Sample records for acceleration probe studying

  1. Probing electron acceleration and x-ray emission in laser-plasma accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thaury, C.; Ta Phuoc, K.; Corde, S.

    2013-06-15

    While laser-plasma accelerators have demonstrated a strong potential in the acceleration of electrons up to giga-electronvolt energies, few experimental tools for studying the acceleration physics have been developed. In this paper, we demonstrate a method for probing the acceleration process. A second laser beam, propagating perpendicular to the main beam, is focused on the gas jet few nanosecond before the main beam creates the accelerating plasma wave. This second beam is intense enough to ionize the gas and form a density depletion, which will locally inhibit the acceleration. The position of the density depletion is scanned along the interaction lengthmore » to probe the electron injection and acceleration, and the betatron X-ray emission. To illustrate the potential of the method, the variation of the injection position with the plasma density is studied.« less

  2. Study of plasma parameters in a pulsed plasma accelerator using triple Langmuir probe

    NASA Astrophysics Data System (ADS)

    Borthakur, S.; Talukdar, N.; Neog, N. K.; Borthakur, T. K.

    2018-01-01

    A Triple Langmuir Probe (TLP) has been used to study plasma parameters of a transient plasma produced in a newly developed Pulsed Plasma Accelerator system. In this experiment, a TLP with a capacitor based current mode biasing circuit was used that instantaneously gives voltage traces in an oscilloscope which are directly proportional to the plasma electron temperature and density. The electron temperature (Te) and plasma density (ne) of the plasma are measured with the help of this probe and found to be 24.13 eV and 3.34 × 1021/m3 at the maximum energy (-15 kV) of the system, respectively. An attempt was also made to analyse the time-dependent fluctuations in plasma parameters detected by the highly sensitive triple probe. In addition to this, the variation of these parameters under different discharge voltages was studied. The information obtained from these parameters is the initial diagnostics of a new device which is to be dedicated to study the impact of high heat flux plasma stream upon material surfaces inside an ITER like tokamak.

  3. Is cosmic acceleration proven by local cosmological probes?

    NASA Astrophysics Data System (ADS)

    Tutusaus, I.; Lamine, B.; Dupays, A.; Blanchard, A.

    2017-06-01

    Context. The cosmological concordance model (ΛCDM) matches the cosmological observations exceedingly well. This model has become the standard cosmological model with the evidence for an accelerated expansion provided by the type Ia supernovae (SNIa) Hubble diagram. However, the robustness of this evidence has been addressed recently with somewhat diverging conclusions. Aims: The purpose of this paper is to assess the robustness of the conclusion that the Universe is indeed accelerating if we rely only on low-redshift (z ≲ 2) observations, that is to say with SNIa, baryonic acoustic oscillations, measurements of the Hubble parameter at different redshifts, and measurements of the growth of matter perturbations. Methods: We used the standard statistical procedure of minimizing the χ2 function for the different probes to quantify the goodness of fit of a model for both ΛCDM and a simple nonaccelerated low-redshift power law model. In this analysis, we do not assume that supernovae intrinsic luminosity is independent of the redshift, which has been a fundamental assumption in most previous studies that cannot be tested. Results: We have found that, when SNIa intrinsic luminosity is not assumed to be redshift independent, a nonaccelerated low-redshift power law model is able to fit the low-redshift background data as well as, or even slightly better, than ΛCDM. When measurements of the growth of structures are added, a nonaccelerated low-redshift power law model still provides an excellent fit to the data for all the luminosity evolution models considered. Conclusions: Without the standard assumption that supernovae intrinsic luminosity is independent of the redshift, low-redshift probes are consistent with a nonaccelerated universe.

  4. 2D electron density profile measurement in tokamak by laser-accelerated ion-beam probe.

    PubMed

    Chen, Y H; Yang, X Y; Lin, C; Wang, L; Xu, M; Wang, X G; Xiao, C J

    2014-11-01

    A new concept of Heavy Ion Beam Probe (HIBP) diagnostic has been proposed, of which the key is to replace the electrostatic accelerator of traditional HIBP by a laser-driven ion accelerator. Due to the large energy spread of ions, the laser-accelerated HIBP can measure the two-dimensional (2D) electron density profile of tokamak plasma. In a preliminary simulation, a 2D density profile was reconstructed with a spatial resolution of about 2 cm, and with the error below 15% in the core region. Diagnostics of 2D density fluctuation is also discussed.

  5. Black holes are neither particle accelerators nor dark matter probes.

    PubMed

    McWilliams, Sean T

    2013-01-04

    It has been suggested that maximally spinning black holes can serve as particle accelerators, reaching arbitrarily high center-of-mass energies. Despite several objections regarding the practical achievability of such high energies, and demonstrations past and present that such large energies could never reach a distant observer, interest in this problem has remained substantial. We show that, unfortunately, a maximally spinning black hole can never serve as a probe of high energy collisions, even in principle and despite the correctness of the original diverging energy calculation. Black holes can indeed facilitate dark matter annihilation, but the most energetic photons can carry little more than the rest energy of the dark matter particles to a distant observer, and those photons are actually generated relatively far from the black hole where relativistic effects are negligible. Therefore, any strong gravitational potential could probe dark matter equally well, and an appeal to black holes for facilitating such collisions is unnecessary.

  6. Suprathermal and Solar Energetic Particles - Key questions for the Interstellar Mapping and Acceleration Probe (IMAP)

    NASA Astrophysics Data System (ADS)

    Desai, M. I.; McComas, D. J.; Christian, E. R.; Mewaldt, R. A.; Schwadron, N.

    2014-12-01

    Solar energetic particles or SEPs from suprathermal (few keV) up to relativistic (~few GeV) speeds are accelerated near the Sun in at least two ways, namely, (1) by magnetic reconnection-driven processes during solar flares resulting in impulsive SEPs and (2) at fast coronal-mass-ejection-driven shock waves that produce large gradual SEP events. Large gradual SEP events are of particular interest because the accompanying high-energy (>10s MeV) protons pose serious radiation threats to human explorers living and working outside low-Earth orbit and to technological assets such as communications and scientific satellites in space. However, a complete understanding of SEP events has eluded us primarily because their properties, as observed near Earth orbit, are smeared due to mixing and contributions from many important physical effects. Thus, despite being studied for decades, several key questions regarding SEP events remain unanswered. These include (1) What are the contributions of co-temporal flares, jets, and CME shocks to impulsive and gradual SEP events?; (2) Do flares contribute to large SEP events directly by providing high-energy particles and/or by providing the suprathermal seed population?; (3) What are the roles of ambient turbulence/waves and self-generated waves?; (4) What are the origins of the source populations and how do their temporal and spatial variations affect SEP properties?; and (5) How do diffusion and scattering during acceleration and propagation through the interplanetary medium affect SEP properties observed out in the heliosphere? This talk describes how during the next decade, inner heliospheric measurements from the Solar Probe Plus and Solar Orbiter in conjunction with high sensitivity measurements from the Interstellar Mapping and Acceleration Probe will provide the ground-truth for various models of particle acceleration and transport and address these questions.

  7. Rapid acceleration of outer radiation belt electrons associated with solar wind pressure pulse: Simulation study with Arase and Van Allen Probe observations

    NASA Astrophysics Data System (ADS)

    Hayashi, M.; Yoshizumi, M.; Saito, S.; Matsumoto, Y.; Kurita, S.; Teramoto, M.; Hori, T.; Matsuda, S.; Shoji, M.; Machida, S.; Amano, T.; Seki, K.; Higashio, N.; Mitani, T.; Takashima, T.; Kasahara, Y.; Kasaba, Y.; Yagitani, S.; Ishisaka, K.; Tsuchiya, F.; Kumamoto, A.; Matsuoka, A.; Shinohara, I.; Blake, J. B.; Fennell, J. F.; Claudepierre, S. G.

    2017-12-01

    Relativistic electron fluxes of the outer radiation belt rapidly change in response to solar wind variations. One of the shortest acceleration processes of electrons in the outer radiation belt is wave-particle interactions between drifting electrons and fast-mode waves induced by compression of the dayside magnetopause caused by interplanetary shocks. In order to investigate this process by a solar wind pressure pulse, we perform a code-coupling simulation using the GEMSIS-RB test particle simulation (Saito et al., 2010) and the GEMSIS-GM global MHD magnetosphere simulation (Matsumoto et al., 2010). As a case study, an interplanetary pressure pulse with the enhancement of 5 nPa is used as the up-stream condition. In the magnetosphere, the fast mode waves with the azimuthal electric field ( negative 𝐸𝜙 : |𝐸&;#120601;| 10 mV/m, azimuthal mode number : m ≤ 2) propagates from the dayside to nightside, interacting with electrons. From the simulation results, we derived effective acceleration model and condition : The electrons whose drift velocities vd ≥ (π/2)Vfast are accelerated efficiently. On December 20, 2016, the Arase (ERG) satellite was launched , allowing more accurate multi-point simultaneous observation with other satellites. We will compare our simulation results with observations from Arase and Van Allen Probes, and investigate the acceleration condition of relativistic electrons associated with storm sudden commencement (SSC).

  8. Probing plasma wakefields using electron bunches generated from a laser wakefield accelerator

    NASA Astrophysics Data System (ADS)

    Zhang, C. J.; Wan, Y.; Guo, B.; Hua, J. F.; Pai, C.-H.; Li, F.; Zhang, J.; Ma, Y.; Wu, Y. P.; Xu, X. L.; Mori, W. B.; Chu, H.-H.; Wang, J.; Lu, W.; Joshi, C.

    2018-04-01

    We show experimental results of probing the electric field structure of plasma wakes by using femtosecond relativistic electron bunches generated from a laser wakefield accelerator. Snapshots of laser-driven linear wakes in plasmas with different densities and density gradients are captured. The spatiotemporal evolution of the wake in a plasma density up-ramp is recorded. Two parallel wakes driven by a laser with a main spot and sidelobes are identified in the experiment and reproduced in simulations. The capability of this new method for capturing the electron- and positron-driven wakes is also shown via 3D particle-in-cell simulations.

  9. Probing gravity theory and cosmic acceleration using (in)consistency tests between cosmological data sets

    NASA Astrophysics Data System (ADS)

    Ishak-Boushaki, Mustapha B.

    2018-06-01

    Testing general relativity at cosmological scales and probing the cause of cosmic acceleration are among important objectives targeted by incoming and future astronomical surveys and experiments. I present our recent results on (in)consistency tests that can provide insights about the underlying gravity theory and cosmic acceleration using cosmological data sets. We use new statistical measures that can detect discordances between data sets when present. We use an algorithmic procedure based on these new measures that is able to identify in some cases whether an inconsistency is due to problems related to systematic effects in the data or to the underlying model. Some recent published tensions between data sets are also examined using our formalism, including the Hubble constant measurements, Planck and Large-Scale-Structure. (Work supported in part by NSF under Grant No. AST-1517768).

  10. Evaluation of a Wake Vortex Upset Model Based on Simultaneous Measurements of Wake Velocities and Probe-Aircraft Accelerations

    NASA Technical Reports Server (NTRS)

    Short, B. J.; Jacobsen, R. A.

    1979-01-01

    Simultaneous measurements were made of the upset responses experienced and the wake velocities encountered by an instrumented Learjet probe aircraft behind a Boeing 747 vortex-generating aircraft. The vortex-induced angular accelerations experienced could be predicted within 30% by a mathematical upset response model when the characteristics of the wake were well represented by the vortex model. The vortex model used in the present study adequately represented the wake flow field when the vortices dissipated symmetrically and only one vortex pair existed in the wake.

  11. Van Allen Probes Observations of Radiation Belt Acceleration associated with Solar Wind Shocks

    NASA Astrophysics Data System (ADS)

    Foster, J. C.; Wygant, J. R.; Baker, D. N.

    2017-12-01

    During a moderate solar wind shock event on 8 October 2013 the twin Van Allen Probes spacecraft observed the shock-induced electric field in the dayside magnetosphere and the response of the electron populations across a broad range of energies. Whereas other mechanisms populating the radiation belts close to Earth (L 3-5) take place on time scales of months (diffusion) or hours (storm and substorm effects), acceleration during shock events occurs on a much faster ( 1 minute) time scale. During this event the dayside equatorial magnetosphere experienced a strong dusk-dawn/azimuthal component of the electric field of 1 min duration. This shock-induced pulse accelerates radiation belt electrons for the length of time they are exposed to it creating "quasi-periodic pulse-like" enhancements in the relativistic (2 - 6 MeV) electron flux. Electron acceleration occurs on a time scale that is a fraction of their orbital drift period around the Earth. Those electrons whose drift velocity closely matches the azimuthal phase velocity of the shock-induced pulse stay in the accelerating wave as it propagates tailward and receive the largest increase in energy. Relativistic electron gradient drift velocities are energy-dependent, selecting a preferred range of energies (3-4 MeV) for the strongest enhancement. The time scale for shock acceleration is short with respect to the electron drift period ( 5 min), but long with respect to bounce and gyro periodicities. As a result, the third invariant is broken and the affected electron populations are displaced earthward experiencing an adiabatic energy gain. At radial distances tailward of the peak in phase space density, the impulsive inward displacement of the electron population produces a decrease in electron flux and a sequence of gradient drifting "negative holes".Dual spacecraft coverage of the 8 October 2013 event provided a before/after time sequence documenting shock effects.

  12. Outer planet entry probe system study. Volume 4: Common Saturn/Uranus probe studies

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Results are summarized of a common scientific probe study to explore the atmospheres of Saturn and Uranus. This was a three-month follow-on effort to the Outer Planet Entry Probe System study. The report presents: (1) a summary, conclusions and recommendations of this study, (2) parametric analysis conducted to support the two system definitions, (3) common Saturn/Uranus probe system definition using the Science Advisory Group's exploratory payload and, (4) common Saturn/Uranus probe system definition using an expanded science complement. Each of the probe system definitions consists of detailed discussions of the mission, science, system and subsystems including telecommunications, data handling, power, pyrotechnics, attitude control, structures, propulsion, thermal control and probe-to-spacecraft integration. References are made to the contents of the first three volumes where it is feasible to do so.

  13. Scanning probe acceleration microscopy (SPAM) in fluids: Mapping mechanical properties of surfaces at the nanoscale

    NASA Astrophysics Data System (ADS)

    Legleiter, Justin; Park, Matthew; Cusick, Brian; Kowalewski, Tomasz

    2006-03-01

    One of the major thrusts in proximal probe techniques is combination of imaging capabilities with simultaneous measurements of physical properties. In tapping mode atomic force microscopy (TMAFM), the most straightforward way to accomplish this goal is to reconstruct the time-resolved force interaction between the tip and surface. These tip-sample forces can be used to detect interactions (e.g., binding sites) and map material properties with nanoscale spatial resolution. Here, we describe a previously unreported approach, which we refer to as scanning probe acceleration microscopy (SPAM), in which the TMAFM cantilever acts as an accelerometer to extract tip-sample forces during imaging. This method utilizes the second derivative of the deflection signal to recover the tip acceleration trajectory. The challenge in such an approach is that with real, noisy data, the second derivative of the signal is strongly dominated by the noise. This problem is solved by taking advantage of the fact that most of the information about the deflection trajectory is contained in the higher harmonics, making it possible to filter the signal by “comb” filtering, i.e., by taking its Fourier transform and inverting it while selectively retaining only the intensities at integer harmonic frequencies. Such a comb filtering method works particularly well in fluid TMAFM because of the highly distorted character of the deflection signal. Numerical simulations and in situ TMAFM experiments on supported lipid bilayer patches on mica are reported to demonstrate the validity of this approach.

  14. Studying astrophysical particle acceleration with laser-driven plasmas

    NASA Astrophysics Data System (ADS)

    Fiuza, Frederico

    2016-10-01

    The acceleration of non-thermal particles in plasmas is critical for our understanding of explosive astrophysical phenomena, from solar flares to gamma ray bursts. Particle acceleration is thought to be mediated by collisionless shocks and magnetic reconnection. The microphysics underlying these processes and their ability to efficiently convert flow and magnetic energy into non-thermal particles, however, is not yet fully understood. By performing for the first time ab initio 3D particle-in-cell simulations of the interaction of both magnetized and unmagnetized laser-driven plasmas, it is now possible to identify the optimal parameters for the study of particle acceleration in the laboratory relevant to astrophysical scenarios. It is predicted for the Omega and NIF laser conditions that significant non-thermal acceleration can occur during magnetic reconnection of laser-driven magnetized plasmas. Electrons are accelerated by the electric field near the X-points and trapped in contracting magnetic islands. This leads to a power-law tail extending to nearly a hundred times the thermal energy of the plasma and that contains a large fraction of the magnetic energy. The study of unmagnetized interpenetrating plasmas also reveals the possibility of forming collisionless shocks mediated by the Weibel instability on NIF. Under such conditions, both electrons and ions can be energized by scattering out of the Weibel-mediated turbulence. This also leads to power-law spectra that can be detected experimentally. The resulting experimental requirements to probe the microphysics of plasma particle acceleration will be discussed, paving the way for the first experiments of these important processes in the laboratory. As a result of these simulations and theoretical analysis, there are new experiments being planned on the Omega, NIF, and LCLS laser facilities to test these theoretical predictions. This work was supported by the SLAC LDRD program and DOE Office of Science, Fusion

  15. Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution

    NASA Technical Reports Server (NTRS)

    Kolb, V.; Orgel, L. E.; Miller, S. L. (Principal Investigator)

    1994-01-01

    We have prepared a [32P]-labled oligonucleotide probe carrying a free primary amine at its 3'-terminus. This probe is used to initiate polymerization of aziridine (ethyleneimine) in aqueous solution. The nature of the oligomeric products and the kinetics of their formation are then monitored by gel electrophoresis. Our results are generally consistent with those obtained using conventional techniques. We have also investigated the effect of polyanionic templates on the rate of oligomerization of aziridine. We find that water-soluble polyanions generally accelerate the polymerization. The sodium salt of polymethacrylic acid is the most effective of the templates that we studied. The methods introduced in this paper should be applicable to a variety of polymerization reactions in aqueous solution. They should greatly simplify the screening of potentially prebiotic polymerization reactions.

  16. Laser-pump/X-ray-probe experiments with electrons ejected from a Cu(111) target: space-charge acceleration.

    PubMed

    Schiwietz, G; Kühn, D; Föhlisch, A; Holldack, K; Kachel, T; Pontius, N

    2016-09-01

    A comprehensive investigation of the emission characteristics for electrons induced by X-rays of a few hundred eV at grazing-incidence angles on an atomically clean Cu(111) sample during laser excitation is presented. Electron energy spectra due to intense infrared laser irradiation are investigated at the BESSY II slicing facility. Furthermore, the influence of the corresponding high degree of target excitation (high peak current of photoemission) on the properties of Auger and photoelectrons liberated by a probe X-ray beam is investigated in time-resolved pump and probe measurements. Strong electron energy shifts have been found and assigned to space-charge acceleration. The variation of the shift with laser power and electron energy is investigated and discussed on the basis of experimental as well as new theoretical results.

  17. Optical probing of high intensity laser interaction with micron-sized cryogenic hydrogen jets

    NASA Astrophysics Data System (ADS)

    Ziegler, Tim; Rehwald, Martin; Obst, Lieselotte; Bernert, Constantin; Brack, Florian-Emanuel; Curry, Chandra B.; Gauthier, Maxence; Glenzer, Siegfried H.; Göde, Sebastian; Kazak, Lev; Kraft, Stephan D.; Kuntzsch, Michael; Loeser, Markus; Metzkes-Ng, Josefine; Rödel, Christian; Schlenvoigt, Hans-Peter; Schramm, Ulrich; Siebold, Mathias; Tiggesbäumker, Josef; Wolter, Steffen; Zeil, Karl

    2018-07-01

    Probing the rapid dynamics of plasma evolution in laser-driven plasma interactions provides deeper understanding of experiments in the context of laser-driven ion acceleration and facilitates the interplay with complementing numerical investigations. Besides the microscopic scales involved, strong plasma (self-)emission, predominantly around the harmonics of the driver laser, often complicates the data analysis. We present the concept and the implementation of a stand-alone probe laser system that is temporally synchronized to the driver laser, providing probing wavelengths beyond the harmonics of the driver laser. The capability of this system is shown during a full-scale laser proton acceleration experiment using renewable cryogenic hydrogen jet targets. For further improvements, we studied the influence of probe color, observation angle of the probe and temporal contrast of the driver laser on the probe image quality.

  18. Update on the Fire (solar probe) mission study

    NASA Technical Reports Server (NTRS)

    Jones, W. Veron; Forman, Miriam A.

    1995-01-01

    Since mid-1994 the U.S. and Russia have been studying the technical feasibility of a joint solar probe mission as part of the 'Fire and Ice' concept to explore close to the Sun, and Pluto, together. In the current concept of the 'Fire' mission, separate spacecraft built by each country would be launched together, fly by Jupiter to shed orbital angular momentum and achieve a solar polar orbit, and arrive 3.6 years later at 4 and 10 R(sub s). The Fire mission would measure basic parameters of the modes of energy and momentum flow and transfer to the coronal plasma that are not observable remotely. Specifically, measurement of magnetic fields, waves, suprathermal particles, and critical features of the plasma particle composition and distribution function would be made from 4 to 30 R(sub s) where the solar wind is known to be accelerated. In addition, the Fire spacecraft should image coronal structures unambiguously and relate the underlying and flown-through structures to plasma characteristics measured in situ. Each country is developing a backup plan to pursue the solar probe objectives alone if the other side is unable to carry out its mission.

  19. Vibrational dynamics of hydrogen-bonded complexes in solutions studied with ultrafast infrared pump-probe spectroscopy.

    PubMed

    Banno, Motohiro; Ohta, Kaoru; Yamaguchi, Sayuri; Hirai, Satori; Tominaga, Keisuke

    2009-09-15

    In aqueous solution, the basis of all living processes, hydrogen bonding exerts a powerful effect on chemical reactivity. The vibrational energy relaxation (VER) process in hydrogen-bonded complexes in solution is sensitive to the microscopic environment around the oscillator and to the geometrical configuration of the hydrogen-bonded complexes. In this Account, we describe the use of time-resolved infrared (IR) pump-probe spectroscopy to study the vibrational dynamics of (i) the carbonyl CO stretching modes in protic solvents and (ii) the OH stretching modes of phenol and carboxylic acid. In these cases, the carbonyl group acts as a hydrogen-bond acceptor, whereas the hydroxyl group acts as a hydrogen-bond donor. These vibrational modes have different properties depending on their respective chemical bonds, suggesting that hydrogen bonding may have different mechanisms and effects on the VER of the CO and OH modes than previously understood. The IR pump-probe signals of the CO stretching mode of 9-fluorenone and methyl acetate in alcohol, as well as that of acetic acid in water, include several components with different time constants. Quantum chemical calculations indicate that the dynamical components are the result of various hydrogen-bonded complexes that form between solute and solvent molecules. The acceleration of the VER is due to the increasing vibrational density of states caused by the formation of hydrogen bonds. The vibrational dynamics of the OH stretching mode in hydrogen-bonded complexes were studied in several systems. For phenol-base complexes, the decay time constant of the pump-probe signal decreases as the band peak of the IR absorption spectrum shifts to lower wavenumbers (the result of changing the proton acceptor). For phenol oligomers, the decay time constant of the pump-probe signal decreases as the probe wavenumber decreases. These observations show that the VER time strongly correlates with the strength of hydrogen bonding. This

  20. Electric field measurement in microwave discharge ion thruster with electro-optic probe.

    PubMed

    Ise, Toshiyuki; Tsukizaki, Ryudo; Togo, Hiroyoshi; Koizumi, Hiroyuki; Kuninaka, Hitoshi

    2012-12-01

    In order to understand the internal phenomena in a microwave discharge ion thruster, it is important to measure the distribution of the microwave electric field inside the discharge chamber, which is directly related to the plasma production. In this study, we proposed a novel method of measuring a microwave electric field with an electro-optic (EO) probe based on the Pockels effect. The probe, including a cooling system, contains no metal and can be accessed in the discharge chamber with less disruption to the microwave distribution. This method enables measurement of the electric field profile under ion beam acceleration. We first verified the measurement with the EO probe by a comparison with a finite-difference time domain numerical simulation of the microwave electric field in atmosphere. Second, we showed that the deviations of the reflected microwave power and the beam current were less than 8% due to inserting the EO probe into the ion thruster under ion beam acceleration. Finally, we successfully demonstrated the measurement of the electric-field profile in the ion thruster under ion beam acceleration. These measurements show that the electric field distribution in the thruster dramatically changes in the ion thruster under ion beam acceleration as the propellant mass flow rate increases. These results indicate that this new method using an EO probe can provide a useful guide for improving the propulsion of microwave discharge ion thrusters.

  1. ESA Venus Entry Probe Study

    NASA Technical Reports Server (NTRS)

    vandenBerg, M. L.; Falkner, P.; Phipps, A.; Underwood, J. C.; Lingard, J. S.; Moorhouse, J.; Kraft, S.; Peacock, A.

    2005-01-01

    The Venus Entry Probe is one of ESA s Technology Reference Studies (TRS). The purpose of the Technology Reference Studies is to provide a focus for the development of strategically important technologies that are of likely relevance for future scientific missions. The aim of the Venus Entry Probe TRS is to study approaches for low cost in-situ exploration of Venus and other planetary bodies with a significant atmosphere. In this paper, the mission objectives and an outline of the mission concept of the Venus Entry Probe TRS are presented.

  2. Recent Progress on Understanding SEP Acceleration and Transport

    NASA Astrophysics Data System (ADS)

    Cohen, C.

    2017-12-01

    Joint observations between near-Earth spacecraft and the twin STEREO spacecraft have allowed new examinations of the longitudinal extent of solar energetic particles (SEPs). Although the radial dependence will not be measured in detail until Parker Solar Probe and Solar Orbiter have launched, recent developments in modeling SEP acceleration and transport have revealed interesting dependences on magnetic field configurations and the characteristics of seed particle populations. This talk will review recent SEP in-situ observations along with theoretical studies and their implications for our understanding of SEP acceleration and transport in the inner heliosphere and our expectations for upcoming Solar Orbiter and Parker Solar Probe observations.

  3. The Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal plasma (ECT) Suite: Upcoming Opportunties for Testing Radiation Belt Acceleration Mechanisms

    NASA Astrophysics Data System (ADS)

    Spence, Harlan; Reeves, Geoffrey

    2012-07-01

    The Radiation Belt Storm Probes (RBSP) mission will launch in late summer 2012 and begin its exploration of acceleration and dynamics of energetic particles in the inner magnetosphere. In this presentation, we discuss opportunities afforded by the RBSP Energetic Particle, Composition, and Thermal plasma (ECT) instrument suite to advance our understanding of acceleration processes in the radiation belts. The RBSP-ECT instrument suite comprehensively measures the electron and major ion populations of the inner magnetosphere, from the lowest thermal plasmas of the plasmasphere, to the hot plasma of the ring current, to the relativistic populations of the radiation belts. Collectively, the ECT measurements will reveal the complex cross-energy coupling of these colocated particle populations, which along with concurrent RBSP wave measurements, will permit various wave-particle acceleration mechanisms to be tested. We review the measurement capabilities of the RBSP-ECT instrument suite, and demonstrate several examples of how these measurements will be used to explore candidate acceleration mechanisms and dynamics of radiation belt particles.

  4. Interstellar Mapping and Acceleration Probe (IMAP)

    NASA Astrophysics Data System (ADS)

    Schwadron, Nathan

    2016-04-01

    Our piece of cosmic real-estate, the heliosphere, is the domain of all human existence - an astrophysical case-history of the successful evolution of life in a habitable system. By exploring our global heliosphere and its myriad interactions, we develop key physical knowledge of the interstellar interactions that influence exoplanetary habitability as well as the distant history and destiny of our solar system and world. IBEX was the first mission to explore the global heliosphere and in concert with Voyager 1 and Voyager 2 is discovering a fundamentally new and uncharted physical domain of the outer heliosphere. In parallel, Cassini/INCA maps the global heliosphere at energies (~5-55 KeV) above those measured by IBEX. The enigmatic IBEX ribbon and the INCA belt were unanticipated discoveries demonstrating that much of what we know or think we understand about the outer heliosphere needs to be revised. The next quantum leap enabled by IMAP will open new windows on the frontier of Heliophysics at a time when the space environment is rapidly evolving. IMAP with 100 times the combined resolution and sensitivity of IBEX and INCA will discover the substructure of the IBEX ribbon and will reveal in unprecedented resolution global maps of our heliosphere. The remarkable synergy between IMAP, Voyager 1 and Voyager 2 will remain for at least the next decade as Voyager 1 pushes further into the interstellar domain and Voyager 2 moves through the heliosheath. The "A" in IMAP refers to acceleration of energetic particles. With its combination of highly sensitive pickup and suprathermal ion sensors, IMAP will provide the species and spectral coverage as well as unprecedented temporal resolution to associate emerging suprathermal tails with interplanetary structures and discover underlying physical acceleration processes. These key measurements will provide what has been a critical missing piece of suprathermal seed particles in our understanding of particle acceleration to high

  5. Changes in mesenteric, renal, and aortic flows with +Gx acceleration

    NASA Technical Reports Server (NTRS)

    Stone, H. L.; Erickson, H. H.; Sandler, H.

    1974-01-01

    Previous studies in man and dogs have indicated that the splanchnic bed might contribute to the maintenance of arterial pressure during +Gx acceleration. Eight mongrel dogs were chronically instrumented with Doppler flow probes around the superior mesenteric (SMA) and renal arteries (RA) as well as the terminal aorta (TA). A solid-state pressure transducer was placed in the aorta distal to the flow probe. Using alpha-chloralose anesthesia following a 2-4 week recovery period, the animals were subjected to 120 sec at levels of 5, 10 and 15 +Gx acceleration on a 7.6-m radius centrifuge. The results indicate that both an active component and a mechanical component contribute to the maintenance of arterial pressure during +Gx acceleration.

  6. What Is a pH Probe Study?

    MedlinePlus

    What is a pH Probe Study ? What is pH a probe study? M easuring the pH in the esophagus helps determine whether or not acid is coming up from the stomach. A pH probe study is usually done in patients where ...

  7. Advanced Accelerators: Particle, Photon and Plasma Wave Interactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Ronald L.

    2017-06-29

    The overall objective of this project was to study the acceleration of electrons to very high energies over very short distances based on trapping slowly moving electrons in the fast moving potential wells of large amplitude plasma waves, which have relativistic phase velocities. These relativistic plasma waves, or wakefields, are the basis of table-top accelerators that have been shown to accelerate electrons to the same high energies as kilometer-length linear particle colliders operating using traditional decades-old acceleration techniques. The accelerating electrostatic fields of the relativistic plasma wave accelerators can be as large as GigaVolts/meter, and our goal was to studymore » techniques for remotely measuring these large fields by injecting low energy probe electron beams across the plasma wave and measuring the beam’s deflection. Our method of study was via computer simulations, and these results suggested that the deflection of the probe electron beam was directly proportional to the amplitude of the plasma wave. This is the basis of a proposed diagnostic technique, and numerous studies were performed to determine the effects of changing the electron beam, plasma wave and laser beam parameters. Further simulation studies included copropagating laser beams with the relativistic plasma waves. New interesting results came out of these studies including the prediction that very small scale electron beam bunching occurs, and an anomalous line focusing of the electron beam occurs under certain conditions. These studies were summarized in the dissertation of a graduate student who obtained the Ph.D. in physics. This past research program has motivated ideas for further research to corroborate these results using particle-in-cell simulation tools which will help design a test-of-concept experiment in our laboratory and a scaled up version for testing at a major wakefield accelerator facility.« less

  8. Future HEP Accelerators: The US Perspective

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhat, Pushpalatha; Shiltsev, Vladimir

    2015-11-02

    Accelerator technology has advanced tremendously since the introduction of accelerators in the 1930s, and particle accelerators have become indispensable instruments in high energy physics (HEP) research to probe Nature at smaller and smaller distances. At present, accelerator facilities can be classified into Energy Frontier colliders that enable direct discoveries and studies of high mass scale particles and Intensity Frontier accelerators for exploration of extremely rare processes, usually at relatively low energies. The near term strategies of the global energy frontier particle physics community are centered on fully exploiting the physics potential of the Large Hadron Collider (LHC) at CERN throughmore » its high-luminosity upgrade (HL-LHC), while the intensity frontier HEP research is focused on studies of neutrinos at the MW-scale beam power accelerator facilities, such as Fermilab Main Injector with the planned PIP-II SRF linac project. A number of next generation accelerator facilities have been proposed and are currently under consideration for the medium- and long-term future programs of accelerator-based HEP research. In this paper, we briefly review the post-LHC energy frontier options, both for lepton and hadron colliders in various regions of the world, as well as possible future intensity frontier accelerator facilities.« less

  9. PW-class laser-driven super acceleration systems in underdense plasmas

    NASA Astrophysics Data System (ADS)

    Yano, Masahiro; Zhidkov, Alexei; Kodama, Ryosuke

    2017-10-01

    Probing laser driven super-acceleration systems can be important tool to understand physics related to vacuum, space time, and particle acceleration. We show two proposals to probe the systems through Hawking-like effect using PW class lasers and x-ray free electron lasers. For that we study the interaction of ultrahigh intense laser pulses with intensity 1022 -1024 W/cm2 and underdense plasmas including ion motion and plasma radiation for the first time. While the acceleration w a0ωp /ωL in a wake is not maximal, the pulse propagation is much stable. The effect is that a constantly accelerated detector with acceleration w sees a boson's thermal bath at temperature ℏw / 2 πkB c . We present two designs for x-ray scattering from highly accelerated electrons produced in the plasma irradiated by intense laser pulses for such detection. Properly chosen observation angles enable us to distinguish spectral broadening from Doppler shift with a reasonable photon number. Also, ion motion and radiation damping on the interaction are investigated via fully relativistic 3D particle-in-cell simulation. We observe high quality electron bunches under super-acceleration when transverse plasma waves are excited by ponderomotive force producing plasma channel.

  10. The Interstellar Mapping and Acceleration Probe - A Mission to Discover the Origin of Particle Acceleration and its Fundamental Connection to the Global Interstellar Interaction

    NASA Astrophysics Data System (ADS)

    Schwadron, N.

