... abuse-deterrent drug formulations and on post-market assessment of their performance. ( FDA ) 4 ? 4 ? II. Tracking ... abuse deterrent drug formulations and on post-market assessment of their performance within 24 months; � Have DOD, ...

Abuse-deterrent opioid analgesic formulations can help reduce the risk of opioid diversion and abuse. Not all opioid analgesics are available as both extended- and immediate-release dosage forms in abuse-deterrent formulations. Clinicians may have to balance the clinical benefit of a product ...

It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain. One way to decrease the abuse of prescription opioid medications is to develop abuse deterrent formulations (or ADFs) that in some way ...

It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain. One way to decrease the abuse of prescription opioid medications is to develop abuse deterrent formulations (or ADFs) that in some way ...

The continued need for opioids to treat pain and their unavoidable link to abuse and addiction create a need for risk mitigation approaches that optimize their risk-benefit ratio. Abuse-deterrent formulations (ADFs) have emerged as a means for supporting opioid access while limiting abuse and its consequences. ...

Prescription drug abuse is a significant and growing health and socio-economical problem in the US and the world. According to the 2008 UN World Drug Report, the number of people who have consumed an illicit drug at least once in 2006/2007 reached 240 million, roughly 6% of the world population aged 15 to 64. In the last few years, pharmaceutical manufacturers started ...

The number of opioid analgesic prescriptions has increased since 1990. Opioids are being prescribed for longer periods of time for both cancer- and noncancer-associated moderate to severe chronic pain. Concurrent with the increased prescribing of opioids has been an increase in their diversion from prescribed use and their abuse; frequently, this abuse ...

Opioids are widely used for the treatment of patients with chronic pain; yet, the increase in their abuse, misuse, and diversion is an ongoing focus of regulatory, governmental, and legal scrutiny. As a consequence, clinicians are faced with numerous challenges in an effort to use opioids in appropriate patients with pain while minimizing the potential for opioid ...

Substance abuse in the military has serious and costly consequences. The aim of this research is to measure quantitatively the deterrence effect of the military's drug testing and 'zero tolerance' policies. A second purpose is to statistically measure the...

... This document had the title �Substance Abuse Prevention ... To compare rates of alcohol, illicit drug ... Pap tests and substance use during pregnancy.) ...

Both chronic pain and prescription opioid abuse are prevalent and exact a high toll on patients, physicians, and society. Health care professionals must balance aggressive treatment of chronic pain with the need to minimize the risks of opioid abuse, misuse, and diversion. A thorough, ongoing assessment can help fashion a multimodal therapeutic plan, ...

... Abstract : Recently, catnip, Nepeta cataria L. (Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection ...

... ml each of methyl alcohol and surfactant (Silwet L-77, Helena Chemical Corporation, Memphis, TN). All of the ... ...

The purpose of this review is to illustrate the utility and value of employing human self-administration procedures in medication development, including abuse liability assessments of novel medications and evaluation of potential pharmacotherapies for substance use disorders. Traditionally, human abuse liability testing has relied primarily on subjective ...

... 7 7 Pivotal Study 105 � Design: Randomized, double-blind, placebo- ... 8 Study 105 Primary Efficacy Endpoint: SPID48 Secondary endpoints followed suit Page 74. ...

Chronic pain is pain that persists past the normal time of healing, and is seen as a common problem with a significant socioeconomic impact. Pharmacological management for chronic non-cancer pain also involves the prescription of opioids, with the aim of an improved quality of life for the patient. New guidelines have been published to aid prescribing clinicians improve opioid safety and patient ...

... Chemistry/Formulation �Third party abuse potential �Ease of Synthesis/Precursor availability �Pyrolysis Products �Assess likelihood of Product ...

The use of remotely sensed data for eliminating abuses and mismanagement of land and water resources

Research on the intergenerational transmission of abuse hypothesis often only examined the "existence" of abuse. The current study utilizes retrospective recalls of incarcerated male defendants (N = 414), using questions formulated from the modified Conflict Tactics Scales. Five logistic regression models are run, representing a ...

Substance abuse in the workplace is a problem of enormous proportions. Hospitals, like other organizations, must recognize the potential risks posed by substance abuse and effectively deal with the problem. A nationwide study was conducted of hospital personnel managers' attitudes toward drug abuse and mandatory drug testing. The study ...

In the eighties, elder abuse cases became of paramount concern to policy makers and those working in fields serving older adults. Very little research, however, has examined how the justice system handles cases of elder abuse. In this paper, the results of a study assessing how various professionals recommended punishing those who harm elderly persons are ...

The abuse of alcohol causes health and social problems, such as sickness, death, injury, pain, suffering and crime. These harms impose an economic burden on society. Resources are used or foregone as a consequence of alcohol abuse. This article provides an estimate of the economic cost of alcohol abuse in Ontario in 1992. It uses the ...

The Department of Defense has rules and procedures to minimize the opportunity for error and improper behavior among those with access to strategic weapons, but no psychiatric screening system can predict with assurance who will or will not behave rationally during a crisis. Personal problems and institutional decision-making pressures may destroy nuclear deterrence. Certain ...

Nuclear strategy and national security are discussed in 17 papers, 9 official documents and statements, and a Senate debate report on the neutron warhead. In the post-Vietnam debate over the future role of the United States in world affairs, new political and military strategies have been formulated to deal with new realities. That debate continues today, and its implications ...

Three commercial neem-based insecticides, Agroneem, Ecozin, and Neemix, and a neem seed extract formulation, bitters, containing 1,036, 16,506, 471, and 223 microg/ml azadirachtin, respectively, were assessed for feeding and oviposition deterrence against gravid female boll weevils, Anthonomus grandis grandis Boheman, in the laboratory. In choice assays, ...

Risk evaluation and mitigation strategies (REMS) formerly known as Risk Minimization Action Plans (RiskMAPs) are a regulatory technique for dealing with anticipated risks of new medications and are especially important for new drugs with abuse potential. This paper describes the origin and history of risk-management plans for drugs that might be abused, ...

School counselors have a duty to formulate strategies that aid in the detection and prevention of child sexual abuse (American School Counselor Association, 2003). School counselors are charged with helping sexually abused children by recognizing sexual abuse indicators based on a child's symptomatology and/or ...

Length of treatment stay is consistently associated with positive posttreatment outcomes in the rehabilitation of drug-abusing offenders. However, past retention research centered on the examination of individual-level determinants to the exclusion of environmental predictors. In this study, the authors propose a rational choice framework in which treatment retention is viewed ...

... Waging Deterrence in the Twenty-First Century ... Deterrence campaigns start in peacetime and are intended to preserve the peace, but our ...

... Title : Conventional Deterrence and the Falkland Islands Conflict. ... This is why conventional deterrence failed in the Falkland Islands conflict. ...

The authors conducted an exploratory study among a convenience sample of 260 Jordanian men and women, using self-administered open and closed questions to examine the participants' approach toward wife abuse. In general, there was high awareness of wife abuse and the different types of abuse (mainly physical and psychological), a ...

The authors conducted an exploratory study among a convenience sample of 260 Jordanian men and women, using self-administered open and closed questions to examine the participants' approach toward wife abuse. In general, there was high awareness of wife abuse and the different types of abuse (mainly physical and psychological), a ...