... Title : ACAM2000(TM): The New Smallpox Vaccine for United States Strategic National Stockpile. Descriptive Note : Electronic preprint. ...
DTIC Science & Technology
... Complete List of Vaccines Licensed for Immunization and Distribution in the US. -. Smallpox (Vaccinia) Vaccine, Live. -. Product. ACAM2000 ...
Center for Biologics Evaluation and Research (CBER)
... For this reason, attentively caring for the vaccination site is important to prevent ... It is very important for the ACAM2000 recipient to properly care for the ...
Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax(Registered) (Wyeth Labora...
National Technical Information Service (NTIS)
... 45% of vaccine recipients.47,48 A BFP syphilis test result also occurs in many individuals with autoimmune disorders such as lupus, or infections ...
... 5.11 Blood and Organ Donation Blood and organ donation should be avoided ... pain and swelling) and constitutional symptoms (fatigue, malaise, feeling hot, rigors ...
Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax� (Wyeth ...
PubMed Central
Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax (Wyeth Laboratories, Inc.), was highly ...
PubMed
The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that disseminate to distal sites. We have investigated the immunologic ...
Smallpox vaccines based on replicating vaccinia virus are known to elicit rare yet serious adverse events, particularly in human populations with immune deficiency, atopic dermatitis and at the extremes of age. A vaccine that induces protective immune responses equivalent to first-generation smallpox ...
We still face a threat of orthopoxviruses in the form of biological weapons and emerging zoonoses. Therefore, there is a need to maintain a comprehensive defense strategy to counter the low-probability, high-impact threat of smallpox, as well as the ongoing threat of naturally occurring orthopoxvirus disease. The currently licensed live-virus smallpox ...
... We have reviewed your submissions describing how you will implement education, adverse event reporting, and risk management evaluation for vaccination of ...
... Smallpox Vaccination is Not Associated with Infertility in A Healthy Young ... Smallpox vaccination is not associated with infertility in a healthy ...
Although a highly effective vaccine against smallpox, vaccinia virus (VV) is not without adverse events, some of which can be life-threatening, particularly in immunocompromised individuals. We have recently demonstrated that the immunogenicity and protective efficacy of Dryvax(�) in immunocompetent mice is preserved even when co-administered with ...
... Title : TITRATION OF SMALLPOX VACCINES FROM TEN COUNTRIES SENT TO EAST PAKISTAN DURING THE 1958 SMALLPOX EPIDEMIC. ...
Page 1. Naval Health Research Center Smallpox Vaccination. ... Smallpox Vaccination Comparison of Self-Reported and Electronic Vaccine Records ...
Highly attenuated modified vaccinia virus Ankara (MVA) is being considered as a safer alternative to conventional smallpox vaccines such as Dryvax or ACAM 2000, but it requires higher doses or more-frequent boosting than replication-competent Dryvax. Previously, we found that passive transfer of A27 antibodies can ...
Smallpox is a contagious disease caused by a virus. Smallpox virus has been eradicated worldwide through successful vaccination ...
MedlinePLUS
... Title : Smallpox Vaccination. Comparison of Self-Reported and Electronic Vaccine Records in the Millennium Cohort Study. ...
... Accession Number : ADA519633. Title : Smallpox Vaccination is Not Associated with Infertility in a Healthy Young Adult Population. ...
... Title : Duration of Viremia Following Vaccination and Smallpox. Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD. ...
... Smallpox as a naturally occurring disease was eradicated after a world-wide vaccination campaign; however, the threat that smallpox or a related ...
This publication discusses the risk of a bioterrorist attack involving smallpox and related viruses. It lists likely countermeasures and explains the disadvantages of vaccination. Also discussed are future needs for smallpox preparedness.
E-print Network
... Smallpox patients are most infectious during the first week of the rash when the oral mucosa lesions ulcerate and release substantial amounts of virus into the ...
