... The plasma Cmax values for males ... extensive, with drug derived radioactivity ... RADIOACTIVITY, ABSORPTION, DRUGS, INGESTION(PHYSIOLOGY ...
DTIC Science & Technology
A comprehensive knowledge of the absorption, distribution, metabolism and elimination of a compound is important for the interpretation of pharmacology and toxicology studies. Tissue distribution studies are essential in providing information on distribut...
National Technical Information Service (NTIS)
1,2,3,4 and 1,2,4,5-tetrachlorobenzene are intermediates in the synthesis of various chlorinated compounds. Since personnel are being exposed to tetrachlorobenzene in the plant, studies on absorption, distribution and metabolism need to be conducted. Samp...
A multi-sector international group of government, academic, and industry scientists has developed a proposal for an improved testing scheme for assessing the safety of crop protection chemicals. Incorporation of pharmacokinetic studies describing the absorption, distribution, me...
EPA Science Inventory
... safety of quercetin including absorption, distribution, metabolism, and ... the term color additive means a material ... For example, beta-carotene is both approved ...
Center for Food Safety and Applied Nutrition (CFSAN)
... not more than 2 percent of the beta-carotene color preparation. ... Mitsubishi describes published studies relating to the absorption, distribution, metabolism and ...
... Radiation Safety Officer: ... to maintain -10 to -30°C, protected from light (see protocol ... previous samples, data from the Method B analysis for Female ...
... orbital lachrymal gland Level C: Harderian gland/adrenal gland Level D: thyroid Level E: brain and spinal cord ... Pharmacokinetics and blood levels ...
... derived drug product made from pig tissue (porcine intestinal mucosa ... These factors can alter the absorption, distribution, metabolism, excretion, and ...
Center for Drug Evaluation (CDER)
... For subjects with extensive prior nucleoside use, double boosted PIs (eg ... that might interfere with drug absorption, distribution, metabolism or excretion -Any ...
The update brings the total coverage of the datafile to 4078 articles on the absorption, distribution, metabolism, and excretion of approximately 3000 chemicals for oral routes of administration in laboratory animals or in man. Both quantitative and quali...
The update for 1985-1987 covers 863 articles on the absorption, distribution, metabolism, and excretion of chemicals for oral routes of administration in laboratory animals or in humans. Quantitative and qualitative studies are included. Extracted data fi...
The datafile contains 3273 articles on the absorption, distribution, metabolism, and excretion of approximately 2600 chemicals for oral routes of administration in laboratory animals or in man. Both quantitative and qualitative studies were included. Extr...
Current concepts of Pu metabolism are reviewed. Metabolic models of the Pu intake by human populations of mixed age are based on certain over-simplified assumptions which are here considered and the factors that influence the absorption and distribution of Pu in animals and the long-term fate of Pu are ...
Energy Citations Database
... Title : Iron Metabolism: The Regulation of Intestinal Absorption of Iron and Metabolic Effects of Iron Deficiency. Descriptive Note : Final rept.,. ...
... Absorption, distribution, metabolism, and excretion In experimental animals, AA is rapidly and extensively absorbed from the gastrointestinal tract following ...
Current research in predictive toxicology has focused on describing the kinetics of absorption, distribution, metabolism, and elimination of xenobiotics administered to living systems. ata obtained form these toxicopharmacokinetic studies are critical for evaluating the efficacy,...
There are several factors which alter an individual's risk for an environmentally related illness. A major determinant is the age of the individual. The toxicodynamic processes which determine exposure, absorption, distribution, metabolism, injury repair ...
In order to obtain information on the potential transport of ingested Pu and to gain additional information on Pu deposition patterns in ruminants, a series of metabolism studies with dairy cows were conducted. Results are presented on tissue uptake following oral $sup 238$Pu administration. (CH)
...or serum anti-SRBC IgM levels, respectively. 1 If absorption/distribution/metabolism/excretion (ADME) data are...respond because the antigen was accidentally injected into the intestinal tract. (B) The activity of each new batch of...
