... Abstract : The effect on kidneys of X radiation at doses ranging from 500 rad to 4000 rad and measured in unilaterally nephrectomized weanling (24 ...

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The effects on the thymus of 5O r whole-body irradiation and of 50 r to the anterior half of the body, as judged by changes in weight and DNA-content, were indistinguishable. The direct effect of radiation was not altered by adrenalectomy and was recovered in five days. Using the same criteria of effect, ...

In isolated preparations, mucosal acid was secreted with counterpart serosal base independently of electrogenic activity. Irradiation had no effect directly on the electrogenic mechanism between 135 rad and 11 k rad, although abscopal effects showing dose...

... aux-Roses cedex, France bCommissariat � l'Energie Atomique, Direction des Sciences du Vivant, D�partement de Radiobiologie ... Expression in the Lungs Commissariat � l'Energie Atomique, Directio...

Among the lesions brought about by total body irradiation, two basically different types can be distinguished: those appearing in the area which has absorbed radiant energy and those emerging in areas remote from the irradiated tissues (abscopal effects). The abscopal effects are produced by tissue ...

Data are submitted on overall pyridoxal phosphate pyridoxamine phosphate content of subcellular fractions of the cerebral hemisphere, myocardium, and liver of rats in the presence of inhibition and stimulation of M-cholinoreactive structures before and after exposure to total-body radiation in a dosage of 40 R.

The effect on kidneys of X radiation at doses ranging from 500 rad to 4000 rad and measured in unilaterally nephrectomized weanling (24-25 days old) and yound adult (80 days old) rats. Kidney mitotic activity 2-3 days following uninephrectomy was compared...

... signaling from irradiated to non-irradiated cells. Curr. Cancer Drug Targets 4:53�64.2004. CrossRef, PubMedHamada, N., H. Matsumoto, T. Hara, and Y. Kobayashi. Intercellular and intracellular signaling .....

An inflammatory reaction is a classical feature of radiation exposure and appears to be a key event in the development of the acute radiation syndrome. We have investigated the radiation-induced inflammatory response in C57BL6/J mice after total abdominal or total-body irradiation at a dose of 15 Gy. Our goal was to determine the ...

A cytofluorimetric study was made of DNA content of nuclei of mature neutrophil granulocytes in the bone marrow of rats exposed to 1000 and 2000 rad radiation with the hind limbs shielded. It was shown that production of leukocytes with high DNA content (4 and 8 s) in bone marrow is related to the direct and mediated (abscopal) effect ...

The series of parabiont and irradiated rats has been completed, the lesions diagnosed and the data pertinent to tumors computerized and partly analyzed. The same series yielded 74 percent incidence of cataract in the irradiated partner following a whole-body dose of 1000 R with 0.2 percent in the shielded partner and also in controls. There was no abscopal ...

In the guinea pig, the LD/sub 50/30/ varies according to the type of vegetables fed in the diet. Following whole body irradiation to a LD/sub 50/30/, deposition of excess neutral fat occurs in the central zone of the liver lobule at the time of the acute phase of the radiation syndrome. A drop in liver glycogen and an increase in liver water are observed ...

The term radiation-induced bystander effect is used to describe radiation-induced biological changes that manifest in unirradiated cells remaining within an irradiated cell population. Despite their failure to fit into the framework of classical radiobiology, radiation-induced bystander effects ...

Effects of 200 to 600 r of x irradiation on tibial bone growth in groups of weanling male rats were studied by in vivo measurement of tibial bone growth in serial radiographs. By comparison of growth rates in shielded with unshielded legs, direct and indirect effects of radiation were demonstrated, both roughly dose dependent, ...

IntroductionThe abscopal effect is the effect of radiation therapy at a site distant to the area of irradiation. This is not a common event and has not been clearly defined, resulting in few reported cases in the literature. We discuss this phenomenon in a patient with hepatocellular carcinoma.Case presentationA ...

The present study extends our earlier observations on gastrointestinal pathology in thorax-irradiated female CFLP mice. It shows that exposure of the lower mediastinum to single doses of 14 to 30 Gy x rays results in the formation of the proximal duodenal ulcer accompanied frequently by erosion of the antral gastric mucosa. X irradiation of the lateral thoracic fields is responsible for single ...

PurposeThis study tested the hypothesis that the type of dose-fractionation regimen determines the ability of radiotherapy to synergize with anti-CTLA-4 antibody.Experimental designTSA mouse breast carcinoma cells were injected s.c. into syngeneic mice at two separate sites, defined as a �primary� site that was irradiated, and a �secondary� site outside the radiotherapy field. When both ...

Abstract Purpose: To demonstrate the abscopal mutagenic effect of low-energy-ion irradiation in dormant plant seeds, and its dependence on the targeted portion of seeds. Materials and methods: Arabidopsis thaliana-lines transgenic for b-glucuronidase (GUS) recombination substrates and A. thaliana RADiation54 (AtRAD54) promoter::GUS ...

Abscopal responses of hemopoietic tissue, which we noted in preliminary studies of mice receiving partial-body irradiation, led us to clarify these effects. In studies reported here, one hind leg of CF-1 female mice received 1000, 5000, or 10,000 rad of x radiation. We found a persistent shift from medullary to splenic erythropoiesis ...

The composition of the serum proteins of the rat, evaluated 24 hours after irradiation by paper electrophoresis, on the basis of an internal standard of comparison, showed a significant, dose-dependent increase in the alpha /sub 2/ -globulin fraction. The growth-promoting activity of the serum, evaluated 24 hours after irradiation by incorporating the serum in the medium of replicate ...

