Radiation Therapy for Breast Cancer Quick Links Facts About Breast Cancer Treating Breast Cancer External Beam Radiation Therapy Accelerated Partial Breast Irradiation Radiation After Mastectomy Possible ...
MedlinePLUS
Early breast cancer incidence increases owing to mammography screening. Hypofractionated radiotherapy is more and more proposed in women with low local relapse risk breast cancer, especially accelerated partial breast irradiation. Various irradiation modalities have been reported: ...
PubMed
Modern breast cancer radiotherapy aims to increase uncomplicated cure rates. A priority is reduction of late effects which include chronic chest wall or breast pain, poor cosmesis, and cardiac toxicity. As breast screening detects early cancers we may be able to safely restrict irradiation postlumpectomy to the tumour bed with a ...
PubMed Central
Seven randomised trials are currently testing accelerated partial breast irradiation against whole breast radiotherapy after breast conservation surgery. The trials are varied in the techniques used to deliver partial breast radiotherapy, reflecting the ...
Before the era of breast-conserving therapy, brachytherapy implants were used to treat large inoperable breast tumors. In later years, interstitial brachytherapy with rigid needles or multiple flexible catheters has been used to deliver an additional (boost) dose to the tumor bed after breast-conserving surgery and ...
? Breast conservation is a safe and effective alternative to mastectomy for the majority of women with early-stage breast cancer. Adjuvant radiation therapy lowers the risk of recurrence within the breast and also confers a survival benefit. Although acute side effects of radiation therapy are generally well tolerated; efforts are ...
Accelerated partial breast irradiation has emerged as an important treatment option for select patients with early-stage breast cancer. Numerous techniques for the delivery of accelerated partial breast irradiation have been developed involving both ...
Objective:To critically review the theoretical and actual risks and benefits of accelerated partial breast irradiation (APBI) after breast-conserving surgery.Summary Background Data:Because of rapid evolution of radiation therapy techniques related to brachytherapy and three-dimensional conformal radiation therapy, ...
Lumpectomy; Wide local excision; Breast conservation surgery; Breast sparing surgery; Partial mastectomy
NCI/ASTRO Cancer Disparity Symposium and Reception Dr. Harold Freeman�s Presentation on Patient Navigation Attendees Attendees Dr. Frank Vicini�s Presentation on Accelerated Partial Breast Irradiation
Cancer.gov
Morphea is a localized form of scleroderma usually unaccompanied by the typical systemic stigmata that characterize progressive systemic scleroderma. It rarely manifests at the site of whole breast external-beam radiation therapy. We present an unusual case of radiation-induced morphea (RIM) that occurred after accelerated partial ...
Purpose: To examine the feasibility and acute toxicities of an accelerated, partial breast, intensity-modulated radiotherapy (IMRT) protocol. Methods and Materials: Between February 2004 and August 2005, 55 patients with Stage I breast cancer and initial follow-up were enrolled at four facilities on a HealthONE and ...
Energy Citations Database
A new method for treating early stage breast cancer, called accelerated partial breast irradiation (APBI), is described. This method is mostly being accomplished through the use of brachytherapy, whether it be interstitial or using the Mammosite(c) devise. APBI has proven to be effective but costly in a fiscal and ...
NASA Astrophysics Data System (ADS)
Purpose: To assess the incidence and severity of late normal tissue toxicity using three-dimensional conformal radiotherapy to deliver accelerated partial breast irradiation. Methods and Materials: A total of 60 patients were treated with three-dimensional conformal radiotherapy for accelerated ...
Purpose: To compare the dosimetry of proton and photon-electron three-dimensional, conformal, external beam accelerated partial breast irradiation (3D-CPBI). Methods and Materials: Twenty-four patients with fully excised, Stage I breast cancer treated with adjuvant proton 3D-CPBI had treatment plans generated using ...
Breast conservation therapy (BCT) is the procedure of choice for the management of the early stage breast cancer. However, its utilization has not been maximized because of logistics issues associated with the protracted treatment involved with the radiation treatment. Accelerated Partial ...
Purpose: To report the results of a detailed analysis of treatment failures after MammoSite breast brachytherapy for partial breast irradiation from our single-institution experience. Methods and Materials: Between October 14, 2002 and October 23, 2006, 78 patients with early-stage breast cancer were treated with ...
... cancer are removed. This is also called breast conservation therapy or partial mastectomy. Part of your breast ...
... with stage I or II breast cancer, breast-conservation therapy (lumpectomy/partial mastectomy plus radiation therapy) works ...
Purpose: Previous studies have shown that lumpectomy cavity volumes can change significantly in the weeks following surgery. The effect of this volume change on the surrounding tissue that constitutes the clinical target volume (CTV) for accelerated partial breast irradiation and boost treatment after whole breast ...
