Pharmacologic stress testing with dipyridamole is useful in patients undergoing thallium-201 myocardial perfusion scintigraphy who cannot adequately exercise. Because dipyridamole increases coronary blood flow by reducing the metabolism of adenosine, the authors compared the uptake and clearance of T1-201 following exercise stress testing (EST) and resting ...

Increasing blood pressure has a continuum of adverse risk for cardiovascular events. Traditionally this single measure was used to determine who to treat and how vigorously. However, estimating absolute risk rather than measurement of a single risk factor such as blood pressure is a superior method to identify who is most at risk of ...

There are several limitations in using absolute myocardial clearance of thallium-201 for the detection of coronary artery disease. Noncardiac factors such as peak exercise heart rate and blood level of thallium can affect its absolute myocardial clearance. However, because all ...

Quantification of myocardial blood flow is useful for determining the functional severity of coronary artery lesions. With advances in MR imaging it has become possible to assess myocardial perfusion and blood flow in a non-invasive manner by rapid serial imaging following injection of contrast agent. To date most ...

Heart failure represents a common disease affecting approximately 5 million patients in the United States. Several conditions play an important role in the development and progression of heart failure, including abnormalities in myocardial blood flow and sympathetic innervation. Nuclear imaging represents the only imaging modality with sufficient ...

Chronotherapeutics is advancing hypertension treatments beyond once-daily dosing by synchronizing the maximum levels of medication during times when cardiovascular risk is highest. It has long been established that patients are at higher risk for cardiovascular events-including myocardial infarction, stroke, and sudden death-in the early morning hours. Using novel oral ...

... Myocardial ischemia is associated with a reduction of coronary blood flow to the myocardium [1], and the damage to the myocardium may be a ...

Positron-emission computed tomography (PCT) is a new means of studying regional myocardial metabolism. This new device permits quantitative, cross-sectional imaging of the tissue concentrations of positron-emitting tracers of blood flow and metabolism in the myocardium. To examine the potential value of PCT for evaluating regional alterations in ...

The role of hypertonic solutions in altering infarct size, regional myocardial blood flow and contractility during acute and chronic myocardial ischemia in animals has been defined. The results are: (1) Hypertonic mannitol improves regional myocardial blo...

Using special hypokinetic cages, the volume changes of circulating blood, its hematocrit and protein

... Descriptors : *BLOOD PRESSURE, *CARDIAC PATIENTS, *MYOCARDIAL INFARCTION, *CONGESTIVE HEART FAILURE, ILLNESS, HEART ...

The current status of roentgen videodensitometric techniques that provide an objective assessment of

Cold is thought to provoke angina in patients with coronary disease either by an increase in myocardial demand or an increase in coronary vascular resistance. We investigated and compared the effects of cold pressor stimulation and symptom-limited supine bicycle exercise on regional myocardial perfusion in 35 patients with stable angina and coronary ...

BackgroundQuantitative estimates of myocardial perfusion generally require accurate measurement of the arterial input function (AIF). The saturation of signal intensity in the blood that occurs with most doses of contrast agent makes obtaining an accurate AIF challenging. This work seeks to evaluate the performance of a method that uses a radial k-space ...

To study the influence of hypometabolism on evolving myocardial infarction in a model with intact autoregulation, we investigated 53 awake dogs after coronary artery occlusion. Severe hypothyroidism was induced by the intravenous administration of 131I. Animals were instrumented to obtain hemodynamic measurements, and regional myocardial ...

A novel method is presented for estimating regional myocardial blood flow (RMBF) using x-ray computed tomography (CT). Two major setbacks are removed from the existing methods; namely, the requirement for intra-arterial bolus injection of tracer, and the inability to determine regional volumes of tracer distribution when the corresponding partition ...

Therapy Refractory Myocardial Ischemia; Coronary Artery Disease; Unsuitable for Surgical or Percutaneous Revascularisation

The maximal exercise capacity of cardiac transplant recipients is reduced compared with that of normal subjects. To determine if this reduced exercise capacity is related to inadequate myocardial perfusion during exercise, myocardial perfusion was measured noninvasively with use of positron emission tomography and nitrogen (N)-13 ammonia. Twelve transplant ...

Metabolic substrate utilization of the human failing heart is an area of controversy. The purpose of this study is to directly quantify myocardial substrate utilization in moderately severe heart failure, type 2 diabetes and healthy controls using simultaneous coronary sinus and arterial blood sampling. Patients with heart failure (n?=?9, mean NYHA ...

... the establishment. (Total red blood cell product volume = weight of the RBC divided by the appropriate specific gravity. Absolute ...

... of mouse peripheral blood tested were total white blood cells and the absolute numbers of polymorphonuclear leucocytes, monocytes, lymphocytes ...

