Although acute renal failure is encountered with administration of nephrotoxic drugs, ischemia, or unilateral nephrectomy, there has been no effective drug which can be used in case of acute renal failure. Hepatocyte growth factor (HGF) is a potent hepatotropic factor for liver regeneration and is known to have mitogenic, motogenic, ...

Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target cell type. During the earlier stages of chronic renal failure, renal ...

Groups of young adult (C57LxA)F/sub 1/ mice were subjected to several different treatments: 690 rad whole-body x-irradiation; unilateral nephrectomy and no irradiation; 690 rad irradiation followed by unilateral nephrectomy 1 hour later; unilateral nephrectomy followed by 690 rad irradiation 3 hours later; unilateral nephrectomy, 690 rad 3 hours later. The mice were examined 1 year ...

... Therapeutic Administrati in of Recombinant Human Granulocyte Colony- Stimulating Factor Accelerates Hemopoietic Regeneration and Enhances ...

Trained unanesthetized dogs were exposed to positive centrifugal accelerations up to +6Gz. Renal arterial pressure and inferior vena cava pressure at kidney level were measured through indwelling catheters. Renal blood flow velocity was measured by a Dopp...

Trained unanesthetized dogs were exposed to negative centrifugal accelerations up to -3Gz. Renal arterial pressure and inferior vena cava pressure at kidney level were measured through indwelling catheters. Renal blood flow velocity was measured by a Dopp...

The course of reparative regeneration after 5/6 nephrectomy and use of low-dose radiation has been studied by means of light and electron microscopy. The experiments were performed on 30 male Wistar rats. All animal procedures were conducted after approval of the protocol by the animal Studies Ethics Committee of the University of Tartu. Renal ablation was ...

5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin induced acute renal failure (ARF) plus vehicle treatment; 3) ...

Intrinsic stem cells (SC) participate in tissue remodeling and regeneration in various diseases and following toxic insults. Failure of tissue regeneration is in part attributed to lack of SC protection from toxic stress of noxious stimuli, thus prompting intense research efforts to develop strategies for SC protection and functional preservation for in ...

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive deterioration of renal function and formation of cysts, and is an important cause of end-stage renal disease. Previously we showed that tubular epithelial injury accelerates cyst formation in inducible Pkd1-deletion mice. In these mice, expression of ...

... Title : Regenerative Flywheel Energy Storage System,. ... a portion of the vehicle's accelerating energy and regenerates the vehicle's braking energy. ...

Quantitative histological study revealed that regeneration of sectioned guinea pig facial nerve is accelerated by exposure to a moderate hypergravitic field of 1.6g. A two fold increase in rate of regeneration and in sprouting was observed. Scar tissue formation was significantly reduced in animals exposed to the hypergravitic field. ...

Percutaneous transluminal renal angioplasty with stenting has been effective in the control of hypertension, renal function, and pulmonary edema caused by atherosclerotic renal artery stenosis. However, the role of the procedure has not been fully established in the context of chronic total occlusion of renal ...

We studied autocrine transforming growth factor (TGF)? signaling in kidney epithelium. Cultured proximal tubule cells showed regulated signaling that was high during log-phase growth, low during contact-inhibited differentiation, and rapidly increased during regeneration of wounded epithelium. Autoregulation of signaling correlated with TGF? receptor and Smad7 levels, but not ...

The complicated geometry of the renal circulation system and the nature of the tissues that surrounds it are defined by an idealized circuit for use in pressure drop and heat transfer descriptions during renal perfusion. Numerical and analytical transient...

The renal medulla, the inner compartment of the metanephric kidney, plays vital roles in the regulation of body water, electrolyte homeostasis, and systemic blood pressure. It is composed of the loops-of-Henle, the medullary collecting ducts, the vasa recta, and the medullary interstitium. Its epithelial and endothelial components display ordered spatial organization. This ...

A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and systemic immune systems involved in ...

The effects of one hour of uninterrupted -7Gx acceleration on rate of urine flow and urinary excretion of sodium, potassium, and total solute were studied in rabbits. Urine flow rate during exposure to acceleration fell to an average of 56 per cent of con...

