We will determine the mechanism by which Shh signaling accelerates prostate tumor growth, identify Shh targets in prostate tumor stroma, and test the effect of individual target genes on tumor growth. The purpose of the report is to evaluate the second ye...
National Technical Information Service (NTIS)
We will determine the mechanism by which Shh signaling accelerates prostate tumor growth, identify Shh targets in prostate tumor stroma, and test the effect of individual target genes on tumor growth. The purpose of the report is to evaluate the first yea...
... In certain instances, FDA has granted accelerated approval of drugs based on the effect of the drug in significantly delaying the growth of tumors (progression ...
Center for Drug Evaluation (CDER)
Primary tumors produced by MCF-7 breast carcinoma cells over- expressing the mostly intracellular human enzyme, exhibited a 3-4 fold accelerated growth compared with tumors produced by mock-transfected cells. A more pronounced increase in tumor size and v...
We show that the metalloproteinase matrilysin dramatically accelerates the development of neu-induced mammary tumors by decreasing the time to tumor onset and increasing the percent of animals developing tumors. In addition, MMTV-matrilysin transgenic mic...
We investigated the influence of acute wounding on tumor growth in a syngeneic mouse breast cancer model. Metastatic mouse breast cancer cells (4T1) were orthotopically injected into the mammary fat pads of BALB/c mice, and animals were wounded locally by full thickness dermal incisions above the mammary fat pads or remotely above the scapula 9 days later. ...
PubMed
... mimics a cell's response to hypoxia which results in induction of GLUT1 which in turn accelerates aerobic or anaerobic glycolysis for tumor growth ...
DTIC Science & Technology
... Report Date : MAR 2006. Pagination or Media Count : 54. Abstract : Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. ...
... Report Date : MAR 2005. Pagination or Media Count : 8. Abstract : Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. ...
We present a 3D multi-cell simulation of a generic simplification of vascular tumor growth which can be easily extended and adapted to describe more specific vascular tumor types and host tissues. Initially, tumor cells proliferate as they take up the oxygen which the pre-existing vasculature supplies. The ...
PubMed Central
Chronic inflammation in humans has been implicated in the pathogenesis of several types of cancer. In animals, experimentally-induced tumor growth was found to be enhanced at sites of injury. However, a direct demonstration in vivo that an inflammatory agent applied locally at the tumor site can promote a switch into a highly ...
Erythropoietin (Epo), a known hematopoietic growth factor, has been reported to promote tumor growth and angiogenesis in Epo receptor (EpoR)-positive tumors, but its effects on EpoR-negative tumors have not been clearly shown. Here, we show that Epo accelerates the ...
Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts. Previously, it was demonstrated that periostin is mainly produced by cancer-associated fibroblasts or tumor stromal cells. In the present study, we show that periostin regulates capsule formation in ...
Energy Citations Database
Serum growth hormone (GH) was suppressed in female rats bearing mammary tumors induced by 7, 12, dimethylbenz(a)anthracene (DMBA) or N-nitrosomethylurea(NMU). Serum GH was suppressed due to treatment with a human GH analog produced by the plerocercoid stage of the tapeworm Spirometra mansonoides. Rats treated with plerocercoid growth ...
BackgroundThe unique metabolism of tumors was described many years ago by Otto Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial activity. However, �aerobic glycolysis� generates fewer ATP per glucose molecule than mitochondrial oxidative phosphorylation, so in terms of energy production, it is unclear how ...
This article provides an introduction to radiation therapy as it applies to intracranial tumors. It also provides a review of the natural growth progression of acoustic neuromas and accuracy of tumor size determination. Literature on the use of linear accelerator stereotactic radiosurgery and fractionated ...
... Accession Number : ADA541877. Title : Induction and Acceleration of Mammary Tumors by Activated P13 Kinase. Descriptive ...
Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGS-M cells have been isolated and UGSM-2 cells were transfected with t...
Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGSM cells have been isolated and UGSM-2 cells independently over-expre...
Because of the potential synergistic interaction between an anti- angiogenic aminosterol, squalamine, and other angiogenic modifiers such as vascular endothelial growth factor (VEGF) and cytokines that may be released during intermittent androgen withdraw...
Because of the potential synergistic interaction between an anti- angiogenic aminosterol, squalamine, and other angiogenic modifiers such as vascular endothelial growth factor (vEGF) and cytokines that may be released during intermittent androgen withdraw...
... growth and angiogenesis by vitamin D3 agents in murine renal cell carcinoma. ... factor/scatter factor (HGF/SF) and its receptor, c-met protooncogene, ...
Whole body X-irradiation (WBI) of experimental animals prior to transplantation of strongly immunogenic tumors frequently results in acceleration of tumor growth because of host immunosuppression. The growth of primary tumor (p < 0.01) and metastatic ...
