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Sample records for absolute source activity

  1. Active radiometric calorimeter for absolute calibration of radioactive sources

    NASA Astrophysics Data System (ADS)

    Stump, K. E.; DeWerd, L. A.; Rudman, D. A.; Schima, S. A.

    2005-03-01

    This report describes the design and initial noise floor measurements of a radiometric calorimeter designed to measure therapeutic medical radioactive sources. The instrument demonstrates a noise floor of approximately 2 nW. This low noise floor is achieved by using high temperature superconducting (HTS) transition edge sensor (TES) thermometers in a temperature-control feedback loop. This feedback loop will be used to provide absolute source calibrations based upon the electrical substitution method. Other unique features of the calorimeter are (a) its ability to change sources for calibration without disrupting the vacuum of the instrument, and (b) the ability to measure the emitted power of a source in addition to the total contained source power.

  2. Metallic Magnetic Calorimeters for Absolute Activity Measurement

    NASA Astrophysics Data System (ADS)

    Loidl, M.; Leblanc, E.; Rodrigues, M.; Bouchard, J.; Censier, B.; Branger, T.; Lacour, D.

    2008-05-01

    We present a prototype of metallic magnetic calorimeters that we are developing for absolute activity measurements of low energy emitting radionuclides. We give a detailed description of the realization of the prototype, containing an 55Fe source inside the detector absorber. We present the analysis of first data taken with this detector and compare the result of activity measurement with liquid scintillation counting. We also propose some ways for reducing the uncertainty on the activity determination with this new technique.

  3. Absolute enantioselective separation: optical activity ex machina.

    PubMed

    Bielski, Roman; Tencer, Michal

    2005-11-01

    The paper describes methodology of using three independent macroscopic factors affecting molecular orientation to accomplish separation of a racemic mixture without the presence of any other chiral compounds, i. e., absolute enantioselective separation (AES) which is an extension of a concept of applying these factors to absolute asymmetric synthesis. The three factors may be applied simultaneously or, if their effects can be retained, consecutively. The resulting three mutually orthogonal or near orthogonal directors constitute a true chiral influence and their scalar triple product is the measure of the chirality of the system. AES can be executed in a chromatography-like microfluidic process in the presence of an electric field. It may be carried out on a chemically modified flat surface, a monolithic polymer column made of a mesoporous material, each having imparted directional properties. Separation parameters were estimated for these media and possible implications for the natural homochirality are discussed. PMID:16342798

  4. Testing the quasi-absolute method in photon activation analysis

    SciTech Connect

    Sun, Z. J.; Wells, D.; Starovoitova, V.; Segebade, C.

    2013-04-19

    In photon activation analysis (PAA), relative methods are widely used because of their accuracy and precision. Absolute methods, which are conducted without any assistance from calibration materials, are seldom applied for the difficulty in obtaining photon flux in measurements. This research is an attempt to perform a new absolute approach in PAA - quasi-absolute method - by retrieving photon flux in the sample through Monte Carlo simulation. With simulated photon flux and database of experimental cross sections, it is possible to calculate the concentration of target elements in the sample directly. The QA/QC procedures to solidify the research are discussed in detail. Our results show that the accuracy of the method for certain elements is close to a useful level in practice. Furthermore, the future results from the quasi-absolute method can also serve as a validation technique for experimental data on cross sections. The quasi-absolute method looks promising.

  5. On the Error Sources in Absolute Individual Antenna Calibrations

    NASA Astrophysics Data System (ADS)

    Aerts, Wim; Baire, Quentin; Bilich, Andria; Bruyninx, Carine; Legrand, Juliette

    2013-04-01

    The two main methods for antenna calibration currently in use, are anechoic chamber measurements on the one hand and outdoor robot calibration on the other hand. Both techniques differ completely in approach, setup and data processing. Consequently, the error sources for both techniques are totally different as well. Except for the (near field) multi path error, caused by the antenna positioning device, that alters results for both calibration methods. But not necessarily with the same order of magnitude. Literature states a (maximum deviation) repeatability for robot calibration of choke ring antennas of 0.5 mm on L1 and 1 mm on L2 [1]. For anechoic chamber calibration, a value of 1.5 mm on L2 for a resistive ground plane antenna can be found in [2]. Repeatability however masks systematic errors linked with the calibration technique. Hence, comparing an individual calibration obtained with a robot to a calibration of the same antenna in an anechoic chamber, may result in differences that surpass these repeatability thresholds. This was the case at least for all six choke ring antennas studied. The order of magnitude of the differences moreover corresponded well to the values given for a LEIAT504GG in [3]. For some error sources, such as the GNSS receiver measurement noise or the VNA measurement noise, estimates can be obtained from manufacturer specifications in data sheets. For other error sources, such as the finite distance between transmit and receive antenna, or the limited attenuation of reflections on wall absorber, back-of-the-envelope calculations can be made to estimate their order of magnitude. For the error due to (near field) multi path this is harder to do, if not impossible. The more because this strongly depends on the antenna type and its mount. Unfortunately it is, again, this (near field) multi path influence that might void the calibration once the antenna is installed at the station. Hence it can be concluded that at present, due to (near

  6. Metrological activity determination of 133Ba by sum-peak absolute method

    NASA Astrophysics Data System (ADS)

    da Silva, R. L.; de Almeida, M. C. M.; Delgado, J. U.; Poledna, R.; Santos, A.; de Veras, E. V.; Rangel, J.; Trindade, O. L.

    2016-07-01

    The National Laboratory for Metrology of Ionizing Radiation provides gamma sources of radionuclide and standardized in activity with reduced uncertainties. Relative methods require standards to determine the sample activity while the absolute methods, as sum-peak, not. The activity is obtained directly with good accuracy and low uncertainties. 133Ba is used in research laboratories and on calibration of detectors for analysis in different work areas. Classical absolute methods don't calibrate 133Ba due to its complex decay scheme. The sum-peak method using gamma spectrometry with germanium detector standardizes 133Ba samples. Uncertainties lower than 1% to activity results were obtained.

  7. Neutron activation analysis of certified samples by the absolute method

    NASA Astrophysics Data System (ADS)

    Kadem, F.; Belouadah, N.; Idiri, Z.

    2015-07-01

    The nuclear reactions analysis technique is mainly based on the relative method or the use of activation cross sections. In order to validate nuclear data for the calculated cross section evaluated from systematic studies, we used the neutron activation analysis technique (NAA) to determine the various constituent concentrations of certified samples for animal blood, milk and hay. In this analysis, the absolute method is used. The neutron activation technique involves irradiating the sample and subsequently performing a measurement of the activity of the sample. The fundamental equation of the activation connects several physical parameters including the cross section that is essential for the quantitative determination of the different elements composing the sample without resorting to the use of standard sample. Called the absolute method, it allows a measurement as accurate as the relative method. The results obtained by the absolute method showed that the values are as precise as the relative method requiring the use of standard sample for each element to be quantified.

  8. Diagnostic Application of Absolute Neutron Activation Analysis in Hematology

    SciTech Connect

    Zamboni, C.B.; Oliveira, L.C.; Dalaqua, L. Jr.

    2004-10-03

    The Absolute Neutron Activation Analysis (ANAA) technique was used to determine element concentrations of Cl and Na in blood of healthy group (male and female blood donators), select from Blood Banks at Sao Paulo city, to provide information which can help in diagnosis of patients. This study permitted to perform a discussion about the advantages and limitations of using this nuclear methodology in hematological examinations.

  9. Absolute configuration and antimicrobial activity of acylhomoserine lactones.

    PubMed

    Pomini, Armando M; Marsaioli, Anita J

    2008-06-01

    (S)-N-Heptanoylhomoserine lactone is an uncommon acyl odd-chain natural product employed by many Gram-negative bacteria as a signaling substance in chemical communication mechanisms known as quorum sensing. The absolute configuration determination of the metabolite produced by the phytopathogen Pantoea ananatis Serrano is reported herein. As with all other substances of this class, the lactone moiety possesses S configuration, corroborating the hypothesis that it shares the same biosynthetic pathway as the (S)-N-hexanoylhomoserine lactone and also that some LuxI homologues can accept both hexanoyl- and heptanoyl-ACP as precursors. Evaluation of the antimicrobial activity of enantiomeric acylhomoserine lactones against three Gram-positive bacteria (Bacillus cereus, B. subtilis, and Staphylococcus aureus) revealed important features between absolute configuration and antimicrobial activity. The N-heptanoylhomoserine lactone was considerably less active than the 3-oxo derivatives. Surprisingly, non-natural (R)-N-(3-oxo-octanoyl)homoserine lactone was as active as the S enantiomer against B. cereus, while the synthetic racemic product was less active than either enantiomer. PMID:18465897

  10. Development of an absolute method for efficiency calibration of a coaxial HPGe detector for large volume sources

    NASA Astrophysics Data System (ADS)

    Ortiz-Ramírez, Pablo C.

    2015-09-01

    In this work an absolute method for the determination of the full energy peak efficiency of a gamma spectroscopy system for voluminous sources is presented. The method was tested for a high-resolution coaxial HPGe detector and cylindrical homogeneous volume source. The volume source is represented by a set of point sources filling its volume. We found that the absolute efficiency of a volume source can be determined as the average over its volume of the absolute efficiency of each point source. Experimentally, we measure the intrinsic efficiency as a function upon source-detector position. Then, considering the solid angle and the attenuations of the gamma rays emitted to the detector by each point source, considered as embedded in the source matrix, the absolute efficiency for each point source inside of the volume was determined. The factor associate with the solid angle and the self-attenuation of photons in the sample was deduced from first principles without any mathematical approximation. The method was tested by determining the specific activity of 137Cs in cylindrical homogeneous sources, using IAEA reference materials with specific activities between 14.2 Bq/kg and 9640 Bq/kg at the moment of the experimentation. The results obtained shown a good agreement with the expected values. The relative difference was less than 7% in most of the cases. The main advantage of this method is that it does not require of the use of expensive and hard to produce standard materials. In addition it does not require of matrix effect corrections, which are the main cause of error in this type of measurements, and it is easy to implement in any nuclear physics laboratory.

  11. Absolute flux density calibrations of radio sources: 2.3 GHz

    NASA Technical Reports Server (NTRS)

    Freiley, A. J.; Batelaan, P. D.; Bathker, D. A.

    1977-01-01

    A detailed description of a NASA/JPL Deep Space Network program to improve S-band gain calibrations of large aperture antennas is reported. The program is considered unique in at least three ways; first, absolute gain calibrations of high quality suppressed-sidelobe dual mode horns first provide a high accuracy foundation to the foundation to the program. Second, a very careful transfer calibration technique using an artificial far-field coherent-wave source was used to accurately obtain the gain of one large (26 m) aperture. Third, using the calibrated large aperture directly, the absolute flux density of five selected galactic and extragalactic natural radio sources was determined with an absolute accuracy better than 2 percent, now quoted at the familiar 1 sigma confidence level. The follow-on considerations to apply these results to an operational network of ground antennas are discussed. It is concluded that absolute gain accuracies within + or - 0.30 to 0.40 db are possible, depending primarily on the repeatability (scatter) in the field data from Deep Space Network user stations.

  12. Absolute determination of the neutron source yield using melamine as a neutron detector

    NASA Astrophysics Data System (ADS)

    Ciechanowski, M.; Bolewski, A., Jr.; Kreft, A.

    2015-01-01

    A new approach to absolute determination of the neutron source yield is presented. It bases on the application of melamine (C3H6N6) to neutron detection combined with Monte Carlo simulations of neutron transport. Melamine has the ability to detect neutrons via 14N(n, p)14C reaction and subsequent determination of 14C content. A cross section for this reaction is relatively high for thermal neutrons (1.827 b) and much lower for fast neutrons. A concentration of 14C nuclei created in the irradiated sample of melamine can be reliably measured with the aid of the accelerator mass spectrometry (AMS). The mass of melamine sufficient for this analysis is only 10 mg. Neutron detection is supported by Monte Carlo simulations of neutron transport carried out with the use of MCNP-4C code. These simulations are aimed at computing the probability of 14C creation in the melamine sample per the source neutron. The result of AMS measurements together with results of MCNP calculations enable us to determine the number of neutrons emitted from the source during the irradiation of melamine. The proposed method was applied for determining the neutron emission from a commercial 252Cf neutron source which was independently calibrated. The measured neutron emission agreed with the certified one within uncertainty limits. The relative expanded uncertainty (k=2) of the absolute neutron source yield determination was estimated at 2.6%. Apart from calibration of radionuclide neutron sources the proposed procedure could facilitate absolute yield measurements for more complex sources. Potential applications of this methodology as it is further developed include diagnostics of inertial confinement fusion and plasma-focus experiments, calibration of neutron measurement systems at tokamaks and accelerator-based neutron sources as well as characterization of neutron fields generated in large particle detectors during collisions of hadron beams.

  13. Absolute pulse energy measurements of soft x-rays at the Linac Coherent Light Source.

    PubMed

    Tiedtke, K; Sorokin, A A; Jastrow, U; Juranić, P; Kreis, S; Gerken, N; Richter, M; Arp, U; Feng, Y; Nordlund, D; Soufli, R; Fernández-Perea, M; Juha, L; Heimann, P; Nagler, B; Lee, H J; Mack, S; Cammarata, M; Krupin, O; Messerschmidt, M; Holmes, M; Rowen, M; Schlotter, W; Moeller, S; Turner, J J

    2014-09-01

    This paper reports novel measurements of x-ray optical radiation on an absolute scale from the intense and ultra-short radiation generated in the soft x-ray regime of a free electron laser. We give a brief description of the detection principle for radiation measurements which was specifically adapted for this photon energy range. We present data characterizing the soft x-ray instrument at the Linac Coherent Light Source (LCLS) with respect to the radiant power output and transmission by using an absolute detector temporarily placed at the downstream end of the instrument. This provides an estimation of the reflectivity of all x-ray optical elements in the beamline and provides the absolute photon number per bandwidth per pulse. This parameter is important for many experiments that need to understand the trade-offs between high energy resolution and high flux, such as experiments focused on studying materials via resonant processes. Furthermore, the results are compared with the LCLS diagnostic gas detectors to test the limits of linearity, and observations are reported on radiation contamination from spontaneous undulator radiation and higher harmonic content. PMID:25321502

  14. Potential Skin Regeneration Activity and Chemical Composition of Absolute from Pueraria thunbergiana Flower.

    PubMed

    Kim, Do-Yoon; Won, Kyung-Jong; Hwang, Dae-Il; Yoon, Seok Won; Lee, Su Jin; Park, Joo-Hoon; Yoon, Myeong Sik; Kim, Bokyung; Lee, Hwan Myung

    2015-11-01

    The flower of Pueraria thunbergiana BENTH (PTBF) contains isoflavonoids and essential oil components. It has many biological and pharmacological activities, including anti-diabetes, anti-oxidant, and weight loss. However, its effect on skin regeneration remains unknown. In the present study, we isolated the absolute from PTBF through solvent extraction and determined the role of the absolute on skin regeneration-associated responses in human epidermal-keratinocytes (HaCats). The PTBF absolute, which contained 10 compounds, stimulated migration and proliferation and increased the phosphorylation of serine/threonine-specific protein kinase and extracellular signal-regulated kinasel/2 in HaCats. It induced type I and IV collagen synthesis in HaCats. In addition, treatment with PTBF absolute resulted in increased sprout outgrowth in HaCats. These findings suggest that PTBF absolute may participate in skin regeneration, probably through promotion of migration, proliferation, and collagen synthesis. PMID:26749850

  15. Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration.

    PubMed

    Awale, Suresh; Kato, Mamoru; Dibwe, Dya Fita; Li, Feng; Miyoshi, Chika; Esumi, Hiroyasu; Kadota, Shigetoshi; Tezuka, Yasuhiro

    2014-01-01

    From a MeOH extract of powdered roots of Wikstroemia indica, six dibenzyl-gamma-butyrolactone-type lignans with (2S,3S)-absolute configuration [(+)-arctigenin (1), (+)-matairesinol (2), (+)-trachelogenin (3), (+)-nortrachelogenin (4), (+)-hinokinin (5), and (+)-kusunokinin (6)] were isolated, whereas three dibenzyl-gamma-butyrolactone-type lignans with (2R,3R)-absolute configuration [(-)-arctigenin (1*), (-)-matairesinol (2*), (-)-trachelogenin (3*)] were isolated from Trachelospermum asiaticum. The in vitro preferential cytotoxic activity of the nine compounds was evaluated against human pancreatic PANC-1 cancer cells in nutrient-deprived medium (NDM), but none of the six lignans (1-6) with (2S,3S)-absolute configuration showed preferential cytotoxicity. On the other hand, three lignans (1*-3*) with (2R,3R)-absolute configuration exhibited preferential cytotoxicity in a concentration-dependent manner with PC50 values of 0.54, 6.82, and 5.85 microM, respectively. Furthermore, the effect of (-)- and (+)-arctigenin was evaluated against the activation of Akt, which is a key process in the tolerance to nutrition starvation. Interestingly, only (-)-arctigenin (1*) strongly suppressed the activation of Akt. These results indicate that the (2R,3R)-absolute configuration of (-)-enantiomers should be required for the preferential cytotoxicity through the inhibition of Akt activation. PMID:24660468

  16. Mosher Amides: Determining the Absolute Stereochemistry of Optically-Active Amines

    ERIC Educational Resources Information Center

    Allen, Damian A.; Tomaso, Anthony E., Jr.; Priest, Owen P.; Hindson, David F.; Hurlburt, Jamie L.

    2008-01-01

    The use of chiral reagents for the derivatization of optically-active amines and alcohols for the purpose of determining their enantiomeric purity or absolute configuration is a tool used by many chemists. Among the techniques used, Mosher's amide and Mosher's ester analyses are among the most reliable and one of the most often used. Despite this,…

  17. Absolute and relative emission spectroscopy study of 3 cm wide planar radio frequency atmospheric pressure bio-plasma source

    NASA Astrophysics Data System (ADS)

    Deng, Xiaolong; Nikiforov, Anton Yu; Ionita, Eusebiu-Rosini; Dinescu, Gheorghe; Leys, Christophe

    2015-08-01

    The dynamics of low power atmospheric pressure radio frequency discharge generated in Ar gas in long gap of 3 cm is investigated. This plasma source is characterized and analyzed for possible large scale biomedical applications where low gas temperature and potential-less effluent are required. The discharge forms a homogenous glow-like afterglow in ambient air at input power of 30 W with low gas temperature of 330 K, which is desirable in biomedical applications. With absolute calibrated spectroscopy of the discharge, electron density of 0.4 × 1018 m-3 and electron temperature of 1.5 eV are obtained from continuum Bremsstrahlung radiation of the source. Time and spatial resolved emission spectroscopy is used to analyze discharge generation mechanism and active species formation. It is found that discharge dynamics strongly correlates with the discharge current waveform. Strong Ar(2p) excited states emission is observed nearby the electrodes surface on a distance up to 200 μm in the plasma sheath region at 10 ns after the current peak, whereas OH(A) emission is uniform along of the interelectrode gap.

  18. Chemical composition, olfactory evaluation and antimicrobial activity of selected essential oils and absolutes from Morocco.

    PubMed

    Wanner, Juergen; Schmidt, Erich; Bail, Stefanie; Jirovetz, Leopold; Buchbauer, Gerhard; Gochev, Velizar; Girova, Tanya; Atanasova, Teodora; Stoyanova, Albena

    2010-09-01

    The chemical compositions of selected essential oils from North Africa, especially Morocco, of geranium, wild Moroccan chamomile and rosemary as well as absolutes of rose and geranium were determined using GC/FID and GC/MS. These oils and absolutes were tested concerning their antimicrobial activity against some food spoilage strains obtained from fresh milk and minced meat products, like sausages and pork fillet, in accordance with ISO testing procedures. Gram-positive (Bacillus cereus and Staphylococcus aureus) and Gram-negative (Escherichia coli, Salmonella abony and Pseudomonas aeruginosa) strains were used, as well as the yeast Candida albicans. Using a serial broth dilution method, all samples demonstrated weak antimicrobial activity against the Gram-negative bacteria and the yeast, compared with the activity towards the Gram-positive bacteria. PMID:20922989

  19. Absolute configuration of a new mosquito repellent, (+)-eucamalol and the repellent activity of its epimer.

    PubMed

    Satoh, A; Utamura, H; Nakade, T; Nishimura, H

    1995-06-01

    (+)-Eucamalol (1) and (-)-1-epi-eucamalol (2) were synthesized from (S)-(-)-perillaldehyde to determine the absolute configuration of 1, the structure of natural (+)-eucamalol being determined to be (1R,6R)-(+)-3-formyl-6-isopropyl-2-cyclohexen-1-ol. (+)-Eucamolol (1) and its 1-epimer (2) exhibited significant repellent activity against Aedes albopictus, and inhibited its feeding as well as DEET. PMID:7613002

  20. Inversion of Multi-Station Schumann Resonance Background Records for Global Lightning Activity in Absolute Units

    NASA Astrophysics Data System (ADS)

    Williams, E. R.; Mushtak, V. C.; Guha, A.; Boldi, R. A.; Bor, J.; Nagy, T.; Satori, G.; Sinha, A. K.; Rawat, R.; Hobara, Y.; Sato, M.; Takahashi, Y.; Price, C. G.; Neska, M.; Alexander, K.; Yampolski, Y.; Moore, R. C.; Mitchell, M. F.; Fraser-Smith, A. C.

    2014-12-01

    Every lightning flash contributes energy to the TEM mode of the natural global waveguide that contains the Earth's Schumann resonances. The modest attenuation at ELF (0.1 dB/Mm) allows for the continuous monitoring of the global lightning with a small number of receiving stations worldwide. In this study, nine ELF receiving sites (in Antarctica (3 sites), Hungary, India, Japan, Poland, Spitsbergen and USA) are used to provide power spectra at 12-minute intervals in two absolutely calibrated magnetic fields and occasionally, one electric field, with up to five resonance modes each. The observables are the extracted modal parameters (peak intensity, peak frequency and Q-factor) for each spectrum. The unknown quantities are the geographical locations of three continental lightning 'chimneys' and their lightning source strengths in absolute units (C2 km2/sec). The unknowns are calculated from the observables by the iterative inversion of an evolving 'sensitivity matrix' whose elements are the partial derivatives of each observable for all receiving sites with respect to each unknown quantity. The propagation model includes the important day-night asymmetry of the natural waveguide. To overcome the problem of multiple minima (common in inversion problems of this kind), location information from the World Wide Lightning Location Network has been used to make initial guess solutions based on centroids of stroke locations in each chimney. Results for five consecutive days in 2009 (Jan 7-11) show UT variations with the African chimney dominating on four of five days, and America dominating on the fifth day. The amplitude variations in absolute source strength exceed that of the 'Carnegie curve' of the DC global circuit by roughly twofold. Day-to-day variations in chimney source strength are of the order of tens of percent. Examination of forward calculations performed with the global inversion solution often show good agreement with the observed diurnal variations at

  1. Source apportionment of gaseous atmospheric pollutants by means of an absolute principal component scores (APCS) receptor model.

    PubMed

    Bruno, P; Caselli, M; de Gennaro, G; Traini, A

    2001-12-01

    A multivariate statistical method has been applied to apportion the atmospheric pollutant concentrations measured by automatic gas analyzers placed on a mobile laboratory for air quality monitoring in Taranto (Italy). In particular, Principal Component Analysis (PCA) followed by Absolute Principal Component Scores (APCS) technique was performed to identify the number of emission sources and their contribution to measured concentrations of CO, NOx, benzene toluene m+p-Xylene (BTX). This procedure singled out two different sources that explain about 85% of collected data variance. PMID:11798109

  2. Easy Absolute Values? Absolutely

    ERIC Educational Resources Information Center

    Taylor, Sharon E.; Mittag, Kathleen Cage

    2015-01-01

    The authors teach a problem-solving course for preservice middle-grades education majors that includes concepts dealing with absolute-value computations, equations, and inequalities. Many of these students like mathematics and plan to teach it, so they are adept at symbolic manipulations. Getting them to think differently about a concept that they…

  3. The absolute CBF response to activation is preserved during elevated perfusion: Implications for neurovascular coupling measures

    PubMed Central

    Whittaker, Joseph R.; Driver, Ian D.; Bright, Molly G.; Murphy, Kevin

    2016-01-01

    Functional magnetic resonance imaging (fMRI) techniques in which the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) response to a neural stimulus are measured, can be used to estimate the fractional increase in the cerebral metabolic rate of oxygen consumption (CMRO2) that accompanies evoked neural activity. A measure of neurovascular coupling is obtained from the ratio of fractional CBF and CMRO2 responses, defined as n, with the implicit assumption that relative rather than absolute changes in CBF and CMRO2 adequately characterise the flow-metabolism response to neural activity. The coupling parameter n is important in terms of its effect on the BOLD response, and as potential insight into the flow-metabolism relationship in both normal and pathological brain function. In 10 healthy human subjects, BOLD and CBF responses were measured to test the effect of baseline perfusion (modulated by a hypercapnia challenge) on the coupling parameter n during graded visual stimulation. A dual-echo pulsed arterial spin labelling (PASL) sequence provided absolute quantification of CBF in baseline and active states as well as relative BOLD signal changes, which were used to estimate CMRO2 responses to the graded visual stimulus. The absolute CBF response to the visual stimuli were constant across different baseline CBF levels, meaning the fractional CBF responses were reduced at the hyperperfused baseline state. For the graded visual stimuli, values of n were significantly reduced during hypercapnia induced hyperperfusion. Assuming the evoked neural responses to the visual stimuli are the same for both baseline CBF states, this result has implications for fMRI studies that aim to measure neurovascular coupling using relative changes in CBF. The coupling parameter n is sensitive to baseline CBF, which would confound its interpretation in fMRI studies where there may be significant differences in baseline perfusion between groups. The absolute change in

  4. Structure, absolute configuration, and antidiarrheal activity of a thymol derivative from Ageratina cylindrica.

    PubMed

    Bustos-Brito, Celia; Sánchez-Castellanos, Mariano; Esquivel, Baldomero; Calderón, José S; Calzada, Fernando; Yepez-Mulia, Lilian; Hernández-Barragán, Angelina; Joseph-Nathan, Pedro; Cuevas, Gabriel; Quijano, Leovigildo

    2014-02-28

    The leaves of Ageratina cylindrica afforded a thymol derivative that was characterized by physical and spectroscopical methods as (8S)-8,9-epoxy-6-hydroxy-l0-benzoyloxy-7-oxothymol isobutyrate (1). The absolute configuration of 1 was established as 8S by vibrational circular dichroism spectroscopy in combination with density functional theory calculations and by evaluation of the Flack and Hooft X-ray parameters. Compound 1 showed weak antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites and a high inhibitory effect on hyperpropulsive movement of the small intestine in rats. PMID:24502360

  5. Nitrogen-containing bibenzyls from Pleione bulbocodioides: absolute configurations and biological activities.

    PubMed

    Li, Yuan; Zhang, Fan; Wu, Ze-Hong; Zeng, Ke-Wu; Zhang, Chen; Jin, Hong-Wei; Zhao, Ming-Bo; Jiang, Yong; Li, Jun; Tu, Peng-Fei

    2015-04-01

    Four new pyrrolidone substituted bibenzyls, dusuanlansins A-D (1-4) were isolated from the pseudo bulbs of Pleione bulbocodioides, along with 19 known compounds (5-23). Compounds 1-4 are two pairs of epimers of pyrrolidone substituted bibenzyls, which were separated successfully by a Chiralcel OD-RH C18 column. Their absolute configurations were elucidated by calculated ECD. Biological investigations showed that compounds 5 and 7 exhibited potent anti-inflammatory activities on LPS-stimulated NO production in BV-2 microglial cells, with IC50 values of 2.46 and 3.14μM, respectively. PMID:25647325

  6. A comparison of absolute calibrations of a radiation thermometer based on a monochromator and a tunable source

    NASA Astrophysics Data System (ADS)

    Keawprasert, T.; Anhalt, K.; Taubert, D. R.; Sperling, A.; Schuster, M.; Nevas, S.

    2013-09-01

    An LP3 radiation thermometer was absolutely calibrated at a newly developed monochromator-based set-up and the TUneable Lasers in Photometry (TULIP) facility of PTB in the wavelength range from 400 nm to 1100 nm. At both facilities, the spectral radiation of the respective sources irradiates an integrating sphere, thus generating uniform radiance across its precision aperture. The spectral irradiance of the integrating sphere is determined via an effective area of a precision aperture and a Si trap detector, traceable to the primary cryogenic radiometer of PTB. Due to the limited output power from the monochromator, the absolute calibration was performed with the measurement uncertainty of 0.17 % (k = 1), while the respective uncertainty at the TULIP facility is 0.14 %. Calibration results obtained by the two facilities were compared in terms of spectral radiance responsivity, effective wavelength and integral responsivity. It was found that the measurement results in integral responsivity at the both facilities are in agreement within the expanded uncertainty (k = 2). To verify the calibration accuracy, the absolutely calibrated radiation thermometer was used to measure the thermodynamic freezing temperatures of the PTB gold fixed-point blackbody.

  7. A comparison of absolute calibrations of a radiation thermometer based on a monochromator and a tunable source

    SciTech Connect

    Keawprasert, T.; Anhalt, K.; Taubert, D. R.; Sperling, A.; Schuster, M.; Nevas, S.

    2013-09-11

    An LP3 radiation thermometer was absolutely calibrated at a newly developed monochromator-based set-up and the TUneable Lasers in Photometry (TULIP) facility of PTB in the wavelength range from 400 nm to 1100 nm. At both facilities, the spectral radiation of the respective sources irradiates an integrating sphere, thus generating uniform radiance across its precision aperture. The spectral irradiance of the integrating sphere is determined via an effective area of a precision aperture and a Si trap detector, traceable to the primary cryogenic radiometer of PTB. Due to the limited output power from the monochromator, the absolute calibration was performed with the measurement uncertainty of 0.17 % (k= 1), while the respective uncertainty at the TULIP facility is 0.14 %. Calibration results obtained by the two facilities were compared in terms of spectral radiance responsivity, effective wavelength and integral responsivity. It was found that the measurement results in integral responsivity at the both facilities are in agreement within the expanded uncertainty (k= 2). To verify the calibration accuracy, the absolutely calibrated radiation thermometer was used to measure the thermodynamic freezing temperatures of the PTB gold fixed-point blackbody.

  8. Correction to Method of Establishing the Absolute Radiometric Accuracy of Remote Sensing Systems While On-orbit Using Characterized Stellar Sources

    NASA Technical Reports Server (NTRS)

    Bowen, Howard S.; Cunningham, Douglas M.

    2007-01-01

    The contents include: 1) Brief history of related events; 2) Overview of original method used to establish absolute radiometric accuracy of remote sensing instruments using stellar sources; and 3) Considerations to improve the stellar calibration approach.

  9. Responses of absolute and specific soil enzyme activities to long term additions of organic and mineral fertilizer.

    PubMed

    Zhang, Xinyu; Dong, Wenyi; Dai, Xiaoqin; Schaeffer, Sean; Yang, Fengting; Radosevich, Mark; Xu, Lili; Liu, Xiyu; Sun, Xiaomin

    2015-12-01

    Long-term phosphorus (P) and nitrogen (N) applications may seriously affect soil microbial activity. A long-term field fertilizer application trial was established on reddish paddy soils in the subtropical region of southern China in 1998. We assessed the effects of swine manure and seven different rates or ratios of NPK fertilizer treatments on (1) the absolute and specific enzyme activities per unit of soil organic carbon (SOC) or microbial biomass carbon (MBC) involved in C, N, and P transformations and (2) their relationships with soil environmental factors and soil microbial community structures. The results showed that manure applications led to increases in the absolute and specific activities of soil β-1,4-glucosidase(βG), β-1,4-N-acetylglucosaminidase (NAG), and leucine aminopeptidase (LAP). The absolute and specific acid phosphatase (AP) activities decreased as mineral P fertilizer application rates and ratios increased. Redundancy analysis (RDA) showed that there were negative correlations between absolute and specific AP activities, pH, and total P contents, while there were positive correlations between soil absolute and specific βG, NAG, and LAP enzyme activities, and SOC and total N contents. RDA showed that the contents of actinomycete and Gram-positive bacterium PLFA biomarkers are more closely related to the absolute and specific enzyme activities than the other PLFA biomarkers (P<0.01). Our results suggest that both the absolute and specific enzyme activities could be used as sensitive soil quality indicators that provide useful linkages with the microbial community structures and environmental factors. To maintain microbial activity and to minimize environmental impacts, P should be applied as a combination of inorganic and organic forms, and total P fertilizer application rates to subtropical paddy soils should not exceed 44 kg P ha(-1) year(-1). PMID:26196069

  10. Absolute depth-dose-rate measurements for an {sup 192}Ir HDR brachytherapy source in water using MOSFET detectors

    SciTech Connect

    Zilio, Valery Olivier; Joneja, Om Parkash; Popowski, Youri; Rosenfeld, Anatoly; Chawla, Rakesh

    2006-06-15

    Reported MOSFET measurements concern mostly external radiotherapy and in vivo dosimetry. In this paper, we apply the technique for absolute dosimetry in the context of HDR brachytherapy using an {sup 192}Ir source. Measured radial dose rate distributions in water for different planes perpendicular to the source axis are presented and special attention is paid to the calibration of the R and K type detectors, and to the determination of appropriate correction factors for the sensitivity variation with the increase of the threshold voltage and the energy dependence. The experimental results are compared with Monte Carlo simulated dose rate distributions. The experimental results show a good agreement with the Monte Carlo simulations: the discrepancy between experimental and Monte Carlo results being within 5% for 82% of the points and within 10% for 95% of the points. Moreover, all points except two are found to lie within the experimental uncertainties, confirming thereby the quality of the results obtained.