    2017-12-01

    Our piece of cosmic real-estate, the heliosphere, is the domain of all human existence - an astrophysical case-history of the successful evolution of life in a habitable system. The Interstellar Boundary Explorer (IBEX) was the first mission to explore the global heliosphere and in concert with Voyager 1 and Voyager 2 is discovering a fundamentally new and uncharted physical domain of the outer heliosphere. In parallel, Cassini/INCA maps the global heliosphere at energies ( 5-55 keV) above those measured by IBEX. The enigmatic IBEX ribbon and the INCA belt were unanticipated discoveries demonstrating that much of what we know or think we understand about the outer heliosphere needs to be revised. The global structure of the heliosphere is highly complex and influenced by competing factors ranging from the local interstellar magnetic field, suprathermal populations both within and beyond the heliopause, and the detailed flow properties of the LISM. Global heliospheric structure and microphysics in turn influences the acceleration of energetic particles and creates feedbacks that modify the interstellar interaction as a whole. The next quantum leap enabled by IMAP will open new windows on the frontier of Heliophysics and probe the acceleration of suprathermal and higher energy particles at a time when the space environment is rapidly evolving. IMAP ultimately connects the acceleration processes observed directly at 1 AU with unprecedented sensitivity and temporal resolution with the global structure of our heliosphere. The remarkable synergy between IMAP, Voyager 1 and Voyager 2 will remain for at least the next decade as Voyager 1 pushes further into the interstellar domain and Voyager 2 moves through the heliosheath. IMAP, like ACE before it, will be a keystone of the Heliophysics System Observatory by providing comprehensive energetic particle, pickup ion, suprathermal ion, neutral atom, solar wind, solar wind heavy ion, and magnetic field observations to diagnose

  11. Low-energy (< 200 eV) electron acceleration by ULF waves in the plasmaspheric boundary layer: Van Allen Probes observation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ren, Jie; Zong, Q. G.; Miyoshi, Y.

    Here, we report observational evidence of cold plamsmaspheric electron (< 200 eV) acceleration by ultra-low-frequency (ULF) waves in the plasmaspheric boundary layer on 10 September 2015. Strongly enhanced cold electron fluxes in the energy spectrogram were observed along with second harmonic mode waves with a period of about 1 minute which lasted several hours during two consecutive Van Allen Probe B orbits. Cold electron (<200 eV) and energetic proton (10-20 keV) bi-directional pitch angle signatures observed during the event are suggestive of the drift-bounce resonance mechanism. The correlation between enhanced energy fluxes and ULF waves leads to the conclusions thatmore » plasmaspheric dynamics is strongly affected by ULF waves. Van Allen Probe A and B, GOES 13, GOES 15 and MMS 1 observations suggest ULF waves in the event were strongest on the dusk-side magnetosphere. Measurements from MMS 1 contain no evidence of an external wave source during the period when ULF waves and injected energetic protons with a bump-on-tail distribution were detected by Van Allen Probe B. This suggests that the observed ULF waves were probably excited by a localized drift-bounce resonant instability, with the free energy supplied by substorm-injected energetic protons. The observations by Van Allen Probe B suggest that energy transfer between particle species in different energy ranges can take place through the action of ULF waves, demonstrating the important role of these waves in the dynamical processes of the inner magnetosphere.« less

  12. Low-energy (< 200 eV) electron acceleration by ULF waves in the plasmaspheric boundary layer: Van Allen Probes observation

    DOE PAGES

    Ren, Jie; Zong, Q. G.; Miyoshi, Y.; ...

    2017-08-30

    Here, we report observational evidence of cold plamsmaspheric electron (< 200 eV) acceleration by ultra-low-frequency (ULF) waves in the plasmaspheric boundary layer on 10 September 2015. Strongly enhanced cold electron fluxes in the energy spectrogram were observed along with second harmonic mode waves with a period of about 1 minute which lasted several hours during two consecutive Van Allen Probe B orbits. Cold electron (<200 eV) and energetic proton (10-20 keV) bi-directional pitch angle signatures observed during the event are suggestive of the drift-bounce resonance mechanism. The correlation between enhanced energy fluxes and ULF waves leads to the conclusions thatmore » plasmaspheric dynamics is strongly affected by ULF waves. Van Allen Probe A and B, GOES 13, GOES 15 and MMS 1 observations suggest ULF waves in the event were strongest on the dusk-side magnetosphere. Measurements from MMS 1 contain no evidence of an external wave source during the period when ULF waves and injected energetic protons with a bump-on-tail distribution were detected by Van Allen Probe B. This suggests that the observed ULF waves were probably excited by a localized drift-bounce resonant instability, with the free energy supplied by substorm-injected energetic protons. The observations by Van Allen Probe B suggest that energy transfer between particle species in different energy ranges can take place through the action of ULF waves, demonstrating the important role of these waves in the dynamical processes of the inner magnetosphere.« less

  13. Towards pump-probe experiments of defect dynamics with short ion beam pulses

    NASA Astrophysics Data System (ADS)

    Schenkel, T.; Lidia, S. M.; Weis, C. D.; Waldron, W. L.; Schwartz, J.; Minor, A. M.; Hosemann, P.; Kwan, J. W.

    2013-11-01

    A novel, induction type linear accelerator, the Neutralized Drift Compression eXperiment (NDCX-II), is currently being commissioned at Berkeley Lab. This accelerator is designed to deliver intense (up to 3 × 1011 ions/pulse), 0.6 to ∼600 ns duration pulses of 0.05-1.2 MeV lithium ions at a rate of about 2 pulses per minute onto 1-10 mm scale target areas. When focused to mm-diameter spots, the beam is predicted to volumetrically heat micrometer thick foils to temperatures of ∼30,000 °K. At lower beam power densities, the short excitation pulse with tunable intensity and time profile enables pump-probe type studies of defect dynamics in a broad range of materials. We briefly describe the accelerator concept and design, present results from beam pulse shaping experiments and discuss examples of pump-probe type studies of defect dynamics following irradiation of materials with intense, short ion beam pulses from NDCX-II.

  14. Cosmological consistency tests of gravity theory and cosmic acceleration

    NASA Astrophysics Data System (ADS)

    Ishak-Boushaki, Mustapha B.

    2017-01-01

    Testing general relativity at cosmological scales and probing the cause of cosmic acceleration are among the important objectives targeted by incoming and future astronomical surveys and experiments. I present our recent results on consistency tests that can provide insights about the underlying gravity theory and cosmic acceleration using cosmological data sets. We use statistical measures, the rate of cosmic expansion, the growth rate of large scale structure, and the physical consistency of these probes with one another.

  15. Probing SEP Acceleration Processes With Near-relativistic Electrons

    NASA Astrophysics Data System (ADS)

    Haggerty, Dennis K.; Roelof, Edmond C.

    2009-11-01

    Processes in the solar corona are prodigious accelerators of near-relativistic electrons. Only a small fraction of these electrons escape the low corona, yet they are by far the most abundant species observed in Solar Energetic Particle events. These beam-like energetic electron events are sometimes time-associated with coronal mass ejections from the western solar hemisphere. However, a significant number of events are observed without any apparent association with a transient event. The relationship between solar energetic particle events, coronal mass ejections, and near-relativistic electron events are better ordered when we classify the intensity time profiles during the duration of the beam-like anisotropies into three broad categories: 1) Spikes (rapid and equal rise and decay) 2) Pulses (rapid rise, slower decay) and 3) Ramps (rapid rise followed by a plateau). We report on the results of a study that is based on our catalog (covering nearly the complete Solar Cycle 23) of 216 near-relativistic electron events and their association with: solar electromagnetic emissions, shocks driven by coronal mass ejections, models of the coronal magnetic fields and energetic protons. We conclude that electron events with time-intensity profiles of Spikes and Pulses are associated with explosive events in the low corona while events with time-intensity profiles of Ramps are associated with the injection/acceleration process of the CME driven shock.

  16. Van Allen Probes observations of structured whistler mode activity and coincident electron Landau acceleration inside a remnant plasmaspheric plume

    NASA Astrophysics Data System (ADS)

    Woodroffe, J. R.; Jordanova, V. K.; Funsten, H. O.; Streltsov, A. V.; Bengtson, M. T.; Kletzing, C. A.; Wygant, J. R.; Thaller, S. A.; Breneman, A. W.

    2017-03-01

    We present observations from the Van Allen Probes spacecraft that identify a region of intense whistler mode activity within a large density enhancement outside of the plasmasphere. We speculate that this density enhancement is part of a remnant plasmaspheric plume, with the observed wave being driven by a weakly anisotropic electron injection that drifted into the plume and became nonlinearly unstable to whistler emission. Particle measurements indicate that a significant fraction of thermal (<100 eV) electrons within the plume were subject to Landau acceleration by these waves, an effect that is naturally explained by whistler emission within a gradient and high-density ducting inside a density enhancement.

  17. GAMMA-RAY AND HARD X-RAY EMISSION FROM PULSAR-AIDED SUPERNOVAE AS A PROBE OF PARTICLE ACCELERATION IN EMBRYONIC PULSAR WIND NEBULAE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Murase, Kohta; Kashiyama, Kazumi; Kiuchi, Kenta

    2015-05-20

    It has been suggested that some classes of luminous supernovae (SNe) and gamma-ray bursts (GRBs) are driven by newborn magnetars. Fast-rotating proto-neutron stars have also been of interest as potential sources of gravitational waves (GWs). We show that for a range of rotation periods and magnetic fields, hard X-rays and GeV gamma rays provide us with a promising probe of pulsar-aided SNe. It is observationally known that young pulsar wind nebulae (PWNe) in the Milky Way are very efficient lepton accelerators. We argue that, if embryonic PWNe satisfy similar conditions at early stages of SNe (in ∼1–10 months after themore » explosion), external inverse-Compton emission via upscatterings of SN photons is naturally expected in the GeV range as well as broadband synchrotron emission. To fully take into account the Klein–Nishina effect and two-photon annihilation process that are important at early times, we perform detailed calculations including electromagnetic cascades. Our results suggest that hard X-ray telescopes such as NuSTAR can observe such early PWN emission by follow-up observations in months to years. GeV gamma-rays may also be detected by Fermi for nearby SNe, which serve as counterparts of these GW sources. Detecting the signals will give us an interesting probe of particle acceleration at early times of PWNe, as well as clues to driving mechanisms of luminous SNe and GRBs. Since the Bethe–Heitler cross section is lower than the Thomson cross section, gamma rays would allow us to study subphotospheric dissipation. We encourage searches for high-energy emission from nearby SNe, especially SNe Ibc including super-luminous objects.« less

  18. An Experimental Study of a Low-Jitter Pulsed Electromagnetic Plasma Accelerator

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Lee, Michael; Eskridge, Richard; Smith, James; Martin, Adam; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    An experimental plasma accelerator for a variety of applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a pulsed plasma thruster and has been tested experimentally and plasma jet velocities of approximately 50 kilometers per second have been obtained. The plasma jet structure has been photographed with 10 ns exposure times to reveal a stable and repeatable plasma structure. Data for velocity profile information has been obtained using light pipes embedded in the gun walls to record the plasma transit at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter has been characterized and future work for second generation "ultra-low jitter" gun development is identified.

  19. Aligning the magnetic field of a linear induction accelerator with a low-energy electron beam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clark, J.C.; Deadrick, F.J.; Kallman, J.S.

    1989-03-10

    The Experimental Test Accelerator II (ETA-II) linear induction accelerator at Lawrence Livermore National Laboratory uses a solenoid magnet in each acceleration cell to focus and transport an electron beam over the length of the accelerator. To control growth of the corkscrew mode the magnetic field must be precisely aligned over the full length of the accelerate. Concentric with each solenoid magnet is sine/cosmic-wound correction coil to steer the beam and correct field errors. A low-energy electron probe traces the central flux line through the accelerator referenced to a mechanical axis that is defined by a copropagating laser beam. Correction coilsmore » are activated to force the central flux line to cross the mechanical axis at the end of each acceleration cell. The ratios of correction coil currents determined by the low-energy electron probe are then kept fixed to correct for field errors during normal operation with an accelerated beam. We describe the construction of the low-energy electron probe and report the results of experiments we conducted to measure magnetic alignment with and without the correction coils activated. 5 refs., 3 figs.« less

  20. Solar Probe Plus: A NASA Mission to Touch the Sun

    NASA Astrophysics Data System (ADS)

    Fox, N. J.; Bale, S. D.; Decker, R. B.; Howard, R.; Kasper, J. C.; McComas, D. J.; Szabo, A.; Velli, M. M.

    2013-12-01

    Solar Probe Plus (SPP), currently in Phase B, will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind is accelerated, solving two fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Solar Probe Plus mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. The SPP mission will achieve this by identifying and quantifying the basic plasma physical processes at the heart of the Heliosphere. SPP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the SPP science objectives: 1) Trace the flow of energy that heats and accelerates the solar corona and solar wind; 2) Determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind; and 3) Explore mechanisms that accelerate and transport energetic particles. In this poster, we present Solar Probe Plus and examine how the mission will address the science questions that have remained unanswered for over 5 decades.

  1. Solar Probe Plus: A NASA Mission to Touch the Sun

    NASA Astrophysics Data System (ADS)

    Fox, N. J.; Velli, M. M. C.; Kasper, J. C.; McComas, D. J.; Howard, R.; Bale, S. D.; Decker, R. B.

    2014-12-01

    Solar Probe Plus (SPP), currently in Phase C, will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind and energetic particles are accelerated, solving fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Solar Probe Plus mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. The SPP mission will achieve this by identifying and quantifying the basic plasma physical processes at the heart of the Heliosphere. SPP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the SPP science objectives: 1) Trace the flow of energy that heats and accelerates the solar corona and solar wind; 2) Determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind; and 3) Explore mechanisms that accelerate and transport energetic particles. In this presentation, we present Solar Probe Plus and examine how the mission will address the science questions that have remained unanswered for over 5 decades.

  2. Preliminary tests of the electrostatic plasma accelerator

    NASA Technical Reports Server (NTRS)

    Aston, G.; Acker, T.

    1990-01-01

    This report describes the results of a program to verify an electrostatic plasma acceleration concept and to identify those parameters most important in optimizing an Electrostatic Plasma Accelerator (EPA) thruster based upon this thrust mechanism. Preliminary performance measurements of thrust, specific impulse and efficiency were obtained using a unique plasma exhaust momentum probe. Reliable EPA thruster operation was achieved using one power supply.

  3. Interpretation of plasma impurity deposition probes. Analytic approximation

    NASA Astrophysics Data System (ADS)

    Stangeby, P. C.

    1987-10-01

    Insertion of a probe into the plasma induces a high speed flow of the hydrogenic plasma to the probe which, by friction, accelerates the impurity ions to velocities approaching the hydrogenic ion acoustic speed, i.e., higher than the impurity ion thermal speed. A simple analytic theory based on this effect provides a relation between impurity fluxes to the probe Γimp and the undisturbed impurity ion density nimp, with the hydrogenic temperature and density as input parameters. Probe size also influences the collection process and large probes are found to attract a higher flux density than small probes in the same plasma. The quantity actually measured, cimp, the impurity atom surface density (m-2) net-deposited on the probe, is related to Γimp and thus to nimp by taking into account the partial removal of deposited material caused by sputtering and the redeposition process.

  4. Arc-driven rail accelerator research

    NASA Technical Reports Server (NTRS)

    Ray, Pradosh K.

    1987-01-01

    Arc-driven rail accelerator research is analyzed by considering wall ablation and viscous drag in the plasma. Plasma characteristics are evaluated through a simple fluid-mechanical analysis considering only wall ablation. By equating the energy dissipated in the plasma with the radiation heat loss, the average properties of the plasma are determined as a function of time and rate of ablation. Locations of two simultaneously accelerating arcs were determined by optical and magnetic probes and fron streak camera photographs. All three measurements provide consistent results.

  5. Electrokinetic acceleration of DNA hybridization in microsystems.

    PubMed

    Lei, Kin Fong; Wang, Yun-Hsiang; Chen, Huai-Yi; Sun, Jia-Hong; Cheng, Ji-Yen

    2015-06-01

    In this work, electrokinetic acceleration of DNA hybridization was investigated by different combinations of frequencies and amplitudes of actuating electric signals. Because the frequencies from low to high can induce different kinds of electrokinetic forces, i.e., electroosmotic to electrothermal forces, this work provides an in-depth investigation of electrokinetic enhanced hybridization. Concentric circular Cr/Au microelectrodes of 350 µm in diameter were fabricated on a glass substrate and probe DNA was immobilized on the electrode surface. Target DNA labeled with fluorescent dyes suspending in solution was then applied to the electrode. Different electrokinetic forces were induced by the application of different electric signals to the circular microelectrodes. Local microfluidic vortexes were generated to increase the collision efficiency between the target DNA suspending in solution and probe DNA immobilized on the electrode surface. DNA hybridization on the electrode surface could be accelerated by the electrokinetic forces. The level of hybridization was represented by the fluorescent signal intensity ratio. Results revealed that such 5-min dynamic hybridization increased 4.5 fold of signal intensity ratio as compared to a 1-h static hybridization. Moreover, dynamic hybridization was found to have better differentiation ability between specific and non-specific target DNA. This study provides a strategy to accelerate DNA hybridization in microsystems. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. SNAP: Small Next-generation Atmospheric Probe Concept

    NASA Astrophysics Data System (ADS)

    Sayanagi, K. M.; Dillman, R. A.; Atkinson, D. H.; Li, J.; Saikia, S.; Simon, A. A.; Spilker, T. R.; Wong, M. H.; Hope, D.

    2017-12-01

    We present a concept for a small, atmospheric probe that could be flexibly added to future missions that orbit or fly-by a giant planet as a secondary payload, which we call the Small Next-generation Atmospheric Probe (SNAP). SNAP's main scientific objectives are to determine the vertical distribution of clouds and cloud-forming chemical species, thermal stratification, and wind speed as a function of depth. As a case study, we present the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flagship mission; in combination with the mission's main probe, SNAP would perform atmospheric in-situ measurements at a second location, and thus enable and enhance the scientific objectives recommended by the 2013 Planetary Science Decadal Survey and the 2014 NASA Science Plan to determine atmospheric spatial variabilities. We envision that the science objectives can be achieved with a 30-kg entry probe 0.5m in diameter (less than half the size of the Galileo probe) that reaches 5-bar pressure-altitude and returns data to Earth via the carrier spacecraft. As the baseline instruments, the probe will carry an Atmospheric Structure Instrument (ASI) that measures the temperature, pressure and acceleration, a carbon nanotube-based NanoChem atmospheric composition sensor, and an Ultra-Stable Oscillator (USO) to conduct a Doppler Wind Experiment (DWE). We also catalog promising technologies currently under development that will strengthen small atmospheric entry probe missions in the future. While SNAP is applicable to multiple planets, we examine the feasibility, benefits and impacts of adding SNAP to the Uranus Orbiter and Probe flagship mission. Our project is supported by NASA PSDS3 grant NNX17AK31G.

  7. Electron Injections: A Study of Electron Acceleration by Multiple Dipolarizing Flux Bundles Using an Analytical Model

    NASA Astrophysics Data System (ADS)

    Gabrielse, C.; Angelopoulos, V.; Artemyev, A.; Runov, A.; Harris, C.

    2016-12-01

    We study energetic electron injections using an analytical model that self-consistently describes electric and magnetic field perturbations of transient, localized dipolarizing flux bundles (DFBs). Previous studies using THEMIS, Van Allen Probes, and the Magnetospheric Multiscale Mission have shown that injections can occur on short (minutes) or long (10s of minutes) timescales. These studies suggest that the short timescale injections correspond to a single DFB, whereas long timescale injections are likely caused by an aggregate of multiple DFBs, each incrementally heating the particle population. We therefore model the effects of multiple DFBs on the electron population using multi-spacecraft observations of the fields and particle fluxes to constrain the model parameters. The analytical model is the first of its kind to model multiple dipolarization fronts in order to better understand the transport and acceleration process throughout the plasma sheet. It can reproduce most injection signatures at multiple locations simultaneously, reaffirming earlier findings that multiple earthward-traveling DFBs can both transport and accelerate electrons to suprathermal energies, and can thus be considered the injections' primary driver.

  8. Flight calibration of compensated and uncompensated pitot-static airspeed probes and application of the probes to supersonic cruise vehicles

    NASA Technical Reports Server (NTRS)

    Webb, L. D.; Washington, H. P.

    1972-01-01

    Static pressure position error calibrations for a compensated and an uncompensated XB-70 nose boom pitot static probe were obtained in flight. The methods (Pacer, acceleration-deceleration, and total temperature) used to obtain the position errors over a Mach number range from 0.5 to 3.0 and an altitude range from 25,000 feet to 70,000 feet are discussed. The error calibrations are compared with the position error determined from wind tunnel tests, theoretical analysis, and a standard NACA pitot static probe. Factors which influence position errors, such as angle of attack, Reynolds number, probe tip geometry, static orifice location, and probe shape, are discussed. Also included are examples showing how the uncertainties caused by position errors can affect the inlet controls and vertical altitude separation of a supersonic transport.

  9. Solar Probe Plus: A mission to touch the sun

    NASA Astrophysics Data System (ADS)

    Kinnison, J.; Lockwood, M. K.; Fox, N.; Conde, R.; Driesman, A.

    Solar Probe Plus (SPP), currently in Phase B, will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind is accelerated, solving two fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. SPP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the SPP science objectives: 1) determine the structure and dynamics of the magnetic fields at the sources of the fast and slow solar wind, 2) trace the flow of energy that heats the corona and accelerates the solar wind. and 3) determine what mechanisms accelerate and transport energetic particles. In this paper, we present the Solar Probe Plus mission along with a brief comparison with some previous concepts for such a mission, and discuss the trade studies that led to the SPP implementation. We present a summary of the challenges associated with operation in the solar encounter environment and discuss the technology development and engineering trade studies to compose a mission that will not only survive this environment, but will provide the data needed to answer the science questions that have remained unanswered to date.

  10. Shock-wave proton acceleration from a hydrogen gas jet

    NASA Astrophysics Data System (ADS)

    Cook, Nathan; Pogorelsky, Igor; Polyanskiy, Mikhail; Babzien, Marcus; Tresca, Olivier; Maharjan, Chakra; Shkolnikov, Peter; Yakimenko, Vitaly

    2013-04-01

    Typical laser acceleration experiments probe the interaction of intense linearly-polarized solid state laser pulses with dense metal targets. This interaction generates strong electric fields via Transverse Normal Sheath Acceleration and can accelerate protons to high peak energies but with a large thermal spectrum. Recently, the advancement of high pressure amplified CO2 laser technology has allowed for the creation of intense (10^16 Wcm^2) pulses at λ˜10 μm. These pulses may interact with reproducible, high rep. rate gas jet targets and still produce plasmas of critical density (nc˜10^19 cm-3), leading to the transference of laser energy via radiation pressure. This acceleration mode has the advantage of producing narrow energy spectra while scaling well with pulse intensity. We observe the interaction of an intense CO2 laser pulse with an overdense hydrogen gas jet. Using two pulse optical probing in conjunction with interferometry, we are able to obtain density profiles of the plasma. Proton energy spectra are obtained using a magnetic spectrometer and scintillating screen.

  11. Weak lensing probe of cubic Galileon model

    NASA Astrophysics Data System (ADS)

    Dinda, Bikash R.

    2018-06-01

    The cubic Galileon model containing the lowest non-trivial order action of the full Galileon action can produce the stable late-time cosmic acceleration. This model can have a significant role in the growth of structures. The signatures of the cubic Galileon model in the structure formation can be probed by the weak lensing statistics. Weak lensing convergence statistics is one of the strongest probes to the structure formation and hence it can probe the dark energy or modified theories of gravity models. In this work, we investigate the detectability of the cubic Galileon model from the ΛCDM model or from the canonical quintessence model through the convergence power spectrum and bi-spectrum.

  12. Thomson-backscattered x rays from laser-accelerated electrons.

    PubMed

    Schwoerer, H; Liesfeld, B; Schlenvoigt, H-P; Amthor, K-U; Sauerbrey, R

    2006-01-13

    We present the first observation of Thomson-backscattered light from laser-accelerated electrons. In a compact, all-optical setup, the "photon collider," a high-intensity laser pulse is focused into a pulsed He gas jet and accelerates electrons to relativistic energies. A counterpropagating laser probe pulse is scattered from these high-energy electrons, and the backscattered x-ray photons are spectrally analyzed. This experiment demonstrates a novel source of directed ultrashort x-ray pulses and additionally allows for time-resolved spectroscopy of the laser acceleration of electrons.

  13. Amps particle accelerator definition study

    NASA Technical Reports Server (NTRS)

    Sellen, J. M., Jr.

    1975-01-01

    The Particle Accelerator System of the AMPS (Atmospheric, Magnetospheric, and Plasmas in Space) payload is a series of charged particle accelerators to be flown with the Space Transportation System Shuttle on Spacelab missions. In the configuration presented, the total particle accelerator system consists of an energetic electron beam, an energetic ion accelerator, and both low voltage and high voltage plasma acceleration devices. The Orbiter is illustrated with such a particle accelerator system.

  14. Outer planet entry probe system study. Volume 2: Supporting technical studies

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The environment, science investigations, and general mission analysis considerations are given first. These data are followed by discussions of the studies pertaining to the planets Jupiter, Saturn, Uranus, and Neptune. Except for Neptune, each planet discussion is divided into two parts: (1) parametric activities and (2) probe definition for that planet, or the application of a given probe for that planet. The Neptune discussion is limited to parametrics in the area of science and mission analysis. Each of the probe system definitions consists of system and subsystem details including telecommunications, data handling, power pyrotechnics, attitude control, structures, propulsion, thermal control, and probe to spacecraft integration. The first configuration is discussed in detail and the subsequent configuration discussions are limited to the differences. Finally, the hardware availability to support a probe system and commonality of science, missions, and subsystems for use at the various planets are considered.

  15. Energetics of small electron acceleration episodes in the solar corona from radio noise storm observations

    NASA Astrophysics Data System (ADS)

    James, Tomin; Subramanian, Prasad

    2018-05-01

    Observations of radio noise storms can act as sensitive probes of nonthermal electrons produced in small acceleration events in the solar corona. We use data from noise storm episodes observed jointly by the Giant Metrewave Radio Telescope (GMRT) and the Nancay Radioheliograph (NRH) to study characteristics of the nonthermal electrons involved in the emission. We find that the electrons carry 1021 to 1024 erg/s, and that the energy contained in the electrons producing a representative noise storm burst ranges from 1020 to 1023 ergs. These results are a direct probe of the energetics involved in ubiquitous, small-scale electron acceleration episodes in the corona, and could be relevant to a nanoflare-like scenario for coronal heating.

  16. Dark energy two decades after: observables, probes, consistency tests.

    PubMed

    Huterer, Dragan; Shafer, Daniel L

    2018-01-01

    The discovery of the accelerating universe in the late 1990s was a watershed moment in modern cosmology, as it indicated the presence of a fundamentally new, dominant contribution to the energy budget of the universe. Evidence for dark energy, the new component that causes the acceleration, has since become extremely strong, owing to an impressive variety of increasingly precise measurements of the expansion history and the growth of structure in the universe. Still, one of the central challenges of modern cosmology is to shed light on the physical mechanism behind the accelerating universe. In this review, we briefly summarize the developments that led to the discovery of dark energy. Next, we discuss the parametric descriptions of dark energy and the cosmological tests that allow us to better understand its nature. We then review the cosmological probes of dark energy. For each probe, we briefly discuss the physics behind it and its prospects for measuring dark energy properties. We end with a summary of the current status of dark energy research.

  17. Parker Solar Probe: A NASA Mission to Touch the Sun: Mission Status Update

    NASA Astrophysics Data System (ADS)

    Fox, N. J.

    2017-12-01

    The newly renamed, Parker Solar Probe (PSP) mission will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind and energetic particles are accelerated, solving fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Parker Solar Probe mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. PSP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the science objectives. In this presentation, we provide an update on the progress of the Parker Solar Probe mission as we prepare for the July 2018 launch.

  18. Solar Probe Plus: A NASA Mission to Touch the SunMission Status Update

    NASA Astrophysics Data System (ADS)

    Fox, N. J.

    2016-12-01

    Solar Probe Plus (SPP), currently in Phase D, will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind and energetic particles are accelerated, solving fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Solar Probe Plus mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. SPP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the SPP science objectives. In this presentation, we provide an update on the progress of the Solar Probe Plus mission as we prepare for the July 2018 launch.

  19. Study of alternative probe technologies

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A number of implied technologies for a deep probe mission was examined; i.e., one that would provide the capability to scientifically examine planetary atmospheres at the 1000 bar level. Conditions imposed by current Jupiter, Saturn, and Uranus atmospheric models were considered. The major thrust of the measurements was to determine lower atmosphere composition, even to trace constituents of one part per billion. Two types of instruments having the necessary accuracy to meet the science objectives were considered and integrated into a deep probe configuration. One deep probe option that resulted was identified as a Minimum Technology Development approach. The significant feature of this option is that only three technology developments are required to enable the mission, i.e., (1) science instrument development, (2) advanced data processing, and (3) external high pressure/thermal insulation. It is concluded that a probe designed for a Jupiter mission could, with minor changes, be used for a Saturn or Uranus mission.

  20. Accelerated Photobleaching of a Cyanine Dye in the Presence of a Ternary Target DNA, PNA Probe, Dye Catalytic Complex: A Molecular Diagnostic

    PubMed Central

    Wang, M.; Holmes-Davis, R.; Rafinski, Z.; Jedrzejewska, B.; Choi, K. Y.; Zwick, M.; Bupp, C.; Izmailov, A.; Paczkowski, J.; Warner, B.; Koshinsky, H.

    2009-01-01

    In many settings, molecular testing is needed but unavailable due to complexity and cost. Simple, rapid, and specific DNA detection technologies would provide important alternatives to existing detection methods. Here we report a novel, rapid nucleic acid detection method based on the accelerated photobleaching of the light-sensitive cyanine dye, 3,3′-diethylthiacarbocyanine iodide (DiSC2(3) I−), in the presence of a target genomic DNA and a complementary peptide nucleic acid (PNA) probe. On the basis of the UV–vis, circular dichroism, and fluorescence spectra of DiSC2(3) with PNA–DNA oligomer duplexes and on characterization of a product of photolysis of DiSC2(3) I−, a possible reaction mechanism is proposed. We propose that (1) a novel complex forms between dye, PNA, and DNA, (2) this complex functions as a photosensitizer producing 1O2, and (3) the 1O2 produced promotes photobleaching of dye molecules in the mixture. Similar cyanine dyes (DiSC3(3), DiSC4(3), DiSC5(3), and DiSCpy(3)) interact with preformed PNA–DNA oligomer duplexes but do not demonstrate an equivalent accelerated photobleaching effect in the presence of PNA and target genomic DNA. The feasibility of developing molecular diagnostic assays based on the accelerated photobleaching (the smartDNA assay) that results from the novel complex formed between DiSC2(3) and PNA–DNA is under way. PMID:19231844

  1. Scale-by-scale contributions to Lagrangian particle acceleration

    NASA Astrophysics Data System (ADS)

    Lalescu, Cristian C.; Wilczek, Michael

    2017-11-01

    Fluctuations on a wide range of scales in both space and time are characteristic of turbulence. Lagrangian particles, advected by the flow, probe these fluctuations along their trajectories. In an effort to isolate the influence of the different scales on Lagrangian statistics, we employ direct numerical simulations (DNS) combined with a filtering approach. Specifically, we study the acceleration statistics of tracers advected in filtered fields to characterize the smallest temporal scales of the flow. Emphasis is put on the acceleration variance as a function of filter scale, along with the scaling properties of the relevant terms of the Navier-Stokes equations. We furthermore discuss scaling ranges for higher-order moments of the tracer acceleration, as well as the influence of the choice of filter on the results. Starting from the Lagrangian tracer acceleration as the short time limit of the Lagrangian velocity increment, we also quantify the influence of filtering on Lagrangian intermittency. Our work complements existing experimental results on intermittency and accelerations of finite-sized, neutrally-buoyant particles: for the passive tracers used in our DNS, feedback effects are neglected such that the spatial averaging effect is cleanly isolated.

  2. Pump-probe studies of radiation induced defects and formation of warm dense matter with pulsed ion beams

    NASA Astrophysics Data System (ADS)

    Schenkel, T.; Persaud, A.; Gua, H.; Seidl, P. A.; Waldron, W. L.; Gilson, E. P.; Kaganovich, I. D.; Davidson, R. C.; Friedman, A.; Barnard, J. J.; Minior, A. M.

    2014-10-01

    We report results from the 2nd generation Neutralized Drift Compression Experiment at Berkeley Lab. NDCX-II is a pulsed, linear induction accelerator designed to drive thin foils to warm dense matter (WDM) states with peak temperatures of ~ 1 eV using intense, short pulses of 1.2 MeV lithium ions. Tunability of the ion beam enables pump-probe studies of radiation effects in solids as a function of excitation density, from isolated collision cascades to the onset of phase-transitions and WDM. Ion channeling is an in situ diagnostic of damage evolution during ion pulses with a sensitivity of <0.1% displacements per atom. We will report results from damage evolution studies in thin silicon crystals with Li + and K + beams. Detection of channeled ions tracks lattice disorder evolution with a resolution of ~ 1 ns using fast current measurements. We will discuss pump-probe experiments with pulsed ion beams and the development of diagnostics for WDM and multi-scale (ms to fs) access to the materials physics of collision cascades e.g. in fusion reactor materials. Work performed under auspices of the US DOE under Contract No. DE-AC02-05CH11231.

  3. The effect of blood acceleration on the ultrasound power Doppler spectrum

    NASA Astrophysics Data System (ADS)

    Matchenko, O. S.; Barannik, E. A.

    2017-09-01

    The purpose of the present work was to study the influence of blood acceleration and time window length on the power Doppler spectrum for Gaussian ultrasound beams. The work has been carried out on the basis of continuum model of the ultrasound scattering from inhomogeneities in fluid flow. Correlation function of fluctuations has been considered for uniformly accelerated scatterers, and the resulting power Doppler spectra have been calculated. It is shown that within the initial phase of systole uniformly accelerated slow blood flow in pulmonary artery and aorta tends to make the correlation function about 4.89 and 7.83 times wider, respectively, than the sensitivity function of typical probing system. Given peak flow velocities, the sensitivity function becomes, vice versa, about 4.34 and 3.84 times wider, respectively, then the correlation function. In these limiting cases, the resulting spectra can be considered as Gaussian. The optimal time window duration decreases with increasing acceleration of blood flow and equals to 11.62 and 7.54 ms for pulmonary artery and aorta, respectively. The width of the resulting power Doppler spectrum is shown to be defined mostly by the wave vector of the incident field, the duration of signal and the acceleration of scatterers in the case of low flow velocities. In the opposite case geometrical properties of probing field and the average velocity itself are more essential. In the sense of signal-noise ratio, the optimal duration of time window can be found. Abovementioned results may contribute to the improved techniques of Doppler ultrasound diagnostics of cardiovascular system.