Myocardial uptake and washout of thallium-201 were studied in an experimental dog model in which regional blood flow to the posterior wall was varied by transient 2-minute occlusion of the circumflex coronary artery to produce transient ischemia and reactive hyperemia. Thallium-201 myocardial activity in a region of interest was ...

The influence of hypertonic mannitol on regional myocardial blood flow and ventricular performance was studied during acute myocardial ischemia in awake, unsedated and in anesthesized dogs and after myocardial infarction in awake unsedated dogs. Regional myocardial blood ...

To assess whether myocardial perfusion and viability could be estimated by dynamic K-38 (T1/2: 8 min) imaging with Positron Emission Tomography, closed chest dogs were studied after permanent (PERM; 8 studies) or during transient (TRANS; 7 studies) circumflex coronary occlusion. By using a two-compartment kinetic model, estimates of PET myocardial ...

The radioactive microsphere technique is tested for its applicability to the measurement of regional myocardial blood flow in the conscious baboon. Tests undertaken were: (1) the reproducibility of microsphere deposition densities, (2) recirculation of mi...

Positron emission computed tomography is a new technique for the noninvasive measure of myocardial blood flow, mechanical function and, in particular, metabolism. The capability of this new study means is due to the technological innovations of the imagin...

The effect of reopening acutely occluded coronary arteries has on regional myocardial blood flow and ultrastructure was studied in open chest dogs. Temporary and permanent ischemia were produced in the same animal by ligating a branch of the left anterior...

Changes in myocardial substrate utilization were studied following experimental coronary hypotension in the isolated heart of a small dog perfused with the blood of a large donor animal. Prolonged severe hypotension caused a decreased coronary sinus blood...

The recent interest in the role of the intestine in the cardiovascular stability of uremic patients, specifically on dialysis, but potentially also in chronic kidney disease, must be seen against the background of the recent great interest in the role of the gut in chronic heart failure [Curr Opin Clin Nutr Metab Care 2008;11:632-639]. There has been a long-standing interest in the role of the ...

The purpose of this study was to synthesize and evaluate /sup 11/C-MTP for use as a potential regional myocardial perfusion agent in positron emission tomography. The synthesis of /sup 11/C-MTP was accomplished by reacting triphenylphosphine with /sup 11/C- methyliodide. Triphenylphosphine was dissolved in benzene and cooled to O/sup 0/C in a septum sealed reaction vessel. ...

... glycogen depletion, nuclear chromatin margination and mitochondrial swelling) produced with 30 minutes of ischemia were reversed with reflow. ...

... Descriptors : *HEPARIN, REPRINTS, HEART RATE, DOGS, BLOOD PRESSURE, MYOCARDIUM, ISCHEMIA, CREATINE PHOSPHOKINASE. ...

... OF SIMULATED HIGH ALTITUDE ON LEFT CIRCUMFLEX CORONARY FLOW, BLOOD PRESSURE, CARDIAC OUTPUT, AND MYOCARDIAL ...

... A right shift of the oxygen dissociation curve (due to incorporation of inositol hexaphosphate into red cells) improved function and myocardial ...

Purrpose: To evaluate myocardial microvascular disease in patients with type 2 diabetes mellitus (DM) using myocardial contrast echocardiography (MCE) and to report on its diagnostic accuracy using single photon emission tomography (SPECT) as reference test. Methods: We prospectively enrolled 79 patients (25 DM; 66�11 years) who underwent simultaneous ...

Thallium-201 uptake and clearance after dipyridamole infusion may differ from that after exercise stress because the hemodynamic effects of these two interventions are different. In this study of normal volunteers, thallium kinetics after dipyridamole (n = 13) were determined from three serial image sets (early, intermediate and delayed) and from serial blood samples and ...

Cardiac 82rubidium dynamic PET studies allow quantifying absolute myocardial perfusion by using tracer kinetic modeling. Here, the accurate measurement of the input function, i.e. the tracer concentration in blood plasma, is a major challenge. This measurement is deteriorated by inappropriate temporal sampling, spillover, etc. Such ...

Anemia; Hematologic Diseases; Blood Transfusion; Cardiovascular Diseases; Heart Diseases; Myocardial Infarction; Thromboembolism; Pneumonia; Cerebrovascular Accident

Cardiac remodelling is commonly defined as a physiological or pathological state that may occur after conditions such as myocardial infarction, pressure overload, idiopathic dilated cardiomyopathy or volume overload. When training excessively, the heart develops several myocardial adaptations causing a physiological state of cardiac remodelling. These ...

of decline and nadir of peripheral blood absolute lymphocyte depletion. The "normal" range for absolute lymphocyte count can vary, even in a healthy adult population. See graph...