  11. Absolute calibration method for laser megajoule neutron yield measurement by activation diagnostics.

    PubMed

    Landoas, Olivier; Glebov, Vladimir Yu; Rossé, Bertrand; Briat, Michelle; Disdier, Laurent; Sangster, Thomas C; Duffy, Tim; Marmouget, Jean Gabriel; Varignon, Cyril; Ledoux, Xavier; Caillaud, Tony; Thfoin, Isabelle; Bourgade, Jean-Luc

    2011-07-01

    The laser megajoule (LMJ) and the National Ignition Facility (NIF) plan to demonstrate thermonuclear ignition using inertial confinement fusion (ICF). The neutron yield is one of the most important parameters to characterize ICF experiment performance. For decades, the activation diagnostic was chosen as a reference at ICF facilities and is now planned to be the first nuclear diagnostic on LMJ, measuring both 2.45 MeV and 14.1 MeV neutron yields. Challenges for the activation diagnostic development are absolute calibration, accuracy, range requirement, and harsh environment. At this time, copper and zirconium material are identified for 14.1 MeV neutron yield measurement and indium material for 2.45 MeV neutrons. A series of calibrations were performed at Commissariat à l'Energie Atomique (CEA) on a Van de Graff facility to determine activation diagnostics efficiencies and to compare them with results from calculations. The CEA copper activation diagnostic was tested on the OMEGA facility during DT implosion. Experiments showed that CEA and Laboratory for Laser Energetics (LLE) diagnostics agree to better than 1% on the neutron yield measurement, with an independent calibration for each system. Also, experimental sensitivities are in good agreement with simulations and allow us to scale activation diagnostics for the LMJ measurement range. PMID:21806179

  12. Absolute nuclear material assay

    DOEpatents

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2012-05-15

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  13. Absolute nuclear material assay

    DOEpatents

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2010-07-13

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  14. Absolute height measurement of specular surfaces with modified active fringe reflection photogrammetry

    NASA Astrophysics Data System (ADS)

    Ren, Hongyu; Jiang, Xiangqian; Gao, Feng; Zhang, Zonghua

    2014-07-01

    Deflectometric methods have been studied for more than a decade for slope measurement of specular freeform surfaces through utilization of the deformation of a sample pattern after reflection from a tested sample surface. Usually, these approaches require two-directional fringe patterns to be projected on a LCD screen or ground glass and require slope integration, which leads to some complexity for the whole measuring process. This paper proposes a new mathematical measurement model for measuring topography information of freeform specular surfaces, which integrates a virtual reference specular surface into the method of active fringe reflection photogrammetry and presents a straight-forward relation between height of the tested surface and phase signals. This method only requires one direction of horizontal or vertical sinusoidal fringe patterns to be projected from a LCD screen, resulting in a significant reduction in capture time over established methods. Assuming the whole system has been precalibrated during the measurement process, the fringe patterns are captured separately via the virtual reference and detected freeform surfaces by a CCD camera. The reference phase can be solved according to the spatial geometric relation between the LCD screen and the CCD camera. The captured phases can be unwrapped with a heterodyne technique and optimum frequency selection method. Based on this calculated unwrapped-phase and that proposed mathematical model, absolute height of the inspected surface can be computed. Simulated and experimental results show that this methodology can conveniently calculate topography information for freeform and structured specular surfaces without integration and reconstruction processes.

  15. Muscle Activation During Exercise in Severe Acute Hypoxia: Role of Absolute and Relative Intensity

    PubMed Central

    Torres-Peralta, Rafael; Losa-Reyna, José; González-Izal, Miriam; Perez-Suarez, Ismael; Calle-Herrero, Jaime; Izquierdo, Mikel

    2014-01-01

    Abstract Torres-Peralta, Rafael, José Losa-Reyna, Miriam González-Izal, Ismael Perez-Suarez, Jaime Calle-Herrero, Mikel Izquierdo, and José A.L. Calbet. Muscle activation during exercise in severe acute hypoxia: Role of absolute and relative intensity. High Alt Med Biol 15:472–482, 2014.—The aim of this study was to determine the influence of severe acute hypoxia on muscle activation during whole body dynamic exercise. Eleven young men performed four incremental cycle ergometer tests to exhaustion breathing normoxic (FIo2=0.21, two tests) or hypoxic gas (FIo2=0.108, two tests). Surface electromyography (EMG) activities of rectus femoris (RF), vastus medialis (VL), vastus lateralis (VL), and biceps femoris (BF) were recorded. The two normoxic and the two hypoxic tests were averaged to reduce EMG variability. Peak Vo2 was 34% lower in hypoxia than in normoxia (p<0.05). The EMG root mean square (RMS) increased with exercise intensity in all muscles (p<0.05), with greater effect in hypoxia than in normoxia in the RF and VM (p<0.05), and a similar trend in VL (p=0.10). At the same relative intensity, the RMS was greater in normoxia than in hypoxia in RF, VL, and BF (p<0.05), with a similar trend in VM (p=0.08). Median frequency increased with exercise intensity (p<0.05), and was higher in hypoxia than in normoxia in VL (p<0.05). Muscle contraction burst duration increased with exercise intensity in VM and VL (p<0.05), without clear effects of FIo2. No significant FIo2 effects on frequency domain indices were observed when compared at the same relative intensity. In conclusion, muscle activation during whole body exercise increases almost linearly with exercise intensity, following a muscle-specific pattern, which is adjusted depending on the FIo2 and the relative intensity of exercise. Both VL and VM are increasingly involved in power output generation with the increase of intensity and the reduction in FIo2. PMID:25225839

  16. Determination of the Absolute Number of Cytokine mRNA Molecules within Individual Activated Human T Cells

    NASA Technical Reports Server (NTRS)

    Karr, Laurel J.; Marshall, Gwen; Hockett, Richard D.; Bucy, R. Pat; Curreri, Peter A. (Technical Monitor)

    2002-01-01

    A primary function of activated T cells is the expression and subsequent secretion of cytokines, which orchestrate the differentiation of other lymphocytes, modulate antigen presenting cell activity, and alter vascular endothelium to mediate an immune response. Since many features of immune regulation probably result from modest alterations of endogenous rates of multiple interacting processes, quantitative analysis of the frequency and specific activity of individual T cells is critically important. Using a coordinated set of quantitative methods, the absolute number of molecules of several key cytokine mRNA species in individual T cells has been determined. The frequency of human blood T cells activated in vitro by mitogens and recall protein antigens was determined by intracellular cytokine protein staining, in situ hybridization for cytokine mRNA, and by limiting dilution analysis for cytokine mRNA+ cells. The absolute number of mRNA molecules was simultaneously determined in both homogenates of the entire population of cells and in individual cells obtained by limiting dilution, using a quantitative, competitive RT-PCR assay. The absolute numbers of mRNA molecules in a population of cells divided by the frequency of individual positive cells, yielded essentially the same number of mRNA molecules per cell as direct analysis of individual cells by limiting dilution analysis. Mean numbers of mRNA per positive cell from both mitogen and antigen activated T cells, using these stimulation conditions, were 6000 for IL-2, 6300 for IFN-gamma, and 1600 for IL-4.

  17. Absolute and relative emission spectroscopy study of 3 cm wide planar radio frequency atmospheric pressure bio-plasma source

    SciTech Connect

    Deng, Xiaolong; Nikiforov, Anton Yu Leys, Christophe; Ionita, Eusebiu-Rosini; Dinescu, Gheorghe

    2015-08-03

    The dynamics of low power atmospheric pressure radio frequency discharge generated in Ar gas in long gap of 3 cm is investigated. This plasma source is characterized and analyzed for possible large scale biomedical applications where low gas temperature and potential-less effluent are required. The discharge forms a homogenous glow-like afterglow in ambient air at input power of 30 W with low gas temperature of 330 K, which is desirable in biomedical applications. With absolute calibrated spectroscopy of the discharge, electron density of 0.4 × 10{sup 18} m{sup −3} and electron temperature of 1.5 eV are obtained from continuum Bremsstrahlung radiation of the source. Time and spatial resolved emission spectroscopy is used to analyze discharge generation mechanism and active species formation. It is found that discharge dynamics strongly correlates with the discharge current waveform. Strong Ar(2p) excited states emission is observed nearby the electrodes surface on a distance up to 200 μm in the plasma sheath region at 10 ns after the current peak, whereas OH(A) emission is uniform along of the interelectrode gap.

  18. Exploring a Black Body Source as an Absolute Radiometric Calibration Standard and Comparison with a NIST Traced Lamp Standard

    NASA Technical Reports Server (NTRS)

    Green, Robert O.; Chrien, Thomas; Sarture, Chuck

    2001-01-01

    Radiometric calibration of the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) is required for the scientific research and application objectives pursued with the spectroscopic measurements. Specifically calibration is required for: inter-comparison of AVIRIS data measured at different locations and at different times; analysis of AVIRIS data with data measured by other instruments; and analysis of AVIRIS data in conjunction with computer models. The primary effect of radiometric calibration is conversion of AVIRIS instrument response values (digitized numbers, or DN) to units of absolute radiance. For example, a figure shows the instrument response spectrum measured by AVIRIS over a portion of Rogers Dry Lake, California, and another figure shows the same spectrum calibrated to radiance. Only the calibrated spectrum may be quantitatively analyzed for science research and application objectives. Since the initial development of the AVIRIS instrument-radiometric calibration has been based upon a 1000-W irradiance lamp with a calibration traced to the National Institute of Standards and Technology (NIST). There are several advantages to this irradiance-lamp calibration approach. First, the considerable effort of NIST backs up the calibration. Second, by changing the distance to the lamp, the output can closely span the radiance levels measured by AVIRIS. Third, this type of standard is widely used. Fourth, these calibrated lamps are comparatively inexpensive. Conversely, there are several disadvantages to this approach as well. First, the lamp is not a primary standard. Second, the lamp output characteristics may change in an unknown manner through time. Third, it is difficult to assess, constrain, or improve the calibration uncertainty delivered with the lamp. In an attempt to explore the effect and potentially address some of these disadvantages a set of analyses and measurements comparing an irradiance lamp with a black-body source have been completed

  19. [Absolute bioavailability of the adenine derivative VMA-99-82 possessing antiviral activity].

    PubMed

    Smirnova, L A; Suchkov, E A; Riabukha, A F; Kuznetsov, K A; Ozerov, A A

    2013-01-01

    Investigation of the main pharmacokinetic parameters of adenine derivative VMA-99-82 in rats showed large values of the half-life (T1/2 = 11.03 h) and the mean retention time of drug molecules in the organism (MRT = 9.53 h). A high rate of the drug concentration decrease in the plasma determines a small value of the area under the pharmacokinetic curve (AUC = 74.96 mg h/ml). The total distribution volume (V(d) = 10.61 l/kg) is 15.8 times greater than the volume of extracellular fluid in the body of rat, which is indicative of a high ability of VMA-99-82 to be distributed and accumulated in the organs and tissues. The absolute bioavailability of VMA-99-82 is 66%. PMID:24605425

  20. Prism-pair interferometry by homodyne interferometers with a common light source for high-accuracy measurement of the absolute refractive index of glasses

    SciTech Connect

    Hori, Yasuaki; Hirai, Akiko; Minoshima, Kaoru

    2011-03-10

    A prism-pair interferometer comprising two homodyne interferometers with a common light source was developed for high-precision measurements of the refractive index of optical glasses with an uncertainty of the order of 10{sup -6}. The two interferometers measure changes in the optical path length in the glass sample and in air, respectively. Uncertainties in the absolute wavelength of the common light source are cancelled out by calculating a ratio between the results from the interferometers. Uncertainties in phase measurement are suppressed by a quadrature detection system. The combined standard uncertainty of the developed system is evaluated as 1.1x10{sup -6}.

  1. Absolute Zero

    NASA Astrophysics Data System (ADS)

    Donnelly, Russell J.; Sheibley, D.; Belloni, M.; Stamper-Kurn, D.; Vinen, W. F.

    2006-12-01

    Absolute Zero is a two hour PBS special attempting to bring to the general public some of the advances made in 400 years of thermodynamics. It is based on the book “Absolute Zero and the Conquest of Cold” by Tom Shachtman. Absolute Zero will call long-overdue attention to the remarkable strides that have been made in low-temperature physics, a field that has produced 27 Nobel Prizes. It will explore the ongoing interplay between science and technology through historical examples including refrigerators, ice machines, frozen foods, liquid oxygen and nitrogen as well as much colder fluids such as liquid hydrogen and liquid helium. A website has been established to promote the series: www.absolutezerocampaign.org. It contains information on the series, aimed primarily at students at the middle school level. There is a wealth of material here and we hope interested teachers will draw their student’s attention to this website and its substantial contents, which have been carefully vetted for accuracy.

  2. Absolute Summ

    NASA Astrophysics Data System (ADS)

    Phillips, Alfred, Jr.

    Summ means the entirety of the multiverse. It seems clear, from the inflation theories of A. Guth and others, that the creation of many universes is plausible. We argue that Absolute cosmological ideas, not unlike those of I. Newton, may be consistent with dynamic multiverse creations. As suggested in W. Heisenberg's uncertainty principle, and with the Anthropic Principle defended by S. Hawking, et al., human consciousness, buttressed by findings of neuroscience, may have to be considered in our models. Predictability, as A. Einstein realized with Invariants and General Relativity, may be required for new ideas to be part of physics. We present here a two postulate model geared to an Absolute Summ. The seedbed of this work is part of Akhnaton's philosophy (see S. Freud, Moses and Monotheism). Most important, however, is that the structure of human consciousness, manifest in Kenya's Rift Valley 200,000 years ago as Homo sapiens, who were the culmination of the six million year co-creation process of Hominins and Nature in Africa, allows us to do the physics that we do. .

  3. Measuring the activity of a 51Cr neutrino source based on the gamma-radiation spectrum

    NASA Astrophysics Data System (ADS)

    Gorbachev, V. V.; Gavrin, V. N.; Ibragimova, T. V.; Kalikhov, A. V.; Malyshkin, Yu. M.; Shikhin, A. A.

    2015-12-01

    A technique for the measurement of activities of intense β sources by measuring the continuous gamma-radiation (internal bremsstrahlung) spectra is developed. A method for reconstructing the spectrum recorded by a germanium semiconductor detector is described. A method for the absolute measurement of the internal bremsstrahlung spectrum of 51Cr is presented.

  4. [HPLC enantioseparation, absolute configuration determination and anti-HIV-1 activity of (±)-F18 enantiomers].

    PubMed

    Zhang, Lei-lei; Xue, Hai; Li, Li; Lu, Xiao-fan; Chen, Zhi-wei; Lu, Gang

    2015-06-01

    Racemic (±)-F18 (10-chloromethyl-11-demethyl-12-oxo-calanolide A), an analog of nature product (+)-calanolide A, is a new anti-HIV-1 nonnucleoside reverse transcript inhibitor (NNRTI). A successful enantioseparation of (±)-F18 offering (R)-F18 and (S)-F18 was achieved by a chiral stationary phase prepared HPLC. Their absolute configurations were determined by measurement of their electronic circular dichroisms combined with modem quantum-chemical calculations. Further investigation revealed that (R)-F18 and (S)-F18 shared a similar anti-HIV activities, however, (R)-F18 was more potent than (S)-F18 against wild-type virus, K101E mutation and P225H mutation pseudoviruses. PMID:26521445

  5. Nitric Oxide Inhibitory Activity and Absolute Configurations of Arylalkenyl α,β-Unsaturated δ/γ-Lactones from Cryptocarya concinna.

    PubMed

    Yang, Bing-Yuan; Kong, Ling-Yi; Wang, Xiao-Bing; Zhang, Yang-Mei; Li, Rui-Jun; Yang, Ming-Hua; Luo, Jian-Guang

    2016-01-22

    During an ongoing exploration of potential anti-inflammatory agents from medicinal plants, eight new arylalkenyl α,β-unsaturated δ-lactones, cryptoconcatones A-H (1-8), and two unusual arylalkenyl α,β-unsaturated γ-lactones, cryptoconcatones I and J (9 and 10), were identified from the leaves and twigs of Cryptocarya concinna. The structures of these compounds were established based on spectroscopic data (MS, 1D/2D NMR), and their absolute configurations were determined with Riguera's method, the modified Mosher's method, chemical derivatization, and the Snatzke chirality rule. Compounds 4-6 and 8-10 showed inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide-induced RAW 264.7 macrophages, particularly compounds 4 and 8-10, with IC50 values of 3.2, 4.2, 3.4, and 7.5 μM, respectively. PMID:26741483

  6. Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers.

    PubMed

    Ohshiro, Taichi; Namatame, Ichiji; Nagai, Kenichiro; Sekiguchi, Takafumi; Doi, Takayuki; Takahashi, Takashi; Akasaka, Kazuaki; Rudel, Lawrence L; Tomoda, Hiroshi; Omura, Satoshi

    2006-09-29

    Fungal beauveriolide III (BeauIII, 1b), a cyclodepsipeptide inhibiting acyl-CoA:cholesterol acyltransferase (ACAT) and showing antiatherogenic activity in mouse models, consists of L-Phe, L-Ala, D-allo-Ile, and 3-hydroxy-4-methyloctanoic acid (HMA) moieties, but the stereochemistry of the HMA part has not until now been fully defined. To determine it, four HMA stereoisomers were synthesized and labeled with (S)-(+)-2-(anthracene-2,3-dicarboximido)-1-propyl trifluoromethane sulfonate (AP-OTf), a chiral fluorescent reagent. The derivatives were separated by HPLC and compared with the natural HMA derivative, which was thereby identified as (3S,4S)HMA in BeauIII. Furthermore, the four beauveriolide III isomers ((3S,4S)BeauIII (23a), (3R,4R)BeauIII (23b), (3R,4S)BeauIII (23c), and (3S,4R)BeauIII (23d)) were synthesized, and it was shown that all the spectral data for 23a were identical with those for natural 1b. Isomers 23a and 23d showed potent inhibitory activity of lipid droplet accumulation in macrophages, while the other two isomers caused weak inhibition. Thus, the 3S configuration of BeauIII is important for this activity. Furthermore, 23a and 23d showed rather specific inhibition against the ACAT1 isozyme. PMID:16995669

  7. Gamma source for active interrogation

    DOEpatents

    Leung, Ka-Ngo; Lou, Tak Pui; Barletta, William A.

    2009-09-29

    A cylindrical gamma generator includes a coaxial RF-driven plasma ion source and target. A hydrogen plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical gamma generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which has many openings. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired.

  8. Gamma source for active interrogation

    SciTech Connect

    Leung, Ka-Ngo; Lou, Tak Pui; Barletta, William A.

    2012-10-02

    A cylindrical gamma generator includes a coaxial RF-driven plasma ion source and target. A hydrogen plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical gamma generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which has many openings. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired.

  9. Muscle activation during exercise in severe acute hypoxia: role of absolute and relative intensity.

    PubMed

    Torres-Peralta, Rafael; Losa-Reyna, José; González-Izal, Miriam; Perez-Suarez, Ismael; Calle-Herrero, Jaime; Izquierdo, Mikel; Calbet, José A L

    2014-12-01

    The aim of this study was to determine the influence of severe acute hypoxia on muscle activation during whole body dynamic exercise. Eleven young men performed four incremental cycle ergometer tests to exhaustion breathing normoxic (FIO2=0.21, two tests) or hypoxic gas (FIO2=0.108, two tests). Surface electromyography (EMG) activities of rectus femoris (RF), vastus medialis (VL), vastus lateralis (VL), and biceps femoris (BF) were recorded. The two normoxic and the two hypoxic tests were averaged to reduce EMG variability. Peak VO2 was 34% lower in hypoxia than in normoxia (p<0.05). The EMG root mean square (RMS) increased with exercise intensity in all muscles (p<0.05), with greater effect in hypoxia than in normoxia in the RF and VM (p<0.05), and a similar trend in VL (p=0.10). At the same relative intensity, the RMS was greater in normoxia than in hypoxia in RF, VL, and BF (p<0.05), with a similar trend in VM (p=0.08). Median frequency increased with exercise intensity (p<0.05), and was higher in hypoxia than in normoxia in VL (p<0.05). Muscle contraction burst duration increased with exercise intensity in VM and VL (p<0.05), without clear effects of FIO2. No significant FIO2 effects on frequency domain indices were observed when compared at the same relative intensity. In conclusion, muscle activation during whole body exercise increases almost linearly with exercise intensity, following a muscle-specific pattern, which is adjusted depending on the FIO2 and the relative intensity of exercise. Both VL and VM are increasingly involved in power output generation with the increase of intensity and the reduction in FIO2. PMID:25225839

  10. Extracellular calcium is not an absolute requirement for tumoricidal activation of RAW-264 macrophage-like cell line.

    PubMed

    Gorecka-Tisera, A M; McCulloch, M A

    1986-08-01

    The purpose of these studies was to establish whether extracellular calcium (Cao2+) plays a role in the process of activation of RAW-264 macrophages for tumor cell killing. We found that these cells were capable of developing a significant level of cytolytic activity under treatment with lymphokine (LK) and lipopolysaccharide (LPS), in the absence of Cao2+ and that responses developed in Ca2+-free media were only 6-18% lower in comparison with the responses developed in the presence of Cao2+. The determination of 45calcium uptake in RAW-264 cells treated with LK and LPS showed that the rate of 45calcium uptake has displayed no increase during either the course of activation or in activated, highly cytolytic cells. Finally, three calcium channel blockers examined here: verapamil, diltiazem and flunarizine, with concentrations ranging from 1 X 10(-7) M - 2.5 X 10(-5) M, showed no inhibitory effect on the process of activation. Nifedipine, another calcium channel blocker, inhibited the development of cytolytic activity with concentrations ranging from 1 X 10(-6) M - 2.5 X 10(-5) M. It could be argued, however, that this inhibition was nonspecific, since this agent was 13 times more potent with regard to the calcium ionophore A23187-induced release of beta-glucuronidase, the function which is entirely dependent on Cao2+. Taken together, these results suggest that Cao2+ is not an absolute requirement for the process of tumoricidal activation of RAW-264 macrophages but it may play some supportive role in this process. PMID:3461096

  11. Advanced Light Source Activity Report 2000

    SciTech Connect

    Greiner, A.; Moxon, L.; Robinson, A.; Tamura, L.

    2001-04-01

    This is an annual report, detailing activities at the Advanced Light Source for the year 2000. It includes highlights of scientific research by users of the facility as well as information about the development of the facility itself.

  12. Left-hemisphere activation is associated with enhanced vocal pitch error detection in musicians with absolute pitch

    PubMed Central

    Behroozmand, Roozbeh; Ibrahim, Nadine; Korzyukov, Oleg; Robin, Donald A.; Larson, Charles R.

    2014-01-01

    The ability to process auditory feedback for vocal pitch control is crucial during speaking and singing. Previous studies have suggested that musicians with absolute pitch (AP) develop specialized left-hemisphere mechanisms for pitch processing. The present study adopted an auditory feedback pitch perturbation paradigm combined with ERP recordings to test the hypothesis whether the neural mechanisms of the left-hemisphere enhance vocal pitch error detection and control in AP musicians compared with relative pitch (RP) musicians and non-musicians (NM). Results showed a stronger N1 response to pitch-shifted voice feedback in the right-hemisphere for both AP and RP musicians compared with the NM group. However, the left-hemisphere P2 component activation was greater in AP and RP musicians compared with NMs and also for the AP compared with RP musicians. The NM group was slower in generating compensatory vocal reactions to feedback pitch perturbation compared with musicians, and they failed to re-adjust their vocal pitch after the feedback perturbation was removed. These findings suggest that in the earlier stages of cortical neural processing, the right hemisphere is more active in musicians for detecting pitch changes in voice feedback. In the later stages, the left-hemisphere is more active during the processing of auditory feedback for vocal motor control and seems to involve specialized mechanisms that facilitate pitch processing in the AP compared with RP musicians. These findings indicate that the left hemisphere mechanisms of AP ability are associated with improved auditory feedback pitch processing during vocal pitch control in tasks such as speaking or singing. PMID:24355545

  13. Absolute number densities of helium metastable atoms determined by atomic absorption spectroscopy in helium plasma-based discharges used as ambient desorption/ionization sources for mass spectrometry

    NASA Astrophysics Data System (ADS)

    Reininger, Charlotte; Woodfield, Kellie; Keelor, Joel D.; Kaylor, Adam; Fernández, Facundo M.; Farnsworth, Paul B.

    2014-10-01

    The absolute number densities of helium atoms in the 2s 3S1 metastable state were determined in four plasma-based ambient desorption/ionization sources by atomic absorption spectroscopy. The plasmas included a high-frequency dielectric barrier discharge (HF-DBD), a low temperature plasma (LTP), and two atmospheric-pressure glow discharges, one with AC excitation and the other with DC excitation. Peak densities in the luminous plumes downstream from the discharge capillaries of the HF-DBD and the LTP were 1.39 × 1012 cm- 3 and 0.011 × 1012 cm- 3, respectively. Neither glow discharge produced a visible afterglow, and no metastable atoms were detected downstream from the capillary exits. However, densities of 0.58 × 1012 cm- 3 and 0.97 × 1012 cm- 3 were measured in the interelectrode regions of the AC and DC glow discharges, respectively. Time-resolved measurements of metastable atom densities revealed significant random variations in the timing of pulsed absorption signals with respect to the voltage waveforms applied to the discharges.

  14. Teaching Absolute Value Meaningfully

    ERIC Educational Resources Information Center

    Wade, Angela

    2012-01-01

    What is the meaning of absolute value? And why do teachers teach students how to solve absolute value equations? Absolute value is a concept introduced in first-year algebra and then reinforced in later courses. Various authors have suggested instructional methods for teaching absolute value to high school students (Wei 2005; Stallings-Roberts…

  15. Measuring the activity of a {sup 51}Cr neutrino source based on the gamma-radiation spectrum

    SciTech Connect

    Gorbachev, V. V. Gavrin, V. N.; Ibragimova, T. V.; Kalikhov, A. V.; Malyshkin, Yu. M.; Shikhin, A. A.

    2015-12-15

    A technique for the measurement of activities of intense β sources by measuring the continuous gamma-radiation (internal bremsstrahlung) spectra is developed. A method for reconstructing the spectrum recorded by a germanium semiconductor detector is described. A method for the absolute measurement of the internal bremsstrahlung spectrum of {sup 51}Cr is presented.

  16. Quantyfing the global lightning activity in absolute unints using Schumann resonance spectral decomposition method and the data from the World ELF Radiolocation Array

    NASA Astrophysics Data System (ADS)

    Dyrda, M.; Kulak, A.; Mlynarczyk, J.; Ostrowski, M.

    2015-12-01

    The extremely low frequency (ELF) electromagnetic waves in the Earth-ionosphere cavity are generated mainly by lightning discharges, originating from the tropical thunderstorm centers. The Earth-ionosphere spherical cavity forms a global resonator for the ELF waves. In a spherical damped resonator, like the Earth-ionosphere cavity, the electromagnetic field is the superposition of the standing wave (resonance) field with the traveling waves field, which transfers the energy from lightning flashes to the global resonator. This component is quite strong close to the source and weakens with source-observer separation and is a major reason for an asymmetric shape of the observational Schumann resonance (SR) power spectra. In physics the process, where the resonant field interference with the background is very well known and in such a case the resonant lines are always asymmetric. However, it is possible to separate the resonance field component from the signal using the spectrum decomposition method proposed by Kułak et al. [2006]. Here, we examine the activity of African thunderstorm center using Schumann resonance data collected by the two ELF stations built under the World ELF Radiolocation Array (WERA) project. The first ELF station in located in Poland and it has been recording data continuously since the end of 2004. In May 2015, another ELF station was installed in the Hugo Wildlife Area in Colorado as part of our project WERA. We binned the ELF data in 10-minute files and we derived the SR power spectra. In the next step the decomposition curve, which describes 7 asymmetric SR modes was fitted to the observational data. Using the algorithm, described in Dyrda et al. [2014], we calculated the distances to the tropical thunderstorm center located in Africa with the spatial resolution of 0.1 Mm. This is done independently for each of the ELF stations from WERA array. Then using the information about the distances and about the size of our magnetic antennas beam

  17. Isolation of austroinulin possessing cell cycle inhibition activity from Blumea glomerata and revision of its absolute configuration.

    PubMed

    Ohtsuki, Takashi; Koyano, Takashi; Kowithayakorn, Thaworn; Yamaguchi, Naoto; Ishibashi, Masami

    2004-12-01

    A labdane-diterpene, austroinulin (1), together with several known flavonoids and sesquiterpenes were isolated from leaves of Blumea glomerata (Compositae). Austroinulin (1) and most of the flavonoids showed cytotoxicity against HeLa cells, while austroinulin (1) exhibited a cell cycle inhibition effect at the G1 stage at the concentration of 15.2 microg/mL (47.2 microM). The absolute configuration of 1 was revised as 5S,6R,7S,8S,9R,10R on the basis of the modified Mosher's method. PMID:15643553

  18. Eosinophil count - absolute

    MedlinePlus

    Eosinophils; Absolute eosinophil count ... the white blood cell count to give the absolute eosinophil count. ... than 500 cells per microliter (cells/mcL). Normal value ranges may vary slightly among different laboratories. Talk ...

  19. Advanced Light Source Activity Report 2002

    SciTech Connect

    Duque, Theresa; Greiner, Annette; Moxon, Elizabeth; Robinson, Arthur; Tamura, Lori

    2003-06-12

    This annual report of the Advanced Light Source details science highlights and facility improvements during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  20. National Synchrotron Light Source 2010 Activity Report

    SciTech Connect

    Rowe, M.; Snyder, K. J.

    2010-12-29

    This is a very exciting period for photon sciences at Brookhaven National Laboratory. It is also a time of unprecedented growth for the Photon Sciences Directorate, which operates the National Synchrotron Light Source (NSLS) and is constructing NSLS-II, both funded by the Department of Energy's Office of Science. Reflecting the quick pace of our activities, we chose the theme 'Discovery at Light Speed' for the directorate's 2010 annual report, a fiscal year bookended by October 2009 and September 2010. The year began with the news that NSLS users Venki Ramakrishnan of Cambridge University (also a former employee in Brookhaven's biology department) and Thomas A. Steitz of Yale University were sharing the 2009 Nobel Prize in Chemistry with Ada E. Yonath of the Weizmann Institute of Science. Every research project has the potential for accolades. In 2010, NSLS users and staff published close to 900 papers, with about 170 appearing in premiere journals. Those are impressive stats for a facility nearly three decades old, testament to the highly dedicated team keeping NSLS at peak performance and the high quality of its user community. Our NSLS users come from a worldwide community of scientists using photons, or light, to carry out research in energy and environmental sciences, physics, materials science, chemistry, biology and medicine. All are looking forward to the new capabilities enabled by NSLS-II, which will offer unprecedented resolution at the nanoscale. The new facility will produce x-rays more than 10,000 times brighter than the current NSLS and host a suite of sophisticated instruments for cutting-edge science. Some of the scientific discoveries we anticipate at NSLS-II will lead to major advances in alternative energy technologies, such as hydrogen and solar. These discoveries could pave the way to: (1) catalysts that split water with sunlight for hydrogen production; (2) materials that can reversibly store large quantities of electricity or hydrogen; (3

  1. Source apportionment of ambient non-methane hydrocarbons in Hong Kong: application of a principal component analysis/absolute principal component scores (PCA/APCS) receptor model.

    PubMed

    Guo, H; Wang, T; Louie, P K K

    2004-06-01

    Receptor-oriented source apportionment models are often used to identify sources of ambient air pollutants and to estimate source contributions to air pollutant concentrations. In this study, a PCA/APCS model was applied to the data on non-methane hydrocarbons (NMHCs) measured from January to December 2001 at two sampling sites: Tsuen Wan (TW) and Central & Western (CW) Toxic Air Pollutants Monitoring Stations in Hong Kong. This multivariate method enables the identification of major air pollution sources along with the quantitative apportionment of each source to pollutant species. The PCA analysis identified four major pollution sources at TW site and five major sources at CW site. The extracted pollution sources included vehicular internal engine combustion with unburned fuel emissions, use of solvent particularly paints, liquefied petroleum gas (LPG) or natural gas leakage, and industrial, commercial and domestic sources such as solvents, decoration, fuel combustion, chemical factories and power plants. The results of APCS receptor model indicated that 39% and 48% of the total NMHCs mass concentrations measured at CW and TW were originated from vehicle emissions, respectively. 32% and 36.4% of the total NMHCs were emitted from the use of solvent and 11% and 19.4% were apportioned to the LPG or natural gas leakage, respectively. 5.2% and 9% of the total NMHCs mass concentrations were attributed to other industrial, commercial and domestic sources, respectively. It was also found that vehicle emissions and LPG or natural gas leakage were the main sources of C(3)-C(5) alkanes and C(3)-C(5) alkenes while aromatics were predominantly released from paints. Comparison of source contributions to ambient NMHCs at the two sites indicated that the contribution of LPG or natural gas at CW site was almost twice that at TW site. High correlation coefficients (R(2) > 0.8) between the measured and predicted values suggested that the PCA/APCS model was applicable for estimation

  2. Recent negative ion source activity at JYFL

    NASA Astrophysics Data System (ADS)

    Kalvas, T.; Tarvainen, O.; Komppula, J.; Laitinen, M.; Sajavaara, T.; Koivisto, H.; Jokinen, A.; Dehnel, M. P.