  4. Review of Gravity Probe B

    NASA Technical Reports Server (NTRS)

    1995-01-01

    In response to a request by the NASA Administrator, the National Research Council (NRC) has conducted an accelerated scientific review of NASA's Gravity Probe B (GP-B) mission. The review was carried out by the Task Group on Gravity Probe B, under the auspices of the NRC's Space Studies Board and Board on Physics and Astronomy. The specific charge to the task group was to review the GP-B mission with respect to the following terms of reference: (1) scientific importance - including a current assessment of the value of the project in the context of recent progress in gravitational physics and relevant technology; (2) technical feasibility - the technical approach will be evaluated for likelihood of success, both in terms of achievement of flight mission objectives but also in terms of scientific conclusiveness of the various possible outcomes for the measurements to be made; and (3) competitive value - if possible, GP-B science will be assessed qualitatively against the objectives and accomplishments of one or more fundamental physics projects of similar cost (e.g., the Cosmic Background Explorer, COBE).

  5. Magnetohydrodynamic modeling of three Van Allen Probes storms in 2012 and 2013

    NASA Astrophysics Data System (ADS)

    Paral, J.; Hudson, M. K.; Kress, B. T.; Wiltberger, M. J.; Wygant, J. R.; Singer, H. J.

    2015-08-01

    Coronal mass ejection (CME)-shock compression of the dayside magnetopause has been observed to cause both prompt enhancement of radiation belt electron flux due to inward radial transport of electrons conserving their first adiabatic invariant and prompt losses which at times entirely eliminate the outer zone. Recent numerical studies suggest that enhanced ultra-low frequency (ULF) wave activity is necessary to explain electron losses deeper inside the magnetosphere than magnetopause incursion following CME-shock arrival. A combination of radial transport and magnetopause shadowing can account for losses observed at radial distances into L = 4.5, well within the computed magnetopause location. We compare ULF wave power from the Electric Field and Waves (EFW) electric field instrument on the Van Allen Probes for the 8 October 2013 storm with ULF wave power simulated using the Lyon-Fedder-Mobarry (LFM) global magnetohydrodynamic (MHD) magnetospheric simulation code coupled to the Rice Convection Model (RCM). Two other storms with strong magnetopause compression, 8-9 October 2012 and 17-18 March 2013, are also examined. We show that the global MHD model captures the azimuthal magnetosonic impulse propagation speed and amplitude observed by the Van Allen Probes which is responsible for prompt acceleration at MeV energies reported for the 8 October 2013 storm. The simulation also captures the ULF wave power in the azimuthal component of the electric field, responsible for acceleration and radial transport of electrons, at frequencies comparable to the electron drift period. This electric field impulse has been shown to explain observations in related studies (Foster et al., 2015) of electron acceleration and drift phase bunching by the Energetic Particle, Composition, and Thermal Plasma Suite (ECT) instrument on the Van Allen Probes.

  6. Sub-micron opto-chemical probes for studying living neurons

    NASA Astrophysics Data System (ADS)

    Hossein-Zadeh, M.; Delgado, J.; Schweizer, F.; Lieberman, R.

    2017-02-01

    We have fabricated sub-micron opto-chemical probes for pH, oxygen and calcium monitoring and demonstrated their application in intracellular and extracellular monitoring of neurons (cortical neuronal cultures and acute hippocampal slices). Using these probes, we have measured extracellular pH in the stratum radiatum of the CA1 region of mouse hippocampus upon stimulation of presynaptic Schaffer collateral axons. Synaptic transmission was monitored using standard electrophysiological techniques. We find that the local pH transiently changes in response to synaptic stimulation. In addition, the geometry of the functionalized region on the probe combined with high sensitivity imaging enables simultaneous monitoring of spatially adjacent but distinct compartments. As proof of concept we impaled cultured neurons with the probe measured calcium and pH inside as well as directly outside of neurons as we changed the pH and calcium concentration in the physiological solution in the perfusion chamber. As such these probes can be used to study the impact of the environment on both cellular and extra-cellular space. Additionally as the chemical properties of the surrounding medium can be controlled and monitored with high precision, these probes enable differential measurement of the target parameter referenced to a stable bath. This approach eliminates the uncertainties associated with non-chemical fluctuations in the fluorescent emission and result in a self-calibrated opto-chemical probe. We have also demonstrated multifunctional probes that are capable of measuring up to three parameters in the extracellular space in brain slices.

  7. Solar wind conditions leading to efficient radiation belt electron acceleration: A superposed epoch analysis

    DOE PAGES

    Li, W.; Thorne, R. M.; Bortnik, J.; ...

    2015-09-07

    In this study by determining preferential solar wind conditions leading to efficient radiation belt electron acceleration is crucial for predicting radiation belt electron dynamics. Using Van Allen Probes electron observations (>1 MeV) from 2012 to 2015, we identify a number of efficient and inefficient acceleration events separately to perform a superposed epoch analysis of the corresponding solar wind parameters and geomagnetic indices. By directly comparing efficient and inefficient acceleration events, we clearly show that prolonged southward Bz, high solar wind speed, and low dynamic pressure are critical for electron acceleration to >1 MeV energies in the heart of the outermore » radiation belt. We also evaluate chorus wave evolution using the superposed epoch analysis for the identified efficient and inefficient acceleration events and find that chorus wave intensity is much stronger and lasts longer during efficient electron acceleration events, supporting the scenario that chorus waves play a key role in MeV electron acceleration.« less

  8. Concrete probe-strength study : final report.

    DOT National Transportation Integrated Search

    1969-12-01

    The Windsor probe - test system was evaluated for determining compressive strength of concrete by comparing probe strengths against cylinder and core strengths from both laboratory and field-poured concrete. Advantages and disadvantages of this syste...

  9. Proton Probing using the T-Cubed Laser

    NASA Astrophysics Data System (ADS)

    Kordell, Peter; Campbell, Paul; Willingale, Louise; Maksimchuk, Anatoly; Krushelnick, Karl; Tubman, Eleanor; Woolsey, Nigel

    2015-11-01

    The University of Michigan's 20 TW, 400 fs pulse T-cubed laser can produce proton beams of up to 7.2 MeV through target normal sheeth acceleration. The proton flux at 4 MeV produces sufficient signal on Radiochromic Film for use as an ultrafast, electromagnetic field diagnostic. A two beam experiment has been set-up to enable co-timed, pump-probe relativistic intensity interactions. We present an evaluation of the flux, uniformity, energy and laminar flow of the proton probe for future use in imaging of a simple wire target interaction. This work was supported by the DOE (Grant No. DE-SC0012327).

  10. Overview of Accelerators with Potential Use in Homeland Security

    NASA Astrophysics Data System (ADS)

    Garnett, Robert W.

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also be discussed.

  11. Study of new systems concepts for a Titan atmospheric probe

    NASA Technical Reports Server (NTRS)

    Bernard, Doug; Citron, Todd; Drean, Robert; Lewis, Scott; Lo, Martin; Mccarthy, John; Soderblom, Robert; Steffy, Dave; Vargas, Tina; Wolff, Marty

    1986-01-01

    Results of a systems concepts study for a Titan Probe were examined. The key tradeoffs performed are described in detail. Mass breakdown of each Probe subsystem or major element were given. The mission analysis performed to determine compliance with the high altitude sampling and descent time requirements are described. The baseline Descent Module design was derived. The element of the Probe System left on the Carrier after separation were described.

  12. Experiments with probe masses

    PubMed Central

    Braginsky, V. B.

    2007-01-01

    It is reasonable to regard the experiments performed by C. Coulomb and H. Cavendish in the end of the 18th century as the beginning of laboratory experimental physics. These outstanding scientists have measured forces (accelerations) produced by electric charges and by gravitational “charges” on probe masses that were attached to torque balance. Among the variety of different research programs and projects existing today, experiments with probe masses are still playing an important role. In this short review, the achieved and planned sensitivities of very challenging LIGO (Laser Interferometer Gravitational wave Observatory) and LISA (Laser Interferometer Space Antennae) projects are described, and a list of nonsolved problems is discussed as well. The role of quantum fluctuations in high precision measurements is also outlined. Apart from these main topics, the limitations of sensitivity caused by cosmic rays and the prospects of clock frequency stability are presented. PMID:17296944

  13. Laser-driven atomic-probe-beam diagnostics

    NASA Astrophysics Data System (ADS)

    Knyazev, B. A.; Greenly, J. B.; Hammer, D. A.

    2000-12-01

    A new laser-driven atomic-probe-beam diagnostic (LAD) is proposed for local, time-resolved measurements of electric field and ion dynamics in the accelerating gap of intense ion beam diodes. LAD adds new features to previous Stark-shift diagnostics which have been progressively developed in several laboratories, from passive observation of Stark effect on ion species or fast (charge-exchanged) neutrals present naturally in diodes, to active Stark atomic spectroscopy (ASAS) in which selected probe atoms were injected into the gap and excited to suitable states by resonant laser radiation. The LAD scheme is a further enhancement of ASAS in which the probe atoms are also used as a local (laser-ionized) ion source at an instant of time. Analysis of the ion energy and angular distribution after leaving the gap enables measurement, at the chosen ionization location in the gap, of both electrostatic potential and the development of ion divergence. Calculations show that all of these quantities can be measured with sub-mm and ns resolution. Using lithium or sodium probe atoms, fields from 0.1 to 10 MV/cm can be measured.

  14. Commissioning the GTA accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sander, O.R.; Atkins, W.H.; Bolme, G.O.

    1992-09-01

    The Ground Test Accelerator (GTA) is supported by the Strategic Defense command as part of their Neutral Particle Beam (NPB) program. Neutral particles have the advantage that in space they are unaffected by the earth`s magnetic field and travel in straight lines unless they enter the earth`s atmosphere and become charged by stripping. Heavy particles are difficult to stop and can probe the interior of space vehicles; hence, NPB can function as a discriminator between warheads and decoys. We are using GTA to resolve the physics and engineering issues related to accelerating, focusing, and steering a high-brightness, high-current H{sup -}more » beam and then neutralizing it. Our immediate goal is to produce a 24-MeV, 50mA device with a 2% duty factor.« less

  15. Commissioning the GTA accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sander, O.R.; Atkins, W.H.; Bolme, G.O.

    1992-01-01

    The Ground Test Accelerator (GTA) is supported by the Strategic Defense command as part of their Neutral Particle Beam (NPB) program. Neutral particles have the advantage that in space they are unaffected by the earth's magnetic field and travel in straight lines unless they enter the earth's atmosphere and become charged by stripping. Heavy particles are difficult to stop and can probe the interior of space vehicles; hence, NPB can function as a discriminator between warheads and decoys. We are using GTA to resolve the physics and engineering issues related to accelerating, focusing, and steering a high-brightness, high-current H{sup -}more » beam and then neutralizing it. Our immediate goal is to produce a 24-MeV, 50mA device with a 2% duty factor.« less

  16. Study of Strongly Coupled Systems via Probe Brane Constructions

    NASA Astrophysics Data System (ADS)

    Chang, Han-Chih

    In this thesis, we present our study towards better understanding of the strongly coupled systems with extra matter content in the fundamental representation of some prescribed global symmetry group in the quenched approximation, with the toolkit of holography via a probe brane construction. Specically, for the defect conformal systems, we unearth and quantify the phase trasition diagram, and novel supersymmetric vacua in the top-down model of the D3/D5 probe brane system. For further quantify various non-Fermi quantum liquid phases realized through the holographical probe brane construction, we then propose and verify the method to include the backreaction of entanglement entropy due to the probe branes at the leading order, which can potentially be used to detect topological phase transitions. We will recapitulate the main results of our works, in collaboration with Prof. Andreas Karch, published in the following journals: "Minimal Submanifolds asymptotic to AdS4 xS2 in AdS5xS5', JHEP, vol.1404, p.037, 2014; "The Novel Solutions of Finite-Density D3/D5 Probe Brane System and Their Implications for Stability'', JHEP, vol.1210, p.060, 2014; "Entanglement Entropy for Probe Branes'', JHEP, vol.1401, p.180, 2014.

  17. ESR/spin probe study of ice cream.

    PubMed

    Gillies, Duncan G; Greenley, Katherine R; Sutcliffe, Leslie H

    2006-07-12

    Spin probes based on the 1,1,3,3-tetramethylisoindolin-2-yl structure have been used, in conjunction with electron spin resonance spectroscopy (ESR), to study the physical changes occurring in ice cream during freezing and melting. The ESR measurements allowed the rotational correlation times, tau(B), of the spin probes to be determined. Two probes were used together in a given sample of ice cream, namely, 1,1,3,3-tetramethylisoindolin-2-yl (TMIO), which samples the fat phase, and the sodium salt of 1,1,3,3-tetramethylisoindolin-2-yloxyl-5-sulfonate (NaTMIOS), which samples the aqueous phase. Data from the TMIO probe showed that when ice cream is cooled, the fat phase is a mixture of solid and liquid fat until a temperature of approximately -60 degrees C is reached. The water-soluble probe NaTMIOS showed that the aqueous phase changes completely from liquid to solid within 1 degrees C of -18 degrees C. On cooling further to -24.7 degrees C and then allowing it to warm to +25.0 degrees C, the rotational correlation times of the NaTMIOS were slow to recover to their previous values. For the lipid phase, tau(B)(298) was found to be 65.7 +/- 2.0 ps and the corresponding activation enthalpy, DeltaH, was 32.5 +/- 0.9 kJ mol(-)(1): These values are typical of those expected to be found in the type of fat used to make ice cream. The water phase gave corresponding values of 32.2 +/- 0.5 ps and 24.5 +/- 0.4 kJ mol(-)(1) values, which are those expected for a sucrose concentration of 24%.

  18. Pioneer Jupiter orbiter probe mission 1980, probe description

    NASA Technical Reports Server (NTRS)

    Defrees, R. E.

    1974-01-01

    The adaptation of the Saturn-Uranus Atmospheric Entry Probe (SUAEP) to a Jupiter entry probe is summarized. This report is extracted from a comprehensive study of Jovian missions, atmospheric model definitions and probe subsystem alternatives.

  19. Study of a high-resolution PET system using a Silicon detector probe

    NASA Astrophysics Data System (ADS)

    Brzeziński, K.; Oliver, J. F.; Gillam, J.; Rafecas, M.

    2014-10-01

    A high-resolution silicon detector probe, in coincidence with a conventional PET scanner, is expected to provide images of higher quality than those achievable using the scanner alone. Spatial resolution should improve due to the finer pixelization of the probe detector, while increased sensitivity in the probe vicinity is expected to decrease noise. A PET-probe prototype is being developed utilizing this principle. The system includes a probe consisting of ten layers of silicon detectors, each a 80 × 52 array of 1 × 1 × 1 mm3 pixels, to be operated in coincidence with a modern clinical PET scanner. Detailed simulation studies of this system have been performed to assess the effect of the additional probe information on the quality of the reconstructed images. A grid of point sources was simulated to study the contribution of the probe to the system resolution at different locations over the field of view (FOV). A resolution phantom was used to demonstrate the effect on image resolution for two probe positions. A homogeneous source distribution with hot and cold regions was used to demonstrate that the localized improvement in resolution does not come at the expense of the overall quality of the image. Since the improvement is constrained to an area close to the probe, breast imaging is proposed as a potential application for the novel geometry. In this sense, a simplified breast phantom, adjacent to heart and torso compartments, was simulated and the effect of the probe on lesion detectability, through measurements of the local contrast recovery coefficient-to-noise ratio (CNR), was observed. The list-mode ML-EM algorithm was used for image reconstruction in all cases. As expected, the point spread function of the PET-probe system was found to be non-isotropic and vary with position, offering improvement in specific regions. Increase in resolution, of factors of up to 2, was observed in the region close to the probe. Images of the resolution phantom showed

  20. The challenge of turbulent acceleration of relativistic particles in the intra-cluster medium

    NASA Astrophysics Data System (ADS)

    Brunetti, Gianfranco

    2016-01-01

    Acceleration of cosmic-ray electrons (CRe) in the intra-cluster medium (ICM) is probed by radio observations that detect diffuse, megaparsec-scale, synchrotron sources in a fraction of galaxy clusters. Giant radio halos are the most spectacular manifestations of non-thermal activity in the ICM and are currently explained assuming that turbulence, driven during massive cluster-cluster mergers, reaccelerates CRe at several giga-electron volts. This scenario implies a hierarchy of complex mechanisms in the ICM that drain energy from large scales into electromagnetic fluctuations in the plasma and collisionless mechanisms of particle acceleration at much smaller scales. In this paper we focus on the physics of acceleration by compressible turbulence. The spectrum and damping mechanisms of the electromagnetic fluctuations, and the mean free path (mfp) of CRe, are the most relevant ingredients that determine the efficiency of acceleration. These ingredients in the ICM are, however, poorly known, and we show that calculations of turbulent acceleration are also sensitive to these uncertainties. On the other hand this fact implies that the non-thermal properties of galaxy clusters probe the complex microphysics and the weakly collisional nature of the ICM.

  1. A new approach to accelerated drug-excipient compatibility testing.

    PubMed

    Sims, Jonathan L; Carreira, Judith A; Carrier, Daniel J; Crabtree, Simon R; Easton, Lynne; Hancock, Stephen A; Simcox, Carol E

    2003-01-01

    The purpose of this study was to develop a method of qualitatively predicting the most likely degradants in a formulation or probing specific drug-excipient interactions in a significantly shorter time frame than the typical 1 month storage testing. In the example studied, accelerated storage testing of a solid dosage form at 50 degrees C, the drug substance SB-243213-A degraded via the formation of two oxidative impurities. These impurities reached a level of 1% PAR after 3 months. Various stressing methods were examined to try to recreate this degradation and in doing so provide a practical and reliable method capable of predicting drug-excipient interactions. The technique developed was able to mimic the 1-month's accelerated degradation in just 1 hr. The method was suitable for automated analysis, capable of multisample stressing, and ideal for use in drug-excipient compatibility screening.

  2. Overview of accelerators with potential use in homeland security

    DOE PAGES

    Garnett, Robert W.

    2015-06-18

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also bemore » discussed.« less

  3. Study of probe-sample distance for biomedical spectra measurement.

    PubMed

    Wang, Bowen; Fan, Shuzhen; Li, Lei; Wang, Cong

    2011-11-02

    Fiber-based optical spectroscopy has been widely used for biomedical applications. However, the effect of probe-sample distance on the collection efficiency has not been well investigated. In this paper, we presented a theoretical model to maximize the illumination and collection efficiency in designing fiber optic probes for biomedical spectra measurement. This model was in general applicable to probes with single or multiple fibers at an arbitrary incident angle. In order to demonstrate the theory, a fluorescence spectrometer was used to measure the fluorescence of human finger skin at various probe-sample distances. The fluorescence spectrum and the total fluorescence intensity were recorded. The theoretical results show that for single fiber probes, contact measurement always provides the best results. While for multi-fiber probes, there is an optimal probe distance. When a 400- μm excitation fiber is used to deliver the light to the skin and another six 400- μm fibers surrounding the excitation fiber are used to collect the fluorescence signal, the experimental results show that human finger skin has very strong fluorescence between 475 nm and 700 nm under 450 nm excitation. The fluorescence intensity is heavily dependent on the probe-sample distance and there is an optimal probe distance. We investigated a number of probe-sample configurations and found that contact measurement could be the primary choice for single-fiber probes, but was very inefficient for multi-fiber probes. There was an optimal probe-sample distance for multi-fiber probes. By carefully choosing the probe-sample distance, the collection efficiency could be enhanced by 5-10 times. Our experiments demonstrated that the experimental results of the probe-sample distance dependence of collection efficiency in multi-fiber probes were in general agreement with our theory.

  4. Naked singularities as particle accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patil, Mandar; Joshi, Pankaj S.

    We investigate here the particle acceleration by naked singularities to arbitrarily high center of mass energies. Recently it has been suggested that black holes could be used as particle accelerators to probe the Planck scale physics. We show that the naked singularities serve the same purpose and probably would do better than their black hole counterparts. We focus on the scenario of a self-similar gravitational collapse starting from a regular initial data, leading to the formation of a globally naked singularity. It is seen that when particles moving along timelike geodesics interact and collide near the Cauchy horizon, the energymore » of collision in the center of mass frame will be arbitrarily high, thus offering a window to Planck scale physics.« less

  5. Work on Planetary Atmospheres and Planetary Atmosphere Probes

    NASA Technical Reports Server (NTRS)

    Lester, Peter

    1999-01-01

    A summary final report of work accomplished is presented. Work was performed in the following areas: (1) Galileo Probe science analysis, (2) Galileo probe Atmosphere Structure Instrument, (3) Mars Pathfinder Atmosphere Structure/Meteorology instrument, (4) Mars Pathfinder data analysis, (5) Science Definition for future Mars missions, (6) Viking Lander data analysis, (7) winds in Mars atmosphere Venus atmospheric dynamics, (8) Pioneer Venus Probe data analysis, (9) Pioneer Venus anomaly analysis, (10) Discovery Venus Probe Titan probe instrument design, and (11) laboratory studies of Titan probe impact phenomena. The work has resulted in more than 10 articles published in archive journals, 2 encyclopedia articles, and many working papers. This final report is organized around the four planets on which there was activity, Jupiter, Mars, Venus, and Titan, with a closing section on Miscellaneous Activities. A major objective was to complete the fabrication, test, and evaluation of the atmosphere structure experiment on the Galileo probe, and to receive, analyze and interpret data received from the spacecraft. The instrument was launched on April 14, 1989. Calibration data were taken for all experiment sensors. The data were analyzed, fitted with algorithms, and summarized in a calibration report for use in analyzing and interpreting data returned from Jupiter's atmosphere. The sensors included were the primary science pressure, temperature and acceleration sensors, and the supporting engineering temperature sensors. Computer programs were written to decode the Experiment Data Record and convert the digital numbers to physical quantities, i.e., temperatures, pressures, and accelerations. The project office agreed to obtain telemetry of checkout data from the probe. Work to extend programs written for use on the Pioneer Venus project included: (1) massive heat shield ablation leading to important mass loss during entry; and (2) rapid planet rotation, which introduced

  6. Outer planet entry probe system study. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    1972-01-01

    General mission considerations and science prospectus, which are of a general nature that applies to several or all planetary applications, are presented. Five probe systems are defined: nominal Jupiter probe system, and Jupiter probe-dedicated alternative probe system, Jupiter spacecraft radiation-compatible alternative probe system, Saturn probe system, and Saturn probe applicability for Uranus. Parametric analysis is summarized for mission analysis of a general nature, and then for specific missions to Jupiter, Saturn, Uranus, and Neptune. The program is also discussed from the hardware availability viewpoint and the aspect of commonality.

  7. Compressive Acceleration of Solar Energetic Particles within Coronal Mass Ejections: Observations and Theory Relevant to the Solar Probe Plus and Solar Orbiter Missions

    NASA Astrophysics Data System (ADS)

    Roelof, E. C.

    2015-12-01

    observational technique by which (divV) may be extracted directly from coronograph white-light movies of out-going CMEs, thus offering observational closure of the new theory for SEP acceleration/injection that should be relevant to the Solar Probe Plus and Solar Orbiter missions.

  8. Acceleration Noise Measurements for LISA

    NASA Astrophysics Data System (ADS)

    Schlamminger, Stephan; Gundlach, Jens

    2005-04-01

    The close spacing between the proof mass and the housing in the LISA (Laser Interferometer Space Antenna) spacecraft has been a concern as there may be spurious feeble forces. Such forces may limit the performance of the gravity wave detector at frequencies below 3 mHz and must be studied experimentally. We are performing ultra sensitive torsion balance tests to investigate such effects. Our torsion pendulum and a nearby plate are designed to simulate the LISA proof mass with its adjacent housing surface. We study torque noise on the pendulum as a function of separation between the surfaces. In order to exceed the LISA requirement we are probing the acceleration noise at much closer separations, than those planned for LISA. We have taken data at separations as small as 0.15 mm.

  9. Simulated Prompt Acceleration of Multi-MeV Electrons by the 17 March 2015 Interplanetary Shock

    NASA Astrophysics Data System (ADS)

    Hudson, Mary; Jaynes, Allison; Kress, Brian; Li, Zhao; Patel, Maulik; Shen, Xiao-Chen; Thaller, Scott; Wiltberger, Michael; Wygant, John

    2017-10-01

    Prompt enhancement of relativistic electron flux at L = 3-5 has been reported from Van Allen Probes Relativistic Electron Proton Telescope (REPT) measurements associated with the 17 March 2015 interplanetary shock compression of the dayside magnetosphere. Acceleration by ˜1 MeV is inferred on less than a drift timescale as seen in prior shock compression events, which launch a magnetosonic azimuthal electric field impulse tailward. This impulse propagates from the dayside around the flanks accelerating electrons in drift resonance at the dusk flank. Such longitudinally localized acceleration events produce a drift echo signature which was seen at >1 MeV energy on both Van Allen Probe spacecraft, with sustained observations by Probe B outbound at L = 5 at 2100 MLT at the time of impulse arrival, measured by the Electric Fields and Waves instrument. MHD test particle simulations are presented which reproduce drift echo features observed in the REPT measurements at Probe B, including the energy and pitch angle dependence of drift echoes observed. While the flux enhancement was short lived for this event due to subsequent inward motion of the magnetopause, stronger events with larger electric field impulses, as observed in March 1991 and the Halloween 2003 storm, produce enhancements which can be quantified by the inward radial transport and energization determined by the induction electric field resulting from dayside compression.

  10. Probing the fusion of neutron-rich nuclei with re-accelerated radioactive beams

    DOE PAGES

    Vadas, J.; Singh, Varinderjit; Wiggins, B. B.; ...

    2018-03-27

    Here, we report the first measurement of the fusion excitation functions for 39,47K + 28Si at near-barrier energies. Evaporation residues resulting from the fusion process were identified by direct measurement of their energy and time-of-flight with high geometric efficiency. At the lowest incident energy, the cross section measured for the neutron-rich 47K-induced reaction is ≈6 times larger than that of the β-stable system. This experimental approach, both in measurement and in analysis, demonstrates how to efficiently measure fusion with low-intensity re-accelerated radioactive beams, establishing the framework for future studies.

  11. Probing the fusion of neutron-rich nuclei with re-accelerated radioactive beams

    NASA Astrophysics Data System (ADS)

    Vadas, J.; Singh, Varinderjit; Wiggins, B. B.; Huston, J.; Hudan, S.; deSouza, R. T.; Lin, Z.; Horowitz, C. J.; Chbihi, A.; Ackermann, D.; Famiano, M.; Brown, K. W.

    2018-03-01

    We report the first measurement of the fusion excitation functions for K,4739+28Si at near-barrier energies. Evaporation residues resulting from the fusion process were identified by direct measurement of their energy and time of flight with high geometric efficiency. At the lowest incident energy, the cross section measured for the neutron-rich 47K-induced reaction is ≈6 times larger than that of the β -stable system. This experimental approach, both in measurement and in analysis, demonstrates how to efficiently measure fusion with low-intensity re-accelerated radioactive beams, establishing the framework for future studies.

  12. Probing the fusion of neutron-rich nuclei with re-accelerated radioactive beams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vadas, J.; Singh, Varinderjit; Wiggins, B. B.

    Here, we report the first measurement of the fusion excitation functions for 39,47K + 28Si at near-barrier energies. Evaporation residues resulting from the fusion process were identified by direct measurement of their energy and time-of-flight with high geometric efficiency. At the lowest incident energy, the cross section measured for the neutron-rich 47K-induced reaction is ≈6 times larger than that of the β-stable system. This experimental approach, both in measurement and in analysis, demonstrates how to efficiently measure fusion with low-intensity re-accelerated radioactive beams, establishing the framework for future studies.

  13. Study of entry and landing probes for exploration of Titan

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Saturn's largest moon, Titan, is a totally unique planetary body which is certain to yield exciting new phenomena. Current information is lacking in detail to distinguish between a thin methane rich atmosphere and a thick nitrogen rich atmosphere. Therefore, both the thin and thick atmospheric models were used for the study of various Titan probe classes described in this report. The technical requirements, conceptual design, science return, schedule, cost and mission implications of three probe classes that could be used for exploration of Titan are defined. The three probe classes were based on a wide range of exploration mission possibilities.

  14. An investigation into the effectiveness of smartphone experiments on students’ conceptual knowledge about acceleration

    NASA Astrophysics Data System (ADS)

    Mazzella, Alessandra; Testa, Italo

    2016-09-01

    This study is a first attempt to investigate effectiveness of smartphone-based activities on students’ conceptual understanding of acceleration. 143 secondary school students (15-16 years old) were involved in two types of activities: smartphone- and non-smartphone activities. The latter consisted in data logging and ‘cookbook’ activities. For the sake of comparison, all activities featured the same phenomena, i.e., the motion on an inclined plane and pendulum oscillations. A pre-post design was adopted, using open questionnaires as probes. Results show only weak statistical differences between the smartphone and non-smartphone groups. Students who followed smartphone activities were more able to design an experiment to measure acceleration and to correctly describe acceleration in a free fall motion. However, students of both groups had many difficulties in drawing acceleration vector along the trajectory of the studied motion. Results suggest that smartphone-based activities may be effective substitutes of traditional experimental settings and represent a valuable aid for teachers who want to implement laboratory activities at secondary school level. However, to achieve a deeper conceptual understanding of acceleration, some issues need to be addressed: what is the reference system of the built-in smartphone sensor; relationships between smartphone acceleration graphs and experimental setup; vector representation of the measured acceleration.

  15. A study on leakage radiation dose at ELV-4 electron accelerator bunker

    NASA Astrophysics Data System (ADS)

    Chulan, Mohd Rizal Md; Yahaya, Redzuwan; Ghazali, Abu BakarMhd

    2014-09-01

    Shielding is an important aspect in the safety of an accelerator and the most important aspects of a bunker shielding is the door. The bunker's door should be designed properly to minimize the leakage radiation and shall not exceed the permitted limit of 2.5μSv/hr. In determining the leakage radiation dose that passed through the door and gaps between the door and the wall, 2-dimensional manual calculations are often used. This method is hard to perform because visual 2-dimensional is limited and is also very difficult in the real situation. Therefore estimation values are normally performed. In doing so, the construction cost would be higher because of overestimate or underestimate which require costly modification to the bunker. Therefore in this study, two methods are introduced to overcome the problem such as simulation using MCNPX Version 2.6.0 software and manual calculation using 3-dimensional model from Autodesk Inventor 2010 software. The values from the two methods were eventually compared to the real values from direct measurements using Ludlum Model 3 with Model 44-9 probe survey meter.

  16. A study of the high-precision displacement laser probe

    NASA Astrophysics Data System (ADS)

    Fan, Yuming; Zhang, Guoxiong

    2006-06-01

    On the basis of the measuring principle of the dynamic active optical confocal probe based on time difference measurement that has a reference path, a dynamic active optical confocal probe based on time difference measurement but has no reference path is developed. In this paper, the working principle of this optical confocal probe is dissertated. A large-scale integrated measuring system is designed to simplify the structure of the probe and to enhance the stability of the probe. Single-chip microcomputer system with a high-speed ADC is selected in the measurement and control system of the probe. At the end of the paper, experiments on the performance of the optical confocal probe based on time difference measurement with no reference path are carried out. Experiment results show that the probe has a measuring resolution of 0.05μm, a measuring range of 0.2mm and a linearity of 0.4μm.

  17. GPU-accelerated computation of electron transfer.

    PubMed

    Höfinger, Siegfried; Acocella, Angela; Pop, Sergiu C; Narumi, Tetsu; Yasuoka, Kenji; Beu, Titus; Zerbetto, Francesco

    2012-11-05

    Electron transfer is a fundamental process that can be studied with the help of computer simulation. The underlying quantum mechanical description renders the problem a computationally intensive application. In this study, we probe the graphics processing unit (GPU) for suitability to this type of problem. Time-critical components are identified via profiling of an existing implementation and several different variants are tested involving the GPU at increasing levels of abstraction. A publicly available library supporting basic linear algebra operations on the GPU turns out to accelerate the computation approximately 50-fold with minor dependence on actual problem size. The performance gain does not compromise numerical accuracy and is of significant value for practical purposes. Copyright © 2012 Wiley Periodicals, Inc.

  18. Investigation of Coatings for Langmuir Probes in an Oxygen-Rich Space Environment

    NASA Astrophysics Data System (ADS)

    Samaniego, J. I.; Wang, X.; Andersson, L.; Malaspina, D.; Ergun, R.; Horanyi, M.

    2017-12-01

    The surface properties of the Langmuir probes, such as the one on the MAVEN mission, will change after exposure to upper planetary atmospheres where high concentrations of atomic oxygen and other oxidizing compounds are present. TiN (Titanium Nitride) or DAG (a resin based graphite dispersion) are the most common coatings for current Langmuir probes, yet both of these coatings pose issues when exposed to oxygen-rich space environment. TiN showed reduced surface conductivity while the DAG layers erode with exposure to oxygen. It is known that Iridium (Ir) and Rhenium (Rh) are difficult to oxidize and maintain high conductivity even in their oxidized forms, suggesting them to be good candidates for probe coatings. Oxidation of most metals creates a resistive layer on the surface of the probe that will affect the amount of current being collected at a given voltage during the probe sweep and therefore affect the accuracy of plasma parameters determined by the Langmuir probe (e.g. density, temperature). We present the results of the oxidation effect on the current-voltage curves (I-V curves) and therefore the resulting measured plasma parameters of Ir and Rh wire probes compared with other control metals and coatings (Cu, Ni, TiN) in controlled plasma environments. The oxidation process is performed in an oxygen plasma chamber in which both O+ and O2+ are created and accelerated toward the probes with energies < 10 eV. An argon plasma chamber is used to compare the probe's I-V curves before and after the oxidation process. Our preliminary results indicate that iridium shows the least effect of oxidation on the probe measurements. The second objective of this study is to identify methods that can be used in orbit to clean the surface of Langmuir probes to minimize the effect of exposure to oxidizing compounds.

  19. Physical limitations in sensors for a drag-free deep space probe

    NASA Technical Reports Server (NTRS)

    Juillerat, R.

    1971-01-01

    The inner perturbing forces acting on sensors were analyzed, taking into account the technological limitations imposed on the proof mass position pickup and proof mass acquisition system. The resulting perturbing accelerations are evaluated as a function of the drag-free sensor parameters. Perturbations included gravitational attraction, electrical action, magnetic action, pressure effects, radiation effects, and action of the position pickup. These data can be used to study the laws of guidance, providing an optimization of the space probe as a whole.