Results are reported from studies on the differences in changes in systolic arterial blood pressure following renal x-irradiation (1100 R) in adrenal-intact, adrenalectomized, and adrenal-regenerating rats and the roles of the kidneys and of the adrenal glands in the blood pressure changes. (auth)

Results are reported from studies on the differences in changes in systolic arterial blood pressure following renal x-irradiation (1100 R) in adrenal-intact, adrenalectomized, and adrenal-regenerating rats and the roles of the kidneys and of the adrenal g...

Emblica officinalis (Amla) accelerated cell proliferation and dedifferentiation of pigmented epithelial cells of dorsal iris and consequently induced lens regeneration in R. cyanophlyctis. Further it enhanced the percentage of lens regeneration not only in young tadpoles but also is adult frogs. Lens regeneration ...

Because an accelerated form of cardiovascular disease continues to limit the survival of both hemodialysis and renal transplant patients, investigative efforts in these patients have been directed toward the elucidation of the mechanism(s) of hyperlipidem...

Because an accelerated form of cardiovascular disease continues to limit the survival of both hemodialysis and renal transplant patients, attention has been directed to the cardiovascular risk factor, hyperlipidemia, which occurs frequently in these patie...

The mechanism of the hyperlipidemia of chronic renal failure involves either a defect in removal mechanisms or an accelerated synthesis. Analysis of the plasma lipoprotein spectrum of fasting uremic patients before scheduled dialysis has revealed some int...

... AC and Chung, LW (1995) c-met proto-oncogene expression Taichman, RS, Cooper, C., Keller, ET, Pienta, KJ ... cardiovascular and renal function. ...

The chemistry of lithium peroxide was studied for use as a nonregenerative air revitalization material for oxygen supply and carbon dioxide removal. The use of catalysts to accelerate the decomposition of the hydrogen peroxide formed as an intermediate in...

Recently published epidemiological and outcome analysis studies have brought to our attention the important role played by acute kidney injury (AKI) in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). AKI accelerates progression in patients with CKD; conversely, CKD predisposes patients to AKI. This research gives credence ...

Axon regeneration has long been studied in vertebrate model organisms and neuronal cultures. Recent development of axon regeneration paradigms in genetic model organisms, such as C. elegans, Drosophila and zebrafish, has opened an exciting field for in vivo functional dissection of regeneration pathways. Studies in these organisms have ...

Fetal exposure to high doses of glucocorticoids slows cellular development and impairs organ performance, in association with growth retardation. Nevertheless, low doses of glucocorticoids may enhance cell differentiation and accelerate specific functions...

The rationale, significance and pitfalls of currently available methods for the determination of glomerular filtration rates in children with advanced chronic renal diseases are reviewed. Normal renal clearances in infants and children from birth to adulthood are presented. Methods of serial measurements of renal function, especially ...

Renal cell carcinoma (RCC) is often detected incidentally and early. Currently, open partial nephrectomy and laparoscopic total nephrectomy form competing technologies. The former is invasive, but nephron-sparing; the other is considered less invasive but with more loss of renal mass. Traditionally, emphasis has been placed on oncologic outcomes. However, ...

Hyperlipidemia worsens diabetic nephropathy, although the mechanism by which renal lipids accumulate is unknown. We previously demonstrated that renal proteoglycans have high low-density lipoprotein (LDL) binding affinity, suggesting that proteoglycan-mediated LDL retention may contribute to renal lipid accumulation. The aim of this ...

1. The ligation of blood vessels of one kidney of adult rats resulted in the compensatory hypertrophy of the other kidney. In most animals the rate of hypertrophy was indistinguishable from that observed after unilateral nephrectomy, but in a few cases the onset was retarded when the renal artery alone had been ligated and the collateral circulation increased. 2. When the ...

Deterioration of renal function is typically slow but progressive, and therefore renal disease is often diagnosed in a late stage when already serious complaints occur. Ultimately when renal function has dropped below 10%, renal replacement is required. Renal transplantation provides a ...

A sorbent-based low volume recirculating peritoneal dialysate regeneration system developed by Organon Teknika Corp. has undergone initial clinical testing and currently has been successfully used by a single patient with end stage renal disease in the ho...

