in using epistasis analysis to order various other known heterochronic genes into ... epistasis anal- ysis. This molecular analysis should reveal additional ...

Analysis of Epistasis Correlation on NK Landscapes with Nearest�Neighbor Interac� tions Martin Pelikan MEDAL Report No. 2011002 February 2011 Abstract Epistasis correlation is a measure that estimates the strength of interactions between problem variables. This paper presents an empirical study of epistasis

... Results & Discussion: Synthetic Mutant Analysis Genetic analysis As described below, epistasis analysis revealed that genes encoding telomerase ...

: maternal care, QTL, mammals, genetic architecture, epistasis. During gestation and after birth epistasis Epistasis type Genotypic value Probability genotypic value D1Mit3 8 8 D3Mit194 14 128 1.22 # 10 5 overlooked because the relevance of epistasis has been generally ignored. The ability of QTL ...

... control of neuronal differentiation using genome-wide RNAi screens and genetic epistasis analysis. We have previously ...

... However, we were unable to confirm any of the two-hybrid data (see below) and did not carry on with the epistasis analysis. ...

... Analysis of Drosophila mutant phenotypes, coupled with genetic epistasis experiments (24), have identified candidates in the wingless signal ...

... line-cross analysis to compare the importance of epistasis in divergence among two sympatric Drosophila species from ... whereas crosses at an intermediate distance showed no epistasis. In D. birchii, the...

Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the variance partitioning approaches ...

and epistasis all contributed to the means of sperm length. Either an X-chromosome or a Y-chromosome effect] and dominancerdominance [l] epistasis. However, this model was not adequate (x2 =16.9, P. The in- clusion of additiverdominance [ j] epistasis did not improve the model and was removed from

is still not well understood. The main competing hypotheses include dominance, overdominance and epistasis parents. Epistasis is also frequently mentioned as a possible cause of heterosis. NC Design III, or Design the analysis of Design III to include linkage, two-locus epistasis and also the use of F3 parents. ...

pairs with negative epistasis [5�9], meaning that deleting both gene copies produces a significantly larger defect than expected from the effects of individual deletions. Negative epistasis is caused to be disfavored by natural selection. Negative epistasis be- tween functionally equivalent duplicates, regardless

Factor, eigen analysis, bio-marker interaction, PAJEK, nodes, edges, linkage disequilibrium, epistasis of the more 'bang for your buck' given by epistasis between the two original markers with respect the phenotype. It is an initial epistasis relationship network i.e. the first (major) latent pattern

orthologous genes. The role of epistasis in the manifestation of heterosis: A systems-oriented approach, pp for multiple QTL and all types of higher- order epistasis. They define a new type of heterotic effect denoted-isogenic lines reveals a significant role of epistasis, pp. 1827�1837 Albrecht E. Melchinger, Hans-Peter Piepho

In this note we measure the interdependency of bits in the encoding of a fitness function using two different invariants. The first invariant, normalized epistasis, features a strong correlation with GA-hardness, as we illustrate here with generalized Royal Road functions. The second one, bit decidability, imitates epistasis, but has the avantage of being ...

... Our epistasis analysis indicates that S6K is essential for the precocious differentiation seen in TSC clones, while loss of eIF4E does not affect the ...

... I have also identified a second novel gene in the RAS suppressor screen, called sur-9. My phenotypic analysis, epistasis analysis, mapping and ...

Research article Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis

... Page 32. Hughes et al. -9 Previous epistasis analysis had shown that these four genes function in a single pathway for telomere ...

... Genetic epistasis analysis using UV induced mutation of CAN1 suggests that Fyv6 and Polζ function independently, as an additive decrease in ...

... 1ts. Epistasis analysis revealed that genes encoding telomerase components, the Ku complex and Cdcl3p each appear to contribute separate roles ...

... EditorReceived: August 16, 2007; Accepted: August 19, 2008Keywords: Epistasis, F2 breakdown, Fundulidae, genetic incompatibility, joint scaling analysis, ... ...