  20. Comparative evaluation of probing depth and clinical attachment level using a manual probe and Florida probe.

    PubMed

    Kour, Amandeep; Kumar, Ashish; Puri, Komal; Khatri, Manish; Bansal, Mansi; Gupta, Geeti

    2016-01-01

    To compare and evaluate the intra- and inter-examiner efficacy and reproducibility of the first-generation manual (Williams) probe and the third-generation Florida probe in terms of measuring pocket probing depth (PD) and clinical attachment level (CAL). Forty subjects/4000 sites were included in this comparative, cross-sectional study. Group- and site-wise categorizations were done. Based on gingival index, PD, and CAL, patients were divided into four groups, i.e., periodontally healthy, gingivitis, mild to moderate periodontitis, and severe periodontitis. Further, based on these parameters, a total of 4000 sites, with 1000 sites in each category randomly selected from these 40 patients, were taken. Full mouth PD and CAL measurements were recorded with two probes, by Examiner 1 and on Ramfjord teeth by Examiner 2. Full mouth and Ramfjord teeth group- and site-wise PD obtained with the manual probe by both the examiners were statistically significantly deeper than that obtained with the Florida probe. The full mouth and Ramfjord teeth mean CAL measurement by Florida probe was higher as compared to manual probe in mild to moderate periodontitis group and sites, whereas in severe periodontitis group and sites, manual probe recorded higher CAL as compared to Florida probe. Mean PD and CAL measurements were deeper with the manual probe as compared to the Florida probe in all the groups and sites, except for the mild-moderate periodontitis group and sites where the CAL measurements with the manual probe were less than the Florida probe. Manual probe was more reproducible and showed less interexaminer variability as compared to the Florida probe.

  1. Pitch Angle Dependence of Drift Resonant Ions Observed by the Van Allen Probes

    NASA Astrophysics Data System (ADS)

    Rankin, R.; Wang, C.; Wang, Y.; Zong, Q. G.; Zhou, X.

    2017-12-01

    Acceleration and modulation of ring current ions by poloidal mode ULF waves is investigated. A simplified MHD model of ULF waves in a dipole magnetic field is presented that includes phase mixing to perpendicular scales determined by the ionospheric Pedersen conductivity. The wave model is combined with a full Lorentz force test particle code to study drift and drift bounce resonance wave-particle interactions. Ion trajectories are traced backward-in-time to an assumed form of the distribution function, and Liouville's method is used to reconstruct the phase space density response (PSD) poloidal mode waves observed by the Van Allen Probes. In spite of its apparent simplicity, simulations using the wave and test particle models are able to explain the acceleration of ions and energy dispersion observed by the Van Allen Probes. The paper focuses on the pitch angle evolution of the initial PSD as it responds to the action of ULF waves. An interesting aspect of the study is the formation of butterfly ion distributions as ions make periodic radial oscillations across L. Ions become trapped in an effective potential well across a limited range of L and follow trajectories that cause them to surf along constant phase fronts. The impications of this new trapping mechanism for both ions and electrons is discussed.

  2. Investigations of ultrafast charge dynamics in laser-irradiated targets by a self probing technique employing laser driven protons

    NASA Astrophysics Data System (ADS)

    Ahmed, H.; Kar, S.; Cantono, G.; Nersisyan, G.; Brauckmann, S.; Doria, D.; Gwynne, D.; Macchi, A.; Naughton, K.; Willi, O.; Lewis, C. L. S.; Borghesi, M.

    2016-09-01

    The divergent and broadband proton beams produced by the target normal sheath acceleration mechanism provide the unique opportunity to probe, in a point-projection imaging scheme, the dynamics of the transient electric and magnetic fields produced during laser-plasma interactions. Commonly such experimental setup entails two intense laser beams, where the interaction produced by one beam is probed with the protons produced by the second. We present here experimental studies of the ultra-fast charge dynamics along a wire connected to laser irradiated target carried out by employing a 'self' proton probing arrangement - i.e. by connecting the wire to the target generating the probe protons. The experimental data shows that an electromagnetic pulse carrying a significant amount of charge is launched along the wire, which travels as a unified pulse of 10s of ps duration with a velocity close to speed of light. The experimental capabilities and the analysis procedure of this specific type of proton probing technique are discussed.

  3. Microwaves and particle accelerators: a fundamental link

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chattopadhyay, Swapan

    2011-07-01

    John Cockcroft's splitting of the atom and Ernest Lawrence's invention of the cyclotron in the first half of the twentieth century ushered in the grand era of ever higher energy particle accelerators to probe deeper into matter. It also forged a link, bonding scientific discovery with technological innovation that continues today in the twenty first century. The development of radar and high power vacuum electronics, especially microwave power tubes like the magnetrons and the klystrons in the pre-second world war era, was instrumental in the rapid development of circular and linear charged particle accelerators in the second half of themore » twentieth century. We had harnessed the powerful microwave radio-frequency sources from few tens of MHz to up to 90 GHz spanning L-band to W-band frequencies. Simultaneously in the second half of the twentieth century, lasers began to offer very first opportunities of controlling charged particles at smaller resolutions on the scale of wavelengths of visible light. We also witnessed in this period the emergence of the photon and neutron sciences driven by accelerators built-by-design producing tailored and ultra-bright pulses of bright photons and neutrons to probe structure and function of matter from aggregate to individual molecular and atomic scales in unexplored territories in material and life sciences. As we enter the twenty first century, the race for ever higher energies, brightness and luminosity to probe atto-metric and atto-second domains of the ultra-small structures and ultra-fast processes continues. These developments depend crucially on yet further advancements in the production and control of high power and high frequency microwaves and light sources, often intricately coupled in their operation to the high energy beams themselves. We give a glimpse of the recent developments and innovations in the electromagnetic production and control of charged particle beams in the service of science and society

  4. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Obayashi, T.; Kawashima, N.; Kuriki, K.; Nagatomo, M.; Ninomiya, K.; Sasaki, S.; Ushirokawa, A.; Kudo, I.; Ejiri, M.; Roberts, W. T.

    1982-01-01

    Plans for SEPAC, an instrument array to be used on Spacelab 1 to study vehicle charging and neutralization, beam-plasma interaction in space, beam-atmospheric interaction exciting artificial aurora and airglow, and the electromagnetic-field configuration of the magnetosphere, are presented. The hardware, consisting of electron beam accelerator, magnetoplasma arcjet, neutral-gas plume generator, power supply, diagnostic package (photometer, plasma probes, particle analyzers, and plasma-wave package), TV monitor, and control and data-management unit, is described. The individual SEPAC experiments, the typical operational sequence, and the general outline of the SEPAC follow-on mission are discussed. Some of the experiments are to be joint ventures with AEPI (INS 003) and will be monitored by low-light-level TV.

  5. Radial Diffusion Coefficients Using E and B Field Data from the Van Allen Probes: Comparison with the CRRES Study

    NASA Astrophysics Data System (ADS)

    Ali, A.; Elkington, S. R.; Malaspina, D.

    2014-12-01

    The Van Allen radiation belts contain highly energetic particles which interact with a variety of plasma and MHD waves. Waves with frequencies in the ULF range are understood to play an important role in loss and acceleration of energetic particles. We are investigating the contributions from perturbations in both the magnetic and the electric fields in driving radial diffusion of charged particles and wish to probe two unanswered questions about ULF wave driven radial transport. First, how important are the fluctuations in the magnetic field compared with the fluctuations in the electric field in driving radial diffusion? Second, how does ULF wave power distribution in azimuth affect radial diffusion? Analytic treatments of the diffusion coefficients generally assume uniform distribution of power in azimuth but in situ measurements suggest otherwise. We present results from a study using the electric and magnetic field measurements from the Van Allen Probes to estimate the radial diffusion coefficients as a function of L and Kp. During the lifetime of the RBSP mission to date, there has been a dearth of solar activity. This compels us to consider Kp as the only time and activity dependent parameter instead of solar wind velocity and pressure.

  6. Design of an electromagnetic accelerator for turbulent hydrodynamic mix studies

    NASA Astrophysics Data System (ADS)

    Susoeff, A. R.; Hawke, R. S.; Morrison, J. J.; Dimonte, G.; Remington, B. A.

    1993-12-01

    An electromagnetic accelerator in the form of a linear electric motor (LEM) has been designed to achieve controlled acceleration profiles of a carriage containing hydrodynamically unstable fluids for the investigation of the development of turbulent mix. The Rayleigh-Taylor instability is investigated by accelerating two dissimilar density fluids using the LEM to achieve a wide variety of acceleration and deceleration profiles. The acceleration profiles are achieved by independent control of rail and augmentation currents. A variety of acceleration-time profiles are possible including: (1) constant, (2) impulsive and (3) shaped. The LEM and support structure are a robust design in order to withstand high loads with deflections and to mitigate operational vibration. Vibration of the carriage during acceleration could create artifacts in the data which would interfere with the intended study of the Rayleigh-Taylor instability. The design allows clear access for diagnostic techniques such as laser induced fluorescence radiography, shadowgraphs and particle imaging velocimetry. Electromagnetic modeling codes were used to optimize the rail and augmentation coil positions within the support structure framework. Results of contemporary studies for non-arcing sliding contact of solid armatures are used for the design of the driving armature and the dynamic electromagnetic braking system. A 0.6MJ electrolytic capacitor bank is used for energy storage to drive the LEM. This report will discuss a LEM design which will accelerate masses of up to 3kg to a maximum of about 3000g(sub o), where g(sub o) is accelerated due to gravity.

  7. A comparative study of electrical probe techniques for plasma diagnostics

    NASA Technical Reports Server (NTRS)

    Szuszczewicz, E. P.

    1972-01-01

    Techniques for using electrical probes for plasma diagnostics are reviewed. Specific consideration is given to the simple Langmuir probe, the symmetric double probe of Johnson and Malter, the variable-area probe of Fetz and Oeschsner, and a floating probe technique. The advantages and disadvantages of each technique are discussed.

  8. Plasma-edge studies using carbon resistance probes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wampler, W.R.

    1984-01-01

    Characterization of erosion and hydrogen-recycling processes occurring at the edge of magnetically confined plasmas requires knowledge of the energy and flux of hydrogen isotopes incident on the materials. A new plasma-edge probe technique, the carbon resistance probe, has been developed to obtain this information. This technique uti

  9. Nonlinear friction dynamics on polymer surface under accelerated movement

    NASA Astrophysics Data System (ADS)

    Aita, Yuuki; Asanuma, Natsumi; Takahashi, Akira; Mayama, Hiroyuki; Nonomura, Yoshimune

    2017-04-01

    Nonlinear phenomena on the soft material surface are one of the most exciting topics of chemical physics. However, only a few reports exist on the friction phenomena under accelerated movement, because friction between two solid surfaces is considered a linear phenomenon in many cases. We aim to investigate how nonlinear accelerated motion affects friction on solid surfaces. In the present study, we evaluate the frictional forces between two polytetrafluoroethylene (PTFE) resins using an advanced friction evaluation system. On PTFE surfaces, the normalized delay time δ, which is the time lag in the response of the friction force to the accelerated movement, is observed in the pre-sliding friction process. Under high-velocity conditions, kinetic friction increases with velocity. Based on these experimental results, we propose a two-phase nonlinear model including a pre-sliding process (from the beginning of sliding of a contact probe to the establishment of static friction) and a kinetic friction process. The present model consists of several factors including velocity, acceleration, stiffness, viscosity, and vertical force. The findings reflecting the viscoelastic properties of soft material is useful for various fields such as in the fabrication of clothes, cosmetics, automotive materials, and virtual reality systems as well as for understanding friction phenomena on soft material surfaces.

  10. Parametric study of a pin-plane probe in moderately magnetized plasma

    NASA Astrophysics Data System (ADS)

    Binwal, S.; Gandhi, S.; Kabariya, H.; Karkari, S. K.

    2015-12-01

    The application of a planar Langmuir probe in magnetized plasma is found to be problematic due to significant perturbation of plasma along the magnetic field lines intercepting the probe surface. This causes the Ampere-Volts ‘I e(U)’ characteristics of the probe to deviate from its usual exponential law; in conjunction the electron saturation current I es is significantly reduced. Moreover estimating the electron temperature T e by considering the entire semi-log plot of I e(U) gives ambiguous values of T e. To address this problem, Pitts and Stangeby developed a formula for the reduction factor for I es. This formula depends on a number of uncertain parameters, namely; the ion temperature T +, electron cross-field diffusion coefficient {{D}\\bot ,\\text{e}} and the local potential hill V h estimated by applying a floating pin probe in the vicinity of the planar probe. Due to implicit dependence of these parameters on T e, the resulting analysis is not straightforward. This paper presents a parametric study of different parameters that influence the characteristics of a planar probe in magnetized plasma. For this purpose a pin-plane probe is constructed and applied in the magnetized plasma column. A comprehensive discussion is presented that highlights the practical methodology of using this technique for extracting useful information of plasma parameters in magnetized plasmas.

  11. Progress In Plasma Accelerator Development for Dynamic Formation of Plasma Liners

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Eskridge, Richard; Martin, Adam; Smith, James; Lee, Michael; Cassibry, Jason T.; Griffin, Steven; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    An experimental plasma accelerator for magnetic target fusion (MTF) applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a coaxial pulsed plasma thruster (Figure 1). It has been tested experimentally and plasma jet velocities of approx.50 km/sec have been obtained. The plasma jet has been photographed with 10-ns exposure times to reveal a stable and repeatable plasma structure (Figure 2). Data for velocity profile information has been obtained using light pipes and magnetic probes embedded in the gun walls to record the plasma and current transit respectively at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter is being characterized and future work for second generation "ultra-low jitter" gun development is being identified.

  12. Nasa's Solar Probe Plus Mission and Implications for the Theoretical Understanding of the Heliosphere

    NASA Astrophysics Data System (ADS)

    Velli, Marco

    2012-07-01

    Solar Probe Plus (SPP), one of the most challenging missions to understand the origins of the Heliosphere, will carry a payload consisting of plasma and energetic particle detectors, elec- tromagnetic field antennas and magnetometers, and a white light imager, to the unexplored regions extending from 70 to 8.5 solar radii (0.3 to 0.05 AU) from the photosphere of the Sun. Solar Probe Plus's goals are to understand the extended heating of the solar corona and acceleration of the solar wind,the origins of solar wind structures including high and low speed streams, and the origins of energetic particle acceleration in Coronal Mass Ejections and CMEs. In addition, combined measurements from the white light imager and the EM field antennas will allow the first direct measurements of dust deep in the inner solar system. This presentation will provide a broad context for the mission objectives and measurements and illustrate the likely progress SPP will bring to the understanding of the Heliosphere, stellar winds, and the fundamental physics of particle acceleration, reconnection, collisionless shocks and turbulence in space and astrophysical plasmas.

  13. Laser-Assisted Atom Probe Tomography of Deformed Minerals: A Zircon Case Study.

    PubMed

    La Fontaine, Alexandre; Piazolo, Sandra; Trimby, Patrick; Yang, Limei; Cairney, Julie M

    2017-04-01

    The application of atom probe tomography to the study of minerals is a rapidly growing area. Picosecond-pulsed, ultraviolet laser (UV-355 nm) assisted atom probe tomography has been used to analyze trace element mobility within dislocations and low-angle boundaries in plastically deformed specimens of the nonconductive mineral zircon (ZrSiO4), a key material to date the earth's geological events. Here we discuss important experimental aspects inherent in the atom probe tomography investigation of this important mineral, providing insights into the challenges in atom probe tomography characterization of minerals as a whole. We studied the influence of atom probe tomography analysis parameters on features of the mass spectra, such as the thermal tail, as well as the overall data quality. Three zircon samples with different uranium and lead content were analyzed, and particular attention was paid to ion identification in the mass spectra and detection limits of the key trace elements, lead and uranium. We also discuss the correlative use of electron backscattered diffraction in a scanning electron microscope to map the deformation in the zircon grains, and the combined use of transmission Kikuchi diffraction and focused ion beam sample preparation to assist preparation of the final atom probe tip.

  14. The spinning disc: studying radial acceleration and its damping process with smartphone acceleration sensors

    NASA Astrophysics Data System (ADS)

    Hochberg, K.; Gröber, S.; Kuhn, J.; Müller, A.

    2014-03-01

    Here, we show the possibility of analysing circular motion and acceleration using the acceleration sensors of smartphones. For instance, the known linear dependence of the radial acceleration on the distance to the centre (a constant angular frequency) can be shown using multiple smartphones attached to a revolving disc. As a second example, the decrease of the radial acceleration and the rotation frequency due to friction can be measured and fitted with a quadratic function, in accordance with theory. Finally, because the disc is not set up exactly horizontal, each smartphone measures a component of the gravitational acceleration that adds to the radial acceleration during one half of the period and subtracts from the radial acceleration during the other half. Hence, every graph shows a small modulation, which can be used to determine the rotation frequency, thus converting a ‘nuisance effect’ into a source of useful information, making additional measurements with stopwatches or the like unnecessary.

  15. DNA Probe Pooling for Rapid Delineation of Chromosomal Breakpoints

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Chun-Mei; Kwan, Johnson; Baumgartner, Adolf

    2009-01-30

    Structural chromosome aberrations are hallmarks of many human genetic diseases. The precise mapping of translocation breakpoints in tumors is important for identification of genes with altered levels of expression, prediction of tumor progression, therapy response, or length of disease-free survival as well as the preparation of probes for detection of tumor cells in peripheral blood. Similarly, in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for carriers of balanced, reciprocal translocations benefit from accurate breakpoint maps in the preparation of patient-specific DNA probes followed by a selection of normal or balanced oocytes or embryos. We expedited the process of breakpointmore » mapping and preparation of case-specific probes by utilizing physically mapped bacterial artificial chromosome (BAC) clones. Historically, breakpoint mapping is based on the definition of the smallest interval between proximal and distal probes. Thus, many of the DNA probes prepared for multi-clone and multi-color mapping experiments do not generate additional information. Our pooling protocol described here with examples from thyroid cancer research and PGD accelerates the delineation of translocation breakpoints without sacrificing resolution. The turnaround time from clone selection to mapping results using tumor or IVF patient samples can be as short as three to four days.« less

  16. Probing plasma fluorinated graphene via spectromicroscopy.

    PubMed

    Struzzi, C; Scardamaglia, M; Reckinger, N; Sezen, H; Amati, M; Gregoratti, L; Colomer, J-F; Ewels, C; Snyders, R; Bittencourt, C

    2017-11-29

    Plasma fluorination of graphene is studied using a combination of spectroscopy and microscopy techniques, giving insight into the yield and fluorination mechanism for functionalization of supported graphene with both CF 4 and SF 6 gas precursors. Ion acceleration during fluorination is used to probe the effect on grafting functionalities. Adatom clustering, which occurs with CF 4 plasma treatment, is suppressed when higher kinetic energy is supplied to the ions. During SF 6 plasma functionalization, the sulfur atoms tend to bond to bare copper areas instead of affecting the graphene chemistry, except when the kinetic energy of the ions is restricted. Using scanning photoelectron microscopy, with a 100 nm spatial resolution, the chemical bonding environment is evaluated in the fluorinated carbon network at selected regions and the functionalization homogeneity is controlled in individual graphene flakes.

  17. Free volume distribution of branched poly(methyl methacrylates): Conformational probes study

    NASA Astrophysics Data System (ADS)

    Kamalova, D. I.; Remizov, A. B.

    2016-12-01

    In this work we studied the free volume distribution of the branched poly (methylmethacrylates) by the method of conformational probes. The freezing temperatures of the conformational transitions of the probes introduced into branched polymers were determined by FTIR spectra. The influence of covalently connected fullerene С60 on the freezing temperatures of conformational transitions was shown.

  18. Scanning Probe Microscopies and Their Applications Towards the Study of Superconductors

    NASA Astrophysics Data System (ADS)

    Helfrich, Jennifer Ann

    1995-11-01

    The invention of the scanning tunneling microscope (STM) in 1982 made it possible to study surfaces and structures at resolutions previously believed unattainable. Adapting the STM for low temperatures makes it possible to study superconductors with new methods and to obtain valuable information. This thesis describes a novel low temperature STM (LTSTM) that was designed and built at Northwestern University for the purpose of studying superconductors in the mixed state. At low temperatures, this LTSTM has a scan range an order of magnitude larger than other LTSTM's designed elsewhere. It is capable of low temperature imaging and obtaining dI/dV vs. V curves. A detailed study of magnetic force microscopy (MFM) probes is also presented. The fields and forces between probe and surface were computer modeled. These results are compared with results from electron holographs of MFM probes. The final section of the thesis describes an a.c. susceptibility measurement on a UPt_3 sphere. Results are presented and discussed.

  19. Preentry communications study. Outer planets atmospheric entry probe

    NASA Technical Reports Server (NTRS)

    Hinrichs, C. A.

    1976-01-01

    A pre-entry communications study is presented for a relay link between a Jupiter entry probe and a spacecraft in hyperbolic orbit. Two generic communications links of interest are described: a pre-entry link to a spun spacecraft antenna, and a pre-entry link to a despun spacecraft antenna. The propagation environment of Jupiter is defined. Although this is one of the least well known features of Jupiter, enough information exists to reasonably establish bounds on the performance of a communications link. Within these bounds, optimal carrier frequencies are defined. The next step is to identify optimal relative geometries between the probe and the spacecraft. Optimal trajectories are established for both spun and despun spacecraft antennas. Given the optimal carrier frequencies, and the optimal trajectories, the data carrying capacities of the pre-entry links are defined. The impact of incorporating pre-entry communications into a basic post entry probe is then assessed. This assessment covers the disciplines of thermal control, power source, mass properties and design layout. A conceptual design is developed of an electronically despun antenna for use on a Pioneer class of spacecraft.

  20. Laboratory plasma probe studies

    NASA Technical Reports Server (NTRS)

    Heikkila, W. J.

    1975-01-01

    Diagnostic experiments performed in a collisionless plasma using CO2 as the working gas are described. In particular, simultaneous measurements that have been performed by means of Langmuir- and RF-probes are presented. A resonance occurring above the parallel resonance in the frequency characteristic of a two electrode system is interpreted as being due to the resonant excitation of electroacoustic waves.

  1. Theoretical and Experimental Studies in Accelerator Physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenzweig, James

    accelerator firm. We note also that PBPL graduates remain as close elaborators for the program after leaving UCLA. The UCLA PBPL program is a foremost developer of on-campus facilities, such as the Neptune and Pegasus Laboratories, providing a uniquely strong environment for student-based research. In addition, the PBPL is a strong user of off-campus national lab facilities, such as SLAC FACET and NLCTA, and the BNL ATF. UCLA has also vigorously participated in the development of these facilities. The dual emphases on off- and on-campus opportunities permit the PBPL to address in an agile way a wide selection of cutting-edge research topics. The topics embraced by this proposal illustrate this program aspect well. These include: GV/m dielectric wakefield acceleration/coherent Cerenkov radiation experiments at FACET (E-201) and the ATF; synergistic laser-excited dielectric accelerator and light source development; plasma wakefield (PWFA) experiments on “Trojan horse” ionization injection (FACET E-210), quasi-nonlinear PWFA at BNL and the production at Neptune high transformer ratio plasma wakes; the inauguration of a new type of RF photoinjector termed “hybrid” at UCLA, and application to PWFA; space-charge dominated beam and cathode/near cathode physics; the study of advanced IFEL systems, for very high energy gain and utilization of novel OAM modes; the physcis of inverse Compton scattering (ICS), with applications to e+ production and γγ colliders; electron diffraction; and advanced beam diagnostics using coherent imaging techniques. These subjects are addressed under the leadership of PBPL director Prof. James Rosenzweig in Task A, and Prof. Pietro Musumeci in Task J, which was initiated following his OHEP Outstanding Junior Investigator award.« less

  2. Intrinsic beam emittance of laser-accelerated electrons measured by x-ray spectroscopic imaging.

    PubMed

    Golovin, G; Banerjee, S; Liu, C; Chen, S; Zhang, J; Zhao, B; Zhang, P; Veale, M; Wilson, M; Seller, P; Umstadter, D

    2016-04-19

    The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the effects of space charge during free-space propagation. Direct experimental measurement of this important property is complicated by micron-scale beam sizes, and the presence of intense fields at the location where space charge acts. Reported here is a novel, non-destructive, single-shot method that overcame this problem. It employed an intense laser probe pulse, and spectroscopic imaging of the inverse-Compton scattered x-rays, allowing measurement of an ultra-low value for the normalized transverse emittance, 0.15 (±0.06) π mm mrad, as well as study of its subsequent growth upon exiting the accelerator. The technique and results are critical for designing multi-stage laser-wakefield accelerators, and generating high-brightness, spatially coherent x-rays.

  3. Intrinsic beam emittance of laser-accelerated electrons measured by x-ray spectroscopic imaging

    DOE PAGES

    Golovin, G.; Banerjee, S.; Liu, C.; ...

    2016-04-19

    Here, the recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the effects of space charge during free-space propagation. Direct experimental measurement of this important property is complicated by micron-scale beam sizes, and the presence of intense fields at the location where space charge acts. Reported here is a novel, non-destructive, single-shot method that overcame this problem. It employed an intense lasermore » probe pulse, and spectroscopic imaging of the inverse-Compton scattered x-rays, allowing measurement of an ultra-low value for the normalized transverse emittance, 0.15 (±0.06) π mm mrad, as well as study of its subsequent growth upon exiting the accelerator. The technique and results are critical for designing multi-stage laser-wakefield accelerators, and generating high-brightness, spatially coherent x-rays.« less

  4. Investigation of the characteristics of the Venus stratosphere from acceleration measurements during the braking of the Venera-13 and Venera-14 probes

    NASA Astrophysics Data System (ADS)

    Avduevskii, V. S.; Godnev, A. G.; Semenchenko, V. V.; Uspenskii, G. R.; Cheremukhina, Z. P.

    1983-03-01

    Acceleration measurements in the preparachute segment of descent during the aerodynamics braking of Venera-13 and Venera-14 were made in order to study the characteristics of the Venus stratosphere and mesosphere. Results of axial-acceleration measurements are presented, and attention is given to atmospheric density and pressure profiles obtained from the accelerometer data and vertical temperature profiles acquired from Venera and Pioneer-Venus acceleration data.

  5. Intra-operative probe for brain cancer: feasibility study

    NASA Astrophysics Data System (ADS)

    Vu Thi, M. H.; Charon, Y.; Duval, M. A.; Lefebvre, F.; Menard, L.; Pitre, S.; Pinot, L.; Siebert, R.

    2007-07-01

    The present work aims a new medical probe for surgeons devoted to brain cancers, in particular glioblastoma multiforme. Within the last years, our group has started the development of a new intra-operative beta imaging probe. More recently, we took an alternative approach for the same application: a fluorescence probe. In both cases the purpose is to differentiate normal from tumor brain tissue. In a first step, we developed set-ups capable to measure autofluorescence. They are based on a dedicated epi-fluorescence design and on specific fiber optic probes. Relative signal amplitude, spectral shape and fluorescence lifetime measurements are foreseen to distinguish normal and cancer tissue by analyzing fluorophores like NADH, lipopigments and porphyrines. The autofluorescence spectra are recorded in the 460-640 nm range with a low resolution spectrometer. For lifetime measurements a fast detector (APD) is used together with a TCSPC-carte. Intrinsic wavelength- and time-resolutions are a few nm and 200 ps, respectively. Different samples have been analyzed to validate our new detection system and to allow a first configuration of our medical fluorescence probe. First results from the tissue measurements are shown.

  6. Fluorescence Dynamics of a FRET Probe Designed for Crowding Studies.

    PubMed

    Currie, Megan; Leopold, Hannah; Schwarz, Jacob; Boersma, Arnold J; Sheets, Erin D; Heikal, Ahmed A

    2017-06-15

    Living cells are crowded with macromolecules and organelles. As a result, there is an urgent need for molecular sensors for quantitative, site-specific assessment of the macromolecular crowding effects on a myriad of biochemical processes toward quantitative cell biology and biophysics. Here we investigate the excited-state dynamics and translational diffusion of a novel FRET sensor (mCerulean-linker-mCitrine) in a buffer (PBS, pH 7.4) at room temperature. Complementary experiments were carried out on free CFP, YFP, and the cleaved FRET probe as controls. The wavelength-dependent fluorescence lifetime measurements of the donor and acceptor in the FRET probe, using the time-correlated single-photon counting technique, indicate an energy transfer efficiency of 6.8 ± 0.9% in PBS, with distinct excited-state dynamics from the recombinant CFP and YFP. The estimated mCerulean-mCitrine distance in this FRET probe is 7.7 ± 0.2 nm. The energy transfer efficiency increases (11.5 ± 0.9%) as the concentration of Ficoll-70 increases over the range of 0-300 g/L with an estimated mCerulean-mCitrine distance of 6.1 ± 0.2 nm. Complementary time-resolved anisotropy measurements suggest that the rotational diffusion of hetero-FRET in PBS is sensitive to the energy transfer from the donor to the acceptor. The results also suggest that the linker, -(GSG) 6 A(EAAAK) 6 A(GSG) 6 A(EAAAK) 6 A(GSG) 6 -, is rather flexible, and the observed rotational dynamics is likely to be due to a segmental mobility of the FRET pairs rather than an overall tumbling motion of a rigid probe. Comparative studies on a new construct of a FRET probe with a shorter, more flexible linker, mCerulean-(GSG) 18 -mCitrine, reveal enhanced energy transfer efficiency. On the millisecond time scale, fluorescence fluctuation analyses of the acceptor (excited at 488 nm) provide a means to examine the translational diffusion coefficient of the FRET probe. The results also suggest that the linker is flexible in this

  7. Peaks in Phase Space Density: A Survey of the Van Allen Probes Era

    NASA Astrophysics Data System (ADS)

    Boyd, A. J.; Turner, D. L.; Reeves, G. D.; Spence, H. E.

    2017-12-01

    One of the challenges of radiation belt studies is the differentiation between acceleration mechanisms, particularly local acceleration and radial diffusion. This is often done through careful examination of phase space density profiles in terms of adiabatic coordinates. In particular, local acceleration processes produce growing peaks in phase space density. Many previous studies have shown clear observations of these features for individual events. However, it remains unclear how often and where these growing peaks are observed over a long time period. With the availability of several years of high quality observations from multiple spacecraft, we now have an opportunity to quantify phase space density profiles not only for multiple events, but also across a wide range of energies. In this study, we examine phase space density from more than four years of data from the Van Allen Probes and THEMIS to determine the statistical properties of the observed peaks in phase space density. First, we determine how often growing peaks are observed. Second, we examine where the peaks are located in terms of the adiabatic invariants mu, K and L* and how these locations relate to geomagnetic indices, solar wind conditions and the plasmapause location. Third, we explore how these peaks evolve in time. Together, these results will reveal the relative importance of different acceleration processes and how these affect the various electron populations within the radiation belt.

  8. Wavefront-sensor-based electron density measurements for laser-plasma accelerators.

    PubMed

    Plateau, G R; Matlis, N H; Geddes, C G R; Gonsalves, A J; Shiraishi, S; Lin, C; van Mourik, R A; Leemans, W P

    2010-03-01

    Characterization of the electron density in laser produced plasmas is presented using direct wavefront analysis of a probe laser beam. The performance of a laser-driven plasma-wakefield accelerator depends on the plasma wavelength and hence on the electron density. Density measurements using a conventional folded-wave interferometer and using a commercial wavefront sensor are compared for different regimes of the laser-plasma accelerator. It is shown that direct wavefront measurements agree with interferometric measurements and, because of the robustness of the compact commercial device, offer greater phase sensitivity and straightforward analysis, improving shot-to-shot plasma density diagnostics.

  9. Wavefront-sensor-based electron density measurements for laser-plasma accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Plateau, Guillaume; Matlis, Nicholas; Geddes, Cameron

    2010-02-20

    Characterization of the electron density in laser produced plasmas is presented using direct wavefront analysis of a probe laser beam. The performance of a laser-driven plasma-wakefield accelerator depends on the plasma wavelength, hence on the electron density. Density measurements using a conventional folded-wave interferometer and using a commercial wavefront sensor are compared for different regimes of the laser-plasma accelerator. It is shown that direct wavefront measurements agree with interferometric measurements and, because of the robustness of the compact commercial device, have greater phase sensitivity, straightforward analysis, improving shot-to-shot plasma-density diagnostics.

  10. Cyclotron Acceleration of Relativistic Electrons through Landau Resonance with Obliquely Propagating Whistler Mode Chorus Emissions

    NASA Astrophysics Data System (ADS)

    Omura, Y.; Hsieh, Y. K.; Foster, J. C.; Erickson, P. J.; Kletzing, C.; Baker, D. N.

    2017-12-01

    A recent test particle simulation of obliquely propagating whistler mode wave-particle interaction [Hsieh and Omura, 2017] shows that the perpendicular wave electric field can play a significant role in trapping and accelerating relativistic electrons through Landau resonance. A further theoretical and numerical investigation verifies that there occurs nonlinear wave trapping of relativistic electrons by the nonlinear Lorentz force of the perpendicular wave magnetic field. An electron moving with a parallel velocity equal to the parallel phase velocity of an obliquely propagating wave basically see a stationary wave phase. Since the electron position is displaced from its gyrocenter by a distance ρ*sin(φ), where ρ is the gyroradius and φ is the gyrophase, the wave phase is modulated with the gyromotion, and the stationary wave fields as seen by the electron are expanded as series of Bessel functions Jn with phase variations n*φ. The J1 components of the wave electric and magnetic fields rotate in the right-hand direction with the gyrofrequency, and they can be in resonance with the electron undergoing the gyromotion, resulting in effective electron acceleration and pitch angle scattering. We have performed a subpacket analysis of chorus waveforms observed by the Van Allen Probes [Foster et al., 2017], and calculated the energy gain by the cyclotron acceleration through Landau resonance. We compare the efficiencies of accelerations by cyclotron and Landau resonances in typical events of rapid electron acceleration observed by the Van Allen Probes.References:[1] Hsieh, Y.-K., and Y. Omura (2017), Nonlinear dynamics of electrons interacting with oblique whistler mode chorus in the magnetosphere, J. Geophys. Res. Space Physics, 122, 675-694, doi:10.1002/2016JA023255.[2] Foster, J. C., P. J. Erickson, Y. Omura, D. N. Baker, C. A. Kletzing, and S. G. Claudepierre (2017), Van Allen Probes observations of prompt MeV radiation belt electron acceleration in nonlinear

  11. Significance of acceleration period in a dynamic strength testing study.

    PubMed

    Chen, W L; Su, F C; Chou, Y L

    1994-06-01

    The acceleration period that occurs during isokinetic tests may provide valuable information regarding neuromuscular readiness to produce maximal contraction. The purpose of this study was to collect the normative data of acceleration time during isokinetic knee testing, to calculate the acceleration work (Wacc), and to determine the errors (ERexp, ERwork, ERpower) due to ignoring Wacc during explosiveness, total work, and average power measurements. Seven male and 13 female subjects attended the test by using the Cybex 325 system and electronic stroboscope machine for 10 testing speeds (30-300 degrees/sec). A three-way ANOVA was used to assess gender, direction, and speed factors on acceleration time, Wacc, and errors. The results indicated that acceleration time was significantly affected by speed and direction; Wacc and ERexp by speed, direction, and gender; and ERwork and ERpower by speed and gender. The errors appeared to increase when testing the female subjects, during the knee flexion test, or when speed increased. To increase validity in clinical testing, it is important to consider the acceleration phase effect, especially in higher velocity isokinetic testing or for weaker muscle groups.

