Cytoskeletal lattice proteins including microtubules are particularly involved in dynamic regulation of intracellular movements and activities. This paper considers possibilities and implications of biological information processing due to coupling of Dav...

... ex- ample, the cytoskeletal proteins intermediate filament ... be resistant to protein adsorption while maintaining a hydrophilic characteristic necessary ...

... phosphorylation of numerous downstream effectors like cytoskeletal and focal adhesion proteins (202, 203). While the ...

Chemicals of environmental concern are known to alter the immune system. Recent data indicate that some contaminants possess proinflammatory properties by activating neutrophils, an area of research that is still poorly investigated. We have previously documented that toxaphene activates human neutrophils to produce reactive oxygen species (ROS) and accelerates apoptosis by a ...

The network of erythrocyte cytoskeletal proteins significantly influences erythrocyte physical and biological properties. Here we show that the kinetics of erythrocyte lysis during exposure to an electric field is sensitively correlated with defects in the cytoskeletal network. Histograms compiled from single-cell electrical lysis data ...

To examine the relationship between axonal outgrowth and the delivery of cytoskeletal proteins to the growing axon tip, outgrowth was accelerated by using a conditioning nerve crush. Because slow component b (SCb) of axonal transport is the most rapid vehicle for carrying cytoskeletal proteins ...

The BCR/ABL oncogene causes human chronic myelogenous leukemia (CML), a myeloproliferative disease characterized by massive expansion of hematopoietic progenitor cells and cells of the granulocyte lineage. When transfected into murine hematopoietic cell lines, BCR/ABL causes cytokine-independence and enhances viability. There is also growing evidence that p210(BCR/ABL) affects ...

... LIPIDS, PROTEINS, MICROSCOPY, ELECTRON MICROSCOPY, PHYSIOLOGICAL ... STEADY STATE, STRESSES, COMPUTER PROGRAMS. ...

Research article Actin binding domains direct actin-binding proteins to different cytoskeletal locations

... The research plan tests the effect of drugs, which alter the conformational state of the cytoskeletal actin filaments and microtubules, on the transport ...

Cytoskeletal lattice proteins including microtubules are particularly involved in dynamic regulation of intracellular movements and activities. This paper considers possibilities and implications of biological information processing due to coupling of Davydov solitons, Frohlich coherent oscillations and other nonlinear electrodynamic phenomena to ...

The ability to control the assembly and disassembly dynamics of actin filaments is an essential property of the cellular cytoskeleton. While many different proteins are known which accelerate the polymerization of monomers into filaments or promote their disintegration, much less is known on mechanisms which guarantee the kinetic stability of the ...

Waves are a ubiquitous phenomenon in the cytoskeleton of cells crawling or spreading on a substrate. In theoretical analysis, cytoskeletal waves have been attributed to the action of molecular motors that actively cross-link cytoskeletal filaments. Motivated by recent observations of cytoskeletal waves in human neutrophils, we develop ...

Apr 21, 2011... keratin 8, two myosins, an ankyrin EST, an actin-like protein, the cytoskeletal linker (plectin) and a centriole-associated protein ...

Aug 9, 2011 ... An FtsZ cell division protein in Verrucomicrobium spinosum: implications for origins and evolution of cytoskeletal proteins in Domain ...

This resource is a detailed set of instructions for teaching a laboratory exercise demonstrating the technique of immunofluorescence in studying the spatial arrangement of proteins within cells. It may also be useful for researchers as a methodological standard for their own immunofluorescent work.

When the human red cell consumes its ATP, the cell loses its discoid character in favour of a spiculated and eventually a spherical form. This discocyte-echinocyte transformation parallels both degradation of phosphatidylinositol 4,5-bisphosphate and phosphatidic acid but not dephosphorylation of cytoskeletal proteins. Dephosphorylation of both spectrin ...

Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported in patients with Crohn's disease (CD) over 25 years ago. Although increased permeability may herald relapse to active disease, suggesting that impaired barrier function may contribute to progression, limited understanding of the mechanisms that create barrier defects in CD has made it impossible to ...

Glucocorticoids have been used for 30 years to accelerate fetal lung maturation in human pregnancy at risk of preterm delivery. Exposure to inappropriate levels of steroid, however, leads to altered maturation of the cardiovascular, metabolic and central nervous systems. The effects of betamethasone on neuronal development and function were determined in the fetal baboon brain ...

To understand lens fiber cell elongation- and differentiation-associated cytoskekeletal remodeling, here we identified and characterized the major protein components of lens fiber cell triton X-100 insoluble fraction by mass spectrometry and immunoblot analysis. This analysis identified spectrin, filensin, vimentin, tubulin, phakinin and ?-actin as major ...

The present invention relates to a cytoskeletal system composed of purified components which allow for the identification of key proteins involved in mechanotransduction. The dependent proteins, exogenous proteins in contact with the cytoskeleton network,...

The sea urchin embryo is a classical model system for studying the role of the cytoskeleton in such events as fertilization, mitosis, cleavage, cell migration and gastrulation. We have conducted an analysis of gene models derived from the Strongylocentrotus purpuratus genome assembly and have gathered strong evidence for the existence of multiple gene families encoding ...

Mouse F9 embryonic carcinoma 5.51 cells that lack the cytoskeletal protein vinculin spread poorly on

... with cytoskeletal proteins. For instance, the glycolytic enzyme, aldolase, is known to associate with the filamentous actin ... O'Reilly and Clarke, 1993). Since colocalization of aldolase and F-actin has...

... mitochondrial translocation in the cytoskeletal network, including the function and regulation of the motor proteins during oocyte maturation, fertilization, and early embryonic ... ...