We examined cell killing and chromatid damage in primary human bronchial epithelial cells irradiated

Mar 1, 2011 ... Complex Chromosomal Rearrangements Induced in Vivo by Heavy Ions ... human peripheral blood lymphocytes after in vitro exposure to gamma rays or accelerated (56)Fe ions (1 ..... Thesis (15) [x]. show hide NASA Center ...

... added either during or after irradiation in either cell line. MATERIALS AND METHODS Cells LY cells were derived from a thymic tumor ... ...

The oncogenic potential of high-energy 56Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T12 cell model. The dose-averaged LET for high-energy 56Fe is estimated ...

... 1 GeV/nucleon, 500 and 200 MeV/nucleon iron-ion beams; only for the 5 GeV/nucleon beam it is significantly higher (1.71 ± 0.19), but it is still less than ... ...

... ions (29), 2.4 for 110 keV/μm argon ions (30), 2.5�3.0 for 145�162 keV/μm carbon ions and 150�l55 keV/μm neon ions (31), 3.31 for 105.8 keV/μm α particles (32), 3.19 for 131 keV/μm neon ions ( ... ...

We measured fluence and fragmentation of high-energy (1 or 5 A GeV) 56Fe ions accelerated at the Alternating Gradient Synchrotron or at the NASA Space Radiation Laboratory (Brookhaven National Laboratory, NY, USA) using solid-state CR-39 nuclear track detectors. Different targets (polyethylene, PMMA, C, Al, Pb) ...

We measured fluence and fragmentation of high-energy (1 or 5 A GeV) 56Fe ions accelerated at the Alternating Gradient Synchrotron or at the NASA Space Radiation Laboratory (Brookhaven National Laboratory, NY, USA) using solid-state CR-39 nuclear track detectors. Different targets (polyethylene, PMMA, C, Al, Pb) ...

We measured the fluence of 1 A GeV 56Fe ions accelerated at the National Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory using plastic CR-39 nuclear track detectors. Different targets (polyethylene, PMMA, C, Al, Pb,) were used to produce a large spectrum of charged fragments. CR-39 plastics were ...

This report contains papers on the following topics: charge distributions in sup 56 Fe-induced reactions at 14.6 MeV/nucleon; quasi-elastic structure in the reaction sup 56 Fe + sup 56 Fe at 14.6 MeV/nucleon; and effects of particle evaporation in the N-Z...

This report contains papers on the following topics: charge distributions in /sup 56/Fe-induced reactions at 14.6 MeV/nucleon; quasi-elastic structure in the reaction /sup 56/Fe + /sup 56/Fe at 14.6 MeV/nucleon; and effects of particle evaporation in the N-Z plane.

/sup 48/Ca and /sup 56/Fe beams from the Super HILAC accelerator were used to irradiate thick metal foils of cerium and terbium. Product gamma ray activities were detected offline and individual products were identified by half-life, gamma ray energy and gamma ray abundances. The production cross sections were iteratively fit to charge ...

The lenses of mice exposed to 600 MeV/amu iron ions were evaluated by slit-lamp biomicroscopy and cytopathological analyses. The doses ranged from 0.05 to 1.6 Gy, and the lenses were assessed at several intervals postirradiation. Cataract, the development of which is dependent on both time and dose, is significantly more advanced in all of the exposed mice when compared to the ...

The lenses of mice exposed to 600 MeV/amu iron ions were evaluated by slit-lamp biomicroscopy and cytopathological analyses. The doses ranged from 0.05 to 1.6 Gy, and the lenses were assessed at several intervals postirradiation. Cataract, the development of which is dependent on both time and dose, is significantly more advanced in all of the exposed mice when compared to the ...

Yields have been measured with discrete Z and A resolution for Fe-like fragments produced in damped collisions between 8.3 MeV/amu /sup 56/Fe ions and /sup 56/Fe, /sup 165/Ho, and /sup 209/Bi targets. Both the fragment A/Z ratio and the relationship between the variances of the mass and charge ...

