... Inhibition of these properties which are associated with macrophage-related immunosuppression could explain the immunoenhancement induced ...

... treatment with G2-phase checkpoint abrogators may sensitize cancer cells ... development of drugs that abrogate the G2-phase checkpoint for potential ... ...

... ELECTRODES, *PIEZOELECTRIC CRYSTALS, *QUARTZ RESONATORS, *FLAT PLATE MODELS, *CRYSTAL OSCILLATORS, REPRINTS ...

... ADP001513. Title : Thermal Frequency Behavior in Contoured Quartz Crystal Plates Induced by Direct Irradiation of Laser Beam,. ...

We present preliminary results of a study on the variation of combinations of PDF orientations in quartz grains. PDF orientations within the studied samples reflect the symmetry of ?-quartz, but it appears as if some quartz grains were of ?-quartz type when the PDFs formed.

... activity on the binding of anti-CXCR4 antibody was evaluated as well as their ability to abrogate the migratory response of cells induced by SDF-I_. ...

Our atomistic computer simulations mainly based on classical force fields suggest that the pressure-induced transition from ? quartz to quartz II at 21GPa is irreversible. While quartz II is ferroelastic in principle, the transition itself is coelastic, as the shape of the newly formed crystal is determined by ...

Earlier studies of transient frequency changes in high-purity swept AT quartz resonators led to the conclusion that impurity-induced effects were small, while the observed changes were qualitatively and quantitatively well characterized in terms of the ti...

... QUARTZ, BRITTLENESS, DISLOCATIONS, ALUMINUM OXIDES, INTERNAL, DUCTILITY, ZIRCONIUM OXIDES, MAGNESIUM OXIDES. ...

Abstract submitted for 82nd annual meeting of the American Association for Thoracic Surgery, May 4-8, 2002 in Washington D.C. Targeted Deletion of Inducible Heat Shock Protein 70 Abrogates the Late Infarct-Sparing Effect of Myocardial Ischemic Preconditioning Craig...

Cells of Saccharomyces cerevisiae and their metabolites were successfully utilized to achieve selective separation of quartz and calcite through microbially induced flotation and flocculation. S. cerevisiae was adapted to calcite and quartz minerals. Adsorption studies and electrokinetic investigations were carried out to understand ...

The effect of ionizing radiation on the internal friction of 5 Mc shear waves in AT-cut synthetic quartz resonators was measured over a temperature range of 10 to 400 deg K as a function of the rate of growth of the parent quartz crystal. It is found that in all specimens the 50 deg K peak is removed by irradiation and that for slowly grown ...

The luminescence intensity induced by x radiation in quartz dust is dependent on the (previous treatment of the quartz. Singly activated quartz maintains its activity after x irradiation for a long time. The luminescence intensity maximum is atfected by the length of the irradiation. The luminescence ...

... INTRODUCTION Although glial progenitor cells are radiosensitive, recent studies have suggested that radiation-induced apoptosis of the endothelial cells initiates a cascade of events resulting in injury to...

... Accession Number : ADA095673. Title : Temperature Induced Frequency Changes in Electroded AT-Cut Quartz Trapped Energy Resonators,. ...

... a mode-locked Nd-YAG oscillator-amplifier-frequency ... KDP, quartz, sapphire and calcium fluoride. ... previous work on laser induced breakdown and ...

The effect of coal-quartz mixtures that contained graded amounts of coal or quartz was studied using peritoneal macrophage cultures and plasma-free washed sheep erythrocyte suspensions. A stoichiometric relationship was observed between the quartz content of coal-quartz mixture and the amount of lactic ...

Two-dimensional visualization of a liquid fuel film on a quartz cylinder liner was performed in a spark ignition engine rig. The visualization method was based on laser-induced fluorescence and total reflection. Using a quartz cylinder liner and a special quartz prism, only the liquid fuel on the cylinder liner was ...

Guinea pig peritoneal macrophages were incubated in vitro with various concentrations of selenium (as sodium selenite), quartz, and quartz + selenite. Cellular viability, adhesiveness, migration, and lipid peroxide content as parameters for cytotoxicity were studied. A dose-dependent cytotoxic response of macrophages to selenite was observed. Selenite ...

The oscillation frequency behavior of the quartz crystal plates is observed, while a laser beam as a kind of probe is irradiating different points of their principal surfaces. Such frequency behavior is characteristic to the respective angle of cut and is...

