The present paper aims at demonstrating clinically oriented applications of the multiscale four dimensional in vivo tumor growth simulation model previously developed by our research group. To this end the effect of weekend radiotherapy treatment gaps and p53 gene status on two virtual glioblastoma tumors differing only in p53 gene status is investigated in silico. Tumor ...

... Descriptors : *LINEAR ACCELERATORS, *MEDICAL EQUIPMENT, ELECTRON ACCELERATORS, RADIOTHERAPY, ELECTRON BEAMS ...

Purpose: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers, and the current protocol of hyperfractionated accelerated radiotherapy was initiated to improve survival while limiting toxicities. Methods and Materials: All patients with ATC from 1991 to 2002 were accrued and received megavoltage radiotherapy from the ...

The physical, mechanical and dosimetric features of betatrons are described and discussed. Reference is also made to difficulties that may arise and the limitations associated with their employment as electron accelerators in radiotherapy. PMID:828281

... tempo that denies the enemy time to react accelerates culmination. Liddell Hart wrote, � Psychological ... Bellamy, Christopher. ...

Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a regimen that is now widely applied. In order to develop a regimen with increased antitumour activity, we previously established the recommended dose of neoadjuvant CPT-11 (three times weekly 90?mg?m^?2) concomitant to hyperfractionated ...

Purpose: Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial. Methods and Materials: We enrolled 15 consecutive patients to preradiation chemotherapy (CT) consisting of high-dose methotrexate, high-dose etoposide, ...

This paper outlines technological considerations in the design of accelerator facilities for medical applications. Emphasis is placed on the specific requirements for MARIA, a radioisotope and radiotherapy facility being planned in Edmonton, Canada. The m...

Jul 16, 2001... CHIP HART CHRIS HART CHRIS D HART CHRIS J HART CHRIS L ... L HART CHRISTINE HART CHRISTOPHER HART CHRISTOPHER ...

Continuous, hyperfractionated, accelerated radiotherapy (CHART) was devised to give the maximum chance of improving clinical radiotherapy and was based upon available radiobiological evidence. A pilot study, begun in 1985, has now included 210 patients. When comparison is made with previously treated cases, improved results have been ...

Continuous, hyperfractionated, accelerated radiotherapy (CHART) has given high levels of tumour control in advanced head and neck and bronchial carcinomas. In general, late changes have appeared less than after conventional radiotherapy but despite a prediction of reduced risk of spinal cord damage, two cases of radiation myelitis have ...