BackgroundCytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)₂D3, as well as 1-hydroxyvitamin D3 to 1?,20-dihydroxyvitamin D3 (1,20(OH)₂D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone (7DHP), which can be transformed to 20(OH)7DHP. UVB induces transformation of the ...

Replacing the 1alpha-OH group of the natural hormone 1alpha,25-dihydroxyvitamin D(3) (calcitriol) by a 1alpha-CHF(2) group and incorporating a potentiating side chain produced two new hybrid analogs 6 and 7. Both of these two hybrid analogs are as transcriptionally active as calcitriol and are strongly antiproliferative in vitro but are low-calcemic in ...

The analysis of mice that lack systemically the actions of the active form of vitamin D, 1,25(OH)(2)D, has shown that 1,25(OH)(2)D is an essential regulator of calcium homeostasis and that its actions are aimed at maintaining serum calcium levels within narrow limits. Especially the stimulation of intestinal calcium transport by 1,25(OH)(2)D is important for calcium and bone ...

1,25-Dihydroxyvitamin D (1,25-(OH)2D3) directly suppresses the secretion and synthesis of PTH in vivo and in cell culture. This compound has been used to treat secondary hyperparathyroidism associated with renal failure, but in some patients prolonged treatment with 1,25-(OH)2D3 results in hypercalcemia. An analogue of 1,25-(OH)2D3 with little or no calcemic ...

... phosphate, monopalmitin, palmitic acid, phospholipase D (cabbage), ... acid phosphatase. In this study, phospholipase D activity was absent in ...

Several vitamin D analogues, with reduced hypercalcemic and hyperphosphatemic toxicity at therapeutic dosages, are in clinical use for prevention and treatment of secondary hyperparathyroidism (HPT) in chronic renal failure. We have performed a first in vitro evaluation of five vitamin D analogues displaying less calcemic activity in normal rats, ...

Phosphatidylinositol (Ptdlns) and its metabolites are suspected of having a critical role in cellular signaling by hormonal agents. Parathyroid hormone (PTH) in particular has been shown to alter Ptdlns turnover in kidney preparations. In bone, PTH and other calcemic hormones affect the degree and extent of mineralization. The mechanism of bone resorption by these agents was ...

Vitamin D deficiency appears to be an underestimated risk factor for cardiovascular disease in patients with chronic kidney disease. Evidence from both basic science and clinical studies supports the possible protective role of vitamin D beyond its effect on mineral metabolism. Toxicity of pharmacologic doses of active vitamin D metabolites, in particular calcitriol, is mainly ...

In order to obtain vitamin D derivatives, which have strong activity for enhancing bone growth, we designed vitamin D derivatives with various substitutions at the C-2 position. Novel 2 ?-substituted vitamin D derivatives were synthesized starting from d-glucose as a chiral template of the A-ring with a CD-ring bromoolefin unit using the Trost coupling method. We evaluated ...

Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component. 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D(3)], the biologically active metabolite of vitamin D, has shown efficacy in animal autoimmune disease models of multiple sclerosis, rheumatoid arthritis, ...

Cultured female-derived human bone cells (hObs) responded by different parameters to different phytoestrogenic and vitamin D compounds. Pre- and post-menopausal hObs express ER? and ER? mRNA with higher abundance of ER?. Pre-treatment with the less-calcemic vitamin D analog JKF 1624F(2)-2 (JKF) upregulated responsiveness to estrogens via modulation of ERs expression. These ...

... reflex irritability") Pulls away, sneezes, or coughs with stimulation Facial movement only (grimace) with stimulation Absent (no response to stimulation) Activity (muscle tone) ...

Data on comparison of the biologic action of 1,25(OH)2D3 and 1 alpha OH D3 in normal subjects and uremic patients, intestinal absorption of phosphate in patients with renal failure, skeletal resistance to the calcemic action of parathyroid hormone (PTH) i...

Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin D. 1,25-(OH)(2)D(3), the ligand for the vitamin D receptor ...

Geometric isomers (5E,7E) of major active metabolites of vitamin D3 [1alpha,25(OH)2D3 and (24R)-1,24(OH)2D3] were synthesized by a new convenient procedure. Vitamin D triene system of the metabolites was first derivatized as a Diels-Alder adduct. Removal of the triene protecting group, in a key synthetic step, yielded the title compounds PRI-2208 and PRI-2209, respectively. ...

The active form of vitamin D(3), 1?,25-dihydroxyvitamin D(3)(1?,25(OH)(2)D(3)), has anti-proliferative and anti-invasive activities in prostate cancer cells. Because of 1?,25(OH)(2)D(3) therapeutic potential in treating cancers, numerous analogs have been synthesized with an attempt to increase anti-proliferative and/or decrease ...

The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), and a series of 2-methylene-19-nor analogs of 1,25(OH)(2)D(3) were evaluated for their ability to reduce the size of utricles (comedolytic activity) in a rhino mouse model of acne. All analogs tested, as well as the native hormone, increased the skin epidermal thickness. In ...