Adrenalectomized, adrenal-enucleated and adrenal-intact rats were sham-irradiated or received an x-ray dose of 1100 rad bilaterally to temporarily exteriorized kidneys. Systolic blood pressures were measured at 10, 25, 40, 60, and 80 days after irradiation. At 100 days after irradiation the rats were sacrificed for gross pathologic examination and renal histopathologic studies ...

One of the first hallmarks of kidney regeneration is the reactivation of genes normally required during organogenesis. Identification of chemicals with the potential to enhance this reactivation could therapeutically promote kidney regeneration. Here, we found that 4-(phenylthio)butanoic acid (PTBA) expanded the expression domains of molecular markers of ...

One of the first hallmarks of kidney regeneration is the reactivation of genes normally required during organogenesis. Identification of chemicals with the potential to enhance this reactivation could therapeutically promote kidney regeneration. Here, we found that 4-(phenylthio)butanoic acid (PTBA) expanded the expression domains of molecular markers of ...

By establishing the renal supleetion procedure, the patients with cronic renal failure also have an acceleration of arterial hypertension. The management of this situation calls for the understanding of the generating mechanisms (hipervolemia by the reduction of natriuresis and hiperreninemia) and the adaptation of the therapeutical ...

Significant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells for potential clinical applications of organ regeneration. Accordingly, kidney ...

It has been already established that a tendency towards synchronization and acceleration of the forelimb and lens regeneration is observed in Pleurodeles waltlii under the effect of space flight factors. Here we present the results obtained after 16-day space flight of two groups of newts. In animals of group I forelimbs were amputated and lenses were ...

The intracellular mechanisms underlying renal tubular epithelial cell proliferation and tubular repair following ischemia-reperfusion injury (IRI) remain poorly understood. In this report, we demonstrate that activator of G-protein signaling 3 (AGS3), an unconventional receptor-independent regulator of heterotrimeric G-protein function, influences renal ...

Serum amyloid A protein (SAA), a prominent component of the acute-phase response, is strongly expressed in developing and repairing kidneys and promotes tubulogenesis. Accordingly, we reprogrammed relatively undifferentiated NRK52E cells with the mouse SAA1.1 gene and transplanted SAA-positive and -negative cells into rats with acute renal failure. We found that SAA-positive ...

of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and John Mc. of Medicine, Division of Nephrology, Univ. of Arkansas for Medical Sciences 4301 West Markham, Slot 501�149, 1997. 30. Toback FG. Control of renal regeneration after acute tubular necrosis. In: Nephrology, edited

Anion exchange resins sorbed with perchlorate may be regenerated by a combination of chemical reduction of perchlorate to chloride using a reducing agent and an electrochemical reduction of the oxidized reducing agent. Transitional metals including Ti, Re, and V are preferred chemical reagents for the reduction of perchlorate to chloride. Complexing agents such as oxalate are ...

The effect of low-intensity millimeter wave electromagnetic radiation (MWR) on regeneration of the rat sciatic nerve after transection and microsurgical reapproximation was examined. Rates were exposed to 54 GHz MWR at a power density of 4 mW/cm{sup 2}. It was found that MWR treatment of the femoral skin in the area of suture accelerated the ...

One of the grand challenges in neuroengineering is to stimulate regeneration after central nervous system (CNS) or peripheral nervous system (PNS) injury to restore function. The state of the art today is that PNS injuries heal to a limited extent, whereas CNS injuries are largely intractable to regeneration. In this context, we examine the underlying ...

Methylmercury has been found to retard fin regeneration in the marsh killifish, Fundulus confluentus, and striped mullet, Mugil cephalus. Cadmium, which also retarded fin regeneration in killifhsh interacted antagonistically with methylmercury so that fish exposed simultaneously to the two metals exhibited growth rates comparable to controls. Current ...

End stage renal disease is a major health problem in this country and worldwide. Although dialysis and kidney transplantation are currently used to treat this condition, kidney regeneration resulting in complete healing would be a desirable alternative. In this review we focus our attention on current therapeutic approaches used clinically to delay the ...

