Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein of 38 kDa in size, p38SJ, from a callus culture of Hypericum perforatum, which belongs to an emerging DINGG ...
PubMed
PubMed Central
... Accession Number : ADA405517. Title : Toxic Neuronal Death by Glyceraldehyde-3-Phosphate Dehydrongenase and Mitochondria. ...
DTIC Science & Technology
... Title : Toxic Neuronal Death by Glyceraldehyde-3-Phosphate Dehydrogenase and Mitochondria. Descriptive Note : Annual rept. ...
Methamphetamine (METH) is an illicit psychostimulant that is widely abused in the world. Several lines of evidence suggest that chronic METH abuse leads to neurodegenerative changes in the human brain. These include damage to dopamine and serotonin axons, loss of gray matter accompanied by hypertrophy of the white matter and microgliosis in different brain ...
Experiments are proposed to examine the molecular mechanism by which mustard chemical warfare agents induce neuronal cell death. DNA damage is the proposed underlying mechanism of mustard-induced neuronal cell death. We propose a novel research strategy t...
National Technical Information Service (NTIS)
Although the incidence of HIV-associated dementia (HAD) has declined, HIV-associated neurocognitive disorders (HAND) remain a significant health problem despite use of highly active antiretroviral therapy. In addition, the incidence and/or severity of HAND/HAD are increased with concomitant use of drugs of abuse, such as cocaine, marijuana, and methamphetamine. Furthermore, ...
... mechanism. 2. Investigate whether chronic exposure of CNS neurons to soman, VX, and sarin results in neuronal death. a ...
... Abstract : We investigated the temporal progression of apoptotic cell death in the rat piriform cortex after soman intoxication. ...
... ANTITOXINS, *NEUROTOXINS, *DEATH, STRATEGY, PENETRATION, MOLECULAR PROPERTIES, CONCUSSION, CYTOLOGY, MORBIDITY ...
This report presents information on drug abuse deaths that occurred in 1999 and were reported to the Drug Abuse Warning Network by 139 medical examiner (ME) facilities in 40 metropolitan areas. The data are not representative of all such deaths that occur...
... The number of FJ-B stained neurons was ... FJ-B staining does not discriminate between apoptotic ... acid induced neuronal and myelin degeneration in ...
... mustard chemical warfare agents induce neuronal cell ... mustard-induced DNA damage and neuronal ... the cytotoxic and DNA damaging properties of ...
Learn about drugs of abuse and how they affect neural communication. Let's start by reviewing the neuron by playing this game. Mad Mad Neuron Explain how drugs of abuse affect neurons. Include details on at least 7 specific drugs. Type your answers in a Word document and print to turn in for ...
NSDL National Science Digital Library
Apoptosis and autophagy are the two major types of programmed cell death (PCD) in neurons. Homeostatic autophagy often precedes apoptosis, and when apoptosis is blocked, the failure to keep homeostasis will lead to necrosis instead. It has been reported that human immunodeficiency virus (HIV) infected methamphetamine (Meth) abusers ...
Methamphetamine is a CNS stimulant with limited therapeutic indications, but is widely abused. Short-term exposure to higher doses, or long-term exposure to lower doses, of methamphetamine induces lasting damage to nigrostriatal dopamine neurons in man and animals. Strong evidence indicates that the mechanism for this detrimental effect on dopamine ...
This report presents information on deaths related to drug abuse that were reported to the Drug Abuse Warning Network (DAWN) by 141 participating medical examiners (MEs) in 42 metropolitan areas in 1998. The Office of Applied Studies in the Substance Abus...
... Title : The Impact of Exercise on the Vulnerability of Dopamine Neurons to Cell Death in Animal Models of Parkinson's Disease. ...
... Descriptors : *NEUROPHYSIOLOGY, *PARKINSONS DISEASE, * NEUROTOXINS ... MOTOR NEURONS, MITOCHONDRIA, DEGENERATION ...