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation by means of multicatheter brachytherapy shows great promise in the modern treatment of early breast cancer combining high efficacy in preventing tumour recurrence with low levels of toxicity. The present work attempts a dosimetric comparison between ...
Purpose: To correlate the treatment planning parameters with the clinical outcomes in patients treated with accelerated partial breast intensity-modulated radiotherapy. Methods and Materials: A total of 105 patients with Stage I breast cancer were treated between February 2004 and March 2007 in a Phase II ...
Purpose: To evaluate with a randomized clinical trial the possibility of treating the index quadrant with external intensity-modulated radiotherapy (IMRT) in a selected group of patients with early-stage breast cancer and to analyze the acute toxicity. Methods and Materials: From September 2005, a randomized Phase III clinical trial has been conducted to compare conventional ...
Various subgroups of breast tumours have been identified during the last 10 years according to the risk of local relapse. Prognostic factors for local relapse are age, surgical margins, tumour size, Her2 expression and hormonal receptors status. For tumours with a high risk of local relapse, an increased in boost dose or the addition of new drugs (trastuzumab, antiangiogenics, ...
Inflammatory Breast Cancer; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Mucinous Ductal Breast Carcinoma; Papillary Ductal Breast Carcinoma; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB ...
ClinicalTrials.gov
Balloon-based brachytherapy was developed to simplify the brachytherapy technique and make accelerated partial breast irradiation more accessible to patients with breast cancer who are suitable candidates for this technique. Xoft Axxent (Xoft, Inc., Sunnyvale, CA) electronic brachytherapy is a novel method of ...
Purpose: To compare localization of the lumpectomy cavity by using breast surface matching vs. clips for image-guided external beam accelerated partial breast irradiation. Methods and Materials: Twenty-seven patients with breast cancer with two computed tomography (CT) scans each had three CT ...
, Accelerated Partial Breast Irradiation, Stereotactic Radiosurgery with Robotics, TomoTherapy and Stereoscopic-02 Slice Based Image Guidance with Tomotherapy K Sheng*1 , R Shaw2 , R Jeraj2 , T Mackie2 , B Paliwal2 , (1 CT images from treatment beams of tomotherapy. In slice based image guidance (SBIG), the patient
E-print Network
Purpose: To design and evaluate a magnetic resonance imaging (MRI) protocol to be incorporated in the simulation process for external beam accelerated partial breast irradiation. Methods and Materials: An imaging protocol was developed based on an existing breast MRI technique with the patient in the prone position ...
Purpose: To present guidance for patients and physicians regarding the use of accelerated partial-breast irradiation (APBI), based on current published evidence complemented by expert opinion. Methods and Materials: A systematic search of the National Library of Medicine's PubMed database yielded 645 candidate original research articles ...
The purpose of this study was to evaluate the dose to normal tissues as a function of increasing margins around the lumpectomy cavity in accelerated partial breast irradiation (APBI) using 3D-conformal radiotherapy (3DCRT). Eight patients with Stage 0-I breast cancer underwent treatment planning for 3DCRT APBI. The ...
Intraoperative radiotherapy (IORT) was originally introduced in breast cancer treatment as an "anticipated boost" during the procedure of breast conserving surgery (BCS). In addition to whole breast irradiation (WBI), it has yielded excellent long-term results [31, 38]. Under the assumption that the majority of ...
Purpose: To investigate the use of topotherapy for accelerated partial breast irradiation through field-design optimization and dosimetric comparison to linear accelerator-based three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT). Methods and Materials: Hypothetical ...
Purpose: To examine 10-year results of a single institution's experience with radiotherapy limited to the region of the tumor bed (i.e., accelerated partial breast irradiation, [APBI]) in selected patients treated with breast-conserving therapy (BCT) and compare them with results of matched BCT patients ...
INTRODUCTION: The objective of this study was to evaluate the safety, toxicity, and planning concerns involved in accelerated partial breast irradiation (APBI) for patients with breast cancer who have a pacemaker or an automatic implantable cardioverter-defibrillator (AICD) and who desire ...
BackgroundTo investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.MethodsBetween 2002 and 2006, 48 prospectively selected patients with early-stage breast cancer ...
Lumpectomy followed by whole breast radiation therapy (i.e. breast conservation therapy (BCT)) is the standard of care for management of early stage breast cancer. However, its utilization has not been maximized because of a number of reasons including the logistic issues associated with the 5-6weeks of radiation treatment. Also, ...
Purpose: Initial Phase I/II results using balloon brachytherapy to deliver accelerated partial breast irradiation (APBI) in 2 days in patients with early-stage breast cancer are presented. Materials and Methods: Between March 2004 and August 2007, 45 patients received adjuvant radiation therapy after lumpectomy ...
... 15. SUBJECT TERMS Partial Breast Radiation Therapy, Ultrasound Elastography, Regularization, Iterative Reweighted Least Squares, Tracked ...