The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion of two immunosuppressive agents; namely, interleukin-10 (IL-10) and prostaglandin ...
SummaryThe dissemination of cancer cells from a primary tumor is conventionally viewed as a unidirectional process that culminates with the metastatic colonization of distant organs. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call �tumor ...
Mathematical modeling was used to reach qualitative conclusions concerning the relative rate of local tumor control that might be achieved by using accelerated fractionation to treat only the patients with the most rapidly growing tumors, compared with the control rates that could be expected from either conventional or ...
Tumor growth and metastasis are determined by the complex interplay of factors, including those intrinsic to tumor cells and extrinsic factors associated with the tumor microenvironment. Our previous work demonstrated key roles for CD34 in the maintenance of vascular integrity and eosinophil and mast cell homing. ...
Regulation of diurnal and circadian rhythms and cell proliferation are coupled in all mammals, including humans. However, the molecular mechanisms by which diurnal and circadian rhythms regulate cell proliferation are relatively poorly understood. In this study, we report that tumor growth in nude rats bearing human steroid receptor-negative MCF-7 breast ...
It is becoming increasingly evident that discrete genetic alterations in neoplastic cells alone cannot explain multistep carcinogenesis whereby tumor cells are able to express diverse phenotypes during the complex phases of tumor development and progression. The epigenetic model posits that the host microenvironment exerts an initial, inhibitory constraint ...
The survival and growth of solid tumors is dependent on the neo- vascularization of the growing tumor mass. Prior to the vascularization of a tumor, a subpopulation of tumor cells acquire an angiogenic phenotype characterized by the production of polypept...
Most chemotherapeutic treatments use drugs that target proliferating cancer cells. Therefore, they do not affect quiescent cells which are naturally resistant. Surviving cancer cells can reactivate their cell cycles in the intervals between doses, becoming proliferative again and thus restarting tumor growth. In this work, we present a mathematical model ...
NASA Astrophysics Data System (ADS)
A small international group has recently challenged fundamental concepts in breast cancer. As a guiding principle in therapy, it has long been assumed that breast cancer growth is continuous. However, this group suggests tumor growth commonly includes extended periods of quasi-stable dormancy. Furthermore, surgery to remove the primary ...
Tumor growth and progression rely upon angiogenesis, which is regulated by pro- and antiangiogenic factors, including members of the semaphorin family. By analyzing 3 different mouse models of multistep carcinogenesis, we show here that during angiogenesis, semaphorin 3A (Sema3A) is expressed in ECs, where it serves as an endogenous inhibitor of ...
In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the tumor and surrounding stromal cells by including densities of endothelial cells and the extra-cellular matrix. When no treatment is applied the model ...
The function of p53 tumor suppressor is often altered in various human tumors predominantly through missense-mutations resulting in accumulation of mutant proteins. We revealed that expression of p53 proteins with amino-acid substitutions at codons 175 (R175H), 248 (R248W), and 273 (R273H), representing the hot-spots of mutations in various human ...
... block the growth of blood vessels to tumors ( angiogenesis ). To grow beyond a certain size, tumors must ... needed for continued growth. Treatments that interfere with angiogenesis may block tumor growth. Bevacizumab (Avastin�) is a ...
MedlinePLUS
... TITLE: Control of Breast Tumor Cell Growth by Dietary Indoles ... Control of Breast Tumor Cell Growth by Dietary Indoles DAMD17-96-1-6149 ...
Statement of Clinical RelevanceTherapies that can overcome the resistance of malignant brain tumors would be a major clinical advance. Here, we investigate the role of cAMP Phosphodiesterase-4 in stimulating brain tumor growth and the therapeutic utility of cAMP Phosphodiesterase-4 inhibition in the treatment of malignant brain ...
Acoustic cavitation is the primary mechanism of sonochemical reaction and has potential use for tumor treatment in combination with a certain sonodynamically active agent. It has been known that inducing cavitation with progressive waves is more difficult than with standing waves. This may have been limiting the sonodynamic treatment of tumors. We found ...
Regulatory T cells (Tregs) are thought to facilitate tumor development by suppressing protective antitumor immune responses. However, recent clinical and laboratory studies show that Tregs are a favorable element against cancer. In this study, we provide evidence that Tregs have both promoting and inhibiting effects on tumors, depending on the stage of ...
Cancer is thought to be a disease associated with aging. Interestingly, normal aging is driven by the production of ROS and mitochondrial oxidative stress, resulting in the cumulative accumulation of DNA damage. Here, we discuss how ROS signaling, NF?B- and HIF1-activation in the tumor microenvironment induces a form of "accelerated aging," which leads to ...