In this paper, we examine the conditions that allow increased recombination to evolve in the presence of recurrent deleterious mutation. We focus on a three-locus model first studied by Feldman et al. (1980), which follows the dynamics of a modifier locus that alters the recombination rate between two loci subject to deleterious mutation. Although Feldman et al. (1980) indicated that increased ...

Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the variance partitioning approaches ...

Epistasis is fast becoming central to the understanding of the complex relationship between genotype and phenotype observed in autoimmune disease. A study in this issue of the European Journal of Immunology uses in-depth analysis of genome-wide mapping by polymorphic microsatellite markers to shed light on the genomic control of autoimmunity and ...

Motivation: Genome-wide association studies have become widely used tools to study effects of genetic variants on complex diseases. While it is of great interest to extend existing analysis methods by considering interaction effects between pairs of loci, the large number of possible tests presents a significant computational challenge. The number of computations is further ...

For different fitness mutational models, with epistasis introduced, we simulated the consequences of drift (D scenario) or mutation, selection, and drift (MSD scenario) in populations at the MSD balance subsequently subjected to bottlenecks of size N = 2, 10, 50 during 100 generations. No �conversion� of nonadditive into additive variance was observed, all components of ...

Recent advances in methodologies for testing epistatic interactions, combined with several successes in demonstrating genetic interaction effects in animal and human genetics, have rekindled interest in the role of epistatic influences on complex traits. It has even been suggested that the unacknowledged presence of epistasis vitiates the genetic dissection of human and animal ...

In an earlier paper we examined the relationship between genetic algorithms (GAs) and traditional methods of experimental design. This was motivated by an investigation into the problems caused by epistasis in the implementation and application of GAs to optimization problems. We showed how this viewpoint enables us to gain further insights into the determination of ...

Comprehensive presentation of Mendelian genetics enhanced with schematic diagrams and color photos. A sidebar of topics includes Variations to Mendel's First Law, Pedigree Analysis, Mendel's Second Law, Pleiotropy, Epistasis, Modifier Genes, Penetrance and Expressivity, Study Questions, Mendelian Genetics Overheads, Mendelian Genetics WWW Links Genetic ...

... Accepted: May 17, 2006Keywords: Coadapted gene complexes, dominance, epistasis, hybridization, inbreeding depression, line cross analysis, outbreeding depression, ... ...

Jun 16, 2011 ... Genetic epistasis analysis indicated that RAN1 acts upstream of mutations in the ethylene receptor gene family. However, the rosette-lethal ...

The fitness landscape of the graph bipartitioning problem is investigated by performing a search space analysis for several types of graphs. The analysis shows that the structure of the search space is significantly different for the types of instances studied. Moreover, with increasing epistasis, the amount of gene interactions in ...

Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci. We propose a framework for estimating and interpreting epistasis from a classical experiment that ...

Positive Epistasis Drives the Acquisition of Multidrug Resistance Sandra Trindade1,2 , Ana Sousa1 and on how they interact--epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a key theoretical

Oct. 9, 2006 Lecture 16 - Epistasis Changes in D with selection We already know that recombination. If the fitnesses depend on precise combinations of gametes, then we say there is epistasis for fitness. Epistasis there is no interaction, that is no epistasis, is as the product of the two fitnesses. One of your ...

High throughput analyses were performed to detect epistatic QTL in 17 body dimension and organ weight traits from a large F(2) pig population derived from a White Duroc and Erhualian intercross. The analyses used a nested test framework to handle multiple tests and a combined search algorithm to map epistatic QTL with empirical genome-wide thresholds derived via prior permutation. Alternative ...

Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far. Gene-gene interactions (epistasis) are largely unexplored in these GWA studies. We performed a full pair-wise genome scan in the Italian MICROS population (n?=?1201) to characterise ...

... HUMAN TOLERANCE TO ACCELERATION Prepared under Contract No. ... IN THE ANALYSIS OF HUMAN TOLERANCE TO ACCELERATION ...

Background: The study of epistasis is of great importance in statistical genetics in fields such as linkage and association analysis and QTL mapping. In an effort to classify the types of epistasis in the case of two biallelic loci Li and Reich listed and described all models in the simplest case of 0/ 1 penetrance values. However, ...

