Coronary Heart Disease; Acute Coronary Syndrome; Impaired Glucose Tolerance; Diabetes Mellitus, Non-Insulin-Dependent

The Objectives of the Study is to Evaluate the Efficacy and Safety of Acarmet (Metformin HCl 500 mg; Plus Acarbose 50 mg Tablets) Thrice Daily Versus Acarbose 50 mg Thrice Daily Over 16 Weeks in; Subjects With Type 2 Diabetes Mellitus.

The prevalence of glucose intolerance is increasing dramatically worldwide. Both impaired glucose tolerance (IGT) and type 2 diabetes are associated with excess mortality from cardiovascular disease. It is now generally accepted that these cardiovascular complications are related to prevailing hyperglycemia, particularly postprandial hyperglycemia. ...

Acarbose is an alpha-glucosidase inhibitor acting specifically at the level of postprandial glucose excursion. This compound lowers HbA(1c) by 0.5-1% in patients with Type 2 diabetes, either drug naive or in combination with other antidiabetic drugs. In those with impaired glucose tolerance (IGT), it reduces the incidence of newly diagnosed diabetes by 36.4%. Furthermore, it ...

The alpha-glucosidase inhibitor acarbose is administered to control blood glucose levels in type 2 diabetic patients and, in several countries, in those with impaired glucose tolerance. The efficacy and safety of the drug has been well established in these patient populations. Acarbose shows no weakening of efficacy in long-term diabetes treatment, reduces ...

Acarbose is an alpha-glucosidase inhibitor which reversibly and competitively inhibits the digestion of oligo- and disaccharides at the brush border of the small intestine. This study evaluates the preventive and therapeutic properties of acarbose in the treatment of obesity. Dose-response experiments were performed during repeated ...

A monocentric, open, randomised, single-dose, six-period crossover trial was carried out in healthy volunteers under fasting conditions to establish the most appropriate study design for a pivotal bioequivalence trial with acarbose (CAS 56180-94-0) regarding a) dosage of the drug, b) type of carbohydrate load, c) type of primary endpoint, and d) sample size. 50 g sucrose or 50 ...

SUMMARYType 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action�potential targets of preventive interventions�are impaired. In trials lifestyle modification (i.e. weight loss and exercise) has proven effective in preventing incident T2DM in high-risk groups, although weight ...

In this article we discuss the available data on the effects of combined therapy of ezetimibe with agents affecting lipid metabolism other than statins. We consider studies evaluating the effects of combined therapy of ezetimibe with bile acid sequestrants, fenofibrate, niacin, n-3 fatty acids, plant sterols, orlistat, metformin, acarbose and glitazones. ...

... and Respiratory Systems: Evaluation of ... and Pulmonary Effects of Pyridostigmine ... (kt). Descriptors : *CARDIOVASCULAR SYSTEM, *DRUGS ...

Cardiovascular electromechanical measurements were collected on returning Skylab crewmembers at rest

1 Electrospinning of Scaffolds for Cardiovascular Tissue Engineering M.H. van Marion 15 July 2005 a systematic evaluation was performed of the functionality of electrospun scaffolds for use in cardiovascular of cardiovascular tissues, such as arteries and heart valves. Currently used ...

1. The aim of the present study was to compare the effects of glipizide controlled-release (CR) tablets monotherapy with that of glipizide CR tablets plus acarbose on glycaemic variability in newly diagnosed Type 2 diabetes (T2DM) patients using a continuous glucose-monitoring system (CGMS). 2. Forty newly diagnosed T2DM patients whose glycated haemoglobin A1c (HbA1c) levels ...

soothing massage and quite acceptable to the recipient. The potential of these devices are evaluated by monitorinq cardiovascular responses. ...

Quality a) The enzyme activity will be studied with colorimetric and spectrofluorimetric methods, while its cardiovascular zonation will be evaluated by ...

Cardiovascular changes induced in animals by prolonged weightlessness, using implanting polyethylene

Three flavonoids from tartary buckwheat bran, namely, quercetin (Que), isoquercetin (Iso) and rutin (Rut), have been evaluated as alpha-glucosidase inhibitors by fluorescence spectroscopy and enzymatic kinetics and have also been compared with the market diabetes healer, acarbose. The results indicated that Que, Iso and Rut could bind alpha-glucosidase to ...