  12. Linear servomotor probe drive system with real-time self-adaptive position control for the Alcator C-Mod tokamak

    NASA Astrophysics Data System (ADS)

    Brunner, D.; Kuang, A. Q.; LaBombard, B.; Burke, W.

    2017-07-01

    A new servomotor drive system has been developed for the horizontal reciprocating probe on the Alcator C-Mod tokamak. Real-time measurements of plasma temperature and density—through use of a mirror Langmuir probe bias system—combined with a commercial linear servomotor and controller enable self-adaptive position control. Probe surface temperature and its rate of change are computed in real time and used to control probe insertion depth. It is found that a universal trigger threshold can be defined in terms of these two parameters; if the probe is triggered to retract when crossing the trigger threshold, it will reach the same ultimate surface temperature, independent of velocity, acceleration, or scrape-off layer heat flux scale length. In addition to controlling the probe motion, the controller is used to monitor and control all aspects of the integrated probe drive system.

  13. Study of strength kinetics of sand concrete system of accelerated hardening

    NASA Astrophysics Data System (ADS)

    Sharanova, A. V.; Lenkova, D. A.; Panfilova, A. D.

    2018-04-01

    Methods of calorimetric analysis are used to study the dynamics of the hydration processes of concretes with different accelerator contents. The efficiency of the isothermal calorimetry method is shown for study of strength kinetics of concrete mixtures of accelerated hardening, promising for additive technologies in civil engineering.

  14. Particle Acceleration at the Sun and in the Heliosphere

    NASA Technical Reports Server (NTRS)

    Reames, Donald V.

    1999-01-01

    Energetic particles are accelerated in rich profusion at sites throughout the heliosphere. They come from solar flares in the low corona, from shock waves driven outward by coronal mass ejections (CMEs), from planetary magnetospheres and bow shocks. They come from corotating interaction regions (CIRs) produced by high-speed streams in the solar wind, and from the heliospheric termination shock at the outer edge of the heliospheric cavity. We sample all these populations near Earth, but can distinguish them readily by their element and isotope abundances, ionization states, energy spectra, angular distributions and time behavior. Remote spacecraft have probed the spatial distributions of the particles and examined new sources in situ. Most acceleration sources can be "seen" only by direct observation of the particles; few photons are produced at these sites. Wave-particle interactions are an essential feature in acceleration sources and, for shock acceleration, new evidence of energetic-proton-generated waves has come from abundance variations and from local cross-field scattering. Element abundances often tell us the physics the source plasma itself, prior to acceleration. By comparing different populations, we learn more about the sources, and about the physics of acceleration and transport, than we can possibly learn from one source alone.

  15. Physiological Effects of Acceleration Observed During a Centrifuge Study of Pilot Performance

    NASA Technical Reports Server (NTRS)

    Smedal, Harald A.; Creer, Brent Y.; Wingrove, Rodney C.

    1960-01-01

    An investigation was conducted by the National Aeronautics and Space Administration, Ames Research Center, and the Naval Air Development Center, Aviation Medical Acceleration Laboratory, to study the effects of acceleration on pilot performance and to obtain some meaningful data for use in establishing tolerance to acceleration levels. The flight simulator used in the study was the Johnsville centrifuge operated as a closed loop system. The pilot was required to perform a control task in various sustained acceleration fields typical of those that Might be encountered by a pilot flying an entry vehicle in which he is seated in a forward-facing position. A special restraint system was developed and designed to increase the pilot's tolerance to these accelerations. The results of this study demonstrated that a well-trained subject, such as a test pilot, can adequately carry out a control task during moderately high accelerations for prolonged periods of time. The maximum levels of acceleration tolerated were approximately 6 times that of gravity for approximately 6 minutes, and varied slightly with the acceleration direction. The tolerance runs were in each case terminated by the subject. In all but two instances, the cause was extreme fatigue. On two occasions the subject terminated the run when he "grayed out." Although there were subjective and objective findings involving the visual and cardiovascular systems, the respiratory system yielded the more critical limiting factors. It would appear that these limiting factors were less severe during the "eyeballs-out" accelerations when compared with the "eyeballs-in" accelerations. These findings are explained on the basis of the influence that the inertial forces of acceleration have on the mechanics of respiration. A condensed version of this report was presented at the Annual Meeting of the Aerospace Medical Association, Miami Beach, May 5-11, 1960, in a paper entitled "Ability of Pilots to Perform a Control Task in

  16. Mercury ion thruster research, 1977. [plasma acceleration

    NASA Technical Reports Server (NTRS)

    Wilbur, P. J.

    1977-01-01

    The measured ion beam divergence characteristics of two and three-grid, multiaperture accelerator systems are presented. The effects of perveance, geometry, net-to-total accelerating voltage, discharge voltage and propellant are examined. The applicability of a model describing doubly-charged ion densities in mercury thrusters is demonstrated for an 8-cm diameter thruster. The results of detailed Langmuir probing of the interior of an operating cathode are given and used to determine the ionization fraction as a function of position upstream of the cathode orifice. A mathematical model of discharge chamber electron diffusion and collection processes is presented along with scaling laws useful in estimating performance of large diameter and/or high specific impluse thrusters. A model describing the production of ionized molecular nitrogen in ion thrusters is included.

  17. A study on task difficulty and acceleration stress

    NASA Technical Reports Server (NTRS)

    Repperger, D. W.; Rogers, D. B.

    1981-01-01

    The results of two experiments which relate to task difficulty and the effects of environmental stress on tracking performance are discussed and compared to subjective evaluations. The first experiment involved five different sum of sine tracking tasks which humans tracked both in a static condition and under a 5 Gz acceleration stress condition. The second experiment involved similar environmental stress conditions but in this case the tasks were constructed from deterministic functions with specially designed velocity and acceleration profiles. Phase Plane performance analysis was conducted to study potential measures of workload or tracking difficulty.

  18. Growth of Cosmic Structure: Probing Dark Energy Beyond Expansion

    DOE PAGES

    Huterer, Dragan; Kirkby, David; Bean, Rachel; ...

    2014-03-15

    The quantity and quality of cosmic structure observations have greatly accelerated in recent years, and further leaps forward will be facilitated by imminent projects. These will enable us to map the evolution of dark and baryonic matter density fluctuations over cosmic history. The way that these fluctuations vary over space and time is sensitive to several pieces of fundamental physics: the primordial perturbations generated by GUT-scale physics; neutrino masses and interactions; the nature of dark matter and dark energy. We focus on the last of these here: the ways that combining probes of growth with those of the cosmic expansionmore » such as distance-redshift relations will pin down the mechanism driving the acceleration of the Universe.« less

  19. Growth of Cosmic Structure: Probing Dark Energy Beyond Expansion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huterer, Dragan; Kirkby, David; Bean, Rachel

    The quantity and quality of cosmic structure observations have greatly accelerated in recent years, and further leaps forward will be facilitated by imminent projects. These will enable us to map the evolution of dark and baryonic matter density fluctuations over cosmic history. The way that these fluctuations vary over space and time is sensitive to several pieces of fundamental physics: the primordial perturbations generated by GUT-scale physics; neutrino masses and interactions; the nature of dark matter and dark energy. We focus on the last of these here: the ways that combining probes of growth with those of the cosmic expansionmore » such as distance-redshift relations will pin down the mechanism driving the acceleration of the Universe.« less

  20. Refractory clad transient internal probe for magnetic field measurements in high temperature plasmas

    NASA Astrophysics Data System (ADS)

    Kim, Hyundae; Cellamare, Vincent; Jarboe, Thomas R.; Mattick, Arthur T.

    2005-05-01

    The transient internal probe (TIP) is a diagnostic for local internal field measurements in high temperature plasmas. A verdet material, which rotates the polarization angle of the laser light under magnetic fields, is launched into a plasma at about 1.8km/s. A linearly polarized Ar+ laser illuminates the probe in transit and the light retroreflected from the probe is analyzed to determine the local magnetic field profiles. The TIP has been used for magnetic field measurements on the helicity injected torus where electron temperature Te⩽80eV. In order to apply the TIP in higher temperature plasmas, refractory clad probes have been developed utilizing a sapphire tube, rear disc, and a MgO window on the front. The high melting points of these refractory materials should allow probe operation at plasma electron temperatures up to Te˜300eV. A retroreflecting probe has also been developed using "catseye" optics. The front window is replaced with a plano-convex MgO lens, and the back surface of the probe is aluminized. This approach reduces spurious polarization effects and provides refractory cladding for the probe entrance face. In-flight measurements of a static magnetic field demonstrate the ability of the clad probes to withstand gun-launch acceleration, and provide high accuracy measurements of magnetic field.

  1. Improvements in Electron-Probe Microanalysis: Applications to Terrestrial, Extraterrestrial, and Space-Grown Materials

    NASA Technical Reports Server (NTRS)

    Carpenter, Paul; Armstrong, John

    2004-01-01

    Improvement in the accuracy of electron-probe microanalysis (EPMA) has been accomplished by critical assessment of standards, correction algorithms, and mass absorption coefficient data sets. Experimental measurement of relative x-ray intensities at multiple accelerating potential highlights errors in the absorption coefficient. The factor method has been applied to the evaluation of systematic errors in the analysis of semiconductor and silicate minds. Accurate EPMA of Martian soil stimulant is necessary in studies that build on Martian rover data in anticipation of missions to Mars.

  2. A close-up of the sun. [solar probe mission planning conference

    NASA Technical Reports Server (NTRS)

    Neugebauer, M. (Editor); Davies, R. W. (Editor)

    1978-01-01

    NASA's long-range plan for the study of solar-terrestrial relations includes a Solar Probe Mission in which a spacecraft is put into an eccentric orbit with perihelion near 4 solar radii (0.02 AU). The scientific experiments which might be done with such a mission are discussed. Topics include the distribution of mass within the Sun, solar angular momentum, the fine structure of the solar surface and corona, the acceleration of the solar wind and energetic particles, and the evolution of interplanetary dust. The mission could also contribute to high-accuracy tests of general relativity and the search for cosmic gravitational radiation.

  3. Electron acceleration behind a wavy dipolarization front

    NASA Astrophysics Data System (ADS)

    Wu, Mingyu; Lu, Quanming; Volwerk, Martin; Nakamura, Rumi; Zhang, Tielong

    2018-02-01

    In this paper, with the in-situ observations from the Time History of Events and Macroscale Interactions during Substorms (THEMIS) probes we report a wavy dipolarization front (DF) event, where the DF has different magnetic structures and electron distributions at different y positions in the Geocentric Solar Magnetospheric (GSM) coordinates. At y ˜2.1RE (RE is the radius of Earth), the DF has a relatively simple structure, which is similar to that of a conventional DF. At y ˜3.0RE, the DF is revealed to have a multiple DF structure, where the plasma exhibits a vortex flow. Such a wavy DF could be the results of the interchange instability. The different structure of such a wavy DF at different sites has a great effect on electron acceleration. Fermi acceleration can occur at the site of the DF with a simple or multiple DF structure, while betatron acceleration as a local process has the contribution to energetic electrons only at the site of the DF with a simple structure.

  4. A Preliminary Study of a Solar-Probe Mission

    NASA Technical Reports Server (NTRS)

    Dugan, Duane W.

    1961-01-01

    A preliminary study is made of some problems associated with the sending of an instrumented probe close to the Sun for the purpose of gathering and telemetering back to Earth information concerning solar phenomena and circumsolar space. The problems considered are primarily those relating to heating and to launch requirements. A nonanalytic discussion of the communications problem of a solar-probe mission is presented to obtain order-of-magnitude estimates of the output and weight of an auxiliary power supply which might be required. From the study it is believed that approaches to the Sun as close as about 4 or 5 million miles do not present insuperable difficulties insofar as heating and communications are concerned. Guidance requirements, in general, do not appear to be stringent. However, in terms of current experience, velocity requirements may be large. It is found, for example, that to achieve perihelion distances between the orbit of Mercury and the visible disc of the Sun, total burnout velocities ranging between 50,000 and 100,000 feet per second are required.

  5. Three Component Velocity and Acceleration Measurement Using FLEET

    NASA Technical Reports Server (NTRS)

    Danehy, Paul M.; Bathel, Brett F.; Calvert, Nathan; Dogariu, Arthur; Miles, Richard P.

    2014-01-01

    The femtosecond laser electronic excitation and tagging (FLEET) method has been used to measure three components of velocity and acceleration for the first time. A jet of pure N2 issuing into atmospheric pressure air was probed by the FLEET system. The femtosecond laser was focused down to a point to create a small measurement volume in the flow. The long-lived lifetime of this fluorescence was used to measure the location of the tagged particles at different times. Simultaneous images of the flow were taken from two orthogonal views using a mirror assembly and a single intensified CCD camera, allowing two components of velocity to be measured in each view. These different velocity components were combined to determine three orthogonal velocity components. The differences between subsequent velocity components could be used to measure the acceleration. Velocity accuracy and precision were roughly estimated to be +/-4 m/s and +/-10 m/s respectively. These errors were small compared to the approx. 100 m/s velocity of the subsonic jet studied.

  6. Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies.

    PubMed

    Ahl, Patrick L; Mensch, Christopher; Hu, Binghua; Pixley, Heidi; Zhang, Lan; Dieter, Lance; Russell, Ryann; Smith, William J; Przysiecki, Craig; Kosinski, Mike; Blue, Jeffrey T

    2016-10-01

    Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output based on formulation input factors such as pH, ionic strength, and excipients. Thermal stability predictions, however, are not enough for regulators. Stability claims must be supported by experimental data. The Quality by Design approach of Design of Experiment (DoE) is well suited to describe formulation outputs such as thermal stability in terms of formulation input factors. A DoE approach particularly at elevated temperatures that induce accelerated degradation can provide empirical understanding of how vaccine formulation input factors and interactions affect vaccine stability output performance. This is possible even when clear scientific understanding of particular formulation stability mechanisms are lacking. A DoE approach was used in an accelerated 37(°)C stability study of an aluminum adjuvant Neisseria meningitidis serogroup B vaccine. Formulation stability differences were identified after only 15 days into the study. We believe this study demonstrates the power of combining DoE methodology with accelerated stress stability studies to accelerate and improve vaccine formulation development programs particularly during the preformulation stage. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  7. Accelerated cure of phenol-formaldehyde resins : studies with model compounds

    Treesearch

    Anthony H. Conner; Linda F. Lorenz; Kolby C. Hirth

    2002-01-01

    2-Hydroxymethylphenol (2-HMP) and 4-hydroxymethylphenol (4-HMP) were used as model compounds to study the reactions that occur during cure of phenol-formaldehyde (PF) resin to which cure accelerators (ethyl formate, propylene carbonate, g-butyrolactone, and triacetin) have been added. The addition of cure accelerators significantly increased the rate of condensation...

  8. Constraints on the extremely high-energy cosmic ray accelerators from classical electrodynamics

    NASA Astrophysics Data System (ADS)

    Aharonian, F. A.; Belyanin, A. A.; Derishev, E. V.; Kocharovsky, V. V.; Kocharovsky, Vl. V.

    2002-07-01

    We formulate the general requirements, set by classical electrodynamics, on the sources of extremely high-energy cosmic rays (EHECRs). It is shown that the parameters of EHECR accelerators are strongly limited not only by the particle confinement in large-scale magnetic fields or by the difference in electric potentials (generalized Hillas criterion) but also by the synchrotron radiation, the electro-bremsstrahlung, or the curvature radiation of accelerated particles. Optimization of these requirements in terms of an accelerator's size and magnetic field strength results in the ultimate lower limit to the overall source energy budget, which scales as the fifth power of attainable particle energy. Hard γ rays accompanying generation of EHECRs can be used to probe potential acceleration sites. We apply the results to several populations of astrophysical objects-potential EHECR sources-and discuss their ability to accelerate protons to 1020 eV and beyond. The possibility of gain from ultrarelativistic bulk flows is addressed, with active galactic nuclei and gamma-ray bursts being the examples.

  9. Constraints on the extremely high-energy cosmic rays accelerators from classical electrodynamics

    NASA Astrophysics Data System (ADS)

    Belyanin, A.; Aharonian, F.; Derishev, E.; Kocharovsky, V.; Kocharovsky, V.

    We formulate the general requirements, set by classical electrodynamics, to the sources of extremely high-energy cosmic rays (EHECRs). It is shown that the parameters of EHECR accelerators are strongly limited not only by the particle confinement in large-scale magnetic field or by the difference in electric potentials (generalized Hillas criterion), but also by the synchrotron radiation, the electro-bremsstrahlung, or the curvature radiation of accelerated particles. Optimization of these requirements in terms of accelerator's size and magnetic field strength results in the ultimate lower limit to the overall source energy budget, which scales as the fifth power of attainable particle energy. Hard gamma-rays accompanying generation of EHECRs can be used to probe potential acceleration sites. We apply the results to several populations of astrophysical objects - potential EHECR sources - and discuss their ability to accelerate protons to 1020 eV and beyond. A possibility to gain from ultrarelativistic bulk flows is addressed, with Active Galactic Nuclei and Gamma-Ray Bursts being the examples.

  10. Diffusion studies on permeable nitroxyl spin probes through bilayer lipid membranes: A low frequency ESR study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meenakumari, V.; Benial, A. Milton Franklin, E-mail: miltonfranklin@yahoo.com; Utsumi, Hideo

    2015-06-24

    Electron spin resonance (ESR) studies were carried out for permeable 2mM {sup 14}N-labeled deutrated 3 Methoxy carbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) in pure water and 1mM, 2mM, 3mM, 4mM concentration of 14N-labeled deutrated MC-PROXYL in 400mM concentration of liposomal solution by using a 300 MHz ESR spectrometer. The ESR parameters such as linewidth, hyperfine coupling constant, g-factor, partition parameter and permeability were reported for these samples. The line broadening was observed for the nitroxyl spin probe in the liposomal solution. The line broadening indicates that the high viscous nature of the liposomal solution. The partition parameter and permeability values indicate the maximum diffusion ofmore » nitroxyl spin probes in the bilayer lipid membranes at 2 mM concentration of nitroxyl radical. This study illustrates that ESR can be used to differentiate between the intra and extra- membrane water by loading the liposome vesicles with a lipid-permeable nitroxyl spin probe. From the ESR results, the spin probe concentration was optimized as 2mM in liposomal solution for ESR phantom studies/imaging, invivo and invitro experiments.« less

  11. Ponderomotive electron acceleration in a silicon-based nanoplasmonic waveguide.

    PubMed

    Sederberg, S; Elezzabi, A Y

    2014-10-17

    Ponderomotive electron acceleration is demonstrated in a semiconductor-loaded nanoplasmonic waveguide. Photogenerated free carriers are accelerated by the tightly confined nanoplasmonic fields and reach energies exceeding the threshold for impact ionization. Broadband (375 nm ≤ λ ≤ 650  nm) white light emission is observed from the nanoplasmonic waveguides. Exponential growth of visible light emission confirms the exponential growth of the electron population, demonstrating the presence of an optical-field-driven electron avalanche. Electron sweeping dynamics are visualized using pump-probe measurements, and a sweeping time of 1.98 ± 0.40 ps is measured. These findings offer a means to harness the potential of the emerging field of ultrafast nonlinear nanoplasmonics.

  12. A cocoon of freshly accelerated cosmic rays detected by Fermi in the Cygnus superbubble.

    PubMed

    Ackermann, M; Ajello, M; Allafort, A; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Belfiore, A; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bottacini, E; Brigida, M; Bruel, P; Buehler, R; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cecchi, C; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; de Angelis, A; de Palma, F; Dermer, C D; do Couto E Silva, E; Drell, P S; Dumora, D; Favuzzi, C; Fegan, S J; Focke, W B; Fortin, P; Fukazawa, Y; Fusco, P; Gargano, F; Germani, S; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, I A; Guillemot, L; Guiriec, S; Hadasch, D; Hanabata, Y; Harding, A K; Hayashida, M; Hayashi, K; Hays, E; Jóhannesson, G; Johnson, A S; Kamae, T; Katagiri, H; Kataoka, J; Kerr, M; Knödlseder, J; Kuss, M; Lande, J; Latronico, L; Lee, S-H; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Martin, P; Mazziotta, M N; McEnery, J E; Mehault, J; Michelson, P F; Mitthumsiri, W; Mizuno, T; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Naumann-Godo, M; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Okumura, A; Orlando, E; Ormes, J F; Ozaki, M; Paneque, D; Parent, D; Pesce-Rollins, M; Pierbattista, M; Piron, F; Pohl, M; Prokhorov, D; Rainò, S; Rando, R; Razzano, M; Reposeur, T; Ritz, S; Parkinson, P M Saz; Sgrò, C; Siskind, E J; Smith, P D; Spinelli, P; Strong, A W; Takahashi, H; Tanaka, T; Thayer, J G; Thayer, J B; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Troja, E; Uchiyama, Y; Vandenbroucke, J; Vasileiou, V; Vianello, G; Vitale, V; Waite, A P; Wang, P; Winer, B L; Wood, K S; Yang, Z; Zimmer, S; Bontemps, S

    2011-11-25

    The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.

  13. Compact Torus Acceleration and Injection Experiment

    NASA Astrophysics Data System (ADS)

    Fukumoto, Naoyuki; Fujiwara, Makoto; Nagata, Masayoshi; Uyama, Tadao; Oda, Yasushi; Azuma, Kingo

    1996-11-01

    The spheromak-type compact torus (CT) acceleration and injection experiment has been carried out using the Himeji Institute of Technology Compact Torus Injector (HIT-CTI). We explore the possibility of refueling, density control, current drive, and edge electric field control of tokamak plasma by means of CT injection. In last September the new HIT-CTI was built up to achieve higher speed (Vct>200 km/s) and higher density CT plasmoid by improving the capacitor bank system and eliminating the impurity and neutral particles. At initial formation discharge tests the gun for formation and compression successfully produced a CT plasmoid and injected it between electrodes for acceleration. (Initial velocity Vct.ini. 32 km/s, Bct 1 kG, Rct=5.5 cm). The formation capacitor bank will be upgraded to two 36 mF capacitors operating at 20 kV (14.4 kJ). The acceleration capacitor bank will be also upgraded to two 36 mF capacitors operating at 20 kV (14.4 kJ). The HIT-CTI will be optimized to obtain suitable CT parameters after acceleration (Bct>5 kG, Lct 20 cm, Vct>200 km/s). In the respect of CT parameter measurement magnetic probes and a He-Ne laser interferometer will be employed in order to measure the CT magnetic field, velocity, density, and length. CT acceleration experimental data on the HIT-CTI and the plan of CT injection experiment on the JFT-2M tokamak (JAERI) will be presented at the meeting.

  14. Sloshing dynamics modulated fluid angular momentum and moment fluctuations driven by orbital gravity gradient and jitter accelerations in microgravity

    NASA Technical Reports Server (NTRS)

    Hung, R. J.; Pan, H. L.

    1995-01-01

    The dynamical behavior of spacecraft propellant affected by the asymmetric combined gravity gradient and jitter accelerations, in particular the effect of surface tension on partially-filled rotating fluids applicable to a full-scale Gravity Probe-B Spacecraft dewar tank has been investigated. Three different cases of orbital accelerations: (1) gravity gradient-dominated, (2) equally weighted between gravity gradient and jitter, and (3) gravity jitter-dominated accelerations are studied. The results of slosh wave excitation along the liquid-vapor interface induced by gravity gradient-dominated accelerations provide a torsional moment with tidal motion of bubble oscillations in the rotating dewar. The results are clearly seen from the twisting shape of the bubble oscillations driven by gravity gradient-dominated acceleration. The results of slosh wave excitation along the liquid-vapor interface induced by gravity jitter-dominated acceleration indicate the results of bubble motion in a manner of down-and-up and leftward-and-rightward movement of oscillation when the bubble is rotating with respect to rotating dewar axis. Fluctuations of angular momentum, fluid moment and bubble mass center caused by slosh wave excitations driven by gravity gradient acceleration or gravity jitter acceleration are also investigated.

  15. Capturing Structural Dynamics in Crystalline Silicon Using Chirped Electrons from a Laser Wakefield Accelerator

    PubMed Central

    He, Z.-H.; Beaurepaire, B.; Nees, J. A.; Gallé, G.; Scott, S. A.; Pérez, J. R. Sánchez; Lagally, M. G.; Krushelnick, K.; Thomas, A. G. R.; Faure, J.

    2016-01-01

    Recent progress in laser wakefield acceleration has led to the emergence of a new generation of electron and X-ray sources that may have enormous benefits for ultrafast science. These novel sources promise to become indispensable tools for the investigation of structural dynamics on the femtosecond time scale, with spatial resolution on the atomic scale. Here, we demonstrate the use of laser-wakefield-accelerated electron bunches for time-resolved electron diffraction measurements of the structural dynamics of single-crystal silicon nano-membranes pumped by an ultrafast laser pulse. In our proof-of-concept study, we resolve the silicon lattice dynamics on a picosecond time scale by deflecting the momentum-time correlated electrons in the diffraction peaks with a static magnetic field to obtain the time-dependent diffraction efficiency. Further improvements may lead to femtosecond temporal resolution, with negligible pump-probe jitter being possible with future laser-wakefield-accelerator ultrafast-electron-diffraction schemes. PMID:27824086

  16. Capturing Structural Dynamics in Crystalline Silicon Using Chirped Electrons from a Laser Wakefield Accelerator

    DOE PAGES

    He, Z. -H.; Beaurepaire, B.; Nees, J. A.; ...

    2016-11-08

    Recent progress in laser wakefield acceleration has led to the emergence of a new generation of electron and X-ray sources that may have enormous benefits for ultrafast science. These novel sources promise to become indispensable tools for the investigation of structural dynamics on the femtosecond time scale, with spatial resolution on the atomic scale. Here in this paper, we demonstrate the use of laser-wakefield-accelerated electron bunches for time-resolved electron diffraction measurements of the structural dynamics of single-crystal silicon nano-membranes pumped by an ultrafast laser pulse. In our proof-of-concept study, we resolve the silicon lattice dynamics on a picosecond time scalemore » by deflecting the momentum-time correlated electrons in the diffraction peaks with a static magnetic field to obtain the time-dependent diffraction efficiency. Further improvements may lead to femtosecond temporal resolution, with negligible pump-probe jitter being possible with future laser-wakefield-accelerator ultrafast-electron-diffraction schemes.« less

  17. Interstellar Mapping and Acceleration Probe (IMAP)

    NASA Astrophysics Data System (ADS)

    Schwadron, N. A.; Opher, M.; Kasper, J.; Mewaldt, R.; Moebius, E.; Spence, H. E.; Zurbuchen, T. H.

    2016-11-01

    particle, and cosmic ray distributions to diagnose the changing space environment and understand the fundamental origins of particle acceleration. This paper, the first citable reference for IMAP, is similar to an unpublished whitepaper that was presented to the National Academies of Sciences, Engineering and Medicine Committee for Solar and Space Physics. We provide the IMAP objectives and instrument straw man traced from the Solar and Space Physics Decadal Survey. It is fitting that our paper is published in the volume of papers that celebrates the 80th birthday of Ed Stone.

  18. Study of the adaptability of existing hardware designs to a Pioneer Saturn/Uranus probe

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The basic concept of designing a scientific entry probe for the expected range of environments at Saturn or Uranus and making the probe compatible with the interface constraints of the Pioneer spacecraft was investigated for launches in the early 1980's. It was found that the amount of hardware commonality between that used in the Pioneer Venus program and that for the Saturn/Uranus probe was approximately 85%. It is recommended that additional development studies be conducted to improve the hardware definitions of the probe design for the following: heat shield, battery, nose cap jettisoning, and thermal control insulation.

  19. Microwave Driven Magnetic Plasma Accelerator Studies (CYCLOPS)

    NASA Technical Reports Server (NTRS)

    Crimi, G. F.; Eckert, A. C.; Miller, D. B.

    1967-01-01

    A microwave-driven cyclotron resonance plasma acceleration device was investigated using argon, krypton, xenon, and mercury as propellants. Limited ranges of propellant flow rate, input power, and magnetic field strength were used. Over-all efficiencies (including the 65% efficiency of the input polarizer) less than 10% were obtained for specific impulse values between 500 and 1500 sec. Power transfer efficiencies, however, approached 100% of the input power available in the right-hand component of the incident circularly polarized radiation. Beam diagnostics using Langmuir probes, cold gas mapping, r-f mapping and ion energy analyses were performed in conjunction with an engine operating in a pulsed mode. Measurements of transverse electron energies at the position of cyclotron resonant absorption yielded energy values more than an order of magnitude lower than anticipated. The measured electron energies were, however, consistent with the low values of average ion energy measured by retarding potential techniques. The low values of average ion energy were also consistent with the measured thrust values. It is hypothesized that ionization and radiation limit the electron kinetic energy to low-values thus limiting the energy which is finally transferred to the ion. Thermalization by electron-electron collision was also identified as an additional loss mechanism. The use of light alkali metals, which have relatively few low lying energy levels to excite, with the input power to mass ratio selected so as to limit the electron energies to less than the second ionization potential, is suggested. It is concluded, however, that the over-all efficiency for such propellants would be less than 40 per cent.

  20. Development of Combustion Tube for Gaseous, Liquid, and Solid Fuels to Study Flame Acceleration and DDT

    NASA Astrophysics Data System (ADS)

    Graziano, Tyler J.

    An experimental combustion tube of 20 ft. in length and 10.25 in. in internal diameter was designed and fabricated in order to perform combustion tests to study deflagration rates, flame acceleration, and the possibility of DDT. The experiment was designed to allow gaseous, liquid, or solid fuels, or any combination of the three to produce a homogenous fuel/air mixture within the tube. Combustion tests were initiated with a hydrogen/oxygen torch igniter and the resulting flame behavior was measured with high frequency ion probes and pressure transducers. Tests were performed with a variety of gaseous and liquid fuels in an unobstructed tube with a closed ignition end and open muzzle. The flame performance with the gaseous fuels is loosely correlated with the expansion ratio, while there is a stronger correlation with the laminar flame speed. The strongest correlation to flame performance is the run-up distance scaling factor. This trend was not observed with the liquid fuels. The reason for this is likely due to incomplete evaporation of the liquid fuel droplets resulting in a partially unburned mixture, effectively altering the intended equivalence ratio. Results suggest that the simple theory for run-up distance and flame acceleration must be modified to more accurately predict the behavior of gaseous fuels. Also, it is likely that more complex spray combustion modeling is required to accurately predict the flame behavior for liquid fuels.

  1. Spectroscopic study of fluorescent probes based on G-quadruplex oligonucleotides labeled with ethynylpyrenyldeoxyuridine.

    PubMed

    Switalska, Angelika; Kierzek, Ryszard; Dembska, Anna; Juskowiak, Bernard

    2017-12-01

    The design, synthesis, and spectral properties of four pyrene labeled oligonucleotide probes with G-quadruplex structure (Tel22-Tpy, Tel22-Upy, Tel22-6Upy, Tel22-18Upy) based on the 22-mer human telomeric sequence (Tel22) have been reported. Pyrene labels in the form of ethynylpyrenyldeoxyuridine have been inserted efficiently into oligodeoxynucleotides probes using phosphoramidite chemistry. The probes exhibited abilities to fold into G-quadruplex structures and to bind metal cations (Na + and K + ). Folding properties of probes and their spectral behavior were examined by recording the UV-vis, fluorescence, and CD spectra as well as by analyzing melting profiles. Fluorescence characteristics and G-quadruplex folding of probes were also studied at the interface of cationic dioctadecyldimethylammonium bromide (DODAB) monolayer. Investigations included film balance measurements (π-A isotherms) and fluorescence spectra recording using a fiber optic accessory interfaced with a spectrofluorimeter. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Probing dimensionality using a simplified 4-probe method.

    PubMed

    Kjeldby, Snorre B; Evenstad, Otto M; Cooil, Simon P; Wells, Justin W

    2017-10-04

    4-probe electrical measurements have been in existence for many decades. One of the most useful aspects of the 4-probe method is that it is not only possible to find the resistivity of a sample (independently of the contact resistances), but that it is also possible to probe the dimensionality of the sample. In theory, this is straightforward to achieve by measuring the 4-probe resistance as a function of probe separation. In practice, it is challenging to move all four probes with sufficient precision over the necessary range. Here, we present an alternative approach. We demonstrate that the dimensionality of the conductive path within a sample can be directly probed using a modified 4-probe method in which an unconventional geometry is exploited; three of the probes are rigidly fixed, and the position of only one probe is changed. This allows 2D and 3D (and other) contributions the to resistivity to be readily disentangled. The required experimental instrumentation can be vastly simplified relative to traditional variable spacing 4-probe instruments.

  3. The time resolved measurement of ultrashort terahertz-band electric fields without an ultrashort probe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walsh, D. A., E-mail: david.walsh@stfc.ac.uk; Snedden, E. W.; Jamison, S. P.

    The time-resolved detection of ultrashort pulsed THz-band electric field temporal profiles without an ultrashort laser probe is demonstrated. A non-linear interaction between a narrow-bandwidth optical probe and the THz pulse transposes the THz spectral intensity and phase information to the optical region, thereby generating an optical pulse whose temporal electric field envelope replicates the temporal profile of the real THz electric field. This optical envelope is characterised via an autocorrelation based FROG (frequency resolved optical gating) measurement, hence revealing the THz temporal profile. The combination of a narrow-bandwidth, long duration, optical probe, and self-referenced FROG makes the technique inherently immunemore » to timing jitter between the optical probe and THz pulse and may find particular application where the THz field is not initially generated via ultrashort laser methods, such as the measurement of longitudinal electron bunch profiles in particle accelerators.« less

  4. Two Step Acceleration Process of Electrons in the Outer Van Allen Radiation Belt by Time Domain Electric Field Bursts and Large Amplitude Chorus Waves

    NASA Astrophysics Data System (ADS)

    Agapitov, O. V.; Mozer, F.; Artemyev, A.; Krasnoselskikh, V.; Lejosne, S.

