Platelets recruit leukocytes and mediate interactions between leukocytes and endothelial cells. Platelets have been long described as markers of transplant rejection, but the contribution of platelets to transplant rejection has not been critically examined. We now demonstrate that following T-cell initiation of allograft ...

BACKGROUND.: Currently, the donor-recipient matching process for vascularized composite tissue allotransplantation (VCTA) closely follows the standard practices for solid organ transplantation. Sensitization is considered a contraindication to VCTA. However, the role of sensitization in VCTA rejection is largely unstudied. METHODS.: Major histocompatibility-mismatched ACI ...

It was hypothesized that combined individual child vulnerability (anxious solitude) and interpersonal stress (peer exclusion) would predict the strongest responses to experimentally manipulated behavioral peer rejection. Results indicated that in a sample of 3rd graders (N = 160, 59% girls), anxious solitary excluded children displayed more behavioral manifestations of social ...

It was hypothesized that combined individual child vulnerability (anxious solitude) and interpersonal stress (peer exclusion) would predict the strongest responses to experimentally manipulated behavioral peer rejection. Results indicated that in a sample of 3rd graders (N = 160, 59% girls), anxious solitary excluded children displayed more behavioral manifestations of social ...

Allergic conjunctivitis (AC) and airway hyperreactivity exacerbate corneal allograft rejection. Because AC and airway hyperreactivity are allergic diseases of mucosal tissues, we determined whether an allergic disease of a nonmucosal tissue would affect corneal allograft rejection and whether Th2 cells alone accounted for accelerated ...

Allergic conjunctivitis (AC) and airway hyperreactivity exacerbate corneal allograft rejection. Because AC and airway hyperreactivity are allergic diseases of mucosal tissues, we determined whether an allergic disease of a nonmucosal tissue would affect corneal allograft rejection and whether Th2 cells alone accounted for accelerated ...

Chronic rejection, manifested as small airway fibrosis (obliterative bronchiolitis [OB]), is the main obstacle to long-term survival in lung transplantation. Recent studies demonstrate that the airways involved in a lung transplant are relatively hypoxic at baseline and that OB pathogenesis may be linked to ischemia induced by a transient loss of airway microvasculature. Here, ...

Chronic rejection, manifested as small airway fibrosis (obliterative bronchiolitis [OB]), is the main obstacle to long-term survival in lung transplantation. Recent studies demonstrate that the airways involved in a lung transplant are relatively hypoxic at baseline and that OB pathogenesis may be linked to ischemia induced by a transient loss of airway microvasculature. Here, ...

Cardiac allografts of (Lewis x Brown Norway) F1 rats are rejected by Lewis recipients at 7.5 days after engrafting. When recipients are presensitized with Brown Norway skin grafts at 7 days before engrafting, the cardiac grafts are rejected between 24 and 36 h (accelerated rejection, ACR). We previously ...

Acute antibody-mediated rejection is characterized by histological abnormalities such as glomerulitis, capillaritis, or thrombosis associated with presence of C4d and specific anti-donor antibodies. Reports on the association of glomerular injuries with cellular crescents in antibody-mediated rejection are not ...

Complement split products have emerged as useful markers of antibody mediated rejection in solid organ transplants. One split product, C4d, is now widely accepted as a marker for antibody mediated rejection in renal and cardiac allografts. This review summarizes the rationale for the use of C4d as a marker of ...

Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory T cells, the mean ...

It is possible to form plasma accelerating cells at interaction of acoustic waves with plasma. Cells have submicrons sizes. It is shown also, that can line up such cells along the trajectory of the accelerated particle. By the effect of such acceleration is eplained the rejection in plasma the distribution of ...

Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses. The balance between these two opposing effects is critical in the context of transplantation. Here, we report that female mice deficient in C1q (C1qa^?/?) or C3 ...

Antibody mediated rejection is a significant clinical problem encountered in a subset of renal transplant recipients. This type of rejection has a variable pathogenesis from the presence of donor specific antibodies with no overt disease to immediate hyperacute rejection and many variations between. Antibody ...

... and regulatory issues pertaining to antibody mediated rejection to facilitate and encourage the development of therapeutic modalities targeting related ...

Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to ...

A quantitative adoptive transfer assay was used to investigate the role of the spleen in cell-mediated rejection of directly vascularized heart grafts. In this assay, the cell-mediated rejection response can be examined directly by testing the capacity of inocula of T cells to effect rejection ...