    2013-02-01

    A filament-powered multicusp ion source for production of H- has been developed for the Jyväskylä Pelletron accelerator for use in ion beam lithography and particle induced X-ray emission applications. The source can be considered conventional with the exception of the filter field being created with an electric magnet for continuous adjustability. A permanent magnet dipoleantidipole electron dump is integrated in the puller electrode. The source provides 50 μA H- beam at 10 keV energy with 0.019 mm mrad 95 % normalized rms emittance through a 2 mm aperture. Lower emittance is achievable by changing the plasma electrode insert to a smaller aperture one if application requires. A new commercial MCC30/15 cyclotron has been installed at the Jyväskylä accelerator laboratory providing 30MeV H+ and 15Mev D+ for use in nuclear physics experiments and applications. The ion source delivered with the cyclotron is a a filament-powered multicusp source capable of about 130 h continuous operation at 1 mA H- output between filament changes. The ion source is located in the cyclotron vault and therefore a significant waiting time for the vault cooldown is required before filament change is possible. This kind of operation is not acceptable as 350 h and longer experiments are expected. Therefore a project for developing a CW 13.56 MHz RF ion source has been initiated. A planar RF antenna replacing the filament back plate of the existing TRIUMF-type ion source has been used in the first tests with 240 μA of H- and 21 mA of electrons measured at 1.5 kW of RF power. Tests with higher RF power levels were prevented by electron beam induced sparking. A new plasma chamber has been built and a new extraction is being designed for the RF ion source. The extraction code IBSimu has recently gone through a major update on how smooth electrode surfaces are implemented in the Poisson solvers. This has made it possible to implement a fast multigrid solver with low memory consumption. Also

  3. Design considerations for neutron activation and neutron source strength monitors for ITER

    SciTech Connect

    Barnes, C.W.; Jassby, D.L.; LeMunyan, G.; Roquemore, A.L.; Walker, C.

    1997-12-31

    The International Thermonuclear Experimental Reactor will require highly accurate measurements of fusion power production in time, space, and energy. Spectrometers in the neutron camera could do it all, but experience has taught us that multiple methods with redundancy and complementary uncertainties are needed. Previously, conceptual designs have been presented for time-integrated neutron activation and time-dependent neutron source strength monitors, both of which will be important parts of the integrated suite of neutron diagnostics for this purpose. The primary goals of the neutron activation system are: to maintain a robust relative measure of fusion energy production with stability and wide dynamic range; to enable an accurate absolute calibration of fusion power using neutronic techniques as successfully demonstrated on JET and TFTR; and to provide a flexible system for materials testing. The greatest difficulty is that the irradiation locations need to be close to plasma with a wide field of view. The routing of the pneumatic system is difficult because of minimum radius of curvature requirements and because of the careful need for containment of the tritium and activated air. The neutron source strength system needs to provide real-time source strength vs. time with {approximately}1 ms resolution and wide dynamic range in a robust and reliable manner with the capability to be absolutely calibrated by in-situ neutron sources as done on TFTR, JT-60U, and JET. In this paper a more detailed look at the expected neutron flux field around ITER is folded into a more complete design of the fission chamber system.

  4. Strategy for the absolute neutron emission measurement on ITER

    SciTech Connect

    Sasao, M.; Bertalot, L.; Ishikawa, M.; Popovichev, S.

    2010-10-15

    Accuracy of 10% is demanded to the absolute fusion measurement on ITER. To achieve this accuracy, a functional combination of several types of neutron measurement subsystem, cross calibration among them, and in situ calibration are needed. Neutron transport calculation shows the suitable calibration source is a DT/DD neutron generator of source strength higher than 10{sup 10} n/s (neutron/second) for DT and 10{sup 8} n/s for DD. It will take eight weeks at the minimum with this source to calibrate flux monitors, profile monitors, and the activation system.

  5. NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 1998.

    SciTech Connect

    ROTHMAN,E.

    1999-05-01

    In FY 1998, following the 50th Anniversary Year of Brookhaven National Laboratory, Brookhaven Science Associates became the new Managers of BNL. The new start is an appropriate time to take stock of past achievements and to renew or confirm future goals. During the 1998 NSLS Annual Users Meeting (described in Part 3 of this Activity Report), the DOE Laboratory Operations Board, Chaired by the Under Secretary for Energy, Ernest Moniz met at BNL. By chance all the NSLS Chairmen except Martin Blume (acting NSLS Chair 84-85) were present as recorded in the picture. Under their leadership the NSLS has improved dramatically: (1) The VUV Ring current has increased from 100 mA in October 1982 to nearly 1 A today. For the following few years 10 Ahrs of current were delivered most weeks - NSLS now exceeds that every day. (2) When the first experiments were performed on the X-ray ring during FY1985 the electron energy was 2 GeV and the current up to 100 mA - the X-Ray Ring now runs routinely at 2.5 GeV and at 2.8 GeV with up to 350 mA of current, with a very much longer beam half-life and improved reliability. (3) Starting in FY 1984 the proposal for the Phase II upgrade, mainly for a building extension and a suite of insertion devices and their associated beamlines, was pursued - the promises were delivered in full so that for some years now the NSLS has been running with two undulators in the VUV Ring and three wigglers and an undulator in the X-Ray Ring. In addition two novel insertion devices have been commissioned in the X13 straight. (4) At the start of FY 1998 the NSLS welcomed its 7000th user - attracted by the opportunity for pursuing research with high quality beams, guaranteed not to be interrupted by 'delivery failures', and welcomed by an efficient and caring user office and first class teams of PRT and NSLS staff. R & D have lead to the possibility of running the X-Ray Ring at the higher energy of 2.8 GeV. Figure 1 shows the first user beam, which was provided

  6. Absolute biological needs.

    PubMed

    McLeod, Stephen

    2014-07-01

    Absolute needs (as against instrumental needs) are independent of the ends, goals and purposes of personal agents. Against the view that the only needs are instrumental needs, David Wiggins and Garrett Thomson have defended absolute needs on the grounds that the verb 'need' has instrumental and absolute senses. While remaining neutral about it, this article does not adopt that approach. Instead, it suggests that there are absolute biological needs. The absolute nature of these needs is defended by appeal to: their objectivity (as against mind-dependence); the universality of the phenomenon of needing across the plant and animal kingdoms; the impossibility that biological needs depend wholly upon the exercise of the abilities characteristic of personal agency; the contention that the possession of biological needs is prior to the possession of the abilities characteristic of personal agency. Finally, three philosophical usages of 'normative' are distinguished. On two of these, to describe a phenomenon or claim as 'normative' is to describe it as value-dependent. A description of a phenomenon or claim as 'normative' in the third sense does not entail such value-dependency, though it leaves open the possibility that value depends upon the phenomenon or upon the truth of the claim. It is argued that while survival needs (or claims about them) may well be normative in this third sense, they are normative in neither of the first two. Thus, the idea of absolute need is not inherently normative in either of the first two senses. PMID:23586876

  7. NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 2004

    SciTech Connect

    MILLER,L.

    2005-05-01

    for the environmental science community, is also very important, as it will help to satisfy the large over subscription rate for this technique at the NSLS. Two other important upgrades that were initiated this past year are the replacement of the X25 wiggler with an undulator and the construction of the X9 undulator beamline for small-angle scattering, with an emphasis on nanoscience research. Another key activity that will benefit all users was the restoration of the x-ray ring lattice symmetry, which reduced the horizontal emittance and made the operational lattice more robust. Similarly, all users will benefit from the introduction of the PASS (Proposal Allocation Safety Scheduling) system this past year, which has greatly improved the process of proposal submission, review, allocation, and scheduling. This coming year we will work to add Rapid Access to the capabilities of PASS. Overall, the success of these and the many other projects that space does not permit listing is a testament to the dedication, hard work, and skill of the NSLS staff. Safety has always been an important issue at a large, complex scientific facility like the NSLS and in 2004 it received renewed attention. Safety is our highest priority and we spent a great deal of time reviewing and refining our safety practices and procedures. A new 'Safety Highlights' web page was created for safety news, and a large number of safety meetings and discussions were held. These reviews and meetings generated many ideas on how the NSLS might improve its safety practices, and we are committed to putting these in place and improving our already very good safety program. We had no lost-time accidents in 2004, which is a notable accomplishment. Our goal is to be best in class and I'm confident that by working together we can achieve that status. Several activities took place this past year to advance our proposal to replace the NSLS with a new National Synchrotron Light Source-II facility. These included a major

  8. Absolute Bioavailability of cis-Mirincamycin and trans-Mirincamycin in Healthy Rhesus Monkeys and Ex Vivo Antimalarial Activity against Plasmodium falciparum ▿

    PubMed Central

    Khemawoot, Phisit; Saunders, David; Rasameesoraj, Maneerat; Melendez, Victor; Imerbsin, Rawiwan; Ohrt, Colin; Fracisco, Susan; Teja-isavadharm, Paktiya

    2011-01-01

    The pharmacokinetics, oral bioavailability, and ex vivo antimalarial activity of mirincamycin isomers in a healthy rhesus monkey model were assessed to support lead optimization of novel nonhemolytic drugs for radical cure and causal prophylaxis of malaria. Fourteen male rhesus monkeys were randomized to four groups, which included cis and trans isomers by the oral and intravenous routes, with vehicle-only controls for each dosing route. Concentration-time data were collected for 7 days and were analyzed by noncompartmental analysis. cis-Mirincamycin had an absolute oral bioavailability of 13.6%, which was slightly higher than that of trans-mirincamycin (11.7%), but this difference was not statistically significant. There was a statistically significant difference between the area under the concentration-time curve from zero to 48 h (AUC0–48) of cis-mirincamycin and that of trans-mirincamycin after oral dosing. When cultured in vitro with the W2 clone of Plasmodium falciparum, the 50% inhibitory concentrations for cis-mirincamycin, trans-mirincamycin, and dihydroartemisinin were 11,300, 12,300, and 2.30 nM, respectively. However, when dosed primate plasma was cultured ex vivo against the W2 clone, both isomers had much greater relative potencies than their in vitro activities relative to results for dihydroartemisinin, an increase of approximately 100-fold for the cis isomer and 150-fold for the trans isomer. Further, oral ex vivo activity was significantly higher than intravenous activity for both isomers, particularly during the first 90 min following dosing, suggesting the first-pass formation of one or more metabolites with blood-stage antimalarial activity. Identification of the metabolic pathways and metabolites may help to further delineate the properties of this class of drugs with previously demonstrated liver-stage antimalarial activity. PMID:21947400

  9. Absolute bioavailability of cis-mirincamycin and trans-mirincamycin in healthy rhesus monkeys and ex vivo antimalarial activity against Plasmodium falciparum.

    PubMed

    Khemawoot, Phisit; Saunders, David; Rasameesoraj, Maneerat; Melendez, Victor; Imerbsin, Rawiwan; Ohrt, Colin; Fracisco, Susan; Teja-Isavadharm, Paktiya

    2011-12-01

    The pharmacokinetics, oral bioavailability, and ex vivo antimalarial activity of mirincamycin isomers in a healthy rhesus monkey model were assessed to support lead optimization of novel nonhemolytic drugs for radical cure and causal prophylaxis of malaria. Fourteen male rhesus monkeys were randomized to four groups, which included cis and trans isomers by the oral and intravenous routes, with vehicle-only controls for each dosing route. Concentration-time data were collected for 7 days and were analyzed by noncompartmental analysis. cis-Mirincamycin had an absolute oral bioavailability of 13.6%, which was slightly higher than that of trans-mirincamycin (11.7%), but this difference was not statistically significant. There was a statistically significant difference between the area under the concentration-time curve from zero to 48 h (AUC(0-48)) of cis-mirincamycin and that of trans-mirincamycin after oral dosing. When cultured in vitro with the W2 clone of Plasmodium falciparum, the 50% inhibitory concentrations for cis-mirincamycin, trans-mirincamycin, and dihydroartemisinin were 11,300, 12,300, and 2.30 nM, respectively. However, when dosed primate plasma was cultured ex vivo against the W2 clone, both isomers had much greater relative potencies than their in vitro activities relative to results for dihydroartemisinin, an increase of approximately 100-fold for the cis isomer and 150-fold for the trans isomer. Further, oral ex vivo activity was significantly higher than intravenous activity for both isomers, particularly during the first 90 min following dosing, suggesting the first-pass formation of one or more metabolites with blood-stage antimalarial activity. Identification of the metabolic pathways and metabolites may help to further delineate the properties of this class of drugs with previously demonstrated liver-stage antimalarial activity. PMID:21947400

  10. Active Control of Aerodynamic Noise Sources

    NASA Technical Reports Server (NTRS)

    Reynolds, Gregory A.

    2001-01-01

    Aerodynamic noise sources become important when propulsion noise is relatively low, as during aircraft landing. Under these conditions, aerodynamic noise from high-lift systems can be significant. The research program and accomplishments described here are directed toward reduction of this aerodynamic noise. Progress toward this objective include correction of flow quality in the Low Turbulence Water Channel flow facility, development of a test model and traversing mechanism, and improvement of the data acquisition and flow visualization capabilities in the Aero. & Fluid Dynamics Laboratory. These developments are described in this report.

  11. Advanced Light Source: Activity report 1993

    SciTech Connect

    Not Available

    1994-11-01

    The Advanced Light Source (ALS) produces the world`s brightest light in the ultraviolet and soft x-ray regions of the spectrum. The first low-energy third-generation synchrotron source in the world, the ALS provides unprecedented opportunities for research in science and technology not possible anywhere else. This year marked the beginning of operations and the start of the user research program at the ALS, which has already produced numerous high quality results. A national user facility located at Lawrence Berkeley Laboratory of the University of California, the ALS is available to researchers from academia, industry, and government laboratories. This report contains the following: (1) director`s message; (2) operations overview; (3) user program; (4) users` executive committee; (5) industrial outreach; (6) accelerator operations; (7) beamline control system; (8) insertion devices; (9) experimental systems; (10) beamline engineering; (11) first results from user beamlines; (12) beamlines for 1994--1995; (13) special events; (14) publications; (15) advisory panels; and (16) ALS staff.

  12. The Enlightenment Revisited: Sources & Interpretations. Learning Activities.

    ERIC Educational Resources Information Center

    Donato, Clorinda; And Others

    This resource book provides 26 learning activities with background materials for teaching about the Enlightenment. Topics include: (1) "What Was the Enlightenment?"; (2) "An Introduction to the Philosophes"; (3) "Was the Enlightenment a Revolt Against Rationalism?"; (4) "Were the Philosophes Democrats? A Comparison of the 'Enlightened' Ideas of…

  13. The central power source in active galaxies

    NASA Astrophysics Data System (ADS)

    Ptak, Roger; Stoner, Ronald

    Potential sources for the central power in AGN are examined. The continuum, emission line profiles, and time variability and broad emission line region for AGN are analyzed. The supermassive black hole hypothesis, the supermassive magnetized core model of Kundt (1978), and the model of Stoner and Ptak (1984) in which the supermassive stars maintain a kind of long-term quasi-stability, but accretion is balanced by mass loss and spherical bursts rather than in jets are considered. It is argued that the hypothesis that the supermassive blackholes are the central engines for AGN is based on theoretical principles; however, AGN emission line profiles and variability suggest a spherical geometry for the observed components of these engines. Also the supermassive black hole models do not account for all the AGN observations.

  14. The absolute path command

    SciTech Connect

    Moody, A.

    2012-05-11

    The ap command traveres all symlinks in a given file, directory, or executable name to identify the final absolute path. It can print just the final path, each intermediate link along with the symlink chan, and the permissions and ownership of each directory component in the final path. It has functionality similar to "which", except that it shows the final path instead of the first path. It is also similar to "pwd", but it can provide the absolute path to a relative directory from the current working directory.

  15. The absolute path command

    Energy Science and Technology Software Center (ESTSC)

    2012-05-11

    The ap command traveres all symlinks in a given file, directory, or executable name to identify the final absolute path. It can print just the final path, each intermediate link along with the symlink chan, and the permissions and ownership of each directory component in the final path. It has functionality similar to "which", except that it shows the final path instead of the first path. It is also similar to "pwd", but it canmore » provide the absolute path to a relative directory from the current working directory.« less

  16. Advanced light source. Activity report 1995

    SciTech Connect

    1996-07-01

    The ALS Activity Report is designed to share the breadth, variety, and interest of the scientific program and ongoing R&D efforts in a form that is accessible to a broad audience. Recent research results are presented in six sections, each representing an important theme in ALS science. These results are designed to demonstrate the capabilities of the ALS, rather than to give a comprehensive review of 1995 experiments. Although the scientific program and facilities report are separate sections, in practice the achievements and accomplishments of users and ALS staff are interdependent. This user-staff collaboration is essential to help us direct our efforts toward meeting the needs of the user community, and to ensure the continued success of the ALS as a premier facility.

  17. National Synchrotron Light Source 2008 Activity Report

    SciTech Connect

    Nasta,K.

    2009-05-01

    Funded by the U.S. Department of Energy's Office of Basic Energy Sciences, the National Synchrotron Light Source (NSLS) is a national user facility that operates two electron storage rings: X-Ray (2.8 GeV, 300 mA) and Vacuum Ultraviolet (VUV) (800 mev, 1.0A). These two rings provide intense light spanning the electromagnetic spectrum -- from very long infrared rays to ultraviolet light and super-short x-rays -- to analyze very small or highly dilute samples. The properties of this light, and the specially designed experimental stations, called beamlines, allow scientists in many diverse disciplines of research to perform experiments not possible at their own laboratories. Each year, about 2,200 scientists from more than 400 universities and companies use the NSLS for research in such diverse fields as biology, physics, chemistry, geology, medicine, and environmental and materials sciences. For example, researchers have used the NSLS to examine the minute details of computer chips, decipher the structures of viruses, probe the density of bone, determine the chemical composition of moon rocks, and reveal countless other mysteries of science. The facility has 65 operating beamlines, with 51 beamlines on the X-Ray Ring and 14 beamlines on the VUV-Infrared Ring. It runs seven days a week, 24 hours a day throughout the year, except during periods of maintenance and studies. Researchers are not charged for beam time, provided that the research results are published in open literature. Proprietary research is conducted on a full-cost-recovery basis. With close to 1,000 publications per year, the NSLS is one of the most prolific scientific facilities in the world. Among the many accolades given to its users and staff, the NSLS has won nine R&D 100 Awards for innovations ranging from a closed orbit feedback system to the first device able to focus a large spread of high-energy x-rays. In addition, a visiting NSLS researcher shared the 2003 Nobel Prize in Chemistry for work

  18. Absolute nuclear material assay using count distribution (LAMBDA) space

    DOEpatents

    Prasad, Mano K.; Snyderman, Neal J.; Rowland, Mark S.

    2015-12-01

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  19. Absolute nuclear material assay using count distribution (LAMBDA) space

    DOEpatents

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2012-06-05

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  20. Using, Seeing, Feeling, and Doing Absolute Value for Deeper Understanding

    ERIC Educational Resources Information Center

    Ponce, Gregorio A.

    2008-01-01

    Using sticky notes and number lines, a hands-on activity is shared that anchors initial student thinking about absolute value. The initial point of reference should help students successfully evaluate numeric problems involving absolute value. They should also be able to solve absolute value equations and inequalities that are typically found in…

  1. Phase 1 immobilized low-activity waste operational source term

    SciTech Connect

    Burbank, D.A.

    1998-03-06

    This report presents an engineering analysis of the Phase 1 privatization feeds to establish an operational source term for storage and disposal of immobilized low-activity waste packages at the Hanford Site. The source term information is needed to establish a preliminary estimate of the numbers of remote-handled and contact-handled waste packages. A discussion of the uncertainties and their impact on the source term and waste package distribution is also presented. It should be noted that this study is concerned with operational impacts only. Source terms used for accident scenarios would differ due to alpha and beta radiation which were not significant in this study.

  2. Electronic Absolute Cartesian Autocollimator

    NASA Technical Reports Server (NTRS)

    Leviton, Douglas B.

    2006-01-01

    An electronic absolute Cartesian autocollimator performs the same basic optical function as does a conventional all-optical or a conventional electronic autocollimator but differs in the nature of its optical target and the manner in which the position of the image of the target is measured. The term absolute in the name of this apparatus reflects the nature of the position measurement, which, unlike in a conventional electronic autocollimator, is based absolutely on the position of the image rather than on an assumed proportionality between the position and the levels of processed analog electronic signals. The term Cartesian in the name of this apparatus reflects the nature of its optical target. Figure 1 depicts the electronic functional blocks of an electronic absolute Cartesian autocollimator along with its basic optical layout, which is the same as that of a conventional autocollimator. Referring first to the optical layout and functions only, this or any autocollimator is used to measure the compound angular deviation of a flat datum mirror with respect to the optical axis of the autocollimator itself. The optical components include an illuminated target, a beam splitter, an objective or collimating lens, and a viewer or detector (described in more detail below) at a viewing plane. The target and the viewing planes are focal planes of the lens. Target light reflected by the datum mirror is imaged on the viewing plane at unit magnification by the collimating lens. If the normal to the datum mirror is parallel to the optical axis of the autocollimator, then the target image is centered on the viewing plane. Any angular deviation of the normal from the optical axis manifests itself as a lateral displacement of the target image from the center. The magnitude of the displacement is proportional to the focal length and to the magnitude (assumed to be small) of the angular deviation. The direction of the displacement is perpendicular to the axis about which the

  3. EMITTING ELECTRONS AND SOURCE ACTIVITY IN MARKARIAN 501

    SciTech Connect

    Mankuzhiyil, Nijil; Ansoldi, Stefano; Persic, Massimo; Rivers, Elizabeth; Rothschild, Richard; Tavecchio, Fabrizio

    2012-07-10

    We study the variation of the broadband spectral energy distribution (SED) of the BL Lac object Mrk 501 as a function of source activity, from quiescent to flaring. Through {chi}{sup 2}-minimization we model eight simultaneous SED data sets with a one-zone synchrotron self-Compton (SSC) model, and examine how model parameters vary with source activity. The emerging variability pattern of Mrk 501 is complex, with the Compton component arising from {gamma}-e scatterings that sometimes are (mostly) Thomson and sometimes (mostly) extreme Klein-Nishina. This can be seen from the variation of the Compton to synchrotron peak distance according to source state. The underlying electron spectra are faint/soft in quiescent states and bright/hard in flaring states. A comparison with Mrk 421 suggests that the typical values of the SSC parameters are different in the two sources: however, in both jets the energy density is particle-dominated in all states.

  4. Active radiation hardening technology for fiber-optic source

    NASA Astrophysics Data System (ADS)

    Yang, Yuanhong; Suo, Xinxin; Yang, Mingwei

    2013-09-01

    We demonstrated an active radiation hardening technology for fiber optic source developed for high performance fiber optic gyroscope. The radiation characteristic of erbium-doped fiber was studied experimentally. The radiation induced attenuation (RIA) at 980nm pump light was identified to be the main reason for the degradation and there was photo-bleaching effect in EDF too. A variable parameters control technology was proposed and taken to keep the 980nm and 1550nm light energy stable and high stability and radiation-resistance fiber source with gauss profile spectrum was realized .The source can stand against more than 50 krad (Si) total radiation dose.

  5. ABSOLUTE POLARIMETRY AT RHIC.

    SciTech Connect

    OKADA; BRAVAR, A.; BUNCE, G.; GILL, R.; HUANG, H.; MAKDISI, Y.; NASS, A.; WOOD, J.; ZELENSKI, Z.; ET AL.

    2007-09-10

    Precise and absolute beam polarization measurements are critical for the RHIC spin physics program. Because all experimental spin-dependent results are normalized by beam polarization, the normalization uncertainty contributes directly to final physics uncertainties. We aimed to perform the beam polarization measurement to an accuracy Of {Delta}P{sub beam}/P{sub beam} < 5%. The absolute polarimeter consists of Polarized Atomic Hydrogen Gas Jet Target and left-right pairs of silicon strip detectors and was installed in the RHIC-ring in 2004. This system features proton-proton elastic scattering in the Coulomb nuclear interference (CNI) region. Precise measurements of the analyzing power A{sub N} of this process has allowed us to achieve {Delta}P{sub beam}/P{sub beam} = 4.2% in 2005 for the first long spin-physics run. In this report, we describe the entire set up and performance of the system. The procedure of beam polarization measurement and analysis results from 2004-2005 are described. Physics topics of AN in the CNI region (four-momentum transfer squared 0.001 < -t < 0.032 (GeV/c){sup 2}) are also discussed. We point out the current issues and expected optimum accuracy in 2006 and the future.

  6. Absolutely relative or relatively absolute: violations of value invariance in human decision making.

    PubMed

    Teodorescu, Andrei R; Moran, Rani; Usher, Marius

    2016-02-01

    Making decisions based on relative rather than absolute information processing is tied to choice optimality via the accumulation of evidence differences and to canonical neural processing via accumulation of evidence ratios. These theoretical frameworks predict invariance of decision latencies to absolute intensities that maintain differences and ratios, respectively. While information about the absolute values of the choice alternatives is not necessary for choosing the best alternative, it may nevertheless hold valuable information about the context of the decision. To test the sensitivity of human decision making to absolute values, we manipulated the intensities of brightness stimuli pairs while preserving either their differences or their ratios. Although asked to choose the brighter alternative relative to the other, participants responded faster to higher absolute values. Thus, our results provide empirical evidence for human sensitivity to task irrelevant absolute values indicating a hard-wired mechanism that precedes executive control. Computational investigations of several modelling architectures reveal two alternative accounts for this phenomenon, which combine absolute and relative processing. One account involves accumulation of differences with activation dependent processing noise and the other emerges from accumulation of absolute values subject to the temporal dynamics of lateral inhibition. The potential adaptive role of such choice mechanisms is discussed. PMID:26022836

  7. Precise Measurement of the Absolute Fluorescence Yield

    NASA Astrophysics Data System (ADS)

    Ave, M.; Bohacova, M.; Daumiller, K.; Di Carlo, P.; di Giulio, C.; San Luis, P. Facal; Gonzales, D.; Hojvat, C.; Hörandel, J. R.; Hrabovsky, M.; Iarlori, M.; Keilhauer, B.; Klages, H.; Kleifges, M.; Kuehn, F.; Monasor, M.; Nozka, L.; Palatka, M.; Petrera, S.; Privitera, P.; Ridky, J.; Rizi, V.; D'Orfeuil, B. Rouille; Salamida, F.; Schovanek, P.; Smida, R.; Spinka, H.; Ulrich, A.; Verzi, V.; Williams, C.

    2011-09-01

    We present preliminary results of the absolute yield of fluorescence emission in atmospheric gases. Measurements were performed at the Fermilab Test Beam Facility with a variety of beam particles and gases. Absolute calibration of the fluorescence yield to 5% level was achieved by comparison with two known light sources--the Cherenkov light emitted by the beam particles, and a calibrated nitrogen laser. The uncertainty of the energy scale of current Ultra-High Energy Cosmic Rays experiments will be significantly improved by the AIRFLY measurement.

  8. Determination of the specific alpha activity of thick sources with a large area ZnS(Ag) scintillation detector.

    PubMed

    Djurasević, M; Vukanac, I; Kandić, A; Nadderd, L; Milosević, Z; Radenković, M

    2007-01-01

    A method for determining the specific alpha activity of thick sources using a large area ZnS(Ag) scintillation detector is presented. In this method a quadratic relationship between the detector response and window thickness is assumed. This method provides a quick estimation of alpha activity in the sample, so it is an indicative method. The aim of this experimental work is to approve theoretical assumption and to develop a standard routine method for absolute alpha measurements of thick contaminated environmental sources. For this purpose reference material U(3)O(8) and spiked standards of soil were used. Measurements of contaminated soil samples from south Serbia showed the practical application of this method. PMID:17383779

  9. Implants as absolute anchorage.

    PubMed

    Rungcharassaeng, Kitichai; Kan, Joseph Y K; Caruso, Joseph M

    2005-11-01

    Anchorage control is essential for successful orthodontic treatment. Each tooth has its own anchorage potential as well as propensity to move when force is applied. When teeth are used as anchorage, the untoward movements of the anchoring units may result in the prolonged treatment time, and unpredictable or less-than-ideal outcome. To maximize tooth-related anchorage, techniques such as differential torque, placing roots into the cortex of the bone, the use of various intraoral devices and/or extraoral appliances have been implemented. Implants, as they are in direct contact with bone, do not possess a periodontal ligament. As a result, they do not move when orthodontic/orthopedic force is applied, and therefore can be used as "absolute anchorage." This article describes different types of implants that have been used as orthodontic anchorage. Their clinical applications and limitations are also discussed. PMID:16463910

  10. Absolute Equilibrium Entropy

    NASA Technical Reports Server (NTRS)

    Shebalin, John V.

    1997-01-01

    The entropy associated with absolute equilibrium ensemble theories of ideal, homogeneous, fluid and magneto-fluid turbulence is discussed and the three-dimensional fluid case is examined in detail. A sigma-function is defined, whose minimum value with respect to global parameters is the entropy. A comparison is made between the use of global functions sigma and phase functions H (associated with the development of various H-theorems of ideal turbulence). It is shown that the two approaches are complimentary though conceptually different: H-theorems show that an isolated system tends to equilibrium while sigma-functions allow the demonstration that entropy never decreases when two previously isolated systems are combined. This provides a more complete picture of entropy in the statistical mechanics of ideal fluids.

  11. Surface Plasma Source Electrode Activation by Surface Impurities

    SciTech Connect

    Dudnikov, Vadim; Johnson, Rolland P.; Han, B.; Murray, S. N.; Pennisi, T. R.; Santana, M.; Stockli, Martin P.; Welton, R. F.

    2011-09-26

    In experiments with RF saddle antenna surface plasma sources (SPS), the efficiency of H{sup -} ion generation was increased by up to a factor of 5 by plasma electrode 'activation', without supplying additional Cs, by heating the collar to high temperature for several hours using hot air flow and plasma discharge. Without cracking or heating the cesium ampoule, but likely with Cs recovery from impurities, the achieved energy efficiency was comparable to that of conventionally cesiated SNS RF sources with an external or internal Cs supply. In the experiments, optimum cesiation was produced (without additional Cs) by the collection and trapping of traces of remnant cesium compounds from SPS surfaces. Such activation by accumulation of impurities on electrode surfaces can be a reason for H{sup -} emission enhancement in other so-called 'volume' negative ion sources.

  12. Absolute calibration of the Auger fluorescence detectors

    SciTech Connect

    Bauleo, P.; Brack, J.; Garrard, L.; Harton, J.; Knapik, R.; Meyhandan, R.; Rovero, A.C.; Tamashiro, A.; Warner, D.

    2005-07-01

    Absolute calibration of the Pierre Auger Observatory fluorescence detectors uses a light source at the telescope aperture. The technique accounts for the combined effects of all detector components in a single measurement. The calibrated 2.5 m diameter light source fills the aperture, providing uniform illumination to each pixel. The known flux from the light source and the response of the acquisition system give the required calibration for each pixel. In the lab, light source uniformity is studied using CCD images and the intensity is measured relative to NIST-calibrated photodiodes. Overall uncertainties are presently 12%, and are dominated by systematics.

  13. Advanced Light Source Activity Report 1997/1998

    SciTech Connect

    Greiner, Annette

    1999-03-01

    This Lawrence Berkeley National Laboratory, Advanced Light Source (ALS) activity report for 1997/98 discusses the following topics: Introduction and Overview; Science Highlights; Facility Report; Special Events; ALS Advisory Panels 1997/98; ALS Staff 1997/98 and Facts and Figures for the year.