BackgroundThe error threshold puts a limit on the amount of information maintainable in Darwinian evolution. The error threshold was first formulated in terms of genotypes. However, if a genotype-phenotype map involves redundancy ("mutational neutrality"), the error threshold should be formulated in terms of phenotypes since there is no unique fittest genotype. A previous study formulated the ...

Abstract. A new framework to formulate and quantify the epistasis of a problem is proposed. It is based on Shannon�s information theory. With the framework, we suggest three epistasis-related measures: gene significance, gene epistasis, and problem epistasis. The measures are believed to be helpful to investigate ...

... fitness of such loci. If gene interactions (or epistasis) are important for determining selection values of loci ... correlated traits were permuted as blocks. Tests for Epistasis Tests for epistasis a...

Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation of deleterious mutations and thus could influence the frequency of mutants in a viral population. As ...

... warfare, joint planning, national and international ... is recirculated through the accelerator. ... LINES, *ELECTRON ACCELERATORS, HIGH POWER ...

This report discusses the analysis and design of rf cavities and rf power sources in accelerators. (LSP).

Betatron and profile oscillations in linear accelerators are discussed. Beam monitoring techniques are compared. (AIP)

between deleterious mutations (Figure 4). Epistasis, in the `population genetic sense', means that the combined effect of mutations is larger (`synergistic epistasis') or smaller (`diminishing return epistasis') than the simple product of their individual effects [23]. The average nature of epistasis is crucial

Multidimensional Epistasis and the Advantage of Sex Richard A. Watson Electronics and Computer "unidimensional epistasis," are a limited subset of possible epistatic landscapes. They claim that more general "multidimensional epistasis" usually confers a disadvantage for sex. However, the evolutionary computation (EC

, a value E roughly approximating epistasis is computed for the population. Epistasis is a measure of how strongly the #12;tness of each allele depends on the alleles of the other genes. If the epistasis is high- portional to the epistasis, the population is restricted to all individuals having the allele x sig

Distributions of epistasis in microbes fit predictions from a fitness landscape model Guillaume? Despite its simplicity, this question is central to the understanding of multilocus evolution. Epistasis (the inter- action between alleles at different loci), especially epistasis for fitness traits

joint genetic effects (epistasis) across the whole genome. The concept of epistasis1 was introduced. Three terminologies are used to describe gene- gene interactions: d Functional epistasis is a functional description that addresses the molecular interactions. d Compositional epistasis, originally defined by Bate

An End to Endless Forms: Epistasis, Phenotype Distribution Bias, and Nonuniform Evolution Elhanan represent only a small fraction of possibilities. Epistasis ensures that phenotypes are highly clustered DC (2008) An End to Endless Forms: Epistasis, Phenotype Distribution Bias, and Nonuniform Evolution

... turn increases mean fitness if there is positive epistasis. Multiple incompatibilities, each maintained by epistasis, can become coupled in the same way. In ... ...

... of regularity with and without epistasis (Chapter 3). The third problem is a challenging en- ... challenging and realistic since it has epistasis. ...

. In this paper, two types of fitness landscapes of the graph bipartitioning problem are analyzed, and a memetic algorithm -- a genetic algorithm incorporating local search -- that finds near-optimum solutions efficiently is presented. A search space analysis reveals that the fitness landscapes of geometric and non-geometric random graphs differ significantly, and within each ...

Epistasis or gene-gene interaction is a fundamental component of the genetic architecture of complex traits such as disease susceptibility. Multifactor dimensionality reduction (MDR) was developed as a nonparametric and model-free method to detect epistasis when there are no significant marginal genetic effects. However, in many studies of complex disease, ...

A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis). Statistical methods of linkage analysis are discussed under the assumption that identify by descent data from a dense set of polymorphic markers are available. ...

... Accession Number : ADP005388. Title : Hazard Analysis of Explosives by Accelerating Rate Calorimetry,. Corporate Author ...

... Title : Analysis of the Initial Human Accelerator Runs to Provide Information for Use in Injury Prediction Model Development. II. ...

... Title : Analysis of Component Contamination from Accelerated Contamination Testing of Five-Year Vuilleumier Cryocooler. ...

