This resource on hemostasis is from the collection of the Health Education Assets Library (HEAL). The animation portrays the interaction between fibrinogen and thrombin in hemostasis. Requires the Macromedia Flash plug-in.

AbstractBackground and PurposeMicroporous polysaccharide hemospheres (MPH) are hemostatic beads engineered from purified plant starch. MPH accelerates the natural clotting cascade by concentrating clotting factors and proteins on their surface while absorbing aqueous and low molecular weight components from blood. The purpose of this study was to determine the efficacy of MPH ...

In the event of injury to the vasculature in vertebrate organisms bleeding is stopped by a defense mechanism called hemostasis. Even though biochemical studies characterized a number of factors, classical genetic methods have not been applied to study hemostasis. We introduced zebrafish as an animal model to study genetics of ...

This animation portrays the sequence of events in hemostasis: 1. Adhesion; 2. Degranulation; 3. Aggregation; and 4. Consolidation. Requires the Macromedia Flash plug-in.

The authors study the specific nature of changes in the parameters of hemostasis in rabbits with experimental toxic liver damage. Streptokinase was injected intravenously. Toxic liver damage was induced by injections of carbon tetrachloride. The parameters studied included acceleration of lysis of the blood clot, increased fibrinolytic activity and ...

Chronic acceleration effects on animals, considering growth rate, food intake, oxygen metabolism and

In acute animal experiments coagulation hemostasis reactions and blood acid-base state were investigated when dogs were breathin hypoxis (10 percent O2) or hypoxic-hypercapnic (10 percent O2, 5 percent CO2) gas mixtures. When given the hypoxic mixture, ac...

Fucoidan extracted from brown algae (Fucus evanescens) was used for correction of immunity and hemostasis disorders in experimental endotoxemia induced by injection of LPS. Fucoidan reduced the elevated levels of proinflammatory cytokines (TNF-alpha, IL-1, IL-6) and partially arrested hypercoagulation phenomena, thus improving animal resistance to LPS. ...

Employing more than fifty dogs as experimental animals and performing extensive laboratory investigation, it was found that Hydroxyethyl starch (.9% substituted made up as a 6% solution in saline) was able to cause a hemorrhagic diathesis in mongrel canin...

The establishment of the dependence of changes in the hemostatis system of the body under the effect of low barometric pressure on the neutrophil leukocytes count and the functional state of their lysosomal apparatus involved experiments on 60 rabbits of ...

Effects of polypeptide bioregulators isolated from periodontal tissue on free-radical oxidation of lipids and the microcirculatory hemostasis during the development of chronic stress were under study. Increased reactions of lipid free-radical oxidation and blood hydrocortisone levels, denudation of dental necks were observed in animals during stress, which ...

Simulation of upper gastrointestinal (GI) hemorrhage provides the opportunity to practice endoscopic hemostasis without the risk of patient harm and time limitations. Various models have been developed to simulate an acute bleeding source in the upper GI tract to evaluate the feasibility of new endoscopic devices or to practice interventional techniques in a calm and ...

Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on ...

The standard treatment for severe traumatic injury is frequently compression and application of gauze dressing to the site of hemorrhage. However, while able to rapidly absorb pools of shed blood, gauze fails to provide strong surface (topical) hemostasis. The result can be excess hemorrhage-related morbidity and mortality. We hypothesized that cost-effective materials (based ...

The standard treatment for severe traumatic injury is frequently compression and application of gauze dressing to the site of hemorrhage. However, while able to rapidly absorb pools of shed blood, gauze fails to provide strong surface (topical) hemostasis. The result can be excess hemorrhage-related morbidity and mortality. We hypothesized that cost-effective materials (based ...

Purpose of this paper is to investigate the hemostatic capabilities of a novel vascular sealing device consisting of a balloon catheter and procoagulant. Vascular sheaths were placed percutaneously in the femoral arteries of dogs. The sealing device was evaluated using the balloon catheter alone in 6 femoral arteries and with the addition of a procoagulant in 21 femoral arteries. The balloon ...

of treatment is to correct the defect. A typical example is the replacement of factor VIII by transfu- sion VIII, the clotting factor that is deficient or defective in patients with hemophilia A, and von hemostasis may also be mediated by high plasma concentrations of factor VIII, a rate-accelerating factor

Applications of single-walled carbon nanotubes (SWNTs) in medical field imply the use of drug-coupled carbon nanotubes as well as carbon nanotubes functionalized with different chemical groups that change nanotube surface properties and interactions between nanotubes and cells. Covalent attachment of polyethylene glycol (PEG) to carboxylated single-walled carbon nanotubes (c-SWNT) is known to ...

High intensity focused ultrasound (HIFU) is believed to have great potential for inducing hemostasis in severely bleeding trauma victims. The addition of HIFU-activated biomolecular substances to the blood during treatment could significantly reduce the time required to achieve hemostasis, but such substances must remain inactive everywhere except at the ...

How do you design a peptide building block to make 2-dimentional nanowebs and 3-dimensional fibrous mats? This question has not been addressed with peptide self-assembling nanomaterials. This article describes a designed 9-residue peptide, N-Pro-Ser-Phe-Cys-Phe-Lys-Phe-Glu-Pro-C, which creates a strong fishnet-like nanostructure depending on the peptide concentrations and mechanical disruptions. ...

