... is one of the metabolites of the catecholamines epinephrine (adrenaline) and norepinephrine. Catecholamines are a group of similar ... The primary catecholamines that they release are dopamine, epinephrine, and norepinephrine. These hormones are released into the ...

... Catecholamines, Plasma and Urine Also known as: Dopamine; Epinephrine; Norepinephrine; Free Urine Catecholamines Formal name: Catecholamines, Plasma ... of each kidney. The primary catecholamines are dopamine, epinephrine (adrenaline), and norepinephrine. These hormones are released into ...

1. When animals were exposed to a temperature of 4� C for 6 hr, endogenous catecholamines remained unaltered or reduced slightly depending upon the strain of rats used. In contrast, labelled noradrenaline declined rapidly, but the decline was inhibited when animals were pretreated with monoamine oxidase inhibitors. 2. Increased sympathetic nervous activity associated with ...

... Metanephrines are the inactive metabolites of the catecholamines epinephrine (adrenaline) and norepinephrine. Catecholamines are a group of similar ... of each kidney. The primary catecholamines are dopamine, epinephrine (adrenaline), and norepinephrine. These hormones are released into ...

... relationships between the hypothalamic-pituitary-adrenal and catecholamine ... catecholamine release in hypothalamus and prefrontal cortex in freely ...

Although the catecholamine biosynthesis inhibitor alpha-methyltyrosine markedly lowers brain catecholamines, the rate of their depletion was not accelerated by (1) allowing male mice to fight or (2) aggregating strange females together. In view of the fac...

... Accession Number : ADA229126. Title : Uses of Tyrosine in Foods to Amplify Catecholamine Release. Descriptive Note : Final technical rept. ...

... Accession Number : ADA190530. Title : Use of Tyrosine or Foods to Amplify Catecholamine Release. Descriptive Note : Final rept. ...

... Accession Number : ADA160274. Title : Use of Tyrosine or Foods to Amplify Catecholamine Release. Descriptive Note : Interim technical rept. ...

... Accession Number : ADA290643. Title : Correlation of Real-Time Catecholamine Release and Cytosolic CA2+ at Single Bovine Chromaffin ...

The direct effect of alpha 2-autoreceptors was studied by measuring the effects of piperoxan, an alpha 2-autoreceptor antagonist and clonidine, an agonist on catecholamine exocytosis from single bovine chromaffin cells in culture. Catecholamine release wa...

Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments

Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments

... cells normally release hormones called catecholamines, such as epinephrine (adrenaline) and norepinephrine. Eventually the body breaks these down ...

... The importance of adrenaline as a supplementary hormone of defense against cold is shown by the lower ability of adrenalectomized corticoids ...

Catecholamines and propranolol were chemically bound to Sepharose and glass beads and washed extensively. The complexes were unstable and bound ligands were gradually released into the supernatants.

... G. and O. Homyliewicz. Catecholamines in regulation of motor function. In Catecholamines and Behavior (A. J. Friedhoff, Ed.), ... ...

This project examined the effects of supplemental tyrosine on catecholamine (CA) release and on various behaviors and brain functions thought to be mediated by CAs. It included studies on both human and experimental animals. The human studies focused on: ...

The rate of catecholamine release was examined at perfusion sites in the diencephalon of the unanesthetized rat during the perfusion of a solution of 6-hydroxydopamine (6-OHDA) or desipramine (DMI). Endogenous stores of norepinephrine (NE) and dopamine (D...

... Abstract : Exocytotic secretion of catecholamines from bovine adrenal medullary cells in culture was examined by amperometry with 1-micrometer ...

... detection. The initial studies have focussed on resolving threonine, glycine, and histidine peaks for a study of CSF samples. ...

... Two electrochemical techniques were employed: cyclic voltammetry and amperometry. Spikes obtained by amperometry ...

... of glucocorticoid hormones and plasma catecholamines, and release of the stress-responsive neurotransmitter, norepinephrine (NE), throughout ...

... Diphacil stabilizes the presynaptic reservoirs of catecholamines, nicotine releases noradrenalin and, apparently, dopamine from the presynaptic ...

... of the basic microscope setup and accompanying equipment for quantifying catecholamine release from individual cells by amperometry. ...

... There were no significant difference in either plasma norepinephrine or epinephrine concentration between arms. Plasma ...

It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can synthesize and release catecholamines which then can regulate T cell function. We have shown recently that macrophages and ...

... 7 X 10 to the -5th power M, caused as immediate, marked increase in oxygen consumption unaccompanied by any change in the rate of release of ...

Pheochromocytoma is an endocrine tumor that can uniquely mimic numerous stress-associated disorders, with variations in clinical manifestations resulting from different patterns of catecholamine secretion and actions of released catecholamines on physiological systems.

Previously, we reported that atrazine disrupts ovarian function by altering hypothalamic catecholamine (CA) concentrations and the consequent regulation of pituitary LH release and prolactin secretion in the young female rat. We also showed that atrazine directly interacts with t...

