Synchrotron radiation imaging technique was used to in situ observe the dendrite growth of a solidifying Sn-Bi binary alloy under a direct current (dc) electric field. By applying a dc (7-32A/cm2) , the dendrite branching was suppressed, the dendrite tip was modified to be round or flat, and no tertiary ...
NASA Astrophysics Data System (ADS)
Infection of a dendritic cell with a lentivirus impairs the dendritic cell's ability to act as an antigen presenting cell that polarizes a naive T cell to develop along the Th1 pathway. This impairment is restored by infecting dendritic cells with lentivi...
National Technical Information Service (NTIS)
... the dendritic structures in the copolyfluorene. Both the photoluminescence and electroluminescence efficiencies of the polymer nanocomposites ...
DTIC Science & Technology
... groups�eg, dendritic structures�to the main chain of the polymer; such Page 5. 3 ... For the second-generation dendritic polymer nanocomposite, ...
The growth velocity of silicon <110> faceted dendrites as a function of the twin spacing was investigated by in situ observation. As the twin spacing increases, <110> dendrite growth velocity nonlinearly decreases. The theoretical <110> and <112> dendrite growth velocities were calculated on the basis of the ...
During year two of the granting period, we continued to study the efficacy of raising cytotoxic human T cell responses against the auto- antigens PAP and PSA with genetically modified autologous dendritic cells, The ability of dendritic cells (DCs), genet...
The major objective of this project is to establish a new modality for the treatment of breast cancer that employs the combination of chemokine gene-modified fibroblasts with breast tumor-pulsed dendritic cells (DC) to both recruit and/or concentrate from...
The major objective of this project is to establish a new modality for the treatment of breast cancer that employs the combination of chemokine gene modified fibroblasts with breast tumor pulsed dendritic cells (DC) to both recruit and/or concentrate from...
... dendritic cells (DC), a C-type lectin, DC-SIGN ... sites may affect the biological activity of lymphoid ... It is known that antibacterial agents can modify acute ...
... the efficacy of raising cytotoxic human T cell responses against the auto- antigens PAP and PSA with genetically modified autologous dendritic cells ...
... Accession Number : ADA412918. Title : Breast Cancer Immunotherapy with Intra-Tumoral Injection of Genetically Modified Dendritic Cells. ...
The purpose of this paper is to develop a method for calculating organelle transport in dendrites with a non-uniform cross-sectional area that depends on the distance from the neuron soma. The model is based on modified Smith-Simmons equations governing molecular motor-assisted organelle transport. The developed method is then applied to simulating ...
PubMed
Chronic stress produces consistent and reversible changes within the dendritic arbors of CA3 hippocampal neurons, characterized by decreased dendritic length and reduced branch number. This chronic stress-induced dendritic retraction has traditionally corresponded to hippocampus-dependent spatial memory deficits. However, anomalous ...
PubMed Central
Purpose. To investigate dendritic changes of retinal ganglion cells (RGCs) and the rate of dendritic shrinkage after retinal ischemia induced by acute elevation of intraocular pressure (IOP). Methods. After elevating the IOP to 110 mm Hg for 30, 60, 90, and 120 minutes, a confocal scanning laser ophthalmoscope (CSLO) was used to serially image the retinas ...
Neurons display a wide range of intrinsic firing patterns. A particularly relevant pattern for neuronal signaling and synaptic plasticity is burst firing, the generation of clusters of action potentials with short interspike intervals. Besides ion-channel composition, dendritic morphology appears to be an important factor modulating firing pattern. However, the underlying ...
Herein we developed a rapid and simple method which used surface-enhanced Raman spectroscopy (SERS) coupled with antibody-modified silver dendrites to detect ovalbumin (OVA), the egg white protein, introduced into whole milk. OVA was first captured out of milk by use of antibody-modified silver dendrites and then ...
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of nai?ve T cells in vitro with SWCNT-treated ...
A modified cellular automaton (MCA) coupled with a momentum and species transport model has been developed in order to predict the evolution of dendritic morphology during solidification of alloys in the presence of melt convection. In the present model, the cellular automaton algorithm for dendritic growth is incorporated with the ...
A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear. We propose an explanation of the cause and effect of the twitching and its role in the functioning of ...
This disclosure describes an apparatus to improve the web growth attainable from prior web growth configurations. This apparatus modifies the heat loss at the growth interface in a manner that minimizes thickness variations across the web, especially regions of the web adjacent to the two bounding dendrites. In the unmodified configuration, thinned regions ...
Energy Citations Database
DOE Information Bridge
To improve the efficacy and bioacceptability of polyamidoamine (PAMAM) in potential biomedical applications, the PAMAM dendrimers (first generation) were partially modified with cholic acid. (1)H NMR studies and acid-base titration show that two cholic acid molecules are linked to one PAMAM. The modified PAMAM dendrimers self-assemble to form ...