To evaluate radionuclide diastolic filling indices during acute pharmacologic changes in ventricular loading, 11 atrially paced dogs underwent simultaneous micromanometer left atrial and left ventricular pressure measurements. During phenylephrine infusion, systolic blood pressure increased from 110 +/- 16 (s.d.) to 147 +/- 19 mmHg (p < 0.01), causing the atrioventricular ...

The rate of clearance of myocardial carbon-11 (11C) activity (after the administration of 11C-acetate) has been shown to correlate closely with myocardial oxygen consumption. In the present study, we hypothesized that regional net myocardial uptake of 11C-acetate, which reflects primarily delivery and extraction of tracer, would be ...

1 The effects of papaverine on coronary blood flow, myocardial oxygen consumption, myocardial oxygen tension and the ischaemic ECG pattern were studied in anaesthetized open-chest cats representing three models of acute coronary insufficiency: ligation, spasm, and perfusion of the coronary artery at a stabilized insufficient level. 2 ...

Myocardial ischemia-reperfusion injury is a major cause of morbidity and mortality in developed countries. To date, the only treatment of complete ischemia is to restore blood flow; thus the search for new cardioprotective approaches is absolutely necessary to reduce the mortality associated with myocardial ...

Cigarette smoking is strongly associated with ischemic heart disease and acute coronary events. The effect of smoking a single cigarette on regional myocardial perfusion was studied in 13 chronic smokers with typical stable angina pectoris using positron emission tomography and rubidium-82 (/sup 82/Rb). Findings were compared with the effects of physical exercise. After ...

BackgroundHyperglycaemia is associated with poor outcomes from pneumonia, myocardial infarction and stroke, but the effect of blood glucose on outcomes from acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has not been established. Recent UK guidelines do not comment on measurement or control of blood glucose in ...

This study investigated the effects of alcohol septal ablation (ASA) on microcirculatory function and myocardial energetics in patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction. In 15 HCM patients who underwent ASA, echocardiography was performed before and 6 mo after the procedure to assess the LVOT gradient (LVOTG). ...

Eighty-eight patients admitted to a coronary care unit with chest pain of varying etiology but without ECG evidence of an acute transmural myocardial infarction had myocardial scintigrams using technetium-99m stannous pyrophosphate (/sup 99m/Tc-PYP). Seventeen of these patients had ECG and enzymatic evidence suggestive of acute subendocardial ...

⁸²Rb cardiac PET allows the assessment of myocardial perfusion using a column generator in clinics that lack a cyclotron. We and others have previously shown that quantitation of myocardial blood flow (MBF) and coronary flow reserve (CFR) is feasible using dynamic ⁸²Rb PET and factor and ...

The rationale for radioisotopic studies of regional myocardial blood flow is discussed. Among the topics included in the discussion are: the limitations of coronary arteriography; nonimasive screening for ischemic heart disease; radioisotope diagnosis of myocardial infarction; measurement of coronary blood ...

The unique physical properties of the freely diffusible gas krypton-81 m allowed continuous imaging of regional myocardial blood flow in dogs when infused into the aortic root. Regional changes in myocardial perfusion related to transient coronary artery occlusion were demonstrated both as high resolution gamma camera images and as a ...

Arterial Spin Labeled MRI Detects Increase in Myocardial Blood Flow with Adenosine Z. Zun1 , P applied myocardial ASL to the measurement of MBF at rest and during an infusion of adenosine, which-pass perfusion imaging with adenosine. All experiments were performed on a GE Signa 3.0 T EXCITE HDx system

OBJECTIVE�To evaluate the combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after myocardial infarction.?DESIGN�Myocardial contrast echocardiography was performed in patients with acute myocardial infarction shortly after successful coronary ...

be useful for the detection of coronary artery disease (see Fig. 3). Myocardial Perfusion Imaging Figure 3 by a narrowing of the coronary arteries which deliver oxygen and nutrients to cardiac muscle (myocardium). IHD resonance imaging (MRI) of the coronary arteries and blood de- livery to the myocardium. Myocardial

Coronary heart disease leads to myocardial infarction and is a major cause of death in the US. Myocardial infarctions result from atherosclerotic plaque deposits in the coronary arteries, reducing blood flow through these arteries which supply oxygen and ...

Among the plasma lipids, cholesterol and trigly-cerides have been found as the major risk factors in atherosclerosis and myocardial infarction (MI). These lipids circulate in the blood in association with proteins as lipoproteins. Determination of lipopro...

Myocardial localization of /sup 201/Tl was compared with direct measurements of myocardial perfusion in normal, acutely ischemic, and recently infarcted myocardium. Studies were performed in 6 chronically instrumented dogs that were subjected to myocardial infarction by occlusion of the proximal left circumflex coronary artery. Four ...

The effects of low concentrations of carboxyhemoglobin (COHb) on coronary blood flow, myocardial oxygen consumption, and cardiac function were investigated in 10 conscious dogs. During the exposure there were significant decreases in the a-v difference in...