The use of hypocalcemic vitamin D analogs is an appealing strategy to exploit the immunomodulatory actions of active vitamin D in vivo while circumventing its calcemic side effects. The functional modulation of dendritic cells by these molecules is regarded as the key mechanism underlying their ability to regulate T cell reactivity. In this article, we ...

The 20-epi-vitamin D3 analogues are a novel class of vitamin D3 derivatives, structurally related to 1 alpha,25-dihydroxycholecalciferol (1 alpha,25(OH)2D3). They are characterized by an altered stereochemistry at carbon 20 in the side-chain. In vitro, these new analogues were found to be considerably more potent as regulators of growth and differentiation in the human histiocytic lymphoma cell ...

Decreased nerve growth factor (NGF) synthesis in the hippocampus and reduced nerve growth factor receptor immunoreactivity in CH1-4 basal forebrain areas have been implicated in neurodegeneration. Vitamin D receptors (VDR) have been located in brain areas affected by neurodegenerative diseases. 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active form of vitamin D, has been ...

The cytotoxic, anti-proliferative and apoptotic effects of 3-Bromoacetoxy Calcidiol (B3CD), a derivative of vitamin D3 precursor calcidiol, on human neuroblastoma (NB) cells were examined. NB, predominantly a tumor of early childhood, is the most common extracranial solid tumor. Despite aggressive treatments, survival for advanced stages remains low and novel treatment strategies are needed. ...

The cytotoxic, anti-proliferative and apoptotic effects of 3-Bromoacetoxy Calcidiol (B3CD), a derivative of vitamin D₃ precursor calcidiol, on human neuroblastoma (NB) cells were examined. NB, predominantly a tumor of early childhood, is the most common extracranial solid tumor. Despite aggressive treatments, survival for advanced stages remains low and novel treatment ...

Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component. 1,25-dihydroxyvitamin D3 [1,25-(OH)₂D₃], the biologically active metabolite of vitamin D, has shown efficacy in animal autoimmune disease models of ...

Sperm nuclear decondensing activity in mammalian oocytes is dependent upon the maturational state of the oocyte. It is maximal in mature, metaphase II oocytes and minimal or absent in immature germinal vesicle (GV) and fertilized pronuclear oocytes. Previ...

Sperm nuclear decondensing activity in mammalian oocytes is dependent upon the maturational state of the oocyte. It is maximal in mature, metaphase II oocytes and minimal or absent in immature germinal vesicle (GV) and fertilized pronuclear oocytes. Previous studies suggested tha...

Two girls and their mother with multicore myopathy are described. The cores consisted of Z band disorganisation and decreased or absent enzyme activity. Only one case has clinical signs of myopathy. Muscle enzyme activity was elevated in the two children. The mode of inheritance was autosomal dominant.Images

BackgroundFollowing the rapid increase of migrant workers in China, the number of "absent migrant parents" children is also rising fast. The "absent migrant parents" children might have an insecure relationship with their parents, have a different view of them, and be prone to have the feeling of loneliness. The purpose of the study was to compare the ...

The thermodynamics of energy conversion through heat-activated heat pumps are described. Some practical systems, heat performances and recent developments in this field are discussed. A distinction is made between processes which depend on the transfer of mechanical energy and systems that are characterized by the fact that moving parts are absent or ...

The physiological function of vitamin D in fishes still remains uncertain. Earlier we observed no relationship between vitamin D3 content of several freshwater fishes and their calcemic/phosphatemic status and bone mineral content. In the present study the effects of vitamin D3 and its metabolites, 25-hydroxy vitamin D3 (25-OH-D3) and 1,25-dihydroxy vitamin D3 [1,25-(OH)2D3], ...

Calcitriol (3?,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-1?,3?,25-triol) is a powerful oncostatic form of vitamin D3 that is of limited clinical utility due to hypercalcemic (toxic) effects. Since the removal of the side chain reduces or eliminates the calcemic activity of vitamin D3, secosteroidal compounds lacking or with a shortened side chain are good ...

The renin-angiotensin system (RAS) plays a central role in the pathogenesis of hypertension. Recently, we discovered that 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] functions as a negative endocrine regulator of renin biosynthesis, which provides a molecular basis to explore the potential of Vitamin D analogs as renin inhibitors to control the RAS. To search for renin-inhibiting Vitamin D ...

Receptor activator of nuclear factor-?B ligand (RANKL) is a TNF-like factor that is both produced by osteoblasts, mesenchymal cells, and activated T cells and required for osteoclast maturation and survival. The gene is up-regulated by the two primary calcemic hormones, 1,25-dihydroxyvitamin D₃ ...

Despite a series of persuasive experimental evidence for the involvement of eyes absent protein tyrosine phosphatases in various human cancers, no small-molecule inhibitor has been reported so far. We have identified seven novel inhibitors of eyes absent homologue 2 (Eya2) with IC(50) values ranging from 1 to 70??m by the virtual screening with docking ...