While high temperature electrolysis has proven beneficial as a technique to remove interstitial impurities from quartz, reliable indices to measure the efficacy of such a processing step are still under development. The present work is directed toward pro...

For the BABAR experiment, an amplitude and timing analysis of photons produced by a proton beam in a quartz bar has been performed. The photoelectron yield is obtained for different angles and positions. It is found that the linear speed of propagation of...

The purpose of this study was to determine the type and extent of pulmonary fibrosis experimentally induced in hamsters by intratracheal instillations of quartz, fibrous glass, hydrated alumina, or a 1:1 mixture of quartz and ferric oxide. The objective w...

Nuclear magnetic resonance (NMR) analysis of the recovered products from a series of controlled explosive shock-loading experiments on quartz powders was performed to investigate shock-induced amorphization processes. Silicon-29 NMR spectroscopy is an exc...

When irradiation dose by protons is high enough, all chemical and physical processes of space weathering of anorthite and quartz particles in lunar regolith will occur in the radiation-induced amorphous film, without reaching crystal lattice.

IR spectroscopy has been used to study the effect of reactor radiation on the structural state of different specimens of synthetic quartz crystals. The patterns have been established for modification of the spectral characteristics of the bending vibrations of the crystal lattice as a function of the orientation of the crystals and the fast neutron fluence. It is hypothesized ...

of the coloration did not change during sample prepara- tion and heating. The quartz samples were then dissolved of color As noted earlier, the heating experiments by Ignatov et al. (1990) showed that their rose quartz minerals, color loss on heating is associated with radiation-induced colors. Because rose quartz ...

... induced stimulation of c-Fos activity is abrogated by ElA. ... apoptosis in human MDA-MB-435 breast cancer cells. ... Opinion Cell Biol., 9: 240-246, 1997 ...

... endothelial cells (EC), a critical target cell for radiation injury (8�10). Radiation induces endothelial activation, reflecting a ... exposure may effectively abrogate the progression of delayed radiatio...

... Loss of p16/Rb signaling unveils stress-induced ... that p16-mediated regulation of cell cycle is abrogated. ... Rb signaling may cause cells to become ...

Photophysical properties of Rhodamine B bound to water-soluble polyanion sodium poly(4-styrenesulfonate) (PSS) in solution and Quartz/APES/PSS/RB SAMs were investigated. Experiments showed that Rhodamine B aggregated in Quartz/APES/PSS/RB SAMs and its fluorescence behavior was different from that in Quartz/APES/RB SAMs without PSS. The ...

... during electrochemically induced adsorption/desorption processes of surfactants ... aqueous solution of NaCIO4 ... the insertion of the anionic species ...

... on metals, inorganic crystals and glasses, adhesive failure ... eg, filled with small glass beads), we ... quartz window and a bialkali photosensitive surface ...

... 28. Random-vibration-induced phase-noise degradation. 31 ... According to this glossary, aging is "the systematic ... with time due to internal changes in ...

... of damage to quartz and pyrolytic carbon on Nimonic 90 alloy and H46 steel at room ... and sea-salt induced crevice corrosion and sulfidation ...

... quartz crystal thickness monitor was used to measure ... to obtain monolayers with good optical quality and ... A Raman enhancement factor of 3x10 6 ...

The purpose of the work is to investigate methods leading to the design of quartz crystal units that are stable with respect to mechanically induced vibration and acceleration. Numerous experimental and theoretical aspects of the reactions of a vibrating ...

This invention related generally to improvements in the acceleration sensitivity of quartz crystal oscillators and more particularly to the elimination of acceleration-induced frequency shifts in such oscillators. A crystal oscillator, including two cryst...

ABSTRACT: In this paper, a new friction-induced nanofabrication method is presented to fabricate protrusive nanostructures on quartz surfaces through scratching a diamond tip under given normal loads. The nanostructures, such as nanodots, nanolines, surface mesas and nanowords, can be produced on the target surface by programming the tip traces according ...

In this paper, a new friction-induced nanofabrication method is presented to fabricate protrusive nanostructures on quartz surfaces through scratching a diamond tip under given normal loads. The nanostructures, such as nanodots, nanolines, surface mesas and nanowords, can be produced on the target surface by programming the tip traces according to the ...

