Serial blood leucocyte counts were made on 35 ill preterm and term babies during the first 28 days of life. Ill babies with no clinical or bacteriological evidence of infection showed no changes in the blood leucocytes during the neonatal period when compared with normal babies. The changes in the blood leucocytes in babies with proven or suspected bacterial infection were an ...

A reliable and cost-effective laboratory method for diagnosing early bacterial infection is needed. The purpose of this study is to compare the sensitivity and specificity of the mean neutrophil volume (MNV) and neutrophil volume distribution width (NDW) parameters with manual band counts, as well as absolute ...

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The purpose was to determine the association of milk California Mastitis Test (CMT), somatic cell concentration (SCC), and milk differential cell count results on day 3 postcalving with subsequent lactation production and health events. On d 3 postcalving, the CMT was performed and quarter milk samples were collected from 130 dairy cows. Quarter SCC and milk differential cell ...

BackgroundLaboratory testing in clinical practice is never a random process. In this study we evaluated testing bias for neutrophil counts in clinical practice by using results from requested and non-requested hematological blood tests.MethodsThis study was conducted using data from the Utrecht Patient Oriented Database. This clinical database is unique, ...

The leukocyte count showed no remarkable changes. The number of neutral red vacuoles in the neutrophils was increased following x irradiation, while the number of mitochondria in lymphocytes was decreased and the neutral red vacuoles were increased. The refractiveness reached its maximum after 2 hr and returned to normal after 24 hr. Relative ...

We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil ...

Blood samples were obtained from 155 North American river otters (Lontra canadensis; 94 adult males, 38 adult females, 10 juvenile males, and 13 juvenile females) to establish baseline hematology and from 50 adult river otters (40 males and 10 females) for baseline serum biochemistry parameters for the species. The otters were livetrapped from eastern North Carolina (USA) during a 4-yr period. ...

Some studies have suggested that high levels of total white blood cell (WBC) count and C-reactive protein (CRP) may be considered as independent prognostic factors in patients with acute coronary syndromes (ACS) and/or after cardiac revascularisation by percutaneous coronary intervention or coronary artery bypass grafting surgery. Evidence on the role of ...

BackgroundInfections, particularly those caused by invasive fungi, are a major cause of death in patients with severe aplastic anemia. The purpose of this study was to analyze our experience with granulocyte transfusions in such patients.Design and MethodsA retrospective analysis was performed on all patients with severe aplastic anemia who had received granulocyte transfusions between 1997 and ...

High neutrophil counts in induced sputum have been found in nonasthmatic amateur runners at rest and after a marathon, but the pathogenesis of airway neutrophilia in athletes is still poorly understood. Bronchial epithelial damage may occur during intense exercise, as suggested by investigations conducted in endurance-trained mice and competitive human ...

Pegfilgrastim is a sustained-duration form of filgrastim, a recombinant methionyl form of human granulocyte colony-stimulating factor (G-CSF), to which a 20? kDa polyethylene glycol molecule is covalently bound to the N-terminal methionine residue. Similar to filgrastim, pegfilgrastim increases the proliferation and differentiation of neutrophils from committed progenitor ...

The leucocyte count and blood formula were determined at 3, 9, 16, 21, 30, 90, l80, 270, and 360 days after the irradiation of rats with a dose of 500 r. At 30 days the per cent and absolute number of segmented neutrophils was twice the initial level, and the per cent of lymphocytes was 68.3%, compared to 81.7% before ...

... Pagination or Media Count : 35. ... that PS+SAP inserts channels into artificial membranes, depolarizes neutrophils, decreases calcium influx following ...

Neutrophil recovery has been implicated in deterioration of oxygenation and exacerbation of lung injury in pediatric oncology patients. Our objectives were to determine the impact of neutrophil recovery on oxygenation in pediatric oncology patients with acute hypoxemic respiratory failure (AHRF) and to identify risk factors that result in oxygenation ...

BackgroundBenign neutropenia, i.e., neutropenia not associated with an increased risk of infection, may result in serious medical consequences when a 'standard' definition of neutropenia (absolute neutrophil count (ANC) < 1.5 � 10⁹cells/L) is universally applied to all races. The aims of this study were to ...

Cyclic Neutropenia (CN) is characterized by recurrent infections, fever, oral ulcerations, and severe periodontitis as result of the reduced host defences. The previous studies have established the effectiveness of recombinant granulocyte colony-stimulating factor (GCSF) to increase the number and the function of neutrophils in the peripheral blood in this disease. In a ...

... COUNTING METHODS, *TRITIUM, *HALF LIFE, HYDROGEN, GASES ... AND NUCLEAR CHEMISTRY ISOTOPES ATOMIC AND MOLECULAR ...

We have reported that lactoferrin, a 77-kDa iron-binding glycoprotein found in secondary neutrophil granules, provides a useful marker of fecal leukocytes in fecal specimens from patients with inflammatory diarrhea (R. L. Guerrant, V. Araujo, E. Soares, K. Kotloff, A. A. M. Lima, W. H. Cooper, and A. G. Lee, J. Clin. Microbiol. 30:1238-1242, 1992). In order to determine the ...

... with age. The lower your neutrophil count, the more vulnerable you are to infectious diseases. If you have severe neutropenia � fewer than about 500 cells per microliter of blood � bacteria normally present in your mouth and digestive tract can cause infections. Causes References ...

The rapid increase in the prevalence of antibiotic-resistant pathogens is a global problem that has challenged our ability to treat serious infections. Currently, clinical decisions on treatment are often based on in vitro susceptibility data. The role of the immune system in combating bacterial infections is unequivocal, but it is not well captured quantitatively. In this study, the impact of ...

This study was purposed to assess the efficacy of stanozolol for treatment of childhood patients with acquired non-severe aplastic anemia (NSAA). The records of 114 children with acquired NSAA treated in hospital between January 1996 and January 2009 were analyzed retrospectively. All patients received stanozolol with the dose of 0.1 mg/(kg�d). Some patients were treated with supportive care. ...