DTIC Science & Technology
... Accession Number : ADA519466. Title : Ultrasound-Based Guidance for Partial Breast Irradiation Therapy. Descriptive Note : Annual summary rept. ...
Purpose: Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT). Methods and Materials: Sixty-one patients with tumors of 2 cm or less and negative axillary nodes ...
Purpose: To determine the precision of megavoltage computed tomography (MVCT)-based alignment of the seroma cavity for patients undergoing partial breast irradiation; and to determine whether accelerated partial breast irradiation (APBI) plans can be generated for TomoTherapy deliveries that ...
Purpose: To report our results with accelerated partial breast irradiation (APBI) in terms of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2/neu) status. Methods and Materials: Between February 2003 and June 2009, 209 women with early-stage breast carcinomas ...
Purpose: To examine the incidence and clinical relevance of fat necrosis after accelerated partial-breast irradiation (PBI) using interstitial high-dose-rate brachytherapy (HDR-BT) in comparison with partial-breast electron irradiation (ELE) and whole-breast irradiation (WBI). Methods and Materials: Between 1998 ...
The purpose of this study was to evaluate the capabilities of a kilovoltage (kV) on-board imager (OBI)-equipped linear accelerator in the setting of on-line verification imaging for external-beam partial breast irradiation. Available imaging techniques were optimized and assessed for image quality using a modified anthropomorphic ...
Purpose: To review our institution's experience of treating patients with the MammoSite (Cytyc Corp., Marlborough, MA) breast brachytherapy catheter to deliver accelerated partial-breast irradiation (APBI), for determining short-term treatment efficacy, cosmesis, and toxicity. Methods and Materials: From January 2000 to April ...
Physical training for increased resistance of mice to radial acceleration and lowered partial oxygen
NASA Technical Reports Server (NTRS)
Purpose: We compare the dosimetry of two techniques for three-dimensional, conformal, external beam, accelerated partial breast irradiation (3D-CPBI) in the supine position. Methods and Materials: Sixteen patients with Stage I breast cancer had PBI treatment plans generated using the multiple, noncoplanar photon ...
Purpose: To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience. Methods and Materials: A total of 199 patients with early-stage breast cancer were treated prospectively with adjuvant APBI after lumpectomy using ...
PurposeTo assess the radiation dose delivered to the heart and ipsilateral lung during accelerated partial breast brachytherapy using a MammoSite� applicator and compare to those produced by whole breast external beam radiotherapy (WBRT).Materials and methodsDosimetric analysis was conducted on patients receiving ...
BACKGROUND: Data on the risk of axillary failure (AF) after accelerated partial breast irradiation (APBI) are limited. In this study, the authors determined the rate of AF and regional lymph node failure (RNF) in patients who received various forms of APBI and identified factors that were associated with its occurrence. METHODS: In ...
Monte Carlo simulation was employed to calculate the response of TLD-100 chips under irradiation conditions such as those found during accelerated partial breast irradiation with the MammoSite radiation therapy system. The absorbed dose versus radius in the last 0.5 cm of the treated volume was also calculated, employing a resolution ...
Purpose: To investigate the incidence of, and possible factors associated with, seroma formation after intraoperative placement of the MammoSite catheter for accelerated partial breast irradiation. Methods and Materials: This study evaluated 38 patients who had undergone intraoperative MammoSite catheter placement at lumpectomy or ...
Purpose: We present our ongoing clinical experience utilizing three-dimensional (3D)-conformal radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) in patients with early-stage breast cancer treated with breast-conserving therapy. Methods and Materials: Ninety-one ...
Purpose: Several international trials are currently investigating accelerated partial breast irradiation (APBI) for patients with early-stage breast cancer. According to existing guidelines, patients with lymphatic vessel invasion (LVI) do not qualify for APBI. D2-40 (podoplanin) significantly increases the ...
Breast Cancer; Long-Term Effects Secondary to Cancer Therapy in Adults; Skin Reactions Secondary to Radiation Therapy
Imaging and local therapy are important modalities for detection and management of localized breast cancer. Improvements in screening and local therapy have contributed to reduced breast cancer-associated morbidity and mortality. The Coalition of Cancer Cooperative Groups (CCCG) convened the Scientific Leadership Council (SLC) in ...
Purpose: To assess, if and for whom, there are cost savings associated with alternate breast radiotherapy (RT) techniques when compared with the conventional external beam-based whole-breast RT with a boost (WBRT-B). Methods and Materials: Treatment planning and delivery utilization data were modeled for eight different breast RT ...
Purpose: The unique dosimetric features of proton radiotherapy make it an attractive modality for normal tissue sparing. We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI). Methods and Materials: From March 2004 to June 2005, 25 patients with ...