SVP Status: 2 million+ people vaccinated with smallpox vaccine since Dec 02 NOTICE: Cardiac Adverse Events Safety Summary to Date SVP Online Proficiency Training DoD Smallpox...
Science.gov Websites
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM General...result of the administration of the smallpox vaccine or other covered countermeasure, and...certain persons vaccinated with the smallpox vaccine or with ...
Code of Federal Regulations, 2010
vaccine. The smallpox vaccine is used for this disease. Mumps Pertussis Pneumococcal Polio Rabies Rotavirus Rubella Shingles (Herpes Zoster) Smallpox Tetanus Typhoid...
... Food; Drugs; Medical Devices; Vaccines, Blood & Biologics; Animal & Veterinary; ... Vaccine (from FDA's Center for Biologics Evaluation and Research); Smallpox Vaccine ...
Center for Drug Evaluation (CDER)
... at their disposal either effective specific prophylactic preparations (diphtheria :natoxin, smallpox vaccine, vaccines for poliomyelitis and whooping ...
In response to threats of bioterrorism, US military personnel began receiving smallpox vaccinations in 2003. Although some adverse health effects associated with smallpox vaccination are well described, much less has been documented about reproductive hea...
This document describes the logistical considerations for voluntary, large-scale, post-event smallpox vaccination clinics. This example model may be used to supplement other state and local vaccination planning considerations for responding to a smallpox ...
... smallpox vaccine in preventing monkeypox? Past data from Africa suggests that the smallpox vaccine is at least ... and severe rash. Studies of monkeypox in West Africa�where people live in remote areas and are ...
Background: Little information is available to describe the risks of smallpox vaccine administered in pregnancy, with the exception of known, rare cases of fetal vaccinia. When the United States implemented a smallpox vaccination program in 2003, the Smal...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Calculation...its health complications if the smallpox vaccine recipient or vaccinia contact lost...the lost work days based on the smallpox vaccine recipient or vaccinia contact's...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Required...documentation requirements for smallpox vaccine recipients), in the case of a deceased smallpox vaccine recipient. The survivor requester...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Required...In order to establish that a smallpox vaccine recipient or vaccinia contact sustained...countermeasure (including the smallpox vaccine) or vaccinia contracted through...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures...who are survivors. If a smallpox vaccine recipient or vaccinia contact...sought by the estate of a deceased smallpox vaccine recipient or vaccinia contact....
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures...whether the injured individual is a smallpox vaccine recipient or a vaccinia contact...under this Program. (c) Smallpox vaccine recipients. All Request Forms...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures...private courier service. The Smallpox Vaccine Injury Compensation Program Office will...forms and documentation to the Smallpox Vaccine Injury Compensation Program...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures...forms and instructions to the Smallpox Vaccine Injury Compensation Program Office...forms and instructions to the Smallpox Vaccine Injury Compensation Program...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Available... (a) Requesters who are smallpox vaccine recipients or vaccinia contacts...income to the estate of a deceased smallpox vaccine recipient or vaccinia contact as...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Persons...the Secretary determines that a smallpox vaccine recipient or vaccinia contact died...this Program must be a deceased smallpox vaccine recipient or vaccinia contact who...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Persons...from this Program: (1) Smallpox vaccine recipients, as described in § 102.3...Representatives of the estates of deceased smallpox vaccine recipients or vaccinia contacts...
... Smallpox Vaccine, Dried, Calf Lymph Type. -. Product. Dryvax Wyeth Pharmaceuticals, Inc. -. Contact Us. Consumer Affairs Branch (CBER). ...
... the smallpox vaccine. Those who are pregnant or nursing. Children younger than 12 months of age. Those who have a heart condition such as chest pain, history of heart attack or stroke, congestive heart failure ...
... Accession Number : ADA426748. Title : Smallpox DNA Vaccine Protects Nonhuman Primates Against Lethal Monkeypox. ...
... Title : Smallpox DNA Vaccine Delivered by Novel Skin Electroporation Device Protects Mice Against Intranasal Poxvirus Challenge. ...
