In this proposal, we focus on, and have preliminary data to support, a novel approach targeting metabolism (by inhibition of glycolysis) to compliment ongoing clinical efforts to abrogate growth factor and apoptotic pathways in prostate cancer. The propos...

... Targeting of individual genes may not be sufficient to completely abrogate RRM-mediated cell death. ... TELEPHONE NUMBER (include area code) ...

In this proposal, we focus on, and have preliminary data to support, a novel approach targeting metabolism (by inhibition of glycolysis) to compliment ongoing clinical efforts to abrogate growth factor and apoptotic pathways in prostate cancer. The propos...

KLF6 is a zinc finger transcription factor mutated in more than 50% of sporadic prostate cancers. Our studies have explored the role of acetylation of KLF6 and how its abrogation by mutation in human cancer may contribute to its dysregulation and emergenc...

Prostate Cancer; Adenocarcinoma of the Prostate; Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer

Adenocarcinoma of the Prostate; Stage I Prostate Cancer; Stage II Prostate Cancer; Stage III Prostate Cancer; Stage IV Prostate Cancer