PURPOSE: To report 3-year toxicity, cosmesis, and efficacy of a multicenter study of external beam, accelerated partial breast irradiation (APBI) for early-stage breast cancer. METHODS AND MATERIALS: Between March 2005 and August 2006, 127 women aged ?40 years with ductal carcinoma in situ or node-negative invasive ...
BackgroundThis paper compares the calculated dose to target and normal tissues when using pencil beam (PBC), superposition/convolution (AAA) and Monte Carlo (MC) algorithms for whole breast (WBI) and accelerated partial breast irradiation (APBI) treatment plans.MethodsPlans for 10 patients who met all dosimetry ...
PURPOSE: We analyzed variables associated with long-term toxicity using three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation. METHODS AND MATERIALS: One hundred patients treated with 3D-CRT accelerated partial ...
... which is usually followed by radiation therapy): Modified radical mastectomy: In a lumpectomy , the surgeon removes the ... also be called partial mastectomy. In a modified radical mastectomy , the surgeon removes the breast, the lining ...
... Mothers were encouraged to exclusively breast-feed for at least 4 months. If mothers chose not to breast-feed exclusively or not ...
Center for Food Safety and Applied Nutrition (CFSAN)
PURPOSE: We present 4-year results from a Phase I/II trial using balloon-based brachytherapy to deliver accelerated partial breast irradiation in 2 days. MATERIALS/METHODS: Forty-five patients received breast-conserving surgery followed by adjuvant radiation therapy using a balloon-based brachytherapy applicator ...
BACKGROUND: The American Society for Radiation Oncology (ASTRO) issued a consensus statement in 2009 regarding patient selection for accelerated partial breast irradiation (APBI) following breast-conserving surgery (BCS) for breast cancer (BC). We reviewed our single-institution experience with ...
PURPOSE: To describe the first documented use of partial breast irradiation (PBI) in a patient with calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias (CREST) syndrome. METHODS AND MATERIALS: A 50-year-old woman with well-controlled CREST syndrome for 6 years was diagnosed with bilateral early-staged ...
Purpose: The present treatment planning study compared whole breast radiotherapy (WBRT) to accelerated partial breast irradiation (APBI) for different external beam techniques and geometries (e.g., free breathing [FB] and deep inspiration breath hold [DIBH]). Methods and Materials: After approval by our ...
Purpose: Accelerated partial-breast irradiation (PBI) is a new treatment paradigm for patients with early-stage breast cancer. Although PBI may lead to greater local recurrence rates, it may be cost-effective because of better tolerability and lower cost. We aim to determine the incremental cost-effectiveness of PBI compared with ...
Purpose: Radiation Therapy Oncology Group 95-17 is a prospective Phase II cooperative group trial of accelerated partial breast irradiation (APBI) alone using multicatheter brachytherapy after lumpectomy in select early-stage breast cancers. Tumor control and survival outcomes are reported. Methods and Materials: ...
... have on bone? A: Breast cancer treatment can lead to accelerated bone loss. Bone loss is a ... The problem is that this interference can also lead to accelerated bone loss. 6 ? Hormonal therapy and ...
... and 4-hydroxytamoxifen are partial antagonists, and their ... an agonist, partial antagonis, or a complete antagonist. ... role of the heparin-binding growth ...
IntroductionElectronic brachytherapy (EBT) was developed to allow accelerated partial breast irradiation to be performed in a patient procedure room with minimal shielding. This observational, nonrandomized, multicenter study evaluated EBT as a post-surgical adjuvant radiation therapy for early stage breast ...
PURPOSE: To assess the outcome of multi-catheter pulse dose rate (PDR) brachytherapy of re-irradiation for local ipsilateral breast tumour recurrence (IBTR) in regard to local control, survival, morbidity and quality of life (QoL). PATIENTS AND METHODS: Between 1999 and 2006, 39 patients were included with histologically confirmed IBTR, Karnofsky index ?80% and refusal of ...
Tracked ultrasound elastography can be used for guidance in partial breast radiotherapy by visualizing the hard scar tissue around the lumpectomy cavity. For clinical success, the elastography method needs to be robust to the sources of decorrelation betw...
National Technical Information Service (NTIS)
... during ovarian neoplasms: correlation with clinicopathology and regeneration after partial hepatectomy in rats. J Hepatol. ...
Purpose: To assess the utility of surface imaging on patient setup for accelerated partial-breast irradiation (APBI). Methods and Material: A photogrammetry system was used in parallel to APBI setup by laser and portal imaging. Surface data were acquired after laser and port-film setup for 9 patients. Surfaces were analyzed in comparison to a reference ...
Purpose: We present our initial clinical experience with proton, three-dimensional, conformal, external beam, partial-breast irradiation (3D-CPBI). Methods and Materials: Twenty patients with Stage I breast cancer were treated with proton 3D-CPBI in a Phase I/II clinical trial. Patients were followed at 3 to 4 weeks, 6 to 8 weeks, 6 months, and every 6 ...