The effects of four major chlorotriazine metabolites on the constitutive synthesis of the catecholamines dopamine (DA) and norepinephrine (NE) were examined using undifferentiated PC12 cells. NE release and intracellular DA and NE concentrations were quantified following treatme...

Catecholamines given in high concentrations produce myocardial damage in several mammalian species. The histological changes are similar to those found in patients given large amounts of pressor agents and in those who develop pheochromocytomas. They include myofiber necrosis, myofibrillar degeneration, and mononuclear leukocytic infiltration. Cardiac function is significantly ...

... Maximum 200 words) Exocytotic secretion of catecholamines from bovine adrenal medullary Cells in culture was examined by amperometry with 1 ...

... Effect of Tyrosine on Maintenance of Blood Pressure Conlay, LA, Maher, TJ and Wurtman, RJ Spinal cord noradrenergic neurons are activated in ...

... blood pressure � Release of catecholamines (stress hormones, including epinephrine, which is also known as adrenaline) from the adrenal glands � Increased oxygen demand on ...

Authentic foods affect brain serotonin synthesis by modifying brain tryptophan levels, carbohydrates

The work carried out as part of a general research program included studies on peripheral localization of the adrenergic neurotransmitter, uptake, release and storage of catecholamines in the nerve, and adrenergic neurotransmission in vitro and in vivo. D...

The effects of chronic treatment with estrogen and catecholestrogens on the levels of norepinephrine, epinephrine, and dopamine in various organs of rats were studied. Results are highly significant in that estrogen affects the levels of the neurotransmit...

... NDIA - National Defense Industrial Association Conference Proceedings ... Upon rewarming, plasma norepinephrine peaked within two minutes in the ...

Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of mid...

Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indi...

The release of endogenous dopamine and norepinephrine from six brain regions (cortex, hippocampus, hypothalamus, striatum, s. nigra, n. accumbens-o.tubercle) of chronically lead-exposed rats was compared to release from controls. Prenatal and postnatal ch...

1. The perfused isolated cow adrenal gland was used to investigate the effect of barbituric acid, phenobarbitone and pentobarbitone on catecholamine secretion. 2. Pentobarbitone reduced catecholamine secretion induced by a number of drugs which cause exocytosis. The concentration of pentobarbitone which caused a 50% inhibition of ...

We present here the first reported case of mid-ventricular stress cardiomyopathy secondary to 'Irukandji syndrome', following envenomisation from a jellyfish. Carukia barnesi is a cubozoan or box jellyfish found in Far North Queensland, Australia prevalent during the warmer months of the year. It has been associated with 'Irukandji syndrome' as characterized by a sympathetic overdrive secondary to ...

Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environmental mixture of polychlorinated biphenyls (Aroclor 1254) on ...

Fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes has been used to demonstrate that sub-second changes in catecholamine concentration occur within the nucleus accumbens (NAc) shell during motivated behaviors, and these fluctuations have been attributed to rapid dopamine signaling. However, FSCV cannot distinguish between dopamine and norepinephrine, and ...

A wide variety of experimental animal models have been used to investigate the mechanisms of synthesis, storage, and release of catecholamines. Whereas in vivo experimental models are situated at one end of the spectrum, cell culture models are situated at the other end. In the present study, we have characterized various aspects of the rat adrenal medulla ...

This study evaluated alterations in catecholamines, blood flow, and indices of tissue damage during early myocardial ischemia in the dog. Of the 27 animals studied, the left anterior descending artery was ligated for 1 hour in 11 and for 3 hours in 13, and 3 underwent sham procedures. The severity of ischemia was determined by the radioactive microsphere and thioflavin S ...

An experimental system using rat caudate slices was used to measure the effects of tyrosine on neuronal activity. Studies demonstrated the importance of adequate tyrosine in sustaining dopamine release and provide the first evidence that when sufficient e...

The results demonstrate that decaborane acutely releases noradrenaline from the heart stores. It has been previously shown that tissues can be refilled with catecholamines after noradrenaline stores have been depleted by decaborane. This study clearly dem...

To investigate the possible involvement of the adrenal cortex and medulla in the cardiovascular effects of naloxone and thyrotropin-releasing hormone (THR) in endotoxic shock, plasma epinephrine, norepinephrine, dopamine and corticosterone were measured a...

Compared to preparations from control animals, superfused striatal slice preparations from brains of rats treated chronically with ethanol released a significantly greater fraction of stored (TH) dopamine on depolarisation in 40 mM K . Similarly, the electrically-evoked release of (TH)-norepinephrine from cortical slices and of (TH)-dopamine from striatal ...

Rett Syndrome (RTT) is a progressive developmental disorder resulting from loss of function mutations in the gene encoding MeCP2 (methyl-CpG-binding protein 2), a transcription regulatory protein. The RTT phenotype is complex and includes severe cardiorespiratory abnormalities, dysautonomia and behavioral symptoms of elevated stress. These findings have been attributed to an apparent hyperactivity ...

