We have studied the effect of varying concentrations of benzene in the inhaled air of mice being exposed 6 hrs/day, 5 days/wk., for from two weeks through 16 weeks and observed blood counts, absolute cellularity of bone marrow, levels of pluripotent stem cells, fraction of the stem cells in DNA synthesis, and/or the incidence of leukemia, and the ...
Energy Citations Database
... TITLE: Nutritional Status, DNA Damage, and Tumor Pathology ... 15. SUBJECT TERMS Nutrition, DNA damage and repair, Breast tumor pathology ...
DTIC Science & Technology
Gene silencing by aberrant epigenetic chromatin alteration is a well-recognized event contributing to tumorigenesis. While genetically engineered tumor-prone mouse models have proven a powerful tool in understanding many aspects of carcinogenesis, to date few studies have focused on epigenetic alterations in mouse tumors. To uncover epigenetically silenced ...
PubMed Central
Devleopment of tumors is associated with the appearance ... non-tumor-bearing tissue from diseased fish. Copy numbers of DVLA DNA in tumors ...
NASA Website
Partial contents: Mapping, sequencing, and related studies of polyoma and SV40 nucleic acids; Mapping and other studies of DNA of adenoviruses, herpesviruses, and EBV; Studies of DNA tumor virus proteins; Studies of integrated tumor virus DNA and mechanis...
National Technical Information Service (NTIS)
BackgroundSensitivity of breast tumors to anticancer drugs depends upon dynamic interactions between epithelial tumor cells and their microenvironment including stromal cells and extracellular matrix. To study drug-sensitivity within different compartments of an individual tumor ex vivo, culture models directly established from fresh ...
Mutations of mitochondrial (mt) DNA, particularly the 4977 bp long common deletion, are increased in aging tissues and preferentially found in chronologically and photoaged skin. Mutations of human mitochondrial DNA (mtDNA) have also been identified in malignant tumors of the skin and of other organs. However, ...
PubMed
The authors examined the methylation status of CCGG sites in hepatitis B virus (HBV) DNA to determine whether methylation could be responsible for the selective expression of the HBV surface gene in chronic hepatitis B infection and hepatocellular carcinoma. Infected liver tissue from patients with low levels of viral replication was analyzed for HBV DNA ...
... Microsatellite instability (MI) in plasma DNA was infrequent, non-concordant with paired tumor, and inconsistent in serial samples. ...
Growth of L1210 leukemia cells which had been previously incubated with thymus DNA was inhibited. Leukemia-cell DNA did not affect tumor growth under similar conditions. Pretreatment of the thymus DNA with deoxyribonuclease suppressed the DNA-induced inhibition. Both ribonuclease-treated ...
NASA Astrophysics Data System (ADS)
Because activation of p53 can trigger cell cycle arrest and apoptosis, it is necessary for a cell to suppress this activation until it is absolutely required for survival. The mechanisms underlying this important regulatory event are poorly understood. Here we show that nucleophosmin (NPM) acts as a natural repressor of p53 by setting a threshold for p53 activation in response ...
AD_____ Award Number: W81XWH-05-1-0494 TITLE: Tumor Suppression by BRCA-1: A Critical Role at DNA Replication Forks ...
... Accession Number : ADA463242. Title : Tumor Suppression by BRCA-1: A Critical Role at DNA Replication Forks. Descriptive Note : Final rept. ...
... Accession Number : ADA471508. Title : Nutritional Status, DNA Damage, and Tumor Pathology. Descriptive Note : Final addendum rept. ...
... Accession Number : ADA447516. Title : Nutritional Status DNA Damage and Tumor Pathology. Descriptive Note : Final rept. ...
... Title : Genetic Analysis of DNA Repair Deficiency in Novel Non-Tumor Adjacent and Tumor Cell Lines Suggests a New Paradigm of Breast Cancer ...
Tumor induction in athymic nude mice can be used to detect dominant transforming genes in cellular DNA. Mouse NIH 3T3 cells freshly transfected with either cloned Moloney sarcoma proviral DNA or cellular DNA's derived from virally transformed cells induced tumors when injected into athymic ...
In real-time quantitative PCR studies using absolute plasmid DNA standards, a calibration curve is developed to estimate an unknown DNA concentration. However, potential differences in the amplification performance of plasmid DNA compared to genomic DNA standards are often ignore...
EPA Science Inventory
Autologous hematopoietic stem cell transplantation (HSCT) has resulted in improved event-free survival for patients with advanced neuroblastoma, but the majority of these patients still relapse. We have shown that transient transfection of mouse neuroblastoma cells with plasmid DNA vectors encoding immune co-stimulatory molecules generates cell-based vaccines capable of ...
