The BRB Website contains other software, such as that for the generation of optimal and minimax two-stage phase II clinical trial designs and for managing dose administration for patients on accelerated titration design phase I designs. The Website also contains technical reports and PowerPoint ...
Cancer.gov
Biometric Research Branch staff, in conjunction with others at the NCI and the FDA, have developed new "accelerated titration designs" for phase I clinical trials, along with a dose-toxicity model which can be used to evaluate the toxicity data. The following gives the manuscript reference and abstract, along with brief descriptions of ...
, 87 pharmacokinetics, 87 pharmacologically guided dose escalation (PGDE) method, 91 Phase I studies 3+3 design 88 3.1.2 Pharmacologically guided dose escalation 91 3.1.3 Accelerated titration designs 92 3.4.3 Combination therapy with bivariate response 127 3.4.4 Dose escalation with two agents 129 3.5 Appendix: R
E-print Network
... Descriptors : *ELECTRON ACCELERATORS, *LINEAR ACCELERATORS, *MICROWAVES, *TRAVELING WAVE ELECTRON ACCELERATORS ...
DTIC Science & Technology
for review March 16, 2000) The monomeric VDAC channel shows an accelerated pH titration of its transport. The ``accelerated titration'' is seen in the pH-dependent current fluctuations (A), accompanied by the change) supports conclusions about cooperative titration. The means of seven ...
... Descriptors : *ELECTRON ACCELERATORS, *SOLIDS, DESIGN, LINEAR ACCELERATORS, MEASUREMENT, PHYSICAL PROPERTIES. ...
An accelerated loss of titratable acidity occurs in irradiated fruit during storage at 37 deg F. The principal acids contributing to the titratable acid values were identified and determined quantitatively. Changes in the titratable acid values were shown to be due primarily to changes in the malic acid ...
Energy Citations Database
... Accession Number : AD0637068. Title : THEORY AND DESIGN OF LINEAR ACCELERATORS: COLLECTION OF ARTICLES. ...
The design of an ablation accelerator suitable as driver for impact fusion and of a projectile to be accelerated by the accelerator is discussed. The proposed approach which offers an attractive option to accelerate the iron projectile to a hypervelocity ...
National Technical Information Service (NTIS)
... The sponsor selected trial design D in which patients were force titrated to maximal tolerated ... In the forced titration phase doses given depended on weight. ...
Center for Drug Evaluation (CDER)
The advanced automated titration system described in this report is the second in a planned series of automated instruments designed for the determination of plutonium in pure plutonium metal. It has an analysis rate of 10 min. per sample. The range of pl...
Advances in the design and performance of electrostatic accelerators since 1969 are reviewed with special emphasis on the ''forefront'' accelerators that are currently leading in voltage capability. A comparison of the acceleration tube design offered by ...
... Descriptors : *CYCLOTRON RESONANCE, *ION ACCELERATORS, DIODES ... Subject Categories : PARTICLE ACCELERATORS NUCLEAR ...
A three-hour laboratory experiment, designed for an advanced undergraduate course in instrumental analysis that illustrates the application of the gradient chamber flow-injection titration (GCFIT) method with spectrophotometric detection to determine acidity constants is presented. The procedure involves the use of an acid-base indicator to obtain the ...
ERIC Educational Resources Information Center
A laser spectrometer for the ethylenediaminetetra-acetic acid (EDTA) titration of magnesium or calcium ions that is designed around a handheld laser pointer as the source and a photoresistor as the detector is developed. Findings show that the use of the spectrometer reduces the degree of uncertainty and error in one part of the EDTA ...
Some salient information on the use of chelatochrome indicators in precipitation titrations is summarized for various metal ions. The material presented includes the cormmon or dye name assigned the indicator, its systematic chemical name, and, where existtng, the color index numbers and dye designations, and the F number of the SchultzLehmann dye ...