To determine the time required for the adaptive changes in human jejunal glycolytic enzyme activity, 3 volunteer subjects were fed isocaloric diets in which the carbodydrate either was entirely glucose or sucrose or was absent. When the dietary carbohydra...

A case of Rhizopus osteromyelitis is described. The radionuclide and radiographic findings differ from those of osteomyelitis secondary to common pathogens: low-level radionuclide activity is observed, while soft-tissue swelling, periosteal reaction, and loss of fascial margins are absent.

1st grade. Present Globe at Night to 2 first grade classes. ... Globe at Night Family Activity Packet 35 (All students and teachers, plus 1 for an absent ...

A discrete region of low or absent activity during /sup 99m/Tc-DTPA scanning in the left suprarenal area, simulating an avascular mass on renal imaging or radionuclide angiography, can result from dilatation of the gastric fundus. (auth)

... Absent in 1% Caucasians and African-Americans. Primary metabolism of: Most NSAIDs (including COX-2); S-warfarin (the active form); Phenytoin. Inhibited by: ...

resulting in absent or defective enzyme activity have been associated withRodeheffer and Shur 2002 Ehlers-Danlos; Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning

... of lizards seen within a 5-m wide belt (2.5 m each side of the progression line). This census belt width allowed us to detect all active lizards, ... but it is absent from the surrounding forested belt an...

A meta-analysis was based on every available study that has compared father-present and father-absent children on a measure of sex typing. 67 studies produced 222 estimates of effect size. Owing to the inappropriateness of conventional statistics, Hedges's approach to meta-analysis was employed. Results show that published studies produced larger estimates of effect size than ...

The active form of vitamin D₃, 1,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃, or calcitriol), is a potent mitogen for fibroblasts cultured from rat lungs at postnatal day 4 (P4), during the peak of septation (P3 to P7). In light of the key role of fibroblasts in alveolar septation, the authors ...

Vitamin D metabolites and its less-calcemic analogs (vitamin D compounds) are beneficial for bone and modulate cell growth and energy metabolism. We now analyze whether 25(OH)D(3) (25D), 1,25(OH)(2)D(3) (1,25D), 24,25(OH)(2)D(3) (24,25D), JKF1624F(2)-2 (JKF) or QW1624F(2)-2 (QW) regulate lipooxygenase (LO) mRNA expression and its products; hydroxyl-eicosatetraenoic acid (12 ...

20-Epi-1,25-dihydroxyvitamin D₃ (20-epi-1,25(OH)₂D₃) is a vitamin D analog that exhibits unique biologic properties. The mechanism(s) responsible for these activities remains unclear. Here we explore the ability of 20-epi-1,25(OH)₂D₃ to induce ...

All /sup 99m/Tc-DTPA studies of renal transplant patients whose grafts infarcted during a three-and-one-half-year period were reviewed. Four patients demonstrated absent renal perfusion and clearance and absent bladder activity. Three of these exhibited increased perinephric /sup 99m/Tc-DTPA activity and never ...

The Eyes Absent (Eya) proteins are tyrosine phosphatases and transcriptional activators involved in cell-fate determination and organ development. Mutations in the gene encoding Eya homologue 1 have been implicated in the multi-organ developmental disorder branchio-oto-renal syndrome (BOR) and in ocular defects. Here we report that BOR-associated mutations ...

The spectral properties of a sample of 58 Active Galactic Nuclei (AGN) spectra, in which emission [O III] ??4959, 5007 � lines are weak or totally absent, are analyzed. In order to investigate the physical reason for the [O III] emission suppression, the spectral properties of the weak [O III] spectra sample are compared with the same properties of a ...

In evaluating alcoholic liver disease in a patient with pulmonary tuberculosis, a liver-spleen scan was performed that showed an unusual uptake of sulfur colloid in the lungs. There was diffuse uptake in the left lung and portions of the right lower lung with absent uptake in the right upper lobe and portions of the right lower lung corresponding to areas of pulmonary ...

Sustained attention was studied in children with attention deficit hyperactivity disorder (ADHD) and normal controls using a continuous performance task with slow presentation of stimuli and carried out with an experimenter-present and absent condition. Children with ADHD were slower than controls, with performance deteriorating over time, particularly in the ...

Lung metastatic neoplasms are the major cause of cancer mortality. Despite the progress of diagnostic techniques and improvements in surgical procedures, the prognosis of patients with lung cancer is generally poor, even in the early stages of cancer [Cancer: Principles and Practice of Oncology, vol. 1, fifth ed., Lippincott-Raven, New York, 1997, p. 849]. Epidemiological studies indicate a ...

1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) is a powerful differentiation agent, which has potential for treatment of myeloid leukemias and other types of cancer, but the calcemia produced by pharmacologically active doses precludes the use of this agent in the clinic. We have shown that carnosic acid, the major rosemary polyphenol, enhances the differentiating and ...