  14. Public health genetic counselors: activities, skills, and sources of learning.

    PubMed

    McWalter, Kirsty M; Sdano, Mallory R; Dave, Gaurav; Powell, Karen P; Callanan, Nancy

    2015-06-01

    Specialization within genetic counseling is apparent, with 29 primary specialties listed in the National Society of Genetic Counselors' 2012 Professional Status Survey (PSS). PSS results show a steady proportion of genetic counselors primarily involved in public health, yet do not identify all those performing public health activities. Little is known about the skills needed to perform activities outside of "traditional" genetic counselor roles and the expertise needed to execute those skills. This study aimed to identify genetic counselors engaging in public health activities, the skills used, and the most influential sources of learning for those skills. Participants (N = 155) reported involvement in several public health categories: (a) Education of Public and/or Health Care Providers (n = 80, 52 %), (b) Population-Based Screening Programs (n = 70, 45 %), (c) Lobbying/Public Policy (n = 62, 40 %), (d) Public Health Related Research (n = 47, 30 %), and (e) State Chronic Disease Programs (n = 12, 8 %). Regardless of category, "on the job" was the most common primary source of learning. Genetic counseling training program was the most common secondary source of learning. Results indicate that the number of genetic counselors performing public health activities is likely higher than PSS reports, and that those who may not consider themselves "public health genetic counselors" do participate in public health activities. Genetic counselors learn a diverse skill set in their training programs; some skills are directly applicable to public health genetics, while other public health skills require additional training and/or knowledge. PMID:25475919

  15. Surface Plasma Source Electrode Activation by Surface Impurities

    SciTech Connect

    Dudnikov, Vadim; Han, Baoxi; Johnson, Rolland P.; Murray Jr, S N; Pennisi, Terry R; Santana, Manuel; Stockli, Martin P; Welton, Robert F

    2011-01-01

    In experiments with RF saddle antenna surface plasma sources (SPS), the efficiency of H- ion generation was increased by up to a factor of 5 by long time plasma electrode activation, without adding Cs from Cs supply, by heating the collar to high temperature using hot air flow and plasma discharge. Without cracking or heating the cesium ampoule, but likely with Cs recovery from impurities, the achieved energy efficiency was comparable to that of conventionally cesiated SNS RF sources with an external or internal Cs supply. In the experiments, perfect cesiation was produced (without additional Cs supply) by the collection and trapping of traces of remnant cesium compounds from SPS surfaces.

  16. Sources of the solar wind at solar activity maximum

    NASA Astrophysics Data System (ADS)

    Neugebauer, M.; Liewer, P. C.; Smith, E. J.; Skoug, R. M.; Zurbuchen, T. H.

    2002-12-01

    The photospheric sources of solar wind observed by the Ulysses and ACE spacecraft from 1998 to early 2001 are determined through a two-step mapping process. Solar wind speed measured at the spacecraft is used in a ballistic model to determine a foot point on a source surface at a solar distance of 2.5 solar radii. A potential-field source-surface model is then used to trace the field and flow from the source surface to the photosphere. Comparison of the polarity of the measured interplanetary field with the polarity of the photospheric source region shows good agreement for spacecraft latitudes equatorward of 60°. At higher southern latitudes, the mapping predicts that Ulysses should have observed only outward directed magnetic fields, whereas both polarities were observed. A detailed analysis is performed on four of the solar rotations for which the mapped and observed polarities were in generally good agreement. For those rotations, the solar wind mapped to both coronal holes and active regions. These findings for a period of high solar activity differ from the findings of a similar study of the solar wind in 1994-1995 when solar activity was very low. At solar minimum the fastest wind mapped to the interior of large polar coronal holes while slower wind mapped to the boundaries of those holes or to smaller low-latitude coronal holes. For the data examined in the present study, neither spacecraft detected wind from the small polar coronal holes when they existed and the speed was never as high as that observed by Ulysses at solar minimum. The principal difference between the solar wind from coronal holes and from active regions is that the O7+/O6+ ion ratio is lower for the coronal hole flow, but not as low as in the polar coronal hole flow at solar minimum. Furthermore, the active-region flows appear to be organized into several substreams unlike the more monolithic structure of flows from coronal holes. The boundaries between plasma flows from neighboring

  17. Absolute neutrino mass measurements

    SciTech Connect

    Wolf, Joachim

    2011-10-06

    The neutrino mass plays an important role in particle physics, astrophysics and cosmology. In recent years the detection of neutrino flavour oscillations proved that neutrinos carry mass. However, oscillation experiments are only sensitive to the mass-squared difference of the mass eigenvalues. In contrast to cosmological observations and neutrino-less double beta decay (0v2{beta}) searches, single {beta}-decay experiments provide a direct, model-independent way to determine the absolute neutrino mass by measuring the energy spectrum of decay electrons at the endpoint region with high accuracy.Currently the best kinematic upper limits on the neutrino mass of 2.2eV have been set by two experiments in Mainz and Troitsk, using tritium as beta emitter. The next generation tritium {beta}-experiment KATRIN is currently under construction in Karlsruhe/Germany by an international collaboration. KATRIN intends to improve the sensitivity by one order of magnitude to 0.2eV. The investigation of a second isotope ({sup 137}Rh) is being pursued by the international MARE collaboration using micro-calorimeters to measure the beta spectrum. The technology needed to reach 0.2eV sensitivity is still in the R and D phase. This paper reviews the present status of neutrino-mass measurements with cosmological data, 0v2{beta} decay and single {beta}-decay.

  18. Absolute neutrino mass measurements

    NASA Astrophysics Data System (ADS)

    Wolf, Joachim

    2011-10-01

    The neutrino mass plays an important role in particle physics, astrophysics and cosmology. In recent years the detection of neutrino flavour oscillations proved that neutrinos carry mass. However, oscillation experiments are only sensitive to the mass-squared difference of the mass eigenvalues. In contrast to cosmological observations and neutrino-less double beta decay (0v2β) searches, single β-decay experiments provide a direct, model-independent way to determine the absolute neutrino mass by measuring the energy spectrum of decay electrons at the endpoint region with high accuracy. Currently the best kinematic upper limits on the neutrino mass of 2.2eV have been set by two experiments in Mainz and Troitsk, using tritium as beta emitter. The next generation tritium β-experiment KATRIN is currently under construction in Karlsruhe/Germany by an international collaboration. KATRIN intends to improve the sensitivity by one order of magnitude to 0.2eV. The investigation of a second isotope (137Rh) is being pursued by the international MARE collaboration using micro-calorimeters to measure the beta spectrum. The technology needed to reach 0.2eV sensitivity is still in the R&D phase. This paper reviews the present status of neutrino-mass measurements with cosmological data, 0v2β decay and single β-decay.

  19. Sources of solar wind over the solar activity cycle.

    PubMed

    Poletto, Giannina

    2013-05-01

    Fast solar wind has been recognized, about 40 years ago, to originate in polar coronal holes (CHs), that, since then, have been identified with sources of recurrent high speed wind streams. As of today, however, there is no general consensus about whether there are, within CHs, preferential locations where the solar wind is accelerated. Knowledge of slow wind sources is far from complete as well. Slow wind observed in situ can be traced back to its solar source by backward extrapolation of magnetic fields whose field lines are streamlines of the outflowing plasma. However, this technique often has not the necessary precision for an indisputable identification of the region where wind originates. As the Sun progresses through its activity cycle, different wind sources prevail and contribute to filling the heliosphere. Our present knowledge of different wind sources is here summarized. Also, a Section addresses the problem of wind acceleration in the low corona, as inferred from an analysis of UV data, and illustrates changes between fast and slow wind profiles and possible signatures of changes along the solar cycle. A brief reference to recent work about the deep roots of solar wind and their changes over different solar cycles concludes the review. PMID:25685421

  20. Electrode activation in cesium-free negative ion sources

    SciTech Connect

    Dudnikov, Vadim; Johnson, Rolland P.

    2010-02-15

    Features of emission electrode activation leading to enhancement of negative ion emission in cesium-free discharges are discussed. In some ion sources with cesium-free discharges, the emission of negative ions has been increased significantly by emission electrode activation using strong heating of the negative biased electrode by discharge plasma. A simple explanation of this enhancement is that it is due to an accumulation on the emission surface of the plasma electrode of impurities with low ionization potential that decreases in surface work function and increases the secondary emission of negative ions similar to ''Cesiation.'' The negative biasing of emission surface is important for accumulation and trapping the impurities on the emission surface. To effectively control the activation process it is important to directly detect the evolution of the work function and the impurity concentration during electrode activation with enhancement of negative ion emission.

  1. Mid-infrared absolute spectral responsivity scale based on an absolute cryogenic radiometer and an optical parametric oscillator laser

    NASA Astrophysics Data System (ADS)

    Zhao, Kun; Shi, Xueshun; Chen, Haidong; Liu, Yulong; Liu, Changming; Chen, Kunfeng; Li, Ligong; Gan, Haiyong; Ma, Chong

    2016-06-01

    We are reporting on a laser-based absolute spectral responsivity scale in the mid-infrared spectral range. By using a mid-infrared tunable optical parametric oscillator as the laser source, the absolute responsivity scale has been established by calibrating thin-film thermopile detectors against an absolute cryogenic radiometer. The thin-film thermopile detectors can be then used as transfer standard detectors. The extended uncertainty of the absolute spectral responsivity measurement has been analyzed to be 0.58%–0.68% (k  =  2).

  2. The effect of light-activation sources on tooth bleaching

    PubMed Central

    Baroudi, Kusai; Hassan, Nadia Aly

    2014-01-01

    Vital bleaching is one of the most requested cosmetic dental procedures asked by patients who seek a more pleasing smile. This procedure consists of carbamide or hydrogen peroxide gel applications that can be applied in-office or by the patient (at-home/overnight bleaching system). Some in-office treatments utilise whitening light with the objective of speeding up the whitening process. The objective of this article is to review and summarise the current literature with regard to the effect of light-activation sources on in-office tooth bleaching. A literature search was conducted using Medline, accessed via the National Library of Medicine Pub Med from 2003 to 2013 searching for articles relating to effectiveness of light activation sources on in-office tooth bleaching. This study found conflicting evidence on whether light truly improve tooth whitening. Other factors such as, type of stain, initial tooth colour and subject age which can influence tooth bleaching outcome were discussed. Conclusions: The use of light activator sources with in-office bleaching treatment of vital teeth did not increase the efficacy of bleaching or accelerate the bleaching. PMID:25298598

  3. Brain activity underlying encoding and retrieval of source memory.

    PubMed

    Cansino, Selene; Maquet, Pierre; Dolan, Raymond J; Rugg, Michael D

    2002-10-01

    Neural activity elicited during the encoding and retrieval of source information was investigated with event-related functional magnetic resonance imaging (efMRI). During encoding, 17 subjects performed a natural/artificial judgement on pictures of common objects which were presented randomly in one of the four quadrants of the display. At retrieval, old pictures were mixed with new ones and subjects judged whether each picture was new or old and, if old, indicated in which quadrant it was presented at encoding. During encoding, study items that were later recognized and assigned a correct source judgement elicited greater activity than recognized items given incorrect judgements in a variety of regions, including right lateral occipital and left prefrontal cortex. At retrieval, regions showing greater activity for recognized items given correct versus incorrect source judgements included the right hippocampal formation and the left prefrontal cortex. These findings indicate a role for these regions in the encoding and retrieval of episodic information beyond that required for simple item recognition. PMID:12217968

  4. Absolute Identification by Relative Judgment

    ERIC Educational Resources Information Center

    Stewart, Neil; Brown, Gordon D. A.; Chater, Nick

    2005-01-01

    In unidimensional absolute identification tasks, participants identify stimuli that vary along a single dimension. Performance is surprisingly poor compared with discrimination of the same stimuli. Existing models assume that identification is achieved using long-term representations of absolute magnitudes. The authors propose an alternative…

  5. Be Resolute about Absolute Value

    ERIC Educational Resources Information Center

    Kidd, Margaret L.

    2007-01-01

    This article explores how conceptualization of absolute value can start long before it is introduced. The manner in which absolute value is introduced to students in middle school has far-reaching consequences for their future mathematical understanding. It begins to lay the foundation for students' understanding of algebra, which can change…

  6. Prevalent flucocorticoid and androgen activity in US water sources

    USGS Publications Warehouse

    Stavreva, Diana A.; George, Anuja A.; Klausmeyer, Paul; Varticovski, Lyuba; Sack, Daniel; Voss, Ty C.; Schiltz, R. Louis; Blazer, Vicki; Iwanowiczl, Luke R.; Hager, Gordon L.

    2012-01-01

    Contamination of the environment with endocrine disrupting chemicals (EDCs) is a major health concern. The presence of estrogenic compounds in water and their deleterious effect are well documented. However, detection and monitoring of other classes of EDCs is limited. Here we utilize a high-throughput live cell assay based on sub-cellular relocalization of GFP-tagged glucocorticoid and androgen receptors (GFP-GR and GFP-AR), in combination with gene transcription analysis, to screen for glucocorticoid and androgen activity in water samples. We report previously unrecognized glucocorticoid activity in 27%, and androgen activity in 35% of tested water sources from 14 states in the US. Steroids of both classes impact body development, metabolism, and interfere with reproductive, endocrine, and immune systems. This prevalent contamination could negatively affect wildlife and human populations.

  7. Prevalent Glucocorticoid and Androgen Activity in US Water Sources

    PubMed Central

    Stavreva, Diana A.; George, Anuja A.; Klausmeyer, Paul; Varticovski, Lyuba; Sack, Daniel; Voss, Ty C.; Schiltz, R. Louis; Blazer, Vicki S.; Iwanowicz, Luke R.; Hager, Gordon L.

    2012-01-01

    Contamination of the environment with endocrine disrupting chemicals (EDCs) is a major health concern. The presence of estrogenic compounds in water and their deleterious effect are well documented. However, detection and monitoring of other classes of EDCs is limited. Here we utilize a high-throughput live cell assay based on sub-cellular relocalization of GFP-tagged glucocorticoid and androgen receptors (GFP-GR and GFP-AR), in combination with gene transcription analysis, to screen for glucocorticoid and androgen activity in water samples. We report previously unrecognized glucocorticoid activity in 27%, and androgen activity in 35% of tested water sources from 14 states in the US. Steroids of both classes impact body development, metabolism, and interfere with reproductive, endocrine, and immune systems. This prevalent contamination could negatively affect wildlife and human populations. PMID:23226835

  8. Fundamentals of absolute pyroheliometry and objective characterization. [using a narrow field of view radiometer

    NASA Technical Reports Server (NTRS)

    Crommelynck, D. A.

    1982-01-01

    The radiometric methodology in use with a narrow field of view radiometer for observation of the solar constant is described. The radiation output of the Sun is assumed to be constant, enabling the monitoring of the solar source by an accurately pointed radiometer, and the Sun's output is measured as a function of time. The instrument is described, its angular response considered, and principles for absolute radiometric measurement presented. Active modes of operation are analyzed, taking into consideration instrumental perturbations and sensor efficiency, heating wire effect, cavity sensor efficiency, thermal effects on the surface of the sensitive area, the effect of the field of view limiting system, and the frequency response of the heat flux detector and absolute radiometric system. Performance of absolute measurements with relatively high accuracy is demonstrated.

  9. Hollow cathode plasma source for active spacecraft charge control

    NASA Technical Reports Server (NTRS)

    Deininger, William D.; Aston, Graeme; Pless, Lewis C.

    1987-01-01

    A prototype plasma source spacecraft discharge device has been developed to control overall and differential spacecraft surface charging. The plasma source is based on a unique hollow cathode discharge, where the plasma generation process is contained completely within the cathode. This device can be operated on argon, krypton, or xenon and has a rapid cold start time of less than 4 s. The discharge system design includes a spacecraft-discharge/net-charge sensing circuit which provides the ability to measure the polarity, magnitude, pulse shape, and time duration of a discharging event. Ion currents of up to 325 microA and electron currents ranging from 0.02 to 6.0 A have been extracted from the device. In addition, the spacecraft discharge device successfully discharged capacitively biased plates, from as high as + or - 2500 V, to ground potential, and discharged and clamped actively biased plates at +5 V with respect to ground potential during ground simulation testing.

  10. Absolute cavity pyrgeometer

    DOEpatents

    Reda, Ibrahim

    2013-10-29

    Implementations of the present disclosure involve an apparatus and method to measure the long-wave irradiance of the atmosphere or long-wave source. The apparatus may involve a thermopile, a concentrator and temperature controller. The incoming long-wave irradiance may be reflected from the concentrator to a thermopile receiver located at the bottom of the concentrator to receive the reflected long-wave irradiance. In addition, the thermopile may be thermally connected to a temperature controller to control the device temperature. Through use of the apparatus, the long-wave irradiance of the atmosphere may be calculated from several measurements provided by the apparatus. In addition, the apparatus may provide an international standard of pyrgeometers' calibration that is traceable back to the International System of Units (SI) rather than to a blackbody atmospheric simulator.

  11. Verification of Minimum Detectable Activity for Radiological Threat Source Search

    NASA Astrophysics Data System (ADS)

    Gardiner, Hannah; Myjak, Mitchell; Baciak, James; Detwiler, Rebecca; Seifert, Carolyn

    2015-10-01

    The Department of Homeland Security's Domestic Nuclear Detection Office is working to develop advanced technologies that will improve the ability to detect, localize, and identify radiological and nuclear sources from airborne platforms. The Airborne Radiological Enhanced-sensor System (ARES) program is developing advanced data fusion algorithms for analyzing data from a helicopter-mounted radiation detector. This detector platform provides a rapid, wide-area assessment of radiological conditions at ground level. The NSCRAD (Nuisance-rejection Spectral Comparison Ratios for Anomaly Detection) algorithm was developed to distinguish low-count sources of interest from benign naturally occurring radiation and irrelevant nuisance sources. It uses a number of broad, overlapping regions of interest to statistically compare each newly measured spectrum with the current estimate for the background to identify anomalies. We recently developed a method to estimate the minimum detectable activity (MDA) of NSCRAD in real time. We present this method here and report on the MDA verification using both laboratory measurements and simulated injects on measured backgrounds at or near the detection limits. This work is supported by the US Department of Homeland Security, Domestic Nuclear Detection Office, under competitively awarded contract/IAA HSHQDC-12-X-00376. This support does not constitute an express or implied endorsement on the part of the Gov't.

  12. Absolute distance measurements by variable wavelength interferometry

    NASA Astrophysics Data System (ADS)

    Bien, F.; Camac, M.; Caulfield, H. J.; Ezekiel, S.

    1981-02-01

    This paper describes a laser interferometer which provides absolute distance measurements using tunable lasers. An active feedback loop system, in which the laser frequency is locked to the optical path length difference of the interferometer, is used to tune the laser wavelengths. If the two wavelengths are very close, electronic frequency counters can be used to measure the beat frequency between the two laser frequencies and thus to determine the optical path difference between the two legs of the interferometer.

  13. GROUNDWATER QUALITY MONITORING OF WESTERN COAL STRIP MINING: PRELIMINARY DESIGNS FOR ACTIVE MINE SOURCES OF POLLUTION

    EPA Science Inventory

    Three potential pollution source categories have been identified for Western coal strip mines. These sources include mine stockpiles, mine waters, and miscellaneous active mine sources. TEMPO's stepwise monitoring methodology (Todd et al., 1976) is used to develop groundwater qua...

  14. Antiglycation Activity of Iridoids and Their Food Sources

    PubMed Central

    West, Brett J.; Uwaya, Akemi; Isami, Fumiyuki; Deng, Shixin; Nakajima, Sanae; Jensen, C. Jarakae

    2014-01-01

    Iridoids are dietary phytochemicals that may have the ability to inhibit the formation of advanced glycation end products (AGEs). Three studies were conducted to investigate this anti-AGE potential. First, the inhibition of fluorescence intensity by food-derived iridoids, after 4 days of incubation with bovine serum albumin, glucose, and fructose, was used to evaluate in vitro antiglycation activity. Next, an 8-week open-label pilot study used the AGE Reader to measure changes in the skin autofluorescence of 34 overweight adults who consumed daily a beverage containing food sources of iridoids. Finally, a cross-sectional population study with 3913 people analyzed the relationship between daily iridoid intake and AGE accumulation, as measured by skin autofluorescence with the TruAge scanner. In the in vitro test, deacetylasperulosidic acid and loganic acid both inhibited glycation in a concentration-dependent manner, with respective IC50 values of 3.55 and 2.69 mM. In the pilot study, average skin autofluorescence measurements decreased by 0.12 units (P < 0.05). The cross-sectional population survey revealed that, for every mg of iridoids consumed, there is a corresponding decline in AGE associated age of 0.017 years (P < 0.0001). These results suggest that consumption of dietary sources of iridoids may be a useful antiaging strategy. PMID:26904624

  15. Orally active opioid compounds from a non-poppy source.

    PubMed

    Raffa, Robert B; Beckett, Jaclyn R; Brahmbhatt, Vivek N; Ebinger, Theresa M; Fabian, Chrisjon A; Nixon, Justin R; Orlando, Steven T; Rana, Chintan A; Tejani, Ali H; Tomazic, Robert J

    2013-06-27

    The basic science and clinical use of morphine and other "opioid" drugs are based almost exclusively on the extracts or analogues of compounds isolated from a single source, the opium poppy (Papaver somniferum). However, it now appears that biological diversity has evolved an alternative source. Specifically, at least two alkaloids isolated from the plant Mitragyna speciosa, mitragynine ((E)-2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[3,2-h]quinolizin-2-yl]-3-methoxyprop-2-enoic acid methyl ester; 9-methoxy coryantheidine; MG) and 7-hydroxymitragynine (7-OH-MG), and several synthetic analogues of these natural products display centrally mediated (supraspinal and spinal) antinociceptive (analgesic) activity in various pain models. Several characteristics of these compounds suggest a classic "opioid" mechanism of action: nanomolar affinity for opioid receptors, competitive interaction with the opioid receptor antagonist naloxone, and two-way analgesic cross-tolerance with morphine. However, other characteristics of the compounds suggest novelty, particularly chemical structure and possible greater separation from side effects. We review the chemical and pharmacological properties of these compounds. PMID:23517479

  16. Source localization of brain activity using helium-free interferometer

    NASA Astrophysics Data System (ADS)

    Dammers, Jürgen; Chocholacs, Harald; Eich, Eberhard; Boers, Frank; Faley, Michael; Dunin-Borkowski, Rafal E.; Jon Shah, N.

    2014-05-01

    To detect extremely small magnetic fields generated by the human brain, currently all commercial magnetoencephalography (MEG) systems are equipped with low-temperature (low-Tc) superconducting quantum interference device (SQUID) sensors that use liquid helium for cooling. The limited and increasingly expensive supply of helium, which has seen dramatic price increases recently, has become a real problem for such systems and the situation shows no signs of abating. MEG research in the long run is now endangered. In this study, we report a MEG source localization utilizing a single, highly sensitive SQUID cooled with liquid nitrogen only. Our findings confirm that localization of neuromagnetic activity is indeed possible using high-Tc SQUIDs. We believe that our findings secure the future of this exquisitely sensitive technique and have major implications for brain research and the developments of cost-effective multi-channel, high-Tc SQUID-based MEG systems.

  17. Source localization of brain activity using helium-free interferometer

    SciTech Connect

    Dammers, Jürgen Chocholacs, Harald; Eich, Eberhard; Boers, Frank; Faley, Michael; Dunin-Borkowski, Rafal E.; Jon Shah, N.

    2014-05-26

    To detect extremely small magnetic fields generated by the human brain, currently all commercial magnetoencephalography (MEG) systems are equipped with low-temperature (low-T{sub c}) superconducting quantum interference device (SQUID) sensors that use liquid helium for cooling. The limited and increasingly expensive supply of helium, which has seen dramatic price increases recently, has become a real problem for such systems and the situation shows no signs of abating. MEG research in the long run is now endangered. In this study, we report a MEG source localization utilizing a single, highly sensitive SQUID cooled with liquid nitrogen only. Our findings confirm that localization of neuromagnetic activity is indeed possible using high-T{sub c} SQUIDs. We believe that our findings secure the future of this exquisitely sensitive technique and have major implications for brain research and the developments of cost-effective multi-channel, high-T{sub c} SQUID-based MEG systems.

  18. Intracavitary dosimetry of a high-activity remote loading device with oscillating source.

    PubMed

    Arcovito, G; Piermattei, A; D'Abramo, G; Bassi, F A

    1984-12-01

    Dosimetric experiments have been carried out in order to obtain the dose distribution in water around a Fletcher applicator loaded by a Buchler system containing two 137Cs 148 GBq (4 Ci) sources and one 192Ir 740 GBq (20 Ci) source. The mechanical system which controls the movement of the 192Ir source and the resulting motion of the source are described. The dose distribution around the sources was measured photographically and by a PWT Normal 0.22 cm3 ionisation chamber. The absolute dose rate was measured along the lateral axes of the sources. The measurements of exposure in water near the sources were corrected for the effect due to the finite volume of the chamber. The "quantisation method" described by Cassell (1983) was utilised to calculate the variation of the dose rate along the lateral axes of the sources. The dose distribution around both 192Ir and 137Cs sources was found to be spherical for angles greater than 40 degrees from the longitudinal axes of the sources. A simple algorithm fitting the data for the moving 192Ir source is proposed. A program written in FORTRAN IV and run on a Univac 1100/80 computer has been used to plot dose distributions on anatomical data obtained from CT images. The uncertainties of the measurements and calculations have been examined and the greatest error has been found to be 5.5%. The clinical significance of the treatment method is discussed. PMID:6509290

  19. Absolute brightness temperature measurements at 2.1-mm wavelength

    NASA Technical Reports Server (NTRS)

    Ulich, B. L.

    1974-01-01

    Absolute measurements of the brightness temperatures of the Sun, new Moon, Venus, Mars, Jupiter, Saturn, and Uranus, and of the flux density of DR21 at 2.1-mm wavelength are reported. Relative measurements at 3.5-mm wavelength are also preented which resolve the absolute calibration discrepancy between The University of Texas 16-ft radio telescope and the Aerospace Corporation 15-ft antenna. The use of the bright planets and DR21 as absolute calibration sources at millimeter wavelengths is discussed in the light of recent observations.

  20. Extension of the absolute flux density scale to 22.285 GHz. [radio astronomy

    NASA Technical Reports Server (NTRS)

    Janssen, M. A.; Golden, L. M.; Welch, W. J.

    1974-01-01

    Extending the absolute flux density scale at microwave wavelengths, the absolute flux densities at 22.285 GHz of several standard sources were determined using the absolute calibrations of the 6.1 meter antenna of the Hat Creek Observatory. Interpolation formulas for each nonthermal standard source have been derived by combining these data with those determined at lower frequencies. The suitability of employing the standard sources for calibrating other antennas is discussed.

  1. Preliminary study for improving the VIIRS DNB low light calibration accuracy with ground based active light source

    NASA Astrophysics Data System (ADS)

    Cao, Changyong; Zong, Yuqing; Bai, Yan; Shao, Xi

    2015-09-01

    There is a growing interest in the science and user community in the Visible Infrared Imaging Radiometer Suite (VIIRS) Day/Night Band (DNB) low light detection capabilities at night for quantitative applications such as airglow, geophysical retrievals under lunar illumination, light power estimation, search and rescue, energy use, urban expansion and other human activities. Given the growing interest in the use of the DNB data, a pressing need arises for improving the calibration stability and absolute accuracy of the DNB at low radiances. Currently the low light calibration accuracy was estimated at a moderate 15%-100% while the long-term stability has yet to be characterized. This study investigates selected existing night light point sources from Suomi NPP DNB observations and evaluates the feasibility of SI traceable nightlight source at radiance levels near 3 nW·cm-2·sr-1, that potentially can be installed at selected sites for VIIRS DNB calibration/validation. The illumination geometry, surrounding environment, as well as atmospheric effects are also discussed. The uncertainties of the ground based light source are estimated. This study will contribute to the understanding of how the Earth's atmosphere and surface variability contribute to the stability of the DNB measured radiances, and how to separate them from instrument calibration stability. It presents the need for SI traceable active light sources to monitor the calibration stability, radiometric and geolocation accuracy, and point spread functions of the DNB. Finally, it is also hoped to address whether or not active light sources can be used for detecting environmental changes, such as aerosols.

  2. Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

    PubMed Central

    Zhang, Yong; Jiang, Peixin; Ye, Min; Kim, Sung-Hoon; Jiang, Cheng; Lü, Junxuan

    2012-01-01

    Tanshinones are a class of abietane diterpene compound isolated from Salvia miltiorrhiza (Danshen or Tanshen in Chinese), a well-known herb in Traditional Chinese Medicine (TCM). Since they were first identified in the 1930s, more than 40 lipophilic tanshinones and structurally related compounds have been isolated from Danshen. In recent decades, numerous studies have been conducted to investigate the isolation, identification, synthesis and pharmacology of tanshinones. In addition to the well-studied cardiovascular activities, tanshinones have been investigated more recently for their anti-cancer activities in vitro and in vivo. In this review, we update the herbal and alternative sources of tanshinones, and the pharmacokinetics of selected tanshinones. We discuss anti-cancer properties and identify critical issues for future research. Whereas previous studies have suggested anti-cancer potential of tanshinones affecting multiple cellular processes and molecular targets in cell culture models, data from in vivo potency assessment experiments in preclinical models vary greatly due to lack of uniformity of solvent vehicles and routes of administration. Chemical modifications and novel formulations had been made to address the poor oral bioavailability of tanshinones. So far, human clinical trials have been far from ideal in their design and execution for the purpose of supporting an anti-cancer indication of tanshinones. PMID:23202971

  3. Pomegranate fruit as a rich source of biologically active compounds.

    PubMed

    Sreekumar, Sreeja; Sithul, Hima; Muraleedharan, Parvathy; Azeez, Juberiya Mohammed; Sreeharshan, Sreeja

    2014-01-01

    Pomegranate is a widely used plant having medicinal properties. In this review, we have mainly focused on the already published data from our laboratory pertaining to the effect of methanol extract of pericarp of pomegranate (PME) and have compared it with other relevant literatures on Punica. Earlier, we had shown its antiproliferative effect using human breast (MCF-7, MDA MB-231), and endometrial (HEC-1A), cervical (SiHa, HeLa), and ovarian (SKOV3) cancer cell lines, and normal breast fibroblasts (MCF-10A) at concentration of 20-320 μg/mL. The expressions of selected estrogen responsive genes (PR, pS2, and C-Myc) were downregulated by PME. Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17 β -estradiol. We had further assessed the protective role of PME on skeletal system, using MC3T3-E1 cells. The results indicated that PME (80 μg/mL) significantly increased ALP (Alkaline Phosphatase) activity, supporting its suggested role in modulating osteoblastic cell differentiation. The antiosteoporotic potential of PME was also evaluated in ovariectomized (OVX) rodent model. The results from our studies and from various other studies support the fact that pomegranate fruit is indeed a source of biologically active compounds. PMID:24818149

  4. Absolute dosimetry for extreme-ultraviolet lithography

    NASA Astrophysics Data System (ADS)

    Berger, Kurt W.; Campiotti, Richard H.

    2000-06-01

    The accurate measurement of an exposure dose reaching the wafer on an extreme ultraviolet (EUV) lithographic system has been a technical challenge directly applicable to the evaluation of candidate EUV resist materials and calculating lithography system throughputs. We have developed a dose monitoring sensor system that can directly measure EUV intensities at the wafer plane of a prototype EUV lithographic system. This sensor system, located on the wafer stage adjacent to the electrostatic chuck used to grip wafers, operates by translating the sensor into the aerial image, typically illuminating an 'open' (unpatterned) area on the reticle. The absolute signal strength can be related to energy density at the wafer, and thus used to determine resist sensitivity, and the signal as a function of position can be used to determine illumination uniformity at the wafer plane. Spectral filtering to enhance the detection of 13.4 nm radiation was incorporated into the sensor. Other critical design parameters include the packaging and amplification technologies required to place this device into the space and vacuum constraints of a EUV lithography environment. We describe two approaches used to determine the absolute calibration of this sensor. The first conventional approach requires separate characterization of each element of the sensor. A second novel approach uses x-ray emission from a mildly radioactive iron source to calibrate the absolute response of the entire sensor system (detector and electronics) in a single measurement.

  5. A novel method for the activity measurement of large-area beta reference sources.

    PubMed

    Stanga, D; De Felice, P; Keightley, J; Capogni, M; Ioan, M R

    2016-03-01

    A novel method has been developed for the activity measurement of large-area beta reference sources. It makes use of two emission rate measurements and is based on the weak dependence between the source activity and the activity distribution for a given value of transmission coefficient. The method was checked experimentally by measuring the activity of two ((60)Co and (137)Cs) large-area reference sources constructed from anodized aluminum foils. Measurement results were compared with the activity values measured by gamma spectrometry. For each source, they agree within one standard uncertainty and also agree within the same limits with the certified values of the source activity. PMID:26701656

  6. Absolute radiometry and the solar constant

    NASA Technical Reports Server (NTRS)

    Willson, R. C.

    1974-01-01

    A series of active cavity radiometers (ACRs) are described which have been developed as standard detectors for the accurate measurement of irradiance in absolute units. It is noted that the ACR is an electrical substitution calorimeter, is designed for automatic remote operation in any environment, and can make irradiance measurements in the range from low-level IR fluxes up to 30 solar constants with small absolute uncertainty. The instrument operates in a differential mode by chopping the radiant flux to be measured at a slow rate, and irradiance is determined from two electrical power measurements together with the instrumental constant. Results are reported for measurements of the solar constant with two types of ACRs. The more accurate measurement yielded a value of 136.6 plus or minus 0.7 mW/sq cm (1.958 plus or minus 0.010 cal/sq cm per min).