Post-irradiation treatment with auxin is shown to reverse the depression in levels of RNA and rooting that take place in the petiole base after irradiation of the lamina. Auxin does not reverse the activation of soluble and particulate ribonucleases, but does activate RNA synthesis. These observations are considered to support the concept that the correlative agent is auxin, that the ...

The present study extends our earlier observations on gastrointestinal pathology in thorax-irradiated female CFLP mice. It shows that exposure of the lower mediastinum to single doses of 14-30 Gy X rays results in the formation of the proximal duodenal ulcer accompanied frequently by erosion of the antral gastric mucosa. X irradiation of the lateral thoracic fields is responsible for single ulcers ...

... an image analysis system and stored in the computer. When the image process was completed, the chosen shoot apical meristems were ... ...

Whole body irradiation (WB1) produces scopal and abscopal effects in albino rats. Primary scopal events are deploymerization of interstitial substance (1SW) mucoprotein, with increases in acid, free water and in destruction of mobile cells of 1 SW (erythr...

Exposure of cultured cells and small animals to ionizing radiation as well as irradiation of cultured cells with He-Ne laser can cause changes in the functional condition of plasma membranes. The ionizing radiation-induced cell membrane alterations have been determined after either partial or local exposures. The aim of the present study was to reveal ...

The RNAse content (i.e., total enzymatic activity after removal of inhibitors and disruption of mitochondria) was measured at 4, 28, and 48 hrs after whole-body irradiation with 400 and 1000 r in a number of organs of the rat. No changes were observed in the liver and kidney, and only small changes in the brain. In spleen, the activity of the organ as a whole did not rise, but the ...

Grossly visible cataract developed by 500 days postradiation in 74 percent of the irradiated members of parabiotic pairs of NEDH rats, one of which had received 1000 R whole-body 250 kVp x radiation while the other was shielded to assure survival of the pair. The earliest time at which induced cataract was noted was 106 days postradiation, with the peak rate of occurrence ...

The degree of damage to the thymus caused by direct irradiation with 25 to 100 r was not altered by a fifty-fold change in dose rate. It was not possible to confirm the often-cited finding that the effect of abdominal irradiation on the thymus is due to stimulation of the adrenal gland. Abdominal irradiation of starved adult rats with 2000 or 5000 r caused a 25 to ...

The abscopal effect of irradiation (that which is evident at a distance from the irradiated volume but within the same organism) was investigated in rats. It was possible to demonstrate the effects on growth locally and abscopally when x-ray doses of 400 and 800 r were delivered to the lower extremity and ...

The radiation-induced bystander effect has been demonstrated in whole organisms as well as in multicellular tissues in vitro and single-cell culture systems in vitro. However, the time course of bystander signaling, especially in whole organisms, is not clear. Long-distance bystander/abscopal effects in vivo in ...

Radiation is considered to be one of three or four major hazards for personnel in space and has emerged as the most critical issue to be resolved for long-term missions, both orbital and interplanetary. Space habitats are stressful and dangerous environments. Health and medical consequences arising from microgravity, stress, and trauma include weakened immune systems, ...

Localized irradiation is a common treatment modality for malignancies in the pelvic-abdominal cavity. We report here on the changes in bone mass and strength in mice 7-14 days after abdominal irradiation. Male C57BL/6 mice of 10-12 weeks of age were given a single-dose (0, 5, 10, 15 or 20 Gy) or fractionated (3 Gy � 2 per day � 7.5 days) X ray to the abdomen and monitored daily for up to 14 ...

The instantaneous rate of skeletal growth and metabolism in normal aging and after cxposure to x-irradiation is compared. The radioisotope technique of Bauer was employed to quantify the alterations in the rate of accretion (A) and calcium exchange capacity (E) of various bones of young growing rats after whole- and partial-body x irradiation. In the animals in which one limb was exposed ...

The spine is the most common site for bone metastases. Radiation therapy is a common treatment for palliation of pain and for prevention or treatment of spinal cord compression. Helical tomotherapy (HT), a new image-guided intensity modulated radiotherapy (IMRT), delivers highly conformal dose distributions and provides an impressive ability to spare adjacent organs at risk, ...

In the late 1940s and early 1950s the nuclear workers of the Mayak Production Association in the Southern Urals were exposed to high doses from gamma-rays and from incorporated plutonium. In addition, the population of the Techa riverside downstream of the plutonium-production sites received continued exposures from external gamma-rays due to fission products released into the river and from the ...

Our previous studies demonstrated distant/abscopal bystander effects in A. thaliana seeds and embryos; the postembryonic development of bystander tissues, such as root hair differentiation, primary root elongation, lateral root initiation and survival, were inhibited significantly by localized irradiation with microbeam protons and low-energy ions. In the ...

Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation. This therapy can result in injury to multiple tissues and might result in death as a result of multiorgan failure. The hypothalamic-pituitary-adrenal (HPA) axis could play ...

After one single irradiation the activity of the radiotoxins, as followed by an abscopal effect produced in an ascites tumor, is progressively reduced. Furthermore, by introduction of carbon particles in the bloodstream of parabiotically united rats, it is possible to achieve an partner, after previous irradiation of the other animal. Such ...

Acute duodenal ulcers are produced in mice as a remote (abscopal) effect of irradiation to the lower mediastinum. Such lesions have been examined with scanning electron microscopy at 5, 8 and 28 days after irradiation with 18 Gy of X-rays. All the ulcers occur within the first 1 cm long segment of the duodenum which is endowed with Brunner's ...