A study published online June 5, 2010, in The Lancet shows that for some women with invasive breast cancer a single dose of radiotherapy delivered at the time of surgery may be an alternative to a standard course of external beam radiotherapy.
PURPOSE: Several recent series evaluating external beam accelerated partial breast irradiation (PBI) have reported adverse cosmetic outcomes, possibly related to large volumes of normal tissue receiving near-prescription doses. We hypothesized that delivery of external beam PBI in a single fraction to the preoperative tumor volume ...
Purpose: This prospective study examines the use of three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Four-year data on efficacy, cosmesis, and toxicity are presented. Methods: Patients with Stage O, I, or II breast cancer with lesions ...
A primary fibrosarcoma of the breast is a rare tumor. Here we report on a case of a primary fibrosarcoma of the breast that presented as a palpable left breast mass in a 47-year-old woman. The physical examination revealed a 3 cm sized, round mass in the left upper outer breast. The mammograms revealed a 3 cm ...
Breast cancer is the most common form of cancer in women. Over 75% of breast cancer patients are eligible for breast conserving therapy. Breast conserving therapy involves a lumpectomy to excise the gross tumour, followed by adjuvant radiation therapy to eradicate residual microscopic disease. Recent advances in ...
We consider estimation and variable selection in the partial linear model for censored data. The partial linear model for censored data is a direct extension of the accelerated failure time model, the latter of which is a very important alternative model to the proportional hazards model. We extend rank-based lasso-type estimators to a ...
Purpose: To determine, whether the presence of gold fiducial markers would improve the inter- and intraphysician accuracy in the delineation of the surgical cavity compared with a matched group of patients who did not receive gold fiducial markers in the setting of accelerated partial-breast irradiation (APBI). Methods and Materials: Planning CT images of ...
Accelerated partial breast irradiation (APBI) with high dose rate (HDR) brachytherapy offers an excellent compact course of radiation due to its limited number of fractions for early-stage carcinoma of breast. One of the recent devices is SAVI (strut-adjusted volume implant), which has 6, 8 or 10 peripheral source ...
Purpose: To compare dosimetrically four different techniques of accelerated partial breast irradiation (APBI) in the same patient. Methods and Materials: Thirteen post-lumpectomy interstitial brachytherapy (IB) patients underwent imaging with preimplant computed tomography (CT) in the prone and supine position. These CT scans were then ...
BackgroundAccelerated partial breast irradiation (APBI) may be used to deliver radiation to the tumor bed post-lumpectomy in eligible patients with breast cancer. Patient and tumor characteristics as well as the lumpectomy technique can influence patient eligibility for APBI. This report describes a lumpectomy ...
... (12) or by partial hepatectomy (13,14). ... Liver Cell Prolifer- ation in X-irradiated Rats After Single and Repetitive Partial Hepatectomy. J. Nat. ...
Purpose: To evaluate the role of cone-beam CT (CBCT) guidance for setup error reduction and soft tissue visualization in accelerated partial breast irradiation (APBI). Methods and Materials: Twenty patients were recruited for the delivery of radiotherapy to the postoperative cavity (3850 cGy in 10 fractions over 5 days) using an APBI ...
A Computational Framework for Breast Surgery Application to Breast Conserving Therapy David Thanoon is to achieve local control of the cancer as well as to pre- serve a breast that satisfies the woman's cosmetic concerns. While most women undergo partial mastectomy with satisfactory cosmetic results, in many ...
Purpose: To report interim cosmetic results and toxicity from a prospective study evaluating accelerated partial-breast irradiation (APBI) administered using a highly conformal external beam approach. Methods and Materials: We enrolled breast cancer patients in an institutional review board-approved prospective study of APBI using ...
We studied the roles of glycolysis and glutaminolysis following an acute reduction in mitochondrial membrane potential (?(m)) induced by the thiazolidinedione troglitazone (TRO) and compared the responses with CCCP-induced depolarization in breast cancer derived MCF-7 and MDA-MB-231 cells as well as in the MCF-10A normal breast cell line. TRO and CCCP both ...
Intensity modulated arc therapy (IMAT) is a radiation therapy technique whereby the shape of the cone beam of radiation changes as it rotates around the patient. This is in contrast to other more commonly delivered forms of advanced radiation therapy, Intensity Modulated Radiation Therapy (IMRT) or helical tomotherapy. IMRT is a radiation technique where a patient is treated with a cone beam of ...
... to determine the adjoints of the difference schemes in ... the null space of the adjoint, then the ... Alcouffe, Diffusion synthetic acceleration method for the ...
... changes, acceleration current and magnetic fields ... facets defined by partially reflective mirrors, supplemented by ... fed back through the mirror into the ...