A new example of an exponential signal amplification strategy for the direct detection of fluoride is demonstrated. The amplification occurred through reaction of fluoride with a responsive chromogenic probe. The probe activity is based on a unique dendritic chain reaction that generates a fluoride anion, which is the analyte of interest, during the disassembly pathway of the ...
Chronic restraint stress (CRS) induces the remodeling (i.e., retraction and simplification) of the apical dendrites of hippocampal CA3 pyramidal neurons in rats, suggesting that intrahippocampal connectivity can be affected by a prolonged stressful challenge. Since the structural maintenance of neuronal dendritic arborizations and synaptic connectivity ...
It is important that zinc electrode should be modified to have a long life. Zinc electrode can be degraded by the formation of dendrite deposit and passive layer on the zinc. The additives prevent zinc electrode from the deposition and deformation during ...
Several models of cortical development postulate that a Hebbian process fed by spontaneous activity amplifies orientation biases occurring randomly in early wiring, to form orientation selectivity. These models are not applicable to the development of retinal orientation selectivity, since they neglect the polarization of the retina's poorly branched early dendritic trees and ...
Monosodium glutamate was administered subcutaneously to male neonate rats, and the effects on cell number and cytoarchitecture of third-layer pyramidal neurons from the prefrontal cerebral cortex were studied in the adult. Monosodium glutamate treatment (4 mg/g of body weight, on post-natal days 1, 3, 5 and 7) resulted in fewer neurons, and shorter and less ramified dendritic ...
We present a novel high-gain patch antenna utilizing composite right-left handed (CRLH) structure and dendritic cell metamaterials. The proposed CRLH antenna, composed of modified Sievenpiper mushroom unit-cells, is based on the positive first-order resonance mode for high gain. In addition, the dendritic cell metamaterials are used to ...
Pyramidal neuron dendrites express voltage-gated conductances that control synaptic integration and plasticity, but the contribution of the Ca(2+)-activated K(+)-mediated currents to dendritic function is not well understood. Using dendritic and somatic recordings in rat hippocampal CA1 pyramidal neurons in vitro, we analyzed the ...
The growth of dendrites during the solidification of thin metallic films has been modeled using the phase-field method, with appropriate boundary conditions to take into account wetting effects. The model was applied to the growth of zinc dendrites during the solidification of hot-dipped coatings of steel, and the simulation results were compared to recent ...
Activity-dependent dendritic Ca2+ signals play a critical role in multiple forms of non-linear cellular output and plasticity. In thalamocortical neurons, despite the well-established spatial separation of sensory and cortical inputs onto proximal and distal dendrites respectively, little is known about the spatio-temporal dynamics ...
Two series of dendritically modified tryptophan derivatives have been synthesised and their emission spectra measured in a range of different solvents. This paper presents the syntheses of these novel dendritic structures and discusses their emission spectra in terms of both solvent and dendritic effects. In the ...
... BUOYANT CONVECTION IN DENDRITIC SOLIDIFICATION D. CANRIGHT SH DAVIS ... BUOYANT CONVECTION IN DENDRITIC SOLIDIFICATION ...
Very large grains, termed �spangles,� are produced on galvanized sheet steel coatings when lead is added to the zinc bath. The spangles have been attributed to melt undercooling prior to solidification. The present results indicate this is not the case, undercooling being less than 1 �C. The spangle diameter is shown to be dependent on the alloy addition to the bath, large spangles being ...
Purpose: To analyze the cytoarchitectural characteristics of the remaining pyramidal neurons in the hippocampal CA1 subfield of rats, four months after global cerebral ischemia (GCI) and progesterone treatment. Methods: Dendritic arborization, and density and shape of the dendritic spines of CA1 pyramidal neurons in brains of intact rats, or rats submitted ...
Columnar dendritic grains of steel growth in the presence of fluid flow (e.g., solidified on turning rolls) have been characterized by Electron Backscattered Diffraction (EBSD) technique. It is shown that grains have a random crystallographic orientation at the surfaces of the sheet in contact with the mould. In the middle of the sheet, the grains which have survived the ...
Commissural interneurons (CINs) help to coordinate left-right alternating bursting activity during fictive locomotion in the neonatal mouse spinal cord. Serotonin (5-HT) plays an active role in the induction of fictive locomotion in the isolated spinal cord, but the cellular targets and mechanisms of its actions are relatively unknown. We investigated the possible role of serotonin in ...
Mutations in presenilins are the major cause of familial Alzheimer's disease (FAD), leading to impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Presenilins are the catalytic subunits of ?-secretase, which itself is critically involved in the processing of amyloid precursor protein (APP) to release neurotoxic amyloid? (A?). Besides A? generation, there is ...
To establish dendritic arbors that integrate properly into a neural circuit, neurons must rely on cues from the local environment. The neurons presynaptic to these arbors, the afferents, are one potential source of these cues, but the particular dendritic features they regulate remain unclear. Retinal bipolar cells can be classified by the type of ...