The effect of hypothermia of 25C for 24 hours on myocardial metabolism and efficiency was determined on dogs fasted for approximately 15 hours and anesthetized with sodium pentobarbital. Coronary blood flow, cardiac output, myocardial oxygen and substrate...

The straight chain radiolabeled fatty acid (FA) show relatively rapid myocardial washout since they could be metabolized by the beta-oxidation and undergo in vivo deiodination. The high levels of free radioiodide in blood requires a special background cor...

Changes in myocardial substrate utilization were studied after experimental coronary hypotension in the isolated dog heart perfused with the blood of a large donar animal. After a control period (100 mmHg) the afterload of the isolated heart was adjusted ...

Contents: Hemodynamic studies; Regional distribution of myocardial blood flow: Influence of mechanical and pharmacological assist following coronary artery ligation; Arterial oxygen in acute myocardial infarction; Hemoglobin affinity for oxygen; The relat...

Contents include: Hemodynamic effects of glucagon in power failure; Left ventricular catheterization in acute myocardial infarction; Right and left heart pressures in acute myocardial infarction; Coronary sinus blood flow in man; Urinary catecholamines, s...

Venckunas, T, Vasiliauskas, D, Marcinkeviciene, JE, Grizas, V, Stasiulis, A, and Malkova, D. Strongmen sport is associated with larger absolute heart size and impaired cardiac relaxation. J Strength Cond Res 25(X): 000-000, 2011-This study was carried out to compare cardiac structure and function and blood lipids among Strongmen, sedentary controls, and ...

Blood cardioplegia is worldwilde used during cardiac surgery. It provides a safe myocardial protection during this surgery. All along the year blood cardioplegia has been improved but it's of importance to apply it correctly. This can be a disadvantage during some cardiac surgery technics. PMID:21703481

Using special hypokinetic cages, the volume changes of circulating blood, its hematocrit and protein content, volume ratios between extra- and intracellular liquids in the body, as well as electrolyte content in the blood and myocardium during hypokinesia...

Serial, rapid measurements of left ventricular myocardial blood flow in trained, unanesthetized dogs have been made by injecting krypton-85 through chronically implanted coronary artery catheters and counting with an external scintillation detector. Precordial radioactivity declined as a single exponential function during the first 2 min after ...

Understanding the oxygen consumption of the left ventricular myocardium provides important insight into the relationship between myocardial oxygen supply and demand. In other territories, cardiac magnetic resonance has been utilized to measure myocardial oxygen consumption with a blood level oxygen dependent (BOLD) technique. The BOLD ...

Background and ObjectivesHyperacute rejection (HAR) is a major obstacle to successful xenotransplantation of vascularized organs. This study was conducted to observe the effect of hemolysis of perfused human whole blood on pig heart function, and determine the major risk factors for preservation of xenoperfused cardiac function using ex-vivo pig to human xenogeneic cardiac ...

BackgroundExperimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia.ObjectivesWe conducted this study to investigate the effects of concentrated ambient particles (CAPs) on myocardial blood flow during myocardial ischemia in ...

This study was done to determine the value of thallium-201 myocardial scintigraphic imaging (MSI) for identifying disease in the individual coronary arteries. Segmental analysis of rest and stress MSI was performed in 133 patients with ateriographically proved coronary artery disease (CAD). Certain scintigraphic segments were highly specific (97 to 100%) for the three major ...

Perfusion scintigraphy with thallium-201, infarct scintigraphy with technetium-99m pyrophosphate (TcPYP), and equilibrium blood pool scintigraphy were performed during the initial hospitalization for acute myocardial infarction (MI) in 25 patients without evidence of heart failure who presented with advanced electrocardiographic rhythm and conduction ...

The net myocardial accumulation of thallium-201 after injection depends upon the net balance between continuing myocardial extraction from low levels of recirculating thallium in the blood compartment and the net rate of efflux of thallium from the myocardium into the extracardiac blood pool. These experiments were ...

This study assesses the relationship between the distribution of thallium-201 and myocardial blood flow during coronary vasodilation induced by intravenous dipyridamole in canine models of partial and complete coronary artery stenosis. 10 dogs were chronically instrumented with catheters in the left atrium and aorta and with a balloon occluder and ...

A black blood gradient echo sequence for multiphase cardiac MRI of the mouse heart was implemented on a 4.7-T scanner and compared to a conventional bright blood sequence. Black blood was achieved using the double inversion recovery technique. Ten mice were imaged using both the bright and the black blood ...

... force due to coronary occlusion, reperfusion, and intervention. ... Evidence Based Review: Risk of Cardiac Rhythm Problems During Spaceflight ... Study are commonly used to predict the absolute risk of myocardial infarction (MI) and ...

In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular ...