... Descriptors : *ACCELERATION, *FINITE ELEMENT ANALYSIS, *SHELTERS, *DYNAMIC LOADS, STRESSES, MATHEMATICAL MODELS, MASS ...

... Accession Number : ADA420006. Title : An Analysis of Airship Acceleration Dynamics for Airborne Gravimetry. Descriptive Note : Rept. ...

... Title : Accelerated Corrosion Analysis of Aluminum Armor Alloy 2519 With Nonchromate Conversion Coatings for DOD Applications. ...

Detecting gene-gene interactions or epistasis in studies of human complex diseases is a big challenge in the area of epidemiology. To address this problem, several methods have been developed, mainly in the context of data dimensionality reduction. One of these methods, Model-Based Multifactor Dimensionality Reduction, has so far mainly been applied to case-control studies. In ...

Multifactor dimensionality reduction (MDR) was developed as a nonparametric and model-free data mining method for detecting, characterizing, and interpreting epistasis in the absence of significant main effects in genetic and epidemiologic studies of complex traits such as disease susceptibility. The goal of MDR is to change the representation of the data using a constructive ...

Understanding how genetic variants impact the regulation and expression of genes is important for forging mechanistic links between variants and phenotypes in personal genomics studies. In this work, we investigate statistical interactions among variants that alter gene expression and identify 79 genes showing highly significant interaction effects consistent with genetic heterogeneity. Of the 79 ...

Motivation: In recent years, numerous genome-wide association studies have been conducted to identify genetic makeup that explains phenotypic differences observed in human population. Analytical tests on single loci are readily available and embedded in common genome analysis software toolset. The search for significant epistasis (gene�gene interactions) ...

We extend and apply a method that we have developed for deriving high-order epistatic relationships in large biochemical networks to a published genome-scale model of human metabolism. In our analysis we compute 33?328 reaction sets whose knockout synergistically disables one or more of 43 important metabolic functions. We also design minimal knockouts that remove flux through ...

We extend and apply a method that we have developed for deriving high-order epistatic relationships in large biochemical networks to a published genome-scale model of human metabolism. In our analysis we compute 33 328 reaction sets whose knockout synergistically disables one or more of 43 important metabolic functions. We also design minimal knockouts that remove flux through ...

. The epistatic variance has been introduced by Davidor as a tool for the evaluation of interdependences between genes, thus possibly giving clues about the difficulty of optimizing functions with genetic algorithms (GAs). Despite its theoretical grounding in Walsh function analysis, several studies have shown its weakness as a predictor of GAs results. In this paper, we focus ...

In this paper we examine the relationship between genetic algorithms (GAs) and traditional methods of experimental design. This was motivated by an investigation into the problem caused by epistasis in the implementation and application of GAs to optimization problems: one which has long been acknowledged to have an important influence on GA performance. Davidor [1, 2] has ...

In this paper we examine the relationship between genetic algorithms (GAs) and traditional methods of experimental design. This was motivated by an investigation into the problem caused by epistasis in the implementation and application of GAs to optimization problems: one which has long been acknowledged to have an important influence on GA performance. Davidor [1, 2] has ...

Genetic diversity is the foundation of any crop improvement program, but the cultivated Upland cotton (Gossypium hirsutum L.) has a very narrow gene pool resulting from its origin and domestication history. G. hirsutum L., the most extensively cultivated cotton species, is characterized by agronomi...

We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values. This parameterization leads ...

populations regardless of the nature of epistasis Peter D. Keightley1 and Sarah P. Otto2 1 Institute,16 . Other mechanisms that can favour recombination in large populations require certain forms of epistasis or fluctuating epistasis. For these alternative mechanisms to work epistasis must be weak, synergistic

to evolve: (i) a male-female difference in haploid epistasis, (ii) a male-female difference in cis-epistasis minus trans-epistasis in diploids, or (iii) a difference in epistasis between combinations of genes epistasis, such as migration or Hill-Robertson interfer- ence, are considered and shed ...

in a large panmictic population requires that epistasis be negative, but weak (Bar- ton 1995). Under in epistasis can cause selection against recombination even if epistasis is, on av- erage, weakly negative (Otto and Feldman 1997). The sensitivity to epistasis arises because epistasis is the ...

