A 59-year-old Japanese man presented with depressed mood, insomnia, abnormal behavior and dementia. Visual and gait disturbance with ataxia also developed. Diffusion-weighted MRI showed widespread regions of hyperintensity in the bilateral cerebral cortex. The patient died at 62 after a progressive clinical course of 32 months. Myoclonus, periodic sharp-wave complexes on EEG, and akinetic mutism ...
PubMed
A 73-year-old Japanese woman showed slowly progressive aphasia, apraxia and dementia. She had no family history of prion disease or dementia. One year later she showed parkinsonism and corticobasal degeneration was initially suspected. On MRI, the left temporal neocortex seemed swollen on T2-weighted images in the initial stage, and a later high-signal intensity region was observed in the cerebral ...
Prp19 is the founding member of the NineTeen Complex, or NTC, which is a spliceosomal subcomplex essential for spliceosome activation. To define Prp19 connectivity and dynamic protein interactions within the spliceosome, we systematically queried the Saccharomyces cerevisiae proteome for Prp19 WD40 domain interaction partners by ...
PubMed Central
Scrapie-associated fibrils (SAF) are disease-specific structures found in extracts of the brains of animals affected with scrapie. These structures are pathological aggregates of a normal host protein called PrP. In collaboration with Konrad Beyreuther (Heidelberg), we have characterized the multiple forms of PrP found in SAF fractions from mouse brain ...
Proline-rich protein (PRP), a cell wall protein of plant, has been studied in many plant species. Yet, none of the PRPs has been functionally elucidated. Here we report a novel flower-specific PRP designated OsPRP3 from rice. Expression analysis showed that the OsPRP3 transcript was mainly present in rice flower ...
We report the case of a 67-year-old man with MM2-cortical-type sporadic Creutzfeldt-Jakob disease (sCJD) with a rapidly progressive clinical course of 5 months. Initial symptoms were progressive memory disturbance and dementia. MRI revealed high signal-intensity lesions on diffusion-weighted images in the bilateral frontal and occipital cortices. Myoclonus and periodic sharp-wave complexes on the ...
Host prion protein (PrP) is most abundant in neurons where its functions are unclear. PrP mRNA transcripts accumulate at key developmental times linked to cell division arrest and terminal differentiation. We sought to find if proliferative arrest was sufficient to cause an increase in PrP in developing neurons. ...
The repair process of tendon injuries, which are common in both human and equine athletes, is slow and the quality of the repair tissue is often inferior to the original tendon tissue, which frequently leads to re-injury. The relatively poor vascularization of tendons is considered to be one of the reasons for their limited healing potential. Recently, platelet-rich plasma ...
Protein misfolding cyclic amplification (PMCA) recapitulates the prion protein (PrP) conversion process under cell-free conditions. PMCA was initially established with brain material and then with further simplified constituents such as partially purified and recombinant PrP. However, availability of brain material from some species or brain material from ...
Transmissible spongiform encephalopathies (TSE) are neurodegenerative diseases caused by an infectious agent with viral properties. Host prion protein (PrP), a marker of late stage TSE pathology, is linked to a similar protein called Shadoo (Sho). Sho is reduced in mice infected with the RML scrapie agent, but has not been investigated in other TSEs. Although ...
Prion protein (PrP) is abundant in the nervous system, but its role remains uncertain. Prion diseases depend on an aggregation of the protein that is likely to interfere with its normal function. Loss of function does not in itself cause neurodegeneration, but whether it contributes to the clinical features of the disease remains an open question. Patients ...
Human proteins 15.5K and hPrp31 are components of the major spliceosomal U4 snRNP and of the minor spliceosomal U4atac snRNP. The two proteins bind to related 5'-stem loops (5'SLs) of the U4 and U4atac snRNAs in a strictly sequential fashion. The primary binding 15.5K protein binds at K-turns that exhibit identical sequences in the two snRNAs. However, RNA sequences contacted ...
After infection with RML murine scrapie agent, transgenic (tg) mice expressing prion protein (PrP) without its glycophosphatidylinositol (GPI) membrane anchor (GPI?/? PrP tg mice) continue to make abundant amounts of the abnormally folded disease-associated PrPres but have a normal life span. In contrast, all ...
Although the wild-type prion protein (PrP) is abundant and widely expressed in various types of tissues and cells, its physiological function(s) remain unknown, and PrP knockout mice do not exhibit overt and undisputed phenotypes. Here we showed that PrP is expressed on the surface of several bone marrow cell ...
Plaque-like congenital osteoma cutis was treated with disodium etidronate. We could not prove, however, any definitely positive effect. PMID:3092485
The Fact Sheet summarizes the steps involved in a thorough PRP Search, including determination of liability, PRP Search Planning, the PRP Search Process and compiling PRP Search Reports.