The neutron capture cross section of exp 56 Fe and exp 58 Fe has been measured in the energy range from 10 to 250 keV relative to the gold standard. A pulsed 3 MV Van de Graaff accelerator and the exp 7 Li(p, n) reaction served as a neutron source. Captur...

The activities of the nuclear chemistry program at Indiana University during the period September 1, 1982 to August 31, 1983 are reviewed. As in the past, these investigations have focused on understanding the properties of nucleus-nucleus collisions at low-to-intermediate energies. During the past year new programs have been initiated at the National Superconducting Cyclotron Laboratory at ...

Radiation risk management for human space missions depends on accurate modeling of high-energy heavy ion transport in matter. The process of nuclear fragmentation can play a key role in reducing both the physical dose and the biological effectiveness of the radiation encountered in deep space. Hydrogenous materials and light elements are expected to be more effective shields ...

... Descriptors : *Linear accelerators, *Ion accelerators, *Particle accelerator components, *Electron accelerators, *Proton accelerators, Electron beams ...

... (Author). Descriptors : *ION ACCELERATORS, ELECTROMAGNETS, ION BEAMS, FOCUSING, RINGS, USSR, LINEAR ACCELERATORS. ...

HZE particles from space radiation raise an important protection concern during long-term astronauts travels Although these particles are less abundant than protons they are more effective in damaging biological systems It is thought that this is due to the frequent production of spatially correlated DNA damaged sites particularly double strand breaks DSB since this correlation can strongly affect ...

Radiation risk management for human space missions dependson accurate modeling of high-energy heavy ion transport in matter. Theprocess of nuclear fragmentation can play a key role in reducing both thephysical dose and the biological effectiveness of the radiationencountered in deep space. Hydrogenous materials and light elements areexpected to be more effective shields ...

Purpose: Stem cells hold great potential for regenerative medicine, but they have also been implicated in cancer and aging. How different kinds of ionizing radiation affect stem cell biology remains unexplored. This study was designed to compare the biological effects of X-rays and of high-linear energy transfer (LET) {sup 56}Fe ions ...

The Scintillating Optical Fiber Isotope Experiment (SOFIE) is a balloon-borne experiment designed to measure the isotopic abundances of Si through Fe in the galactic cosmic rays (GCR) with energies between 460 and 1200 MeV/nucleon. The SOFIE incorporates there organic scintillation detectors, a fused silica Cherenkov detector, a scintillating optical fiber range detector, and a novel scintillating ...

We have investigated the damage morphology and magnetic properties of titanium dioxide thin films following implantation with Fe ions. The titanium dioxide films, having a polycrystalline anatase structure, were implanted with 100 keV 56Fe+ ions to a total fluence of 1.3 � 1016 ions/cm2. The ...

Lenses of mice irradiated with 250 MeV protons, 670 MeV/amu 20Ne, 600 MeV/amu 56Fe, 350 MeV/amu 56Fe, 600 MeV/amu 93Nb or 593 MeV/amu 139La ions were evaluated by analysing cytopathological indicators which have been implicated in the cataractogenic process. The LETs ranged from 0.39 to 953 ...

Liulin, a dosimetry-radiometry system, was developed to satisfy the requirements for active flux and dose rate measurements for the flight of the second Bulgarian cosmonaut in 1988. The system consists of a compact battery-operated silicon solid state detector unit and a read/write microcomputer and telemetry unit. We describe the pre-flight calibrations with charged particles, using radioactive ...

The neutron capture widths of s-wave resonances in exp 56 Fe (27.7 keV), exp 58 Ni(15.4 keV) and exp 60 Ni (12.5 keV) have been determined using a setup completely different from previous experiments. A pulsed 3-MV Van de Graaff accelerator and a kinemati...

Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to cosmic radiation might pose a similar risk for astronauts has increased. To address this question, we examined the effect of 2 to 5 Gy iron ions ((56)Fe), a particularly damaging ...

... warfare, joint planning, national and international ... a space charge wave accelerator. ... BEAMS, *ION ACCELERATORS, *PLASMA ACCELERATORS ...