Mar 4, 2011 ... The acceleration used in calculating the mass is actually a calculated average acceleration with regression analysis. ...

The DNA repair genes SGS1 and MUS81 of Saccharomyces cerevisiae are thought to control alternative pathways for the repair of toxic recombination intermediates based on the fact that sgs1? mus81? synthetic lethality is suppressed in the absence of homologous recombination (HR). Although these genes appear to functionally overlap in yeast and other model systems, the specific pathways controlled by ...

... Descriptors : *AGING(MATERIALS), *SEMICONDUCTOR DEVICES, *ACCELERATED TESTING, LIFE EXPECTANCY(SERVICE LIFE), COST ...

Perturbations & trajectory of satellite subject to gravity of one celestial body by acceleration

... OUTER SPACE, *PARTICLE ACCELERATORS ... ANALYSIS, ELECTRONS, PARTICLES, HEATING, RESONANCE, OVERLAP, MASERS ...

... The analysis is performed for rail gun accelerators. ... be considered as an Ohmic load for typical circuit parameters employed in many experiments. ...

... ACCELERATION, RESISTANCE, ENERGY, NUMERICAL ANALYSIS, CAVITIES, FREE ELECTRONS, ELECTRON ENERGY, PUMPING ...

... ADD338241. Title : Evaluation of an Accelerated Weathering of Organic Coatings by Means of Lifetime Analysis,. Corporate Author : ...

... FOURIER TRANSFORMATION, ACCELERATION, THESES, OPTICAL IMAGES, MONTE CARLO METHOD, POSITION FINDING, ATMOSPHERIC ...

... Descriptors : *BLOOD CIRCULATION, *BLOOD ANALYSIS, BRAIN, PULSE RATE, WOUNDS AND INJURIES, PATHOLOGY, ACCELERATED ...

... of 26 months of operating, repairing, and maintaining the nuclear accelerator Superhilac at the Lawrence Berkeley Laboratory (LBL) are analyzed ...

... acceleration of the particle is equal to' the radial acceleration; velocity changes and the corresponding kinetic-energy changes resulting from the ...

... Accelerations and Airspeeds of One Type of Twin-Engine Transport Airplane in Commercial Operations Over a Northern Transcontinental Route. ...

... AID of Real Time r,, Acceleration and Velocity Analysis ... 3 SECRET 24-THEORETICAL GAIN WITH ACCELERATION AND VELOCITY MATCHING ...

Helicopter flight acceleration/deceleration maneuvers are quantified and put to use in the fields of

... Title : BULK ELEMENTAL ANALYSIS BY THE INELASTIC SCATTERING OF NEUTRONS PRODUCED WITH A VAN DE GRAAFF ACCELERATOR. ...

... Title : ANALYSIS OF EXPOSURE FACTORS INFLUENCING THE IMAGE QUALITY IN LINEAR ACCELERATOR RADIOGRAPHY. ...

... Accession Number : AD0267221. Title : ANALYSIS OF ENERGY EFFICIENCY OF RAIL ACCELERATORS. Corporate Author ...

, the Pennsylvania State University, Hershey Medical School. "Mapping Epistasis in Case-Control Studies: a Bayesian Sequence Alignment and Disease Epistasis Mapping" Feb 27th , 2006 Department of Computer Science, University of Minnesota. "Efficient Approaches to Multiple Sequence Alignment and Disease Epistasis Mapping

In this paper we develop an empirical methodology for studying the behavior of evolutionary algorithms based on problem generators. We then describe three generators that can be used to study the effects of epistasis on the performance of EAs. Finally, we illustrate the use of these ideas in a preliminary exploration of the effects of epistasis on simple ...