Intrinsic radioresistance, tumor hypoxia and ability of cancer cells to undergo rapid repopulation during radiotherapy are associated with failure of radiotherapy. Tumors with low alpha/beta-ratio values or hypoxic tumors unable to undergo re-oxygenation, are unlikely to be eradicated with standard radiotherapy. Although the therapeutic efficacy of accelerated regimens based ...
to 47% of acquired data, and then using homodyne reconstruction [6]. Velocity resolution was increasedAccelerated Spiral Fourier Velocity Encoding using UNFOLD and Partial Fourier Reconstruction Joao L #12;Accelerated Spiral Fourier Velocity Encoding using UNFOLD and Partial Fourier Reconstruction Introduction
Although helical tomotherapy has been described as a means of administering accelerated partial breast irradiation, its practicality in routine whole breast irradiation as part of breast conserving therapy or chest wall irradiation has been questioned. In this technical note we describe our ...
PURPOSE: To present dosimetric assessment of CT-based high-dose rate interstitial brachytherapy of breast cancer including dose-volume histogram analysis of dose to critical structures. METHODS AND MATERIALS: Treatment plans of 49 patients with early-stage breast cancer enrolled to the Groupe Europ�en de Curieth�rapie-European Society for Therapeutic ...
It has been reported that arsenic trioxide (As2O3) is an apoptosis inducer and radiation sensitizer for various cancer cell lines. In this study of breast cancer patients, we examined the combined effect of topical As2O3 and radiation therapy on fungating and/or skin-infiltrating lesions of breast cancer. The dermatological, gastrointestinal, ...
Lab Department of Electrical Engineering University of Southern California USC Electrical Engineering Electrical Engineering Acceleration Methods � Partial Fourier � Variable-density sampling � Parallel imaging � Reduced FOV excitation � Compressed sensing � Temporal acceleration � etc. USC Electrical Engineering
Water jets are produced by vertically accelerating a rotating cone partially filled with water. It is shown that the acceleration of the parabolic meniscus results in a motion similar to that observed in a shaped explosive charge (Monroe jet). Accleration...
ObjectiveTo estimate the effect of exclusive breast feeding and partial breast feeding on infant mortality from diarrhoeal disease and acute respiratory infections in Latin America.DesignAttributable fraction analysis of national data on infant mortality and breast feeding.SettingLatin America and the ...
We recently studied the first acceleration of a spin-polarized beam through a depolarizing resonance using a partial Siberian snake. We accelerated polarized protons from 95 to 140 MeV while ramping a 10% partial Siberian snake along with the acceleration cycle. The 10% ...
Primary tumors produced by MCF-7 breast carcinoma cells over- expressing the mostly intracellular human enzyme, exhibited a 3-4 fold accelerated growth compared with tumors produced by mock-transfected cells. A more pronounced increase in tumor size and v...
There may be unacceptable risks associated with the relatively large single doses of irradiation prescribed over five days instead of over six weeks for three of the four trial arms of the NSABP39/RTOG 0413 clinical trial seeking to enlist 4,300 patients. The first arm prescribes 60 Gray (Gy) in two Gy fractions over six weeks, which is the present standard. The dose implications of the other ...
Purpose: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). Methods and Materials: Ten patients who underwent APBI were scanned daily with ...
Breast Tumor Susceptibility to Chemotherapy via Support Vector Machines Glenn M. Fung and Olvi L to generate a classifier to distinguish breast cancer pa- tients that are partial-responders to chemotherapy Support vector machines, breast cancer, chemotherapy, DNA macroar- rays 1 Introduction Support vector
The main problems with current cancer therapies, including those for breast cancer, are that they are only partially effective and highly toxic. We work on a strategy that enhances the efficacy of anti-tumor therapies, while simultaneously decreasing the ...
Partial contents: Factors associated with increased incidence/risk of human colon cancer (including general surveys of diet and cancer); Association of dietary factors with breast cancer; Studies of families with high risk of breast cancer; Factors associ...
This project aimed to study a novel gene, ADAMx, which was found in human breast tumor MCF-7. Partial sequence of ADAMx reveals that it constitutes domains characteristic of the ADAM proteins. Furthermore, ADAMx appears to be tile human analog of fertilin...
In 1996, the highlight of our research is undoubtedly the discovery of a new, large family of homeotic genes in the human breast. These genes were cloned, partially characterized, and their expression has been studied. They are activated in lumenal breast...
The main problems with current cancer therapies, including those for breast cancer, are that they are only partially effective and highly toxic. The homing peptide technology provides a new targeting strategy that aims at physically concentrating therapeu...
A slab-symmetric, partially dielectric filled, laser excited structure which maybe used to accelerate charged particles is analyzed theoretically and computationally. The fields associated with the accelerating mode are calculated, as are aspects of the resonant filling and impedance matching of the structure to the exciting laser. It ...