To determine the myocardial uptake and retention properties of radioiodinated tellurium fatty acids, we prepared two new tellurium fatty acids in which iodine-/sup 125/ has been chemically stabilized by attachment as a trans-vinyl iodide (I-CH . CH-R-Te-R'-COOH) and evaluated them in rats. Fabrication of 18-iodo-13-tellura-17-octadecenoic acid was accomplished by ...

The aim of the present study was to investigate the changes in absolute myocardial blood flow (AMF) after intracoronary injections of mesenchymal SC (MSC) and compared to controls in closed-chest reperfused acute myocardial infarction (AMI) in pigs. Male MSCs, transiently transfected with Luciferase (Luc-MSC) were ...

. Cadaver blood was used initially [18], but soon blood for transfusion was only obtained from living donors accepted by the end of Word War I. The availability of donor blood from modern blood banks set the scene in 39 autologous blood donors undergoing elective complete ...

Regional myocardial blood flow before and after intravenous dipyridamole (0.56 mg/kg) was measured during cardiac catheterization in 11 patients using the /sup 133/Xe washout technique. Significant increases in heart rate and decreases in systolic blood pressure were observed with dipyridamole infusion. However, double product and ...

Cardiovascular Diseases; Heart Diseases; Lung Diseases; Hypertension; Diabetes Mellitus; Obesity; Coronary Disease; Myocardial Ischemia

Nov 24, 2008 ... Detection of acute myocardial damage rapidly and outside the hospital so that life-saving therapy can be administered for heart attack ...

A case of hypertrophied moderator band due to atrial septal defect is demonstrated on a resting thallium myocardial scan and a gated blood pool scan.

... divided. Ligatures were loosely placed around the thoracic aorta distal to ... pump prepared to draw blood from the aorta of the support dog. ...

... Liver disease. Renal disease. Cardiac disease ( hepatic blood flow). Acute myocardial infarction? Acute viral infection? Hypothyroidism or hyperthyroidism? ...

Propranolol has been evaluated as a prototype agent capable of reducing infarct size following experimental myocardial ischemia in dogs. Necrosis has been quantitated from histologic sections in hearts of groups of dogs after 40 minute of temporary corona...

The potential therapeutic usefulness and mechanism of action of the beta adrenergic blocking drug, propranolol is described in dogs with induced acute myocardial infarction. Results are evaluated by postmortem morphologic examination and distributions of ...

exp 18 F labeled 2-deoxyglucose ( exp 18 FDG) was studied as a glucose analog. Myocardial uptake and retention, blood clearance, species (dog, monkey, man) dependence and effect of diet on uptake were investigated. Normal myocardial uptake of exp 18 FDG w...

During the study of chest using positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG), a significant myocardial FDG uptake can prevent detection of the lesion that is located either behind or closely attached to the heart border. Two well-known and possible factors of myocardial FDG uptake are blood glucose level ...

The restructuring of cardiac innervation after myocardial ischemic injury, which is often associated with an increased sympathoexcitatory reflex characterized by an increase in blood pressure and sympathetic nerve activity. This study observed whether P2X(2/3) receptor in rat superior cervical ganglion (SCG) played a role in the increased ...

Thallium 201 myocardial perfusion imaging is a standard method of evaluating regional myocardial blood flow. Myocardial perfusion is best evaluated at rest and during exercise, however, alternative methods have been sought to increase coronary blood flow in patients incapable of performing ...

1. In anaesthetized cats, intravenous adenosine infusions decreased resistance to blood flow in the myocardial vascular bed. This effect of adenosine was augmented during the 60 min following the intravenous injection of dipyridamole (1 mg/kg). 2. In different experiments, intravenous infusions of noradrenaline caused either a slight increase or a slight ...

The routine use of sensor-tipped guide wires for the assessment of functional coronary lesion severity has become widespread in the catheterization laboratory. The physiological parameters derived from pressure or flow velocity measurements, fractional flow reserve, relative and absolute coronary blood flow velocity reserve show a high agreement with ...

The actions of (-)-verapamil (0.2-6 mg kg-1) and (+)-verapamil (0.4-12 mg kg-1) against arrhythmias induced by coronary artery occlusion were studied in conscious rats. Intravenously administered (-)- and (+)-verapamil dose-dependently reduced ventricular arrhythmias. (-)-Verapamil was consistently 4 times more potent than (+)-verapamil. In the same animals, (-)-verapamil was approximately 4 times ...

Six (/sup 203/Hg) hydroxymercurifluoresceins were prepared by two methods and compared with (/sup 3/H) fluorescein, (/sup 131/I) rose bengal, and (/sup 203/Hg) mercuric nitrate, in a rat model for myocardial necrosis, to determine their specificities for damaged myocardium (DM). The nonhalogenated (/sup 203/Hg) hydroxymercurifluorescein had the highest ratios of the series for ...