1?,25-dihydroxyvitamin D₃ (1,25D₃) is a powerful differentiation agent, which has potential for treatment of myeloid leukemias and other types of cancer, but the calcemia produced by pharmacologically active doses precludes the use of this agent in the clinic. We have shown that carnosic acid, the major rosemary polyphenol, ...

Gallium nitrate (GaN) reduces cancer-related hypercalcemia and inhibits bone resorption in vitro. This study investigated the effects of chronic GaN administration on bone, kidney, and parathyroid gland activity of growing rats. Experimental animals received GaN (1.75 mg elemental gallium i.p. QOD X 8, Ga+), and controls received the solvent (Ga-). In the bone of Ga+ rats the ...

Starch gel electrophoresis of extracts from developing maize (Zea mays L.) endosperms 22 days postpollination reveals only a single zone of phosphoglucomutase activity in the majority of the inbreds tested. The other inbreds had the expected two zones of activity. The activity that is present in all inbreds is the amyloplast isozyme ...

Mature `Bartlett' pear (Pyrus communis) fruits were ripened at 20 C. Fruits at different stages of ripeness were homogenized, and extracts of the low speed pellet (crude cell wall) were prepared. These extracts contained polygalacturonase, pectin esterase, and activity against seven p-nitrophenyl glycoside substrates. Polygalacturonase, ?-galactosidase, and ?-mannosidase ...

... taken by mouth) are used. Decreased or absent sweating: If sweating is reduced or absent, avoiding warm ...

Skeletal muscle wasting is an important public health problem associated with aging, chronic disease, cancer, kidney dialysis, and HIV/AIDS. 1,25-Dihydroxyvitamin D (1,25-D3), the active form of vitamin D, is widely recognized for its regulation of calcium and phosphate homeostasis in relation to bone development and maintenance and for its calcemic ...

Urinary kallikrein activity and plasma renin activity (PRA) in supine and erect positions were determined in 22 men occupationally exposed to lead. In eight of them, suffering from hypertension and/or nephropathy, urinary kallikrein activity was low or absent, while PRA was normal or reduced. The other fourteen ...

20-hydroxyvitamin D(2) [20(OH)D(2)] inhibits DNA synthesis in epidermal keratinocytes, melanocytes, and melanoma cells in a dose- and time-dependent manner. This inhibition is dependent on cell type, with keratinocytes and melanoma cells being more sensitive than normal melanocytes. The antiproliferative activity of 20(OH)D(2) is similar to that of 1,25(OH)(2)D(3) and of newly ...

The purpose of this study was to describe the frequency of absent, unrecognized, or minimal myotonic discharges (MDs) in myotonic dystrophy type 2 (DM2). We performed a retrospective review of needle electromyography (EMG) data prior to genetic diagnosis in 49 DM2 patients at the Mayo Clinic. MDs were not reported on first or repeat EMG studies (n = 8) and not found in ...

BackgroundThe 1?,25-dihydroxy-3-epi-vitamin-D₃ (1?,25(OH)₂-3-epi-D₃), a natural metabolite of the seco-steroid vitamin D₃, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription regulator. In vivo action of ...

The total mutagenic activity of chemical pollution of the water taken from the Volga water reservoir was investigated after its treatment with chlorine and ozone. The toxicity of the water was absent after its ozone treatment. Mutagens were found to form after water chlorination. Their levels can be reduced by subsequent treatment with ozone in a dose of ...

This invention refers to the preparation for elimination of neuropathies in diabetes. The preparation contains a combination of minerals and plant extracts. By its ionic exchange, the invention reduces considerably the process of apoptosis of nerve-cells, eliminates the process of activation of the immunologic system, and stops the immunologic reaction of auto-destruction of ...

We graph equations to find where the line lies on the graph and thus are able to use this information to see or predict where it will cross at any given point. If you were absent or need a review you can watch the tutorial videos in our Holt on line text or you can read through this site. graphing equations tutorial If you need a review of the quadrants and points of the ...

In patients with nonprostatic cancer, serum acid phosphatase activity is usually elevated when bone metastasis is present but not when bone metastasis is absent. The fraction responsible for serum enzyme elevation is a normal component of serum; it appears in gel electrophoresis as band 5; and is tartrate-resistant. It is suggested that the origin of acid ...

The localization of the aldolase B isozyme was determined immunohistochemically in rat kidney and liver using a polyclonal antibody. Aldolase B was preferentially localized in a nuclear region of hepatocytes from the periportal region and was absent in those from the perivenous region. Aldolase B was also preferentially localized in the proximal tubules and was ...

SummaryEyes absent (Eya), named for its role in Drosophila eye development but broadly conserved in metazoa, possesses dual functions as a transcriptional coactivator and protein tyrosine phosphatase. While Eya�s transcriptional activity has been extensively characterized, the physiological requirements for its phosphatase activity ...