Abstract Background aims. Neutropenia following high-dose chemotherapy is associated with a substantial risk of infectious complications. The aim of this study was to identify variables in residual leukocyte subsets during neutropenia that are predictive for neutropenic fever. Methods. Residual leukocytes in the peripheral blood on day 5 after autologous blood stem cell transplantation were ...

In 2005, 224 patients received adjuvant/neoadjuvant chemotherapy for breast cancer in a single institution according to daily practices. Regimens consisted of epirubicin-based chemotherapy (FEC100, four or six cycles), or three cycles of FEC100 followed by three cycles of docetaxel. An absolute blood count was carried out every 3 weeks, 1�3 days before ...

To assess the effects of radiotherapy on immune status, a wide range of assessments have been performed on patients with localized carcinoma of the cervix uteri undergoing and initially responding clinically to radical pelvic radiotherapy. neutrophil function was essentially unchanged by treatment. Absolute neutrophil and lymphocyte ...

Experiments were carried out on peripheral blood leukocytes and spleen lymphocytes from 29 male rats that were flown during the Spacelab Life Sciences 1 (SLS-1) nine-day mission on the shuttle Columbia in June 1991 and on appropriate ground controls. On the day of landing, there was a significant decrease in the total white blood cell counts (P < 0.0001) of flight animals ...

Neutrophil counts in blood are determined by the differentiation and proliferation of precursor cells in the bone marrow, release of mature neutrophils into the blood, margination in organs like the lung and spleen, and transmigration through the endothelial lining followed by neutrophil apoptosis and uptake by ...

Cases with abnormal blood pictures due to radiation exposures were picked from the radiological workers at Tohoku University to determine characteristic blood pictures of occupational radiation hazards. The study was carried out on persons with less than 1500 lymphocytes and less than 5000 leukocytes for 2 successive examinations. Decreased total leukocyte and ...

BackgroundLimited erythropoietin (Epo) production diminishes neonates� ability to regenerate blood removed by phlebotomy. Neonates requiring surgery are at risk to receive multiple transfusions. We sought to determine if recombinant Epo administration to neonates requiring surgery would stimulate erythropoiesis.MethodsInfants were randomized in double-masked fashion to receive Epo (200 units ...

Severe congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute neutrophil count <0.5?�?10(9) /L and recurrent bacterial infections. Homozygous mutations of either HAX-1 or ELA-2 have been described. We report the case of a ...

Objective: To retrospectively examine rates of hematological adverse events (HAEs) in psychiatrically ill, hospitalized children treated with clozapine. Method: Clozapine treatment was administered in an open-label fashion using a flexible titration schedule, and data from weekly complete blood counts was obtained. The rate of neutropenia and agranulocytosis (HAEs) development ...

Serial leucocyte counts were done on 15 full-term babies during the first 10 days of life and on 14 prematures during the first 30 days. In addition a single count was done on the total of 53 babies around the 96th hour of life. Absolute values of each cell type are given for each postnatal age examined. The main changes in the ...

A comparative analysis was made of dynamics of recovery of peripheral blood neutrophils in the presence of acute radiation pathology in man and four species of laboratory animals. It was demonstrated that extent of abortive neutrophil elevation is related to radiation dosage and species of mammal. It was established that during the period of genuine ...

Ten individuals received an average of 0.211 roentgens of gamma radiation per week for a 77 period week (December 1946-June 1948) for a total average dose of 16.21 roentgens. During this period these 10 men carried out an experiment involving materials which emit gamma radiation and were monitored by daily film badges. The radiation delivered during a week was received in a five day work week and ...

A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute ...

The immature platelet fraction (IPF) as determined by the Sysmex XE-2100 is a rapid automated measure of the least mature component of the platelet population and is thought to correlate with thrombopoietic activity of the marrow. We investigated the ability of IPF to predict platelet recovery following hematopoietic progenitor cell (HPC) transplantation. IPF was compared to standard parameters of ...

Low circulating levels of high density lipoprotein cholesterol (HDL-C) are associated with increased risk for cardiovascular events. HDL-C has a variety of poorly understood atheroprotective effects, including altering lipid metabolism and reducing inflammation. Increased arterial stiffness is an important predictor of subsequent cardiovascular risk. Therefore, in the current study, we sought to ...

... Report Date : 23 AUG 1972. Pagination or Media Count : 28. Abstract : Absolute electron yields from tantalum, molybdenum, copper and aluminum ...

of decline and nadir of peripheral blood absolute lymphocyte depletion. The "normal" range for absolute lymphocyte count can vary, even in a healthy adult population. See graph...

A retrospective study was done on total white blood cell (WBC) and blood neutrophil counts of 41 mares referred to one of two veterinary hospitals for correction of dystocia. The mares were 2 to 19 years of age and included draft, light, and pony breeds. The WBC and neutrophil counts were performed at varying ...

The paper discusses the functional activity of peripheral neutrophilic granulocytes in 25 patients with autoimmune thyroiditis (AIT). The course of the latter is shown to be attended by a reduction in serum lactoferrin levels with simultaneous increases in the production of active oxygen forms and in the blood count of CD95+ granulocytes. PMID:17915484

The neutrophilic granulocyte count in the blood responds quickly to infection in dogs. The ratio of non-segmented to segmented neutrophils increased progressively after induction of bacterial pneumonia showing a rapid release from the bone marrow of less ...

BACKGROUND: High resolution computed tomography (HRCT) is now recognised as a sensitive tool for predicting the histological characteristics of the lung parenchymal abnormalities in patients with idiopathic pulmonary fibrosis (IPF). A reticular pattern on HRCT scanning is indicative of fibrotic histology while a ground glass pattern has been associated with inflammatory disease. The purpose of the ...

Bloodstream infection is an important cause of death among leukemia patients, and the etiologic agent surveillance is important for the prophylaxis and treatment. This study aims to identify the common bloodstream isolates in hospitalized leukemia patients with septicemia in our hospital, to choose the ideal combination of antimicrobial agents for infection prophylaxis and to clarify the ...

A group of 20 male rats of mean initial body weight of 65.53 g were irradiated for 7 weeks (5 d per week, 4 h per d) with an electromagnetic pulse field of the following parameters: working frequency 2736.5 MHz; repeated frequency 395 Hz; pulse width 2.6 musec; vertical polarization; mean power density 24.4 mW/cm2; accuracy of measuring +- 6%. The rectal temperature of experimental animals ...