Coronary heart disease is the most common cause of death in the United States. The conventional risk factor approach to primary prevention excludes many patients who could benefit from preventive therapies. A global risk approach allows more accurate estimates of risk to guide clinical primary prevention efforts. Global risk of coronary heart disease is a calculation of the ...

... foot TOk Tail & Foot Blood Flow - absolute values 64 pg/kg Neuropeptide-Y so 50 ... 13 Page 20. Total Tail Blood Flow 64 pg/kg Neuropeptide-Y ...

Experimental cardiac tamponade was induced in anesthetized dogs by injection of isotonic solution of sodium chloride into the pericardium via a polyethylene catheter which was implanted before. Myocardial contractility was continuously recorded by using analog and digital computers. The pressure rise in the pericardium was accompanied by a significant growth of ...

We have studied the use of Tc-99m-labeled 2,3-dimercaptosuccinic acid(Tc-99m DMSA) to scintigraph acute myocardial infaction after coronary occlusion in dogs. Optimal images were obtained 5 hr after injection of radiotracer, with consistent delineation 48 hr after occlusion. Delivery of tracer was dependent on blood flow. Uptake of tracer correlated to ...

Our aim was to determine the effect of left ventricular assist device (LVAD) implantation on bypass graft patency and to measure myocardial oxygen consumption (MVO2) and blood flow during LVAD support. Five patients who underwent coronary artery bypass grafting and required LVAD implantation for post-cardiotomy cardiogenic shock had coronary angiography ...

The report was a study of postmyocardial infarction patients testing the hypothesis that physical exercise has a favorable effect upon the lipid structure and coagulation of blood, two factors the researchers felt to be among the leading causes of the pat...

The areas of technical effort were; the evaluation of circulatory assist devices in animals, the development of myocardial failure (ischemic) animal models, the evaluation of total heart replacement biventricular blood pumps, the evaluation of 'cup squeez...

Occlusions of the left circumflex coronary artery were performed before and after surgical denervation of sinoaortic baroreceptors in conscious, resting dogs. The removal of baroreceptors dramatically compromised arterial blood pressure maintenance. Mean ...

The kinetics and characteristics of nitrogen-13 labelled ammonia as an indicator of blood flow in the myocardium were evaluated in open-chest dogs. Its utility as an imaging agent was tested in animals and man. (PSB)

The kinetics and characteristics of nitrogen-13 labelled ammonia as an indicator of blood flow in the myocardium were evaluated in open-chest dogs. Its utility as an imaging agent was tested in animals and man.

The primary objective of the program was completion of the development of a rapid, semi-quantitative, visual spot test for screening creatine phosphokinase (CPK) activity in whole blood to serve as an aid in the diagnosis of myocardial infarction. Three l...

A brief review is given of research in the following areas: Cardiovascular diseases; blood banking procedures; cardiac intensive care units following myocardial infraction; transplantation and tissue compatibility. (Author)

Contents: Blood sugar and insulin response of humans in shock; Effects of myocardial ischemia on ventricular compliance; Increased oxyhemoglobin affinity after transfusion of stored blood--evidence for circulatory compensation; Effect of catecholamines on...

To assess the accuracy of spectral indices of arterial pressure variability and baroreflex sensitivity obtained from beat-by-beat noninvasive blood pressure recordings by the Finometer device, we compared these measures with those obtained from intra-arterial recordings. The performance of the Finometer was also compared to the traditional Finapres device. In 19 cardiac ...

(red), blood-myocardium CNR (green), as a function of actual flip angle. Figure 1: (top) measured with actual flip angles of (a) 16.6� and (b) 30� Experiment and Simulation-based Optimization of Blood-Myocardium high signal-to-noise ratio (SNR) and excellent blood-myocardium contrast [1]. In previous studies

There is a poor association between systemic blood flow and blood pressure in preterm infants in the first days of life. Very preterm babies can have early low systemic blood flow with poor myocardial contractility but normal blood pressure. Superior vena cava flow measured by echocardiography ...

A sixty-year old man with acute myocardial infarction was incidentally found to have a hypertrophied anterolateral papillary muscle (ALPPM) of the left ventricle on gated blood pool (GBP) and T1-201 myocardial perfusion images. Hypertrophy of the ALPPM was visualized as a movable defect in the lateral basal area on GBP imaging ...

The radioactive microsphere technique is tested for its applicability to the measurement of regional myocardial blood flow in the conscious baboon. Tests undertaken were: (1) the reproducibility of microsphere deposition densities, (2) recirculation of microspheres, (3) the effects of microsphere size and injection site on local microsphere depositions, ...

Myocardial perfusion scans (using $sup 131$Cs) and blood pool scans (/ sup 113m/In) were performed on a patient before and after resection of a left ventricular aneurysm. Although the hugh aneurysm was revealed by preoperative scans, preservation of a significant mass of myocardium was evident. Postoperative scans show the reconstructed heart and ...