Human cytomegalovirus (HCMV) infection is associated with the acceleration of transplant vascular sclerosis (TVS) and chronic allograft rejection (CR). HCMV-negative recipients of latently HCMV infected donor grafts are at highest risk for developing CMV disease. Using a rat heart transplant CR model, we have previously shown that acute rat CMV (RCMV) ...

Earlier detection of antibody-mediated rejection of kidney allografts may improve graft outcomes. Profiling of gene expression holds promise for the diagnosis and prognosis of antibody-mediated rejection. Here, we identified 730 patients who received kidney transplants during 2002�2005, including 21 patients ...

DISTURBANCE FEEDBACK TECHNIQUES FOR HYDROFOIL CRAFT USING ACCELERATION MEASUREMENTS Sergey, and the overall controller explicitly exhibits an algebraic disturbance feedback loop. A simplified hydrofoil rejection, marine systems, ship control 1. INTRODUCTION In hydrofoil control, acceleration feedback (AF

The goal of this study was to examine the role of rejection sensitivity in the relationship between social anxiety and body dysmorphic concerns. To test our hypothesis that rejection sensitivity mediates the link between social anxiety and body dysmorphic concerns, we administered self-report questionnaires to 209 student volunteers. ...

Given their self-renewing and pluripotent capabilities, human embryonic stem cells (hESCs) are well poised as a cellular source for tissue regeneration therapy. However, the host immune response against transplanted hESCs is not well characterized. In fact, controversy remains as to whether hESCs have immune-privileged properties. To address this issue, we used in vivo bioluminescent imaging to ...

To find out to what extent rejection of lungs differs from that of other organs, functional rejection of lung allografts was studied in five combinations of inbred rat strains. Rejection could be monitored accurately by perfusion scintigraphy, and equally well by chest roentgenography. The rejection of lung grafts ...

Success in cardiac transplantation has been achieved by the development of improved immunosuppressive therapies, which have led to a concomitant decrease in cardiac allograft rejection and infection. Rejection however continues to be the cause of significant morbidity and mortality particularly in the first year after cardiac transplantation. The ...

Disturbance-mediated accelerated succession in two Michigan forest types This publication is not available online. Please contact a FORT author (see sid...

cause acute graft loss after heart transplantation.1�3 Unfortu- nately, there is no non-invasive method rejection, with light-microscopic criteria of endothelial swelling, requiring specific treatment accordingGENE EXPRESSION PROFILES OF PATIENTS WITH ANTIBODY-MEDIATED REJECTION AFTER CARDIAC TRANSPLANTATION

The use of porcine organs for clinical transplantation is a promising potential solution to the shortage of human organs. Preformed anti-pig antibody is the primary cause of hyperacute rejection, while elicited antibody can contribute to subsequent �delayed� xenograft rejection. This article will review recent progress to overcome antibody ...

laboratories with two mouse tumor models (43�45). Initial experiments used transplantable murine melanoma�mediated rejection of melanoma and CD4 T cell� mediated rejection of sarcoma. This rejection generated a memory, ovarian, breast, and colon carcinoma, these antibodies have been ...

People are strongly motivated to feel accepted by others. Yet when faced with acute peer rejection they often aggress against the very peers they desire acceptance from, which may lead to further rejection. The present experiment tests three potential mediators of aggressive responses to acute peer rejection in the ...

The goal of the current study was to investigate whether peer rejection and peer victimization mediated the relation between children's aggressive behaviors and depressive symptoms. Participants were 533 fourth- and fifth-grade children (289 girls and 244 boys). Data on aggression and peer victimization were collected through teacher and peer report, ...

Four studies based on two longitudinal investigations examined the relation between social rejection and increased antisocial behavior. Found that early peer rejection (ages 6 to 8) predicted growth in aggression (at ages 10 to 12); findings were replicated in children ages 5 to 8. Rejection exacerbated antisocial development only ...

... Carlo; Metropolis-Hastings algorithm; Rejection method; Resampling. £o@esslou For IRTIS ... years ago (Metropolis et al. 1953 ...

This paper describes a short-term longitudinal study of the relation between violent victimization in the community and peer rejection among 199 children (mean age = 9.02 years) attending two urban Los Angeles area elementary schools. We used a multi-informant approach to assess victimization by community violence, peer group victimization, peer rejection, ...

The Banff 2007 classification allows chronic rejection to be differentiated based on clinicopathological characteristics evidenced by two independent immunologic mechanisms; chronic active antibody-mediated rejection and chronic active T-lymphocyte mediated rejection. However, several ...