Nuclear level densities and radiative strength functions (RSF) in {sup 56}Fe and {sup 57}Fe were measured using the {sup 57}Fe({sup 3}He,{alpha}{gamma}) and {sup 57}Fe({sup 3}He, {sup 3}He{prime}{gamma}) reactions, respectively, at Oslo Cyclotron Laboratory. A low-energy enhancement in the RSF below 4 MeV energy was observed. This finding cannot be ...

The capability of the CR-39 track detector for isotope identification was verified using 56Fe and 55Fe beams from the heavy ion accelerator HIMAC at NIRS. A CR-39 stack was exposed to 56Fe and 55Fe beams with the energies of 460 MeV/nucleon. Drastic improvements in the accuracies of microscopic image analysis and ...

The eyes of rats were exposed to doses of 0.1 and 2.5 Gy of 450-MeV/amu 56Fe particles (LET approximately 195 keV/microns). The beam axes were oriented perpendicular to the central retina of the animals. Retinas were harvested immediately (less than 10 min), 24 h, 15 days, 136 days, and 186 days after the experiment. The retinas of animals of equivalent ...

Astronauts are exposed to both musculoskeletal disuse and heavy ion radiation in space. Disuse alters the magnitude and direction of forces placed upon the skeleton causing bone remodeling, while energy deposited by ionizing radiation causes free radical formation and can lead to DNA strand breaks and oxidative damage to tissues. Radiation and disuse each result in a net loss ...

The overall objective is to study the mechanisms and the energy dependence of heavy ion fragmentation by studying the reactions of heavy ion projectiles (e.g. (sup 4)He, (sup 16)O, (sup 20)Ne, (sup 28)Si, (sup 56)Fe) in a variety of targets (H, He, C, Si,...

... Accelerator. A New Experiment in the Physics of Elementary Particles,. Corporate ... Subject Categories : PARTICLE ACCELERATORS. ...

... Descriptors : *ION ACCELERATORS, *LINEAR ACCELERATORS, SYMPOSIA, SEMICONDUCTOR DEVICES, PULSE GENERATORS, SOLID ...

... Descriptors : *PARTICLE ACCELERATORS, CYCLOTRONS, IONS, LINEAR ACCELERATORS, MAGNETIC PROPERTIES, MATRICES ...

Heavy ions of different nuclear structure have been elastically scattered from the even isotopes of tin. The projectiles used are the closed shell nucleus $sup 40$Ca and the neutron rich isobar $sup 40$Ar; the deformed nucleus $sup 20$Ne; and the higher z, fp-shell nuclei $sup 56$Fe and $sup 63$Cu. (auth)

... ACCELERATORS, *ION ACCELERATORS, RINGS, VACUUM APPARATUS, ELECTRONS, MAGNETIC FIELDS, CROSSED FIELD DEVICES ...

... warfare, joint planning, national and international ... tube ion accelerator as neutron ... TUBES, ION ACCELERATORS, MAINTENANCE EQUIPMENT ...

Three-grid ion accelerator in which accelerator grid is biased at negative potential and decelerator

... Descriptors : *ION ACCELERATORS, *LINEAR ACCELERATORS, ELECTRIC FIELDS, CATHODES, ELECTRON BEAMS, INSTABILITY, SPACE ...

Exposure to radiation from a variety of sources is associated with increased risk of heart disease and stroke. For example, for women with early breast cancer, the benefit of radiotherapy can be nearly offset by the increased risk of mortality from cardiovascular disease. Head and neck cancer patients who undergo radiation treatment are at significantly elevated risk of stroke, even in a ...

The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berkeley Laboratory BEVALAC. Expression of the tumorigenic potential of the initiated ...

... SCATTERING, *PARTICLE COLLISIONS, *ION ACCELERATORS, *ION ION INTERACTIONS, VELOCITY, ION DENSITY, LOSSES, NUCLEAR ...

... SEE), Latchup, Cyclotron, Accelerator, Lawrence ... ION ACCELERATORS, *CYCLOTRONS, TEST AND EVALUATION, FREQUENCY, IONS ...

... possibility that at high current densities an ... ACCELERATORS), SPACE CHARGE, MAGNETIC FIELDS ... EMISSION, TUNGSTEN, IONS, ION BEAMS ...

accelerate electrons? Parameter dependence of electron acceleration at shocks ? ... al., 2005). Many studies on ions, but how about electron acceleration ? ...