The relaxation of the frog myocardium is decelerated by addition of adrenaline (10(-8)-10(-6) M) into the perfusion solution. The catecholamines in low concentrations up to 5.10(-8) M decelerate the relaxation, and in higher concentrations accelerate the drop of mechanical tension in capillary muscles of the cat ventricular myocardium. The ...

The aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Accordingly, the constitutive and regulated release of both NPY and catecholamines was measured simultaneously in cultured ...

1. Milacemide (2-n-pentylaminoacetamide) is a glycine prodrug which readily crosses the blood brain barrier and increases brain glycine and glycineamide. In vitro and in vivo studies, with numerous tissues, including adrenal chromaffin cells, have clearly shown that the formation of the latter metabolites is exclusively mediated by monoamine oxidase B for which milacemide is a substrate. 2. ...

1. The effect of angiotensin-II-amide on the biosynthesis of catecholamines (CA) has been studied in a number of isolated tissues in vitro. 2. Angiotensin increased the synthesis of CA from ¹⁴C-tyrosine in guinea-pig atria and portal vein, in rat vasa deferentia and the rabbit portal vein. 3. Angiotensin had no effect on synthesis of CA from ...

Increased release of free fatty acids (FFA) from visceral fat cells to the portal venous system may cause several metabolic disturbances in obesity. However, this hypothesis and the underlying mechanism remain to be demonstrated. In this study catecholamine-induced lipid mobilization through lipolysis in omental adipose tissue was investigated in vitro in ...

Matrix type tablets containing 7-hydroxyethyltheophylline, L-noradrenaline and L-isoproterenol were coated with Eudragit RS 100 film containing different concentrations of 1,2-propyleneglycol (PG) and tributylcitrate (TBC) as hydrophylic and lipophilic softeners, respectively, to effect a controlled liberation of the substances. In-vitro and in-vivo tests show that PG increasingly ...

Secretion of catecholamines from single bovine chromaffin cells in culture was elicited by brief pressure ejections from a micropipette containing nicotine, carbamoylcholine, or potassium ions or by mechanical stimulation. Release was monitored electrochemically with a carbon-fiber microelectrode placed adjacent to the cell. Cyclic voltammetry was used to ...

Nicotine evokes the release of catecholamines from perfused cat adrenal glands in a concentration-dependent manner, the median effective concentration for nicotine being 5 microM. Two 2 min pulses of 5 microM-nicotine, 40 min apart (S1 and S2) gave net catecholamine outputs of 7.64 and 3.55 micrograms/8 min, respectively. The ratio ...

The role of the L-type calcium channel (Cav1.2) as a molecular switch that triggers secretion prior to Ca²⁺ transport has previously been demonstrated in bovine chromaffin cells and rat pancreatic beta cells. Here, we examined the effect of specific Cav1.2 allosteric modulators, BayK 8644 (BayK) and FPL64176 (FPL), on the kinetics of catecholamine ...

Disruption of performance observed when animals are exposed to physical stressors which deplete brain catecholamines can be alleviated by pretreatment with the catecholamine precursor tyrosine. Central administration of the stress hormone corticotropin re...

MUCH more is known about the molecular constitution of the storage mechanism for catecholamines than about how acetylcholine (ACh) is stored, although morphine and related drugs are known to inhibit its release. Because adenosine triphosphate (ATP) seems to be involved in the storage of catecholamines in the chromaffin granules of the ...

trout, Oncorhynchus mykiss Katherine A. Sloman,b Colin J. Montpetit,c and Kathleen M. Gilmoura: Social interactions; Stress; Cortisol; Catecholamines; Rainbow trout; Oncorhynchus mykiss; In situ (Oncorhynchus mykiss) of either sex (weight 252:2 � 8:0 g; length 27:4 � 0:2 cm; means� SEM; N � 40) were

acanthias) and the seawater-adapted rainbow trout (Oncorhynchus mykiss) were exposed to acute environmental or hypercapnia. Key words: Oncorhynchus mykiss, Squalus acanthias, catecholamines, ventilation, hypoxia) AND A TELEOST (ONCORHYNCHUS MYKISS) STEVE F. PERRY1,2,* AND KATHLEEN M. GILMOUR1,3 1Bamfield Marine Station

The effects of clonidine on adrenal catecholamine (adrenaline and noradrenaline) secretion were investigated in chloralose-anaesthetized dogs. Intravenous administration of clonidine (10 and 20 micrograms kg-1) induced a decrease in both adrenal catecholamine secretion rates and cardiovascular parameters (blood pressure and heart rate). In contrast, a dose ...

Neuroendocrine chromaffin cells of the adrenal medulla represent a primary output for the sympathetic nervous system. Chromaffin cells release catecholamine as well as vaso- and neuro-active peptide transmitters into the circulation through exocytic fusion of large dense-core secretory granules. Under basal sympathetic activity, chromaffin cells ...