  7. Hen's egg as a source of valuable biologically active substances.

    PubMed

    Zdrojewicz, Zygmunt; Herman, Marta; Starostecka, Ewa

    2016-01-01

    The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline important nutritive role of hen eggs. Hen egg is a good source of nutrients such as proteins, vitamins (A, B2, B6, B12, D, E, K), minerals and lipids. The significant part of lipids is a group of unsaturated phospholipids, which are components of cell membranes, act protectively on the cardiovascular system and contribute to a decrease of cholesterol level and blood pressure. Therefore, the consumption of unsaturated phospholipids is recommended especially in patients suffering from diseases of the cardiovascular system. Another important substance is egg cystatin, which has a wide spectrum of biological functions, for example the ability to stimulate cell growth, inhibit inflammatory processes and has antibacterial and antiviral properties. Other substance presented in the egg white which helps fight bacteria is lysozyme. It is used in medicine as an aid in antibiotic therapy and analgesic in the course of infection, as well as in tumor malignancies. Among the components contained in the egg yolk there is also immunoglobulin Y which due to its therapeutic importance deserves special attention. Its use offers the possibility of replacing chemotherapeutic agents in the treatment of bacterial infections of digestive system, as well as an opportunity for the development of medicine associated with passive immunization of patients. The egg is a rich source of retinol which gradual depletion in the organism causes many eye pathologies. A very important and useful part of the egg, used in medicine is a shell and its membranes, due to the high collagen content relevant in the treatment of connective tissue diseases. PMID:27383572

  8. Revisiting the Sponge Sources, Stereostructure, and Biological Activity of Cyclocinamide A

    PubMed Central

    Rubio, Brent K.; Robinson, Sarah J.; Avalos, Claudia E.; Valeriote, Frederick A.; de Voogd, Nicole J.; Crews, Phillip

    2009-01-01

    The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to re-isolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S. PMID:18590311

  9. Absolute transition probabilities of phosphorus.

    NASA Technical Reports Server (NTRS)

    Miller, M. H.; Roig, R. A.; Bengtson, R. D.

    1971-01-01

    Use of a gas-driven shock tube to measure the absolute strengths of 21 P I lines and 126 P II lines (from 3300 to 6900 A). Accuracy for prominent, isolated neutral and ionic lines is estimated to be 28 to 40% and 18 to 30%, respectively. The data and the corresponding theoretical predictions are examined for conformity with the sum rules.-

  10. Advanced Light Source activity report 1996/97

    SciTech Connect

    1997-09-01

    Ten years ago, the Advanced Light Source (ALS) existed as a set of drawings, calculations, and ideas. Four years ago, it stored an electron beam for the first time. Today, the ALS has moved from those ideas and beginnings to a robust, third-generation synchrotron user facility, with eighteen beam lines in use, many more in planning or construction phases, and hundreds of users from around the world. Progress from concepts to realities is continuous as the scientific program, already strong in many diverse areas, moves in new directions to meet the needs of researchers into the next century. ALS staff members who develop and maintain the infrastructure for this research are similarly unwilling to rest on their laurels. As a result, the quality of the photon beams the authors deliver, as well as the support they provide to users, continues to improve. The ALS Activity Report is designed to share the results of these efforts in an accessible form for a broad audience. The Scientific Program section, while not comprehensive, shares the breadth, variety, and interest of recent research at the ALS. (The Compendium of User Abstracts and Technical Reports provides a more comprehensive and more technical view.) The Facility Report highlights progress in operations, ongoing accelerator research and development, and beamline instrumentation efforts. Although these Activity Report sections are separate, in practice the achievements of staff and users at the ALS are inseparable. User-staff collaboration is essential as they strive to meet the needs of the user community and to continue the ALS's success as a premier research facility.

  11. Neutron intensity monitor with activation foil for p-Li neutron source for BNCT--Feasibility test of the concept.

    PubMed

    Murata, Isao; Otani, Yuki; Sato, Fuminobu

    2015-12-01

    Proton-lithium (p-Li) reaction is being examined worldwide as a candidate nuclear production reaction for accelerator based neutron source (ABNS) for BNCT. In this reaction, the emitted neutron energy is not so high, below 1 MeV, and especially in backward angles the energy is as low as about 100 keV. The intensity measurement was thus known to be difficult so far. In the present study, a simple method was investigated to monitor the absolute neutron intensity of the p-Li neutron source by employing the foil activation method based on isomer production reactions in order to cover around several hundreds keV. As a result of numerical examination, it was found that (107)Ag, (115)In and (189)Os would be feasible. Their features found out are summarized as follows: (107)Ag: The most convenient foil, since the half life is short. (115)In: The accuracy is the best at 0°, though it cannot be used for backward angles. And (189)Os: Suitable nuclide which can be used in backward angles, though the gamma-ray energy is a little too low. These would be used for p-Li source monitoring depending on measuring purposes in real BNCT scenes. PMID:26242557

  12. Visible Light-Driven Photocatalytic Activity of Oleic Acid-Coated TiO2 Nanoparticles Synthesized from Absolute Ethanol Solution

    NASA Astrophysics Data System (ADS)

    Li, Huihui; Liu, Bin; Yin, Shu; Sato, Tsugio; Wang, Yuhua

    2015-10-01

    The one-step synthesis of oleic acid-coated TiO2 nanoparticles with visible light-driven photocatalytic activity was reported by this manuscript, using oleic acid-ethanol as crucial starting materials. The photocatalytic degradation of nitrogen monoxide (deNOx) in the gas phase was investigated in a continuous reactor using a series of TiO2 semiconductors, prepared from oleic acid- or acetic acid-ethanol solution. The surface modification on TiO2 by organic fatty acid, oleic acid, could reinvest TiO2 photocatalyst with the excellent visible light response. The deNOx ability is almost as high as 30 % destruction in the visible light region ( λ > 510 nm) which is similar to the nitrogen-doped TiO2. Meanwhile, acetic acid, a monobasic acid, has a weaker ability on visible light modification of TiO2.

  13. Absolute calibration of sniffer probes on Wendelstein 7-X

    NASA Astrophysics Data System (ADS)

    Moseev, D.; Laqua, H. P.; Marsen, S.; Stange, T.; Braune, H.; Erckmann, V.; Gellert, F.; Oosterbeek, J. W.

    2016-08-01

    Here we report the first measurements of the power levels of stray radiation in the vacuum vessel of Wendelstein 7-X using absolutely calibrated sniffer probes. The absolute calibration is achieved by using calibrated sources of stray radiation and the implicit measurement of the quality factor of the Wendelstein 7-X empty vacuum vessel. Normalized absolute calibration coefficients agree with the cross-calibration coefficients that are obtained by the direct measurements, indicating that the measured absolute calibration coefficients and stray radiation levels in the vessel are valid. Close to the launcher, the stray radiation in the empty vessel reaches power levels up to 340 kW/m2 per MW injected beam power. Furthest away from the launcher, i.e., half a toroidal turn, still 90 kW/m2 per MW injected beam power is measured.

  14. Absolute calibration of sniffer probes on Wendelstein 7-X.

    PubMed

    Moseev, D; Laqua, H P; Marsen, S; Stange, T; Braune, H; Erckmann, V; Gellert, F; Oosterbeek, J W

    2016-08-01

    Here we report the first measurements of the power levels of stray radiation in the vacuum vessel of Wendelstein 7-X using absolutely calibrated sniffer probes. The absolute calibration is achieved by using calibrated sources of stray radiation and the implicit measurement of the quality factor of the Wendelstein 7-X empty vacuum vessel. Normalized absolute calibration coefficients agree with the cross-calibration coefficients that are obtained by the direct measurements, indicating that the measured absolute calibration coefficients and stray radiation levels in the vessel are valid. Close to the launcher, the stray radiation in the empty vessel reaches power levels up to 340 kW/m(2) per MW injected beam power. Furthest away from the launcher, i.e., half a toroidal turn, still 90 kW/m(2) per MW injected beam power is measured. PMID:27587121

  15. Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines.

    PubMed

    Simoni, D; Roberti, M; Andrisano, V; Manferdini, M; Rondanin, R; Invidiata, F P

    1999-05-30

    In an effort to learn more about the general structure-activity relationships of cocaine with the aim to elucidate those structural features that might confer antagonistic properties to such analogues, we describe herein our synthetic efforts to prepare two-carbon bridge functionalized (methoxylated and hydroxylated) analogues. Our approach makes use of a modification of the classical Willstatter synthesis of cocaine: Mannich type cyclization of acetonedicarboxylic acid monomethyl ester with methylamine hydrochloride and 2-methoxysuccindialdehyde in a citrate buffer solution afforded the 6- and 7-substituted 2-carbomethoxy-3-tropinones 3a,b and 4a,b in approximate yields of 64%. Reduction of the (+/-)-tropinone derivatives was performed with sodium amalgam in a sulfuric acid solution to afford a mixture of (+/-)-methoxyecgonine and (+/-)-methoxypseudoecgonine derivatives 5, 11 and 6, 7, 12, 13. Benzoylation of these alcohols yielded the desired cocaine and pseudococaine-like compounds 8, 14 and 9, 10, 15, 16. Additionally, we show that enzymatic hydrolysis of these cocaine analogues using pig liver esterase (PLE) affords a practical means for achieving their chemical resolution. The enantiomers of the methoxycocaine analogues were also prepared starting from chiral (+)- and (-)-6-methoxytropinone. All new analogues were examined for their ability to displace [3H]mazindol binding and to inhibit high-affinity uptake of [3H]dopamine into striatal nerve ending (synaptosomes). It appeared evident that methoxylation of the cocaine two-carbon bridge provides compounds of particular interest: the Ki for the binding of the methoxypseudococaines is about two to four times smaller than the Ki for inhibition of dopamine uptake, thus enabling these compounds capable of countering the effects of cocaine to some extent. PMID:10418122

  16. Specification of High Activity Gamma-Ray Sources.

    ERIC Educational Resources Information Center

    International Commission on Radiation Units and Measurements, Washington, DC.

    The report is concerned with making recommendations for the specifications of gamma ray sources, which relate to the quantity of radioactive material and the radiation emitted. Primary consideration is given to sources in teletherapy and to a lesser extent those used in industrial radiography and in irradiation units used in industry and research.…

  17. Optomechanics for absolute rotation detection

    NASA Astrophysics Data System (ADS)

    Davuluri, Sankar

    2016-07-01

    In this article, we present an application of optomechanical cavity for the absolute rotation detection. The optomechanical cavity is arranged in a Michelson interferometer in such a way that the classical centrifugal force due to rotation changes the length of the optomechanical cavity. The change in the cavity length induces a shift in the frequency of the cavity mode. The phase shift corresponding to the frequency shift in the cavity mode is measured at the interferometer output to estimate the angular velocity of absolute rotation. We derived an analytic expression to estimate the minimum detectable rotation rate in our scheme for a given optomechanical cavity. Temperature dependence of the rotation detection sensitivity is studied.

  18. The Absolute Spectrum Polarimeter (ASP)

    NASA Technical Reports Server (NTRS)

    Kogut, A. J.

    2010-01-01

    The Absolute Spectrum Polarimeter (ASP) is an Explorer-class mission to map the absolute intensity and linear polarization of the cosmic microwave background and diffuse astrophysical foregrounds over the full sky from 30 GHz to 5 THz. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r much greater than 1O(raised to the power of { -3}) and Compton distortion y < 10 (raised to the power of{-6}). We describe the ASP instrument and mission architecture needed to detect the signature of an inflationary epoch in the early universe using only 4 semiconductor bolometers.

  19. Absolute calibration of optical flats

    DOEpatents

    Sommargren, Gary E.

    2005-04-05

    The invention uses the phase shifting diffraction interferometer (PSDI) to provide a true point-by-point measurement of absolute flatness over the surface of optical flats. Beams exiting the fiber optics in a PSDI have perfect spherical wavefronts. The measurement beam is reflected from the optical flat and passed through an auxiliary optic to then be combined with the reference beam on a CCD. The combined beams include phase errors due to both the optic under test and the auxiliary optic. Standard phase extraction algorithms are used to calculate this combined phase error. The optical flat is then removed from the system and the measurement fiber is moved to recombine the two beams. The newly combined beams include only the phase errors due to the auxiliary optic. When the second phase measurement is subtracted from the first phase measurement, the absolute phase error of the optical flat is obtained.

  20. Measurement of phenotype and absolute number of circulating heparin-binding hemagglutinin, ESAT-6 and CFP-10, and purified protein derivative antigen-specific CD4 T cells can discriminate active from latent tuberculosis infection.

    PubMed

    Hutchinson, Paul; Barkham, Timothy M S; Tang, Wenying; Kemeny, David M; Chee, Cynthia Bin-Eng; Wang, Yee T

    2015-02-01

    The tuberculin skin test (TST) and interferon gamma (IFN-γ) release assays (IGRAs) are used as adjunctive tests for the evaluation of suspected cases of active tuberculosis (TB). However, a positive test does not differentiate latent from active TB. We investigated whether flow cytometric measurement of novel combinations of intracellular cytokines and surface makers on CD4 T cells could differentiate between active and latent TB after stimulation with Mycobacterium tuberculosis-specific proteins. Blood samples from 60 patients referred to the Singapore Tuberculosis Control Unit for evaluation for active TB or as TB contacts were stimulated with purified protein derivative (PPD), ESAT-6 and CFP-10, or heparin-binding hemagglutinin (HBHA). The CD4 T cell cytokine response (IFN-γ, interleukin-2 [IL-2], interleukin-17A [IL-17A], interleukin-22 [IL-22], granulocyte-macrophage colony-stimulating factor [GM-CSF], and tumor necrosis factor alpha [TNF-α]) and surface marker expression (CD27, CXCR3, and CD154) were then measured. We found that the proportion of PPD-specific CD4 T cells, defined as CD154(+) TNF-α(+) cells that were negative for CD27 and positive for GM-CSF, gave the strongest discrimination between subjects with latent and those with active TB (area under the receiver operator characteristic [ROC] curve of 0.9277; P < 0.0001). Also, the proportions and absolute numbers of HBHA-specific CD4 T cells were significantly higher in those with latent TB infection, particularly CD154(+) TNF-α(+) IFN-γ(+) IL-2(+) and CD154(+) TNF-α(+) CXCR3(+). Finally, we found that the ratio of ESAT-6- and CFP-10-responding to HBHA-responding CD4 T cells was significantly different between the two study populations. In conclusion, we found novel markers of M. tuberculosis-specific CD4 cells which differentiate between active and latent TB. PMID:25520147

  1. First Absolutely Calibrated Localized Measurements of Ion Velocity in the MST in Locked and Rotating Plasmas

    NASA Astrophysics Data System (ADS)

    Baltzer, M.; Craig, D.; den Hartog, D. J.; Nornberg, M. D.; Munaretto, S.

    2015-11-01

    An Ion Doppler Spectrometer (IDS) is used on MST for high time-resolution passive and active measurements of impurity ion emission. Absolutely calibrated measurements of flow are difficult because the spectrometer records data within 0.3 nm of the C+5 line of interest, and commercial calibration lamps do not produce lines in this narrow range . A novel optical system was designed to absolutely calibrate the IDS. The device uses an UV LED to produce a broad emission curve in the desired region. A Fabry-Perot etalon filters this light, cutting transmittance peaks into the pattern of the LED emission. An optical train of fused silica lenses focuses the light into the IDS with f/4. A holographic diffuser blurs the light cone to increase homogeneity. Using this light source, the absolute Doppler shift of ion emissions can be measured in MST plasmas. In combination with charge exchange recombination spectroscopy, localized ion velocities can now be measured. Previously, a time-averaged measurement along the chord bisecting the poloidal plane was used to calibrate the IDS; the quality of these central chord calibrations can be characterized with our absolute calibration. Calibration errors may also be quantified and minimized by optimizing the curve-fitting process. Preliminary measurements of toroidal velocity in locked and rotating plasmas will be shown. This work has been supported by the US DOE.

  2. A method for establishing absolute full-energy peak efficiency and its confidence interval for HPGe detectors

    NASA Astrophysics Data System (ADS)

    Rizwan, U.; Chester, A.; Domingo, T.; Starosta, K.; Williams, J.; Voss, P.

    2015-12-01

    A method is proposed for establishing the absolute efficiency calibration of a HPGe detector including the confidence interval in the energy range of 79.6-3451.2 keV. The calibrations were accomplished with the 133Ba, 60Co, 56Co and 152Eu point-like radioactive sources with only the 60Co source being activity calibrated to an accuracy of 2% at the 90% confidence level. All data sets measured from activity calibrated and uncalibrated sources were fit simultaneously using the linearized least squares method. The proposed fit function accounts for scaling of the data taken with activity uncalibrated sources to the data taken with the high accuracy activity calibrated source. The confidence interval for the fit was found analytically using the covariance matrix. Accuracy of the fit was below 3.5% at the 90% confidence level in the 79.6-3451.2 keV energy range.

  3. Source-based neurofeedback methods using EEG recordings: training altered brain activity in a functional brain source derived from blind source separation

    PubMed Central

    White, David J.; Congedo, Marco; Ciorciari, Joseph

    2014-01-01

    A developing literature explores the use of neurofeedback in the treatment of a range of clinical conditions, particularly ADHD and epilepsy, whilst neurofeedback also provides an experimental tool for studying the functional significance of endogenous brain activity. A critical component of any neurofeedback method is the underlying physiological signal which forms the basis for the feedback. While the past decade has seen the emergence of fMRI-based protocols training spatially confined BOLD activity, traditional neurofeedback has utilized a small number of electrode sites on the scalp. As scalp EEG at a given electrode site reflects a linear mixture of activity from multiple brain sources and artifacts, efforts to successfully acquire some level of control over the signal may be confounded by these extraneous sources. Further, in the event of successful training, these traditional neurofeedback methods are likely influencing multiple brain regions and processes. The present work describes the use of source-based signal processing methods in EEG neurofeedback. The feasibility and potential utility of such methods were explored in an experiment training increased theta oscillatory activity in a source derived from Blind Source Separation (BSS) of EEG data obtained during completion of a complex cognitive task (spatial navigation). Learned increases in theta activity were observed in two of the four participants to complete 20 sessions of neurofeedback targeting this individually defined functional brain source. Source-based EEG neurofeedback methods using BSS may offer important advantages over traditional neurofeedback, by targeting the desired physiological signal in a more functionally and spatially specific manner. Having provided preliminary evidence of the feasibility of these methods, future work may study a range of clinically and experimentally relevant brain processes where individual brain sources may be targeted by source-based EEG neurofeedback. PMID

  4. Volcanic eruption source parameters from active and passive microwave sensors

    NASA Astrophysics Data System (ADS)

    Montopoli, Mario; Marzano, Frank S.; Cimini, Domenico; Mereu, Luigi

    2016-04-01

    It is well known, in the volcanology community, that precise information of the source parameters characterising an eruption are of predominant interest for the initialization of the Volcanic Transport and Dispersion Models (VTDM). Source parameters of main interest would be the top altitude of the volcanic plume, the flux of the mass ejected at the emission source, which is strictly related to the cloud top altitude, the distribution of volcanic mass concentration along the vertical column as well as the duration of the eruption and the erupted volume. Usually, the combination of a-posteriori field and numerical studies allow constraining the eruption source parameters for a given volcanic event thus making possible the forecast of ash dispersion and deposition from future volcanic eruptions. So far, remote sensors working at visible and infrared channels (cameras and radiometers) have been mainly used to detect, track and provide estimates of the concentration content and the prevailing size of the particles propagating within the ash clouds up to several thousand of kilometres far from the source as well as track back, a-posteriori, the accuracy of the VATDM outputs thus testing the initial choice made for the source parameters. Acoustic wave (infrasound) and microwave fixed scan radar (voldorad) were also used to infer source parameters. In this work we want to put our attention on the role of sensors operating at microwave wavelengths as complementary tools for the real time estimations of source parameters. Microwaves can benefit of the operability during night and day and a relatively negligible sensitivity to the presence of clouds (non precipitating weather clouds) at the cost of a limited coverage and larger spatial resolution when compared with infrared sensors. Thanks to the aforementioned advantages, the products from microwaves sensors are expected to be sensible mostly to the whole path traversed along the tephra cloud making microwaves particularly

  5. Achieving Climate Change Absolute Accuracy in Orbit

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A.; Young, D. F.; Mlynczak, M. G.; Thome, K. J; Leroy, S.; Corliss, J.; Anderson, J. G.; Ao, C. O.; Bantges, R.; Best, F.; Bowman, K.; Brindley, H.; Butler, J. J.; Collins, W.; Dykema, J. A.; Doelling, D. R.; Feldman, D. R.; Fox, N.; Huang, X.; Holz, R.; Huang, Y.; Jennings, D.; Jin, Z.; Johnson, D. G.; Jucks, K.; Kato, S.; Kratz, D. P.; Liu, X.; Lukashin, C.; Mannucci, A. J.; Phojanamongkolkij, N.; Roithmayr, C. M.; Sandford, S.; Taylor, P. C.; Xiong, X.

    2013-01-01

    The Climate Absolute Radiance and Refractivity Observatory (CLARREO) mission will provide a calibration laboratory in orbit for the purpose of accurately measuring and attributing climate change. CLARREO measurements establish new climate change benchmarks with high absolute radiometric accuracy and high statistical confidence across a wide range of essential climate variables. CLARREO's inherently high absolute accuracy will be verified and traceable on orbit to Système Internationale (SI) units. The benchmarks established by CLARREO will be critical for assessing changes in the Earth system and climate model predictive capabilities for decades into the future as society works to meet the challenge of optimizing strategies for mitigating and adapting to climate change. The CLARREO benchmarks are derived from measurements of the Earth's thermal infrared spectrum (5-50 micron), the spectrum of solar radiation reflected by the Earth and its atmosphere (320-2300 nm), and radio occultation refractivity from which accurate temperature profiles are derived. The mission has the ability to provide new spectral fingerprints of climate change, as well as to provide the first orbiting radiometer with accuracy sufficient to serve as the reference transfer standard for other space sensors, in essence serving as a "NIST [National Institute of Standards and Technology] in orbit." CLARREO will greatly improve the accuracy and relevance of a wide range of space-borne instruments for decadal climate change. Finally, CLARREO has developed new metrics and methods for determining the accuracy requirements of climate observations for a wide range of climate variables and uncertainty sources. These methods should be useful for improving our understanding of observing requirements for most climate change observations.

  6. Inducing in situ, nonlinear soil response applying an active source

    USGS Publications Warehouse

    Johnson, P.A.; Bodin, P.; Gomberg, J.; Pearce, F.; Lawrence, Z.; Menq, F.-Y.

    2009-01-01

    [1] It is well known that soil sites have a profound effect on ground motion during large earthquakes. The complex structure of soil deposits and the highly nonlinear constitutive behavior of soils largely control nonlinear site response at soil sites. Measurements of nonlinear soil response under natural conditions are critical to advancing our understanding of soil behavior during earthquakes. Many factors limit the use of earthquake observations to estimate nonlinear site response such that quantitative characterization of nonlinear behavior relies almost exclusively on laboratory experiments and modeling of wave propagation. Here we introduce a new method for in situ characterization of the nonlinear behavior of a natural soil formation using measurements obtained immediately adjacent to a large vibrator source. To our knowledge, we are the first group to propose and test such an approach. Employing a large, surface vibrator as a source, we measure the nonlinear behavior of the soil by incrementally increasing the source amplitude over a range of frequencies and monitoring changes in the output spectra. We apply a homodyne algorithm for measuring spectral amplitudes, which provides robust signal-to-noise ratios at the frequencies of interest. Spectral ratios are computed between the receivers and the source as well as receiver pairs located in an array adjacent to the source, providing the means to separate source and near-source nonlinearity from pervasive nonlinearity in the soil column. We find clear evidence of nonlinearity in significant decreases in the frequency of peak spectral ratios, corresponding to material softening with amplitude, observed across the array as the source amplitude is increased. The observed peak shifts are consistent with laboratory measurements of soil nonlinearity. Our results provide constraints for future numerical modeling studies of strong ground motion during earthquakes.

  7. Calorimetric method for determination of {sup 51}Cr neutrino source activity

    SciTech Connect

    Veretenkin, E. P. Gavrin, V. N.; Danshin, S. N.; Ibragimova, T. V.; Kozlova, Yu. P.; Mirmov, I. N.

    2015-12-15

    Experimental study of nonstandard neutrino properties using high-intensity artificial neutrino sources requires the activity of the sources to be determined with high accuracy. In the BEST project, a calorimetric system for measurement of the activity of high-intensity (a few MCi) neutrino sources based on {sup 51}Cr with an accuracy of 0.5–1% is created. In the paper, the main factors affecting the accuracy of determining the neutrino source activity are discussed. The calorimetric system design and the calibration results using a thermal simulator of the source are presented.

  8. Information-Driven Active Audio-Visual Source Localization.

    PubMed

    Schult, Niclas; Reineking, Thomas; Kluss, Thorsten; Zetzsche, Christoph

    2015-01-01

    We present a system for sensorimotor audio-visual source localization on a mobile robot. We utilize a particle filter for the combination of audio-visual information and for the temporal integration of consecutive measurements. Although the system only measures the current direction of the source, the position of the source can be estimated because the robot is able to move and can therefore obtain measurements from different directions. These actions by the robot successively reduce uncertainty about the source's position. An information gain mechanism is used for selecting the most informative actions in order to minimize the number of actions required to achieve accurate and precise position estimates in azimuth and distance. We show that this mechanism is an efficient solution to the action selection problem for source localization, and that it is able to produce precise position estimates despite simplified unisensory preprocessing. Because of the robot's mobility, this approach is suitable for use in complex and cluttered environments. We present qualitative and quantitative results of the system's performance and discuss possible areas of application. PMID:26327619

  9. Development of a novel electron source for active space experiments

    NASA Astrophysics Data System (ADS)

    Everding, Daniel

    2013-01-01

    Recent advances in light emitting diode (LED) technology have facilitated a potential remedy to the problems plaguing filament based electron sources. Using spaceworthy LEDs, the photoelectron cathode and its progenitor the ultraviolet cathode (UVC) take advantage of the photoelectric effect to produce electrons for space based experiments. To produce these devices, two species of LED, each producing either ultraviolet or visible radiation, were collected and tested to determine potential photocurrent output. Additionally, materials with requisite photoemission characteristics were collected and tested in vacuum with the LEDs to assess their usefulness as photoelectron sources. Furthermore, circuitry and computer software was compiled, tested, and refined to control the experimental and custodial duties of the UVC and photoelectron cathode while deployed as an electron source in space.

  10. A portable active interrogation system using a switchable AmBe neutron source

    NASA Astrophysics Data System (ADS)

    Allen, Matthew; Hertz, Kristin; Kunz, Christopher; Mascarenhas, Nicholas

    2005-09-01

    Active neutron interrogation is an effective technique used to locate fissionable material. This paper discusses a portable system that utilizes a AmBe neutron source. The AmBe source consists of an americium alpha source and a beryllium target that can be switched into alignment to turn the source on and out of alignment to turn the source off. This offers a battery operated backpack portable source. The detector system that has been fabricated for use with this source is a fifteen tube 3He neutron detector. The results of initial experiments with the detector and MCNP calculations are discussed.

  11. The AFGL absolute gravity program

    NASA Technical Reports Server (NTRS)

    Hammond, J. A.; Iliff, R. L.

    1978-01-01

    A brief discussion of the AFGL's (Air Force Geophysics Laboratory) program in absolute gravity is presented. Support of outside work and in-house studies relating to gravity instrumentation are discussed. A description of the current transportable system is included and the latest results are presented. These results show good agreement with measurements at the AFGL site by an Italian system. The accuracy obtained by the transportable apparatus is better than 0.1 microns sq sec 10 microgal and agreement with previous measurements is within the combined uncertainties of the measurements.

  12. Issues in Humanoid Audition and Sound Source Localization by Active Audition

    NASA Astrophysics Data System (ADS)

    Nakadai, Kazuhiro; Okuno, Hiroshi G.; Kitano, Hiroaki

    In this paper, we present an active audition system which is implemented on the humanoid robot "SIG the humanoid". The audition system for highly intelligent humanoids localizes sound sources and recognizes auditory events in the auditory scene. Active audition reported in this paper enables SIG to track sources by integrating audition, vision, and motor movements. Given the multiple sound sources in the auditory scene, SIG actively moves its head to improve localization by aligning microphones orthogonal to the sound source and by capturing the possible sound sources by vision. However, such an active head movement inevitably creates motor noises.The system adaptively cancels motor noises using motor control signals and the cover acoustics. The experimental result demonstrates that active audition by integration of audition, vision, and motor control attains sound source tracking in variety of conditions.onditions.

  13. Information-Driven Active Audio-Visual Source Localization

    PubMed Central

    Schult, Niclas; Reineking, Thomas; Kluss, Thorsten; Zetzsche, Christoph

    2015-01-01

    We present a system for sensorimotor audio-visual source localization on a mobile robot. We utilize a particle filter for the combination of audio-visual information and for the temporal integration of consecutive measurements. Although the system only measures the current direction of the source, the position of the source can be estimated because the robot is able to move and can therefore obtain measurements from different directions. These actions by the robot successively reduce uncertainty about the source’s position. An information gain mechanism is used for selecting the most informative actions in order to minimize the number of actions required to achieve accurate and precise position estimates in azimuth and distance. We show that this mechanism is an efficient solution to the action selection problem for source localization, and that it is able to produce precise position estimates despite simplified unisensory preprocessing. Because of the robot’s mobility, this approach is suitable for use in complex and cluttered environments. We present qualitative and quantitative results of the system’s performance and discuss possible areas of application. PMID:26327619

  14. Absolute irradiance of the Moon for on-orbit calibration

    USGS Publications Warehouse

    Stone, T.C.; Kieffer, H.H.

    2002-01-01

    The recognized need for on-orbit calibration of remote sensing imaging instruments drives the ROLO project effort to characterize the Moon for use as an absolute radiance source. For over 5 years the ground-based ROLO telescopes have acquired spatially-resolved lunar images in 23 VNIR (Moon diameter ???500 pixels) and 9 SWIR (???250 pixels) passbands at phase angles within ??90 degrees. A numerical model for lunar irradiance has been developed which fits hundreds of ROLO images in each band, corrected for atmospheric extinction and calibrated to absolute radiance, then integrated to irradiance. The band-coupled extinction algorithm uses absorption spectra of several gases and aerosols derived from MODTRAN to fit time-dependent component abundances to nightly observations of standard stars. The absolute radiance scale is based upon independent telescopic measurements of the star Vega. The fitting process yields uncertainties in lunar relative irradiance over small ranges of phase angle and the full range of lunar libration well under 0.5%. A larger source of uncertainty enters in the absolute solar spectral irradiance, especially in the SWIR, where solar models disagree by up to 6%. Results of ROLO model direct comparisons to spacecraft observations demonstrate the ability of the technique to track sensor responsivity drifts to sub-percent precision. Intercomparisons among instruments provide key insights into both calibration issues and the absolute scale for lunar irradiance.

  15. Stitching interferometry: recent results and absolute calibration

    NASA Astrophysics Data System (ADS)

    Bray, Michael

    2004-02-01

    Stitching Interferometry is a method of analysing large optical components using a standard "small" interferometer. This result is obtained by taking multiple overlapping images of the large component, and numerically "stitching" these sub-apertures together. We have already reported the industrial use our Stitching Interferometry systems (Previous SPIE symposia), but experimental results had been lacking because this technique is still new, and users needed to get accustomed to it before producing reliable measurements. We now have more results. We will report user comments and show new, unpublished results. We will discuss sources of error, and show how some of these can be reduced to arbitrarily small values. These will be discussed in some detail. We conclude with a few graphical examples of absolute measurements performed by us.

  16. Simulations as Active Assessment?: Typologizing by Purpose and Source

    ERIC Educational Resources Information Center

    Kollars, Nina A.; Rosen, Amanda M.

    2013-01-01

    Assessment through simulation is something that political science pedagogy has yet to explore in a robust manner. This article advances analysis of social science simulation and assessment by laying out a typology of active-learning activities that isolates and examines their potential for assessment. In short, we argue that there are essentially…

  17. Biochemical assays on plasminogen activators and hormones from kidney sources

    NASA Technical Reports Server (NTRS)

    Barlow, Grant H.; Lewis, Marian L.; Morrison, Dennis R.

    1988-01-01

    Investigations were established for the purpose of analyzing the conditioned media from human embryonic kidney cell subpopulations separated in space by electrophoresis. This data is based on the experiments performed on STS-8 on the continuous flow electrophoresis system. The primary biological activity that was analyzed was plasminogen activator activity, but some assays for erythropoeitin and human granulocyte colony stimulating activity were also performed. It is concluded that a battery of assays are required to completely define the plasminogen activator profile of a conditioned media from cell culture. Each type of assay measures different parts of the mixture and are influenced by different parameters. The functional role of each assay is given along with an indication of which combination of assays are required to answer specific questions. With this type of information it is possible by combinations of assays with mathematical analysis to pinpoint a specific component of the system.

  18. Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities.