Several experiments were conduced aimed at studying the influence of shielding on biological effectiveness of high-energy ions Chromosome damage was assessed in human peripheral blood lymphocytes after in vitro exposure to the either 28 Si 490 or 600 MeV n 48 Ti 1000 MeV n or 56 Fe 600 1000 or 5000 MeV n LET values for these ...

Previous studies have shown that the eyes of ATM heterozygous mice exposed to low-LET radiation (X-rays) are significantly more susceptible to the development of cataracts than are those of wildtype mice. The findings, as well as others, run counter to the assumption underpinning current radiation safety guidelines, that individuals are all equally sensitive to the biological effects of radiation. ...

Ionizing radiation has been implicated in the development of significant cardiovascular complications. Since radiation exposure is associated with space exploration, astronauts are potentially at increased risk of accelerated cardiovascular disease. This study investigated the effect of high atomic number, high-energy (HZE) iron-ion radiation on vascular ...

We measured the induction of aberrations in human chromosome 5 by iron ions using the novel technique of multicolor banding in situ hybridization (mBAND). Human lymphocytes isolated from whole blood were exposed in vitro to 500 MeV/n (LET=200 keV/? m, doses 1 or 4 Gy) 56Fe nuclei at the HIMAC accelerator in Chiba ...

In order to clarify a rather confused issue the neutron capture cross section of exp 56 Fe between 16 and 60 keV was remeasured relative to gold under very clean conditions at the Karlsruhe Van de Graaff accelerator. The metallic samples were isotopically...

The NASA SPACE RADIATION LABORATORY (NSRL) has been constructed and started operations at the Brookhaven National Laboratory in 2003. The NSRL facility will be used by NASA to perform radiation effect studies on materials and biological samples for the space program. The facility utilizes proton and heavy-ion beams of energies from 50 to 3000 MeVln which are ...

... Descriptors : (*ION BEAMS, SCATTERING), IONS, ARGON, ENERGY, DISTRIBUTION, PARTICLE ACCELERATOR TARGETS, COPPER, ...

The observation of new neutron-rich isotopes of 52-53Sc, 54-55Ti, 56V, and 58-59Cr produced in damped collisions of 8.3 MeV/u 56Fe ions with 238U and 209Bi is reported. Tentative identification for 56Ti, 57-58V, 60Cr, 61Mn, and 63Fe is also presented. NUCLEAR REACTIONS 238U(56Fe, HI), E=8.3 ...

60Fe-60Ni systematics in quenched angrites and two old eucrites were investigated by secondary ion mass spectrometry. The 60Ni/62Ni isotopic compositions were normal within 2? errors. The inferred initial 60Fe/56Fe ratios for quenched angrites was (6�9)�10-9, and similar upper limit values were also obtained from eucrites. Using ...

We present Fe isotope compositions for magnetite crystals from >3.7 Ga banded iron formation (BIF) from the Isua Greenstone Belt and younger, spatially related pyrite obtained in situ by secondary ion mass spectrometry (SIMS). Across a distance of several millimeters, individual magnetite crystals of BIF show ?56Fe values up to ...

The heavy-ion collisions of (sup 56)Fe + (sup 232)Th, (sup 86)Kr + (sup 232)Th and (sup 136Xe) + (sup 232)Th with beam energies 15--20% above the Coulomb barrier were used to populate nuclei in the light-actinide region. Yield distributions of the binary ...

Recoil techniques have been used for a systematic study of deeply inelastic transfer reactions induced in rare earth targets by exp 40 Ar, exp 52 Cr, exp 56 Fe and exp 63 Cu projectiles. The targets were separated isotopes of Eu, Sm, Nd and Pr. The residu...

The range and energy loss rate for the ions 1H, 4He, 12C, 16O, 20Ne, 28Si, 40Ar, 56Fe, and 84K are given in the energy/nucleon interval 0.1 - 1200 MeV/amu. These quantities are tabulated for the stopping materials cellulose nitrate, cellulose acetate buty...