Clozapine is an atypical antipsychotic agent used for refractory schizophrenia. It has a relatively low affinity for D2 receptors and thus is associated with a lower incidence of extrapyramidal side effects when compared with typical antipsychotics. Clozapine as monotherapy can induce a rare, but serious, blood dyscrasia called agranulocytosis; however, some concomitant medications may contribute ...

Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) that stimulates production of neutrophils. The objective of this analysis was to develop a pharmacokinetic (PK) and pharmacodynamic (PD) model to account for an increase in G-CSF clearance on multiple dosing because of an increase of the G-CSF receptor-mediated endocytosis. Data from 4 randomized ...

Adeno-associated virus (AAV) vectors have been shown to preferentially transduce hepatocytes after systemic administration in adult mice and to provide long-term expression of introduced genes. One application of this technology would be for the production of granulocyte colony-stimulating factor (G-CSF), which increases mature neutrophil numbers in humans and in animals, and ...

Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic differentiation which may respond to the administration of cytokines with increases in the number of circulating mature neutrophils. We used fluorescence in situ hybridization (FISH) to investigate a young patient with myelodyplasia associated with monosomy 7 to determine whether mature appearing ...

Unmanipulated HLA-haploidentical/mismatch related transplantation with combined granulocyte-colony stimulating factor-mobilized peripheral blood stem cells (G-PBSCs) and granulocyte-colony stimulating factor-mobilized bone marrow (G-BM) has been used as an alternative transplantation strategy for patients without an HLA-matched donor. In this transplantation setting, factors associated with ...

Purpose:To evaluate the association between systemic parameters including inflammatory markers and diabetic retinopathy (DR).Methods:Cross-sectional study of 30,793 people who visited a healthcare center for medical checkup. Diabetic patients were classified into five DR groups: no DR, mild, moderate, severe non-proliferative and proliferative DR. Full laboratory work-up and comprehensive medical ...

BackgroundHematological abnormalities are a common complication of HIV infection. These abnormalities increase as the disease advances. Bone marrow abnormalities occur in all stages of HIV infection.MethodsTwo hundred HIV infected individual were screened for hematological abnormalities from March 2007�March 2008. Absolute CD4 cell count analysis was ...

We examined the preliminary safety and efficacy of intravenous samarium-153-EDTMP (Sm-153) in the treatment of refractory rheumatoid arthritis (RA). In an open-label sequential group comparison of 0.5, 1.0, and 2.0 mCi/kg, Sm-153 was administered as a single intravenous infusion to 24 patients with refractory disease. Across treatment doses, the frequency of American College of Rheumatology (ACR) ...

Observations in a patient with recurrent hyperthyroidism, each time associated with neutropenia which resolved after therapy, prompted a chart review of other patients referred for radioactive iodine therapy. Of 99 untreated patients, 18 had neutrophil counts of less than 2,000/cu mm. After therapy with either thionamides or /sup 131/I, 41 of 53 (77%) ...

A 10-year-old girl with steroid-resistant Diamond-Blackfan anemia (DBA) developed agranulocytosis 9 weeks after chelation with deferiprone was initiated (45 mg/kg daily, 60% of recommended dose) in addition to her ordinary deferoxamine therapy. The blood counts, checked weekly, dropped markedly between weeks 8 and 9. She rapidly developed a septicemia and was admitted with ...

... disease severity. In Study 012, the success rates based on EGSS and mean absolute change in lesion count were marginally higher in the ...

... Report Date : SEP 1965. Pagination or Media Count : 31. Descriptors : *MANOMETERS, HEAT TRANSFER, TRANSPIRATION, FLOW FIELDS. ...

... Pagination or Media Count : 58. Abstract : Diabetes mellitus is a chronic and incurable disorder involving a relative or absolute lack of insulin. ...

... decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics ...

... source in water and in two aluminum and water mixtures. ... By use of experimentally determined counting efficiencies, absolute saturation activities ...

... the hand. The puncture site is cleaned with antiseptic, and an elastic band is placed around the ... or young child, the area is cleansed with antiseptic and punctured with a sharp needle or a ...

Absolute and relative detector efficiencies measured. Apparatus uses coincidence-counting techniques

... Pagination or Media Count : 20. Abstract : The shrinkage of resin and thermal expansion during the curing of epoxy (epon 826) were measured. ...

Differential blood count. Lymphocytes, percent. Neutrophiles, percent. Band cells, percent. Monocytes, percent. Eosineophiles, percent. Basophiles, percent ...

Aim: Pharmacological profiling techniques, such as the cantharidin-induced skin blister, may be used to assess the anti-inflammatory properties of novel drugs. However, no data are available on the reproducibility of this technique or on the blocking effect of anti-inflammatory drugs, such as anti-TNF and corticosteroids. Methods: A group of 30 healthy subjects were randomized into 3 parallel ...

Background A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. DESIGN AND METHODS: Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compared to ...

Abstract Objectives: Fetal neutrophilia is present in two-thirds of cases with the fetal inflammatory response syndrome (FIRS). The mechanisms responsible for this finding have not been elucidated. Granulocyte colony-stimulating factor (G-CSF) is the primary physiologic regulator of neutrophil production and plays a key role in the rapid generation and release of ...

Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies. We reviewed the Microbiology Laboratory records dated from July 1, 2000, to June 30, 2002, to identify patients who had respiratory specimens positive for influenza, parainfluenza, ...

CS-0777 is a selective sphingosine 1-phosphate receptor-1 (S1P(1)) modulator under development for treatment of autoimmune conditions. A randomized, double-blind, placebo-controlled study was conducted to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CS-0777 in escalating dose cohorts of healthy male participants (0.1, 0.3, 1.0, and 2.5 mg; 6 ...

A patient with chronic myelocytic leukemia had a cyclic oscillation of blood neutrophils, eosinophils, basophils, monocytes, platelets, normoblasts, and reticulocytes but not of lymphocytes. The cycle interval was 53-69 days. Except for reticulocytes all other cells cycled with neutrophils. Plasma colony-stimulating factor (CSF) oscillated out of phase ...