    PubMed

    Xu, Beibei; Gao, Song; Wu, Baojian; Yin, Taijun; Hu, Ming

    2014-01-01

    Uridine 5'-diphosphate-glucuronosyltransferase (UGT)1A1 is a major phase II metabolism enzyme responsible for glucuronidation of drugs and endogenous compounds. The purpose of this study was to determine the expression level of UGT1A1 in human liver microsomes and human cell lines by using an isotope label-free LC-MS/MS method. A Waters Ultra performance liquid chromatography (UPLC) system coupled with an API 5500Qtrap mass spectrometer was used for the analysis. Two signature peptides (Pep-1, and Pep-2) were employed to quantify UGT1A1 by multiple reaction monitoring (MRM) approach. Standard addition method was used to validate the assay to account for the matrix effect. 17β-Estradiol was used as the marker substrate to determine UGT1A1 activities. The validated method has a linear range of 200-0.0195nM for both signature peptides. The precision, accuracy, and matrix effect were in acceptable ranges. UGT1A1 expression levels were then determined using 8 individual human liver microsomes, a pooled human liver microsomes, three UGT1A1 genotyped human liver microsomes, and four cell lines (Caco-2, MCF-7, Hela, and HepG2). The correlations study showed that the UGT1A1 protein levels were strongly correlated with its glucuronidation activities in human liver microsomes (R(2)=0.85) and in microsomes prepared from cell lines (R(2)=0.95). Isotope-labeled peptides were not necessary for LC-MS/MS quantitation of proteins. The isotope label-free absolute quantification method used here had good accuracy, sensitivity, linear range, and reproducibility, and were used successfully for the accurate determination of UGT1A1 from tissues and cell lines. PMID:24055854

  19. Hanford Tank Waste - Near Source Treatment of Low Activity Waste

    SciTech Connect

    Ramsey, William Gene

    2013-08-15

    Abstract only. Treatment and disposition of Hanford Site waste as currently planned consists of 100+ waste retrievals, waste delivery through up to 8+ miles of dedicated, in-ground piping, centralized mixing and blending operations- all leading to pre-treatment combination and separation processes followed by vitrification at the Hanford Tank Waste Treatment and Immobilization Plant (WTP). The sequential nature of Tank Farm and WTP operations requires nominally 15-20 years of continuous operations before all waste can be retrieved from many Single Shell Tanks (SSTs). Also, the infrastructure necessary to mobilize and deliver the waste requires significant investment beyond that required for the WTP. Treating waste as closely as possible to individual tanks or groups- as allowed by the waste characteristics- is being investigated to determine the potential to 1) defer, reduce, and/or eliminate infrastructure requirements, and 2) significantly mitigate project risk by reducing the potential and impact of single point failures. The inventory of Hanford waste slated for processing and disposition as LAW is currently managed as high-level waste (HLW), i.e., the separation of fission products and other radionuclides has not commenced. A significant inventory of this waste (over 20M gallons) is in the form of precipitated saltcake maintained in single shell tanks, many of which are identified as potential leaking tanks. Retrieval and transport (as a liquid) must be staged within the waste feed delivery capability established by site infrastructure and WTP. Near Source treatment, if employed, would provide for the separation and stabilization processing necessary for waste located in remote farms (wherein most of the leaking tanks reside) significantly earlier than currently projected. Near Source treatment is intended to address the currently accepted site risk and also provides means to mitigate future issues likely to be faced over the coming decades. This paper

  20. Effect of sole nitrogen sources and temperature on activated sludge

    SciTech Connect

    Mines, R.O. Jr.; Sherrard, J.H.

    1999-07-01

    The effects of temperature on biokinetic coefficients used to design aerobic biological systems treating nitrogen deficient wastewaters at a COD: TKN ratio of 13.7:1 are presented. The impact of temperature on substrate removal, waste biosolids production, and oxygen requirements with the effects of nitrification is delineated at temperatures of 5 C, 10 C, 20 C, and 30 C for two nitrogen sources; ammonia and nitrate. Temperature correction coefficients ({theta}) are presented and the implications for the design and operation of suspended growth biological systems are discussed.

  1. How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

    PubMed Central

    Balderston, Nicholas L.; Schultz, Douglas H.; Baillet, Sylvain; Helmstetter, Fred J.

    2013-01-01

    In trace fear conditioning a conditional stimulus (CS) predicts the occurrence of the unconditional stimulus (UCS), which is presented after a brief stimulus free period (trace interval)1. Because the CS and UCS do not co-occur temporally, the subject must maintain a representation of that CS during the trace interval. In humans, this type of learning requires awareness of the stimulus contingencies in order to bridge the trace interval2-4. However when a face is used as a CS, subjects can implicitly learn to fear the face even in the absence of explicit awareness*. This suggests that there may be additional neural mechanisms capable of maintaining certain types of "biologically-relevant" stimuli during a brief trace interval. Given that the amygdala is involved in trace conditioning, and is sensitive to faces, it is possible that this structure can maintain a representation of a face CS during a brief trace interval. It is challenging to understand how the brain can associate an unperceived face with an aversive outcome, even though the two stimuli are separated in time. Furthermore investigations of this phenomenon are made difficult by two specific challenges. First, it is difficult to manipulate the subject's awareness of the visual stimuli. One common way to manipulate visual awareness is to use backward masking. In backward masking, a target stimulus is briefly presented (< 30 msec) and immediately followed by a presentation of an overlapping masking stimulus5. The presentation of the mask renders the target invisible6-8. Second, masking requires very rapid and precise timing making it difficult to investigate neural responses evoked by masked stimuli using many common approaches. Blood-oxygenation level dependent (BOLD) responses resolve at a timescale too slow for this type of methodology, and real time recording techniques like electroencephalography (EEG) and magnetoencephalography (MEG) have difficulties recovering signal from deep sources. However

  2. Cosmology with negative absolute temperatures

    NASA Astrophysics Data System (ADS)

    Vieira, J. P. P.; Byrnes, Christian T.; Lewis, Antony

    2016-08-01

    Negative absolute temperatures (NAT) are an exotic thermodynamical consequence of quantum physics which has been known since the 1950's (having been achieved in the lab on a number of occasions). Recently, the work of Braun et al. [1] has rekindled interest in negative temperatures and hinted at a possibility of using NAT systems in the lab as dark energy analogues. This paper goes one step further, looking into the cosmological consequences of the existence of a NAT component in the Universe. NAT-dominated expanding Universes experience a borderline phantom expansion (w < ‑1) with no Big Rip, and their contracting counterparts are forced to bounce after the energy density becomes sufficiently large. Both scenarios might be used to solve horizon and flatness problems analogously to standard inflation and bouncing cosmologies. We discuss the difficulties in obtaining and ending a NAT-dominated epoch, and possible ways of obtaining density perturbations with an acceptable spectrum.

  3. Laser ion source activities at Brookhaven National Laboratory

    DOE PAGESBeta

    Kanesue, Takeshi; Okamura, Masahiro

    2015-07-31

    In Brookhaven National Laboratory (BNL), we have been developing laser ion sources for diverse accelerators. Tabletop Nd:YAG lasers with up to several Joules of energy are mainly used to create ablation plasmas for stable operations. The obtained charge states depend on laser power density and target species. Two types of ion extraction schemes, Direct Plasma Injection Scheme (DPIS) and conventional static extraction, are used depending on application. We optimized and select a suitable laser irradiation condition and a beam extraction scheme to meet the requirement of the following accelerator system. We have demonstrated to accelerate more than 5 x 1010more » of C6+ ions using the DPIS. We successfully commissioned low charge ion beam provider to the user facilities in BNL. As a result, to achieve higher current, higher charge state and lower emittance, further studies will continue.« less

  4. Waste tires: A future source of activated carbon?

    SciTech Connect

    1996-01-01

    Millions of used tires are disposed in the United States each year, causing major environmental problems and representing a loss of valuable resources. Currently, over 80% of discarded tires are landfilled (approximately 200 million per year). Because tires disposed in municipal landfills rarely stay buried, regulators, landfill operators, and even the general public are constantly reminded of this problem. These ever-surfacing tires can serve as a breeding ground for disease-causing mosquitoes; in addition, large mounds of tires often catch fire, causing significant air pollution. Recent research indicates that used tires may soon represent a source of carbon-based adsorbents and energy-rich liquid and gaseous hydrocarbons. Details of this research are discussed briefly in this paper. 3 refs., 2 figs.

  5. Laser ion source activities at Brookhaven National Laboratory

    SciTech Connect

    Kanesue, Takeshi; Okamura, Masahiro

    2015-07-31

    In Brookhaven National Laboratory (BNL), we have been developing laser ion sources for diverse accelerators. Tabletop Nd:YAG lasers with up to several Joules of energy are mainly used to create ablation plasmas for stable operations. The obtained charge states depend on laser power density and target species. Two types of ion extraction schemes, Direct Plasma Injection Scheme (DPIS) and conventional static extraction, are used depending on application. We optimized and select a suitable laser irradiation condition and a beam extraction scheme to meet the requirement of the following accelerator system. We have demonstrated to accelerate more than 5 x 1010 of C6+ ions using the DPIS. We successfully commissioned low charge ion beam provider to the user facilities in BNL. As a result, to achieve higher current, higher charge state and lower emittance, further studies will continue.

  6. An open source cryostage and software analysis method for detection of antifreeze activity.

    PubMed

    Buch, J L; Ramløv, H

    2016-06-01

    The aim of this study is to provide the reader with a simple setup that can detect antifreeze proteins (AFP) by inhibition of ice recrystallisation in very small sample sizes. This includes an open source cryostage, a method for preparing and loading samples as well as a software analysis method. The entire setup was tested using hyperactive AFP from the cerambycid beetle, Rhagium mordax. Samples containing AFP were compared to buffer samples, and the results are visualised as crystal radius evolution over time and in absolute change over 30 min. Statistical analysis showed that samples containing AFP could reliably be told apart from controls after only two minutes of recrystallisation. The goal of providing a fast, cheap and easy method for detecting antifreeze proteins in solution was met, and further development of the system can be followed at https://github.com/pechano/cryostage. PMID:27041219

  7. A Mid-infrared Census of Star Formation Activity in Bolocam Galactic Plane Survey Sources

    NASA Astrophysics Data System (ADS)

    Dunham, Miranda K.; Robitaille, Thomas P.; Evans, Neal J., II; Schlingman, Wayne M.; Cyganowski, Claudia J.; Urquhart, James

    2011-04-01

    We present the results of a search for mid-infrared signs of star formation activity in the 1.1 mm sources in the Bolocam Galactic Plane Survey (BGPS). We have correlated the BGPS catalog with available mid-IR Galactic plane catalogs based on the Spitzer Space Telescope GLIMPSE legacy survey and the Midcourse Space Experiment (MSX) Galactic plane survey. We find that 44% (3712 of 8358) of the BGPS sources contain at least one mid-IR source, including 2457 of 5067 (49%) within the area where all surveys overlap (10° < ell < 65°). Accounting for chance alignments between the BGPS and mid-IR sources, we conservatively estimate that 20% of the BPGS sources within the area where all surveys overlap show signs of active star formation. We separate the BGPS sources into four groups based on their probability of star formation activity. Extended Green Objects and Red MSX Sources make up the highest probability group, while the lowest probability group is comprised of "starless" BGPS sources which were not matched to any mid-IR sources. The mean 1.1 mm flux of each group increases with increasing probability of active star formation. We also find that the "starless" BGPS sources are the most compact, while the sources with the highest probability of star formation activity are on average more extended with large skirts of emission. A subsample of 280 BGPS sources with known distances demonstrates that mass and mean H2 column density also increase with probability of star formation activity.

  8. 2001 NSLS ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE).

    SciTech Connect

    CORWIN, M.A.

    2002-05-01

    The year 2001 has been another highly productive year at the NSLS, with over 2500 users, including 720 first time users, conducting nearly 1200 experiments in fields ranging from the life, materials, chemical, and environmental sciences to applied science and technology. An impressive array of highlights from this scientific activity is included in this Activity Report. They include the first demonstration of a direct structural probe of the superconducting ground state in the cuprates by utilizing anomalous soft x-ray resonance effects to selectively enhance the scattering from doped holes. Another highly significant result was the determination of the structure of the potassium channel membrane protein. This is especially significant as it provides insight into how the channel functions and how it selects a particular kind of ion. In the nanoscience area, small angle x-ray scattering measurements played an essential role in determining that preferential sequestering of tailored metal nanocrystals into a self-assembled lamellar diblock copolymer can produce high quality metallodielectric photonic bandgap structures, demonstrating the potential of these nanocomposites for photonic crystal engineering. The infrared microscopy program continued to yield noteworthy results, including an important study that characterized the types and abundances of organic materials in contaminated and uncontaminated sediments from the New York/New Jersey Harbor. These results will be useful in devising improved methods for the destruction or removal of these environmental contaminants.

  9. Absolute oral bioavailability of ciprofloxacin.

    PubMed

    Drusano, G L; Standiford, H C; Plaisance, K; Forrest, A; Leslie, J; Caldwell, J

    1986-09-01

    We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid, in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a randomized, crossover manner 1 week apart orally and as a 10-min intravenous infusion. Half-lives (mean +/- standard deviation) for the intravenous and oral administration arms were 4.2 +/- 0.77 and 4.11 +/- 0.74 h, respectively. The serum clearance rate averaged 28.5 +/- 4.7 liters/h per 1.73 m2 for the intravenous administration arm. The renal clearance rate accounted for approximately 60% of the corresponding serum clearance rate and was 16.9 +/- 3.0 liters/h per 1.73 m2 for the intravenous arm and 17.0 +/- 2.86 liters/h per 1.73 m2 for the oral administration arm. Absorption was rapid, with peak concentrations in serum occurring at 0.71 +/- 0.15 h. Bioavailability, defined as the ratio of the area under the curve from 0 h to infinity for the oral to the intravenous dose, was 69 +/- 7%. We conclude that ciprofloxacin is rapidly absorbed and reliably bioavailable in these healthy volunteers. Further studies with ciprofloxacin should be undertaken in target patient populations under actual clinical circumstances. PMID:3777908

  10. Improving HST Pointing & Absolute Astrometry

    NASA Astrophysics Data System (ADS)

    Lallo, Matthew; Nelan, E.; Kimmer, E.; Cox, C.; Casertano, S.

    2007-05-01

    Accurate absolute astrometry is becoming increasingly important in an era of multi-mission archives and virtual observatories. Hubble Space Telescope's (HST's) Guidestar Catalog II (GSC2) has reduced coordinate error to around 0.25 arcsecond, a factor 2 or more compared with GSC1. With this reduced catalog error, special attention must be given to calibrate and maintain the Fine Guidance Sensors (FGSs) and Science Instruments (SIs) alignments in HST to a level well below this in order to ensure that the accuracy of science product's astrometry keywords and target positioning are limited only by the catalog errors. After HST Servicing Mission 4, such calibrations' improvement in "blind" pointing accuracy will allow for more efficient COS acquisitions. Multiple SIs and FGSs each have their own footprints in the spatially shared HST focal plane. It is the small changes over time in primarily the whole-body positions & orientations of these instruments & guiders relative to one another that is addressed by this work. We describe the HST Cycle 15 program CAL/OTA 11021 which, along with future variants of it, determines and maintains positions and orientations of the SIs and FGSs to better than 50 milli- arcseconds and 0.04 to 0.004 degrees of roll, putting errors associated with the alignment sufficiently below GSC2 errors. We present recent alignment results and assess their errors, illustrate trends, and describe where and how the observer sees benefit from these calibrations when using HST.

  11. Absolute Instability in Coupled-Cavity TWTs

    NASA Astrophysics Data System (ADS)

    Hung, D. M. H.; Rittersdorf, I. M.; Zhang, Peng; Lau, Y. Y.; Simon, D. H.; Gilgenbach, R. M.; Chernin, D.; Antonsen, T. M., Jr.

    2014-10-01

    This paper will present results of our analysis of absolute instability in a coupled-cavity traveling wave tube (TWT). The structure mode at the lower and upper band edges are respectively approximated by a hyperbola in the (omega, k) plane. When the Briggs-Bers criterion is applied, a threshold current for onset of absolute instability is observed at the upper band edge, but not the lower band edge. The nonexistence of absolute instability at the lower band edge is mathematically similar to the nonexistence of absolute instability that we recently demonstrated for a dielectric TWT. The existence of absolute instability at the upper band edge is mathematically similar to the existence of absolute instability in a gyroton traveling wave amplifier. These interesting observations will be discussed, and the practical implications will be explored. This work was supported by AFOSR, ONR, and L-3 Communications Electron Devices.

  12. Compact laser sources for laser designation, ranging and active imaging

    NASA Astrophysics Data System (ADS)

    Goldberg, Lew; Nettleton, John; Schilling, Brad; Trussel, Ward; Hays, Alan

    2007-04-01

    Recent advances in compact solid sate lasers for laser designation, eye-safe range finding and active imaging are described. Wide temperature operation of a compact Nd:YAG laser was achieved by end pumping and the use of multi-λ diode stacks. Such lasers enabled construction of fully operational 4.7 lb laser designator prototypes generating over 50 mJ at 10-20 Hz PRF. Output pulse energy in excess of 100 mJ was demonstrated in a breadboard version of the end-pumped laser. Eye-safe 1.5 μm lasers based on flash-pumped, low PRF, Monoblock lasers have enabled compact STORM laser range finders that have recently been put into production. To achieve higher optical and electrical efficiency needed for higher PRF operation, Monoblock lasers were end-pumped by a laser diode stack. Laser diode end-pumped Monoblock lasers were operated at 10-20 Hz PRF over a wide temperature range (-20 to +50 °C). Compared with bulk compact solid state lasers, fiber lasers are characterized by lower pulse energy, higher PRF's, shorter pulses and higher electrical efficiency. An example of fiber lasers suitable for LIDAR, and atmospheric measurement applications is described. Eye-safe, low intensity diode pumped solid state green warning laser developed for US Army checkpoint and convoy applications is also described.

  13. Absolute negative mobility of interacting Brownian particles

    NASA Astrophysics Data System (ADS)

    Ou, Ya-li; Hu, Cai-tian; Wu, Jian-chun; Ai, Bao-quan

    2015-12-01

    Transport of interacting Brownian particles in a periodic potential is investigated in the presence of an ac force and a dc force. From Brownian dynamic simulations, we find that both the interaction between particles and the thermal fluctuations play key roles in the absolute negative mobility (the particle noisily moves backwards against a small constant bias). When no the interaction acts, there is only one region where the absolute negative mobility occurs. In the presence of the interaction, the absolute negative mobility may appear in multiple regions. The weak interaction can be helpful for the absolute negative mobility, while the strong interaction has a destructive impact on it.

  14. A modified method for the characterisation and activity determination of large area sources.

    PubMed

    Svec, A; Janssen, H; Pernická, L; Klein, R

    2006-01-01

    Large area sources emitting alpha and beta radiations, respectively, are often used for calibrations of surface contamination monitors and meters. It is well known, however, that their properties are strongly influenced by their construction and by their active layer preparation. Non-uniformity of activity distributions over the active surface and the thickness of absorption and backscattering layers cause changes not only in the ratio of particle emission rate and activity but also in emitted particle spectra distributions. Consequently, different sources need to be characterised by one or more parameters related to their emitted particle spectra and used for their activity determination. A modified method based on simple particle absorption spectrometry has been developed. The correlation between a source characteristic parameter and its radiation detection efficiency is utilised for its activity estimation. PMID:16549354

  15. The fast neutron fluence and the activation detector activity calculations using the effective source method and the adjoint function

    SciTech Connect

    Hep, J.; Konecna, A.; Krysl, V.; Smutny, V.

    2011-07-01

    This paper describes the application of effective source in forward calculations and the adjoint method to the solution of fast neutron fluence and activation detector activities in the reactor pressure vessel (RPV) and RPV cavity of a VVER-440 reactor. Its objective is the demonstration of both methods on a practical task. The effective source method applies the Boltzmann transport operator to time integrated source data in order to obtain neutron fluence and detector activities. By weighting the source data by time dependent decay of the detector activity, the result of the calculation is the detector activity. Alternatively, if the weighting is uniform with respect to time, the result is the fluence. The approach works because of the inherent linearity of radiation transport in non-multiplying time-invariant media. Integrated in this way, the source data are referred to as the effective source. The effective source in the forward calculations method thereby enables the analyst to replace numerous intensive transport calculations with a single transport calculation in which the time dependence and magnitude of the source are correctly represented. In this work, the effective source method has been expanded slightly in the following way: neutron source data were performed with few group method calculation using the active core calculation code MOBY-DICK. The follow-up neutron transport calculation was performed using the neutron transport code TORT to perform multigroup calculations. For comparison, an alternative method of calculation has been used based upon adjoint functions of the Boltzmann transport equation. Calculation of the three-dimensional (3-D) adjoint function for each required computational outcome has been obtained using the deterministic code TORT and the cross section library BGL440. Adjoint functions appropriate to the required fast neutron flux density and neutron reaction rates have been calculated for several significant points within the RPV

  16. Seismic exploration of Fuji volcano with active sources in 2003

    NASA Astrophysics Data System (ADS)

    Oikawa, J.; Kagiyama, T.; Tanaka, S.; Miyamachi, H.; Tsutsui, T.; Ikeda, Y.; Katayama, H.; Matsuo, N.; Oshima, H.; Nishimura, Y.; Yamamoto, K.; Watanabe, T.; Yamazaki, F.

    2004-12-01

    the Tanzawa Range to the east. This uplifted body is formed by plate subduction and collision with the Izu Peninsula, and is believed to have influence at significant depth. This is considered to be the reason for the change in the geologic structure beneath Fuji volcano from west to east. The dome structure of the bedrock layer (second layer) directly beneath the summit is considered to have formed in the initial period of volcanic activity that formed Mt. Fuji, leading to the subsequent formation of Komitake volcano, Ko-Fuji volcano and the present day Fuji volcano.

  17. Source localization of ictal epileptic activity investigated by high resolution EEG and validated by SEEG.

    PubMed

    Koessler, Laurent; Benar, Christian; Maillard, Louis; Badier, Jean-Michel; Vignal, Jean Pierre; Bartolomei, Fabrice; Chauvel, Patrick; Gavaret, Martine

    2010-06-01

    High resolution electroencephalography (HR-EEG) combined with source localization methods has mainly been used to study interictal spikes and there have been few studies comparing source localization of scalp ictal patterns with depth EEG. To address this issue, 10 patients with four different scalp ictal patterns (ictal spikes, rhythmic activity, paroxysmal fast activity, obscured) were investigated by both HR-EEG and stereoelectroencephalography (SEEG). Sixty-four scalp-EEG sensors and a sampling rate of 1kHz were used to record scalp ictal patterns. Five different source models (moving dipole, rotating dipole, MUSIC, LORETA, and sLORETA) were used in order to perform source localization. Seven to 10 intracerebral electrodes were implanted during SEEG investigations. For each source model, the concordance between ictal source localization and epileptogenic zone defined by SEEG was assessed. Results were considered to agree if they localized in the same sublobar area as defined by a trained epileptologist. Across the study population, the best concordance between source localization methods and SEEG (9/10) was obtained with equivalent current dipole modeling. MUSIC and LORETA had a concordance of 7/10 whereas sLORETA had a concordance of only 5/10. Four of our patients classified into different groups (ictal spikes, paroxysmal fast activity, obscured) had complete concordance between source localization methods and SEEG. A high signal to noise ratio, a short time window of analysis (<1s) and bandpass filtering around the frequency of rhythmic activity allowed improvement of the source localization results. A high level of agreement between source localization methods and SEEG can be obtained for ictal spike patterns and for scalp-EEG paroxysmal fact activities whereas scalp rhythmic discharges can be accurately localized but originated from seizure propagation network. PMID:20206700

  18. Inequalities, Absolute Value, and Logical Connectives.

    ERIC Educational Resources Information Center

    Parish, Charles R.

    1992-01-01

    Presents an approach to the concept of absolute value that alleviates students' problems with the traditional definition and the use of logical connectives in solving related problems. Uses a model that maps numbers from a horizontal number line to a vertical ray originating from the origin. Provides examples solving absolute value equations and…

  19. Absolute optical metrology : nanometers to kilometers

    NASA Technical Reports Server (NTRS)

    Dubovitsky, Serge; Lay, O. P.; Peters, R. D.; Liebe, C. C.

    2005-01-01

    We provide and overview of the developments in the field of high-accuracy absolute optical metrology with emphasis on space-based applications. Specific work on the Modulation Sideband Technology for Absolute Ranging (MSTAR) sensor is described along with novel applications of the sensor.

  20. Monolithically integrated absolute frequency comb laser system

    DOEpatents

    Wanke, Michael C.

    2016-07-12

    Rather than down-convert optical frequencies, a QCL laser system directly generates a THz frequency comb in a compact monolithically integrated chip that can be locked to an absolute frequency without the need of a frequency-comb synthesizer. The monolithic, absolute frequency comb can provide a THz frequency reference and tool for high-resolution broad band spectroscopy.

  1. Introducing the Mean Absolute Deviation "Effect" Size

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2015-01-01

    This paper revisits the use of effect sizes in the analysis of experimental and similar results, and reminds readers of the relative advantages of the mean absolute deviation as a measure of variation, as opposed to the more complex standard deviation. The mean absolute deviation is easier to use and understand, and more tolerant of extreme…

  2. Investigating Absolute Value: A Real World Application

    ERIC Educational Resources Information Center

    Kidd, Margaret; Pagni, David

    2009-01-01

    Making connections between various representations is important in mathematics. In this article, the authors discuss the numeric, algebraic, and graphical representations of sums of absolute values of linear functions. The initial explanations are accessible to all students who have experience graphing and who understand that absolute value simply…

  3. Absolute Income, Relative Income, and Happiness

    ERIC Educational Resources Information Center

    Ball, Richard; Chernova, Kateryna

    2008-01-01

    This paper uses data from the World Values Survey to investigate how an individual's self-reported happiness is related to (i) the level of her income in absolute terms, and (ii) the level of her income relative to other people in her country. The main findings are that (i) both absolute and relative income are positively and significantly…

  4. HerMES: disentangling active galactic nuclei and star formation in the radio source population

    NASA Astrophysics Data System (ADS)

    Rawlings, J. I.; Page, M. J.; Symeonidis, M.; Bock, J.; Cooray, A.; Farrah, D.; Guo, K.; Hatziminaoglou, E.; Ibar, E.; Oliver, S. J.; Roseboom, I. G.; Scott, Douglas; Seymour, N.; Vaccari, M.; Wardlow, J. L.

    2015-10-01

    We separate the extragalactic radio source population above ˜50 μJy into active galactic nuclei (AGN) and star-forming sources. The primary method of our approach is to fit the infrared spectral energy distributions (SEDs), constructed using Spitzer/IRAC (Infrared Array Camera) and Multiband Imaging Photometer for Spitzer (MIPS) and Herschel/SPIRE photometry, of 380 radio sources in the Extended Chandra Deep Field-South. From the fitted SEDs, we determine the relative AGN and star-forming contributions to their infrared emission. With the inclusion of other AGN diagnostics such as X-ray luminosity, Spitzer/IRAC colours, radio spectral index and the ratio of star-forming total infrared flux to k-corrected 1.4 GHz flux density, qIR, we determine whether the radio emission in these sources is powered by star formation or by an AGN. The majority of these radio sources (60 per cent) show the signature of an AGN at some wavelength. Of the sources with AGN signatures, 58 per cent are hybrid systems for which the radio emission is being powered by star formation. This implies that radio sources which have likely been selected on their star formation have a high AGN fraction. Below a 1.4 GHz flux density of 1 mJy, along with finding a strong contribution to the source counts from pure star-forming sources, we find that hybrid sources constitute 20-65 per cent of the sources. This result suggests that hybrid sources have a significant contribution, along with sources that do not host a detectable AGN, to the observed flattening of the source counts at ˜1 mJy for the extragalactic radio source population.

  5. Dipole source localization of interictal epileptiform activity in temporal lobe epilepsy with medial temporal lesion.

    PubMed

    Mine, S; Iwasa, H; Nakajima, Y; Yamaura, A

    2000-02-01

    Dipole sources of interictal epileptiform activities recorded by conventional electroencephalogram (EEG) were estimated using the dipole tracing method. Four cases of temporal lobe epilepsy with medial temporal lesions were studied. Two patients with hippocampal sclerosis, one patient with granulation in the hippocampus and one patient with cavernous angioma were involved in the study. Interictal epileptiform activities were classified into two patterns according to the topography of spikes. They were widespread spikes over the parasagittal electrodes (parasagittal spikes) and restricted spikes at the temporal electrodes (temporal spikes). Dipole sources of parasagittal spikes were localized in the medio-basal temporal lobe with vertically orientated vector moment. Dipole sources of temporal spikes were localized in the medio-basal temporal lobe with horizontally orientated vector moment. Locations of dipoles and directions of vector moments were consistent with topography and polarity of spikes. The difference in the two patterns of interictal epileptiform activities was derived from the difference in the direction of the vector moment of dipole sources. There was no difference in the location of dipole sources. Both the dipole sources and the lesions were localized in the same medio-basal temporal lobe. Dipole tracing was very useful in localizing the dipole sources of interictal epileptiform activities and in understanding the neurophysiological background. PMID:15558875

  6. Active sand dunes are largest dust source in the Sahara Desert

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Atreyee

    2012-09-01

    Dried up lakebeds and playas in the Sahara Desert of North Africa are large sources of dust in the atmosphere. The Bodélé Depression at the southern edge of the Sahara Desert, for example, is the single largest source of dust in the world; on average, 100 dust storms a year originate from the Bodélé Depression. A new study by Crouvi et al., however, finds that active sand dunes could be even bigger sources of desert dust in the atmosphere. Atmospheric dust plays active roles in climate and biological processes in the ocean: It regulates heating at the surface of the Earth; modifies cloud properties that affect rainfall; and acts as the only source of iron, a critical nutrient for microorganisms in the ocean. Little is known about types of dust sources in the Sahara Desert, which alone accounts for more than 50% of the dust in the atmosphere.

  7. Use of active source geophones for passive source imaging: Examples from Bighorn Arch Seismic Experiment (BASE), USA

    NASA Astrophysics Data System (ADS)

    Sheehan, A.; O'rourke, C. T.; Haines, S. S.; Yang, Z.; Worthington, L. L.; Miller, K. C.

    2013-05-01

    In this paper we explore the variety of active and passive source deep seismic imaging that can be performed using continous wavefield recordings from a dense array of industry-style geophones. The data in this study were acquired during the 2009-10 EarthScope FlexArray Bighorn Arch Seismic Experiment(BASE) in central Wyoming, USA. In addition to traditional active and passive source seismic data acquisition, BASE included a deployment of 850 Reftek RT125 " Texan" dataloggers that produced continuous recording over 14 days. Ground motion was recorded via Geospace GS-11 4.5 Hz single channel vertical component geophones. The geophones were deployed in a grid of three E-W lines and two N-S lines across the Bighorn Mountains. We find that the high frequency geophones effectively record the P waves of teleseismic earthquakes. During the 15 days of continuous recording we observed 57 teleseismic events with pickable P-wave arrivals across the array, providing over 10,000 travel times (P, PKiKP, Pdiff, Pn) suitable for teleseismic tomography. The full waveforms can be used to extract additional information about the subsurface. We have successfully utilized teleseismic receiver-side crustal reverberation phases as virtual sources to mimic crustal reflection profiles (Yang et al., 2012). After depth conversion, we find a coherent phase that correlates well with the top of the Madison Formation under the Powder River and Bighorn Basins that flank the Bighorn Mountains. In addition, we combine the phases PpPdp from single-channel geophone recordings and Ps from three-component recordings to constrain the average Vp /Vs ratio for the sedimentary strata. Following Haines (2011), we are exploring the use of interferometric processing of active source blasts. In principle, virtual source and receiver gathers can be created through cross-correlation of full wavefields. The seismic interferometry provides a means of simulating alternative acquisition geometries, and has the

  8. Absolute instability of the Gaussian wake profile

    NASA Technical Reports Server (NTRS)

    Hultgren, Lennart S.; Aggarwal, Arun K.

    1987-01-01

    Linear parallel-flow stability theory has been used to investigate the effect of viscosity on the local absolute instability of a family of wake profiles with a Gaussian velocity distribution. The type of local instability, i.e., convective or absolute, is determined by the location of a branch-point singularity with zero group velocity of the complex dispersion relation for the instability waves. The effects of viscosity were found to be weak for values of the wake Reynolds number, based on the center-line velocity defect and the wake half-width, larger than about 400. Absolute instability occurs only for sufficiently large values of the center-line wake defect. The critical value of this parameter increases with decreasing wake Reynolds number, thereby indicating a shrinking region of absolute instability with decreasing wake Reynolds number. If backflow is not allowed, absolute instability does not occur for wake Reynolds numbers smaller than about 38.