DOE Information Bridge
... mimics a cell's response to hypoxia which results in induction of GLUT1 which in turn accelerates aerobic or anaerobic glycolysis for tumor growth ...
As a condition of accelerated approval, subsequent randomized trials are required to verify and describe the clinical benefit of lapatinib in patients with metastatic breast cancer who have received prior treatment with trastuzumab.
... were accelerated in their M-phase entry, both by ... previous experiment to delay mitosis in an ... Individual phosphorylation site mutations in cdc25 were ...
Purpose: To present a retrospective multi-institutional experience of patients treated with the MammoSite radiation therapy system (RTS). Methods and Materials: Nine institutions participated in a pooled analysis of data evaluating the clinical experience of the MammoSite RTS for delivering accelerated partial breast irradiation. ...
Purpose: We recently presented the intraoperative radiotherapy (IORT) technique given as a reliable alternative to conventional boost radiation after breast-conserving surgery. The low crude numbers of recurrence in elderly patients led us to investigate the feasibility and the efficacy of this procedure as a sole treatment. Methods and Materials: We included 94 patients older ...
The acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at ...
High energy polarized beam collisions will open up the unique physics opportunities of studying spin effects in hard processes. However, the acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian Snake and a rf dipole that ensure stable adiabatic ...
cannabina Red-breasted merganser Mergus serrator Snow bunting Plectrophenax nivalis Partial migrants
... Male F344 rats were first subjected to partial hepatectomy, followed by a single dose of the positive control diethylnitrosamine (DEN, 100 mg/kg ...
... Tella et al. 1996) kestrels, Bay-breasted Warbler (Dendroica castanea; Stoddard 1921), and Spotted Towhee (Pipilo maculatus; Bergtold ... ...
NBII National Biological Information Infrastructure
... A panel of 14080 natural compounds from the Chinese National Center for Drug Screening has been partially screened using a yeast two-hybrid ...
... in most cases, such T cells fail to eradicate the tumor in vivo, reflecting the partial or total compromise of tumor specific immune surveillance In the ...
... Abstract : The growth of mammary tumors reflects the partial or total compromise of tumor specific immune surveillance in the tumor bearing host. ...
This report presents the results of oncoplastic surgery in three Japanese patients with breast cancer lesions involving the lower pole of the breast. Their breasts were ptotic, and their lesions were considered to be suitable for breast conservation surgery. There were treated with partial ...
PURPOSE: To report setup variations during prone accelerated partial breast irradiation (APBI). METHODS: New York University (NYU) 07-582 is an institutional review board-approved protocol of cone-beam computed tomography (CBCT) to deliver image-guided ABPI in the prone position. Eligible are postmenopausal women with pT1 ...
A low-energy electronic brachytherapy source (EBS), the model S700 Axxent x-ray device developed by Xoft Inc., has been used in high dose rate (HDR) intracavitary accelerated partial breast irradiation (APBI) as an alternative to an Ir-192 source. The prescription dose and delivery schema of the electronic brachytherapy APBI plan are ...
A low-energy electronic brachytherapy source (EBS), the model S700 Axxent� x-ray device developed by Xoft Inc., has been used in high dose rate (HDR) intracavitary accelerated partial breast irradiation (APBI) as an alternative to an Ir-192 source. The prescription dose and delivery schema of the electronic brachytherapy APBI plan ...
Purpose: To evaluate cosmetic outcome and radiation recall in the American Society of Breast Surgeons registry trial, as a function of the interval between accelerated partial breast irradiation (APBI) and initiation of chemotherapy (CTX). Methods and Materials: A total of 1440 patients at 97 institutions ...
Purpose: Accelerated partial breast irradiation (APBI) can be delivered with brachytherapy within 4-5 days compared with 5-6 weeks for conventional whole breast external beam radiotherapy. Radiation Therapy Oncology Group 95-17 is the first prospective phase I-II cooperative group trial of APBI alone after ...
Purpose: On-board cone-beam computed tomography (CBCT) provides soft tissue information that may improve setup accuracy in patients undergoing accelerated partial breast irradiation (APBI). We used CBCT to assess the residual error in soft tissue after two-dimensional kV/MV alignment based on bony anatomy. We also assessed the ...
Autologous fat transplantation was initially performed by plastic surgeons for improving facial and body contour depressions and scars. There has been long-standing interest in breast augmentation for cosmetic purposes and for the filling of defects from partial breast resection for breast cancer. In the 1980s, ...
The study investigated several physiological effects of accelerations, up to 8 G for one min., and compared the RAF mini-suit with a standard full-length suit. Positive pressure breathing and forced expiration through a partially closed glottis were studi...