BackgroundParticles are known to induce both cytokine release (MIP-2, TNF-?), a reduction in cell viability and an increased apoptosis in alveolar macrophages. To examine whether these responses are triggered by the same particle determinants, alveolar macrophages were exposed in vitro to mineral particles of different physical-chemical properties.ResultsThe crystalline ...

Modification of the quartz surface by aluminium salts and metallic iron have been shown to reduce the biological activity of quartz. This study aimed to investigate the ability of water soluble extracts of coal mine dust (CMD), low aluminium clays (hectorite and montmorillonite) and high aluminium clays (attapulgite and kaolin) to inhibit the reactivity of ...

Quartz pebbles from the Roter Kamm impact crater (the Namib Desert, SWA/Namibia) were examined for evidence of impact-induced hydrothermal activity, using results from microprobe analyses, neutron activation analyses, transmission IR spectroscopy, and X-ray diffractometry. It was found that the pebbles consisted of pure quartz, which ...

We studied the capacity of quartz and asbestos fibers to induce the generation of reactive oxygen metabolites in human polymorphonuclear leukocytes (PMNs) with a chemiluminescence (CL) assay. On an equal weight basis, the particulates induced CL in the following order of magnitude: chrysotile, quartz > amosite, ...

It is shown that a quartz crystal, which is placed inside a telescope and whose optic axis is parallel to a light beam, can reduce the depolarisation of radiation caused by thermally induced birefringence in a Faraday isolator. The isolation ratio was experimentally increased by a factor of eight. An important advantage of this method over previous methods ...

A EUVL reticle blank was fabricated on a specially polished quartz blank. The stress-induced distortion of the multilayer coating was unacceptably large. The distortion can be effectively eliminated by coating the backside of the reticle blank with an identical coating. This strategy has the potential to eliminate multilayer induced ...

Cantilever beam measurements of the stress induced in crystalline quartz by implantation of 150 keV and/or 250 keV He have shown that the data scale with energy into collisional processes. The damage state induced by the Ar implants does not lend itself t...

Various physical and chemical processes which are involved in laser-induced backside wet etching are investigated. The surface of quartz etched by the laser-induced backside wet etching using a XeCl excimer laser at various fluences is analyzed by Raman microscopy, X-ray photoelectron spectroscopy and fiber-tip attenuated ...

Fracturing quartz produces silica-based radicals on the fracture planes and generates hydroxyl radicals (.OH) in aqueous media. .OH production has been shown to be directly associated with quartz-induced cell damage and phagocyte activation in vitro. This .OH production in vitro is inhibited by desferrioxamine mesylate, an Fe chelator, indicating ...

Radiation induced frequency and resistance changes in precision 5 MHz AT-cut quartz resonators fabricated from electrolyzed, high purity quarts are described. A description is given of the radiation measurement methods, transient and steady-state data, and the results of thermal modeling. It is concluded that SARP optical and Premium-Q ...

An electrode-separated piezoelectric quartz crystal (electrode-separated PQC) is constructed with no electrode attached to either side of the quartz plate, but electrodes are separately inserted in the electrolyte solution on both sides of the quartz plate, and are connected to an oscillator. The frequency shifts due to the solution ...

The mechanisms of apoptosis induced by diallyl disulfide (DADS) were explored in human cervical cancer Ca Ski cells. Flow cytometric analysis, DNA gel electrophoresis and DAPI staining demonstrated that DADS induced apoptosis in Ca Ski cells. DADS induced apoptosis through the production of reactive oxygen species and Ca2+, and ...

, and returned to the incubator. In some experiments, cells were incubated in medium containing 5 mM caffeine a normal S-phase and after acquisition of DNA lesions. Effect of Caffeine on Formation of pol Foci demonstrated previously that the BPDE-induced S-phase checkpoint is abrogated by caffeine treatment (32

Spatial and spectral studies of shock-induced luminescence from both fused and crystalline quartz as a function of stress level revealed the following information: crystalline x-cut quartz has a threshold for emission near the dynamic yield point (about 6 GPa). Fused quartz has a threshold near 16 GPa which is not ...

Earlier studies of transient frequency changes in high-purity swept AT quartz resonators led to the conclusion that impurity-induced effects were small, while the observed changes were qualitatively and quantitatively well characterized in terms of the time changing temperature of the vibrating quartz and its effect on frequency. 5 ...

The conformation of polymers at interface profoundly influences the interfacial properties. Quartz crystal microbalance with dissipation (QCM-D) is a newly developed technique to detect polymer behavior at interface in real time. In this article, we mainly review our QCM-D studies. Our focus is on temperature induced collapse and swelling of tethered ...