Eyes absent (EYA) has tyrosine- and threonine-phosphatase activities in their C-terminal and N-terminal regions, respectively. Using various mutants of mouse EYA3, we showed that the 68-amino acid domain between positions 53 and 120 was necessary and sufficient for its threonine-phosphatase activity. Point mutations were then ...

Delayed or absent tooth formation; Teeth - delayed or absent formation ... of teeth varies. Most infants get their first tooth between 6 and 9 months, although earlier or ...

The bare lymphocyte syndrome is a rare combined immunodeficiency disorder associated with the absence of class I and/or class II major histocompatibility (MHC) antigens. Although it has been inferred that the immune deficiency is a consequence of disordered MHC-restricted interactions among otherwise normal cells, the biological capabilities and differentiation of B lymphocytes deficient in class ...

Intense and very intense reactions were obtained for acid phosphatase, calcium activated ATP-ase (pH 9.4), magnesium activated ATP-ase (pH 7.2) and glucose-6-phosphatase in the cytoplasms of the myenteric plexus nerve cells of the small intestine of Macacus rhesus and rabbit. Nucleotidase activity was moderate or slight and unspecific ...

Intense and very intense reactions were obtained for acid phosphatase, calcium activated ATP-ase (pH 9.4), magnesium activated ATP-ase (pH 7.2) and glucose-6-phosphatase in the cytoplasms of the myenteric plexus nerve cells of the small intestine of Macacus rhesus and rabbit. Nucleotidase activity was moderate or slight and unspecific ...

Introduction:? The glucose-6-phosphate dehydrogenase (G6PD) fluorescent spot test (FST) is a useful screening test for G6PD deficiency, but is unable to detect heterozygote G6PD-deficient females. We sought to identify whether reporting intermediate fluorescence in addition to absent and bright fluorescence on FST would improve identification of mildly deficient female ...

Arthrogryposis is a condition characterized by symmetric, nonprogressive joint contractures and weak or absent musculature that is present at birth. The amyoplasia form is the most common, and in this group, the elbow is frequently involved, typically in an extension contracture bilaterally. Active elbow flexion is weak or absent, but ...

Retinal determination genes are sufficient to specify eyes in ectopic locations, raising the question of how these master regulatory genes define an eye developmental field. Genetic mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, ...

Retinal determination genes are sufficient to specify eyes in ectopic locations, raising the question of how these master regulatory genes define an eye developmental field. Genetic mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, ...

Motor nerve conduction studies (MNCS) and blink reflexes (BR) were done on a 42-year-old female patient who presented with peripheral facial nerve palsy (PFNP); these investigations were done while she had her facial muscles relaxed ("A"), and contracted ("B"). While in the "A" state, MNCS of the facial nerves had prolonged latency and low amplitude and R3 of the blink reflex was ...

Echinococcus multilocularis Leuckart, 1863, is reported from Neotoma cinerea rupicola Allen in Wyoming. This report represents new host and locality records for the cestode. The larva had undergone active multilocular vesiculation in the liver with minimal host-tissue reaction. Protoscolices and calcareous corpuscles were absent. PMID:907044

Turkey is one of the countries in which Crimean-Congo hemorrhagic fever is frequently seen and most of the cases are reported between April and August. We describe the first case of Crimean-Congo hemorrhagic fever in the winter season, when Hyalomma tick activity is absent, from Turkey. PMID:20948224

of magnetoencephalography (MEG) during passive listening to a regular musical beat with occasional omission of single tones synchronized with the stimulus. The decrease was absent after omissions. In contrast, -band activity showed a peak after tone and omission, suggesting underlying endogenous anticipatory processes. We propose

The most emotionally absent students often come alive after school. Any extracurricular activity (even football) seems better than high school. In football, teenagers are important contributors, are encouraged to excel, and become team players; repetition is honorable; the unexpected happens; practices run longer than 50 minutes; emotions and human contact ...

SOYBEAN RUST FUNGICIDE DECISION GUIDELINES (revised 6/2007) SOYBEAN RUST STATUS (Risk determined by national, regional and local activity and disease forecasts) RUST ABSENT RUST PRESENT SOYBEAN RUST RISKa NOT RECOMMENDED FOR SOYBEAN RUST CONTROL R1 (beginning of flowering) through R5 (beginning seed) Donotspray

In this paper the results of research of uranium containing lasants on the basis of phosphorus oxychloride made in accordance with our technology are presented. It is shown that U(IV)-impurities in these lasants are absent. The inactive loss coefficient o...

