A comprehensive knowledge of the absorption, distribution, metabolism and elimination of a compound is important for the interpretation of pharmacology and toxicology studies. Tissue distribution studies are essential in providing information on distribut...

...is handled in the body, and includes absorption, tissue distribution, biotransformation... � means the study of the rates of absorption, tissue distribution, biotransformation...be used to determine the kinetics of absorption of the test...

...handled in the body and includes absorption, tissue distribution, biotransformation...and excretion. (3) Percent absorption means 100 times the ratio...means the study of the rates of absorption, tissue distribution,...

... derived drug product made from pig tissue (porcine intestinal mucosa ... These factors can alter the absorption, distribution, metabolism, excretion, and ...

... 855. CrossRefFurr, H. C. and R. M. Clark. Intestinal absorption and tissue distribution of carotenoids. Nutritional Biochemistry 1997. ... ...

The photoacoustic technique can be used to quantify tissue absorption spectrum in a wide spectral range from visible to near infrared. As the photoacoustic signal intensity is proportional to tissue optical absorption coefficient and light fluence, it is important to know the local light fluence at the regional ...

Recently, terahertz wave imaging has been shown to have potential in medical and biological applications. However, absorption by liquid water in tissues hinders the measurement of thick samples. In this study, porcine tissue was frozen to temperatures below -33 �C to prevent this absorption. Consequently, the ...

Current concepts of Pu metabolism are reviewed. Metabolic models of the Pu intake by human populations of mixed age are based on certain over-simplified assumptions which are here considered and the factors that influence the absorption and distribution of Pu in animals and the long-term fate of Pu are discussed. The factors examined include; ...

The absorption, tissue deposition, retention, and excretion of ingested lead is in large part due to associated dietary factors. Young suckling calves are extremely susceptible to low doses of lead, especially when maintained totally on milk. Unfortunately, the complexity of milk makes it difficult to determine which constituent is actually responsible for ...

Synchrotron x-ray microscopy (SXRM) in both emission and absorption modes has been used to examine elemental distributions in specimens of rat tibia, human deciduous teeth, and an orthopedic implant phantom. The work was performed with a spatial resolution of 8 {mu}m for the emission work and 25 {mu}m for the absorption work. The ...

The present article provides a theoretical description of the changes of interstitial hydrostatic pressure, tissue hydration, and protein distribution in the tissue during a peritoneal dwell with isotonic fluid. The mathematical model is based on the concept of uniformly distributed capillary and lymphatic systems ...

Diffuse optical tomography (DOT) makes it possible to reconstruct, in two or three dimensions, the internal structure of the biological tissues based on the distribution of the absorption coefficient and the reduced scattering coefficient, using optical measurements at multiple source � detector positions on the ...

Radiation effects on silicone gel and dose distribution of radiation through mammary prostheses were studied. Silicone gel behaves like tissue. Half value thickness for silicone gel and water are almost the same. Linear absorption coefficient for silicone gel and water are comparable.

A review of the possible therapeutic advantages of negative pions is given and the more prolific of the dedicated facilities are described. The results are given of an examination of the microdosimetry of negative pion absorption in tissue through the mea...

... of iron absorption during digestion and alter the distribution of iron to other parts of the body. As a result, iron accumulates in tissues and organs, which can disrupt their normal functions. Each type of hemochromatosis is caused by mutations ...

In order to obtain information on the potential transport of ingested Pu and to gain additional information on Pu deposition patterns in ruminants, a series of metabolism studies with dairy cows were conducted. Results are presented on tissue uptake following oral $sup 238$Pu administration. (CH)

The report presents formulae derived for calculating the tolerable concentrations in water and in air that is ingested or inhaled by humans, an abstract of the data on absorption and tissue distribution of fission products, and the results obtained by combining the two. (ACR)

The mass of tissue irradiated by an internal emitter depends upon the distribution of the radionuclide within the organism and the type of radiation emitted. The range (95% absorption) of low-energy electron effectively defines the sensitive volume in whi...

The absorption, distribution and retention of the heavy metals lead and cadmium as well as their mutual influence and their effects on the iron, copper, zinc and calcium contents in the tissues of fat calves were investigated under food-hygienic and clini...

We have demonstrated a new method for imaging melanin with two-color excited state absorption microscopy. If one of two synchronized mode-locked pulse trains at different colors is intensity modulated, the modulation transfers to the other pulse train when nonlinear absorption takes place in the medium. We can easily measure 10-6 ...

Objective: To review data on pharmacokinetic factors that influence the absorption and tissue distribution for individual antibiotic agents to better inform clinicians on rational dosing considerations of oral antibiotics for the treatment of acne vulgaris. The focus is placed on the most commonly prescribed oral antibiotics for acne ...

Objective: To review data on pharmacokinetic factors that influence the absorption and tissue distribution for individual antibiotic agents to better inform clinicians on rational dosing considerations of oral antibiotics for the treatment of acne vulgaris. The focus is placed on the most commonly prescribed oral antibiotics for acne ...

... Title : THE MECHANISM OF ABSORPTION OF ULTRAHIGH FREQUENCY ... TISSUES, AS RELATED TO THE PROBLEM OF TOLERANCE DOSAGE. ...

In this paper, spatial distributions of light emitting from slice chicken muscle tissue and sub-skin fatty tissue are measured on experiment. Experimental results indicate that muscle tissue have better diffraction ability, therefore, muscle tissue can't be treated as a kind of highly ...

Hyperspectral imaging (HSI) is a chemical imaging modality with spectroscopic information. This technique was often used in agricultural or pharmaceutical industries. But there have been a few reports for clinical medical applications. In near-infrared (NIR) wavelength region, the significant absorption peaks are often observed by the overtone of midinfrared molecular ...

This report presents results from a study conducted to determine the toxicity of Mercury in soils sediments samples. Mice were fed via diet, soils and sediment, from various locations along the East Fork Poplar creek. Tissue distribution of pollutants was determined at various intervals. The tissue level relative to toxicity was used ...

Mice were fed 20 ..mu..g cadmium chloride (CdCl/sub 2/) and cadmium-methallothionein (CdMt) once a week for 5 weeks using Cd-109 as a tracer. Body burden measurements suggest that the levels in tissues drop after the third week when CdMt is the source, but continue to increase with CdCl/sub 2/. Tissue distribution is tabulated as % ...

The retention of and tissue distribution of Cd administered as CdCl/sub 2/ or Cd-thionein (Cd-TH) was determined. The tissue distribution of Cd was determined 7 days after oral administration of various dosages of CdCl/sub 2/ (1-10,000 ..mu..g Cd/kg) to rats. The results indicated that the concentration of Cd in ...