Elastic recoil spectrometry induced by 3 MeV helium-4 microbeam has been used to determine hydrogen distribution within melt inclusions trapped in quartz. These minerals were selected from different geological environments: Guadeloupe (West Indies), Pante...

Ion currents induced by high power laser irradiation of transparent dielectric materials in vacuo below the threshold for physical damage have been investigated. Soft glass, Pyrex, fused quartz, Supracil quartz, CaF2, LiF, and sapphire all show similar be...

Suramin, a synthetic polysulfonated anionic compound, is known to abrogate the activity of a variety of growth factors that serve as ligands for receptor-class protein-tyrosine kinases. Based on this information, we initially hypothesized that suramin treatment would be associated with decreased tyrosine phosphorylation. Upon testing this hypothesis in prostate cancer cell ...

Extensional-mode quartz resonators are being increasingly used as force sensors in dynamic scanning force microscopy or atomic force microscopy (AFM). We propose a voltage preamplifier in order to amplify the charge induced on quartz electrodes. The proposed solution has some advantages over the typically used current-to-voltage ...

Extensional-mode quartz resonators are being increasingly used as force sensors in dynamic scanning force microscopy or atomic force microscopy (AFM). We propose a voltage preamplifier in order to amplify the charge induced on quartz electrodes. The proposed solution has some advantages over the typically used current-to-voltage ...

The nanostructure of synthetic quartz samples irradiated with fast reactor neutrons with energies E n > 0.1 MeV has been studied by small-angle neutron scattering. The fluences are varied from 1017 to 2 � 1020 neutrons/cm2. In the quartz samples irradiated with fluences higher than 1017 neutrons/cm2, point, extended (dislocation loops), and volume ...

Fluid inclusions in quartz are known to modify their shapes and microstructures (textures) during weak plastic deformation. However, such changes have not been experimentally demonstrated and criteria are not available to relate them to paleostress conditions. To address these issues, quartz crystals containing natural CO2-H2O-NaCl fluid inclusions have ...

Bovine (BAM) and rat (RAM) alveolar macrophages were incubated in vitro with DQ12 quartz or UICC chrysotile asbestos either alone or in the presence of dipalmitoyl lecithin (DPL). The reaction of the cells of both species to the untreated dust particles was similar qualitatively and quantitatively, with a loss of viability and release of lactate dehydrogenase and ...

Analytical expressions have been developed in which the elastic behaviour of the ?-quartz and ?-cristobalite molecular tetrahedral frameworks of both silica and germania are modelled by rotation, or dilation or concurrent rotation and dilation of the tetrahedra. Rotation and dilation of the tetrahedra both produce negative Poisson's ratios (auxetic behaviour), whereas both ...

Analytical expressions have been developed in which the elastic behaviour of the ?-quartz and ?-cristobalite molecular tetrahedral frameworks of both silica and germania are modelled by rotation, or dilation or concurrent rotation and dilation of the tetrahedra. Rotation and dilation of the tetrahedra both produce negative Poisson's ratios (auxetic behaviour), whereas both ...

The mechanism of enhancement/inhibition of quartz toxicity induced by iron is still unclear. Here the amount of iron on a fibrogenic quartz (Qz) was increased by wet impregnation (Fe(NO(3))(3) 0.67 and 6.7 wt %). X-ray diffraction (XRD), XRF diffuse reflectance, UV-vis, and infrared (IR) spectroscopies revealed dispersed ferric ions, ...

A prototype of the Gravity Probe B quartz block against a black background. The quartz block aligns the four fused-quartz gyroscopes. ...

Polyvinylpyridine-N-oxide (PVPNO) and carboxymethyl cellulose (CMC) are known to inhibit the cytotoxic effects of quartz particles and chrysotile asbestos fibers, respectively. The effect of PVPNO and CMC on mineral dust-induced production of reactive oxygen species (ROS) by human monocyte-derived macrophages was studied using lucigenin-dependent ...

... Descriptors : *QUARTZ, *QUARTZ RESONATORS, AGING (PHYSIOLOGY), BONDING, CONTROL, CRYSTAL OVENS, CRYSTALS, FREQUENCY ...