.nylander@sics.se ABSTRACT Information technology has not yet fully penetrated the work with pre-school children. We have of young children is by tradition a low tech activity where even common technology such as email is rarely-school and in the home which means that information problems arise when children are absent from pre-school or the family

by the worm germline tumors. In this regard, the fact that mice mutant for PTEN--a tumor suppressor bepivotaltoregulatingtumorgrowthincancers inwhichtheinsulin/IGF-1pathwayisaberrantly activated or in which PTEN is inactivated involve mutations affecting both the proteins of the PTEN-FOXO pathway and p53, exploring the reciprocal

Absent from discussions of Malcolm X's contribution to the modern black freedom movement is his critique of black education, which was based on his life experiences. Explicates his critique of major educational issues facing blacks during the height of his leadership in the 1950-60s. Illuminates the importance of situating Malcolm X within the historical tradition of black ...

exist. Abbreviations: EST, expressed sequence tag; ncRNA, noncoding RNA; SSR, simple sequence repeat-takusans, are expressed in the mouse brain and regulate synaptic activity [49]. Speer/a-takusan genes are absent from sequences, in contrast to protein-coding genes. Of 3,051 well-documented mouse long ncRNA sequences [63

integrins23. As a `readout' of integrin-mediated macrophage activation, we used biochemical analysis of Erk kinase (Fig. 7b). Adhesion- dependent Erk phosphorylation was absent from DF double-knockout macrophages-type Syk in Syk-knockout macrophages restored adhesion-dependent Erk phosphorylation, whereas compar- able

Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress. PMID:21909526

BackgroundRecent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma.Methodology/Principal FindingsWe crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mice. Both constitutive and conditional Pten deficiency doubled the incidence of mice ...

A concise review of the status of research on short-lived nuclei is presented. The importance of these nuclei is very great in spite of the fact that they are essentially absent today (except for cosmic-ray products). The significance of these nuclei for understanding broader cosmic problems is outlined and it is shown that they are a key to the earliest processes in solar ...

Treatment of sonic submitochondrial particles with the bifunctional thiol reagent, diamide, results in an enhancement of proton conductivity and ATPase activity, which is reversed by the reducing agent dithiothreitol, is suppressed by Fo inhibitors like oligomycin and is absent in particles that are deprived of peripheral Fo polypeptides. The effect of ...

electric �eld, but information on these parameters is absent in some cases. A list of the rocket �ights not contradict the existence of the V/m vertical electric �elds, if we assume the parameters for the more massive electric �elds and related parameters, J. Atoms. Terr. Phys., 56, 321�335, 1994a. Zadorozhny, A. M., V. N

as the basis for systematic test case design. Table 2. Testing Course Outline 1 Course Overview 2 Software, testing is virtually absent from the undergraduate curriculum. The goals of this effort are three-fold: (1 curriculum. We describe past and on-going activities aimed at achieving these goals. 1. INTRODUCTION Software

The activity of telomerase has been shown to be absent in normal somatic cells, with the exception of stem cells. The reactivation of telomerase has been seen as an early event in most cancers, especially breast cancer. I have shown that the inhibition of...

13. Abstract (Maximum 200 Words) (abstract should contain no prnpnetary or confidential information) The activity of telomerase has been shown to be absent in normal somatic cells, with the exception of stem cells. The reactivation of telomerase has been ...

Telomerase, a ribonucleoprotein reverse transcriptase, has been detected in reproductive cells, immortal cell lines, and most cancer cells. The activity of telomerase has been shown to be absent in normal somatic cells, with the exception of stem cells. T...

Streptococcus salivarius 57.I is one of the most abundant and highly ureolytic bacteria in the human mouth. It can utilize urea as the sole nitrogen source via the activity of urease. Complete genome sequencing of S. salivarius 57.I revealed a chromosome and a phage which are absent in strain SK126. PMID:21914897

harnessed to boost the activity of catalysts. Scientists have used the method to increase the amount to the catalyst surface bound to the surface most easily, boosting reactivity by 60%, compared with when the C in GO for metabolism when oxygen is absent in the environment (ACS NANO, doi:10.1021/nn101081v

, comparison of the crystal structures for the fusion protein ectodomains of HTLV-1 [20], MoMLV [29], Ebola [24MOF) and Ebola (purple, PDB ID 2EBO). Alpha helices are shown as cartoons, conserved Asn367 (BLV co, the chloride ion is present within the post-fusion conformation of Ebola GP2 (30), but is conspicuously absent

Human SWI/SNF complexes are ATP-dependent chromatin remodelers that play fundamental roles in the regulation of cell growth, development and tumor suppression. p270 is an integral member of these complexes and is absent in approximately 10% of breast tumo...

evaluations and APOE genotyping. Serum, plasma and DNA are stored for future analyses. Subgroups of WRAP presented here. DESIGN: 2X2 FACTORIAL Parental history status (present/absent) and APOE 4 status. BRAIN of APOE. Johnson et al. (in press), Archives of General Psychiatry. Face recognition strongly activates

Congenital sucrase-isomaltase deficiency (CSID) is characterized by absence or deficiency of the mucosal sucrase-isomaltase enzyme. Specific diagnosis requires upper gastrointestinal biopsy with evidence of low to absent sucrase enzyme activity and normal histology. The hydrogen breath test (BT) is ...

activity. No musculature exists in the antenna flagellum and so efferent (motor) neurons are absent and escape [14], [20]. The remaining segments are called the flagellum--the long, #12;132 IEEE TRANSACTIONS in neural recordings [15]. Camhi and Johnson [2] empirically demonstrated that receptors on the flagellum

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disease due to ECGF1 gene mutations causing thymidine phosphorylase (TP) deficiency. Analysis of post-mortem samples of five MNGIE patients and two controls, revealed TP activity in all control tissues, but not in MNGIE samples. Converse to TP activity, thymidine and ...