Spontaneous spreading depolarizations (SDs) occur in the penumbra surrounding ischemic core. These SDs, often referred to as peri-infarct depolarizations, cause vasoconstriction and recruitment of the penumbra into the ischemic core in the critical first hours after focal ischemic stroke; however, the real-time spatiotemporal dynamics of SD-induced injury to synaptic circuitry in the penumbra ...
This work investigated the thermoelectric magnetic convection (TEMC) during directional solidification under a transverse magnetic field numerically and experimentally. Numerical results show that the TEMC will form in liquid near the liquid/solid interface and in the dendritic network. The value of the TEMC mainly depends on the crucible diameter, the temperature gradient, ...
In this paper, dendritic gold nanostructure (DenAu) modified electrode was obtained by direct electrodeposition of planar electrode into 2.8 mM HAuCl(4) and 0.1 M H(2)SO(4) solution under a very negative potential of -1.5 V. Scanning electron microscopy was used to characterize the growth evolution of DenAu with time. The whole DNA biosensor fabrication ...
As the nervous system develops, there is an inherent variability in the connections formed between differentiating neurons. Despite this variability, neural circuits form that are functional and remarkably robust. One way in which neurons deal with variability in their inputs is through compensatory, homeostatic changes in their electrical properties. Here, we show that neurons also make ...
A zircon refractory zirconium silicate was surface melted with a pulsed YAG laser to introduce AlN nanoparticles, with the aim of improving its surface density and modifying the corresponding microstructure. The microstructure and phase structure features of the refractory induced by the laser beam were studied by scanning transmission microscopy, incorporating energy ...
The design of macromolecules able to generate a stable binding with nucleic acids is of great interest for their possible application in gene delivery. During the last years particular attention has been addressed to the use of dendritic scaffolds as a base to construct efficient DNA and siRNA nano-carriers. Dendrimers and dendrons are hyperbranched polymers characterized by a ...
The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-Stk25-Golgi matrix protein 130 (GM130) signaling pathway. ...
�Dendritic valley networks� and broad �longitudinal valleys� are widespread within the eastern Libya Montes region. The morphologic characteristics of the studied dendritic valleys, especially their occurrence at local summits, provide evidence for the initial formation by surface runoff due to atmospheric precipitation whereas the longitudinal ...
Dendritic cells are the most potent subset of antigen presenting cells. They are derived from bone marrow stem cells and reside in peripheral tissues or blood. Upon exposure to antigens and cytokines the peripheral DC s, express high amounts of peptide-MHC, and upregulate their costimulatory molecules, migrate to draining lymph nodes, and interact with T cells to stimulate or ...
Scanning probe lithography (SPL) has recently been shown to be a versatile technique for patterning semiconductor surfaces. The intense electric field emanating from the scanning probe tip can be used for the patterning of carbon- based self-assembled monolayers and thin films, as well as the anodization or field-enhanced oxidation of passivated metal surfaces. We have been investigating the use ...
The discovery of autoantigen clustering in blebs at the surface of apoptotic cells boosted research on the role of apoptosis in systemic lupus erythematosus (SLE) and led to the discovery of autoantigen modification during apoptosis. Normally, apoptotic cells are cleared efficiently and swiftly. However, it became clear that in SLE insufficient removal of apoptotic material leads to the release of ...
... Title : Dendritic Materials Systems. ... Abstract : The research activities of our MURI focused on the use of dendritic polymers in materials applications. ...
backpropagation, that converts cell output from tonic to burst discharge. Through in vitro recordings and com-node bifurcation sepa- rates tonic and burst discharge in pyramidal cells (Doiron et al. Address for reprint. A second objective was to identify the mechanism by which pyramidal cells can switch from a tonic to burst
E-print Network
The surface properties of copper-refractory metal (CU-RF) alloy bodies are modified by heat treatments which cause the refractory metal to form a coating on the exterior surfaces of the alloy body. The alloys have a copper matrix with particles or dendrites of the refractory metal dispersed therein, which may be niobium, vanadium, tantalum, chromium, ...
a method modified from Wolf (1982) (Midkiff et al., 1987). Furosemide (total dose of 10 mg/kg) or isotonic loss of at least 18 gm in furosemide-injected rats and no more than 6 gm for controls. Detailed of animals. Furosemide-treated animals (n 4) excreted 3.59 66 mmol Na per kilogram of body weight during
The anatomical relationships between endorphinic neurons and dopaminergic neurons were evaluated in the rat hypothalamus using a combination of immunocytochemistry and autoradiography. In the arcuate nucleus, endorphinic endings were seen making contacts with dopaminergic cell bodies and dendrites. No synapsis could be observed at the sites of contacts. These results strongly ...
Nb-10 a/o Si alloy is an in-situ composite. The microstructure of the cast alloy consists of pro-eutectic Nb dendrites distributed in a matrix of eutectic Nb3Si + Nb phases. The microstructure of the as-cast alloy was modified by multiple hot extrusions p...
We have hypothesized that intra-tumoral injection of immature DCs should result in acquisition of tumor antigens at the site of injection followed by migration to lymph node and spleen. Here we have used adenoviral vectors, able to efficiently infect both...