... may carry a lifetime risk since, in past vaccination programs, even people with normal skin but a history of eczema in childhood sometimes developed eczema vaccinatum. ...
smallpox experience, dermatologists, ophthalmologists, pathologists, surgeons, anesthesiologists in facilities where intensivists [i.e., physicians who are board-certified in a...
... with serious complications, such as those affecting the heart, brain, and skin ... "Development of a highly efficacious vaccinia-based dual vaccine against smallpox ...
... hour history of pain, tenderness, swelling, and erythema over her left anterior chest wall nine days after receiving a primary smallpox vaccination. ...
... Dryvax Smallpox Vaccine, Dried, Calf Lymph Type, Labeling Supplement: Include additional language regarding skin lesions at the smallpox vaccination site, 101106 ...
to an epidemic � Mass vaccination � Targeted vaccination � Quarantine � Focus on smallpox #12;5 Smallpox � Acute eradicated the disease #12;6 Smallpox � Concern that smallpox could be used in a terrorist attack � U.S. government has stockpiled 300 million ...
infected with cowpox did not get smallpox. In 1796 he started vaccinating people with cowpox to protect published, and by the early 1800s, the smallpox vaccine was widely available. Smallpox vaccination was used involved extensive vaccination programs ...
Amid growing concerns about a potential smallpox attack, the Centers for Disease Control and Prevention (CDC) is working with 62 state, local, and territorial jurisdictions to implement the civilian part of the National Smallpox Vaccination Program. The g...
... titration on tissue cultures) of the virus of the smallpox vaccine (strain No 3 of the dermovaccine of the Institute of Embryology and Microbiology im. ...
... Title : INVESTIGATION OF THE POSSIBILITY OF ORAL IMMUNIZATION OF EXPERIMENTAL ANIMALS WITH THE SMALLPOX VACCINE VIRUS. ...
...smallpox vaccine recipient or vaccinia contact must submit to be deemed eligible by the...smallpox vaccine recipient or vaccinia contact must submit to be deemed eligible by the...smallpox vaccine recipient or vaccinia contact must submit the following...
...2010-10-01 false Documentation a smallpox vaccine recipient must submit to be deemed eligible...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Required...102.51 Documentation a smallpox vaccine recipient must submit to be deemed...
Smallpox has been eradicated but stockpiles of the causative infectious agent, variola virus, have been maintained over decades. Today, the threat of accidental or intentional poxvirus release is accompanied by the fact that the existing licensed smallpox vaccines cause rare but severe adverse reactions yet are the only products with ...
Tracking vaccine reactions and adverse events during a large-scale vaccination program such as the recent smallpox program or a pandemic flu outbreak will be a challenge. We report on vaccine reaction data collected using a novel telephone- and web-based ...
... for these vaccines addressed the characterization of the seed virus, the production process in calves or embryonated chicken eggs, and the testing process (eg ...
... such as a nonhuman primate with a particular orthopox virus delivered by ... of vaccines for smallpox, anthrax, botulism, plague, tularemia, or Ebola and each ...
... Title : Policies for Biodefense Revisited: The Prioritized Vaccination Process for Smallpox. Descriptive Note : Technical rept. ...
... In addition, data on the natural history of smallpox vaccination arc dated, as the US has not routinely vacci nated civilians against smallpox since ...
... Title : Report of the Defense Science Board Task Force on Smallpox Vaccine Down Select Process Report Summary. Descriptive Note : Final rept. ...
Smallpox was a devastating disease caused by the orthopoxvirus Variola virus. The naturally occurring disease was eradicated 25 years ago, enabling cessation of smallpox vaccination (with the orthopoxvirus Vaccinia virus) worldwide.
Eradication of the smallpox virus through extensive global vaccination efforts has resulted in one of the most important breakthroughs in medical history, saving countless lives from the severe morbidity and mortality that is associated with this disease. Although smallpox is now extinct in nature, laboratory stocks of this virus still ...