Energy Citations Database
Polysaccharides and glycosaminoglycans (GAGs), particularly heparin, have been shown to directly affect fibrillation phenomena and the biological activities of amyloid proteins. We present a systematic analysis of the impact of heparin upon fibrillation of the amyloidogenic determinant of the prion protein PrP(106-126). Experimental data, including thioflavin T fluorescence, ...
We have studied developmental and light regulation of mRNAs encoding a putative cell wall proline-rich protein (PvPRP1), cell wall glycine-rich proteins (GRPs), and cell wall hydroxyproline-rich glycoproteins (HRGPs) in bean (Phaseolus vulgaris). Light increases the levels of these mRNAs 2- to 150-fold in highly spatially regulated patterns during seedling development. These ...
Figure 3 which depicts a condition from a typical psychological refractory period ( PRP) experiment. In the PRP paradigm, two tasks are presented in close ...
NASA Website
... Harvest PRP Separation System. Applicant: Harvest Technologies Norwell, MA. 510(k) number: BK000037. Product: Harvest PRP Separation System. Date: 2/5/2001. -. ...
Center for Biologics Evaluation and Research (CBER)
... CEQer PRP Assay. Applicant: Biometric Imaging, Inc. Mountain View, CA. 510(k) number: BK970016. Product: CEQer PRP Assay. Date: 9/18/98. -. ...
Trials of Haemophilus influenzae bype b capsular polysaccharide (PRP), aggregated PRP (PRP-A) and purified capsular polysaccharide of Escherichia coli K100 (KC) as potential vaccines in humans are reported. PRP-A and KC appear not to induce significant ad...
National Technical Information Service (NTIS)
The purpose of the document is to provide guidance on potentially responsible parties (PRP) search planning and management and on the content of PRP search reports. The guidance applies to sites in the remedial program and it supplements the August, 1987 PRP Search Manual.
In specific, this PRP will help ensure contractor coordination and cooperation to ... The PRP will be available for initial disbursement on the yearly ...
... Accession Number : ADA271698. Title : Nuclear Weapon Personnel Reliability Program (PRP). Corporate Author : ASSISTANT ...
DTIC Science & Technology
Comparison Feedback Calculations: PRP vs. Kernel Method. Feedback calculations agree to within ~10% of conventional PRP. ...
Chronic wasting disease (CWD) is a fatal prion disease in deer and elk. Unique among the prion diseases, it is transmitted among captive and free-ranging animals. To facilitate studies of the biology of CWD prions, we generated five lines of transgenic (Tg) mice expressing prion protein (PrP) from Rocky Mountain elk (Cervus elaphus nelsoni), denoted Tg(ElkPrP), and two lines ...
Samples of tissue from the central nervous system (cns), the lymphoreticular system (lrs) and the rectal mucosa of a large number of scrapie-exposed sheep, with and without signs of clinical disease, were examined immunohistochemically for evidence of disease-associated prion protein (PrP(d)). The rectal mucosa has received almost no attention so far in scrapie diagnosis, despite its ...
The key pathogenic event in prion disease involves misfolding and aggregation of the cellular prion protein (PrP). Beyond this fundamental observation, the mechanism by which PrP misfolding in neurons leads to injury and death remains enigmatic. Prion toxicity may come about by perverting the normal function of PrP. If so, ...
The full length cDNA of a prion protein (PrP) encoding gene of guppy ( Poecilia reticulata) and the corresponding genomic DNA were cloned. The cDNA was 2245 bp in length and contained an open reading frame (ORF) of 1545 bp encoding a protein of 515 amino acids, which held all typical structural characteristics of the functional PrP. The cloned genomic DNA ...
NASA Astrophysics Data System (ADS)
Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained ...
Transactions on Systems, Man, Cybernetics, 27, 195-207 Liu, Y., Feyen, R., and Tsimhoni, O. (2004). QueuingModeling Psychological Refractory Period (PRP) and Practice Effect on PRP with Queuing Networks information processing in dual-task situations. This article describes a queuing network model of PRP
E-print Network
A previous report described the computer program PRP, which can be used to calculate the production cost (product price) of a product from a process plant when the investments, expenses, interest rates, rate of return on equity, and similar related data a...
Mar 15, 2011 ... The model approach and model parameters used generate the PRP are described ... The north polar PRP's were produced using the same datasets, ...
... factor controlling interspecies TSE susceptibility is prion protein (PrP) homology between the source and recipient species/genotypes. Furthermore, the efficiency with which the protease-resistant PrP (PrP...
NBII National Biological Information Infrastructure
...is not eligible for a TAG if your group is: (1) A �potentially responsible party� (PRP), receives money or services from a PRP, or represents a PRP; (2) Not incorporated as a nonprofit organization for the specific purpose of...