  9. Agent-based power sharing scheme for active hybrid power sources

    NASA Astrophysics Data System (ADS)

    Jiang, Zhenhua

    The active hybridization technique provides an effective approach to combining the best properties of a heterogeneous set of power sources to achieve higher energy density, power density and fuel efficiency. Active hybrid power sources can be used to power hybrid electric vehicles with selected combinations of internal combustion engines, fuel cells, batteries, and/or supercapacitors. They can be deployed in all-electric ships to build a distributed electric power system. They can also be used in a bulk power system to construct an autonomous distributed energy system. An important aspect in designing an active hybrid power source is to find a suitable control strategy that can manage the active power sharing and take advantage of the inherent scalability and robustness benefits of the hybrid system. This paper presents an agent-based power sharing scheme for active hybrid power sources. To demonstrate the effectiveness of the proposed agent-based power sharing scheme, simulation studies are performed for a hybrid power source that can be used in a solar car as the main propulsion power module. Simulation results clearly indicate that the agent-based control framework is effective to coordinate the various energy sources and manage the power/voltage profiles.

  10. EEG and MEG: sensitivity to epileptic spike activity as function of source orientation and depth.

    PubMed

    Hunold, A; Funke, M E; Eichardt, R; Stenroos, M; Haueisen, J

    2016-07-01

    Simultaneous electroencephalography (EEG) and magnetoencephalography (MEG) recordings of neuronal activity from epileptic patients reveal situations in which either EEG or MEG or both modalities show visible interictal spikes. While different signal-to-noise ratios (SNRs) of the spikes in EEG and MEG have been reported, a quantitative relation of spike source orientation and depth as well as the background brain activity to the SNR has not been established. We investigated this quantitative relationship for both dipole and patch sources in an anatomically realistic cortex model. Altogether, 5600 dipole and 3300 patch sources were distributed on the segmented cortical surfaces of two volunteers. The sources were classified according to their quantified depths and orientations, ranging from 20 mm to 60 mm below the skin surface and radial and tangential, respectively. The source time-courses mimicked an interictal spike, and the simulated background activity emulated resting activity. Simulations were conducted with individual three-compartment boundary element models. The SNR was evaluated for 128 EEG, 102 MEG magnetometer, and 204 MEG gradiometer channels. For superficial dipole and superficial patch sources, EEG showed higher SNRs for dominantly radial orientations, and MEG showed higher values for dominantly tangential orientations. Gradiometers provided higher SNR than magnetometers for superficial sources, particularly for those with dominantly tangential orientations. The orientation dependent difference in SNR in EEG and MEG gradually changed as the sources were located deeper, where the interictal spikes generated higher SNRs in EEG compared to those in MEG for all source orientations. With deep sources, the SNRs in gradiometers and magnetometers were of the same order. To better detect spikes, both EEG and MEG should be used. PMID:27328313

  11. NSLS 2007 Activity Report (National Synchrotron Light Source Activity Report 2007)

    SciTech Connect

    Miller ,L.; Nasta, K.

    2008-05-01

    The National Synchrotron Light Source is one of the world's most productive and cost-effective user facilities. With 2,219 individual users, about 100 more than last year, and a record-high 985 publications, 2007 was no exception. In addition to producing an impressive array of science highlights, which are included in this Activity Report, many NSLS users were honored this year for their scientific accomplishments. Throughout the year, there were major strides in the development of the scientific programs by strengthening strategic partnerships with major research resources and with the Center for Functional Nanomaterials (CFN). Of particular note, the Consortium for Materials Properties Research in Earth Sciences (COMPRES) received renewed funding for the next five years through the National Science Foundation. COMPRES operates four high-pressure NSLS beamlines--X17B2, X17B3, X17C, and U2A--and serves the earth science community as well as the rapidly expanding segment of researchers using high-pressure techniques in materials, chemical, and energy-related sciences. A joint appointment was made between the NSLS and Stony Brook University to further enhance interactions with COMPRES. There was major progress on two key beamline projects outlined in the Five-Year Strategic Plan: the X25 beamline upgrade and the construction of the X9 small angle scattering (SAXS) beamline. The X25 overhaul, which began with the installation of the in-vacuum mini-gap undulator (MGU) in January 2006, is now complete. X25 is once again the brightest beamline for macromolecular crystallography at the NSLS, and in tandem with the X29 undulator beamline, it will keep the NSLS at the cutting edge in this important area of research. Upgrade work associated with the new MGU and the front end for the X9 SAXS beamline--jointly developed by the NSLS and the CFN--also was completed. Beamline X9 will host the SAXS program that currently exists at beamline X21 and will provide new microbeam SAXS

  12. THE ENVIRONMENT AND DISTRIBUTION OF EMITTING ELECTRONS AS A FUNCTION OF SOURCE ACTIVITY IN MARKARIAN 421

    SciTech Connect

    Mankuzhiyil, Nijil; Ansoldi, Stefano; Tavecchio, Fabrizio

    2011-05-20

    For the high-frequency-peaked BL Lac object Mrk 421, we study the variation of the spectral energy distribution (SED) as a function of source activity, from quiescent to active. We use a fully automatized {chi}{sup 2}-minimization procedure, instead of the 'eyeball' procedure more commonly used in the literature, to model nine SED data sets with a one-zone synchrotron self-Compton (SSC) model and examine how the model parameters vary with source activity. The latter issue can finally be addressed now, because simultaneous broadband SEDs (spanning from optical to very high energy photon) have finally become available. Our results suggest that in Mrk 421 the magnetic field (B) decreases with source activity, whereas the electron spectrum's break energy ({gamma}{sub br}) and the Doppler factor ({delta}) increase-the other SSC parameters turn out to be uncorrelated with source activity. In the SSC framework, these results are interpreted in a picture where the synchrotron power and peak frequency remain constant with varying source activity, through a combination of decreasing magnetic field and increasing number density of {gamma} {<=} {gamma}{sub br} electrons: since this leads to an increased electron-photon scattering efficiency, the resulting Compton power increases, and so does the total (= synchrotron plus Compton) emission.

  13. Absolute determination of local tropospheric OH concentrations

    NASA Technical Reports Server (NTRS)

    Armerding, Wolfgang; Comes, Franz-Josef

    1994-01-01

    Long path absorption (LPA) according to Lambert Beer's law is a method to determine absolute concentrations of trace gases such as tropospheric OH. We have developed a LPA instrument which is based on a rapid tuning of the light source which is a frequency doubled dye laser. The laser is tuned across two or three OH absorption features around 308 nm with a scanning speed of 0.07 cm(exp -1)/microsecond and a repetition rate of 1.3 kHz. This high scanning speed greatly reduces the fluctuation of the light intensity caused by the atmosphere. To obtain the required high sensitivity the laser output power is additionally made constant and stabilized by an electro-optical modulator. The present sensitivity is of the order of a few times 10(exp 5) OH per cm(exp 3) for an acquisition time of a minute and an absorption path length of only 1200 meters so that a folding of the optical path in a multireflection cell was possible leading to a lateral dimension of the cell of a few meters. This allows local measurements to be made. Tropospheric measurements have been carried out in 1991 resulting in the determination of OH diurnal variation at specific days in late summer. Comparison with model calculations have been made. Interferences are mainly due to SO2 absorption. The problem of OH self generation in the multireflection cell is of minor extent. This could be shown by using different experimental methods. The minimum-maximum signal to noise ratio is about 8 x 10(exp -4) for a single scan. Due to the small size of the absorption cell the realization of an open air laboratory is possible in which by use of an additional UV light source or by additional fluxes of trace gases the chemistry can be changed under controlled conditions allowing kinetic studies of tropospheric photochemistry to be made in open air.

  14. Hitting the target: relatively easy, yet absolutely difficult.

    PubMed

    Mapp, Alistair P; Ono, Hiroshi; Khokhotva, Mykola

    2007-01-01

    It is generally agreed that absolute-direction judgments require information about eye position, whereas relative-direction judgments do not. The source of this eye-position information, particularly during monocular viewing, is a matter of debate. It may be either binocular eye position, or the position of the viewing-eye only, that is crucial. Using more ecologically valid stimulus situations than the traditional LED in the dark, we performed two experiments. In experiment 1, observers threw darts at targets that were fixated either monocularly or binocularly. In experiment 2, observers aimed a laser gun at targets while fixating either the rear or the front gunsight monocularly, or the target either monocularly or binocularly. We measured the accuracy and precision of the observers' absolute- and relative-direction judgments. We found that (a) relative-direction judgments were precise and independent of phoria, and (b) monocular absolute-direction judgments were inaccurate, and the magnitude of the inaccuracy was predictable from the magnitude of phoria. These results confirm that relative-direction judgments do not require information about eye position. Moreover, they show that binocular eye-position information is crucial when judging the absolute direction of both monocular and binocular targets. PMID:17972479

  15. Absolute Radiometer for Reproducing the Solar Irradiance Unit

    NASA Astrophysics Data System (ADS)

    Sapritskii, V. I.; Pavlovich, M. N.

    1989-01-01

    A high-precision absolute radiometer with a thermally stabilized cavity as receiving element has been designed for use in solar irradiance measurements. The State Special Standard of the Solar Irradiance Unit has been built on the basis of the developed absolute radiometer. The Standard also includes the sun tracking system and the system for automatic thermal stabilization and information processing, comprising a built-in microcalculator which calculates the irradiance according to the input program. During metrological certification of the Standard, main error sources have been analysed and the non-excluded systematic and accidental errors of the irradiance-unit realization have been determined. The total error of the Standard does not exceed 0.3%. Beginning in 1984 the Standard has been taking part in a comparison with the Å 212 pyrheliometer and other Soviet and foreign standards. In 1986 it took part in the international comparison of absolute radiometers and standard pyrheliometers of socialist countries. The results of the comparisons proved the high metrological quality of this Standard based on an absolute radiometer.

  16. Activation analysis of indium, KCl, and melamine by using a laser-induced neutron source

    NASA Astrophysics Data System (ADS)

    Lee, Sungman; Lee, Kitae; Cha, Hyungki

    2014-04-01

    A laser-induced repetitively operated fast neutron source with a neutron yield of 4 × 105 n/pulse and a pulse repetition rate of 5 Hz, which was developed using a deuterated polystyrene film target and a 24-TW femtosecond laser, was applied for laser activation analyses of indium, KCl, and melamine samples. The nuclear reactions of the measured gamma spectra for the activated samples were identified as (n, γ), (n, n'), and (n, 2n) reactions. These indicate possible usage of the neutron source for practical activation analyses of various materials.

  17. Source activity correlation effects on LCMV beamformers in a realistic measurement environment.

    PubMed

    Belardinelli, Paolo; Ortiz, Erick; Braun, Christoph

    2012-01-01

    In EEG and MEG studies on brain functional connectivity and source interactions can be performed at sensor or source level. Beamformers are well-established source-localization tools for MEG/EEG signals, being employed in source connectivity studies both in time and frequency domain. However, it has been demonstrated that beamformers suffer from a localization bias due to correlation between source time courses. This phenomenon has been ascertained by means of theoretical proofs and simulations. Nonetheless, the impact of correlated sources on localization outputs with real data has been disputed for a long time. In this paper, by means of a phantom, we address the correlation issue in a realistic MEG environment. Localization performances in the presence of simultaneously active sources are studied as a function of correlation degree and distance between sources. A linear constrained minimum variance (LCMV) beamformer is applied to the oscillating signals generated by the current dipoles within the phantom. Results show that high correlation affects mostly dipoles placed at small distances (1, 5 centimeters). In this case the sources merge. If the dipoles lie 3 centimeters apart, the beamformer localization detects attenuated power amplitudes and blurred sources as the correlation level raises. PMID:22611439

  18. NSLS 2005 ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 2005).

    SciTech Connect

    MILLER, L.

    2006-05-01

    In 2005, the NSLS proved itself, once again, to be a center of scientific excellence. This remarkable facility, commissioned in the early 1980s, is still attracting some of the world's best researchers in almost every scientific field, who produce more than seven hundred scientific papers every year using the NSLS. The 'Science Highlights' and 'Feature Highlights' sections of this report are just a small sampling of the many, many impressive research projects conducted at the NSLS in 2005. For example, a user group synthesized and studied zinc-oxide nanowires, which have applications in many optical and electrical devices. Another user group studied how strontium and uranium are removed from high-level radioactive waste. And in another interesting study, users deciphered the basis for antibiotic resistance. However, as always, the success of these projects depends on the performance of the facility. Again this year, the rings were in top form--reliability was 96 percent for the x-ray ring and 99 percent for the VUV-IR ring. Additionally, to keep the NSLS as productive as possible and to continue to attract users, many beamline upgrade projects were completed this year. One of the highlights of these upgrades is the new mini-gap undulator installed at beamline X25. This insertion device is providing a much brighter x-ray source for the program at X25. In the always important area of safety, several noteworthy activities took place this year. In particular, NSLS staff made a major commitment to labeling and inspecting electrical equipment. And perhaps the best news is what didn't happen--there were no reportable occurrences related to environmental, safety, or health issues in 2005, and no injuries that resulted in restricted or lost time. We all owe thanks to the dedicated NSLS staff and users who have ensured that the NSLS remains a reliable, safe, up-to-date research facility. As 2005 came to an end, I stepped down as NSLS Chairman in order to focus my primary

  19. Imaging the magmatic system of Newberry Volcano using Joint active source and teleseismic tomography

    NASA Astrophysics Data System (ADS)

    Heath, Benjamin A.; Hooft, Emilie E. E.; Toomey, Douglas R.; Bezada, Maximiliano J.

    2015-12-01

    In this paper, we combine active and passive source P wave seismic data to tomographically image the magmatic system beneath Newberry Volcano, located east of the Cascade arc. By using both travel times from local active sources and delay times from teleseismic earthquakes recorded on closely spaced seismometers (300-800 m), we significantly improve recovery of upper crustal velocity structure (<10 km depth). The tomographic model reveals a low-velocity feature between 3 and 5 km depth that lies beneath the caldera, consistent with a magma body. In contrast to earlier tomographic studies, where elevated temperatures were sufficient to explain the recovered low velocities, the larger amplitude low-velocity anomalies in our joint tomography model require low degrees of partial melt (˜10%), and a minimum melt volume of ˜2.5 km3. Furthermore, synthetic tests suggest that even greater magnitude low-velocity anomalies, and by inference larger volumes of magma (up to 8 km3), are needed to explain the observed waveform variability. The lateral extent and shape of the inferred magma body indicates that the extensional tectonic regime at Newberry influences the emplacement of magmatic intrusions. Our study shows that jointly inverting active source and passive source seismic data improves tomographic imaging of the shallow crustal seismic structure of volcanic systems and that active source experiments would benefit from longer deployment times to also record teleseismic sources.

  20. Absolute optical instruments without spherical symmetry

    NASA Astrophysics Data System (ADS)

    Tyc, Tomáš; Dao, H. L.; Danner, Aaron J.

    2015-11-01

    Until now, the known set of absolute optical instruments has been limited to those containing high levels of symmetry. Here, we demonstrate a method of mathematically constructing refractive index profiles that result in asymmetric absolute optical instruments. The method is based on the analogy between geometrical optics and classical mechanics and employs Lagrangians that separate in Cartesian coordinates. In addition, our method can be used to construct the index profiles of most previously known absolute optical instruments, as well as infinitely many different ones.

  1. The MEG topography and the source model of abnormal neural activities associated with brain lesions

    SciTech Connect

    Ueno, S.; Iramina, K.; Ozaki, H.; Harada, K.

    1986-09-01

    A source model is proposed to simulate spatial distributions of abnormal MEG and EEG activities generated by abnormal neural activities such as the delta activity associated with brain tumors. Brain tumor itself is electrically silent and the spherical shell around the tumor might generate abnormal neural activities. The sources of these neural activities are represented by combinations of multiple current dipoles. The head is assumed to be a spherical volume conductor. Electrical potentials and magnetic fields over the surface of the spheres are calculated. The computer simulation shows that the MEG topography and EEG topography vary variously with combinations of location and orientation of the dipoles. In a special case, however, that the dipoles orient in the same direction or orient radially, the spatial patterns of the MEGs and EEGs generated by numerous dipoles are analogous to those generated by single dipoles.

  2. Measurement of the activity of an artificial neutrino source based on {sup 37}Ar

    SciTech Connect

    Abdurashitov, D. N.; Veretenkin, E. P.; Gavrin, V. N.; Gorbachev, V. V.; Ibragimova, T. V.; Kalikhov, A. V.; Mirmov, I. N. Shikhin, A. A.; Yants, V. E.; Barsanov, V. I.; Dzhanelidze, A. A.; Zlokazov, S. B.; Markov, S. Yu.; Shakirov, Z. N.; Cleveland, B. T.

    2007-02-15

    The activity of an artificial neutrino source based on {sup 37}Ar was measured by a specially developed method of directly counting {sup 37}Ar decays in a proportional counter. This source was used to irradiate the target of the SAGE radiochemical gallium-germanium neutrino telescope at the Baksan Neutrino Observatory (Institute for Nuclear Research, Russian Academy of Sciences, Moscow), whereupon the measurements were performed at the Institute of Reactor Materials (Zarechny, Sverdlovsk oblast, Russia). The method used to prepare gaseous samples for measurements in proportional counters and the counting procedure are described. The measured activity of the {sup 37}Ar neutrino source is 405.1 {+-} 3.7 kCi (corrected for decays that occurred within the period between the instant of activity measurement and the commencement of the irradiation of Ga target at 04:00 Moscow time, 30.04.2004)

  3. A laser-induced repetitive fast neutron source applied for gold activation analysis

    NASA Astrophysics Data System (ADS)

    Lee, Sungman; Park, Sangsoon; Lee, Kitae; Cha, Hyungki

    2012-12-01

    A laser-induced repetitively operated fast neutron source was developed for applications in laser-driven nuclear physics research. The developed neutron source, which has a neutron yield of approximately 4 × 105 n/pulse and can be operated up to a pulse repetition rate of 10 Hz, was applied for a gold activation analysis. Relatively strong delayed gamma spectra of the activated gold were measured at 333 keV and 355 keV, and proved the possibility of the neutron source for activation analyses. In addition, the nuclear reactions responsible for the measured gamma spectra of gold were elucidated by the 14 MeV fast neutrons resulting from the D(t,n)He4 nuclear reaction, for which the required tritium originated from the primary fusion reaction, D(d,p)T3.

  4. A laser-induced repetitive fast neutron source applied for gold activation analysis

    SciTech Connect

    Lee, Sungman; Park, Sangsoon; Lee, Kitae; Cha, Hyungki

    2012-12-15

    A laser-induced repetitively operated fast neutron source was developed for applications in laser-driven nuclear physics research. The developed neutron source, which has a neutron yield of approximately 4 Multiplication-Sign 10{sup 5} n/pulse and can be operated up to a pulse repetition rate of 10 Hz, was applied for a gold activation analysis. Relatively strong delayed gamma spectra of the activated gold were measured at 333 keV and 355 keV, and proved the possibility of the neutron source for activation analyses. In addition, the nuclear reactions responsible for the measured gamma spectra of gold were elucidated by the 14 MeV fast neutrons resulting from the D(t,n)He{sup 4} nuclear reaction, for which the required tritium originated from the primary fusion reaction, D(d,p)T{sup 3}.

  5. A laser-induced repetitive fast neutron source applied for gold activation analysis.

    PubMed

    Lee, Sungman; Park, Sangsoon; Lee, Kitae; Cha, Hyungki

    2012-12-01

    A laser-induced repetitively operated fast neutron source was developed for applications in laser-driven nuclear physics research. The developed neutron source, which has a neutron yield of approximately 4 × 10(5) n/pulse and can be operated up to a pulse repetition rate of 10 Hz, was applied for a gold activation analysis. Relatively strong delayed gamma spectra of the activated gold were measured at 333 keV and 355 keV, and proved the possibility of the neutron source for activation analyses. In addition, the nuclear reactions responsible for the measured gamma spectra of gold were elucidated by the 14 MeV fast neutrons resulting from the D(t,n)He(4) nuclear reaction, for which the required tritium originated from the primary fusion reaction, D(d,p)T(3). PMID:23277984

  6. Evidence for Infrared-faint Radio Sources as z > 1 Radio-loud Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Huynh, Minh T.; Norris, Ray P.; Siana, Brian; Middelberg, Enno

    2010-02-01

    Infrared-Faint Radio Sources (IFRSs) are a class of radio objects found in the Australia Telescope Large Area Survey which have no observable mid-infrared counterpart in the Spitzer Wide-area Infrared Extragalactic (SWIRE) survey. The extended Chandra Deep Field South now has even deeper Spitzer imaging (3.6-70 μm) from a number of Legacy surveys. We report the detections of two IFRS sources in IRAC images. The non-detection of two other IFRSs allows us to constrain the source type. Detailed modeling of the spectral energy distribution of these objects shows that they are consistent with high-redshift (z >~ 1) active galactic nuclei.

  7. Absolute magnitudes of trans-neptunian objects

    NASA Astrophysics Data System (ADS)

    Duffard, R.; Alvarez-candal, A.; Pinilla-Alonso, N.; Ortiz, J. L.; Morales, N.; Santos-Sanz, P.; Thirouin, A.

    2015-10-01

    Accurate measurements of diameters of trans- Neptunian objects are extremely complicated to obtain. Radiomatric techniques applied to thermal measurements can provide good results, but precise absolute magnitudes are needed to constrain diameters and albedos. Our objective is to measure accurate absolute magnitudes for a sample of trans- Neptunian objects, many of which have been observed, and modelled, by the "TNOs are cool" team, one of Herschel Space Observatory key projects grantes with ~ 400 hours of observing time. We observed 56 objects in filters V and R, if possible. These data, along with data available in the literature, was used to obtain phase curves and to measure absolute magnitudes by assuming a linear trend of the phase curves and considering magnitude variability due to rotational light-curve. In total we obtained 234 new magnitudes for the 56 objects, 6 of them with no reported previous measurements. Including the data from the literature we report a total of 109 absolute magnitudes.

  8. A New Gimmick for Assigning Absolute Configuration.

    ERIC Educational Resources Information Center

    Ayorinde, F. O.

    1983-01-01

    A five-step procedure is provided to help students in making the assignment absolute configuration less bothersome. Examples for both single (2-butanol) and multi-chiral carbon (3-chloro-2-butanol) molecules are included. (JN)

  9. Active control of noise on the source side of a partition to increase its sound isolation

    NASA Astrophysics Data System (ADS)

    Tarabini, Marco; Roure, Alain; Pinhede, Cedric

    2009-03-01

    This paper describes a local active noise control system that virtually increases the sound isolation of a dividing wall by means of a secondary source array. With the proposed method, sound pressure on the source side of the partition is reduced using an array of loudspeakers that generates destructive interference on the wall surface, where an array of error microphones is placed. The reduction of sound pressure on the incident side of the wall is expected to decrease the sound radiated into the contiguous room. The method efficiency was experimentally verified by checking the insertion loss of the active noise control system; in order to investigate the possibility of using a large number of actuators, a decentralized FXLMS control algorithm was used. Active control performances and stability were tested with different array configurations, loudspeaker directivities and enclosure characteristics (sound source position and absorption coefficient). The influence of all these parameters was investigated with the factorial design of experiments. The main outcome of the experimental campaign was that the insertion loss produced by the secondary source array, in the 50-300 Hz frequency range, was close to 10 dB. In addition, the analysis of variance showed that the active noise control performance can be optimized with a proper choice of the directional characteristics of the secondary source and the distance between loudspeakers and error microphones.

  10. Three-dimensional localization of low activity gamma-ray sources in real-time scenarios

    NASA Astrophysics Data System (ADS)

    Sharma, Manish K.; Alajo, Ayodeji B.; Lee, Hyoung K.

    2016-03-01

    Radioactive source localization plays an important role in tracking radiation threats in homeland security tasks. Its real-time application requires computationally efficient and reasonably accurate algorithms even with limited data to support detection with minimum uncertainty. This paper describes a statistic-based grid-refinement method for backtracing the position of a gamma-ray source in a three-dimensional domain in real-time. The developed algorithm used measurements from various known detector positions to localize the source. This algorithm is based on an inverse-square relationship between source intensity at a detector and the distance from the source to the detector. The domain discretization was developed and implemented in MATLAB. The algorithm was tested and verified from simulation results of an ideal case of a point source in non-attenuating medium. Subsequently, an experimental validation of the algorithm was performed to determine the suitability of deploying this scheme in real-time scenarios. Using the measurements from five known detector positions and for a measurement time of 3 min, the source position was estimated with an accuracy of approximately 53 cm. The accuracy improved and stabilized to approximately 25 cm for higher measurement times. It was concluded that the error in source localization was primarily due to detection uncertainties. In verification and experimental validation of the algorithm, the distance between 137Cs source and any detector position was between 0.84 m and 1.77 m. The results were also compared with the least squares method. Since the discretization algorithm was validated with a weak source, it is expected that it can localize the source of higher activity in real-time. It is believed that for the same physical placement of source and detectors, a source of approximate activity 0.61-0.92 mCi can be localized in real-time with 1 s of measurement time and same accuracy. The accuracy and computational efficiency

  11. Henry More and the development of absolute time.

    PubMed

    Thomas, Emily

    2015-12-01

    This paper explores the nature, development and influence of the first English account of absolute time, put forward in the mid-seventeenth century by the 'Cambridge Platonist' Henry More. Against claims in the literature that More does not have an account of time, this paper sets out More's evolving account and shows that it reveals the lasting influence of Plotinus. Further, this paper argues that More developed his views on time in response to his adoption of Descartes' vortex cosmology and cosmogony, providing new evidence of More's wider project to absorb Cartesian natural philosophy into his Platonic metaphysics. Finally, this paper argues that More should be added to the list of sources that later English thinkers - including Newton and Samuel Clarke - drew on in constructing their absolute accounts of time. PMID:26568082

  12. Absolute Configurations of Zingiberenols Isolated from Ginger (Zingiber officinale) Rhizomes.

    PubMed

    Khrimian, Ashot; Shirali, Shyam; Guzman, Filadelfo

    2015-12-24

    Two stereoisomeric zingiberenols in ginger were identified as (3R,6R,7S)-1,10-bisaboladien-3-ol (2) and (3S,6R,7S)-1,10-bisaboladien-3-ol (5). Absolute configurations were assigned by utilizing 1,10-bisaboladien-3-ol stereoisomers and two gas-chromatography columns: a 25 m Hydrodex-β-6TBDM and 60 m DB-5MS. The C-6 and C-7 absolute configurations in both zingiberenols match those of zingiberene present abundantly in ginger rhizomes. Interestingly, zingiberenol 2 has recently been identified as a male-produced sex pheromone of the rice stink bug, Oebalus poecilus, thus indicating that ginger plants may be a potential source of the sex pheromone of this bug. PMID:26606508

  13. Absolute charge calibration of scintillating screens for relativistic electron detection

    SciTech Connect

    Buck, A.; Popp, A.; Schmid, K.; Karsch, S.; Krausz, F.; Zeil, K.; Jochmann, A.; Kraft, S. D.; Sauerbrey, R.; Cowan, T.; Schramm, U.; Hidding, B.; Kudyakov, T.; Sears, C. M. S.; Veisz, L.; Pawelke, J.

    2010-03-15

    We report on new charge calibrations and linearity tests with high-dynamic range for eight different scintillating screens typically used for the detection of relativistic electrons from laser-plasma based acceleration schemes. The absolute charge calibration was done with picosecond electron bunches at the ELBE linear accelerator in Dresden. The lower detection limit in our setup for the most sensitive scintillating screen (KODAK Biomax MS) was 10 fC/mm{sup 2}. The screens showed a linear photon-to-charge dependency over several orders of magnitude. An onset of saturation effects starting around 10-100 pC/mm{sup 2} was found for some of the screens. Additionally, a constant light source was employed as a luminosity reference to simplify the transfer of a one-time absolute calibration to different experimental setups.

  14. Absolute calibration for a broad range single shot electron spectrometer

    SciTech Connect

    Glinec, Y.; Faure, J.; Guemnie-Tafo, A.; Malka, V.; Monard, H.; Larbre, J. P.; De Waele, V.; Marignier, J. L.; Mostafavi, M.

    2006-10-15

    This article gives a detailed description of a single shot electron spectrometer which was used to characterize electron beams produced by laser-plasma interaction. Contrary to conventional electron sources, electron beams from laser-plasma accelerators can produce a broad range of energies. Therefore, diagnosing these electron spectra requires specific attention and experimental development. Here, we provide an absolute calibration of the Lanex Kodak Fine screen on a laser-triggered radio frequency picosecond electron accelerator. The efficiency of scintillating screens irradiated by electron beams has never been investigated so far. This absolute calibration is then compared to charge measurements from an integrating current transformer for quasimonoenergetic electron spectra from laser-plasma interaction.

  15. Absolute charge calibration of scintillating screens for relativistic electron detection

    NASA Astrophysics Data System (ADS)

    Buck, A.; Zeil, K.; Popp, A.; Schmid, K.; Jochmann, A.; Kraft, S. D.; Hidding, B.; Kudyakov, T.; Sears, C. M. S.; Veisz, L.; Karsch, S.; Pawelke, J.; Sauerbrey, R.; Cowan, T.; Krausz, F.; Schramm, U.

    2010-03-01

    We report on new charge calibrations and linearity tests with high-dynamic range for eight different scintillating screens typically used for the detection of relativistic electrons from laser-plasma based acceleration schemes. The absolute charge calibration was done with picosecond electron bunches at the ELBE linear accelerator in Dresden. The lower detection limit in our setup for the most sensitive scintillating screen (KODAK Biomax MS) was 10 fC/mm2. The screens showed a linear photon-to-charge dependency over several orders of magnitude. An onset of saturation effects starting around 10-100 pC/mm2 was found for some of the screens. Additionally, a constant light source was employed as a luminosity reference to simplify the transfer of a one-time absolute calibration to different experimental setups.

  16. Absolute calibration for a broad range single shot electron spectrometer

    NASA Astrophysics Data System (ADS)

    Glinec, Y.; Faure, J.; Guemnie-Tafo, A.; Malka, V.; Monard, H.; Larbre, J. P.; De Waele, V.; Marignier, J. L.; Mostafavi, M.

    2006-10-01

    This article gives a detailed description of a single shot electron spectrometer which was used to characterize electron beams produced by laser-plasma interaction. Contrary to conventional electron sources, electron beams from laser-plasma accelerators can produce a broad range of energies. Therefore, diagnosing these electron spectra requires specific attention and experimental development. Here, we provide an absolute calibration of the Lanex Kodak Fine screen on a laser-triggered radio frequency picosecond electron accelerator. The efficiency of scintillating screens irradiated by electron beams has never been investigated so far. This absolute calibration is then compared to charge measurements from an integrating current transformer for quasimonoenergetic electron spectra from laser-plasma interaction.

  17. Orion Absolute Navigation System Progress and Challenge

    NASA Technical Reports Server (NTRS)

    Holt, Greg N.; D'Souza, Christopher

    2012-01-01

    The absolute navigation design of NASA's Orion vehicle is described. It has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary onboard measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudo-range and delta-range, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, and cold start are discussed as are strategies for whole and partial state updates as well as covariance considerations. Strategies are given for dealing with latent measurements and high-rate propagation using multi-rate architecture. The details of the rate groups and the data ow between the elements is discussed and evaluated.

  18. Active Control of a Moving Noise SOURCE—EFFECT of Off-Axis Source Position

    NASA Astrophysics Data System (ADS)

    GUO, J.; PAN, J.; HODGSON, M.

    2002-03-01

    An optimally arranged multiple-channel active-control system is known to be able to create a large quiet zone in free space for a stationary primary noise source. When the primary noise source moves, the active control of the noise becomes much more difficult, as the primary noise field changes with time in space. In this case, the controller of the control system must respond fast enough to compensate for the change; much research has been focused on this issue. In this paper, it is shown that a moving source also causes difficulties from an acoustical perspective. A moving source not only changes continuously the strengths and phases of the sound field in the space, but also changes the wavefront of the primary sound field continuously. It is known that the efficiency of active noise control is determined mainly by the wavefront matching between the primary and control fields. To keep the control system effective in the case of a moving source, the wavefront of the control field needs to change, in order to continuously match the primary-wavefront change. This paper shows that there are limitations to the control-wavefront change. An optimally pre-arranged, multiple-channel control system is not able to construct a matching wavefront when the primary source moves outside a certain range. In other words, the control system is still able to create a large quiet zone only when the primary source moves within a range around the central axis of the control system. Both the location and the size of the quiet zone change with the location of the primary source.

  19. Complex active regions as the main source of extreme and large solar proton events

    NASA Astrophysics Data System (ADS)

    Ishkov, V. N.

    2013-12-01

    A study of solar proton sources indicated that solar flare events responsible for ≥2000 pfu proton fluxes mostly occur in complex active regions (CARs), i.e., in transition structures between active regions and activity complexes. Different classes of similar structures and their relation to solar proton events (SPEs) and evolution, depending on the origination conditions, are considered. Arguments in favor of the fact that sunspot groups with extreme dimensions are CARs are presented. An analysis of the flare activity in a CAR resulted in the detection of "physical" boundaries, which separate magnetic structures of the same polarity and are responsible for the independent development of each structure.

  20. Studies on the nitrate reductase activities of the fruit and the source leaf in pepper

    SciTech Connect

    Achhireddy, N.R.; Beevers, L.; Fletcher, J.S.