High admission blood glucose levels after acute myocardial infarction are common and associated with an increased risk of death in patients with or without diabetes. Hyperglycemia is associated with altered myocardial blood flow and energetics and can lead to a pro-oxidative/proinflammatory state. The use of ...

Patients with acute myocardial infarction and heart failure are often anxious. Anxiety after acute myocardial infarction may cause in-hospital complications and increased mortality. Clinicians often use heart rate and blood pressure as indicators of anxie...

Technetium-99m t-butylisonitrile ((/sup 99m/Tc)TBI) is a promising new radiotracer for myocardial imaging. Its myocardial uptake is sufficiently high in humans to permit planar, tomographic, and gated images of excellent technical quality. We studied the behavior of (/sup 99m/Tc)TBI in the dog at rest and under conditions of hyperemia and reperfusion in ...

Little is known about regional myocardial blood flow and metabolism in the developing heart. Simultaneous estimates of regional myocardial blood flow and glucose metabolism have been made in the adult rat by Yonekura et al using ({sup 201}) Thallium (THAL) and ({sup 14}C)2-deoxyglucose (DG) autoradiography. Since ...

The Absolute Neutron Activation Analysis (ANAA) technique was used to determine element concentrations of Cl and Na in blood of healthy group (male and female blood donators), select from Blood Banks at Sao Paulo city, to provide information which can help in diagnosis of patients. This study permitted to perform a ...

In order to minimize the rate of inadequate myocardial revascularizations, an intraoperative evaluation of regional myocardial perfusion could have practical impact. Current bypass flow measurements have inherent limitations and can determine only epicardial blood flow. To analyze regional graft-dependent ...

The research aims were to test perception of arterial hypertension and myocardial infarction in hypertensive and normotensive men and women as well as to test perception of arterial hypertension and myocardial infarction as predictors of blood pressure control in hypertensives. In the research 470 subjects of 4 general practices from ...

AIMS: To determine if cardiac enzymes measured at necropsy could be used to predict early myocardial infarction. METHODS: Cardiac enzyme activities were measured in body fluids at necropsy. Coroners' necropsies were grouped by gross and microscopic findings into cases of definite myocardial infarction, cases with occlusive coronary artery atheroma but no ...

Myocardial perfusion imaging with thallium-201 and gated cardiac blood pool scanning are finding increasing use in clinical cardiology. These noninvasive techniques have been found useful in detecting myocardial infarction independent of the electrocardiogram and determining the site and extent of the infarct as well as its effect on ...

Eight patients with coronary heart disease and exertional angina pectoris successfully completed an 11-15 wk program of endurance exercise conditioning. Angina threshold was determined by upright bicycle ergometer exercise and by atrial pacing. The product of heart rate and arterial systolic blood pressure at the exercise angina threshold was higher after conditioning. ...

Recent times are witnessing a resurge of metabolic interventions in order to preserve myocardial tissue and improve cardiac function after hypoxic or ischaemic events. The basic principle of this therapeutic approach which differs completely from surgical and radiological revascularisation techniques as well as from direct pharmacologic stimulation of contractility by ...

Aims: Accelerated idioventricular rhythm (AIVR) is very frequently observed in primary percutaneous coronary intervention (PCI), however knowledge of the haemodynamic effects is lacking. Methods and results: We studied an ST-segment elevation myocardial infarction cohort of 128 consecutive patients (aged 62�11years) in whom AIVR occurred following reperfusion during primary ...

... in shunt fraction and an increase in V/Q inequalities.24 The observed ... the measurement device is designed for mammalian blood and that absolute ... ...

Immunophenotyping studies of peripheral blood lymphocytes indicated a significant decrease in the absolute number of B-cells, T-helper cells, ...

The authors suggest that in the course of reticuloplasmocytoma there need not always appear absolute dysproteinemia. The lack of albumin disturbances in blood serum may be explained by two mechanisms: (1) 'storage' of pathological albumin in the cytoplasm...

Intraocular tension. Fusional amplitudes. Absolute brightness threshold ... research investigations associated with manning and operating an earth orbital research ...... to provide room for larger instruments, such as a blood pressure ...

Effects of 12-month therapy with a beta1-adrenoblocker atenolol on the process of late postinfarction remodeling of the heart and parameters of intracardiac hemodynamics were assessed in an open noncomparative study on 55 survivors of macrofocal myocardial infarction. Therapy with atenolol was associated with: (1) reduction of myocardial hypertrophy in ...

Manganese, a trace metal, is known to localize in mitochondria. Because mitochondria are abundant in heart muscle, the possible utility of radioactive manganese as a myocardial imaging agent was examined in 25 rats and six dogs. Myocardial uptake of Mn-54 in rats was found to exceed that of thallium-201; myocardium-to-blood ratios ...