Healthy African Americans are known to have reduced white blood cell counts (WBC) and absolute neutrophil counts (ANC) compared with European Americans, with little agreement about the levels in reference intervals. The objective is to establish race-specific reference intervals for WBC and ANC using US National ...

Aims: To investigate the acute systemic inflammatory response to welding fume exposure. Methods: Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM_2.5) was assessed using cyclone samplers. Markers of systemic inflammation, including C-reactive protein (CRP), fibrinogen, and ...

The presence of alpha-defensins in bronchoalveolar lavage fluid (BALF) was investigated in a cohort of preterm newborns with gestational age (GA) < or =30 wk. Specimens were collected during the first week of life from 24 preterm neonates mechanically ventilated. The studied population was divided into two groups: pneumonia group of nine neonates suffering from pulmonary infection (GA: 26.1 +/- ...

1. Background: Bone marrow engraftment is mediated by stem cells with complex self-renewal, proliferative and differentiation potentials. This process is empirically documented by the progressive rise in the absolute neutrophil count occurring 2 to 3 weeks post-marrow infusion. 2. Purpose: To investigate the kinetics of early ...

A high count rate 4 pi beta - gamma coincidence counting system for the determination of absolute disintegration rates of short half-life radionuclides is described. With this system the dead time per pulse is minimized by not stretching any pulses beyond...

This study evaluated the phagocytic and bactericidal activities of peripheral blood leukocytes from Hiroshima and Nagasaki atomic bomb survivors for Staphylococcus aureus. The data were analyzed by multiple linear regression for age, sex, radiation exposure, city of exposure, and neutrophil counts. No significant radiation effect was observed for either ...

ObjectiveTo assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE).MethodsIn an open label, dose-escalating, Phase I study, 16 patients with mild to moderate disease activity were treated bi-weekly for 12 weeks with one of three doses (2 mg/kg [n=4], 4 mg/kg ...

Tumor necrosis factor (TNF) plays an important role in the inflammatory process of RA and the resulting joint pathology. Etanercept is a member of anti TNF family which is indicated in patients with moderate to severe active rheumatoid arthritis either alone or in combination with MTX. Very few cases of neutropenia with etanercept treatment have been reported worldwide so far. The mechanism of ...

The optimal dosing schedule of G-CSF for peripheral blood progenitor cell (PBPC) mobilization is still under investigation although many centers use 10 microg/kg/day in a single subcutaneous dose. However, G-CSF clearance increases with increasing absolute neutrophil count (ANC). Hence a G-CSF dosage adjusted to ANC might be a ...

BACKGROUND: Monotherapy has tended to replace the combination therapy in emprical treatment of febrile neutropenia. There is no reported trial which compares the efficacy of cefoperazone-sulbactam (CS) and piperacillin-tazobactam (PIP/TAZO) monotherapies in the treatment of febrile neutropenia. In this prospective randomized study, we aimed to compare the safety and efficacy of CS versus PIP/TAZO ...

To test the supposition that during the day changes occurred in the blood picture of people subject to occupational radiation exposures, workers with marked decreases of leukocyte counts and workers who had recovered from the effects of excessive radiation were selected for study from radiological employees and x-ray techniciane. In the cases of long-standing service ...

We examined the relationship of leukocyte colony-stimulating activity (CSA) in vitro to neutrophil count in vivo. Using a standard two-layer system, cultures of 10⁶ leukocytes were assayed for their ability to stimulate colony formation by human bone marrow colony-forming cells. The total leukocyte CSA per ml (TLCSA) of blood varied ...

Fanconi anemia (FA) is a genetically very heterogeneous disease making routine detection of carriers quite difficult by molecular analysis. Finding alternative method has vital importance especially in populations where prevalence of the disease is quite high because of consanguineous marriages. The aim of this study was to find a considerably reliable parameter to detect FA carriers by methods ...

BackgroundMalaria is the commonest cause of childhood morbidity in Western Kenya with varied heamatological consequences. The t study sought to elucidate the haemotological changes in children infected with malaria and their impact on improved diagnosis and therapy of childhood malaria.MethodsHaematological parameters in 961 children, including 523 malaria-infected and 438 non-malaria infected, ...

Neutrophils are required for the development of arthritis in rodents, and are the predominant cell in the synovial fluid of active rheumatoid arthritis. We hypothesized that neutrophil migration into the inflammed joint is genetically regulated. In addition, this genetic regulation would be accounted for by one of the arthritis loci that we have previously ...

This work describes recent results from our research program aiming at the synthesis and evaluation of new compounds acting as potential anti-inflammatory drugs. A series of novel acyl-hydrazones bearing 2-aryl-thiazole moiety were synthesized by the condensation between derivatives of 4-[2-(4-methyl-2-phenyl-thiazole-5-yl)-2-oxo-ethoxy]-benzaldehyde and 2, 3 or ...

Genetic deficiency of adenosine deaminase (ADA) can cause profound lymphopenia and result in the clinical presentation of severe combined immune deficiency (SCID). However, due to the ubiquitous expression of ADA, ADA-deficient patients often present also with non-immunological clinical problems, affecting the skeletal, central nervous, endocrine and gastrointestinal systems. We now report that ...

The patient is a 44-year-old woman with metastatic grade 3 intra-ductal carcinoma of the breast who was started on palliative chemotherapy (docetaxel) 10 days prior to admission and presented to the emergency center complaining of diffuse abdominal pain and generalized weakness. CT abdomen showed diffuse bowel wall thickening from the cecum to the transverse colon with free fluid in the pelvis. ...

The aim of this study was to investigate the effects of human tryptases on inflammatory cell accumulation in vivo. Various concentrations of purified lung or skin tryptases were injected into the peritoneum of BALB/c mouse. At 6 hours or 16 hours following injection, cells from the peritoneal lavage were collected and stained with modified Wright's stain. Differential cell ...

To determine the role of polymorphonuclear (PMN) leukocyte transfusions in neonates with sepsis, 23 consecutive newborns were prospectively randomly selected during an 18-month period in a treatment plan to receive polymorphonuclear leukocyte transfusions with supportive care or supportive care alone. Thirteen neonates received transfusions every 12 hours for a total of five transfusions. Each ...