�average schemata receive exponentially increasing trials in subsequent generations.' [6] 5 The shortness and low�epistasis for the situation where schema fitness is affected by context is epistasis. The schema theorem assumes that schema fitness is not affected by context. It thus introduces the assumption of low epistasis. How ...

of critical parameters such as the form of epistasis, the rate of mutation, and the frequency of beneficial at each locus and there is no epistasis (see Fig. 1). If, however, the selective effects of an allele depend on which alleles are pres- ent at other loci (i.e. epistasis is present), disequilibrium

-offspring regression can be inflated by epistasis, genotype � environment interactions and correlations by the breeders' equation. For example, with epistasis and correlation between parental and offspring- quencies. Under this assumption, epistasis and/or shared environmental factors inflate the transient

University, East Lansing, MI 48824, USA Modularity and epistasis, as well as other aspects of genetic evolvability, and that aggravating (synergistic) epistasis among deleterious mutations facilitates overlap and sites encoding a particular trait were more tightly clustered. Net directional epistasis

.5 Epistasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 3.6 Fitness.2.1 Fitness Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 6.2.2 Epistasis parts epistasis". In particular, the EuA studied in thesis will measure the bene t of genotypic parts

... genetic drift. We use a general representation of epistasis and dominance that allows an arbitrary relation between ... A = (1 � F) Σnk=1kFk�1VA(k). Thus, epistasis inflates the expected additive variance...

selection show that recombination can be favored if epistasis is negative and weak compared to directional, we examine the joint effects of spatial heterogeneity in selection and epistasis on the evolution that including spatial heterogeneity extends the range of epistasis over which recombination can be favored

in the problem. Deception usually appears as an outcome of Epistasis. That is the interdependency among where epistasis can easily be controlled. The new perfect tree is defined as a full binary tree of some of the fitnesses of its two children. The two constraints used to create epistasis for the problem

by discussing experimental studies of group selection and aspects of pop- ulation subdivision and epistasis distinction between the arguments for and against the SBT, and in highlighting issues--such as epistasis, deny the existence of genetic drift, epistasis, pleiotropy, population subdivision, differen- tial

Investigations on the laser acceleration in vacuum are reviewed including up-date experimental results, projects of new experiments and theoretical prospects of vacuum acceleration schemes for high energies of accelerated particles. Most attention is devoted to analysis of the IFELs with focused laser beam drivers. ...

... 05-585.1 WILL POPULATION BOTTLENECKS AND MULTILOCUS EPISTASIS INCREASE ADDITIVE GENETIC VARIANCE?Michael Turelliab and N. ... v...

... TEOEOT]2.0.CO;2 THE EFFECT OF EPISTASIS ON THE EXCESS OF THE ADDITIVE AND NONADDITIVE ... which is generated by dominance, with...

... a nonlinear hump-shaped relationship when dominance and epistasis are important. Predictions for heritability (h2) are similar, ... history traits are underlain by substantial dominance or epistasis. Howe...

... 2003 doi: 10.1554/03-045 TESTING FOR EPISTASIS BETWEEN DELETERIOUS MUTATIONS IN A PARASITOID WASPAna Rivero...

... evolution, such as a lack of genetic variability, epistasis, and differential genotype-by-environment interactions. The main ... June 9, 2000; Accepted: December 5, 2000Keywords: Constraint, epistasis, ex...

Jan 22, 2011 ... Title: Origin of directional epistasis in RNA folding. Authors: Adami, C. Wilke, C. O.. Lenski, R. E.. Issue Date: 13-Jan-2002 ...

Whether interaction between genes is better represented by synergistic or antagonistic epistasis has been a focus of experimental research in bacterial population genetics. Our previous research on evolution of modifiers of epistasis in diploid systems has indicated that the strength of positive or negative epistasis should increase ...

... 2005 doi: 10.1554/04-487 NUCLEAR-MITOCHONDRIAL EPISTASIS FOR FITNESS IN SACCHAROMYCES CEREVISIAEClifford Ze...

... state (Lewin 1997). Classical Inheritance Patterns, Kernel Color & Epistasis In the classroom a discussion of monohybrid cross� ... 3 include examples of both recessive and dominant epistasis as well as m...

... 2007.00255.x GENETIC VARIATION IN PLEIOTROPY: DIFFERENTIAL EPISTASIS AS A SOURCE OF VARIATION IN THE ALLOMETRIC ... between tra...

... selection. We confirm previous results that only directional epistasis, in which genes on average reinforce or diminish ... directional selection, depending on whether positive or negative epistasis is pr...