Chronic inhalation of high concentrations of respirable quartz particles has been implicated in various lung diseases including lung fibrosis and cancer. Generation of reactive oxygen species (ROS) and oxidative stress is considered a major mechanism of quartz toxicity. Curcumin, a yellow pigment from Curcuma longa, has been considered as nutraceutical ...

Mammalian cells undergo cell cycle arrest in response to DNA damage due to the existence of multiple checkpoint response mechanisms. One such checkpoint pathway operating at the G(1) phase is frequently lost in cancer cells due to mutation of the p53 tumor suppressor gene. However, cancer cells often arrest at the G(2) phase upon DNA damage, due to activation of another checkpoint pathway that ...

The present study was undertaken to determine whether subacute treatment with resveratrol (RVT) protects mice against lipopolysaccharide (LPS)-induced oxidative stress and mortality as well as the mechanism involved in such protection. Mice were divided into three groups: control, LPS and LPS+RVT. Animals were pre-treated with RVT during 7 days. The survival rate was monitored ...

... of Apoptosis and Drug Resistance of Human Breast Cancer Cells to Taxane Treatments Using Quartz Crystal Microbalance Biosensor Technology. ASSAY and Drug Development Technologies 3:1, 77-88Online publicati...

The pulsed laser-induced photoacoustic spectroscopy for the speciation of very low concentrations of actinoides in near neutral aquatic solutions is described. Special photoacoustic cells made of two identical piezoelectrical crystals coupled with quartz ...

Techniques are described for the measurement and analysis of ground-borne structural vibration and air-borne low frequency noise in buildings caused by road traffic. A measurement system comprising piezoelectric quartz crystal accelerometers and condenser...

A rapid and sensitive fiber optic biosensor assay for radiation-induced DNA damage is reported. For this assay, a biotin-labeled capture oligonucleotide (38 mer) was immobilized to an avidin-coated quartz fiber. Hybridization of a dye-labeled complementary sequence was observed...

Annealing of individual bands of electron-beam-induced absorption (IA) in the region of 150 � 400 nm in KS-4V, KU-1, and Corning 7980 (ArF Grade) quartz glasses by ArF laser radiation is studied. It is shown that the phototransformation of the IA spectra occurs mainly due to a significant decrease in the amplitudes of bands at ? = 183.5, 213, and 260 nm. ...

Emission intensities of Si and He in a microwave-induced plasma were measured as functions of axial position, He flow rate, and microwave power. The changes in these intensities which accompany plasma-wall contact are described. The conditions required for the plasma to contact the wall of the quartz capillary tube were established, and the vaporization of ...

Endotoxin (lipopolysaccharide, LPS)-induced tumor necrosis factor-? (TNF-?) release from Kupffer cells is critically involved in the pathogenesis of alcohol-induced liver injury. We recently reported that inhibition of alcohol-induced plasma endotoxin elevation contributes to the protective action of zinc against alcoholic ...

show that stimulated MCSP recruits tyrosine-phosphorylated p130cas , an adaptor protein important Cdc42, a Cdc42-associated tyrosine kinase (Ack-1) and tyrosine phosphorylation of p130cas . Furthermore, vectors inhibiting Ack-1 or Cdc42 expression and/or function abrogate MCSP-induced tyrosine

that are deficient in the production of leptin (ob/ob mice) or lack functional leptin receptors (db/db mice) due to genetic defects dis- play excessive obesity but impaired cell-mediated immu- nity [15]. Leptin appears-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486. Brain Behav Immu- nol

Recent advances in cell cycle regulation have led to a suggestion of therapeutically targeting cell cycle checkpoint pathways in cancer cells to increase the toxicity of DNA-damaging agents. In this study, we investigate whether knockdowns of checkpoint kinases Chk1 and Chk2 by RNA interfering potentiate the cytotoxicity and abrogate G(2)/M checkpoint ...

A hypothesis is presented which states that persons with the genetic disorders xeroderma pigmentosum and ataxia-telangiectasia, manifested by a deficiency of DNA repair, develop cutaneous tumors due to the elimination of reticuloendothelial system cells (Langerhans cells) in the skin, and the subsequent loss of control of epidermal cellular elements. 84 references.

In this study, we showed that curcumin treatment resulted in activation of Chk1-mediated G2 checkpoint, which was associated with the induction of G2/M arrest and the resistance of cancer cells to curcumin-induced apoptosis. Further investigation revealed that inhibition of Chk1 significantly abrogated G2/M arrest and sensitized curcumin-resistant cells to ...