Immature reticulocyte fraction a new routine parameter in the hematology analyzer can give the idea of the earliest morphologic change of bone marrow recovery before other test become positive after chemotherapy. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration with Paediatric Haematology and Oncology, Bangabandhu Sheikh Mujib Medical ...

In the present study we examined the presence of Hepatitis C virus (HCV) RNA sequences in eosinophils (Eos) isolated from 10 chronically HCV-infected patients. At the time of the study patients showed levels of alanine aminotransferase (ALT) and aspartate aminotranferase (AST) above the normal upper limits (129 IU/L +/- 77 and 56.2 IU/L +/- 40, respectively). Absolute and ...

The report describes a subacute syndrome consisting of anorexia, mouth ulcers, abdominal pain, and diarrhea which occurred in three allogenic transplant recipients which appears to be distinct from the usual patterns of acute or chronic graft-versus-host disease (GVHD). The patient with myelomonocytic leukemia was treated with cyclophosphamide (60 mg/kg) i.v. 4 and 3 days before and total body X ...

Rabbit anti-cat neutrophil serum was injected intraperitoneally into cats to study its effects on blood neutrophil numbers, on development of neutrophils in bone marrow, and on the fate of circulating and developing neutrophils. There was a significant difference (P less than 0.05) in curves of blood ...

BACKGROUND:: Parainfluenza virus (PIV) infections are an important cause of morbidity in children with upper or lower respiratory tract infection (URTI and LRTI, respectively). However, the epidemiology of PIV infections in children with cancer has not been well studied. METHODS:: This retrospective study sought to determine the epidemiology of PIV infections and risk factors for progression to an ...

More than 2 million Americans use cocaine each month (National Survey on Drug Use and Health, Department of Health and Human Services: Substance Abuse and Mental Health Services Administration (SAMHSA) & Office of Applied Studies (OAS), Rockville, MD 2007). Starting in early 2003, South American cocaine cartels began to add levamisole, a pharmaceutical agent, to bulk cocaine prior to shipment ...

efficiency of photon-counting detectors without reference to any externally calibrated detector standard [3 variation of the absolute response of a photon counting system can be measured at a range of wavelengthsmetrologia Absolute detector quantum-efficiency measurements using correlated photons A. L. Migdall

We have previously demonstrated that 5-aza-2'-deoxycytidine (decitabine) augments fetal hemoglobin (HbF) levels in patients with sickle cell anemia (SS) who did not respond to hydroxyurea (HU). The present study was designed to determine the effect of repeated decitabine dosing on HbF levels and hematologic toxicity over a 9-month treatment period. Seven patients (5 HU nonresponders) were entered. ...

BackgroundSuppression of immune system in treated cancer patients may lead to secondary infections that obviate the need of antibiotics. In the present study, an attempt was made to understand the occurrence of secondary infections in immuno-suppressed patients along with herbal control of these infections with the following objectives to: (a) isolate the microbial species from the treated oral ...

Interleukin (IL)�6 concentrations are positively associated with the severity of pneumonia, and this cytokine is essential to surviving experimental pneumococcal pneumonia. The role that IL-6 plays during pneumonia and its impact during gram-negative bacterial pneumonia remain to be determined. During Escherichia coli pneumonia, IL-6�deficient mice had increased bacterial burdens in their ...

A method for absolute calibration of proportional counters for pulsed fast neutrons is presented. The method is based on the use of an isotopic standard source and development of a model for counting detected events from area of a signal compounded by single piled up neutron pulses. Effects of detection counting statistics and ...

A method for absolute calibration of proportional counters for pulsed fast neutrons is presented. The method is based on the use of an isotopic standard source and development of a model for counting detected events from area of a signal compounded by single piled up neutron pulses. Effects of detection counting statistics and ...

This report presents the results of a measurement of the half-life of tritium by absolute counting. The method consisted in the mass-spectrometric analysis of a hydrogen-tritium mixture enriched in tritium, the dilution of some of this material with hydrogen in a known way to a countable level of activity, and the counting of a portion ...

The correlation counting method is extended to two-step cascade processes with relatively long-lived intermediate states. Expressions are given for the statistical uncertainties and deadtime effects. The technique is applied to the absolute standardisation of 75Se, 67Ga, 67Cu and 85Sr activities, and to the detection and estimation of afterpulses in liquid ...

The ability of neutron probes to provide accurate and reproducible soil moisture measurements is discussed. It is stressed that sensitivity of the probe in terms of soil moisture measurements is of greater interest than efficiency in terms of absolute counts or counting rate per millicurie. The importance of calibration curve ...

AIM/BACKGROUND: Previous studies have suggested that healthy subjects of African ancestry have lower total white cell counts, neutrophil counts and platelet counts than Caucasian subjects and that, at least among Caucasians, women have higher neutrophil and platelet counts ...

Changes in peripheral blood cell levels were followed in rats exposed to x-ray doses of 600 r, some of which were pre-treated with 10 mg of this compound, previously shown to be radioprotective in mice. This dose proved absolutely lethal for the unprotected animals, which died between the 10th and 24th day, but 80% of the treated animals survived to at least the 30th ...

Our previous studies revealed that intravaginal infection of mice with a plasmid-deficient strain of C. muridarum, CM3.1, does not induce the development of oviduct pathology. In this study we determined that infection with CM3.1 resulted in a significantly reduced frequency and absolute number of neutrophils in the oviducts during acute infection. This ...

It has been reported that the stimulation of neutrophils with N-formyl-Met-Leu-Phe (fMLF), an agonist for formyl peptide receptor (Fpr) 1, renders cells unresponsive to other chemoattractants in vitro. This is known as cross-desensitization, but its functional relevance in neutrophil migration in vivo has not been investigated. Here, we show that precedent ...

Sep 18, 2007 ... The unmodeled variance in the background rate, which fundamentally ... Faint Sources (Absolute Flux Measurements) - For absolute X-ray flux .... for dead time using the excess count rate above the background level; ...

We report on progress made mapping Aristarchus Crater using high-resolution LROC NAC images. Observations include enigmatic impact melt features and stratified blocks of ejecta. An absolute model age using crater counts was also determined.