    2014-12-01

    A huge number of different non-linear structures (double layers, electron holes, non-linear whistlers, etc) have been observed by the electric field experiment on the Van Allen Probes in conjunction with relativistic electron acceleration in the Earth's outer radiation belt. These structures, found as short duration (~0.1 msec) quasi-periodic bursts of electric field in the high time resolution electric field waveform, have been called Time Domain Structures (TDS). They can quite effectively interact with radiation belt electrons. Due to the trapping of electrons into these non-linear structures, they are accelerated up to ~10 keV and their pitch angles are changed, especially for low energies (˜1 keV). Large amplitude electric field perturbations cause non-linear resonant trapping of electrons into the effective potential of the TDS and these electrons are then accelerated in the non-homogeneous magnetic field. These locally accelerated electrons create the "seed population" of several keV electrons that can be accelerated by coherent, large amplitude, upper band whistler waves to MeV energies in this two step acceleration process. All the elements of this chain acceleration mechanism have been observed by the Van Allen Probes.

  5. Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia.

    PubMed

    Atherton, Kathryn E; Filippini, Nicola; Zeman, Adam Z J; Nobre, Anna C; Butler, Christopher R

    2018-05-17

    The accelerated forgetting of newly learned information is common amongst patients with epilepsy and, in particular, in the syndrome of transient epileptic amnesia (TEA). However, the neural mechanisms underlying accelerated forgetting are poorly understood. It has been hypothesised that interictal epileptiform activity during longer retention intervals disrupts normally established memory traces. Here, we tested a distinct hypothesis-that accelerated forgetting relates to the abnormal encoding of memories. We studied a group of 15 patients with TEA together with matched, healthy control subjects. Despite normal performance on standard anterograde memory tasks, patients showed accelerated forgetting of a word list over one week. We used a subsequent memory paradigm to compare encoding-related brain activity in patients and controls. Participants studied a series of visually presented scenes whilst undergoing functional MRI scanning. Recognition memory for these scenes was then probed outside the scanner after delays of 45 min and of 4 days. Patients showed poorer memory for the scenes compared with controls. In the patients but not the controls, subsequently forgotten stimuli were associated with reduced hippocampal activation at encoding. Furthermore, patients demonstrated reduced deactivation of posteromedial cortex regions upon viewing subsequently remembered stimuli as compared to subsequently forgotten ones. These data suggest that abnormal encoding-related activity in key memory areas of the brain contributes to accelerated forgetting in TEA. We propose that abnormally encoded memory traces may be particularly vulnerable to interference from subsequently encountered material and hence be forgotten more rapidly. Our results shed light on the mechanisms underlying memory impairment in epilepsy, and offer support to the proposal that accelerated forgetting may be a useful marker of subtle dysfunction in memory-related brain systems. Copyright © 2018 The

  6. Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Colby, Eric R.; Hogan, Mark J.; /SLAC

    Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As themore » department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.« less

  7. Multifrequency scanning probe microscopy study of nanodiamond agglomerates

    NASA Astrophysics Data System (ADS)

    Aravind, Vasudeva; Lippold, Stephen; Li, Qian; Strelcov, Evgheny; Okatan, Baris; Legum, Benjamin; Kalinin, Sergei; Clarion University Team; Oak Ridge National Laboratory Team

    Due to their rich surface chemistry and excellent mechanical properties and non-toxic nature, nanodiamond particles have found applications such as biomedicine, tribology and lubrication, targeted drug delivery systems, tissue scaffolds and surgical implants. Although single nanodiamond particles have diameters about 4-5nm, they tend to form agglomerates. While these agglomerates can be useful for some purposes, many applications of nanodiamonds require single particle, disaggregated nanodiamonds. This work is oriented towards studying forces and interactions that contribute to agglomeration in nanodiamonds. In this work, using multifrequency scanning probe microscopy techniques, we show that agglomerate sizes can vary between 50-100nm in raw nanodiamonds. Extremeties of particles and Interfaces between agglomerates show dissipative forces with scanning probe microscope tip, indicating agglomerates could act as points of increased adhesion, thus reducing lubricating efficiency when nanodiamonds are used as lubricant additives. This research was conducted at the Center for Nanophase Materials Sciences, which is a DOE Office of Science User Facility.

  8. Recent results of studies of acceleration of compact toroids

    NASA Astrophysics Data System (ADS)

    Hammer, J. H.; Hartmen, C. W.; Eddleman, J.

    1984-03-01

    The observed gross stability and self-contained structure of compact toroids (CT's) give rise to the possibility, unique among magnetically confined plasmas, of translating CT's from their point of origin over distances many times their own length. This feature has led us to consider magnetic acceleration of CT's to directed kinetic energies much greater than their stored magnetic and thermal energies. A CT accelerator falls in the very broad gap between traditional particle accelerators at one extreme, which are limited in the number of particles per bunch by electrostatic repulsive forces, and mass accelerators such as rail guns at the other extreme, which accelerate many particles but are forced by the stress limitations of solids to far smaller accelerations. A typical CT has about a Coulomb of particles, weighs 10 micrograms and can be accelerated by magnetic forces of several tons, leading to an acceleration on the order of 10(11) gravities.

  9. Evidence for the Stochastic Acceleration of Secondary Antiprotons by Supernova Remnants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cholis, Ilias; Hooper, Dan; Linden, Tim

    2017-01-16

    The antiproton-to-proton ratio in the cosmic-ray spectrum is a sensitive probe of new physics. Using recent measurements of the cosmic-ray antiproton and proton fluxes in the energy range of 1-1000 GeV, we study the contribution to themore » $$\\bar{p}/p$$ ratio from secondary antiprotons that are produced and subsequently accelerated within individual supernova remnants. We consider several well-motivated models for cosmic-ray propagation in the interstellar medium and marginalize our results over the uncertainties related to the antiproton production cross section and the time-, charge-, and energy-dependent effects of solar modulation. We find that the increase in the $$\\bar{p}/p$$ ratio observed at rigidities above $$\\sim$$ 100 GV cannot be accounted for within the context of conventional cosmic-ray propagation models, but is consistent with scenarios in which cosmic-ray antiprotons are produced and subsequently accelerated by shocks within a given supernova remnant. In light of this, the acceleration of secondary cosmic rays in supernova remnants is predicted to substantially contribute to the cosmic-ray positron spectrum, accounting for a significant fraction of the observed positron excess.« less

  10. Comparative testing of pulse oximeter probes.

    PubMed

    van Oostrom, Johannes H; Melker, Richard J

    2004-05-01

    The testing of pulse oximeter probes is generally limited to the integrity of the electrical circuit and does not include the optical properties of the probes. Few pulse oximeter testers evaluate the accuracy of both the monitor and the probe. We designed a study to compare the accuracy of nonproprietary probes (OSS Medical) designed for use with Nellcor, Datex-Ohmeda, and Criticare pulse oximeter monitors with that of their corresponding proprietary probes by using a commercial off-the-shelf pulse oximeter tester (Index). The Index pulse oximeter tester does include testing of the optical properties of the pulse oximeter probes. The pulse oximeter tester was given a controlled input that simulated acute apnea. Desaturation curves were automatically recorded from the pulse oximeter monitors with a data-collection computer. Comparisons between equivalent proprietary and nonproprietary probes were performed. Data were analyzed by using univariate and multivariate general linear model analysis. Five OSS Medical probe models were statistically better than the equivalent proprietary probes. The remainder of the probes were statistically similar. Comparative and simulation studies can have significant advantages over human studies because they are cost-effective, evaluate equipment in a clinically relevant scenario, and pose no risk to patients, but they are limited by the realism of the simulation. We studied the performance of pulse oximeter probes in a simulated environment. Our results show significant differences between some probes that affect the accuracy of measurement.

  11. Ten bar probe technical summary. [feasibility of outer planet common atmospheric probe

    NASA Technical Reports Server (NTRS)

    Ellis, T. R.

    1974-01-01

    The feasibility of an outer planet common atmospheric probe is studied with emphasis on entry heating rates and improved ephemeris. It is concluded that a common probe design is possible except for Jupiter; the basic technology exists except for Jupiter heat shielding. A Mariner class bus provides for better bus science and probe bus communications than a Pioneer class bus.

  12. Physics Program at COSY-Juelich with Polarized Hadronic Probes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kacharava, Andro

    2009-08-04

    Hadron physics aims at a fundamental understanding of all particles and their interactions that are subject to the strong force. Experiments using hadronic probes could contribute to shed light on open questions on the structure of hadrons and their interaction as well as the symmetries of nature. The COoler SYnchrotron COSY at the Forschungszentrum Juelich accelerates protons and deuterons with momenta up to 3.7 GeV/c. The availability of both an electron cooler as well as a stochastic beam cooling system allows for precision measurements, using polarized proton and deuteron beams in combination with polarized Hydrogen or Deuterium targets.This contribution summarizesmore » the ongoing physics program at the COSY facility using ANKE, WASA and TOF detector systems with polarized hadronic probes, highlighting recent results and outlining the new developments.« less

  13. Social-emotional characteristics of gifted accelerated and non-accelerated students in the Netherlands.

    PubMed

    Hoogeveen, Lianne; van Hell, Janet G; Verhoeven, Ludo

    2012-12-01

    In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. In this study, social-emotional characteristics of accelerated gifted students in the Netherlands were examined in relation to personal and environmental factors. Self-concept and social contacts of accelerated (n = 148) and non-accelerated (n = 55) gifted students, aged 4 to 27 (M = 11.22, SD = 4.27) were measured. Self-concept and social contacts of accelerated and non-accelerated gifted students were measured using a questionnaire and a diary, and parents of these students evaluated their behavioural characteristics. Gender and birth order were studied as personal factors and grade, classroom, teachers' gender, teaching experience, and the quality of parent-school contact as environmental factors. The results showed minimal differences in the social-emotional characteristics of accelerated and non-accelerated gifted students. The few differences we found favoured the accelerated students. We also found that multiple grade skipping does not have negative effects on social-emotional characteristics, and that long-term effects of acceleration tend to be positive. As regards the possible modulation of personal and environmental factors, we merely found an impact of such factors in the non-accelerated group. The results of this study strongly suggest that social-emotional characteristics of accelerated gifted students and non-accelerated gifted students are largely similar. These results thus do not support worries expressed by teachers about the acceleration of gifted students. Our findings parallel the outcomes of earlier studies in the United States and Germany in that we observed that acceleration does not harm gifted students, not even in the case of multiple grade skipping. On the contrary, there is a

  14. Probing ultra-fast processes with high dynamic range at 4th-generation light sources: Arrival time and intensity binning at unprecedented repetition rates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovalev, S.; Green, B.; Golz, T.

    Here, understanding dynamics on ultrafast timescales enables unique and new insights into important processes in the materials and life sciences. In this respect, the fundamental pump-probe approach based on ultra-short photon pulses aims at the creation of stroboscopic movies. Performing such experiments at one of the many recently established accelerator-based 4th-generation light sources such as free-electron lasers or superradiant THz sources allows an enormous widening of the accessible parameter space for the excitation and/or probing light pulses. Compared to table-top devices, critical issues of this type of experiment are fluctuations of the timing between the accelerator and external laser systemsmore » and intensity instabilities of the accelerator-based photon sources. Existing solutions have so far been only demonstrated at low repetition rates and/or achieved a limited dynamic range in comparison to table-top experiments, while the 4th generation of accelerator-based light sources is based on superconducting radio-frequency technology, which enables operation at MHz or even GHz repetition rates. In this article, we present the successful demonstration of ultra-fast accelerator-laser pump-probe experiments performed at an unprecedentedly high repetition rate in the few-hundred-kHz regime and with a currently achievable optimal time resolution of 13 fs (rms). Our scheme, based on the pulse-resolved detection of multiple beam parameters relevant for the experiment, allows us to achieve an excellent sensitivity in real-world ultra-fast experiments, as demonstrated for the example of THz-field-driven coherent spin precession.« less

  15. Probing ultra-fast processes with high dynamic range at 4th-generation light sources: Arrival time and intensity binning at unprecedented repetition rates.

    PubMed

    Kovalev, S; Green, B; Golz, T; Maehrlein, S; Stojanovic, N; Fisher, A S; Kampfrath, T; Gensch, M

    2017-03-01

    Understanding dynamics on ultrafast timescales enables unique and new insights into important processes in the materials and life sciences. In this respect, the fundamental pump-probe approach based on ultra-short photon pulses aims at the creation of stroboscopic movies. Performing such experiments at one of the many recently established accelerator-based 4th-generation light sources such as free-electron lasers or superradiant THz sources allows an enormous widening of the accessible parameter space for the excitation and/or probing light pulses. Compared to table-top devices, critical issues of this type of experiment are fluctuations of the timing between the accelerator and external laser systems and intensity instabilities of the accelerator-based photon sources. Existing solutions have so far been only demonstrated at low repetition rates and/or achieved a limited dynamic range in comparison to table-top experiments, while the 4th generation of accelerator-based light sources is based on superconducting radio-frequency technology, which enables operation at MHz or even GHz repetition rates. In this article, we present the successful demonstration of ultra-fast accelerator-laser pump-probe experiments performed at an unprecedentedly high repetition rate in the few-hundred-kHz regime and with a currently achievable optimal time resolution of 13 fs (rms). Our scheme, based on the pulse-resolved detection of multiple beam parameters relevant for the experiment, allows us to achieve an excellent sensitivity in real-world ultra-fast experiments, as demonstrated for the example of THz-field-driven coherent spin precession.

  16. Probing ultra-fast processes with high dynamic range at 4th-generation light sources: Arrival time and intensity binning at unprecedented repetition rates

    DOE PAGES

    Kovalev, S.; Green, B.; Golz, T.; ...

    2017-03-06

    Here, understanding dynamics on ultrafast timescales enables unique and new insights into important processes in the materials and life sciences. In this respect, the fundamental pump-probe approach based on ultra-short photon pulses aims at the creation of stroboscopic movies. Performing such experiments at one of the many recently established accelerator-based 4th-generation light sources such as free-electron lasers or superradiant THz sources allows an enormous widening of the accessible parameter space for the excitation and/or probing light pulses. Compared to table-top devices, critical issues of this type of experiment are fluctuations of the timing between the accelerator and external laser systemsmore » and intensity instabilities of the accelerator-based photon sources. Existing solutions have so far been only demonstrated at low repetition rates and/or achieved a limited dynamic range in comparison to table-top experiments, while the 4th generation of accelerator-based light sources is based on superconducting radio-frequency technology, which enables operation at MHz or even GHz repetition rates. In this article, we present the successful demonstration of ultra-fast accelerator-laser pump-probe experiments performed at an unprecedentedly high repetition rate in the few-hundred-kHz regime and with a currently achievable optimal time resolution of 13 fs (rms). Our scheme, based on the pulse-resolved detection of multiple beam parameters relevant for the experiment, allows us to achieve an excellent sensitivity in real-world ultra-fast experiments, as demonstrated for the example of THz-field-driven coherent spin precession.« less

  17. Correction of static pressure on a research aircraft in accelerated flight using differential pressure measurements

    NASA Astrophysics Data System (ADS)

    Rodi, A. R.; Leon, D. C.

    2012-05-01

    Geometric altitude data from a combined Global Navigation Satellite System (GNSS) and inertial measurement unit (IMU) system on the University of Wyoming King Air research aircraft are used to estimate acceleration effects on static pressure measurement. Using data collected during periods of accelerated flight, comparison of measured pressure with that derived from GNSS/IMU geometric altitude show that errors exceeding 150 Pa can occur which is significant in airspeed and atmospheric air motion determination. A method is developed to predict static pressure errors from analysis of differential pressure measurements from a Rosemount model 858 differential pressure air velocity probe. The method was evaluated with a carefully designed probe towed on connecting tubing behind the aircraft - a "trailing cone" - in steady flight, and shown to have a precision of about ±10 Pa over a wide range of conditions including various altitudes, power settings, and gear and flap extensions. Under accelerated flight conditions, compared to the GNSS/IMU data, this algorithm predicts corrections to a precision of better than ±20 Pa. Some limiting factors affecting the precision of static pressure measurement on a research aircraft are examined.

  18. Field stabilization studies for a radio frequency quadrupole accelerator

    NASA Astrophysics Data System (ADS)

    Gaur, R.; Kumar, V.

    2014-07-01

    The Radio Frequency Quadrupole (RFQ) linear accelerator is an accelerator that efficiently focuses, bunches and accelerates a high intensity DC beam from an ion source, for various applications. Unlike other conventional RF linear accelerators, the electromagnetic mode used for its operation is not the lowest frequency mode supported by the structure. In a four vane type RFQ, there are several undesired electromagnetic modes having frequency close to that of the operating mode. While designing an RFQ accelerator, care must be taken to ensure that the frequencies of these nearby modes are sufficiently separated from the operating mode. If the undesired nearby modes have frequencies close to the operating mode, the electromagnetic field pattern in the presence of geometrical errors will not be stabilized to the desired field profile, and will be perturbed by the nearby modes. This will affect the beam dynamics and reduce the beam transmission. In this paper, we present a detailed study of the electromagnetic modes supported, which is followed by calculations for implementation of suitable techniques to make the desired operating mode stable against mixing with unwanted modes for an RFQ being designed for the proposed Indian Spallation Neutron Source (ISNS) project at Raja Ramanna Centre for Advanced Technology, Indore. Resonant coupling scheme, along with dipole stabilization rods has been proposed to increase the mode separation. The paper discusses the details of a generalized optimization procedure that has been used for the design of mode stabilization scheme.

  19. Ground Motion Studies for Large Future Accelerator

    NASA Astrophysics Data System (ADS)

    Takeda, Shigeru; Oide, Katsunobu

    1997-05-01

    The future large accelerator, such as TeV linear collider, should have extremely small emittance to perform the required luminosity. Precise alignment of machine components is essential to prevent emittance dilution. The ground motion spoils alignment of accelerator elements and results in emittance growth. The ground motion in the frequency range of seismic vibration is mostly coherent in the related accelerator. But the incoherent diffusive or Brownian like motion becomes dominant at frequency region less than seismic vibration [1, 2, 3]. Slow ground motion with respect to the machine performance is discussed including the method of tunnel construction. Our experimental results and recent excavated results clarify that application of TBMs is better excavating method than NATM (Drill + Blast) for accelerator tunnel to prevent emittance dilution. ([1] V. Shiltsev, Proc. of IWAA95 Tsukuba, 1995. [2] Shigeru Takeda et al., Proc. of EPAC96, 1996. [3] A. Sery, Proc. of LINAC96, 1996.)

  20. EDITORIAL: Laser and plasma accelerators Laser and plasma accelerators

    NASA Astrophysics Data System (ADS)

    Bingham, Robert

    2009-02-01

    This special issue on laser and plasma accelerators illustrates the rapid advancement and diverse applications of laser and plasma accelerators. Plasma is an attractive medium for particle acceleration because of the high electric field it can sustain, with studies of acceleration processes remaining one of the most important areas of research in both laboratory and astrophysical plasmas. The rapid advance in laser and accelerator technology has led to the development of terawatt and petawatt laser systems with ultra-high intensities and short sub-picosecond pulses, which are used to generate wakefields in plasma. Recent successes include the demonstration by several groups in 2004 of quasi-monoenergetic electron beams by wakefields in the bubble regime with the GeV energy barrier being reached in 2006, and the energy doubling of the SLAC high-energy electron beam from 42 to 85 GeV. The electron beams generated by the laser plasma driven wakefields have good spatial quality with energies ranging from MeV to GeV. A unique feature is that they are ultra-short bunches with simulations showing that they can be as short as a few femtoseconds with low-energy spread, making these beams ideal for a variety of applications ranging from novel high-brightness radiation sources for medicine, material science and ultrafast time-resolved radiobiology or chemistry. Laser driven ion acceleration experiments have also made significant advances over the last few years with applications in laser fusion, nuclear physics and medicine. Attention is focused on the possibility of producing quasi-mono-energetic ions with energies ranging from hundreds of MeV to GeV per nucleon. New acceleration mechanisms are being studied, including ion acceleration from ultra-thin foils and direct laser acceleration. The application of wakefields or beat waves in other areas of science such as astrophysics and particle physics is beginning to take off, such as the study of cosmic accelerators considered

  1. Accuracy of probing attachment levels using a new computerized cemento-enamel junction probe.

    PubMed

    Deepa, R; Prakash, Shobha

    2012-01-01

    The assessment of clinical attachment level (CAL) represents the gold standard for diagnosing and monitoring periodontal disease. The aim of the present study was to evaluate the performance of the newly introduced cemento-enamel junction (CEJ) probe in detecting CAL, using CEJ as a fixed reference point, and to compare the CEJ probe with the Florida stent probe (FSP) as well as with a standard manual probe, University of North Carolina-15 (UNC-15). Three examiners recorded the probing attachment level in 384 sites in case group (chronic periodontitis), and in 176 sites, in control group (healthy periodontal status), using the three probes. Subjects included both the sexes and ranged from 35 to 45 years. The experimental design was structured to balance the intra- and inter-examiner consistency at the same site during the two visits. CEJ probe showed higher intra-and inter-examiner consistency over both FSP and UNC-15 in both the case and control groups. Frequency distribution of differences of various magnitudes of repeated measurements ≤1 mm was in the higher range of 86.8% to 87.5% for CEJ probe. The FSP was more reproducible than UNC-15 in detecting relative attachment level (RAL). CEJ automated probe was found to have greatest potential for accuracy and consistency in detecting CAL than FSP and UNC-15. The automated probes appeared to be more reproducible than manual probes.

  2. New Signal Amplification Strategy Using Semicarbazide as Co-reaction Accelerator for Highly Sensitive Electrochemiluminescent Aptasensor Construction.

    PubMed

    Ma, Meng-Nan; Zhuo, Ying; Yuan, Ruo; Chai, Ya-Qin

    2015-11-17

    A highly sensitive electrochemiluminescent (ECL) aptasensor was constructed using semicarbazide (Sem) as co-reaction accelerator to promote the ECL reaction rate of CdTe quantum dots (CdTe QDs) and the co-reactant of peroxydisulfate (S2O8(2-)) for boosting signal amplification. The co-reaction accelerator is a species that when it is introduced into the ECL system containing luminophore and co-reactant, it can interact with co-reactant rather than luminophore to promote the ECL reaction rate of luminophore and co-reactant; thus the ECL signal is significantly amplified in comparison with that in which only luminophore and co-reactant are present. In this work, the ECL signal probes were first fabricated by alternately assembling the Sem and Au nanoparticles (AuNPs) onto the surfaces of hollow Au nanocages (AuNCs) via Au-N bond to obtain the multilayered nanomaterials of (AuNPs-Sem)n-AuNCs for immobilizing amino-terminated detection aptamer of thrombin (TBA2). Notably, the Sem with two -NH2 terminal groups could not only serve as cross-linking reagent to assemble AuNPs and AuNCs but also act as co-reaction accelerator to enhance the ECL reaction rate of CdTe QDs and S2O8(2-) for signal amplification. With the sandwich-type format, TBA2 signal probes could be trapped on the CdTe QD-based sensing interface in the presence of thrombin (TB) to achieve a considerably enhanced ECL signal in S2O8(2-) solution. As a result, the Sem in the TBA2 signal probes could accelerate the reduction of S2O8(2-) to produce the more oxidant mediators of SO4(•-), which further boosted the production of excited states of CdTe QDs to emit light. With the employment of the novel co-reaction accelerator Sem, the proposed ECL biosensor exhibited ultrahigh sensitivity to quantify the concentration of TB from 1 × 10(-7) to 1 nM with a detection limit of 0.03 fM, which demonstrated that the co-reaction accelerator could provide a simple, efficient, and low-cost approach for signal

  3. Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies.

    PubMed

    Ayub, Suleman; Gentet, Luc J; Fiáth, Richárd; Schwaerzle, Michael; Borel, Mélodie; David, François; Barthó, Péter; Ulbert, István; Paul, Oliver; Ruther, Patrick

    2017-09-01

    This article reports on the development, i.e., the design, fabrication, and validation of an implantable optical neural probes designed for in vivo experiments relying on optogenetics. The probes comprise an array of ten bare light-emitting diode (LED) chips emitting at a wavelength of 460 nm and integrated along a flexible polyimide-based substrate stiffened using a micromachined ladder-like silicon structure. The resulting mechanical stiffness of the slender, 250-μm-wide, 65-μm-thick, and 5- and 8-mm-long probe shank facilitates its implantation into neural tissue. The LEDs are encapsulated by a fluropolymer coating protecting the implant against the physiological conditions in the brain. The electrical interface to the external control unit is provided by 10-μm-thick, highly flexible polyimide cables making the probes suitable for both acute and chronic in vivo experiments. Optical and electrical properties of the probes are reported, as well as their in vivo validation in acute optogenetic studies in transgenic mice. The depth-dependent optical stimulation of both excitatory and inhibitory neurons is demonstrated by altering the brain activity in the cortex and the thalamus. Local network responses elicited by 20-ms-long light pulses of different optical power (20 μW and 1 mW), as well as local modulation of single unit neuronal activity to 1-s-long light pulses with low optical intensity (17 μW) are presented. The ability to modulate neural activity makes these devices suitable for a broad variety of optogenetic experiments.

  4. Titan probe technology assessment and technology development plan study

    NASA Technical Reports Server (NTRS)

    Castro, A. J.

    1980-01-01

    The need for technology advances to accomplish the Titan probe mission was determined by defining mission conditions and requirements and evaluating the technology impact on the baseline probe configuration. Mission characteristics found to be technology drivers include (1) ten years dormant life in space vacuum; (2) unknown surface conditions, various sample materials, and a surface temperature; and (3) mission constraints of the Saturn Orbiter Dual Probe mission regarding weight allocation. The following areas were identified for further development: surface sample acquisition system; battery powered system; nonmetallic materials; magnetic bubble memory devices, and the landing system. Preentry science, reliability, and weight reduction and redundancy must also be considered.

  5. Self-mapping the longitudinal field structure of a nonlinear plasma accelerator cavity

    DOE PAGES

    Clayton, C. E.; Adli, E.; Allen, J.; ...

    2016-08-16

    The preservation of emittance of the accelerating beam is the next challenge for plasma-based accelerators envisioned for future light sources and colliders. The field structure of a highly nonlinear plasma wake is potentially suitable for this purpose but has not been yet measured. Here we show that the longitudinal variation of the fields in a nonlinear plasma wakefield accelerator cavity produced by a relativistic electron bunch can be mapped using the bunch itself as a probe. We find that, for much of the cavity that is devoid of plasma electrons, the transverse force is constant longitudinally to within ±3% (r.m.s.).more » Moreover, comparison of experimental data and simulations has resulted in mapping of the longitudinal electric field of the unloaded wake up to 83 GV m –1 to a similar degree of accuracy. Lastly, these results bode well for high-gradient, high-efficiency acceleration of electron bunches while preserving their emittance in such a cavity.« less

  6. Self-mapping the longitudinal field structure of a nonlinear plasma accelerator cavity

    PubMed Central

    Clayton, C. E.; Adli, E.; Allen, J.; An, W.; Clarke, C. I.; Corde, S.; Frederico, J.; Gessner, S.; Green, S. Z.; Hogan, M. J.; Joshi, C.; Litos, M.; Lu, W.; Marsh, K. A.; Mori, W. B.; Vafaei-Najafabadi, N.; Xu, X.; Yakimenko, V.

    2016-01-01

    The preservation of emittance of the accelerating beam is the next challenge for plasma-based accelerators envisioned for future light sources and colliders. The field structure of a highly nonlinear plasma wake is potentially suitable for this purpose but has not been yet measured. Here we show that the longitudinal variation of the fields in a nonlinear plasma wakefield accelerator cavity produced by a relativistic electron bunch can be mapped using the bunch itself as a probe. We find that, for much of the cavity that is devoid of plasma electrons, the transverse force is constant longitudinally to within ±3% (r.m.s.). Moreover, comparison of experimental data and simulations has resulted in mapping of the longitudinal electric field of the unloaded wake up to 83 GV m−1 to a similar degree of accuracy. These results bode well for high-gradient, high-efficiency acceleration of electron bunches while preserving their emittance in such a cavity. PMID:27527569

  7. Preparation and quality test of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide probe: a preliminary study.

    PubMed

    Wen, Ming; Li, Bibo; Ouyang, Yu; Luo, Yi; Li, Shaolin

    2009-06-01

    Molecular imaging of tumor antisense gene techniques have been applied to the study of magnetic resonance (MR) gene imaging associated with malignant tumors. In this study, we designed, synthesized, and tested a novel molecular probe, in which the antisense oligodeoxynucleotide (ASODN) was labeled with superparamagnetic iron oxide (SPIO), and its efficiency was examined by in vitro MR imaging after SK-Br-3 mammary carcinoma cell lines (oncocytes) transfection. The SPIO-labeled ASODN probe was prepared through SPIO conjugated to ASODN using a chemical cross linking method. Its morphology and size were detected by atomic force microscope, size distribution were detected by laser granulometer, the conjugating rate and biological activity were determined by high performance liquid chromatography, and the stability was determined by polyacrylamide gel electrophoresis. After that, the probes were transfected into the SK-Br-3 oncocytes, cellular iron uptake was analyzed qualitatively at light and electron microscopy and was quantified at atomic absorption spectrometry, and the signal change of the transfected cells was observed and measured using MR imaging. The morphology of the SPIO-labeled ASODN probe was mostly spherical with well-distributed scattering, and the diameters were between 25 and 40 nm (95%) by atomic force microscope and laser granulometer, the conjugating rate of the probe was 99%. Moreover, this probe kept its activity under physiological conditions and could conjugate with antisense oligodeoxynucleotide. In addition, light microscopy revealed an intracellular uptake of iron oxides in the cytosol and electron microscopic studies revealed a lysosomal deposition of iron oxides in the transfected SK-Br-3 oncocytes by antisense probes, some of them gathered stacks, and the iron content of the group of transfected SK-Br-3 oncocytes by antisense probe is significantly higher (18.37 +/- 0.42 pg) than other contrast groups, the MR imaging showed that

  8. Heavy ion linear accelerator for radiation damage studies of materials

    NASA Astrophysics Data System (ADS)

    Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.; Nolen, Jerry; Barcikowski, Albert; Pellin, Michael; Yacout, Abdellatif

    2017-03-01

    A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response of the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for 238U50+ and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.

  9. Heavy ion linear accelerator for radiation damage studies of materials

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.

    A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response ofmore » the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for U-238(50+) and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.« less

  10. Applications of DNA-Stable Isotope Probing in Bioremediation Studies

    NASA Astrophysics Data System (ADS)

    Chen, Yin; Vohra, Jyotsna; Murrell, J. Colin

    DNA-stable isotope probing, a method to identify active microorganisms without the prerequisite of cultivation, has been widely applied in the study of microorganisms involved in the degradation of environmental pollutants. Recent advances and technique considerations in applying DNA-SIP in bioremediation are highlighted. A detailed protocol of a DNA-SIP experiment is provided.

  11. Applications of DNA-stable isotope probing in bioremediation studies.

    PubMed

    Chen, Yin; Vohra, Jyotsna; Murrell, J Colin

    2010-01-01

    DNA-stable isotope probing, a method to identify active microorganisms without the prerequisite of cultivation, has been widely applied in the study of microorganisms involved in the degradation of environmental pollutants. Recent advances and technique considerations in applying DNA-SIP in bioremediation are highlighted. A detailed protocol of a DNA-SIP experiment is provided.

  12. Study of Car Acceleration and Deceleration Characteristics at Dangerous Route FT050

    NASA Astrophysics Data System (ADS)

    Omar, N.; Prasetijo, J.; Daniel, B. D.; Abdullah, M. A. E.; Ismail, I.

    2018-04-01

    Individual vehicle acceleration and deceleration are important to generate vehicles speed profile. This study covered acceleration and deceleration characteristics of passenger car in Federal Route FT050 Jalan Batu Pahat-Ayer Hitam that was the top ranking dangerous road. Global Positioning System was used to record 10 cars speed to develop speed profile with clustering zone. At the acceleration manoeuver, the acceleration rate becomes lower as the drivers get near to desired speed. While, at deceleration manoeuver, vehicles with high speed needs more time to stop compare to low speed vehicle. This is because, the drivers need to accelerate more from zero speed to achieve desired speed and drivers need more distance and time to stop their vehicles. However, it was found out that 30% to 50% are driving in dangerous condition that was proven in clustering acceleration and deceleration speed profile. As conclusion, this excessive drivers are the factor that creating high risk in rear-end collision that inline FT050 as dangerous road in Malaysia

  13. Accelerated stability studies of Sufoofe Sailan: A Unani formulation.

    PubMed

    Rani, Seema; Rahman, Khaleequr; Younis, Peerzada Mohammad

    2015-01-01

    Sufoofe Sailan (SS) is a polyherbal powder preparation used in Unani medicine to treat gynecological diseases. It is observed that SS degrade early as it is in the form of powder; however, the stability study of SS was not carried out till date. To evaluate the accelerated stability of SS. Finished formulation of SS was packed in three airtight transparent polyethylene terephthalate containers. One pack was analyzed just after manufacturing and remaining two packs were kept in stability chamber at 40°C ± 2°C/75% ± 5% RH, of which one pack was analyzed after the completion of three and another after 6 months. Organoleptic, physico-chemical, microbiological parameters along with high-performance thin layer chromatography (HPTLC) fingerprinting were carried out. Organoleptic characters showed no significant change in accelerated stability condition. All physico-chemical parameters showed changes <5%, HPTLC fingerprinting showed minimum changes and microbial studies were in confirmation to the World Health Organization guidelines. SS confirmed to the International Conference on Harmonization Guideline for accelerated testing of the pharmaceutical product on said parameters and as per the Grimm's statement the shelf life of SS may last 20 months.

  14. ACCELERATION AND ENRICHMENT IN THE JUNIOR HIGH SCHOOL. A FOLLOW-UP STUDY.

    ERIC Educational Resources Information Center

    ARENDS, RICHARD H.; FORD, PAUL M.