... Index What We Learn About Smallpox from Movies - Fact or Fiction Over the years, the writers of ... cdc.gov/agent/smallpox/prep/cdc-prep.asp . Facts about Isolation and Vaccination Strategy: How Public Health ...
. . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5.2 Smallpox Vaccination Clinic with Surge and Exponential Arrival . . . . . . . . . . . . . . . . . . . . . . 13 5.3 Second Smallpox situation, such as anthrax or smallpox being introduced into a population as a bioterrorist act
The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subuni...
... for coronary artery disease known in their medical history. The 5 patients had illness onset from 4 to 17 days after vaccination. It is not known at this time if ...
Work has begun in the testing of 4 smallpox vaccines in various dilutions by percutaneous and subcutaneous routes. One hundred seventy-two children have been given coded percutaneous vaccine with successful observations and 28-day serologic sampling of ab...
In December 2002, the US Government implemented policy to immunize health workers, first responders and military personnel against smallpox in preparation for a possible bioterrorist attack. Self-reported vaccination data are commonly used in epidemiologi...
The study is designed to determine whether differences in the strain of vaccinia virus used for vaccination against smallpox, its concentration over a three log range, or whether it is administered percutaneously or subcutaneously, will have a salutory ef...
Two decades after a worldwide vaccination campaign was used to successfully eradicate naturally occurring smallpox, the threat of bioterrorism has led to renewed vaccination programs. In addition, sporadic outbreaks of human monkeypox in Africa and a rece...
The aim of this paper is to discuss the emergence and establishment of a "culture of immunization" in the contemporary Brazil from the eradication of smallpox. This culture is associated with a long process of introduction of vaccines, vaccination campaigns and mass vaccination undertaken by the Brazilian ...
In January 2003, the Secretary of the US Department of Health and Human Services (DHHS) announced that certain individuals should receive smallpox vaccine or other countermeasures to be prepared to serve the civilian population in the event of a smallpox bioterrorism event. In April 2003, Congress passed and the President signed the ...
Following the terrorist attacks on 11 September 2001 there has been increased concern about bioterrorism, much of it focused on smallpox. Routine smallpox vaccination in the USA was discontinued in 1972 and most US citizens are susceptible to smallpox. The last natural case of smallpox occurred ...
In December 2002, the Department of Defense re-instituted smallpox vaccination for US military forces following growing concerns that smallpox might be employed as a bioterrorist weapon. More than one million service members have been given the smallpox v...
Few diseases can match the enormous impact that smallpox has had on mankind. Its influence can be seen in the earliest recorded histories of ancient civilizations in Egypt and Mesopotamia. With fatality rates up to 30%, smallpox left its survivors with extensive scarring and other serious sequelae. It is estimated that smallpox killed ...
... 8.0 Task 8 - Levels of Neutralizing Antibodies to Vaccinia Following Vaccination against Smallpox ... Implication for the New Hepatitis A Vaccines ...
formulation. Smallpox has a definite short prodromal period before the symptoms emerge when the infected of vaccination began with Edward Jenner in 1796 who developed a vaccine against smallpox--which remains the only are protected. Some vaccines can have adverse side effects; the ...
Smallpox is an acute infectious disease caused by the variola virus. Smallpox is believed to have emerged in human populations about 10,000 BCE A description of smallpox first appeared in a Chinese text in the 4th century. The name variola was first used during the 6th century and is a derivative of the Latin varius, meaning spotted, ...
The first protection against smallpox, a disease known already in old China and India, consisted in rubbing infectious material from smallpox patients into the scratched skin of children. Lady Montagu brought this method from Turkey to England in 1721. This "variolation", however dangerous, was adopted in Europe during the eighteenth century mainly by the ...
Presently, there is no real possibility of natural re-emergence of smallpox virus, which was eradicated globally more then 25 years ago. During the last decade the possibility of use of smallpox virus as a biological weapon by a criminal organisation was emphasised. The re-emergence of smallpox virus would lead to unprecedented ...