Cyclosporine A (CsA) is a fungus-derived molecule with potent immunosuppressive activity that has been largely used to downregulate cell-mediated immune responses during transplantation. However, previous data have indicated that CsA shows immunomodulatory activity that relays on the antigen concentration and the dose of CsA used. To test the hypothesis that minimal doses of ...

The most difficult problem for accelerator mass spectrometry is the rejection of stable atomic isobars. The intensity of isobaric interference is expected to become a problem for (36) Cl measurements with the use of new high-intensity ion sources. Althoug...

In a sample of White Australians (N=273), cross-group friendship with Aboriginal Australians was associated with reduced cognitions of rejection and intergroup anxiety, and these variables fully mediated the effect of cross-group friendship on conversational avoidance of sensitive intergroup topics, active avoidance of the outgroup, and old-fashioned ...

The goals of the current study were to investigate whether peer rejection mediated the relation between aggression and depressive symptoms in childhood, and if so, whether this mediational pathway was specific to the reactive subtype of aggression. Participants were 57 second-grade children (22 girls and 35 boys). Data on reactive ...

Protection against humoral injury mediated by donor-specific antibodies (DSA), also known as accommodation, may allow for long-term allograft survival in presensitized recipients. In the present study, we determined the role of complement in renal allograft accommodation in donor skin-presensitized nonhuman primates under conventional immunosuppression. Donor skin allografts ...

Pancreas transplantation is an effective treatment option for patients with complicated diabetes mellitus. Pancreas allograft recipients are followed with laboratory markers such as serum amylase, lipase and glucose levels. Hyperglycemia may indicate severe acute rejection and has recently been associated with antibody-mediated (humoral) ...

In biopsies of renal allografts, arteriosclerosis is often more severe than expected based on the age of the donor, even without a history of rejection vasculitis. To determine whether preformed donor-specific antibodies (DSAs) may contribute to the severity of arteriosclerosis, we examined protocol biopsies from patients with (n=40) or without (n=59) DSA after excluding those ...

Function of NKG2D in natural killer cell�mediated rejection of mouse bone marrow grafts Kouetsu-resistant natural killer (NK) cells in an F1 recipient can reject parental bone marrow, and host NK cells can also, NKG2D may contribute to graft rejection in immunocompetent hosts. Natural killer (NK) cells

Examined whether maltreated children were more likely than nonmaltreated children to develop poor-quality representations of parents and whether these representations predicted children's rejection by peers. Found that maltreated children's representations were more negative/constricted and less positive/coherent than nonmaltreated children's. Representations ...

This research examined roommate responses to dependent and self-critical personality styles in the hope of finding individuals for whom rejection may be more likely. Interpersonal traits associated with dependency and self-criticism along the love and dominance axes of the Circumplex also were investigated to clarify patterns contributing to roommate ...

The humoral and cell-mediated immune responses to subsequent allografts were determined in primate recipients after concordant xenotransplantation as a bridge to allotransplantation. Heterotopic heart transplants (n = 4) were performed from cynomolgus monkeys into ABH type-matched olive baboons followed 2 weeks later by allotransplantation from ABH type-matched baboon donors. ...

The use of alpha(1,3)galactosyltransferase (alphaGT) as a method of inducing hyperacute rejection of tumors has been gaining interest recently. However, the approach is based in part on the sensitivity of each tumor line to the effects of complement lysis. Tumors expressing complement resistance factors such as membrane cofactor (CD46), decay accelerating ...

Acute allograft rejection (AAR) involves both the innate and the adaptive immune systems. As a critical pathway in peripheral T-cell differentiation and function, Notch signaling is potentially involved in the modulation of AAR, but its role in alloimmune responses has not been fully addressed. By using fully MHC-mismatched allograft transplantation model and T-cell specific ...

The diagnosis and treatment of anti-donor antibody-mediated rejection or humoral rejection (ABMR) is one of the main discussions at the moment in kidney transplantation. The search for histopathological markers that help us to diagnose ABMR has been more problematic, in contrast to the histological expression of cellular or ...

Xenotransplantation between discordant species leads to a hyperacute rejection mediated by natural antibodies, both of the IgG and IgM isotypes, activation of complement and endothelial cell activation. The combination of these mechanisms leads to a transplant survival of minutes to a few hours. Polyclonal human immunoglobulins for intravenous use (IVIg) ...

MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. Circulating miRNAs are remarkably stable in the blood. We tested whether miRNAs are also detectable in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection. We profiled urinary miRNAs of stable transplant patients and transplant patients with acute ...