ObjectivesThe objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer.DesignThis study is a pilot, randomized, sham-controlled clinical trial. Patients ...

F344/N rats and B6C3F1 mice were exposed to 0, 1, 3, or 6 ppm methyl isocyanate by inhalation for 6 hr on 4 consecutive days. Deaths of rats were observed following 3 ppm exposures, and mice died after exposures to 6 ppm. Deaths appeared to be related to severe respiratory distress. Survivors in high dose groups lost weight initially, then gained weight at rates equal to controls throughout a ...

To clarify whether measurement of serum haptoglobin (Hp) has impact on understanding pathophysiology in bone marrow failure (BMF) syndromes, we investigated concentrations of serum Hp by nephelometric procedure in 156 Japanese patients with BMF, including 54 aplastic anemia (AA), 50 paroxysmal nocturnal hemoglobinuria (PNH), and 52 myelodysplastic syndromes (MDS) patients. The frequencies with low ...

In the present study, we explored the involvement of interleukin-6 (IL-6) in neutrophilia under inflammatory conditions. The neutrophil count in the peripheral blood was high in arthritic monkeys, and anti-IL-6 receptor antibody reduced neutrophil counts to normal levels. IL-6 injection into normal monkeys ...

Background and purpose:? Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been identified as a severe complication of patients previously treated with intravenous bisphosphonates. It has been noted that necrotic bone from BRONJ sites display signs of bacterial infection suggesting that an immune defect may play a role in the pathophysiology of BRONJ. The purpose of this study was to ...

PURPOSEFebrile neutropenia commonly complicates cancer chemotherapy. Outpatient treatment may reduce costs and improve patient comfort but risk progression of undetected medical problems. PATIENTS AND METHODSBy using our validated algorithm, we identified medically stable inpatients admitted for febrile neutropenia (neutrophils < 500/?L) after chemotherapy and randomly ...

... data and absolute bird counts. This will entail learning R (programming language) and using methods such as zero-inflated poisson ... ...

... Pagination or Media Count : 14. Abstract : We present a method for estimating the absolute frequency stability of N clocks separate from a reference. ...

Methodology is presented for conducting drive-line counts to obtain absolute numbers of deer within fairly small (

... specimen controls (individuals with known chromosome number). For chromosome counts, floral buds or root tips were fixed in Carnoy's solution (absolute ethanol ... ...

... RESEARCH DEPT. Personal Author(s) : Cope,Freeman W. Report Date : 21 MAY 1968. Pagination or Media Count : 13. Abstract ...

The average values and the range of drumstick counts in the neutrophil granuiocytes in males and females of a normal group of rhesus monkeys were estimated. No important individual differences in counting were found between two groups of workers. Irradiation and treatment with autologous bone marrow does not influence the ...

REPORT Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume Manuel A region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs provided estimates for neutrophil (NEUT), monocyte (MONO), eosinophil (EOS), basophil (BASO

A survey was made of hemoglobin and white cell count levels based on the data from hematological investigations made on new employees between the years 1949 and 1960. The data were analyzed according to age, sex, and season of the year and the results were compared with those of other workers. It is suggested that the normal range for neutrophil ...

A whole-blood method was used for measuring neutrophil migration in micropore membrane. The method is reproducible (coefficient of variation (CV) 10.3% and 9.8% in two normal individuals tested repeatedly) and can be performed on an 0.25 ml lithium heparin blood sample. Migration is independent of leucocyte and erythrocyte counts and is comparable with ...

Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross: Silica, inflammation and thrombosis Descriptor number: 116, 120. Word count: 3,752. AJRCCM Articles inflammation induced by silica for the development of peripheral thrombogenicity in a hamster model

Background and ObjectivesAspiration thrombectomy (AT) during primary percutaneous coronary intervention (PCI) is an effective adjunctive therapy for ST-segment elevation myocardial infarction (STEMI). An elevated neutrophil count in STEMI is associated with microvascular dysfunction and adverse outcomes. We evaluated whether AT can improve microvascular ...

Interactions were studied between human neutrophils and cultured human umbilical vein endothelial cells invaded by Candida albicans. In the absence of neutrophils, progressive Candida germination and hyphal growth extensively damaged endothelial cell monolayers over a period of 4 to 6 hours, as determined both by morphological changes and release of /sup ...

Tumor infiltrate, predominantly constituted by lymphocytes, may represent an important prognostic factor in bronchioloalveolar carcinoma (BAC), in addition to tumor extension and histological type. In the present study, we determined the presence, the origin, and the prognostic importance of neutrophils that also participate in leukocyte infiltrates of BAC. ...

... poisoning. ^ Back to top 2. What are other names for neutrophils that might appear on a lab ... form. Thank you. * indicates a required field First Name: Last Name: Please indicate whether you are a: ...

Exact Match  Begins With  Contains Name/Code  Property  Relationship Home | View Hierarchy | Subsets | Help Visited Concepts EVS Home NCI Metathesaurus Browser NCI Term Browser NCI Terminology Resources Term Suggestion Neutrophil Band Form Count (Code

Exact Match� Begins With� Contains Name/Code� Property� Relationship Home | View Hierarchy | Subsets | Help Visited Concepts EVS Home NCI Metathesaurus Browser NCI Term Browser NCI Terminology Resources Term Suggestion Vacuolated Neutrophil Count (Code

The establishment of the dependence of changes in the hemostatis system of the body under the effect of low barometric pressure on the neutrophil leukocytes count and the functional state of their lysosomal apparatus involved experiments on 60 rabbits of ...

Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied. In each case the pharmacokinetic profile suggested saturable elimination kinetics, and the temporal relation of mianserin concentrations and the neutrophil count suggested a direct toxic effect of mianserin on the bone marrow. Until further studies ...

Pasteurella haemolytica is an important respiratory pathogen of cattle that incites extensive infiltrates of neutrophils into the lung. In addition to the parenchymal damage caused by factors released by P. haemolytica, neutrophils contribute to the pathologic changes in the lungs. Molecules which mediate neutrophil infiltration into ...