The eradication of smallpox, one of the great triumphs of medicine, was accomplished through the prophylactic administration of live vaccinia virus, a comparatively benign relative of variola virus, the causative agent of smallpox. Nevertheless, recent fears that variola virus may be used as a biological weapon together with the present susceptibility of ...
Medical countermeasures to prevent or treat smallpox are needed due to the potential use of poxviruses as biological weapons. Safety concerns with the currently available smallpox vaccine indicate a need for research on alternative poxvirus vaccine strate...
or 30 days before receiving anticipated smallpox vaccination. _______ POLIO (oral or IM) (As an adult days before receiving anticipated smallpox vaccination. _______ POLIO (oral or IM) (As an adult, once
Myopericarditis has been a rare or unrecognized event after smallpox vaccinations with the New York City Board of Health strain of vaccinia virus (Dryvax; Wyeth Laboratories, Marietta, Pennsylvania). In this article, the authors report an attributable inc...
The guidance in this report is for evaluation and treatment of patients with complications from smallpox vaccination in the preoutbreak setting. Information is also included related to reporting adverse events and seeking specialized consultation and ther...
A live smallpox virus administered perorally to experimental animals (monkeys, rabbits and guinea pigs) induced immunological changes (a rise in the antihemagglutinin titers and virus-neutralizing antibodies). Simultaneously, there was an increase of cuta...
Smallpox vaccine-associated myopericarditis may have a similar presentation to acute coronary syndrome (ACS). The clinical records of 78 young patients.
The presenter explains how medical prophylaxis can minimize the impact of biological attacks. He looks at smallpox vaccination and possible complications in particular. He concludes with a summary of Czech vaccination policy for smallpox and anthrax.
...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Calculation and Payment...are reasonable and necessary to diagnose or treat a smallpox vaccine recipient or vaccinia contact's covered injury or its...
...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...
...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM General Provisions ...survivors if the Secretary determines that the death of the smallpox vaccine recipient or vaccinia contact was the direct result of a...
On December 13, 2002, President Bush announced a strategy to better protect Americans against the threat of smallpox attack. This Web site from the Department of Health and Human Service (DHHS) offers a comprehensive resource for information on smallpox, aiming at an audience of healthcare professionals, medical researchers, and the general public. ...
NSDL National Science Digital Library
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication
... Indications: treatment and/or modification of the following conditions, which are complications resulting from smallpox vaccination: ...
... Hospitalizations for asthma, autoimmune diseases, and myopericarditis, were more likely in the postvaccine group. The ...
Smallpox was officially declared eradicated from the world in 1980. Earlier, in 1972, over 50 nations signed the Biological Weapons Convention renouncing this entire category of weapons. Despite this international agreement, both the United States and the Soviet Union continue to vaccinate their military troops against smallpox, thus ...
... Using these data, adverse reproductive health outcomes are assessed, including birth defects, pregnancy loss, and infertility among military ...
... agents Ricin Q & A Health Professionals Labs Responders Sarin Saxitoxin Selenium Sodium azide Sodium monofluoroacetate Soman Strychnine ...
... As a result of different investigations with inactivated small-pox vaccine in human volunteers, a delayed hypersensitivity test of the skin was ...
... In considering that the number of foreign sailors who reacted positively to small pox vaccination was almost 3 times greater than that of Soviet ...
... not exist for many of the biological threats deemed the most dangerous by the ... HHS recognizes a need for better vaccines for anthrax and smallpox ...
... mil). Clinical Infectious Diseases 2008;46:000�000 This article is in the public domain, and no copyright is claimed. 1058 ...
... Puritan preacher Cotton Mather had in getting some in Boston vaccinated against smallpox in 1721 and in prosecuting the Salem witch trials in the 1680s. ...