Eel pancreatic acetone powder was extracted with an acetone-water-HCL mixture. An acid acetone powder was formed by addition of a copious volume of cold acetone to the extract. The powder was subsequently subjected to gel filtration on Sephadex G25. Opiate receptor binding activity was present mainly in fractions retarded on Sephadex G25 (MW less than 5,000) although some ...

A technique for the isolation and the purification of Capsicum annum L. var. Yolo Wonder chromoplasts is described. The degree of purity of the isolated chromoplasts is greatly improved by the absence of MgCl₂ in the extraction medium and in the gradient purification system, as shown by electron micrographs and the near absence of antimycin-insensitive NADH:cytochrome c ...

Monopolar needle electromyogram (EMG) was recorded simultaneously from trapezius myofascial trigger points (TrPs) and adjacent nontender fibers (non-TrPs) of the same muscle in normal subjects and in two patient groups, tension headache and fibromyalgia. Sustained spontaneous EMG activity was found in the 1-2 mm nidus of all TrPs, and was absent in ...

The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition receptors that ...

The kinetics of x-ray-induced single-strand break rejoinirg have been studied in wild-type M. radiodurans and a radiosensitive mutant, UV17. The initial fast rejoining reaction observed in wild-type cells in growth medium was absent in UV17. Studies in which irradiated cells were allowed to repair under various conditions confirm that a buffer-mediated rejoining ...

Active materials that can solubilize in different compartments of a sample show release properties which might be of interest in some applications where a delayed release of solutes for instance is required. We studied perfume solutes in compartments of Pluronic block copolymers of different compositions and molecular weights over a range of ethanol-water mixtures. Phase ...

ObjectiveDifferentiation therapy with the hormonal form of vitamin D, 1?,25-dihydroxyvitamin D₃ (1,25D₃), is a promising approach to treatment of acute myeloid leukemia (AML); however, 1,25D₃ induces hypercalcemia at pharmacologically active doses. We investigated the in vitro and in vivoantileukemic efficacy ...

Calcitriol (1,25(OH)₂D3) is cytostatic for prostate cancer (CaP) but had limited therapeutic utility due to hypercalcemia-related toxicities, leading to the development of low-calcemic calcitriol analogs. We show that one analog, 1?-hydroxyvitamin D5 (1?(OH)D5), induced apoptosis in castration-sensitive LNCaP prostate cancer cells but, unlike calcitriol, ...

SummaryWe conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine different chemical scaffolds and 20 singletons. We found that agonists strongly potentiated TRPML3 activation ...

The many health benefits of regular physical activity underline the importance of this topic, especially in this period of time when the prevalence of a sedentary lifestyle in the population is increasing. Physical activity levels are especially low in patients with chronic obstructive pulmonary disease (COPD). Regular physical ...

The bone scans of 33 patients (pts) with recent subcapital fractures (fx) of the femur were evaluated prospectively to determine their value in predicting femoral head visability. Each of the 33 pts (ll men, 22 women, age range 30-92) had a pre-operative bone scan within 72 hrs of the fx (23 pts within 24 hrs). Anterior and posterior planar views of both hips and pinhole views (50% of pts) were ...

The Eyes Absent (EYA) proteins combine transactivation, tyrosine phosphatase and threonine phosphatase activities in their role as part of a conserved regulatory cascade involved in embryonic organ development. EYA tyrosine phosphatase activity contributes to fly eye development, and vertebrate EYA is involved in promoting DNA damage ...

Bungarotoxin present in Bungarus caeruleus (BC) causes life threatening respiratory muscle paralysis. Deep coma and hypokalaemia have been observed in a significant proportion of patients, but the cause is unknown. We postulate the likely mechanism behind these two phenomena. We studied clinical details of two patients admitted with deep coma and performed electroencephalograms (EEG) and brain ...

Bungarotoxin present in Bungarus caeruleus (BC) causes life threatening respiratory muscle paralysis. Deep coma and hypokalaemia have been observed in a significant proportion of patients, but the cause is unknown. We postulate the likely mechanism behind these two phenomena. We studied clinical details of two patients admitted with deep coma and performed electroencephalograms (EEG) and brain ...

All of 14 serotype standards and 34 of 35 wild-type strains of Ureaplasma urealyticum isolated from humans demonstrated an immunoglobulin A (IgA) protease activity. This activity degraded radiolabeled human IgA including IgA1 but not IgG or azocasein. The IgA fragments were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, followed by ...