OBJECTIVEInflammatory markers such as C-reactive protein (CRP) are related to obesity in adults, but the association is less clear in children. Our objective was to examine relationships between multiple markers of inflammation and children�s weight status; we hypothesized that the prevalence of inflammatory markers would increase as weight status increased.METHODSWe conducted a cross-sectional ...

Periodontal disease is defined as inflammation that is caused by bacteria in dental plaque. This disease is liable to be a factor contributing to the high leukocyte count over an extended period. Furthermore, a number of prospective epidemiologic studies have shown that the leukocyte count is a good predictor of ischemic heart disease (IHD). However there ...

Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once-weekly doses of 25 to 50 mg of rifalazil were well tolerated. In this ...

BACKGROUND: About 25% of greenhouse flower and/or ornamental plant growers sensitised to workplace flowers or moulds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops. Aim: To document a case of occupational asthma due to IgE mediated allergy to the flower Molucella laevis. METHODS: and Results: There was a history of work related seasonal ...

Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC ...

Eighteen patients with Fanconi anemia (FA) with evidence of bone marrow (BM) aplasia underwent allogenic BM transplants (BMT) from matched sibling donors (MSD). Median age at BMT was 7.6 years. Conditioning consisted of low-dose cyclophosphamide (CY; 5 mg/kg x 4 days) and thoracoabdominal irradiation (TAI; 400 cGy). Graft-versus-host disease (GVHD) prophylaxis included cyclosporin A and ...

BackgroundThe CALGB evaluated oral topotecan administered at two schedules and doses for MDS.MethodsPatients with previously untreated primary or therapy-related MDS were eligible. Patients with refractory anemia (RA), RA with ringed sideroblasts (RARS), or refractory cytopenia with multilineage dysplasia (RCMD) were eligible only if red cell transfusion dependent, platelet ...

PURPOSE: Intraperitoneal chemotherapy has shown a survival advantage over intravenous chemotherapy for women with newly diagnosed optimally debulked epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. However, significant toxicity has limited its acceptance. In an effort to reduce toxicity, the Gynecologic Oncology Group conducted a Phase I study to evaluate the feasibility of day ...

Ramzi M, Zakerinia M, Nourani H, Dehghani M, Vojdani R, Haghighinejad H. Non-cryopreserved hematopoietic stem cell transplantation in multiple myeloma, a single center experience. Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01432.x. � 2011 John Wiley & Sons A/S. Abstract:? Several clinical trials have shown the superiority of high-dose therapy (HDT) and autologous stem cell ...

Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC ...

Nineteen patients with Fanconi anemia (FA) and bone marrow failure underwent bone marrow transplantation (BMT) from matched siblings. Median age at BMT was 8.7 years. Conditioning consisted of low-dose cyclophosphamide (CY 5 mg/kg x 4 days) and thoracoabdominal irradiation (TAI 400 cGy). Graft-versus-host disease (GVHD) prophylaxis was cyclosporin A (CsA) in 13 patients and CsA plus methotrexate ...

Differential white blood cell count (dWBC) is a frequently used diagnostic tool. For most patient samples an automated blood counter produces a five-part differential count. If this dWBC does not meet pre-set criteria, microscopic dWBC is performed. Microscopy is labor intensive and requires sustained training of technicians. Inter-observer variation and ...

Objective To develop a novel prognostic indicator for use in patients with advanced cancer that is significantly better than clinicians� estimates of survival.Design Prospective multicentre observational cohort study.Setting 18 palliative care services in the UK (including hospices, hospital support teams, and community teams).Participants 1018 patients with locally advanced or metastatic ...

A method is described for measuring the absolute disintegration rate of 87.2-day sulfur-35. ( beta -E/sub max/ = 0.167 Mev). The sulfur to be assayed is converted to sulfur dioxide by ignition of barium sulfate with red phosphorus in an atmosphere of oxygen. The sulfur dioxide is then mixed with methane and counted in an internal gas ...

The design and construction of 4 pi Geiger Mueller Counters, and the technique of absolute radioactivity measurements by beta-particle counting are discussed. Three sources of error are considered: The probability of obtaining one count for each beta-particle passing into the counter volume; Losses due to the absorption of ...

A two-stage absolute counting facility for large liquid samples of aqueous Mn/sup 56/SO/sub 4/, primarily intended for better than 1% precision measurements of neutron source strengths by the manganese bath technique, is described. Two-liter samples are counted in a gamma - gamma coincidence arrangement that greatly improves ...

We have constructed a yeast (Saccharomyces cerevisiae) particle capable of releasing NO, by loading heat-killed yeast particles with a hydrophobic NO-generating substance, GEA-5171. This particle decreased phagocytosis in solution, as measured with flow cytometry, to about 80% of control values. Phagocytosis on a surface, as counted under the microscope, was also decreased by ...

Sickle cell anemia is associated with susceptibility to infection due to hyposplenism and the reduced ability of neutrophils to kill pathogenic organisms. In this study, blood samples from sickle cell anemia patients were divided into two groups: the painful crisis group and the steady state group. Flow cytometric assessment of phagocytosis and burst formation of ...

Background The well-characterised airway inflammatory phenotypes of asthma include eosinophilic, neutrophilic, mixed eosinophilic/neutrophilic and paucigranulocytic asthma, identified based on the proportion of sputum granulocytes. Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic ...

A procedure is presented for the conversion of rough results (cpm) obtained in liquid scintillation counting into absolute values (dpm). From the investigation of ten identical samples it has been shown that the samples statistically differ from each other when rough results are taken into consideration but with the obtained ...

The fast neutron fission cross section of exp 233 U was measured absolutely between 0.13 and 8.0 MeV. The absolute cross section values were obtained by low geometry alpha counting and isotopic dilution analysis of various exp 233 U samples, 2 pi -detecti...

An absolute measurement of exp 238 U capture rate was made on FCA Assembly V-2, a physics mock-up of JOYO. The method is that exp 239 Np activities were counted with a Ge(Li) detector which had been absolutely calibrated by using exp 238 U foils irradiate...

A method previously developed by Zumwalt for the determination in an absolute form of the decay rate of beta emitting nuclides is presented from the viewpoint of measurement conditions. A study was made of all the factors which arise in the measurement of the absolute activity using a Geiger counter. The correction factors for emissions whose ...