To identify key connections between DNA-damage repair and checkpoint pathways, we performed RNA interference screens for regulators of the ionizing radiation-induced G2 checkpoint, and we identified the breast cancer gene BRCA2. The checkpoint was also abrogated following depletion of PALB2, an interaction partner of BRCA2. BRCA2 and PALB2 depletion led to ...

Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF)-?1 is well known as the crucial fibrogenic cytokine promoting ECM production and tissue fibrosis in keloid forming. Epigenetic modifications have been shown to play a role in the pathogenesis of ...

Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G(2) DNA damage checkpoint. The CHK1 inhibitor 7-hydroxystaurosporine (UCN-01) can bypass the checkpoint and induce unscheduled mitosis in irradiated cells. Precisely, how cells behave following checkpoint abrogation remains to be defined. In this study, we tracked ...

Ser(10) was the major phosphorylation site in p27(Kip1) (here after referred to as p27), accounting for 70% of the total phosphorylation of this protein, due to cytoplasmic shuttling. To further elucidate the mechanism for Ser(10)-mediated dysfunction of p27 during breast cancer progression. Affymetrix Human Genome U133A Array was used to identify differentially regulated genes between MCF-7 ...

Cross-sectional and high-resolution transmission electron microscopy (XTEM and HRTEM, respectively) have been used to characterize ion-beam-induced amorphization of {alpha}-quartz irradiated with 1.5 MeV Kr{sup +} ions at room temperature. The accumulation of damage and the growth of the amorphous layers in quartz were studied as a ...

Cross-sectional and high-resolution transmission electron microscopy (XTEM and HRTEM, respectively) have been used to characterize ion-beam-induced amorphization of ?-quartz irradiated with 1.5 MeV Kr+ ions at room temperature. The accumulation of damage and the growth of the amorphous layers in quartz were studied as a function of ion ...

The thermal stabilities and decay kinetics of three peroxy radicals (Centers #1, B and B') and three other radiation-induced defects (#3, C' and E1') in natural quartz from the high-grade McArthur River uranium deposit (Athabasca basin, Canada) have been investigated by isochronal and isothermal annealing experiments and electron paramagnetic resonance ...

... Title : Should the United States Abrogate Sovereignty Rights in the Panama Canal Zone. Descriptive Note : Student essay,. ...

... Title : Immune Dysfunctions and Abrogation of the Inflammatory Response by ... studies with UDMH in the mixed lymphocyte reaction (MLR) assay ...

The effects of samples of crystalline quartz, diatomaceous earth, mordenite and clinoptilolite were investigated in vitro (as concerns erythrocyte haemolysis and lactate dehydrogenase (LDH) release from peritoneal macrophages) and in vivo (on LDH, protein and phospholipids in rat bronchoalveolar lavage (BAL), and phospholipids in rat lung tissue). The respirable mineral ...

High- and low-H samples of natural crystalline quartz in three different conditions (unswept, Na swept, and H swept) were examined and analyzed for their low-temperature near-infrared spectra. The observed lines were attributed to five defect types: Al-OH(-), alkali-affected OH(-) (i.e., Li-H and Na-H); H-sweeping induced; and others. For both high- and ...

Geniposide (GP) as an agonist of glucagon-like peptide-1 receptor (GLP-1R) is an iridoid glycoside from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of vitiligo vulgaris. Interaction of c-kit receptor with its ligand-SCF potent enhances the melanocytic melanogenesis, which can be repressed by norepinephrine (NE). To discover economic and efficient ...

Measurements of induced conductivity were made on samples of boron nitride, quartz, mica compositions, polystyrene, and glass which were electron irradiated at 10/sup 4/ rads/hr. Natural mica and Corning 1723 borosilicate glass exhibited the lowest induced conductivities of the materials tested. (C.J.G.)

Cataclasite, quartz veins, and veins filled with friction melt (pseudotachylyte) are commonly described examples of dilatancy related to coseismic rupture down to depths of 15-20 km, corresponding with the frictional-to-viscous transition (FVT). Less commonly described are microstructural features indicative of coseismic dilatancy, for example highly fractured garnet and ...

Certain forms of hexavalent chromium [Cr(VI)] are human carcinogens. Our recent work has shown that a broad range protein tyrosine phosphatase (PTP) inhibitor, sodium orthovanadate (SOV), abrogated both Cr(VI)-induced growth arrest and clonogenic lethality. Notably, SOV enhanced Cr(VI) mutation frequency, ostensibly through forced survival of genetically ...