Code of Federal Regulations, 2010
The tissue distribution. elimination, and metabolism of radioactivity were examined following a single oral administration of 14C-RDX, at a target dose of 45 mg/kg, to male and female Yucatan minipigs. Blood, urine, and feces were collected through 24 hou...
Absorption, metabolism, and tissue distribution studies were conducted in the rat with 14C-biphenyl ring-labeled Direct Blue 15, a 3,3'-dimethoxybenzidine (DiMxBzd) based azo dye; Direct Red 2, based on 3,3'-dimethylbenzidine (DiMeBzd) and the correspondi...
The absorption of palmitic acid-1-C/sup 14/ by ascites tumor cells was studied in vitro. Palmitate was metabolized more rapidly from its albumin complex than from buffer alone, but the albumin carrier was not absorbed or metabolized. Cyanide-inhibited cells absorbed palmitate from ihe medium but did noi ...
... Four patients with adult coeliac disease and 4 ... Descriptors : *METABOLIC DISEASES, *BIOLOGICAL ABSORPTION, *PROTEINS, BIOLOGICAL ...
... The absorption of dextrose decreased markedly with age, but age only slightly influenced the absorption of fructose. The ...
... Descriptors : *YEASTS, RADIATION EFFECTS, CELL DIVISION, METABOLISM, BIOLOGICAL ABSORPTION, PHOSPHORUS, PHOSPHATES ...
... THYROID GLAND, METABOLISM, ABSORPTION, TOXIC TOLERANCES, EXCRETION, MICE, PERITONEUM, RESPIRATION, FLUORIDES ...
The absorption, distribution, metabolism and excretion of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) was studied in male F344 rats. ral absorption was dose-dependent. bsorption of 1 nmol/kg by both the oral and intratracheal (itr) routes was -80%, whereas only -12% was absorbed th...
Dermal absorption, distribution, and metabolism of 1,3-diphenylguanidine (DPG), widely used as an accelerator in processing rubbers and in food packaging, was studied in adult female Sprague-Dawley rats. DPG shows 10% penetration through clipped back skin of the rats in 5 days. T...
Drug-metabolizing enzymes and membrane transporters work in concert to play crucial roles in drug absorption, distribution, and elimination. It is well recognized that genetic variation in drug-metabolizing enzymes contributes substantially to interindividual differences in drug response. With the notable ...
PubMed Central
The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene ...
The disposition and metabolism of a single oral 10 mg/kg (LD50) of uniformly phenyl-labeled (14C)EPN (O-ethyl O-4 nitrophenyl (14C) phenylphosphonothioate) were studied in adult hens. The birds were protected from acute toxicity with atropine sulfate. Three treated hens were kill...
Absorption, distribution, metabolism and excretion were studied in rats following a single oral administration of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) at a dose of 250 mg/kg. About 65% and 24% of the dose were excreted into urine and feces, respectively, for 3 days after administration of labeled CBS (cyclohexyl-14C). Biliary ...
PubMed
Contents: Food composition and energy values; Animal nutrition; Plant nutrition; Digestion and absorption; Nutrient function, deficiency, and excess; Animal energy exchange; Metabolic pathways; Plant metabolism; Metabolic end products.
There are five possible processes of intestinal absorption of xenobiotics. These are active transport, passive diffusions, pinocytosis, filtration through �pores,� and lymphatic absorption. The passive diffusion is major process for transport of foreign chemicals across the intestine. Though the lymphatic absorption of drugs is not ...
... Abstract : Studies concerning the mechanisms of intestinal glucose absorption indicate that the monophosphoesterases are not distributed along ...
... LIVER DISEASES, BIOLOGICAL ABSORPTION, ALCOHOLISM, FATTY ACIDS, DIGESTIVE SYSTEM, PHENYLALANINE, OLEIC ACID, ASCITES ...