Minimal absent words have been computed in genomes of organisms from all domains of life. Here, we explore different sets of minimal absent words in the genomes of 22 organisms (one archaeota, thirteen bacteria and eight eukaryotes). We investigate if the mutational biases that may explain the deficit of the shortest absent words in ...

O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the transfer of a single GlcNAc to the Ser or Thr of nucleocytoplasmic proteins. OGT activity, which may compete with that of kinases, is involved in signaling in animals and plants, and abnormalities in OGT activities have been associated with type 2 diabetes. Here, we show that ogt genes that ...

SummaryLong Interspersed Element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of highly active or �hot� L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 full-length L1s which are ...

Macrophages respond to cytosolic nucleic acids by activating cysteine protease caspase-1 within a complex called the inflammasome. Subsequent cleavage and secretion of proinflammatory cytokines IL-1? and IL-18 are critical for innate immunity. Here, we show that macrophages from mice lacking absent in melanoma 2 (AIM2) cannot sense cytosolic ...

Theophylline increases the synthesis of alkaline phosphatase in normal Hamster fibroblasts (activity X6 after 24 hours with theophylline 10-3 M). The enzymatic activity of these cells is inhibited by theophylline in vitro (80% inhibition in the presence of theophylline 10-3 M). The inhibition seems to be non competitive, since the apparent Km of the enzyme ...

Previously we put forward a hypothesis about the role of FOXO-dependent mechanisms of stress-response gene activation after irradiation in radiation hormesis (Moskalev, 2008). To testify this assumption we analyze the influence of gamma-irradiation on duration of larvae development and imago lifespan in Drosophila strains with different FOXO function ...

A 75-year-old man with prostate adenocarcinoma had a baseline FDG PET/CT that demonstrated increased left parotid and absent right parotid activity. The CT revealed fat in the right parotid space and enlargement of the left parotid gland. There was no history of dry mouth. Agenesis of one or more of the salivary glands is extremely rare with only few ...

Sulfur-resistance coefficients were found for unsupported nickel molybdates and nickel-molybdenum catalysts supported on type Y zeolite. The electron-promoting effect is absent for the systems studied. The Auger spectroscopic results indicate that the greater activity of the Ni-Mo bimetallic zeolite catalysts relative to nickel zeolite catalysts is ...

Childhood obesity is a significant public health concern. Since 1960, the prevalence of childhood obesity in the United States increased dramatically from 5% to 16.9%. To date many interventions to address obesity in schools have focused on healthy changes to the content of vending machines, school lunches, and the addition of after school activities to increase physical ...

We investigated whether the lower fatigue resistance in smokers than in nonsmokers is caused by a compromised muscle oxidative metabolism. Using calibrated histochemistry, we found no differences in succinate dehydrogenase (SDH) activity, myoglobin concentration, or capillarization in sections of the vastus lateralis muscle between smokers and nonsmokers. The relationship ...

An active neutron interrogation system utilizing the differential die-away technique (DDT), was built to assay fissile material in small waste packages for a variety of matrices. Within minutes the system can make a ``go/no-go`` decision for sorting low-level waste (LLW) from transuranic waste (TRUW). It can also provide gram-level accountability of weapons-grade (WG) Pu in ...

This paper presents a framework for weighted fusion of several Active Shape and Active Appearance Models. The approach is based on the eigenspace fusion method proposed by Hall et al., which has been extended to fuse more than two weighted eigenspaces using unbiased mean and covariance matrix estimates. To evaluate the performance of fusion, a comparative ...

In the aureole of the Beinn an Dubhaich granite, Skye, the minimum observed median forsterite-calcite-calcite dihedral angle varies from 110� at the olivinein isograd to about 165� (the equilibrium value) at the granite-limestone contact. Laboratory experiments were performed to investigate the kinetics of this textural change. It was found that the rate of change of the ...

We identified eight bands by staining the native gels for NADPH-nitroblue tetrazolium oxidoreductase activity after electrophoresis of n-dodecyl-�-maltoside-treated membranes of Synechocystis sp. strain PCC 6803. Among them, bands A, C, D and E were attributed to the activity of NADPH dehydrogenase (NDH-1). Band A is a highly active ...

A middle-aged woman presented with fatigue and mild increases in hematocrit and red cell mass. Polycythemia vera was diagnosed. She underwent therapeutic phlebotomy but clinically worsened. On reevaluation, other problems were noted including episodic malaise, nausea, rash and vasomotor issues. The JAK2V617F mutation was absent; paraneoplastic erythrocytosis was investigated. ...

Drosophila eye specification and development relies on a collection of transcription factors termed the retinal determination gene network (RDGN). Two members of this network, Eyes absent (EYA) and Sine oculis (SO), form a transcriptional complex in which EYA provides the transactivation function while SO provides the DNA binding activity. EYA also ...