    THE 1963-64 STUDY INVOLVED AN INVESTIGATION OF ACCELERATION IN MATHEMATICS AND ENRICHMENT IN READING AND SCIENCE IN THE JUNIOR HIGH SCHOOL. BUT THE RESEARCH WAS BROADENED AND, UNLIKE THE 1962-63 STUDY, EXPLORED MORE DEEPLY THE EFFECTS OF ACCELERATION AND ENRICHMENT. A NUMBER OF SCHOOLS OUTSIDE OF WALLA WALLA WAS USED. PROBLEMS CONSIDERED WERE--(1)…

  15. Large Observatory for X-ray Timing (LOFT-P): A Probe-Class Mission Concept Study

    NASA Technical Reports Server (NTRS)

    Wilson-Hodge, Colleen A.; Ray, P. S.; Chakrabarty, D.; Feroci, M.; Jenke, Peter; Griffith, C.; Zane, S.; Winter, B.; Brandt, S.; Hernamdez, M.; hide

    2016-01-01

    LOFT-P is a mission concept for a NASA Astrophysics Probe-Class (less than $1B) X-ray timing mission, based on the LOFT M-class concept originally proposed to ESA's M3 and M4 calls. LOFT-P requires very large collecting area, high time resolution, good spectral resolution, broadband spectral coverage (2-30 keV), highly flexible scheduling, and an ability to detect and respond promptly to time-critical targets of opportunity. Many of LOFTP's targets are bright, rapidly varying sources, so these measurements are synergistic to imaging and high-resolution spectroscopy instruments, addressing much smaller distance scales than are possible without very long baseline X-ray interferometry, and using complementary techniques to address the geometry and dynamics of emission regions. LOFT-P was presented as an example mission to the head of NASA's Astrophysics Division, to demonstrate the strong community support for creation of a probe-class, for missions costing between $500M and $1B. We submitted a white paper4 in response to NASA PhysPAG's call for white papers: Probe-class Mission Concepts, describing LOFT-P science and a simple extrapolation from the ESA study costs. The next step for probe-class missions will be input into the NASA Astrophysics Decadal Survey to encourage the creation of a probe-class opportunity. We report on a 2016 study by MSFC's Advanced Concepts Office of LOFT-P, a US-led probe-class LOFT concept.

  16. Atom Probe Tomography Studies on the Cu(In,Ga)Se2 Grain Boundaries

    PubMed Central

    Cojocaru-Mirédin, Oana; Schwarz, Torsten; Choi, Pyuck-Pa; Herbig, Michael; Wuerz, Roland; Raabe, Dierk

    2013-01-01

    Compared with the existent techniques, atom probe tomography is a unique technique able to chemically characterize the internal interfaces at the nanoscale and in three dimensions. Indeed, APT possesses high sensitivity (in the order of ppm) and high spatial resolution (sub nm). Considerable efforts were done here to prepare an APT tip which contains the desired grain boundary with a known structure. Indeed, site-specific sample preparation using combined focused-ion-beam, electron backscatter diffraction, and transmission electron microscopy is presented in this work. This method allows selected grain boundaries with a known structure and location in Cu(In,Ga)Se2 thin-films to be studied by atom probe tomography. Finally, we discuss the advantages and drawbacks of using the atom probe tomography technique to study the grain boundaries in Cu(In,Ga)Se2 thin-film solar cells. PMID:23629452

  17. Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling.

    PubMed

    Takano, Yoko; Echizen, Honami; Hanaoka, Kenjiro

    2017-10-01

    Hydrogen sulfide (H 2 S) plays roles in many physiological processes, including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition of insulin signaling, and regulation of inflammation. Also, hydropersulfide (R-S-SH) and polysulfide (-S-S n -S-) have recently been identified as reactive sulfur species (RSS) that regulate the bioactivities of multiple proteins via S-sulfhydration of cysteine residues (protein Cys-SSH) and show cytoprotection. Chemical tools such as fluorescent probes and selective inhibitors are needed to establish in detail the physiological roles of H 2 S and polysulfide. Recent Advances: Although many fluorescent probes for H 2 S are available, fluorescent probes for hydropersulfide and polysulfide have only recently been developed and used to detect these sulfur species in living cells. In this review, we summarize recent progress in developing chemical tools for the study of H 2 S, hydropersulfide, and polysulfide, covering fluorescent probes based on various design strategies and selective inhibitors of H 2 S- and polysulfide-producing enzymes (cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase), and we summarize their applications in biological studies. Despite recent progress, the precise biological functions of H 2 S, hydropersulfide, and polysulfide remain to be fully established. Fluorescent probes and selective inhibitors are effective chemical tools to study the physiological roles of these sulfur molecules in living cells and tissues. Therefore, further development of a broad range of practical fluorescent probes and selective inhibitors as tools for studies of RSS biology is currently attracting great interest. Antioxid. Redox Signal. 27, 669-683.

  18. Study on acceleration processes of the radiation belt electrons through interaction with sub-packet chorus waves in parallel propagation

    NASA Astrophysics Data System (ADS)

    Hiraga, R.; Omura, Y.

    2017-12-01

    By recent observations, chorus waves include fine structures such as amplitude fluctuations (i.e. sub-packet structure), and it has not been verified in detail yet how energetic electrons are efficiently accelerated under the wave features. In this study, we firstly focus on the acceleration process of a single electron: how it experiences the efficient energy increase by interaction with sub-packet chorus waves in parallel propagation along the Earth's magnetic field. In order to reproduce the chorus waves as seen by the latest observations by Van Allen Probes (Foster et al. 2017), the wave model amplitude in our simulation is structured such that when the wave amplitude nonlinearly grows to reach the optimum amplitude, it starts decreasing until crossing the threshold. Once it crosses the threshold, the wave dissipates and a new wave rises to repeat the nonlinear growth and damping in the same manner. The multiple occurrence of this growth-damping cycle forms a saw tooth-like amplitude variation called sub-packet. This amplitude variation also affects the wave frequency behavior which is derived by the chorus wave equations as a function of the wave amplitude (Omura et al. 2009). It is also reasonable to assume that when a wave packet diminishes and the next wave rises, it has a random phase independent of the previous wave. This randomness (discontinuity) in phase variation is included in the simulation. Through interaction with such waves, dynamics of energetic electrons were tracked. As a result, some electrons underwent an efficient acceleration process defined as successive entrapping, in which an electron successfully continues to surf the trapping potential generated by consecutive wave packets. When successive entrapping occurs, an electron trapped and de-trapped (escape the trapping potential) by a single wave packet falls into another trapping potential generated by the next wave sub-packet and continuously accelerated. The occurrence of successive

  19. Designing a sun-pointing Faraday cup for solar probe plus

    NASA Astrophysics Data System (ADS)

    Case, A. W.; Kasper, J. C.; Daigneau, P. S.; Caldwell, D.; Freeman, M.; Gauron, T.; Maruca, B. A.; Bookbinder, J.; Korreck, K. E.; Cirtain, J. W.; Effinger, M. E.; Halekas, J. S.; Larson, D. E.; Lazarus, A. J.; Stevens, M. L.; Taylor, E. R.; Wright, K. H., Jr.

    2013-06-01

    The NASA Solar Probe Plus (SPP) mission will be the first spacecraft to pass through the sub-Alfvénic solar corona. The objectives of the mission are to trace the flow of energy that heats and accelerates the solar corona and solar wind, to determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind, and to explore mechanisms that accelerate and transport energetic particles. The Solar Wind Electrons, Alphas, and Protons (SWEAP) Investigation instrument suite on SPP will measure the bulk solar wind conditions in the inner heliosphere. SWEAP consists of the Solar Probe Cup (SPC), a sun-pointing Faraday Cup, and the Solar Probe ANalyzers (SPAN), a set of 3 electrostatic analyzers that will reside in the penumbra of SPP's thermal protection system and measure solar wind ions and electrons. SPP is scheduled to launch in 2018 into an equatorial solar orbit where a sequence of Venus gravity assists will gradually lower its closest solar approach to within 9.5 solar radii (RS) of the center of the Sun. The photon flux at 9.5 RS is more than 500 times greater than at 1 AU and therefore presents a design challenge for SPC, which will point directly at the Sun. SPC is derived from the Faraday cup instruments successfully flown on spacecraft from the beginning of the space age, but updated with high temperature materials to operate through the solar encounters. Current work includes both instrument design and the development of a testing approach capable of demonstrating adequate performance in encounter conditions. This paper will briefly discuss the suite as a whole, and then focus on the design and capabilities of SPC. We will also present the planned calibration and characterization of the instrument and the testing required to demonstrate the technological readiness of the design.

  20. Acceleration Modes and Transitions in Pulsed Plasma Accelerators

    NASA Technical Reports Server (NTRS)

    Polzin, Kurt A.; Greve, Christine M.

    2018-01-01

    Pulsed plasma accelerators typically operate by storing energy in a capacitor bank and then discharging this energy through a gas, ionizing and accelerating it through the Lorentz body force. Two plasma accelerator types employing this general scheme have typically been studied: the gas-fed pulsed plasma thruster and the quasi-steady magnetoplasmadynamic (MPD) accelerator. The gas-fed pulsed plasma accelerator is generally represented as a completely transient device discharging in approximately 1-10 microseconds. When the capacitor bank is discharged through the gas, a current sheet forms at the breech of the thruster and propagates forward under a j (current density) by B (magnetic field) body force, entraining propellant it encounters. This process is sometimes referred to as detonation-mode acceleration because the current sheet representation approximates that of a strong shock propagating through the gas. Acceleration of the initial current sheet ceases when either the current sheet reaches the end of the device and is ejected or when the current in the circuit reverses, striking a new current sheet at the breech and depriving the initial sheet of additional acceleration. In the quasi-steady MPD accelerator, the pulse is lengthened to approximately 1 millisecond or longer and maintained at an approximately constant level during discharge. The time over which the transient phenomena experienced during startup typically occur is short relative to the overall discharge time, which is now long enough for the plasma to assume a relatively steady-state configuration. The ionized gas flows through a stationary current channel in a manner that is sometimes referred to as the deflagration-mode of operation. The plasma experiences electromagnetic acceleration as it flows through the current channel towards the exit of the device. A device that had a short pulse length but appeared to operate in a plasma acceleration regime different from the gas-fed pulsed plasma

  1. Experimental study for the reproduction of sudden unintended acceleration incidents.

    PubMed

    Park, Sungji; Choi, Youngsuk; Choi, Woongchul

    2016-10-01

    A few cases of the sudden unintended acceleration have been reported over the last few years [1-11] and some of them seemed to be somewhat related to an electronic throttle control (ETC) system [11,12]. In this experimental study, efforts were made to reproduce the cases of sudden unintended acceleration possibly related to the ETC. Typically, an ETC of the engine is managed based on signals from airflow sensor, throttle position sensor and acceleration pedal sensor. With this typical sensor configuration in mind, these sensor signals were checked for noise levels. However, none of them showed any clear relationship with the sudden unintended acceleration mainly due to the robustness of the ETC logic software. As an alternative approach, supply voltage to an engine control unit (ECU) was tempered intentionally to observe any clues for the incidents. The observed results with the supply voltage drop and fluctuation tests were rather astonishing. The throttle valve position went all the way up to 100% for around one second when the battery voltage plunged down to 7V periodically despite that the acceleration pedal position was kept steady. As an effort to confirm the case, multiple tries were made systematically on a chassis dynamometer as well as on the test road. In this paper, detailed procedures and findings are reported accordingly. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Van Allen Probe Charging During the St. Patrick's Day Event

    NASA Technical Reports Server (NTRS)

    Parker, L. Neergaard; Minow, J. I.

    2015-01-01

    The geomagnetic storms on and around March 17, 2015 marked the largest storms seen in the declining phase of the solar cycle to date. We use the Helium Oxygen Proton Electron (HOPE) mass spectrometer on board the Van Allen Probe - A and B satellites to study in detail the charging effects seen on these spacecraft during this time. Ion particle flux data provides information on the magnitude of the charging events using the ion line charging signature due to low energy ions accelerated by the spacecraft potential. Electron flux observations are used to correlate the charging environment with variations in spacecraft potential through the event. We also investigate the density and temperature of ions and electrons during the time of the charging event.

  3. Compact Plasma Accelerator for Micropropulsion Applications

    NASA Technical Reports Server (NTRS)

    Foster, John E.

    2001-01-01

    There is a need for a low power, light-weight (compact), high specific impulse electric propulsion device to satisfy mission requirements for microsatellite (1 to 20 kg) class missions. Satisfying these requirements entails addressing the general problem of generating a sufficiently dense plasma within a relatively small volume and then accelerating it. In the work presented here, the feasibility of utilizing a magnetic cusp to generate a dense plasma over small length scales of order 1 mm is investigated. This approach could potentially mitigate scaling issues associated with conventional ion thruster plasma containment schemes. Plume and discharge characteristics were documented using a Faraday probe and a retarding potential analyzer.

  4. Remote Sensing Measurements of the Corona with the Solar Probe

    NASA Technical Reports Server (NTRS)

    Habbal, Shadia Rifai; Woo, Richard

    1996-01-01

    Remote sensing measurements of the solar corona are indespensible for the exploration of the source and acceleration regions of the solar wind which are inaccessible to in situ plasma, paritcles and field experiments.Furthermore, imaging the solar disk and coronal from the unique vantage point of the trajectory and the proximity of the Solar Probe spacecraft, will provide the first ever opportunity to explore the small scale structures within coronal holes and streamers from viewing angles and with spatial resolutions never attained before.

  5. Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling

    PubMed Central

    Takano, Yoko; Echizen, Honami

    2017-01-01

    Abstract Significance: Hydrogen sulfide (H2S) plays roles in many physiological processes, including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition of insulin signaling, and regulation of inflammation. Also, hydropersulfide (R−S−SH) and polysulfide (−S−Sn−S−) have recently been identified as reactive sulfur species (RSS) that regulate the bioactivities of multiple proteins via S-sulfhydration of cysteine residues (protein Cys−SSH) and show cytoprotection. Chemical tools such as fluorescent probes and selective inhibitors are needed to establish in detail the physiological roles of H2S and polysulfide. Recent Advances: Although many fluorescent probes for H2S are available, fluorescent probes for hydropersulfide and polysulfide have only recently been developed and used to detect these sulfur species in living cells. Critical Issues: In this review, we summarize recent progress in developing chemical tools for the study of H2S, hydropersulfide, and polysulfide, covering fluorescent probes based on various design strategies and selective inhibitors of H2S- and polysulfide-producing enzymes (cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase), and we summarize their applications in biological studies. Future Directions: Despite recent progress, the precise biological functions of H2S, hydropersulfide, and polysulfide remain to be fully established. Fluorescent probes and selective inhibitors are effective chemical tools to study the physiological roles of these sulfur molecules in living cells and tissues. Therefore, further development of a broad range of practical fluorescent probes and selective inhibitors as tools for studies of RSS biology is currently attracting great interest. Antioxid. Redox Signal. 27, 669–683. PMID:28443673

  6. Spectrophotometric probe

    DOEpatents

    Prather, W.S.; O'Rourke, P.E.

    1994-08-02

    A support structure is described bearing at least one probe for making spectrophotometric measurements of a fluid using a source of light and a spectrophotometer. The probe includes a housing with two optical fibers and a planoconvex lens. A sleeve bearing a mirror surrounds the housing. The lens is separated from the mirror by a fixed distance, defining an interior space for receiving a volume of the fluid sample. A plurality of throughholes extending through the sleeve communicate between the sample volume and the exterior of the probe, all but one hole bearing a screen. A protective jacket surrounds the probe. A hollow conduit bearing a tube is formed in the wall of the probe for venting any air in the interior space when fluid enters. The probe is held at an acute angle so the optic fibers carrying the light to and from the probe are not bent severely on emergence from the probe. 3 figs.

  7. Spectrophotometric probe

    DOEpatents

    Prather, William S.; O'Rourke, Patrick E.

    1994-01-01

    A support structure bearing at least one probe for making spectrophotometric measurements of a fluid using a source of light and a spectrophotometer. The probe includes a housing with two optical fibers and a planoconvex lens. A sleeve bearing a mirror surrounds the housing. The lens is separated from the mirror by a fixed distance, defining an interior space for receiving a volume of the fluid sample. A plurality of throughholes extending through the sleeve communicate between the sample volume and the exterior of the probe, all but one hole bearing a screen. A protective jacket surrounds the probe. A hollow conduit bearing a tube is formed in the wall of the probe for venting any air in the interior space when fluid enters. The probe is held at an acute angle so the optic fibers carrying the light to and from the probe are not bent severely on emergence from the probe.

  8. Basic and applied studies of the ram accelerator as a hypervelocity projectile launcher

    NASA Astrophysics Data System (ADS)

    Bruckner, Adam P.; Knowlen, Carl

    1993-12-01

    The potential of using ram accelerator technology for an impulsive launcher of autonomously guided interceptors, such as the LEAP, has been studied during this contract period. In addition, fundamental investigations on some of the engineering issues which must be addressed for enabling ram accelerator propulsive modes to operate at 4 km/sec have been undertaken. An experimental investigation of the gas dynamic limits of ram accelerator operation has demonstrated the existence of two distinct limiting mechanisms that must be accounted for when designing projectiles for these launchers. Other experiments were conducted to make detailed pressure measurements of the flow fields at the tube walls to study the effects of projectile canting. Results from this LEAP launcher study and the experimental investigations indicate that the ram accelerator technology is well suited for applications as a transportable launcher capable of meeting the needs of theater ballistic missile defense missions.

  9. Accelerated stability studies of Sufoofe Sailan: A Unani formulation

    PubMed Central

    Rani, Seema; Rahman, Khaleequr; Younis, Peerzada Mohammad

    2015-01-01

    Introduction: Sufoofe Sailan (SS) is a polyherbal powder preparation used in Unani medicine to treat gynecological diseases. It is observed that SS degrade early as it is in the form of powder; however, the stability study of SS was not carried out till date. Aim: To evaluate the accelerated stability of SS. Materials and Methods: Finished formulation of SS was packed in three airtight transparent polyethylene terephthalate containers. One pack was analyzed just after manufacturing and remaining two packs were kept in stability chamber at 40°C ± 2°C/75% ± 5% RH, of which one pack was analyzed after the completion of three and another after 6 months. Organoleptic, physico-chemical, microbiological parameters along with high-performance thin layer chromatography (HPTLC) fingerprinting were carried out. Results: Organoleptic characters showed no significant change in accelerated stability condition. All physico-chemical parameters showed changes <5%, HPTLC fingerprinting showed minimum changes and microbial studies were in confirmation to the World Health Organization guidelines. Conclusion: SS confirmed to the International Conference on Harmonization Guideline for accelerated testing of the pharmaceutical product on said parameters and as per the Grimm's statement the shelf life of SS may last 20 months. PMID:26730145

  10. FAST/Polar Conjunction Study of Field-Aligned Auroral Acceleration and Corresponding Magnetotail Drivers

    NASA Technical Reports Server (NTRS)

    Schriver, D.; Ashour-Abdalla, M.; Strangeway, R. J.; Richard, R. L.; Klezting, C.; Dotan, Y.; Wygant, J.

    2002-01-01

    The discrete aurora results when energized electrons bombard the Earth's atmosphere at high latitudes. This paper examines the physical processes that can cause field-aligned acceleration of plasma particles in the auroral region. A data and theoretical study has been carried out to examine the acceleration mechanisms that operate in the auroral zone and to identity the magnetospheric drivers of these acceleration mechanisms. The observations used in the study were collected by the Fast Auroral SnapshoT (FAST) and Polar satellites when the two satellites were in approximate magnetic conjunction in the auroral region. During these events FAST was in the middle of the auroral zone and Polar was above the auroral zone in the near-Earth plasma sheet. Polar data was used to determine the conditions in the magnetotail at the time field-aligned acceleration was measured by FAST in the auroral zone. For each of the magnetotail drivers identified in the data study, the physics of field-aligned acceleration in the auroral region was examined using existing theoretical efforts and a long-system particle-in-cell simulation to model the magnetically connected region between the two satellites.

  11. Pulsed electromagnetic acceleration

    NASA Technical Reports Server (NTRS)

    Jahn, R. G.; Vonjaskowsky, W. F.; Clark, K. E.

    1973-01-01

    Direct measurements of the power deposited in the anode of a multimegawatt MPD accelerator using thermocouples attached to a thin shell anode reveal a dramatic decrease in the fractional anode power from 50% at 200 KW input power to less than 10% at 20 MW power. The corresponding local power flux peak at a value of 10,000 W/sq cm at the lip of the anode exhaust orifice, a distribution traced to a corresponding peak in the local current density at the anode. A comparison of voltage-current characteristics and spectral photographs of the MPD discharge using quartz, boron nitride and plexiglas insulators with various mass injection configurations led to the identification of different voltage modes and regions of ablation free operation. The technique of piezoelectric impact pressure measurement in the MPD exhaust flow was refined to account for the effects due to probe yaw angle.

  12. Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe

    PubMed Central

    Niccolai, Neri; Spadaccini, Roberta; Scarselli, Maria; Bernini, Andrea; Crescenzi, Orlando; Spiga, Ottavia; Ciutti, Arianna; Di Maro, Daniela; Bracci, Luisa; Dalvit, Claudio; Temussi, Piero A.

    2001-01-01

    The design of safe sweeteners is very important for people who are affected by diabetes, hyperlipemia, and caries and other diseases that are linked to the consumption of sugars. Sweet proteins, which are found in several tropical plants, are many times sweeter than sucrose on a molar basis. A good understanding of their structure–function relationship can complement traditional SAR studies on small molecular weight sweeteners and thus help in the design of safe sweeteners. However, there is virtually no sequence homology and very little structural similarity among known sweet proteins. Studies on mutants of monellin, the best characterized of sweet proteins, proved not decisive in the localization of the main interaction points of monellin with its receptor. Accordingly, we resorted to an unbiased approach to restrict the search of likely areas of interaction on the surface of a typical sweet protein. It has been recently shown that an accurate survey of the surface of proteins by appropriate paramagnetic probes may locate interaction points on protein surface. Here we report the survey of the surface of MNEI, a single chain monellin, by means of a paramagnetic probe, and a direct assessment of bound water based on an application of ePHOGSY, an NMR experiment that is ideally suited to detect interactions of small ligands to a protein. Detailed surface mapping reveals the presence, on the surface of MNEI, of interaction points that include residues previously predicted by ELISA tests and by mutagenesis. PMID:11468346

  13. Experimental study of the transient hydrogen jet - Using a fast response probe

    NASA Astrophysics Data System (ADS)

    Tanabe, H.; Ohnishi, M.; Sato, G. T.; Fujimoto, H.

    Mixing processes of a transient hydrogen jet, such as those of a hydrogen-injection internal combustion engine, are studied by means of a concentration probe having a response time of less than 200 microsec. Hydrogen was injected into quiescent air by means of (1) a single-shot device, in order to study the air interactions of the jet with schlieren photography and smoke wire methods, and (2) a hydrogen diesel engine injection nozzle to determine jet shape with high speed schlieren photography. The concentration probe's response time was found to be adequate for the very short injection period, and it was determined that air-hydrogen mixing in the case of high jet momentum is governed by eddy diffusion.

  14. Mechanistic Study of the Validity of Using Hydroxyl Radical Probes To Characterize Electrochemical Advanced Oxidation Processes.

    PubMed

    Jing, Yin; Chaplin, Brian P

    2017-02-21

    The detection of hydroxyl radicals (OH • ) is typically accomplished by using reactive probe molecules, but prior studies have not thoroughly investigated the suitability of these probes for use in electrochemical advanced oxidation processes (EAOPs), due to the neglect of alternative reaction mechanisms. In this study, we investigated the suitability of four OH • probes (coumarin, p-chlorobenzoic acid, terephthalic acid, and p-benzoquinone) for use in EAOPs. Experimental results indicated that both coumarin and p-chlorobenzoic acid are oxidized via direct electron transfer reactions, while p-benzoquinone and terephthalic acid are not. Coumarin oxidation to form the OH • adduct product 7-hydroxycoumarin was found at anodic potentials lower than that necessary for OH • formation. Density functional theory (DFT) simulations found a thermodynamically favorable and non-OH • mediated pathway for 7-hydroxycoumarin formation, which is activationless at anodic potentials > 2.10 V/SHE. DFT simulations also provided estimates of E° values for a series of OH • probe compounds, which agreed with voltammetry results. Results from this study indicated that terephthalic acid is the most appropriate OH • probe compound for the characterization of electrochemical and catalytic systems.

  15. GPU Accelerated Chemical Similarity Calculation for Compound Library Comparison

    PubMed Central

    Ma, Chao; Wang, Lirong; Xie, Xiang-Qun

    2012-01-01

    Chemical similarity calculation plays an important role in compound library design, virtual screening, and “lead” optimization. In this manuscript, we present a novel GPU-accelerated algorithm for all-vs-all Tanimoto matrix calculation and nearest neighbor search. By taking advantage of multi-core GPU architecture and CUDA parallel programming technology, the algorithm is up to 39 times superior to the existing commercial software that runs on CPUs. Because of the utilization of intrinsic GPU instructions, this approach is nearly 10 times faster than existing GPU-accelerated sparse vector algorithm, when Unity fingerprints are used for Tanimoto calculation. The GPU program that implements this new method takes about 20 minutes to complete the calculation of Tanimoto coefficients between 32M PubChem compounds and 10K Active Probes compounds, i.e., 324G Tanimoto coefficients, on a 128-CUDA-core GPU. PMID:21692447

  16. Clinical tests of an ultrasonic periodontal probe

    NASA Astrophysics Data System (ADS)

    Hinders, Mark K.; Lynch, John E.; McCombs, Gayle B.

    2002-05-01

    A new ultrasonic periodontal probe has been developed that offers the potential for earlier detection of periodontal disease activity, non-invasive diagnosis, and greater reliability of measurement. A comparison study of the ultrasonic probe to both a manual probe, and a controlled-force probe was conducted to evaluate its clinical effectiveness. Twelve patients enrolled into this study. Two half-month examinations were conducted on each patient, scheduled one hour apart. A one-way analysis of variance was performed to compare the results for the three sets of probing depth measurements, followed by a repeated measures analysis to assess the reproducibility of the different probing techniques. These preliminary findings indicate that manual and ultrasonic probing measure different features of the pocket. Therefore, it is not obvious how the two depth measurements correspond to each other. However, both methods exhibited a similar tendency toward increasing pocket depths as Gingival Index scores increased. Based on the small sample size, further studies need to be conducted using a larger population of patients exhibiting a wider range of disease activity. In addition, studies that allow histological examination of the pocket after probing will help further evaluate the clinical effectiveness the ultrasonic probe. Future studies will also aid in the development of more effective automated feature recognition algorithms that convert the ultrasonic echoes into pocket depth readings.

  17. Coupling between non-thermal plasmas and magnetic fields in space: in situ and remote observations with Parker Solar Probe and SunRISE

    NASA Astrophysics Data System (ADS)

    Kasper, J. C.

    2017-12-01

    This talk will review examples of open questions in the coupling between non-thermal plasmas and magnetic fields in space, including pressure anisotropies, in heating, and particle acceleration, in the context of space missions either preparing for launch or under study and using in situ observations or remote sensing techniques. The Parker Solar Probe, with launch in the summer of next year, will collect the first in situ samples of plasma in the outer corona, allowing us to directly observe the physical processes responsible for the heating and acceleration of the solar corona and solar wind. The Sun Radio Interferometer Space Experiment (SunRISE) mission is a low frequency radio array under study by NASA which would image for the first time locations of particle acceleration relative to coronal mass ejections and trace magnetic field lines that connect active regions to the heliosphere. Major open questions under investigation by these techniques will be explored, with an eye to connections to laboratory experiments.

  18. Studies of dished accelerator grids for 30-cm ion thrusters

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1973-01-01

    Eighteen geometrically different sets of dished accelerator grids were tested on five 30-cm thrusters. The geometric variation of the grids included the grid-to-grid spacing, the screen and accelerator hole diameters and thicknesses, the screen and accelerator open area fractions, ratio of dish depth to dish diameter, compensation, and aperture shape. In general, the data taken over a range of beam currents for each grid set included the minimum total accelerating voltage required to extract a given beam current and the minimum accelerator grid voltage required to prevent electron backstreaming.

  19. The stratified two-sided jet of Cygnus A. Acceleration and collimation

    NASA Astrophysics Data System (ADS)

    Boccardi, B.; Krichbaum, T. P.; Bach, U.; Mertens, F.; Ros, E.; Alef, W.; Zensus, J. A.

    2016-01-01

    Aims: High-resolution Very-Long-Baseline Interferometry (VLBI) observations of relativistic jets are essential for constraining the fundamental parameters of jet formation models. At a distance of 249 Mpc, Cygnus A is a unique target for such studies, since it is the only Fanaroff-Riley Class II radio galaxy for which a detailed subparsec scale imaging of the base of both jet and counter-jet can be obtained. Observing at millimeter wavelengths unveils those regions that appear self-absorbed at longer wavelengths and enables an extremely sharp view toward the nucleus to be obtained. Methods: We performed 7 mm Global VLBI observations, achieving ultra-high resolution imaging on scales down to 90 μas. This resolution corresponds to a linear scale of only ~400 Schwarzschild radii (for MBH = 2.5 × 109M⊙). We studied the kinematic properties of the main emission features of the two-sided flow and probed its transverse structure through a pixel-based analysis. Results: We suggest that a fast and a slow layer with different acceleration gradients exist in the flow. The extension of the acceleration region is large (~ 104RS), indicating that the jet is magnetically driven. The limb brightening of both jet and counter-jet and their large opening angles (φJ ~ 10°) strongly favour a spine-sheath structure. In the acceleration zone, the flow has a parabolic shape (r ∝ z0.55 ± 0.07). The acceleration gradients and the collimation profile are consistent with the expectations for a jet in "equilibrium", achieved in the presence of a mild gradient of the external pressure (p ∝ z- k,k ≤ 2).

  20. Acceleration modules in linear induction accelerators

    NASA Astrophysics Data System (ADS)

    Wang, Shao-Heng; Deng, Jian-Jun

    2014-05-01

    The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.

  1. Establishment of an equivalence acceptance criterion for accelerated stability studies.

    PubMed

    Burdick, Richard K; Sidor, Leslie

    2013-01-01

    In this article, the use of statistical equivalence testing for providing evidence of process comparability in an accelerated stability study is advocated over the use of a test of differences. The objective of such a study is to demonstrate comparability by showing that the stability profiles under nonrecommended storage conditions of two processes are equivalent. Because it is difficult at accelerated conditions to find a direct link to product specifications, and hence product safety and efficacy, an equivalence acceptance criterion is proposed that is based on the statistical concept of effect size. As with all statistical tests of equivalence, it is important to collect input from appropriate subject-matter experts when defining the acceptance criterion.

  2. Aspheric surface measurement using capacitive probes

    NASA Astrophysics Data System (ADS)

    Tao, Xin; Yuan, Daocheng; Li, Shaobo

    2017-02-01

    With the application of aspheres in optical fields, high precision and high efficiency aspheric surface metrology becomes a hot research topic. We describe a novel method of non-contact measurement of aspheric surface with capacitive probe. Taking an eccentric spherical surface as the object of study, the averaging effect of capacitive probe measurement and the influence of tilting the capacitive probe on the measurement results are investigated. By comparing measurement results from simultaneous measurement of the capacitive probe and contact probe of roundness instrument, this paper indicates the feasibility of using capacitive probes to test aspheric surface and proposes the compensation method of measurement error caused by averaging effect and the tilting of the capacitive probe.

  3. Study on the SPR responses of various DNA probe concentrations by parallel scan spectral SPR imaging

    NASA Astrophysics Data System (ADS)

    Ma, Suihua; Liu, Le; Lu, Weiping; Zhang, Yaou; He, Yonghong; Guo, Jihua

    2008-12-01

    SPR sensors have become a high sensitive and label free method for characterizing and quantifying chemical and biochemical interactions. However, the relations between the SPR refractive index response and the property (such as concentrations) of biochemical probes are still lacking. In this paper, an experimental study on the SPR responses of varies concentrations of Legionella pneumophila mip DNA probes is presented. We developed a novel two-dimensional SPR sensing technique-parallel scan spectral SPR imaging-to detect an array of mip gene probes. This technique offers quantitative refractive index information with a high sensing throughput. By detecting mip DNA probes with different concentrations, we obtained the relations between the SPR refractive index response and the concentrations of mip DNA probes. These results are valuable for design and developing SPR based mip gene biochips.

  4. Efficacy of the heater probe in peptic ulcer with a non-bleeding visible vessel. A controlled, randomised study.

    PubMed Central

    Jaramillo, J L; Carmona, C; Gálvez, C; de la Mata, M; Miño, G

    1993-01-01

    A controlled, randomised study was performed to evaluate the efficacy of treatment with heater probe in the prevention of rebleeding from peptic ulcer with a non-bleeding visible vessel. One hundred and one patients were randomised into two groups: patients to be treated by heater probe (n = 51) and controls without active treatment (n = 50). In the heater probe group rebleeding occurred in five patients (10%) v 13 (26%) in the control group (p = 0.03), with a comparative risk of 0.38 in favour of the heater probe group. The difference in proportions of successful treatment for each group was 16.2% in favour of the heater probe (95% CI = 2 to 31%). Haemorrhage directly related to heater probe treatment occurred in four patients. In three of them bleeding was easily controlled by further heater probe pulses. There were no other complications and no death in the heater probe group. One patient in the control group died of pulmonary embolism. No significant differences in the length of stay in hospital, blood transfusions, surgical rates, or death were found; the design of the study, however, precluded an adequate assessment of these variables, because the heater probe was an optional rescue treatment when high surgical risk patients rebled. These results suggest that the heater probe is an effective and safe procedure in the prevention of recurrent haemorrhage in peptic ulcer with a non-bleeding visible vessel. PMID:8244132

  5. EPR spin probe and spin label studies of some low molecular and polymer micelles

    NASA Astrophysics Data System (ADS)

    Wasserman, A. M.; Kasaikin, V. A.; Timofeev, V. P.

    1998-12-01

    The rotational mobility of spin probes of different shape and size in low molecular and polymer micelles has been studied. Several probes having nitroxide fragment localized either in the vicinity of micelle interface or in the hydrocarbon core have been used. Upon increasing the number of carbon atoms in hydrocarbon chain of detergent from 7 to 13 (sodium alkyl sulfate micelles) or from 12 to 16 (alkyltrimethylammonium bromide micelles) the rotational mobility of spin probes is decreased by the factor 1.5-2.0. The spin probe rotational mobility in polymer micelles (the complexes of alkyltrimethylammonium bromides and polymethacrylic or polyacrylic acids) is less than mobility in free micelles of the same surfactants. The study of EPR-spectra of spin labeled polymethacrylic acid (PMA) indicated that formation of water soluble complexes of polymer and alkyltrimethylammonium bromides in alkaline solutions (pH 9) does not affect the polymer segmental mobility. On the other hand, the polymer complexes formation in slightly acidic water solution (pH 6) breaks down the compact PMA conformation, thus increasing the polymer segmental mobility. Possible structures of polymer micelles are discussed.