The theoretical performance of diagonal conducting wall crossed-field accelerators is examined on the basis of an infinite segmentation assumption using a cross-plane averaged generalized Ohm s law for a partially ionized gas, including ion slip. The desi...
The theoretical performance of diagonal conducting wall crossed field accelerators is examined on the basis of an infinite segmentation assumption using a cross-plane averaged generalized Ohm's law for a partially ionized gas, including ion slip. The desi...
The gasdynamic partial differential equations (PDE's) governing the motion of an ablatively accelerated target (rocket) contain an inertial force term that arises mathematically from acceleration of the reference frame in which the PDE's are written, and ...
Harmonic linearization is carried out on asymmetric nonlinear differential equations for particle phase oscillations. The stability and oscillations are analyzed as functions of amplitude and any arbitrary accelerator parameter without integrating differential equations. (tr-auth)
In order to improve the speed and reproducibility of restoring the beam in the Continuous Electron Beam Accelerator Facility (CEBAF) 45 MeV injector after a full or partial shutdown of the accelerator, a program has been written using the Tcl/Tk scripting...
A preliminary assessment is presented of the potential for utilizing existing accelerator Be-target systems in the CTR Materials Program. The considerations are aimed to partially satisfy the programmatic near-term phase of the technology program. (auth)
The authors report a rare case of cutaneous angiosarcoma arising more than 5 years after excision of a 1.5 cm invasive ductal cancer of the breast. All lymph nodes were negative for metastatic breast cancer in this 68-year-old female. The patient had postoperative therapy consisting of 5040 cGy over a 5 week period using a 6 Megavolt linear ...
This lecture note reviews physics of spin motion in a synchrotron, spin depolarization mechanisms of spin resonances, and methods of overcoming the spin resonances during acceleration. Techniques used in accelerating polarized ions in the low/medium energy synchrotrons, such as the ZGS, the AGS, SATURNE, and the KEK PS and PS Booster are discussed. ...
This paper discusses the following issues relating to solving partial differential equations on array processors: domain decomposition; Schwarz methods; numerical Schwarz methods; and Fourier frequency acceleration. 5 refs. (ERA citation 14:021588)
Individual breast cancer cells in a growing primary tumor are genetically unstable and undergo somatic mutation at an accelerated rate. Primary breast tumors are therefore composed of genetically heterogeneous clones of cells. Individual clones of cells, ...
Purpose: This prospective study (Radiation Therapy Oncology Group 0319) examines the use of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Initial data on efficacy and toxicity are presented. Methods and Materials: Patients with Stage I or II ...
The SAVI and Contura breast brachytherapy applicators represent 2 recent advancements in brachytherapy technology that have expanded the number of women eligible for accelerated partial breast irradiation in the treatment of early-stage breast cancer. Early clinical experience with these 2 ...
INTRODUCTION:: Malignant breast tumors are often hormone-dependent, and to this end, both estrogen and progesterone receptors are good prognostic markers for evaluation of the outcomes after therapy. In addition, HER-2/neu, whose expression is increasingly being associated with poor prognosis of breast cancer, has predictive potential after immunotherapy. ...
Purpose: To report the local control and overall survival outcomes after lumpectomy followed by accelerated partial breast irradiation in high-risk patients as defined by the current inclusion criteria for the National Surgical Adjuvant Breast and Bowel B-39/Radiation Therapy Oncology Group 0413 Intergroup trial. ...
WSTF utilizes accelerating rate calorimetry (ARC) and differential ... when heat generated by a reaction is not removed fast enough. ... limits for fuels as a function of concentration, temperature, pressure, and partial pressures of ...
NASA Website
... Following the initial compression and partial rebound, acceleration wave forms show -1 g dwells followed by an impulsive rejoin. ...
This thesis considers the parallelization of multigrid algorithms for the solution of elliptic partial differential equations. A variety of multigrid-like algorithms are presented. Each of these algorithms accelerates the convergence of the basic multigri...
... by the end of their expected performance life ... of membrane- type fore- vacuum pump of ... required computed partial pressure values, the admixture ...
A magnetic analyzer and the methods of partial and total absorption in foils are used to measure the energy spectrum of high-current electron beams in experiments on the Impulse accelerator.
... mini-batch measurement limits ... The partials of radiationpressure acceleration with respect to KR will be 0 if tj lies in the umbra region of the eclipse ...
Aug 6, 2010... the focus is on the partial differential equations (PDEs) that arise from ... in which the majority of matrix elements are zero. ...
The formulation of sloshing dynamics for partially filled liquid of cryogenic superfluid helium 2 in
... applications, such as fighter aircraft that must withstand a wide range of variable acceleration-induced body forces. Heat transfer associated with ...
... Depreciation was based on the Accelerate Cost ... Anon., �Inorganic Zinc Coatings for Immersion (Tank ... on the Corrosion of Aluminum Alloys in Sea ...