Earlier studies demonstrated that dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation attenuates the chemotactic response of neutrophils and the generation of leukotriene (LT) B4 by neutrophils stimulated with calcium ionophore; however, the mechanisms and relationship of these effects were not examined. Neutrophils and ...

Hypertonic saline (HS) resuscitation after hemorrhage and sepsis has been shown to markedly reduce the development of lung injury in animals, compared with traditional resuscitation with lactated Ringer's (LR). These experiments examined the effect of HS on lung injury after hemorrhage without sepsis. The effects of HS and LR resuscitation on neutrophil trafficking, ...

Thesis. One of the most essential devices for the absolute counting of alpha -particles emitted by alpha-active substances is the low geometry counter. In this device, the alpha -particles emitted by the sample pass the collimator apenture and are counted by an appropriate detector, with the sample and collimator being ...

White cell counts at rest might be lower in athletes participating in selected endurance-type sports. Here, we analysed blood tests of elite athletes collected over a 10-year period. Reference ranges were established for 14 female and 14 male sports involving 3,679 samples from 937 females and 4,654 samples from 1,310 males. Total white blood cell counts ...

Determination of the proportion of neutrophils in the peripheral blood is important for diagnostic purposes in medicine and for evaluating new drugs in the pharmaceutical industry. To measure the neutrophil concentration in rat blood, a fast and accurate flow cytometric method was developed. Rat neutrophils were quantified by using ...

Data were compiled from clinical materials, including 87 cases with malignant neoplasms subjected to radiation therapy. The tables presented in this article show that there is a change in the number of leukocytes in the peripheral blood under the effect of ionizing radiation in the majority of patients, (the presence of leukopenia with regrouping of the neutrophils ...

The majority of practical radioactive materials decay by modes that include {gamma}-ray emission. For questions of 'how much' or 'how pure', one must know the absolute intensities of the major radiations. We are using liquid scintillation counting (LSC) to measurements of disintegration rates, coupled with {gamma}-ray ...

The precision and accuracy of the Hemalog D, which uses cytochemical identification of cells in suspension, and of the Hematrak, which uses image recognition of cells on a stained blood film, have been compared counting normal blood samples. The Hemalog D showed superior precision for all cell types, as would be expected since 10,000 cells are counted per ...

Propylthiouracil and methimazole are used widely in the treatment of hyperthyroid disorders. The most important complication of the use of these drugs is depression of the neutrophilic granulocyte count. Granulocytopenia occurs in about 4 percent and agranulocytosis occurs in about 0.3 percent of treated patients. Although this depression of the ...

The absolute CD19+ lymphocytes count is essential for chronic lymphocytic leukemia (CLL) management. At the present time, no standardized flow cytometry (FCM) protocol to measure B-lymphocytes counts is established. The aims of the present study were first to evaluate the effect of different lysis solutions and of red blood cell lysis ...

BackgroundPrevious studies have reported that the adoption of a single-platform flow cytometry cell counting method resulted in lower interlaboratory variation in absolute T cell counts as compared to predicate dual-platform flow cytometry methods which incorporate independent automated lymphocyte counts ...

A new radioisotopic technique has been developed for quantification of deposition of neutrophilic granulocytes on vascular grafts. Nine healthy mongrel dogs underwent bilateral femoral artery resection and reconstruction with grafts of the femoral vein and Gore-Tex. Pure granulocytes that had been separated from whole blood by centrifugal elutriation were labeled with /sup ...

We studied whether ozone-induced hyperresponsiveness could be inhibited by neutrophil depletion in dogs. Responsiveness was assessed with dose-response curves of acetylcholine aerosol versus pulmonary resistance; depletion was assessed by counting neutrophils in venous blood and in biopsies of the airway epithelium. Responsiveness and ...

�Neutropenia� refers to deficient numbers of neutrophils, the most abundant type of white blood cell. Two main forms of inherited neutropenia are cyclic neutropenia, in which neutrophil counts oscillate with a 21-day frequency, and severe congenital neutropenia, in which static neutropenia may evolve at times into leukemia. ...

The authors examined several sources of error in isotopic flux measurements in a commonly used experimental model: the study of {sup 22}Na and {sup 36}Cl fluxes across rat ileal tissue mounted in the Ussing flux chamber. The experiment revealed three important sources of error: the absolute counts per minute, the difference in counts ...

The peripheral blood of x-ray workers was examined by using supravital staining. The number of neutralred vacuoles and degenerated forms of neutrophils was increased. In the lymphocytes the average number of mitochondria was decreased, and neutral-red vacuoles and refractive neutral-red vacuoles were increased in number. In the blood picture there was slight ...

Despite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. For years, investigators have sought a test or panel of tests able to identify septic neonates accurately and rapidly in order to obtain an early diagnosis and develop a specific effective treatment for a successful outcome. In ...

BackgroundAplastic anemia (AA) is a serious and rare disorder characterized by a hypocellular bone marrow. Hepatitis associated aplastic anemia (HAAA) is a variant of aplastic anemia in which aplastic anemia follows an acute attack of hepatitis. Several reports have noted an association between HGV and hepatitis-associated aplastic anemia besides other hepatitis causing viruses.Case presentationA ...

BACKGROUNDSamarium-153 ethylenediaminetetramethylene phosphonic acid (¹⁵³Sm-EDTMP) has been used to treat patients with high-risk osteosarcoma. The purpose of the current study was to determine the maximally tolerated dose of ¹⁵³Sm-EDTMP that permits hematopoietic recovery within 6 weeks.METHODSPatients with recurrent or refractory osteosarcoma with ...

Purpose: To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10 and 20 Gy or more (PBM-V{sub 10} and PBM-V{sub 20}) is associated with acute hematologic toxicity (HT) in anal cancer patients treated with concurrent chemoradiotherapy. Methods and Materials: We analyzed 48 consecutive anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiation ...

BACKGROUND /AIMS: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-? (pegIFN)-related thrombocytopenia, neutropenia and leukopenia. METHODS: 1604/3070 patients in the IDEAL study consented to genetic testing. Trial inclusion ...