The initial stages of T cell activation involve tyrosine protein kinase-mediated intracellular signaling events. Integrin-mediated adhesion of CD4+ T lymphocytes to extracellular matrix glycoproteins, such as fibronectin, is an activation-dependent process. The involvement of tyrosine protein kinases in the adhesion of CD4+ T cells to fibronectin was examined using pervanadate, a protein-tyrosine ...

Arsenicosis, caused by arsenic contamination of drinking water supplies, is a major public health problem in India and Bangladesh. Chronic liver disease, often with portal hypertension occurs in chronic arsenicosis, contributes to the morbidity and mortality. The early cellular events that initiate liver cell injury due to arsenicosis have not been studied. Our aim was to identify the possible ...

A causal pathway between quartz, silicosis and lung cancer has been postulated. The aim of our study was to assess cytotoxic effects induced in a human lung epithelial cell line (A549) by exposure to alpha-quartz. Cells were exposed to respirable alpha-quartz (SRM1878a, NIST) at 25, 50 or 100 microg ml(-1 )for 24 h ...

The aim of the present study was to evaluate the genotoxic effects induced by native and active bentonite particles (BPs) on human B lymphoblast cells using comet assay and cytokinesis-block micronucleus (CBMN) assay in vitro. The cells were exposed to BPs at the concentrations of 30, 60, 120 and 240?g/ml for 24, 48 and 72h, respectively. The quartz ...

The temperature dependence of the amorphization in ?-quartz by Ne-ion bombardment has been investigated using Rutherford Backscattering Spectrometry in channeling geometry (RBS-C). The experimental results show that the critical temperature Tc for inhibiting amorphization in quartz is around 940K. The damage depth profile ?(z,?) is independent of the ...

Certain imperfections in alpha quartz are found to introduce anelastic absorption at low temperatures in crystal resonators. For a shear wave of 5 mc, absorption peaks are observed at approximately 20 and 50 deg K in unirradiated samples. X irradiation effects a lowering of the amplitude of the 50 deg K absorption, while a new absorption is introduced at 100 deg K. ...

The fabrication of acoustic sensors with sol-gel selective coatings requires the deposition of thin films on quartz resonators using solution chemistry techniques. Oxide films are spin-cast, then heat treated. A variety of film compositions are deposited, requiring a variety of firing schedules. Network analysis of the untreated AT-cut quartz devices ...

The dependence of the intensity of the induced absorption bands in fused quartz and sodium silicate glasses on the gamma dose is studied, as well as the influence of cerium, anti mony, arsenic, manganese, iron, and lead additives on the properties of the absorption bands of sodium silicate glasses. The uniformity of the color centers produced in ...

The electronic structure of {alpha}-quartz is investigated within the local-density formalism using recently developed {ital soft} pseudopotentials. We present results for the band structure, density of states, and charge density of {alpha}-quartz at ambient pressure and near the crystalline-to-amorphous transition. The results at ambient pressure compare ...

Planar deformation features (PDFs) in quartz, one of the most commonly used diagnostic indicators of shock metamorphism, are planes of amorphous material that follow crystallographic orientations, and can thus be distinguished from non-shock-induced fractures in quartz. The process of indexing data for PDFs from universal-stage ...

Abstract- Planar deformation features (PDFs) in quartz, one of the most commonly used diagnostic indicators of shock metamorphism, are planes of amorphous material that follow crystallographic orientations, and can thus be distinguished from non-shock-induced fractures in quartz. The process of indexing data for PDFs from ...

Exposure to crystalline silica can result in damage to the lung parenchyma and scarring that can lead to fibrosis. Pulmonary damage may be the direct consequence of toxic interaction between quartz particles and cell membranes, or it may be due to silica-induced production of oxidant species by pulmonary phagocytes, that in turn overwhelms pulmonary ...

Lysophosphatidic acid (LPA) stimulates growth and invasion of ovarian cancer cells and tumor angiogenesis. Cancer-derived LPA induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) to ?-smooth muscle actin (?-SMA)-positive cancer-associated fibroblasts. Presently, we explored whether cancer-derived LPA regulates secretion of pro-angiogenic ...