For better understanding of micro-"g" effect on nervous tissue regeneration we have chosen the regeneration of the Urodele tail, because it utilizes many developmental processes and represents the most convenient model for experiments in Space. The special interesting aspect lies in the ability of regenerates to differentiate the ...

Urinary acidification is a complex process requiring the coordinated action of enzymes and transport proteins and resulting in the removal of acid and the regeneration of bicarbonate. Proton secretion is mediated by luminal H(+)-ATPases and requires the parallel movement of NH?, and its protonation to NH?(+), to provide sufficient buffering. It has been long assumed that ...

Appendage regeneration is defined by rapid changes in gene expression that achieve dramatic developmental effects, suggesting involvement of microRNAs (miRNAs). Here, we find dynamic regulation of many miRNAs during zebrafish fin regeneration. In particular, miR-133 levels are high in uninjured fins but low during regeneration. When ...

BACKGROUND: Rats that recovered from mild proximal tubule (PT) injury without renal dysfunction by subtoxic insult, developed partial resistance to subsequent nephrotoxic insult. This partial resistance was associated with reduced renal dysfunction and accelerated PT cell proliferation compared with vehicle treatment as the first ...

Comparative analysis of experimental studies on regeneration of bone and muscle tissue under the influence of space flight factors (SFF) during restoration of experimental fracture in rats and epimorphic limb regeneration in adult newt is presented SFF-induced retardation of regeneration in mammals and its ...

The most important data obtained in studies of the influence of space flight factors on the limb and lens regeneration in the newt Pleurodeles waltlii have been summarized. Regeneration of these organs under the conditions of space flight and after its termination proceeded just as on the ground. However after the 7th, 13th and 16th days of space flight, a ...

Rats receiving a single oral dose of 286.8 mumol/kg tris(2,3-dibromopropyl)phosphate (Tris-BP) showed pyknosis of the renal tubular epithelial cells on Day 1, necrosis on Day 2, regeneration from Day 3 and large nuclei formation from Day 4. 13C-NMR spectra were applied to clarify changes of the renal low-molecular-weight components in ...

Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ppm or higher concentrations induced renal tubule carcinomas ...

Fissile fuel production by linear accelerators has advantages over fast breeders with respect to the absence of critically problems and a higher net production rate of fuel. As part of the NASAP effort, a design study of the light-water reactor fuel enricher/regenerator, has been performed under the restriction that fuel was not to be reprocessed. The ...

Fissile fuel production by linear accelerators has advantages over fast breeders with respect to the absence of criticality problems and a higher net production rate of fuel. As part of the NASAP effort, a design study of the light-water reactor fuel enricher/regenerator, has been performed under the restriction that fuel was not to be reprocessed. The ...

SUMMARYAccumulation of toxic metabolites in tyrosinemia type I (HT1) patients leads to chronic DNA damage and the highest risk for hepatocellular carcinomas (HCCs) of any human disease. Here we show that hepatocytes of HT1 mice exhibit a profound cell cycle arrest which, despite concomitant apoptosis resistance, causes mortality from impaired liver regeneration. However, ...

Adrenalectomized rats and rats containing regenerating enucleated adrenals or homotransplanted ad renals were irradiated with 600 r of x rays. The volumes of regenerated adrenal cortical tissue were measured at various times after enucleation and these volumes were correlated with the 30-day lethality of adrenal enucleated ...

The incidence and the rate of progression of nondiabetic renal disease is generally greater in men compared with age-matched women, suggesting that the female sex is protective and/or that the male sex is a risk factor for the development and progression of nondiabetic renal disease. In diabetes, even though the male sex still appears to be a risk factor, ...

The roles of intrarenal angiotensin (A) and thromboxane (TX) in the vascular hypersensitivity to renal nerve stimulation (RNS) and paradoxical vasoconstriction to renal perfusion pressure (RPP) reduction in the autoregulatory range in 1 wk norepinephrine (NE)-induced acute renal failure (ARF) in rats were investigated. ...

Animals recovered from acute renal failure are resistant to subsequent insult. We investigated whether rats recovered from mild proximal tubule (PT) injury without renal dysfunction (subclinical renal damage) acquire the same resistance. Rats 14 days after recovering from subclinical renal damage, which was induced ...