Code of Federal Regulations, 2010
...issue of liability of any participating PRP has been submitted for resolution, the...shall determine whether the participating PRP is liable pursuant to section 107(a...facility is divisible, any participating PRP whom the Arbitrator determines to be...
Code of Federal Regulations, 2011
We generated mice expressing cervid prion protein to produce a transgenic system simulating chronic wasting disease (CWD) in deer and elk. While normal mice were resistant to CWD, these transgenic mice uniformly developed signs of neurological dysfunction ?230 days following intracerebral inoculation with four CWD isolates. Inoculated transgenic mice homozygous for the transgene array developed ...
... D1LC1LL o:pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o0pRp D1LC1LL o:pRp D1LC1LL ...
Platelet-rich plasma stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. In addition, PRP functions as haemostatic by forming a fibrin clot. Also application of PRP enhances wound-healing in both soft and hard tissue. A survey of the literature to assess the current clinical experience and the possible effects of ...
Security Expand Personnel Security Personnel Security Appeals Board Personnel Reliability Program (PRP) Expand Personnel Reliability Program (PRP) Security Education Expand...
Science.gov Websites
Jul 7, 2010 ... PRP; Sensitivity kernel. Observing the feedbacks ... 1) Partial Radiative Perturbation (PRP) method [Wetherald and Manabe 1988] ...
... Accession Number : ADA290994. Title : Nuclear Weapon Personnel Reliability Program (PRP). Change 1. Corporate Author ...
Piston Core PRP 12 and Box Core PRB 12, taken at ... of Globigerinoides ruber ( white) in piston core PRP 12. The salinity is ...
Piston Core PRP 12 and Box Core PRB 12, taken at ... Caribbean obtained from piston core PRP 12. The SSTs are reconstructed ...
Page ARMD 9, paragraph 23 entitled "Performance Retainage Pool (PRP) - Master Contract. A.I.8". The percent amount for the PRP. ...
Aug 31, 2007 ... Can my Personal Reliability Program (PRP) be used instead of NACI ... The PRP may continue but a NACI must be initiated as the minimum ...
May 16, 2011 ... Task-switching interference and PRP interference: Similarities ... differences, PRP interference, similarities, task-switching interference ...
The high PRP used in the earler system resulted is an unknown eclipsing loss of ... required, all PRP's were sequenced. A 6 dB loss factor was provided to ...
ACARS (ACR) and PIREPS (PRP), c) KSC/CCAS towers (TWR) and 50 MHz and 915 ...... PRP. Mean number of Radar and GOES sounding observations ...
BackgroundThe prolactin-related proteins (PRPs) are non-classical placental-specific members of the prolactin/growth hormone family. Among ruminants, they are expressed in the cotyledonary villi of cattle and goat. We investigated placental PRP in sheep in order to gain a comprehensive understanding of the function and evolution of these molecules. We also examined the ...
Disease Chronic wasting disease (CWD, prion, transmissible spongiform encephalopathy, PrP CWD )
... a murine PrP knockout background. The absolute species barrier between the infectious agent of TME and mice ... ...
... benefit from a new procedure called platelet-rich plasma (PRP) therapy. Used in Pittsburgh Steelers wide receiver ...
MedlinePLUS
... systems were chosen for further study: The Personalized Route Planner (PRP) ... A copy of the code for the PRP was obtained from Mr. Robert ...
Prion protein (PrP) is considered to associate with microtubule and its major component, tubulin. In the present study, octarepeat region of PrP (PrP51-91) was expressed in prokaryotic-expressing system. Using GST pull-down assay and co-immunoprecipitation, the molecular interaction between PrP51-91 and tubulin was ...
Mutations within a host cellular protein, PrP, have been associated with disease in the transmissible spongiform encephalopathies. Murine neuroblastoma cells persistently infected with mouse scrapie accumulate protease-resistant PrP (PrP-res), the abnormal form of PrP associated with disease in the transmissible spongiform ...
Proline-rich proteins (PRPs) are the most complex family of salivary peptides with distinct isoforms and PTMs. Up to date, only the serine phosphorylation at positions 8, 17, and 22 have been experimentally observed on acidic PRP (aPRPs), and at position 8 on basic PRP1 and 2. The presence of a glucoronyl group at Ser17 was also noticed on ...
BACKGROUND: Few studies have examined the effects of platelet-rich plasma (PRP) on intestinal anastomotic healing. The applied preparation methods and PRP concentrations used in the few studies that have been carried out varied markedly. Therefore, the positive effects of PRP on the anastomotic healing process remain unclear. The aim ...
Osteoma cutis is a rare lesion that consists of the presence of bone tissue within the dermis and/or hypodermis. It may be classified as primary osteoma cutis, when bone tissue develops in the skin without any pre-existing lesion and secondary osteoma cutis, which is more frequent and occurs when osseous tissue develops on a pre-existing lesion. We present a case of primary ...