The abilities of Min U Sil quartz or tridymite particles to induce sister chromatid exchanges (SCEs) in cultures of human lymphocytes plus monocytes or of human purified lymphocytes were investigated. With cultures of lymphocytes plus monocytes the level of SCEs was significantly enhanced after treatment with tridymite at the highest dose tested (50 ...

The optical absorption of gamma - and fast-neutron-irradiated crystalline quartz and fused silica was measured from 186 m mu to 2.6 mu . Dichroism of the A-band was confirmed. The phenomenon of radiation bleaching of the B/sub 1/-band and a remarkable movement of the C-band were found. The irradiation and optical bleaching experiments showed that only the C-band ...

An analysis is made of the influence of the electron flux on the attenuation of a quartz-quartz optical fiber having a core diameter of 40 microns and a cladding diameter of 130 microns. The initial attenuation of the fiber at the 0.82-micron wavelength was 20 dB/km. Pulsed radiation from an electron beam having a flux density of (4.5-29)x10 to the 9th electrons per sq cm per ...

The behaviour of high-purity fluorite and KU-1, KS-4V and Corning 7980 quartz glasses exposed to an electron beam and KrF laser radiation is studied. Exposing these materials to {approx}5-MW cm{sup -2} KrF-laser radiation both during the action of the electron beam and after it reduces their residual absorption at least by a factor of 1.5. (selected papers reported at the ...

We demonstrate the detection of nitric oxide in both air and nitrogen atmospheres with a 5.2 ?m distributed-feedback quantum cascade laser in a quartz-enhanced photoacoustic spectroscopy system. The photoacoustic signal generated by nitric oxide is shown to be several times larger in air than in nitrogen due to the faster vibrational-translational energy relaxation process ...

The ability of magnetic fields (MFs) to promote/increase Ca(2+) influx into cells is widely recognized, but the underlying mechanisms remain obscure. Here we analyze how static MFs of 6 mT modulates thapsigargin-induced Ca(2+) movements in non-excitable U937 monocytes, and how this relates to the anti-apoptotic effect of MFs. Magnetic fields do not affect ...

Inhalation of some respirable crystalline silica (MMAD < approx. 4 ?m) leads to inflammatory and malignant diseases. Comprehensive physicochemical/biological data and suitable in vitro/in vivo methods may distinguish between more or less harmful quartz-varieties. Within the European Collective Research Project SILICERAM an in vitro screening battery was established to ...

Abstract Rationale: Histone deacetylase (HDAC) inhibitors may offer novel approaches in asthma treatment. In this study, we postulate that trichostatin A (TSA), a class 1 and 2 HDAC inhibitor , inhibits airway hyperresponsiveness in antigen-challenged mice. Methods: Mice were sensitized and challenged with Aspergillus fumigatus antigen (AF) and treated with TSA, dexamethasone, or vehicle. Lung ...

BackgroundDuring a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic microtubule inhibitor, results in strong up-regulation of cyclin B1 and Cdc2 levels, and their increases are ...

Redox and ROS regulation of MAPK-mediated TNF-? biosynthesis is not well characterized. It was hypothesized that the involvement of the MAPK pathway in regulating LPS-mediated TNF-? secretion is redox-dependent, NF-?B-sensitive and attenuated by N-acetyl-L-cysteine (NAC) and other antioxidants.In alveolar epithelial cells, LPS induced a time- and dose-dependent phosphorylation ...

The instigation and persistence of an inflammatory response is widely considered to be critically important in quartz-induced lung cancer and fibrosis. Macrophages have been long recognised as a crucial player in pulmonary inflammation, but evidence for the role of type II epithelial cells is accumulating. Investigations were performed in the rat lung type II cell line RLE and ...

BACKGROUND & AIMS: The mammalian target of rapamycin (mTOR) plays a pivotal role in Hepatocellular Carcinoma (HCC). Previous studies indicated that inhibition of mTORC1 enhanced histone deacetylase inhibitors (HDACis)-mediated anti-tumor activity, accompanied with feedback activation of AKT.Therefore, dual targeting of mTORC1/C2 should be more efficient in suppressing AKT activity and in ...

BackgroundCheckpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.Principal FindingsFragment screening, structure guided design, and kinase cross ...

We report on laser printing of conducting polymers directly from the solid phase. Laser induced forward transfer is employed to deposit P3HT:PCBM films on glass/ITO/PEDOT:PSS substrates. P3HT:PCBM is widely used as the active material in organic solar cells. Polyaniline films, which are also printed by laser induced forward transfer, find many applications ...