Myocardial perfusion measurements have traditionally been performed in a quantitative fashion using application of the Sapirstein, Fick, Kety-Schmidt, or compartmental analysis principles. Although global myocardial blood flow measurements have not proven clinically useful, regional determinations have substantially advanced our ...

Much has been written regarding the potential clinical significance of myocardial bridges. As such bridging is often seen in normal individuals, it is clear that not all arteries bridged by myocardial segments produce clinical symptoms thereby suggesting that this feature may simply be an anatomical variant. However, some authors who have considered these ...

We have demonstrated previously that the dielectric properties of myocardium at microwave spectrum are a sensitive indicator of its blood content, ischemia, and infarction. The purpose of this study is to validate the feasibility of microwave tomography for detection of myocardial infarction based on the differences in dielectric properties between normal ...

The myocardial clearance of rubidium may be obtained by praecordial counting after intravenous injection of Rb-minus 86 Cl. Eight patients with recent myocardial infarction had this determination performed before and after the infusion of 10 mg phentolamine at a rate of 0.3 mg/minute. The average predrug myocardial clearance of Rb was ...

The purpose of this study was to compare the myocardial distribution of thallium-201 and regional myocrdial blood flow during ischemia and the physiologic stress of exercise. Studies were carried out in six dogs with chronically implanted catheters in the atrium and aorta and a snare on the circumflex coronary artery distal to the first marginal branch. ...

Although acute myocardial infarction (AMI) is still one of the main causes of high morbidity in Western countries, the rate of mortality has decreased significantly. The main cause of this drop appears to be the decline of the incidence of ST-segment elevation myocardial infarction (STEMI) along with an absolute reduction in case ...

The role of structural and functional abnormalities of small vessels in diabetes cardiomyopathy remains unclear. Myocardial contrast echocardiography allows the quantification of myocardial blood flow at rest and during dipyridamole infusion. The aim of the study was to determine the myocardial ...

To derive a quantitative index of regional myocardial blood flow, the arterial input function of the flow tracer N-13 ammonia and the regional myocardial N-13 activity concentrations were noninvasively determined in 29 experiments in eight dogs. N-13 ammonia was administered intravenously and cross-sectional images were acquired ...

The effects of restraint stress on heart activity, blood catecholamines and the development of myocardial necrosis were studied in five unoperated and five unsuccessfully amygdalectomized (sham-operated) pigs and compared with six bilaterally amygdalectomized pigs. In the sham-operated and the nonoperated animals, restraint stress often provoked intense ...

ABSTRACT: Increases in blood lactate reflect decreases in systemic blood flows associated with low blood flow states characteristic of circulatory shock. Accordingly, the report by Vermeulen and colleagues documents the use of the blood lactate measurement as a prognostic indicator in settings of ST elevation ...

Single photon-emission computed tomography (SPECT) with /sup 99m/Tc-pyrophosphate (PPi) has been shown to estimate size of myocardial infarction accurately in animals. The authors tested the hypothesis that SPECT with /sup /sup 99m//Tc-PPi and blood pool subtraction can provide prompt and accurate estimates of size of myocardial ...

Function of the heart begins long before its formation is complete. Analyses in mouse and zebrafish have shown that myocardial function is not required for early steps of organogenesis, such as formation of the heart tube or chamber specification. However, whether myocardial function is required for later steps of cardiac development, such as endocardial ...

Function of the heart begins long before its formation is complete. Analyses in mouse and zebrafish have shown that myocardial function is not required for early steps of organogenesis, such as formation of the heart tube or chamber specification. However, whether myocardial function is required for later steps of cardiac development, such as endocardial ...

To determine whether branched chain fatty acid extraction is reduced during right ventricular (RV) dysfunction due to acute pulmonary artery hypertension, studies were done in 6 anesthetized dogs. Regional branched chain fatty acid extraction was measured by comparing the myocardial uptake of I-125 labeled 15-(p-(iodophenyl))-3-methylpentadecanoic acid (I-PDA) to ...

We postulated that {sup 99m}Tc-Q3, a cationic imaging agent, produces myocardial activity related to myocardial blood flow during myocardial ischemia and pharmacologic coronary artery vasodilation, and shows little or no myocardial redistribution over 4 hr after intravenous injection. In six ...

The peripheral blood smears of 214 thermally injured patients studied during a thirty month period revealed a 20 percent incidence of normoblastemia (51 patients). Nucleated red blood cells were most common in patients with the largest burns. The absolute...

Resorption of N2 bubbles was measured in vitro in moving streams of saline, red cells suspended in saline, plasma, or whole blood. The absolute volume of the bubble was determined every 4 min by a compression technique. The diffusion characteristics are d...