Four experiments examine the emotional and attitudinal consequences of victim group rejection of a gesture of reconciliation from a transgressor group. Participants were reminded about an ingroup transgression and were told that their ingroup provided an apology (Studies 1 and 4) or an offer of repair (Studies 2 and 3). The authors varied whether the victim group ...

Although induction of CD8 T-cell responses to transplants requires CD4-cell help, how this help is transmitted remains incompletely characterized. In vitro, cognate interactions between CD4 T cells and dendritic cells (DCs) induce C3a and C5a production. CD8(+) T cells lacking C3a receptor (C3aR) and C5a receptor (C5aR) proliferate weakly to allogeneic DCs despite CD4 help, indicating that ...

Graft rejection has been defined as the mirror image of graft-versus-host disease, which is biologically characterized primarily as a Th1-type process. As such, we reasoned that graft rejection would represent a Th1 response amenable to Th2 modulation. Indeed, adoptive transfer of host Th1-type cells mediated ...

Cancer vaccines are at the forefront of novel, targeted approaches to cancer treatment. Low toxicity, the potential for circumventing drug cross-resistance, and the potential for persistence of the antitumor effect due to immunologic memory represent a mandate for accelerated clinical development. Advances in molecular immunology have suggested approaches for overcoming the ...

Experiments were done to determine whether antigen or a transfer factor escaped from millipore chambers containing viable cells with subsequent immunization of the recipient mice. Homologous nonsensitized and isologous sensitized lymphoid cells enclosed in millipore chambers were transferred to recipient mice. After appropriate time intervals, the hosts were tested by skin homografts. ...

Advances in tumor immunology are supporting the clinical implementation of several immunological approaches to cancer in the clinical setting. However, the alternate success of current immunotherapeutic regimens underscores the fact that the molecular mechanisms underlying immune-mediated tumor rejection are still poorly understood. Given the complexity of ...

A small, low-energy cyclotron has been designed and built at Berkeley for direct detection dating of /sup 14/C. The system combines the use of a negative ion source to reject /sup 14/N with the high resolution of a cyclotron to reject other background ions. In order to allow the dating of old and small samples, the present system incorporates a ...

A small, low-energy cyclotron has been designed and built at Berkeley for direct detection dating of sup 14 C. The system combines the use of a negative ion source to reject sup 14 N with the high resolution of a cyclotron to reject other background ions....

Pretreatment of human recipients with transplantation antigens isolated from blood leucocytes may be associated with prolongations of survival of skin homografts obtained from the same donors. It may also induce accelerated or white graft rejection of tra...

Rabbits were subjected to 800 r total body irradiation to render them immunoincompetent with respect to the humoral immune response. These rabbits were, however, only slightly less capable of rejecting skin allografts than nonirradiated rabbits. Furthermore, the administration of normal or specifically ``primed'' bone marrow cells (bone marrow obtained from a rabbit injected ...

The first Banff proposal for the diagnosis of pancreas rejection (Am J Transplant 2008; 8: 237) dealt primarily with the diagnosis of acute T-cell-mediated rejection (ACMR), while only tentatively addressing issues pertaining to antibody-mediated rejection (AMR). This document presents ...

Both majority and minority group members fear race-based rejection, and respond by disparaging the groups that they expect will reject them. It is not clear, however, how this process differs in minority and majority groups. Using large representative samples of White (N= 4,618) and M?ori (N= 1,163) New Zealanders, we found that perceptions of race-based ...

Peer rejection and aggression in the early school years were examined for their relevance to early starting conduct problems. The sample of 657 boys and girls from 4 geographical locations was followed from 1st through 4th grades. Peer rejection in 1st grade added incrementally to the prediction of early starting conduct problems in 3rd and 4th grades, ...

he VLT observatory operated by ESO is located on Cerro Paranal in Chile and consists of four identical 8-m telescopes and four 1.8-m VLTI Auxiliary telescopes (ATs). In order to further improve the tracking axes performance of telescopes regarding wind rejection, different control techniques have been evaluated. Ongoing investigation and studies show that by measuring the ...

The effect of certain clinically employed methods of storage, sterilization, and chemical extraction on the antigenlcity of the bone homograft was studied. The test animals were mice of the C/sub 3/Heb/Fej and C/sub 57/Bl/ 6JAX strains, in which the isogenicity of the strains was demonstrated by successfully interchanging skin grafts between strain members. The ...