Animals recovered from acute renal failure are resistant to subsequent insult. We investigated whether rats recovered from mild proximal tubule (PT) injury without renal dysfunction (subclinical renal damage) acquire the same resistance. Rats 14 days after recovering from subclinical renal damage, which was induced ...

Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. ...

Hypertensive crises are situations when arterial hypertension shows its immediate damaging potential, and in such circumstance, antihypertensive therapy provides its life-saving effectiveness. Among these situations are hypertensive emergencies, hypertensive urgencies, hypertensive encephalopathy, and also accelerated-malignant hypertension characterised by the presence of ...

MET. Time of Day (EST). Deorbit Burn 9/03:29 7:04 AM, Mar. 30 ..... The LSLE will be operated in the freezer mode at -22 degrees C on orbit and ... These samples will be analyzed on Earth for evidence of accelerated renal ...

A spontaneous form of progressive intercapillary glomerulosclerosis (IGS) develops in RF/Un mice in early life and is accelerated by neonatal irradiation. The lesions are similar to those seen in mice with viral infections and may be of viral origin. Dail...

... growth and angiogenesis by vitamin D3 agents in murine renal cell carcinoma. ... factor/scatter factor (HGF/SF) and its receptor, c-met protooncogene, ...

... 0.2% FCS, respectively, were used. To determine growth stimulation ratios, the optical density of BrdU-incorporated cells ... of Steroid Hormones in In Vitro Assessment of Growth Stimulation in IEC-6 Cell...

ABS>A procedure for obtaining renograms is presented with acceleration of the vascular phase and determination of bladder and blood radioactivity at thirty minutes. A technic of analysis is proposed, disassociating the vascular phase and the secretory-excretory phase. This method is compared to others commonly employed. Parameters expressing the rates of ...

A window assembly is designed which is based on the auto-regeneration property, i.e., the recovery of the optical characteristics of the glass. The window assembly comprises two identical glass slabs assembled in edge-to-edge relation, a screen located adjacent to the aperture in the wall, and means for reciprocating the glass slab assembly so that the slab which was ...

Dye-sensitized photosynthesis: Eosin Y (EY), a dye photosensitizer, works efficiently as a molecular photoelectrode by catalyzing the visible-light-driven electron-transfer reaction for efficient regeneration of NADH through a photosensitizer-electron relay dyad. Injection of the photosensitized electron resulted in highly accelerated ...

2,4-Diaminophenol dihydrochloride is used in the manufacture of dyes and as a color accelerator in photographic developers. Toxicology and carcinogenesis studies were conducted by administering 2,4-diaminophenol dihydrochloride (greater than 97% pure) in corn oil by gavage to F344/N rats and B6C3F1 mice for 16 days, 13 weeks, and 2 years. Genetic toxicology studies were ...

Following recent advancements of stem cell research, the potential for organ regeneration using somatic stem cells as an ultimate therapy for organ failure has increased. However, anatomically complicated organs such as the kidney and liver have proven more refractory to stem cell-based regenerative techniques. At present, kidney regeneration is considered ...

These studies support development work in atmospheric and pressurized fluidized-bed coal combustion. The problems to be addressed in designing a regenerator larger than a PDU unit are discussed. Work has begun on the evaluation of rotary kilns (presently ...

Transformation and regeneration phenomena are calculated to result from transmission through the Earth of neutrinos with E(MeV)/..delta..m/sup 2/(eV)/sup 2/ in the vicinity of 10/sup 6/ to 10/sup 7/. As a result, large time-of-night and seasonal variations are predicted for various solar neutrino experiments in this parameter range. Analagous effects are predicted for ...

The report studies twelve-year postharvest diameter growth of advance Douglas-fir, Engelmann spruce, and subalpine fir regeneration and 11-year height growth of Douglas-fir and subalpine fir accelerated in response to decreasing competition. Competition w...

BackgroundRenal ischemia leads to apoptosis of tubular epithelial cells and results in decreased renal function. Tissue repair involves re-epithelialization of the tubular basement membrane. Survival of the tubular epithelium following ischemia is therefore important in the successful regeneration of renal tissue. ...