NASA Website
... Return to Table of Contents. APPENDIX: MODERATE AND SEVERE COMPLICATIONS OF SMALLPOX VACCINATION AND INADVERTENT VACCINIA VIRUS INFECTION. ...
... Traditional vaccines have been used effectively for the last fifty years, in some cases eliminating diseases such as smallpox and polio. ...
... Title : COMPLEX IMMUNIZATION OF GUINEA PIGS WITH LIVE VACCINES AGAINST PLAGUE, SMALLPOX AND YELLOW FEVER AND WITH ...
... mesenteric (54%) and tracheobronchial (46%) lymph nodes, meninges (38%), lungs (31%) and ... meningitis (77%), hemorrhages in the meninges ...
... Effects of smallpox vaccination on skin reaction and serum antibody response in naval recruits; Fractionation of cold agglutinins for use in ...
This investigation focuses on potential long term negative health consequences of smallpox vaccination in military personnel who were on active duty in December 2002 when DoD implemented a service-wide smallpox vaccination program. It is designed to compl...
...DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM ...days) of work missed by the smallpox vaccine recipient or vaccinia contact as...used paid leave); (b) The smallpox vaccine recipient or vaccinia contact's...
SUMMARY: In histories of smallpox and vaccination, little attention has been paid to their progress in the southern latitudes. In this paper, I focus on the appearance of smallpox around Sydney Cove in 1789 and the introduction of cowpox (vaccine) to New South Wales in 1804. I demonstrate the connections, ...
New stockpiles of smallpox vaccine are required as a contingency for protecting civilian and military personnel against deliberate dissemination of smallpox virus by terrorists or unfriendly governments. The smallpox vaccine in the current stockpile consists of a live animal poxvirus (Vaccinia ...
Smallpox, when used as a biological weapon, presents a serious threat to civilian populations. Core components of the public health management of a terrorism attack using smallpox are: vaccination (ring vaccination and mass vaccination), adverse event monitoring, confirmed and suspected ...
Through an examination of mass BCG vaccination against tuberculosis in India between 1948 and 1960 this article draws attention to the diversity of the history of vaccination. The features of vaccination campaigns often differed from those of the celebrated campaign to eradicate smallpox. Due to differences between ...
From the perspective of historiography, the article analyzes the construction of scientific medicine's major landmark: the small-pox vaccine. When this vaccine was created and widely distributed, the medical field demonstrated how technology controls life on a planetary scale. The great victory of scientific medicine rests on the fact ...
... Called health pro. to get info about anthrax vaccine Called health pro. to get info about smallpox vaccine Purchased a weapon ...
... licensed anthrax vaccine, BioThrax, in protecting mice and rabbits against anthrax�it was also safer in immune ...
theory to explain the relation between group interest and self-interest in smallpox vaccination policy. Such shortfall resulted in a substantial increase in expected mortality after an attack of smallpox. Vardavas et of smallpox on real world social networks under voluntary vaccination, where ...
The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) supported a reorientation of research in tropical medicine after the Second World War, in the direction of virus research, by financing relevant research projects and the establishment of entire departments, or by guaranteeing the subsistence of institutes. During the post-war period research was focussed on the ...
As an initial step in the development of a second-generation smallpox vaccine derived from the Lister strain, to be prepared for a variola virus threat, diversity of the traditional vaccine was examined by characterizing a series of ten viral clones. In vitro and in vivo phenotypic studies showed that the biological behavior of the ...
Despite the eradication of smallpox several decades ago, variola and monkeypox viruses still have the potential to become significant threats to public health. The current licensed live vaccinia virus-based smallpox vaccine is extremely effective as a prophylactic vaccine to prevent orthopoxvirus infections, but ...
In repeated tests statically authentic data were obtained concerning the ability of rivanol, proflavin and acrichine to fully suppress the development of the hemagglutinins of virus of smallpox and also the development of visible affections in the chorioa...