... Acarus siro L. is sensitive to the α-amylase inhibitor of bacterial origin acarbose, which reduced the ... a synergism between the effects of the α-amylase inhibitor acarbose and the predatory mite Cheyle...

Jun 10, 2011 ... Grow Text SizeShrink Text Size. Cardiovascular Responses During Rest and Exercise, and Evaluation of Energy Inputs During Exercise (CCE) ...

... In fact, the acarbose ANDA that included a PD study was the first to be filed, by Cobalt Laboratories in January 2005. Third, it ...

Alpha-glucosidase inhibitors (such as acarbose) decrease the absorption of carbohydrates from the digestive tract, thereby lowering the after- ...

catecholamine which is a precursor in the synthesis of the normal .... evaluate the effects of morphine in acute myocardial infarction ...

OBJECTIVE To investigate whether the dipeptidyl peptidase-4 inhibitor vildagliptin improves endothelium-dependent vasodilatation in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Sixteen subjects with type 2 diabetes (age 59.8 � 6.8 years, BMI 29.1 � 4.8 kg/m(2), HbA(1c) 6.97 � 0.61) on oral blood glucose lowering treatment were included. Participants received vildagliptin 50 mg ...

except glucose. Maltose transport of acarbose-grown cells was inhibited by sucrose and trehalose and, glycerol or maltose. These results suggest that an acarbose-insensitive maltose/sucrose/trehalose that accepts maltose/sucrose/trehalose and is moderately sensitive to acarbose is found in cells grown

The National Institute on Aging Cardiovascular Biology Unit-Vascular Group is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel methods for diagnosing age-related cardiovascular disorders.

Mechanisms involved in human cardiovascular adaption to stress, particularly adaption to different levels of physical activity are determined along with quantitative noninvasive methods for evaluation of cardiovascular function during stess in normal subj...

Ankylosing spondylitis is an inflammatory disorder primarily affecting the axial skeleton. The disease is associated with increased cardiovascular morbidity and mortality. Structural changes in the heart, and arteriosclerosis secondary to inflammation may be of importance. The role of traditional cardiovascular risk factors and of anti-inflammatory ...

Fifty-gram carbohydrate tolerance tests were performed on healthy volunteers to test the activity and specificity of an alpha-glucoside hydrolase inhibitor, acarbose (BAY g 5421). Two hundred milligrams acarbose reduced the area under the blood glucose response curve by 89% (P less than 0.001) after sucrose by 80% (P less than 0.002) after starch, by 19% ...

Inhibition of intestinal ?-glucosidases and pancreatic ?-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases responsible for the final step of starch hydrolysis. Here we compare the inhibition ...

Cardiovascular diseases are the major cause of mortality in Spain. This feature is related with the high prevalence of cardiovascular risk factors, particularly high blood pressure, dyslipidaemia, smoking, obesity and diabetes. Otherwise, the association of several risk factors, all related with cardio-metabolic risk, is the basis for the increase of ...

Cardiovascular diseases are an increasing problem in patients with HIV infection. The causes of the increased cardiovascular risk in HIV-infected patients are multifactorial. Currently, the question of which factor has the most weight in this equation - whether traditional risk factors, the virus per se or antiretroviral therapy - remains to be determined. ...

Heart disease and depression are very common, frequently concomitant, conditions that were previously speculated by the World Health Organization to be the first and second leading causes of disability (respectively) by the year 2020. There have been no secondary prevention of cardiovascular disease trials that have shown treatment of depression reduces ...

In order to evaluate the quality of the cardiovascular adjustments of cardiac patients to exercise, 12 men who had recovered from well-documented episodes of myocardial infarction were evaluated with a work-capacity test while sedentary and after 8 months...

Evaluation of the cardiovascular system is important in determining an individual's ability to tolerate the stresses of flying. The electrocardiogram is an essential part of the cardiovascular evaluation. A case is presented of a USAF pilot of 19 years wh...

The study was conducted to: (1) identify and describe types of health hazard appraisal programs used in industry; (2) characterize the uses and extent to which health hazard appraisal serves as a basis for planning, operating, or evaluating cardiovascular...

Page 1. Guidance for Industry Diabetes Mellitus � Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes ...

... This document reviews the literature on test procedures for determining toxic effects on the heart and other components of the cardiovascular ...

Cardiopulmonary bypass developed for studies of long term weightlessness on cardiovascular system of