... 1655-1663. 2004 doi: 10.1554/04-130 EPISTASIS AND THE TEMPORAL CHANGE IN THE ADDITIVE VARIANCE- ... covaria...

... 1990. 2006 doi: 10.1554/06-165.1 EPISTASIS AND DOMINANCE: EVIDENCE FOR DIFFERENTIAL EFFECTS IN LIFE- ... Ma...

... consequences. As in the case of within-genome epistasis, this cytonuclear epistasis can favor the evolutionary coadaptation of high-fitness ... of this coinheritance of the two genomes, cytonuclear epista...

... demes (contiguous natural populations). If we ignore dominance, epistasis, and linkage disequilibria, and assume two alleles per ... the distribution of allelic effects, and even interactions (epistasis) ...

... al. 2006), about which we know very little. Epistasis underlies canalization and may under particular conditions be ... al. 2006; Turelli and Barton 2006). Finding considerable epistasis at the molecular ...

For studies of DNA repair networks the sensitivity of mutants and combinations of mutants to varying forms of DNA damaging agents has formed a mainstay of genetic analysis in bacteria and yeast. Likewise, this form of epistasis analysis has proved immensely informative in DT40. Because DT40 is non-adherent, it is necessary to restrict ...

This review describes recent advances in the analysis of metabolism using quantitative genetics. It focuses on how recent metabolic quantitative trait loci (QTL) studies enhance our understanding of the genetic architecture underlying naturally variable phenotypes and the impact of this fundamental research on agriculture, specifically crop breeding. In particular, the role of ...

Consideration is given to developed and applied metnods of elemental analysis, including Rutherford backward scattering, X-ray fluorescent analysis, nuclear reactions with charged particles with the use of electrostatic accelerator. Accelerator has the fo...

Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal. The model provides the basis of an experimental method to determine the architecture of such pathways, and establishes ...

Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal. The model provides the basis of an experimental method to determine the architecture of such pathways, and establishes ...

Intensity and frequency of clear air turbulence increases as an acceleration variable of the rawinsonde observation, defined as 'adjusted acceleration', increases. Adjusted acceleration represents the magnitude of the rawinsonde acceleration without respe...

... Magnetic Analysis of a Beam of Positive Ions, Accelerated by a Voltage of 5-30 kv, After ... argon or krypton atom, or a hydrogen or nitrogen molecule. ...

... Title : Edwards Air Force Base Accelerates Flight Test Data Analysis Using MATLAB(Registered) and MathWorks(Trademark). ...

... Title : Analysis of the Initial Human Accelerator Runs to Provide Information for Use in Injury Prediction Model Development. I. Discussion. ...

... Title : Analysis of a Rail Gun Plasma Accelerator. ... Abstract : A model is developed to study the characteristics of an arc-driven rail gun. ...

... ANALYSIS OF WAKE SURVEY FOR TUINEL-FIN AND ACCELERATING- 0FIN CONFIGURATIONS FOR THE NAVAL AUXILIARY OILER (AO 177) ...

... Title : Analysis of Wake Survey for Tunnel-Fin and Accelerating-Fin Configurations for the Naval Auxiliary Oiler AO-177 Represented by Model ...

Accelerated Monte Carlo Simulation for Safety Analysis of the Advanced Airspace Concept. David Thipphavong*. NASA Ames Research Center, Moffett Field, CA, ...

... Title : A Monte Carlo Performance Analysis of Accelerated SVD (Singular Value Decomposition)-Based High Discrimination Algorithms. ...

The use of evolutionary methods to generate controllers for real-world autonomous agents has attracted recent attention. Most of the pertinent research has employed genetic algorithms or variations thereof. Recent research has indicated that the presence of epistasis drastically slows down genetic algorithms. For this reason, this paper uses a different evolutionary method, ...

BackgroundUnderstanding interactions between mutations and how they affect fitness is a central problem in evolutionary biology that bears on such fundamental issues as the structure of fitness landscapes and the evolution of sex. To date, analyses of fitness landscapes have focused either on the overall directional curvature of the fitness landscape or on the distribution of pairwise ...