Previous in vitro work characterized the protease Q8009 isolated from the venom of the Australian brown snake Pseudonaja textilis textilis with Factor Xa-like activity and hemostatic properties. The purpose of the work described here characterizes the in vivo hemostatic properties in a rat model of parenchymatous organ injury. The key parameters of activity included reduction in ...

Previous in vitro work characterized the protease Q8009 isolated from the venom of the Australian brown snake Pseudonaja textilis textilis with Factor Xa-like activity and hemostatic properties. The purpose of the work described here characterizes the in vivo hemostatic properties in a rat model of parenchymatous organ injury. The key parameters of activity included reduction in ...

new treatments such as gene therapy requires appropriate animal models of hemophilia B in which. These mice have a reduced risk of an immune response and will be very useful for evaluating new therapies in a bleeding diathesis that can be life threatening. The mainstay of existing treatment is factor therapy

The use of local agents to achieve hemostasis is an old and complex subject in surgery. Their use is almost mandatory in spinal surgery. The development of new materials in chemical hemostasis is a continuous process that may potentially lead the surgeon to confusion. Moreover, the more commonly used materials have not changed in about 50 years. Using ...

PURPOSE: To evaluate the effectiveness of direct intraparenchymal injection of platelets or fresh frozen plasma (FFP) into the needle tract before cutting needle biopsy to decrease postprocedural blood loss in pigs with normal and abnormal hemostasis. MATERIALS AND METHODS: A total of 12 Yorkshire-cross pigs were anesthetized and maintained on a respirator. The pigs were ...

... in the second in vivo model of hemostasis involving hemostasis support of pigs after inducing a massive abdominal bleed by a tear in the aorta. ...

... Corporation: Thromboelastograph Coagulation Analyzer: the global coagulation test for functional analysis of hemostasis using whole blood. ...

The goal of this review is to briefly summarize the two primary pathways of hemostasis, primary hemostasis and secondary hemostasis, as well as to summarize anticoagulant mechanisms and fibrinolysis. In addition, this review will discuss pathologies of hemostasis and the mechanisms of the various drugs that are ...

This page is from a comprehensive and comprehensible tutorial in physics. Schematic drawings, questions for understanding with the answerers, and links to animations are included.

... RADIATION EFFECTS, CANCER, GROWTH(PHYSIOLOGY), HISTOLOGY, LABORATORY ANIMALS, MITOSIS, PATHOLOGY, PRODUCTION ...

Objective. To assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS). Study Design. An experimental study of an animal anterior epistaxis model. Setting. A tertiary care university hospital. Subjects and Methods. Wistar rats were randomized into 4 groups of 7 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ...

AV513 is a select fucoidan, a sulfated polysaccharide of botanical origin. It inhibits tissue factor pathway inhibitor (TFPI) activity and accelerates clotting of human hemophilia A and B plasma. In prior work, subcutaneous administration of AV513 to mice with hemophilia A improved hemostasis. The current studies were designed to evaluate potential ...

Use of intravenous laser irradiation of blood (ILIB) is considered to be the most effective method of laser therapy and its application is expedient pathogenetically in the ischemic disturbances. The aim of this study is to investigate ILIB influence with infrared laser (IL) with 860 nm wavelength on hemostasis, acid-base status (ABS) of blood in normal rabbits and after ...

Liquid fibrin sealants, together with sheet-type hemostatic agents, have been used during partial nephrectomies to secure effective hemostasis at the suture site. Using animal kidneys, we investigated which hemostatic agent might adhere most effectively to the renal tissue and serve best as a bolster. Liquid fibrin sealant alone, or in combination with a ...

This applet is an animation of an object moving with a constant acceleration in one dimension. It shows the velocity and acceleration vectors on the animation in real-time, as well as the position, velocity, and acceleration graphs as a function of time. The applet offers four distinct ...

Tissue factor (TF) initiates blood coagulation, but its expression in the vascular space requires a finite period of time. We hypothesized that targeting exogenous tissue factor to sites of vascular injury could lead to accelerated hemostasis. Since phosphatidylserine (PS) is exposed on activated cells at sites of vascular injury, we cloned the cDNA for a ...

Hibernoma is a rare, benign, slow-growing soft tissue tumor. It was named after its resemblance to the brown fat found in hibernating animals. Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before tissue diagnosis. Complete resection with meticulous hemostasis is enough for treatment. Malignant potential ...

BackgroundEndovascular technique has benefits vis-a-vis surgical access to organs with less accessible anatomical locations. To minimize surgical risk we propose a novel endovascular technique, to create parenchymal access through endovascular methods.Methodology/Principal FindingsWe have developed, manufactured and tested an endovascular catheter with a depth limiting collar and a penetrating tip ...

In the following exercises, the graph drawn is of acceleration versus time. The animation still shows the position of the particle as time progresses. There, a couple of assumptions had to be taken. An acceleration versus time graph does not provide all the information necessary for deducing position.