Smallpox virus is considered one of the most significant threats for use as a biowarfare agent. Due to complications from vaccination, mass immunization of the populace is contra-indicated. Our current research seeks to develop effective anti-poxvirus dru...
exposure to smallpox? � How dangerous is the fallout from a dirty bomb? � Can I trust the schools the anthrax mailings, the D.C. sniper attacks and the abortive smallpox vaccination campaign -- indeed, after
The experiments repeatedly demonstrated the survival of vaccinia virus in the blood long after the disease process had stopped, including one case of smallpox. If one assumes that an infectious disease is an ecological process aimed not at the destruction...
increase. The eradication of smallpox, announced in 1980, spelled the end of a vaccination program that had by squirrels and other rodents. (Although generally less lethal than smallpox, monkeypox can cause serious
Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home Centers for Disease Control...
The release of smallpox virus by bioterrorists remains a serious threat. The United States government believes some nations may still possess undeclared stocks of the virus and the legacy of the massive Soviet bioweapons program poses the particular risk ...
Proof-of-concept studies suggest that current defences against smallpox could be strengthened by supplementing vaccination with antiviral drug prophylaxis, based on aerosolized or orally available forms of the long-acting medication cidofovir. Delivery of...
The article presents epidemiological situation of smallpox in them world and in Poland. On the basis of registered numbers of cases, as well as estimated numbers of complications problem of vaccination programs is analyzed. Strategy of general vaccination of children vs. Vaccination of risk groups is discussed. ...
In complex immunization the vaccination reactions were caused mainly by TAVTe vaccine; when administered simultaneously with other preparations, tickborne encephalitis, BCG and influenza vaccines did not augment the reaction-producing characteristics of t...
Persistence of vaccinia at vaccination sites may help determine the risk associated with secondary transmission. Culture, PCR, and antigen detection were performed on serial vaccination site swab specimens. On day 21 after vaccination, 37% of volunteers w...
Post-vaccinal encephalitis, although relatively uncommon, is a known adverse event associated with many live, attenuated smallpox vaccines. Although smallpox vaccination ceased globally in 1980, vaccine manufacture has resumed in response to concerns over the possible use ...
BackgroundPrevious smallpox ring vaccination models based on contact tracing over a network suggest that ring vaccination would be effective, but have not explicitly included response logistics and limited numbers of vaccinators.MethodsWe developed a continuous-time stochastic simulation of ...
Several dates of memory from the history of the vaccination against smallpox are to be registered for the year 1990. The birthday of the vaccination propagandist Johann Adam Reimann comes round the 300th time, the initial date of relevant university instructions comes round the 200th time. Issuing from this the history of ...
In updated recommendations, a Centers for Disease Control and Prevention advisory committee says that a small group of predesignated personnel should receive smallpox vaccinations, but not the general public or other health care workers. Some managers insist that any group who could be exposed without advance notice should be ...
During the complex immunization of guinea pigs with live vaccines against plague, smallpox and yellow fever and also killed vaccine against cholera in various combinations, no suppression was noted in the effectiveness of any of the antigens used. During ...
�49 years) on the basis of prior history of vaccine exposure. Exclusion criteria for vaccination are noted exclusion criterion for cohort N: � Presence of a typical vaccinia scar or history of smallpox vaccination724 � JID 2005:191 (1 March) � Shaklee et al. M A J O R A R T I C L E ...
One concern with traditional smallpox vaccination is inadvertent spread of virus to atopic or immunocompromised contacts. To reduce this risk, we tested the ability of povidone iodine to inactivate infectious virus at the vaccination site beginning at 7 days after transcutaneous smallpox ...
This article seeks to understand the discursive context of the cessation of routine smallpox vaccination in the United States in the early 1970s. The United States has a long tradition of opposition to compulsory smallpox vaccination, usually expressed in terms of concerns about personal liberties, the extent of ...
Abstract As healthcare institutions are a focus of smallpox transmission early in an epidemic, several mathematical models support pre-event smallpox vaccination of healthcare workers (HCWs). The deciding factor for HCW voluntary vaccination is the risk of disease exposure versus the risk of ...