    1983-12-01

    Nitrate reductase (NR) activity (NO/sub 2//sup -/ produced in the dark and under anaerobic conditions) of 30-day-old fruit of Capsicum annuum L. was 2.2% that in tissues of a single leaf adjacent to each fruit (33 vs. 1500 nmoles/hr-g fresh weight). The optimal NR activity in one source leaf could only account for about 17% of the fruit's total nitrogen accumulation, while the fruit's own NR activity was almost negligible. Covered and uncovered fruits did not differ significantly in NR activities. 19 references, 1 figure, 1 table.

  1. New light sources and sensors for active optical 3D inspection

    NASA Astrophysics Data System (ADS)

    Osten, Wolfgang; Jueptner, Werner P. O.

    1999-11-01

    The implementation of active processing strategies in optical 3D-inspection needs the availability of flexible hardware solutions. The system components illumination and sensor/detector are actively involved in the processing chain by a feedback loop that is controlled by the evaluation process. Therefore this article deals with new light sources and sensor which appeared recently on the market and can be applied successfully for the implementation of active processing principles. Some applications where such new components are used to implement an active measurement strategy are presented.

  2. Sources and magnitude of variability in pedometer-determined physical activity levels of youth

    PubMed Central

    Kim, So-Yeun; Park, Hye-Sang

    2015-01-01

    This study examined sources of variability in habitual physical activity of children, and the minimum number of days required for estimating children’s habitual physical activity levels using pedometers. A total of 31 children wore two pedometers during five weekdays and four weekend days. A two random facet completely crossed design was conducted with two-way analysis of variances across weekdays, weekends, and weekdays and weekend days combined. Moderate/high generalizability coefficients were estimated across all days. Primary sources of variability were variance components of the person and person by day interaction. Minimum numbers of days required for estimating habitual physical activity levels using a pedometer were five during weekdays. However, estimating habitual physical activity levels during weekends, and weekdays and weekend days combined was impractical. PMID:26730388

  3. Activation process in excitable systems with multiple noise sources: One and two interacting units.

    PubMed

    Franović, Igor; Todorović, Kristina; Perc, Matjaž; Vasović, Nebojša; Burić, Nikola

    2015-12-01

    We consider the coaction of two distinct noise sources on the activation process of a single excitable unit and two interacting excitable units, which are mathematically described by the Fitzhugh-Nagumo equations. We determine the most probable activation paths around which the corresponding stochastic trajectories are clustered. The key point lies in introducing appropriate boundary conditions that are relevant for a class II excitable unit, which can be immediately generalized also to scenarios involving two coupled units. We analyze the effects of the two noise sources on the statistical features of the activation process, in particular demonstrating how these are modified due to the linear or nonlinear form of interactions. Universal properties of the activation process are qualitatively discussed in the light of a stochastic bifurcation that underlies the transition from a stochastically stable fixed point to continuous oscillations. PMID:26764778

  4. Influence of source composition and particle energy on the determination of gross alpha activity.

    PubMed

    Timón, A Fernández; Vargas, M Jurado; Sánchez, A B Ruano; Pérez, J de la Torre; Sánchez, A Martín

    2013-12-01

    The influence of different source compositions and α-particle energies on the detection efficiency of a gas-flow proportional counter was examined using experimental measurements and Monte Carlo simulations. Efficiency variation with alpha-particle energy was very marked, being less significant with the substrate composition. These results show that the determination of gross alpha activity in an unknown sample must be carried out very carefully in order to give a correct estimation of its activity. PMID:24184741

  5. Advanced Control Strategy for Single-Phase Voltage-Source Active Rectifier with Low Harmonic Emission

    NASA Astrophysics Data System (ADS)

    Blahník, Vojtĕch; Peroutka, Zdenĕk; Talla, Jakub

    2014-03-01

    This paper introduces the advanced control of single-phase voltage-source active rectifier. This control provide direct control of trolley-wire current and active damping of low-frequency disturbances at the converter ac side. Our proposed control strategy combines PR controller with feed-forward model and low-frequency harmonic compensator based on resonant controllers. Achieved experimental results show excellent converter behavior, where converter is fed by strongly distorted supply voltage.

  6. Efficient localization of synchronous EEG source activities using a modified RAP-MUSIC algorithm.

    PubMed

    Liu, Hesheng; Schimpf, Paul H

    2006-04-01

    Synchronization across different brain regions is suggested to be a possible mechanism for functional integration. Noninvasive analysis of the synchronization among cortical areas is possible if the electrical sources can be estimated by solving the electroencephalography inverse problem. Among various inverse algorithms, spatio-temporal dipole fitting methods such as RAP-MUSIC and R-MUSIC have demonstrated superior ability in the localization of a restricted number of independent sources, and also have the ability to reliably reproduce temporal waveforms. However, these algorithms experience difficulty in reconstructing multiple correlated sources. Accurate reconstruction of correlated brain activities is critical in synchronization analysis. In this study, we modified the well-known inverse algorithm RAP-MUSIC to a multistage process which analyzes the correlation of candidate sources and searches for independent topographies (ITs) among precorrelated groups. Comparative studies were carried out on both simulated data and clinical seizure data. The results demonstrated superior performance with the modified algorithm compared to the original RAP-MUSIC in recovering synchronous sources and localizing the epileptiform activity. The modified RAP-MUSIC algorithm, thus, has potential in neurological applications involving significant synchronous brain activities. PMID:16602571

  7. ALLStars: Overcoming Multi-Survey Selection Bias using Crowd-Sourced Active Learning

    NASA Astrophysics Data System (ADS)

    Starr, D. L.; Richards, J. W.; Brink, H.; Miller, A. A.; Bloom, J. S.; Butler, N. R.; James, J. B.; Long, J. P.

    2012-09-01

    Developing a multi-survey time-series classifier presents several challenges. One problem is overcoming the sample selection bias which arises when the instruments or observing cadences differ between the training and testing datasets. In this case, the probabilistic distributions characterizing the sources in the training survey dataset differ from the source distributions in the other survey, resulting in poor results when a classifier is naively applied. To resolve this, we have developed the ALLStars active learning framework which allows us to bootstrap a classifier onto a new survey using a small set of optimally chosen sources which are then presented to users for manual classification. Several iterations of this crowd-sourcing process results in a significantly improved classifier. Using this procedure, we have built a variable star light-curve classifier using OGLE, Hipparcos, and ASAS survey data.

  8. Promoting Conceptual Change through Active Learning Using Open Source Software for Physics Simulations

    ERIC Educational Resources Information Center

    Baser, Mustafa

    2006-01-01

    This paper reports upon an active learning approach that promotes conceptual change when studying direct current electricity circuits, using free open source software, "Qucs". The study involved a total of 102 prospective mathematics teacher students. Prior to instruction, students' understanding of direct current electricity was determined by a…

  9. The Main Sources of Intersubject Variability in Neuronal Activation for Reading Aloud

    ERIC Educational Resources Information Center

    Kherif, Ferath; Josse, Goulven; Seghier, Mohamed L.; Price, Cathy J.

    2009-01-01

    The aim of this study was to find the most prominent source of intersubject variability in neuronal activation for reading familiar words aloud. To this end, we collected functional imaging data from a large sample of subjects (n = 76) with different demographic characteristics such as handedness, sex, and age, while reading. The…

  10. 1994 Activity Report, National Synchrotron Light Source. Annual report, October 1, 1993-September 30, 1994

    SciTech Connect

    Rothman, E.Z.

    1995-05-01

    This report is a summary of activities carried out at the National Synchrotron Light Source during 1994. It consists of sections which summarize the work carried out in differing scientific disciplines, meetings and workshops, operations experience of the facility, projects undertaken for upgrades, administrative reports, and collections of abstracts and publications generated from work done at the facility.

  11. Jasminum flexile flower absolute from India--a detailed comparison with three other jasmine absolutes.

    PubMed

    Braun, Norbert A; Kohlenberg, Birgit; Sim, Sherina; Meier, Manfred; Hammerschmidt, Franz-Josef

    2009-09-01

    Jasminum flexile flower absolute from the south of India and the corresponding vacuum headspace (VHS) sample of the absolute were analyzed using GC and GC-MS. Three other commercially available Indian jasmine absolutes from the species: J. sambac, J. officinale subsp. grandiflorum, and J. auriculatum and the respective VHS samples were used for comparison purposes. One hundred and twenty-one compounds were characterized in J. flexile flower absolute, with methyl linolate, benzyl salicylate, benzyl benzoate, (2E,6E)-farnesol, and benzyl acetate as the main constituents. A detailed olfactory evaluation was also performed. PMID:19831037

  12. Accumulated source imaging of brain activity with both low and high-frequency neuromagnetic signals

    PubMed Central

    Xiang, Jing; Luo, Qian; Kotecha, Rupesh; Korman, Abraham; Zhang, Fawen; Luo, Huan; Fujiwara, Hisako; Hemasilpin, Nat; Rose, Douglas F.

    2014-01-01

    Recent studies have revealed the importance of high-frequency brain signals (>70 Hz). One challenge of high-frequency signal analysis is that the size of time-frequency representation of high-frequency brain signals could be larger than 1 terabytes (TB), which is beyond the upper limits of a typical computer workstation's memory (<196 GB). The aim of the present study is to develop a new method to provide greater sensitivity in detecting high-frequency magnetoencephalography (MEG) signals in a single automated and versatile interface, rather than the more traditional, time-intensive visual inspection methods, which may take up to several days. To address the aim, we developed a new method, accumulated source imaging, defined as the volumetric summation of source activity over a period of time. This method analyzes signals in both low- (1~70 Hz) and high-frequency (70~200 Hz) ranges at source levels. To extract meaningful information from MEG signals at sensor space, the signals were decomposed to channel-cross-channel matrix (CxC) representing the spatiotemporal patterns of every possible sensor-pair. A new algorithm was developed and tested by calculating the optimal CxC and source location-orientation weights for volumetric source imaging, thereby minimizing multi-source interference and reducing computational cost. The new method was implemented in C/C++ and tested with MEG data recorded from clinical epilepsy patients. The results of experimental data demonstrated that accumulated source imaging could effectively summarize and visualize MEG recordings within 12.7 h by using approximately 10 GB of computer memory. In contrast to the conventional method of visually identifying multi-frequency epileptic activities that traditionally took 2–3 days and used 1–2 TB storage, the new approach can quantify epileptic abnormalities in both low- and high-frequency ranges at source levels, using much less time and computer memory. PMID:24904402

  13. Four Years of Absolute Gravity in the Taiwan Orogen (AGTO)

    NASA Astrophysics Data System (ADS)

    Mouyen, Maxime; Masson, Frédéric; Hwang, Cheinway; Cheng, Ching-Chung; Le Moigne, Nicolas; Lee, Chiung-Wu; Kao, Ricky; Hsieh, Nicky

    2010-05-01

    AGTO is a scientific project between Taiwanese and French institutes, which aim is to improve tectonic knowledge of Taiwan primarily using absolute gravity measurements and permanent GPS stations. Both tools are indeed useful to study vertical movements and mass transfers involved in mountain building, a major process in Taiwan located at the convergent margin between Philippine Sea plate and Eurasian plate. This convergence results in two subductions north and south of Taiwan (Ryukyu and Manilla trenches, respectively), while the center is experiencing collision. These processes make Taiwan very active tectonically, as illustrated by numerous large earthquakes and rapid uplift of the Central Range. High slopes of Taiwan mountains and heavy rains brought by typhoons together lead to high landslides and mudflows risks. Practically, absolute gravity measurements have been yearly repeated since 2006 along a transect across south Taiwan, from Penghu to Lutao islands, using FG5 absolute gravimeters. This transect contains ten sites for absolute measurements and has been densified in 2008 by incorporating 45 sites for relative gravity measurements with CG5 gravimeters. The last relative and absolute measurements have been performed in November 2009. Most of the absolute sites have been measured with a good accuracy, about 1 or 2 ?Gal. Only the site located in Tainan University has higher standard deviation, due to the city noise. We note that absolute gravity changes seem to follow a trend in every site. However, straightforward tectonic interpretation of these trends is not valuable as many non-tectonic effects are supposed to change g with time, like groundwater or erosion. Estimating and removing these effects leads to a tectonic gravity signal, which has theoretically two origins : deep mass transfers around the site and vertical movements of the station. The latter can be well constrained by permanent GPS stations located close to the measurement pillar. Deep mass

  14. Four Years of Absolute Gravity in the Taiwan Orogen (AGTO)

    NASA Astrophysics Data System (ADS)

    Mouyen, M.; Masson, F.; Hwang, C.; Cheng, C.; Le Moigne, N.; Lee, C.; Kao, R.; Hsieh, N.

    2009-12-01

    AGTO is a scientific project between Taiwanese and French institutes which aim is to improve tectonic knowledge of Taiwan primarily using absolute gravity measurements and permanent GPS stations. Both tools are indeed useful to study vertical movements and mass transfers involved in mountain building, a major process in Taiwan located at the convergent margin between Philippine Sea plate and Eurasian plate. This convergence results in two subductions north and south of Taiwan (Ryukyu and Manilla trenches, respectively), while the center is experiencing collision. These processes make Taiwan very active tectonically, as illustrated by numerous large earthquakes and rapid uplift of the Central Range. High slopes of Taiwan mountains and heavy rains brought by typhoons together lead to high landslides and mudflows risks. Practically, absolute gravity measurements have been yearly repeated since 2006 along a transect across south Taiwan, from Penghu to Lutao island, using FG5 absolute gravimeters. This transect contains ten sites for absolute measurements and has been densified in 2008 by incorporating 45 sites for relative gravity measurements with CG5 gravimeters. At the end of 2009, the relative gravity network will be densified again in its eastern part, i.e. in the Longitudinal Valley and the Central Range. A fourth set of absolute gravity measurements will also be performed at the same period. Most of the absolute sites have been measured with a good accuracy, about 1 or 2 μGal. Only the site located in Tainan University has higher standard deviation, due to the city noise. The stronger change in gravity reaches -7 μGal a -1 west of the Longitudinal Valley and might be explained by tectonic movement along a fault. A large decrease of -5 μGal a-1 is also measured in Tainan city and could be correlated with uplift of this region, also denoted by InSAR, leveling and GPS. Changes occurring in the Central Range are more difficult to interpret due to the small

  15. Universal Cosmic Absolute and Modern Science

    NASA Astrophysics Data System (ADS)

    Kostro, Ludwik

    The official Sciences, especially all natural sciences, respect in their researches the principle of methodic naturalism i.e. they consider all phenomena as entirely natural and therefore in their scientific explanations they do never adduce or cite supernatural entities and forces. The purpose of this paper is to show that Modern Science has its own self-existent, self-acting, and self-sufficient Natural All-in Being or Omni-Being i.e. the entire Nature as a Whole that justifies the scientific methodic naturalism. Since this Natural All-in Being is one and only It should be considered as the own scientifically justified Natural Absolute of Science and should be called, in my opinion, the Universal Cosmic Absolute of Modern Science. It will be also shown that the Universal Cosmic Absolute is ontologically enormously stratified and is in its ultimate i.e. in its most fundamental stratum trans-reistic and trans-personal. It means that in its basic stratum. It is neither a Thing or a Person although It contains in Itself all things and persons with all other sentient and conscious individuals as well, On the turn of the 20th century the Science has begun to look for a theory of everything, for a final theory, for a master theory. In my opinion the natural Universal Cosmic Absolute will constitute in such a theory the radical all penetrating Ultimate Basic Reality and will substitute step by step the traditional supernatural personal Absolute.

  16. Methods to calibrate the absolute receive sensitivity of single-element, focused transducers

    PubMed Central

    Rich, Kyle T.; Mast, T. Douglas

    2015-01-01

    Absolute pressure measurements of acoustic emissions by single-element, focused passive cavitation detectors would be facilitated by improved wideband receive calibration techniques. Here, calibration methods were developed to characterize the absolute, frequency-dependent receive sensitivity of a spherically focused, single-element transducer using pulse-echo and pitch-catch techniques. Validation of these calibration methods on a focused receiver were made by generating a pulse from a small diameter source at the focus of the transducer and comparing the absolute pressure measured by a calibrated hydrophone to that of the focused transducer using the receive sensitivities determined here. PMID:26428812

  17. Methods to calibrate the absolute receive sensitivity of single-element, focused transducers.

    PubMed

    Rich, Kyle T; Mast, T Douglas

    2015-09-01

    Absolute pressure measurements of acoustic emissions by single-element, focused passive cavitation detectors would be facilitated by improved wideband receive calibration techniques. Here, calibration methods were developed to characterize the absolute, frequency-dependent receive sensitivity of a spherically focused, single-element transducer using pulse-echo and pitch-catch techniques. Validation of these calibration methods on a focused receiver were made by generating a pulse from a small diameter source at the focus of the transducer and comparing the absolute pressure measured by a calibrated hydrophone to that of the focused transducer using the receive sensitivities determined here. PMID:26428812

  18. Shear bond strength to enamel after power bleaching activated by different sources.

    PubMed

    Can-Karabulut, Deniz C; Karabulut, Baris

    2010-01-01

    The purpose of the present study was to evaluate enamel bond strength of a composite resin material after hydrogen peroxide bleaching, activated by a diode laser (LaserSmile), an ozone device (HealOzone), a light-emitting diode (BT Cool whitening system), and a quartz-Plus. Fifty extracted caries-free permanent incisors were used in this study. Thirty-eight percent hydrogen peroxidegel was applied to sound, flattened labial enamel surfaces and activated by different sources. Enamel surfaces that had received no treatment were used as control samples. Bonding agent was applied according to the manufacturer's instructions and the adhesion test was performed according to ISO/TS 11405. Statistical analysis showed significant influence of the different activation technique of hydrogen peroxide on shear bond strength to enamel (ANOVA, LSD, P < 0.05). The data in this vitro explorative study suggest the activation of hydrogen peroxide by different sources may further affect the shear bond strength of subsequent composite resin restoration to enamel. Within the limitations of this in vitro study, further studies examining the structural changes of activated hydrogen peroxide-treated enamel are needed. Due to the different activation methods; duration of light irradiation effects, longer time periods may be needed before application of adhesive restorations to enamel, compared with non-activated bleaching. PMID:21069109

  19. Measurement of Absolute Carbon Isotope Ratios: Mechanisms and Implications

    NASA Astrophysics Data System (ADS)

    Vogel, J. S.; Giacomo, J. A.; Dueker, S. R.

    2012-12-01

    An accelerator mass spectrometer (AMS) produced absolute isotope ratio measurements for 14C/13C as tested against >500 samples of NIST SRM-4990-C (OxII 14C standard) to an accuracy of 2.2±0.6‰ over a period of one year with measurements made to 1% counting statistics. The spectrometer is not maximized for 13C/12C, but measured ∂13C to 0.4±0.1‰ accuracy, with known methods for improvement. An AMS produces elemental anions from a sputter ion source and includes a charge-changing collision in a gas cell to isolate the rare 14C from the common isotopes and molecular isobars. Both these physical processes have been modeled to determine the parameters providing such absolute measures. Neutral resonant ionization in a cesium plasma produces mass-independent ionization, while velocity dependent charge-state distributions in gas collisions produce relative ion beam intensities that are linear in mass at specific collision energies. The mechanisms are not specific to carbon isotopes, but stand alone absolute IRMS (AIR-MS) instruments have not yet been made. Aside from the obvious applications in metrology, AIR-MS is particularly valuable in coupled separatory MS because no internal or external standards are required. Sample definition processes can be compared, even if no exact standard reference sample exists. Isotope dilution measurements do not require standards matching the dilution end-points and can be made over an extended, even extrapolated, range.

  20. Absolute Timing Calibration of the USA Experiment Using Pulsar Observations

    NASA Astrophysics Data System (ADS)

    Ray, P. S.; Wood, K. S.; Wolff, M. T.; Lovellette, M. N.; Sheikh, S.; Moon, D.-S.; Eikenberry, S. S.; Roberts, M.; Lyne, A.; Jordon, C.; Bloom, E. D.; Tournear, D.; Saz Parkinson, P.; Reilly, K.

    2003-03-01

    We update the status of the absolute time calibration of the USA Experiment as determined by observations of X-ray emitting rotation-powered pulsars. The brightest such source is the Crab Pulsar and we have obtained observations of the Crab at radio, IR, optical, and X-ray wavelengths. We directly compare arrival time determinations for 2--10 keV X-ray observations made contemporaneously with the PCA on the Rossi X-ray Timing Explorer and the USA Experiment on ARGOS. These two X-ray measurements employ very different means of measuring time and satellite position and thus have different systematic error budgets. The comparison with other wavelengths requires additional steps such as dispersion measure corrections and a precise definition of the ``peak'' of the light curve since the light curve shape varies with observing wavelength. We will describe each of these effects and quantify the magnitude of the systematic error that each may contribute. We will also include time comparison results for other pulsars, such as PSR B1509-58 and PSR B1821-24. Once the absolute time calibrations are well understood, comparing absolute arrival times at multiple energies can provide clues to the magnetospheric structure and emission region geometry. Basic research on X-ray Astronomy at NRL is funded by NRL/ONR.

  1. Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.

    PubMed

    Stracka, Daniele; Jozefczuk, Szymon; Rudroff, Florian; Sauer, Uwe; Hall, Michael N

    2014-09-01

    The evolutionary conserved TOR complex 1 (TORC1) activates cell growth in response to nutrients. In yeast, TORC1 responds to the nitrogen source via a poorly understood mechanism. Leucine, and perhaps other amino acids, activates TORC1 via the small GTPases Gtr1 and Gtr2, orthologs of the mammalian Rag GTPases. Here we investigate the activation of TORC1 by the nitrogen source and how this might be related to TORC1 activation by Gtr/Rag. The quality of the nitrogen source, as defined by its ability to promote growth and glutamine accumulation, directly correlates with its ability to activate TORC1 as measured by Sch9 phosphorylation. Preferred nitrogen sources stimulate rapid, sustained Sch9 phosphorylation and glutamine accumulation. Inhibition of glutamine synthesis reduces TORC1 activity and growth. Poor nitrogen sources stimulate rapid but transient Sch9 phosphorylation. A Gtr1 deficiency prevents the transient stimulation of TORC1 but does not affect the sustained TORC1 activity in response to good nitrogen sources. These findings suggest that the nitrogen source must be converted to glutamine, the preferred nitrogen source in yeast, to sustain TORC1 activity. Furthermore, sustained TORC1 activity is independent of Gtr/Rag. Thus, the nitrogen source and Gtr/Rag activate TORC1 via different mechanisms. PMID:25063813

  2. A novel method for active fissile mass estimation with a pulsed neutron source

    NASA Astrophysics Data System (ADS)

    Dubi, C.; Ridnik, T.; Israelashvili, I.; Pedersen, B.

    2013-07-01

    Neutron interrogation facilities for mass evaluation of Special Nuclear Materials (SNM) samples are divided into two main categories: passive interrogation, where all neutron detections are due to spontaneous events, and active interrogation, where fissions are induced on the tested material by an external neutron source. While active methods are, in general, faster and more effective, their analysis is much harder to carry out. In the paper, we will introduce a new formalism for analyzing the detection signal generated by a pulsed source active interrogation facility. The analysis is aimed to distinct between fission neutrons from the main neutron source in the system, and the surrounding "neutron noise". In particular, we derive analytic expressions for the first three central moments of the number of detections in a given time interval, in terms of the different neutron sources. While the method depends on exactly the same physical assumptions as known models, the simplicity of the suggested formalism allows us to take into account the variance of the external neutron source—an effect that was so far neglected.

  3. Optical and Radio Properties of QSOS as a Function of Absolute Luminosity.

    NASA Astrophysics Data System (ADS)

    Pica, Andrew Joseph

    1982-03-01

    Photometric data for nearly 250 quasars, BL Lacertids, and active galaxies have been obtained at the Rosemary Hill Observatory during a continuous 13-year monitoring program. Long-term optical records for 130 of these sources are employed in an effort to assess the physical and cosmological properties of quasi-stellar objects. Photographic P and B magnitudes were obtained with the 76- and 46-cm telescopes at Rosemary Hill. Corrections for galactic absorption, emission lines, and the K-term are applied to the raw data yielding monochromatic flux densities at a standard emitted wavelength of 2500 (ANGSTROM). Long -term light curves are compiled for all objects and 3 levels of activity are determined for each individual source. The MEAN, BASE, and MAX brightness levels are then used to study QSOs in their average, quiescent, and active phases, respectively. Absolute intrinsic luminosities of all sources in the sample are computed from the monochromatic flux densities based on relativistic cosmological models. Radio -emitting quasars, radio-quiet QSOs, and active galaxies fall into 3 distinct groups and are examined separately. The cosmological properties of QSOs are studied by plotting apparent magnitude vs. redshift, the so-called Hubble diagram. Scatter in the diagram due to variability is substantially reduced by plotting log z vs. the MEAN, BASE, and MAX flux densities. The brightest QSOs at each redshift are then chosen as "standard candles" in an effort to determine if quasars obey Hubble's law for expanding universe. It is found that they fit the Hubble relation quite well if certain selection effects are accounted for. Other evidence for the cosmological origin of QSOs is briefly discussed. Variability provides a test as to whether individual quasars are essentially multiple in nature (the "Christmas Tree" model), or are single coherent sources (such as a massive black hole). The amplitude of variability vs. absolute luminosity relation is used to discriminate

  4. Absolute isotopic abundances of TI in meteorites

    NASA Astrophysics Data System (ADS)

    Niederer, F. R.; Papanastassiou, D. A.; Wasserburg, G. J.

    1985-03-01

    The absolute isotope abundance of Ti has been determined in Ca-Al-rich inclusions from the Allende and Leoville meteorites and in samples of whole meteorites. The absolute Ti isotope abundances differ by a significant mass dependent isotope fractionation transformation from the previously reported abundances, which were normalized for fractionation using 46Ti/48Ti. Therefore, the absolute compositions define distinct nucleosynthetic components from those previously identified or reflect the existence of significant mass dependent isotope fractionation in nature. The authors provide a general formalism for determining the possible isotope compositions of the exotic Ti from the measured composition, for different values of isotope fractionation in nature and for different mixing ratios of the exotic and normal components.

  5. Absolute calibration in vivo measurement systems

    SciTech Connect

    Kruchten, D.A.; Hickman, D.P.

    1991-02-01

    Lawrence Livermore National Laboratory (LLNL) is currently investigating a new method for obtaining absolute calibration factors for radiation measurement systems used to measure internally deposited radionuclides in vivo. Absolute calibration of in vivo measurement systems will eliminate the need to generate a series of human surrogate structures (i.e., phantoms) for calibrating in vivo measurement systems. The absolute calibration of in vivo measurement systems utilizes magnetic resonance imaging (MRI) to define physiological structure, size, and composition. The MRI image provides a digitized representation of the physiological structure, which allows for any mathematical distribution of radionuclides within the body. Using Monte Carlo transport codes, the emission spectrum from the body is predicted. The in vivo measurement equipment is calibrated using the Monte Carlo code and adjusting for the intrinsic properties of the detection system. The calibration factors are verified using measurements of existing phantoms and previously obtained measurements of human volunteers. 8 refs.

  6. Stimulus probability effects in absolute identification.

    PubMed

    Kent, Christopher; Lamberts, Koen

    2016-05-01

    This study investigated the effect of stimulus presentation probability on accuracy and response times in an absolute identification task. Three schedules of presentation were used to investigate the interaction between presentation probability and stimulus position within the set. Data from individual participants indicated strong effects of presentation probability on both proportion correct and response times. The effects were moderated by the ubiquitous stimulus position effect. The accuracy and response time data were predicted by an exemplar-based model of perceptual cognition (Kent & Lamberts, 2005). The bow in discriminability was also attenuated when presentation probability for middle items was relatively high, an effect that will constrain future model development. The study provides evidence for item-specific learning in absolute identification. Implications for other theories of absolute identification are discussed. (PsycINFO Database Record PMID:26478959

  7. Molecular iodine absolute frequencies. Final report

    SciTech Connect

    Sansonetti, C.J.

    1990-06-25

    Fifty specified lines of {sup 127}I{sub 2} were studied by Doppler-free frequency modulation spectroscopy. For each line the classification of the molecular transition was determined, hyperfine components were identified, and one well-resolved component was selected for precise determination of its absolute frequency. In 3 cases, a nearby alternate line was selected for measurement because no well-resolved component was found for the specified line. Absolute frequency determinations were made with an estimated uncertainty of 1.1 MHz by locking a dye laser to the selected hyperfine component and measuring its wave number with a high-precision Fabry-Perot wavemeter. For each line results of the absolute measurement, the line classification, and a Doppler-free spectrum are given.

  8. Crosswell CASSM(Continuous Active-Source Seismic Monitoring): Recent Developments (Invited)

    NASA Astrophysics Data System (ADS)

    Daley, T. M.; Niu, F.; Ajo Franklin, J. B.; Solbau, R.; Silver, P. G.

    2009-12-01

    Continuous active-source monitoring using borehole sources and sensors in a crosswell configuration has proven to be a useful tool for monitoring subsurface processes (Silver, et al, 2007; Daley, et al, 2007; Niu, et al, 2008). This recent work has focused on two applications: monitoring stress changes related to seismicity and monitoring changes in fluid distribution related to geologic storage of CO2. Field tests have demonstrated precision in travel time measurement of up to 1.1 x 10-7 s, and in velocity perturbation measurement of up to 1.1 x 10-5 (Niu, et al 2008). In this talk I will summarize our preceding work and discuss current developments. Current efforts address both hardware and design challenges to improving the methodology. Hardware issues include deployment of multiple piezoelectric sources in shallow and deep boreholes, source and sensor deployment on tubing inside casing, and deployment with other monitoring instrumentation. Design issues are focused on use of multiple sources and/or sensors to obtain optimal spatial resolution for monitoring processes in the interwell region. This design issue can be investigated with optimal experiment design theory. New field experiments for monitoring seismicity (at SAFOD) and CO2 injection (at a US Dept of Energy pilot) are in the design/deployment stage. Current status of these projects will be discussed. References: Silver, P.G., Daley, T.M., Niu, F., Majer, E.L., 2007, Active source monitoring of crosswell seismic travel time for stress induced changes, Bulletin of Seismological Society of America, v97, n1B, p281-293. Daley, T.M., R.D. Solbau, J.B. Ajo-Franklin, S.M. Benson, 2007, Continuous active-source monitoring of CO2 injection in a brine aquifer, Geophysics, v72, n5, pA57-A61, DOI:10.1190/1.2754716. Niu, F., Silver, P.G., Daley, T.M., Cheng, X., Majer, E.L., 2008, Preseismic velocity changes observed from active source monitoring at the Parkfield SAFOD drill site, Nature, 454, 204-208, DOI:10

  9. fMRI activation patterns in an analytic reasoning task: consistency with EEG source localization

    NASA Astrophysics Data System (ADS)

    Li, Bian; Vasanta, Kalyana C.; O'Boyle, Michael; Baker, Mary C.; Nutter, Brian; Mitra, Sunanda

    2010-03-01

    Functional magnetic resonance imaging (fMRI) is used to model brain activation patterns associated with various perceptual and cognitive processes as reflected by the hemodynamic (BOLD) response. While many sensory and motor tasks are associated with relatively simple activation patterns in localized regions, higher-order cognitive tasks may produce activity in many different brain areas involving complex neural circuitry. We applied a recently proposed probabilistic independent component analysis technique (PICA) to determine the true dimensionality of the fMRI data and used EEG localization to identify the common activated patterns (mapped as Brodmann areas) associated with a complex cognitive task like analytic reasoning. Our preliminary study suggests that a hybrid GLM/PICA analysis may reveal additional regions of activation (beyond simple GLM) that are consistent with electroencephalography (EEG) source localization patterns.

  10. Constructing probabilistic models for realistic velocity distributions based on forward modeling and tomographic inversion: applications for active and passive source observation schemes

    NASA Astrophysics Data System (ADS)

    Koulakov, I. Yu.

    2009-04-01

    Seismic tomography is like a photography taken by a camera with deformed and blurred lenses. In the resulting tomograms, colors (amplitudes of anomalies) and shapes of objects are often strongly biased and are usually not representing the reality. We propose an approach which allows investigating properties of the "camera" and retrieving most probable shapes and amplitudes of anomalies in the real Earth. The main idea of this approach is to construct a synthetic model which, after performing forward modeling and tomographic inversion, reproduces the same amplitudes and shapes of patterns as after inversion of observed data. In this modeling, the conditions of the tomographic inversion (damping, grid spacing, source location parameters etc) should be absolutely identical to the case of the observed data processing. The a priori information, if available any, should be taken into account in this modeling to decrease the uncertainty related to fundamental non-uniqueness of the inversion problem. In the talk, several examples of applying this approach at various scales for different data schemes are presented: (1) regional scheme which uses the global data of the ISC catalogue (with examples of regional upper mantle models in Europe and central Asia); (2) local earthquake tomography scheme (illustrated with models in Toba caldera area and in Central Java); (3) seismic profiling which is based on active source refraction travel time data (with examples of several deep seismic sounding profiles in Central Pacific and subduction zones in Chile).