aim of this paper is to highlight the role of accurate quantification of extravascular lung water in diagnosis, management, and prognosis in "acute lung injury" and ...
Acute lung injury carries a high burden of morbidity and mortality and is characterised by nonhydrostatic pulmonary oedema. The aim of this paper is to highlight the role of accurate quantification of extravascular lung water in diagnosis, management, and prognosis in �acute lung injury� ...
Margination and activation of monocytes within the pulmonary microcirculation contributes substantially to the development of acute lung injury in mice. The enhanced LPS-induced TNF expression exhibited by Gr-1(high) compared to Gr-1(low) monocytes within the lung microvasculature suggests differential roles for these subsets. We ...
Acute Lung Injury; Acute Respiratory Distress Syndrome; Severe Sepsis; Septic Shock; Mechanical Ventilation