Energy Citations Database
After the recent summary of World Health Organization-authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the cause of the high mortality rate among pregnant women and whether ocular smallpox is ...
This electronic book from the National Academies Press (NAP) presents recommendations to the Centers for Disease Control (CDC) from the Committee on Smallpox Vaccination Program Implementation. The committee -- members of the Board on Health Promotion and Disease Prevention, Institute of Medicine -- focuses on two main issues: Considerations for next steps ...
Liquid smallpox vaccine inactivated by gamma irradiation proved to be fully adequate for studying the effects of gamma irradiation on the viability of microorganism artificially added to it. The complete inactivation of Staphylococcus albus and Bacillus subtilis, which most frequently contaminate smallpox ...
BACKGROUND: Women serving in the US military have some unique occupational exposures, including exposure to vaccinations that are rarely required in civilian professions. When vaccinations are inadvertently given during pregnancy, these exposures raise sp...
Febrile Seizures Rotavirus Vaccine Addressing Common Concerns 2009 H1N1 Flu Adjuvants Autism Fainting (Syncope) Febrile Seizures GBS GBS and Menactra Meningococcal Vaccine FAQs...
for Biodefense and Emerging Infections: Discovery of subunit vaccines for smallpox. This is an independent components for a human smallpox subunit vaccine. 20043520414689: Co-PI =Sykes PI =Bernhard Kaltenboeck 9 for Biomedical Inventions (CBI). � MacroGenics, Inc. Dallas, TX 5/2001-6/2004 Director of ...
In June 2001, the Advisory Committee on Immunization Practices (ACIP) made recommendations for using smallpox (vaccinia) vaccine to protect persons working with orthopoxviruses and to prepare for and respond to a possible terrorist attack involving smallp...
The aim of this paper is to discuss some actions that made possible the eradication of smallpox in Brazil, considering the main contexts and policies adopted for the disease between 1920 and 1970, assuming as contrast educational measures in the field of health and establishing a discussion on the educational content of the programs adopted. It can be observed that, during ...
In 1966, a programme to eradicate smallpox and control measles began in West and Central Africa. With WHO and US bilateral technical and financial assistance, the 20 countries mounted a coordinated campaign of mass vaccination, assessment, surveillance, and maintenance activities. The last cases of smallpox occurred in May 1970. The ...
... Clinical Infectious Diseases 2004;38:1320�2 This article is in the public domain, and no copyright is claimed. 1058-4838/2004/3809-0021 ...
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... Other uses, including reproduction and distribution, or selling or licensing ... 300 Depressive disorder, not elsewhere classified ... 311 Neurotic disorders ...
The World Health Assembly is scheduled to decide in May 2011 whether the 2 known remaining stockpiles of smallpox virus are to be destroyed or retained. In preparation for this, a WHO-appointed committee undertook a comprehensive review of the status of smallpox virus research from 1999 to 2010. It concluded that, considering the nature of the studies ...
, the Federal government's Strategic National Stockpile contains 300 million doses of small-pox vaccines
... harvesting, necropsy Virus from embryonated chicken eggs � Eggs from flocks free of specified ... positive staphylococci, viable bacteria General safety ...
... hepatitis A and B, herpes simplex, chickenpox, smallpox, polio, and yellow fever.1,19,22 Therefore, human ... ...
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... The same entrapment took place in meshes of zilk curd idiean the survival of Brucella in cheese uas studied; the cheese had been made of milk ...
... Title : DoD-Wide Medical Surveillance for Potential Long-Term Adverse Events Associated With Smallpox Vaccination, Hospitalizations, and Self ...
... designed to test the safety and efficacy of more attenuated strains of vaccinia. CBER also helped WRAIR in their smallpox vaccination campaign by testing serum ...
and Exposure Radiation Measurement Radiation Dictionary Fact Sheets Other Resources Radiation and Environmental Health Communication Research Related Links Mass Casualties...