An automatic titrimetric apparatus is designed which is particularly suitable for titration of radioactive liquids. The apparatus comprises a bulk sampling device, a metering device, a titration vessel, a valve-controlled pneumatic system for operating the sampling and metering devices in sequence and for transferring the ...
This report discusses the analysis and design of rf cavities and rf power sources in accelerators. (LSP).
A microparticle accelerator has been devised for micrometeoroid impact and cratering simulation; the
NASA Technical Reports Server (NTRS)
Recent developments in the technology of electrostatic accelerators, linear accelerators, and cyclotrons for the acceleration of heavy ions are reviewed. (GHT)
Recent developments in the technology of electrostatic accelerators, linear accelerators, and cyclotrons for the acceleration of heavy ions are reviewed. (ERA citation 04:047251)
... Title : SOME DESIGN ASPECTS OF LINEAR ACCELERATORS USED FOR HIGH ENERGY X-RAY PRODUCTION. Corporate Author : ...
... 92 Weak Acids and Bases ... straight-forward calculations involved, acid-base titration curves were ... Paul Schatz at the University of Wisconsin has ...
... On the design of beam absorbers for the SSC - Brett Parker ... Design of an accelerating cavity for the Superconducting Super Collider Low-Energy ...
Page 1. 1 Accelerated Approval (AA) for Oncology Drug Products: ... Page 17. 17 Trial Design � Initial AA � Trial design for initial accelerated approval (AA) ...
Center for Biologics Evaluation and Research (CBER)
The China Spallation Neutron Source (CSNS) is an accelerator-based facility. The accelerator of CSNS consists of a low energy linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. The overall physics design of CSNS accelerator is described, including the design principle, the ...
NASA Astrophysics Data System (ADS)
The IFMIF 125 mA cw 40 MeV accelerators will set an intensity record. Minimization of particle loss along the accelerator is a top-level requirement and requires sophisticated design intimately relating the accelerated beam and the accelerator structure. ...
In high current (50 kA) linear induction accelerators, the accelerating gaps can excite large radial oscillations. A gap was designed that minimized the radial oscillations and reduced potential depressions. The envelope equation predicted radial oscillat...
New concepts in the design of induction accelerators and their power supplies for space and military
In an effort to further improve voltage performance of the Oak Ridge 25URC accelerator, the original acceleration tubes will be replaced with NEC compressed geometry acceleration tubes. In this paper, we report on tests in the 25URC accelerator of two prototype compressed geometry acceleration ...
DOE Information Bridge
A brief, subjective review is given of mechanisms that may be limiting electrostatic accelerator tubes to present levels of performance. Suggestions are made for attacking these limitations with the purpose of stimulating the thinking of designers and users of electrostatic accelerators.
The status of the accelerator programs in Italy, France, Germany, Sweden, United Kingdom, United States, and Japan is briefly summarized. Some of the features and design characteristics of the accelerators are given. (D.C.W.)
Recapitulation of concepts in accelerator design and discoveries made using certain types of accelerators are qualitatively provided as part of a lecture series. (D.C.W.)
... Experimental study of a back-illuminating short-pulse ... field acceleration and compact accelerator design studies, SPIE ... Longitudinal Wake Potential ...
This bibliographic study has been made from the available documents on the nowadays development of the accelerator breeder concept, aimed to fissile material production. This note describes briefly the linear accelerator principles and the mechanisms exis...
Several accelerator designs are discussed in search for a greater than 1 TeV electron accelerator. The types considered are linear accelerators, the inverse Cerenkov accelerators, the wiggler (inverse free electron laser), plasma accelerators, and the grating ...
... to efforts to reduce loss of life, injury and ... the design of the peak acceleration device (PAD ... rugged aluminum casing that provides high resistance to ...
... Experience with these accelerator systems has ... be fabricated readily by university shop facilities. ... TERMINAL BALLISTICS, EXPERIMENTAL DATA. ...