  6. Scanned-probe field-emission studies of vertically aligned carbon nanofibers

    NASA Astrophysics Data System (ADS)

    Merkulov, Vladimir I.; Lowndes, Douglas H.; Baylor, Larry R.

    2001-02-01

    Field emission properties of dense and sparse "forests" of randomly placed, vertically aligned carbon nanofibers (VACNFs) were studied using a scanned probe with a small tip diameter of ˜1 μm. The probe was scanned in directions perpendicular and parallel to the sample plane, which allowed for measuring not only the emission turn-on field at fixed locations but also the emission site density over large surface areas. The results show that dense forests of VACNFs are not good field emitters as they require high extracting (turn-on) fields. This is attributed to the screening of the local electric field by the neighboring VACNFs. In contrast, sparse forests of VACNFs exhibit moderate-to-low turn-on fields as well as high emission site and current densities, and long emission lifetime, which makes them very promising for various field emission applications.

  7. Frequency-Domain Streak Camera and Tomography for Ultrafast Imaging of Evolving and Channeled Plasma Accelerator Structures

    NASA Astrophysics Data System (ADS)

    Li, Zhengyan; Zgadzaj, Rafal; Wang, Xiaoming; Reed, Stephen; Dong, Peng; Downer, Michael C.

    2010-11-01

    We demonstrate a prototype Frequency Domain Streak Camera (FDSC) that can capture the picosecond time evolution of the plasma accelerator structure in a single shot. In our prototype Frequency-Domain Streak Camera, a probe pulse propagates obliquely to a sub-picosecond pump pulse that creates an evolving nonlinear index "bubble" in fused silica glass, supplementing a conventional Frequency Domain Holographic (FDH) probe-reference pair that co-propagates with the "bubble". Frequency Domain Tomography (FDT) generalizes Frequency-Domain Streak Camera by probing the "bubble" from multiple angles and reconstructing its morphology and evolution using algorithms similar to those used in medical CAT scans. Multiplexing methods (Temporal Multiplexing and Angular Multiplexing) improve data storage and processing capability, demonstrating a compact Frequency Domain Tomography system with a single spectrometer.

  8. Electron Beams Escaping the Sun: Hard X-ray Diagnostics of Jet-related Electron Acceleration

    NASA Astrophysics Data System (ADS)

    Glesener, L.; Musset, S.; Saint-Hilaire, P.; Fleishman, G. D.; Krucker, S.; Christe, S.; Shih, A. Y.

    2017-12-01

    Coronal jets, which arise via an interaction between closed and open magnetic field, offer a convenient configuration for accelerated electrons to escape the low corona. Jets occur in all regions of the Sun, but those flare-related jets that occur in active regions are associated with bremsstrahlung hard X-rays (HXRs) from accelerated electrons. However, HXR measurement of the escaping beams themselves is elusive as it requires extremely high sensitivity. Jets are strongly correlated with Type III radio bursts in the corona and in interplanetary space. In this poster we present RHESSI observations of HXRs from flare-related jets, including multiwavelength analysis (with extreme ultraviolet and radio emission) and modeling of the emitting electron populations. We also present predicted observations of Type III-emitting electron beams by the FOXSI Small Explorer, which is currently undergoing a NASA Phase A concept study. FOXSI will measure HXRs from jets and flares in the low corona, providing quantitative diagnostics of accelerated electron beams at their origin. These same electron beams will be measured at higher altitudes by instruments aboard NASA's Parker Solar Probe and ESA's Solar Orbiter. With a planned launch in the rising phase of Solar Cycle 25, FOXSI will be ideally timed and optimized for collaborative study of electron beams escaping the Sun.

  9. PROBING DYNAMICS OF ELECTRON ACCELERATION WITH RADIO AND X-RAY SPECTROSCOPY, IMAGING, AND TIMING IN THE 2002 APRIL 11 SOLAR FLARE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fleishman, Gregory D.; Nita, Gelu M.; Gary, Dale E.

    Based on detailed analysis of radio and X-ray observations of a flare on 2002 April 11 augmented by realistic three-dimensional modeling, we have identified a radio emission component produced directly at the flare acceleration region. This acceleration region radio component has distinctly different (1) spectrum, (2) light curves, (3) spatial location, and, thus, (4) physical parameters from those of the separately identified trapped or precipitating electron components. To derive evolution of physical parameters of the radio sources we apply forward fitting of the radio spectrum time sequence with the gyrosynchrotron source function with five to six free parameters. At themore » stage when the contribution from the acceleration region dominates the radio spectrum, the X-ray- and radio-derived electron energy spectral indices agree well with each other. During this time the maximum energy of the accelerated electron spectrum displays a monotonic increase with time from {approx}300 keV to {approx}2 MeV over roughly one minute duration indicative of an acceleration process in the form of growth of the power-law tail; the fast electron residence time in the acceleration region is about 2-4 s, which is much longer than the time of flight and so requires a strong diffusion mode there to inhibit free-streaming propagation. The acceleration region has a relatively strong magnetic field, B {approx} 120 G, and a low thermal density, n{sub e} {approx}< 2 Multiplication-Sign 10{sup 9} cm{sup -3}. These acceleration region properties are consistent with a stochastic acceleration mechanism.« less

  10. Preliminary assessment of the electromagnetic environment in the immediate vicinity of the ETA accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cabayan, H.S.; Bogdan, E.; Zicker, J.

    The electromagnetic fields in the immediate vicinity of the Experimental Test Accelerator (ETA) at the Lawrence Livermore Laboratory have been characterized. Various EM sensors that cover the frequency band from the very low frequencies up into the GHz region have been used. The report describes in detail the probes, the test set-up and the data processing techniques.

  11. Hydrodynamic ultrasonic probe

    DOEpatents

    Day, Robert A.; Conti, Armond E.

    1980-01-01

    An improved probe for in-service ultrasonic inspection of long lengths of a workpiece, such as small diameter tubing from the interior. The improved probe utilizes a conventional transducer or transducers configured to inspect the tubing for flaws and/or wall thickness variations. The probe utilizes a hydraulic technique, in place of the conventional mechanical guides or bushings, which allows the probe to move rectilinearly or rotationally while preventing cocking thereof in the tube and provides damping vibration of the probe. The probe thus has lower friction and higher inspection speed than presently known probes.

  12. Ion Spectral Structures Observed by the Van Allen Probes and Cluster

    NASA Astrophysics Data System (ADS)

    Ferradas, C.; Zhang, J.; Luo, H.; Kistler, L. M.; Spence, H. E.; Larsen, B.; Skoug, R. M.; Funsten, H. O.; Reeves, G. D.

    2014-12-01

    During the last decades several missions have recorded the presence of dynamic spectral features of energetic ions in the inner magnetosphere. Previous studies have revealed single "nose-like" structures occurring alone and simultaneous nose-like structures (up to three). In this study we also include signatures of new types of ion structure, namely "trunk-like" and "tusk-like" structures. All the ion structures are named after the characteristic shapes of energy bands or gaps in the energy-time spectrograms of in situ measured ion fluxes. They constitute the observational signatures of ion acceleration, transport, and loss in the global magnetosphere. Multi-spacecraft analysis of these structures is important to understand their spatial distribution and temporal evolution. Mass spectrometers onboard Cluster (in a polar orbit) and the Van Allen Probes (in an equatorial orbit) measure energetic hydrogen, helium, and oxygen ions near the inner edge of the plasma sheet, where these ion structures are observed. We present a statistical study of the ion structures, using >1-year measurements from the two missions during the Van Allen Probes era. The results provide important details about the spatial distribution (dependence on geocentric distance and magnetic local time), spectral features of the structures (e.g., characteristic energy and differences among species), and geomagnetic and solar wind conditions under which these structures occur.

  13. IEC Thrusters for Space Probe Applications and Propulsion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miley, George H.; Momota, Hiromu; Wu Linchun

    Earlier conceptual design studies (Bussard, 1990; Miley et al., 1998; Burton et al., 2003) have described Inertial Electrostatic Confinement (IEC) fusion propulsion to provide a high-power density fusion propulsion system capable of aggressive deep space missions. However, this requires large multi-GW thrusters and a long term development program. As a first step towards this goal, a progression of near-term IEC thrusters, stating with a 1-10 kWe electrically-driven IEC jet thruster for satellites are considered here. The initial electrically-powered unit uses a novel multi-jet plasma thruster based on spherical IEC technology with electrical input power from a solar panel. In thismore » spherical configuration, Xe ions are generated and accelerated towards the center of double concentric spherical grids. An electrostatic potential well structure is created in the central region, providing ion trapping. Several enlarged grid opening extract intense quasi-neutral plasma jets. A variable specific impulse in the range of 1000-4000 seconds is achieved by adjusting the grid potential. This design provides high maneuverability for satellite and small space probe operations. The multiple jets, combined with gimbaled auxiliary equipment, provide precision changes in thrust direction. The IEC electrical efficiency can match or exceed efficiencies of conventional Hall Current Thrusters (HCTs) while offering advantages such as reduced grid erosion (long life time), reduced propellant leakage losses (reduced fuel storage), and a very high power-to-weight ratio. The unit is ideally suited for probing missions. The primary propulsive jet enables delicate maneuvering close to an object. Then simply opening a second jet offset 180 degrees from the propulsion one provides a 'plasma analytic probe' for interrogation of the object.« less

  14. Social-Emotional Characteristics of Gifted Accelerated and Non-Accelerated Students in the Netherlands

    ERIC Educational Resources Information Center

    Hoogeveen, Lianne; van Hell, Janet G.; Verhoeven, Ludo

    2012-01-01

    Background: In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. Aims: In this study, social-emotional characteristics of accelerated…

  15. Observation of Chorus Waves by the Van Allen Probes: Dependence on Solar Wind Parameters and Scale Size

    NASA Technical Reports Server (NTRS)

    Aryan, Homayon; Sibeck, David; Balikhin, Michael; Agapitov, Oleksiy; Kletzing, Craig

    2016-01-01

    Highly energetic electrons in the Earths Van Allen radiation belts can cause serious damage to spacecraft electronic systems and affect the atmospheric composition if they precipitate into the upper atmosphere. Whistler mode chorus waves have attracted significant attention in recent decades for their crucial role in the acceleration and loss of energetic electrons that ultimately change the dynamics of the radiation belts. The distribution of these waves in the inner magnetosphere is commonly presented as a function of geomagnetic activity. However, geomagnetic indices are nonspecific parameters that are compiled from imperfectly covered ground based measurements. The present study uses wave data from the two Van Allen Probes to present the distribution of lower band chorus waves not only as functions of single geomagnetic index and solar wind parameters but also as functions of combined parameters. Also the current study takes advantage of the unique equatorial orbit of the Van Allen Probes to estimate the average scale size of chorus wave packets, during close separations between the two spacecraft, as a function of radial distance, magnetic latitude, and geomagnetic activity, respectively. Results show that the average scale size of chorus wave packets is approximately 13002300 km. The results also show that the inclusion of combined parameters can provide better representation of the chorus wave distributions in the inner magnetosphere and therefore can further improve our knowledge of the acceleration and loss of radiation belt electrons.

  16. Work on Planetary Atmospheres and Planetary Atmosphere Probes

    NASA Technical Reports Server (NTRS)

    Seiff, Alvin; Lester, Peter

    1999-01-01

    instrument performance, although performed greater than 5 years prior to Jupiter encounter. Capability of decoding the science data from the Experiment Data Record to be provided at encounter was developed and exercised using the tape recording of the first Cruise Checkout data. A team effort was organized to program the selection and combination of data words defining pressure, temperature, acceleration, turbulence, and engineering quantities; to apply decalibration algorithms to convert readings from digital numbers to physical quantities; and to organize the data into a suitable printout. A paper on the Galileo Atmosphere Structure Instrument was written and submitted for publication in a special issue of Space Science Reviews. At the Journal editor's request, the grantee reviewed other Probe instrument papers submitted for this special issue. Calibration data were carefully taken for all experiment sensors and accumulated over a period of 10 years. The data were analyzed, fitted with algorithms, and summarized in a calibration report for use in analyzing and interpreting data returned from Jupiter's atmosphere. The sensors included were the primary science pressure, temperature, and acceleration sensors, and the supporting engineering temperature sensors. This report was distributed to experiment coinvestigators and the Probe Project Office.

  17. Titanium pigmentation. An electron probe microanalysis study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dupre, A.; Touron, P.; Daste, J.

    1985-05-01

    A patient had an unusual pigmentary disease induced by titanium dioxide. The use of a topical cream containing titanium dioxide caused a xanthomalike appearance on the patient's penis. Electron probe microanalysis was valuable in establishing the cause of this balanitis.

  18. Langmuir Probe Distortions and Probe Compensation in an Inductively Coupled Plasma

    NASA Technical Reports Server (NTRS)

    Ji, J. S.; Cappelli, M. A.; Kim, J. S.; Rao, M. V. V. S.; Sharma, S. P.

    1999-01-01

    In many RF discharges, Langmuir probe measurements are usually made against a background of sinusoidal (and not so sinusoidal) fluctuations in the plasma parameters such as the plasma potential (Vp), the electron number density (ne), and the electron temperature (Te). The compensation of sinusoidal fluctuations in Vp has been extensively studied and is relatively well understood. Less attention has been paid to the possible distortions introduced by small fluctuations in plasma density and/or plasma temperature, which may arise in the sheath and pre-sheath regions of RF discharges. Here, we present the results of a model simulation of probe characteristics subject to fluctuations in both Vp and ne. The modeling of probe distortion due to possible fluctuations in Te is less straightforward. A comparison is presented of calculations with experimental measurements using a compensated and uncompensated Langmuir probe in an inductively coupled GEC reference cell plasma, operating on Ar and Ar/CF4 mixtures. The plasma parameters determined from the compensated probe characteristics are compared to previous measurements of others made in similar discharges, and to our own measurements of the average electron density derived from electrical impedance measurements.

  19. Chimpanzees create and modify probe tools functionally: A study with zoo-housed chimpanzees.

    PubMed

    Hopper, Lydia M; Tennie, Claudio; Ross, Stephen R; Lonsdorf, Elizabeth V

    2015-02-01

    Chimpanzees (Pan troglodytes) use tools to probe for out-of-reach food, both in the wild and in captivity. Beyond gathering appropriately-sized materials to create tools, chimpanzees also perform secondary modifications in order to create an optimized tool. In this study, we recorded the behavior of a group of zoo-housed chimpanzees when presented with opportunities to use tools to probe for liquid foods in an artificial termite mound within their enclosure. Previous research with this group of chimpanzees has shown that they are proficient at gathering materials from within their environment in order to create tools to probe for the liquid food within the artificial mound. Extending beyond this basic question, we first asked whether they only made and modified probe tools when it was appropriate to do so (i.e. when the mound was baited with food). Second, by collecting continuous data on their behavior, we also asked whether the chimpanzees first (intentionally) modified their tools prior to probing for food or whether such modifications occurred after tool use, possibly as a by-product of chewing and eating the food from the tools. Following our predictions, we found that tool modification predicted tool use; the chimpanzees began using their tools within a short delay of creating and modifying them, and the chimpanzees performed more tool modifying behaviors when food was available than when they could not gain food through the use of probe tools. We also discuss our results in terms of the chimpanzees' acquisition of the skills, and their flexibility of tool use and learning. © 2014 Wiley Periodicals, Inc.

  20. Incidences of esophageal injury during esophageal temperature monitoring: a comparative study of a multi-thermocouple temperature probe and a deflectable temperature probe in atrial fibrillation ablation.

    PubMed

    Kuwahara, Taishi; Takahashi, Atsushi; Takahashi, Yoshihide; Okubo, Kenji; Takagi, Katsumasa; Fujino, Tadashi; Kusa, Shigeki; Takigawa, Masateru; Watari, Yuji; Yamao, Kazuya; Nakashima, Emiko; Kawaguchi, Naohiko; Hikita, Hiroyuki; Sato, Akira; Aonuma, Kazutaka

    2014-04-01

    The study aim was to compare the incidence of esophageal injuries between different temperature probes in the monitoring of esophageal temperature during atrial fibrillation (AF) ablation. One hundred patients with drug-resistant AF were prospectively and randomly assigned into two groups according to the esophageal temperature probe used: the multi-thermocouple probe group (n = 50) and the deflectable temperature probe group (n = 50). Extensive pulmonary vein (PV) isolation was performed with a 3.5-mm open irrigated tip ablation catheter by using a radiofrequency (RF) power of 25-30 W. In both groups, the esophageal temperature thermocouple was placed on the area of the esophagus adjacent to the ablation site. When the esophageal temperature reached 42 °C, the RF energy delivery was stopped. Esophageal endoscopy was performed 1 day after the catheter ablation. No differences existed between the two groups in terms of clinical background and various parameters related to the catheter ablation, including RF delivery time and number of RF deliveries at an esophageal temperature of >42 °C. Esophageal lesions, such as esophagitis and esophageal ulcers, occurred in 10/50 (20 %) and 15/50 (30 %) patients in the multi-thermocouple and deflectable temperature probe groups, respectively (P = 0.25). Most lesions were mild to moderate injuries, and all were cured using conservative treatment. The incidence of esophageal injury was almost equal between the multi-thermocouple temperature probe and the deflectable temperature probe during esophageal temperature monitoring. Most of the esophageal lesions that developed during esophageal temperature monitoring were mild to moderate and reversible.

  1. Multipactor Physics, Acceleration, and Breakdown in Dielectric-Loaded Accelerating Structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fischer, Richard P.; Gold, Steven H.

    2016-07-01

    The objective of this 3-year program is to study the physics issues associated with rf acceleration in dielectric-loaded accelerating (DLA) structures, with a focus on the key issue of multipactor loading, which has been found to cause very significant rf power loss in DLA structures whenever the rf pulsewidth exceeds the multipactor risetime (~10 ns). The experiments are carried out in the X-band magnicon laboratory at the Naval Research Laboratory (NRL) in collaboration with Argonne National Laboratory (ANL) and Euclid Techlabs LLC, who develop the test structures with support from the DoE SBIR program. There are two main elements inmore » the research program: (1) high-power tests of DLA structures using the magnicon output (20 MW @11.4 GHz), and (2) tests of electron acceleration in DLA structures using relativistic electrons from a compact X-band accelerator. The work during this period has focused on a study of the use of an axial magnetic field to suppress multipactor in DLA structures, with several new high power tests carried out at NRL, and on preparation of the accelerator for the electron acceleration experiments.« less

  2. Understanding non-equilibrium collisional and expansion effects in the solar wind with Parker Solar Probe

    NASA Astrophysics Data System (ADS)

    Korreck, K. E.; Klein, K. G.; Maruca, B.; Alterman, B. L.

    2017-12-01

    The evolution of the solar wind from the corona to the Earth and throughout the heliosphere is a complex interplay between local micro kinetics and large scale expansion effects. These processes in the solar wind need to be separated in order to understand and distinguish the dominant mechanism for heating and acceleration of the solar wind. With the upcoming launch in 2018 of Parker Solar Probe and the launch of Solar Orbiter after, addressing the local and global phenomena will be enabled with in situ measurements. Parker Solar Probe will go closer to the Sun than any previous mission enabling the ability to examine the solar wind at an early expansion age. This work examines the predictions for what will be seen inside of the 0.25 AU (54 solar radii) where Parker Solar Probe will take measurements and lays the groundwork for disentangling the expansion and collisional effects. In addition, methods of thermal plasma data analysis to determine the stability of the plasma in the Parker Solar Probe measurements will be discussed.

  3. Ion spectral structures observed by the Van Allen Probes

    NASA Astrophysics Data System (ADS)

    Ferradas, C.; Zhang, J.; Spence, H. E.; Kistler, L. M.; Larsen, B.; Reeves, G. D.; Skoug, R. M.; Funsten, H. O.

    2015-12-01

    During the last decades several missions have recorded the presence of dynamic spectral features of energetic ions in the inner magnetosphere. Previous studies have reported single "nose-like" structures occurring alone and simultaneous nose-like structures (up to three). These ion structures are named after the characteristic shapes of energy bands or gaps in the energy-time spectrograms of in situ measured ion fluxes. They constitute the observational signatures of ion acceleration, transport, and loss in the global magnetosphere. The HOPE mass spectrometer onboard the Van Allen Probes measures energetic hydrogen, helium, and oxygen ions near the inner edge of the plasma sheet, where these ion structures are observed. We present a statistical study of nose-like structures, using 2-years measurements from the HOPE instrument. The results provide important details about the spatial distribution (dependence on geocentric distance), spectral features of the structures (differences among species), and geomagnetic conditions under which these structures occur.

  4. Difference in thermodynamics between two types of esophageal temperature probes: Insights from an experimental study.

    PubMed

    Gianni, Carola; Atoui, Moustapha; Mohanty, Sanghamitra; Trivedi, Chintan; Bai, Rong; Al-Ahmad, Amin; Burkhardt, J David; Gallinghouse, G Joseph; Hranitzky, Patrick M; Horton, Rodney P; Sanchez, Javier E; Di Biase, Luigi; Lakkireddy, Dhanunjaya R; Natale, Andrea

    2016-11-01

    Luminal esophageal temperature monitoring is performed with a variety of temperature probes, but little is known about the relationship between the structure of a given probe and its thermodynamic characteristics. The purpose of this study was to evaluate the difference in thermodynamics between a 9Fr standard esophageal probe and an 18Fr esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42°C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5°C ± 0.4°C vs 33.5°C ± 0.3°C, P<.0001), whereas the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s vs 38.8 ± 1.0 s, P<.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature of 39.6°C ± 0.3°C, the esophageal stethoscope still displayed a temperature of 37.3°C ± 0.2°C (a mean of 2.39°C ± 0.3°C lower, P<.0001), showing a <0.5°C increase in temperature half of the times. The 18Fr esophageal stethoscope has a significantly slower time response compared to the 9Fr esophageal probe. In the clinical setting, this might result in a considerable underestimation of the luminal esophageal temperature with potentially fatal consequences. Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  5. Characterization of Akiyama probe applied to dual-probes atomic force microscope

    NASA Astrophysics Data System (ADS)

    Wang, Hequn; Gao, Sitian; Li, Wei; Shi, Yushu; Li, Qi; Li, Shi; Zhu, Zhendong

    2016-10-01

    The measurement of nano-scale line-width has always been important and difficult in the field of nanometer measurements, while the rapid development of integrated circuit greatly raises the demand again. As one kind of scanning probe microscope (SPM), atomic force microscope (AFM) can realize quasi three-dimensional measurement, which is widely used in nanometer scale line-width measurement. Our team researched a dual-probes atomic force microscope, which can eliminate the prevalent effect of probe width on measurement results. In dual-probes AFM system, a novel head are newly designed. A kind of self-sensing and self-exciting probes which is Nanosensors cooperation's patented probe—Akiyama probe, is used in this novel head. The Akiyama probe applied to dual-probe atomic force microscope is one of the most important issues. The characterization of Akiyama probe would affect performance and accuracy of the whole system. The fundamental features of the Akiyama probe are electrically and optically characterized in "approach-withdraw" experiments. Further investigations include the frequency response of an Akiyama probe to small mechanical vibrations externally applied to the tip and the effective loading force yielding between the tip and the sample during the periodic contact. We hope that the characterization of the Akiyama probe described in this paper will guide application for dual-probe atomic force microscope.

  6. MABE multibeam accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hasti, D.E.; Ramirez, J.J.; Coleman, P.D.

    1985-01-01

    The Megamp Accelerator and Beam Experiment (MABE) was the technology development testbed for the multiple beam, linear induction accelerator approach for Hermes III, a new 20 MeV, 0.8 MA, 40 ns accelerator being developed at Sandia for gamma-ray simulation. Experimental studies of a high-current, single-beam accelerator (8 MeV, 80 kA), and a nine-beam injector (1.4 MeV, 25 kA/beam) have been completed, and experiments on a nine-beam linear induction accelerator are in progress. A two-beam linear induction accelerator is designed and will be built as a gamma-ray simulator to be used in parallel with Hermes III. The MABE pulsed power systemmore » and accelerator for the multiple beam experiments is described. Results from these experiments and the two-beam design are discussed. 11 refs., 6 figs.« less

  7. How to study picosecond solvation dynamics using fluorescent probes with small Stokes shifts

    NASA Astrophysics Data System (ADS)

    Silori, Yogita; Dey, Shivalee; De, Arijit K.

    2018-02-01

    Xanthene dyes have wide ranging applications as fluorescent probes in analytical, biochemical and medical contexts. Being cationic/anionic in nature, the solvation dynamics of xanthene dyes confined within a negatively/positively charged interface are very interesting. Unfortunately, the floppy structure and small Stokes shift render any xanthene dye unsuitable for use as a solvation probe. Using di-sodium fluorescein, we present our work on the picosecond solvation dynamics of bulk and confined water (at pH = 9.2). We also propose a new methodology for studying picosecond solvation dynamics using any fluorescent dye with a small Stokes shift. We discuss how scattering contributions can be effectively removed, and propose an alternative way of defining zero time of solvation. Finally, we demonstrate the tuning location of the probe within confinement.

  8. Study of polarization properties of fiber-optics probes with use of a binary phase plate.

    PubMed

    Alferov, S V; Khonina, S N; Karpeev, S V

    2014-04-01

    We conduct a theoretical and experimental study of the distribution of the electric field components in the sharp focal domain when rotating a zone plate with a π-phase jump placed in the focused beam. Comparing the theoretical and experimental results for several kinds of near-field probes, an analysis of the polarization sensitivity of different types of metal-coated aperture probes is conducted. It is demonstrated that with increasing diameter of the non-metal-coated tip part there occurs an essential redistribution of sensitivity in favor of the transverse electric field components and an increase of the probe's energy throughput.

  9. Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution. 2: Polycondensations

    NASA Technical Reports Server (NTRS)

    Kolb, Vera; Orgel, Leslie E.

    1995-01-01

    We have prepared a (P-32)-labeled oligonucleotide probe carrying a ureido (-NH-CO-NH2) function at its 3'-terminus. This labeled oligomer was used to study polycondensations of urea and formaldehyde and of various phenols and formaldehyde in aqueous solution. The formation of formaldehyde copolymers attached to the amido-function of the probe was monitored by gel electrophoresis. Our results are generally in agreement with those obtained using conventional techniques. Our method is suitable for monitoring potentially prebiotic polycondensation reactions involving formaldehyde.

  10. Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution: II. Polycondensations

    NASA Technical Reports Server (NTRS)

    Kolb, V.; Orgel, L. E.

    1995-01-01

    We have prepared a [32P]-labeled oligonucleotide probe carrying a ureido (-NH-CO-NH2) function at its 3'-terminus. This labeled oligomer was used to study polycondensations of urea and formaldehyde and of various phenols and formaldehyde in aqueous solution. The formation of formaldehyde copolymers attached to the amido-function of the probe was monitored by gel electrophoresis. Our results are generally in agreement with those obtained using conventional techniques. Our method is suitable for monitoring potentially prebiotic polycondensation reactions involving formaldehyde.

  11. Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.

    PubMed

    Aron, Allegra T; Ramos-Torres, Karla M; Cotruvo, Joseph A; Chang, Christopher J

    2015-08-18

    Metals are essential for life, playing critical roles in all aspects of the central dogma of biology (e.g., the transcription and translation of nucleic acids and synthesis of proteins). Redox-inactive alkali, alkaline earth, and transition metals such as sodium, potassium, calcium, and zinc are widely recognized as dynamic signals, whereas redox-active transition metals such as copper and iron are traditionally thought of as sequestered by protein ligands, including as static enzyme cofactors, in part because of their potential to trigger oxidative stress and damage via Fenton chemistry. Metals in biology can be broadly categorized into two pools: static and labile. In the former, proteins and other macromolecules tightly bind metals; in the latter, metals are bound relatively weakly to cellular ligands, including proteins and low molecular weight ligands. Fluorescent probes can be useful tools for studying the roles of transition metals in their labile forms. Probes for imaging transition metal dynamics in living systems must meet several stringent criteria. In addition to exhibiting desirable photophysical properties and biocompatibility, they must be selective and show a fluorescence turn-on response to the metal of interest. To meet this challenge, we have pursued two general strategies for metal detection, termed "recognition" and "reactivity". Our design of transition metal probes makes use of a recognition-based approach for copper and nickel and a reactivity-based approach for cobalt and iron. This Account summarizes progress in our laboratory on both the development and application of fluorescent probes to identify and study the signaling roles of transition metals in biology. In conjunction with complementary methods for direct metal detection and genetic and/or pharmacological manipulations, fluorescent probes for transition metals have helped reveal a number of principles underlying transition metal dynamics. In this Account, we give three recent

  12. DIFFUSIVE SHOCK ACCELERATION SIMULATIONS OF RADIO RELICS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kang, Hyesung; Ryu, Dongsu; Jones, T. W., E-mail: kang@uju.es.pusan.ac.kr, E-mail: ryu@canopus.cnu.ac.kr, E-mail: twj@msi.umn.edu

    2012-09-01

    Recent radio observations have identified a class of structures, so-called radio relics, in clusters of galaxies. The radio emission from these sources is interpreted as synchrotron radiation from GeV electrons gyrating in {mu}G-level magnetic fields. Radio relics, located mostly in the outskirts of clusters, seem to associate with shock waves, especially those developed during mergers. In fact, they seem to be good structures to identify and probe such shocks in intracluster media (ICMs), provided we understand the electron acceleration and re-acceleration at those shocks. In this paper, we describe time-dependent simulations for diffusive shock acceleration at weak shocks that aremore » expected to be found in ICMs. Freshly injected as well as pre-existing populations of cosmic-ray (CR) electrons are considered, and energy losses via synchrotron and inverse Compton are included. We then compare the synchrotron flux and spectral distributions estimated from the simulations with those in two well-observed radio relics in CIZA J2242.8+5301 and ZwCl0008.8+5215. Considering that CR electron injection is expected to be rather inefficient at weak shocks with Mach number M {approx}< a few, the existence of radio relics could indicate the pre-existing population of low-energy CR electrons in ICMs. The implication of our results on the merger shock scenario of radio relics is discussed.« less

  13. Study of modification methods of probes for critical-dimension atomic-force microscopy by the deposition of carbon nanotubes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ageev, O. A., E-mail: ageev@sfedu.ru; Bykov, Al. V.; Kolomiitsev, A. S.

    2015-12-15

    The results of an experimental study of the modification of probes for critical-dimension atomicforce microscopy (CD-AFM) by the deposition of carbon nanotubes (CNTs) to improve the accuracy with which the surface roughness of vertical walls is determined in submicrometer structures are presented. Methods of the deposition of an individual CNT onto the tip of an AFM probe via mechanical and electrostatic interaction between the probe and an array of vertically aligned carbon nanotubes (VACNTs) are studied. It is shown that, when the distance between the AFM tip and a VACNT array is 1 nm and the applied voltage is withinmore » the range 20–30 V, an individual carbon nanotube is deposited onto the tip. On the basis of the results obtained in the study, a probe with a carbon nanotube on its tip (CNT probe) with a radius of 7 nm and an aspect ratio of 1:15 is formed. Analysis of the CNT probe demonstrates that its use improves the resolution and accuracy of AFM measurements, compared with the commercial probe, and also makes it possible to determine the roughness of the vertical walls of high-aspect structures by CD-AFM. The results obtained can be used to develop technological processes for the fabrication and reconditioning of special AFM probes, including those for CD-AFM, and procedures for the interoperational express monitoring of technological process parameters in the manufacturing of elements for micro- and nanoelectronics and micro- and nanosystem engineering.« less

  14. A Coaxial Dual-element Focused Ultrasound Probe for Guidance of Epidural Catheterization: An Experimental Study.

    PubMed

    Dong, Guo-Chung; Chiu, Li-Chen; Ting, Chien-Kun; Hsu, Jia-Ruei; Huang, Chih-Chung; Chang, Yin; Chen, Gin-Shin

    2017-09-01

    Ultrasound guidance for epidural block has improved clinical blind-trial problems but the design of present ultrasonic probes poses operating difficulty of ultrasound-guided catheterization, increasing the failure rate. The purpose of this study was to develop a novel ultrasonic probe to avoid needle contact with vertebral bone during epidural catheterization. The probe has a central circular passage for needle insertion. Two focused annular transducers are deployed around the passage for on-axis guidance. A 17-gauge insulated Tuohy needle containing the self-developed fiber-optic-modified stylet was inserted into the back of the anesthetized pig, in the lumbar region under the guidance of our ultrasonic probe. The inner transducer of the probe detected the shallow echo signals of the peak-peak amplitude of 2.8 V over L3 at the depth of 2.4 cm, and the amplitude was decreased to 0.8 V directly over the L3 to L4 interspace. The outer transducer could detect the echoes from the deeper bone at the depth of 4.5 cm, which did not appear for the inner transducer. The operator tilted the probe slightly in left-right and cranial-caudal directions until the echoes at the depth of 4.5 cm disappeared, and the epidural needle was inserted through the central passage of the probe. The needle was advanced and stopped when the epidural space was identified by optical technique. The needle passed without bone contact. Designs of the hollow probe for needle pass and dual transducers with different focal lengths for detection of shallow and deep vertebrae may benefit operation, bone/nonbone identification, and cost.

  15. Four-probe measurements with a three-probe scanning tunneling microscope

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Salomons, Mark; Martins, Bruno V. C.; Zikovsky, Janik

    2014-04-15

    We present an ultrahigh vacuum (UHV) three-probe scanning tunneling microscope in which each probe is capable of atomic resolution. A UHV JEOL scanning electron microscope aids in the placement of the probes on the sample. The machine also has a field ion microscope to clean, atomically image, and shape the probe tips. The machine uses bare conductive samples and tips with a homebuilt set of pliers for heating and loading. Automated feedback controlled tip-surface contacts allow for electrical stability and reproducibility while also greatly reducing tip and surface damage due to contact formation. The ability to register inter-tip position bymore » imaging of a single surface feature by multiple tips is demonstrated. Four-probe material characterization is achieved by deploying two tips as fixed current probes and the third tip as a movable voltage probe.« less

  16. Four-probe measurements with a three-probe scanning tunneling microscope.

    PubMed

    Salomons, Mark; Martins, Bruno V C; Zikovsky, Janik; Wolkow, Robert A

    2014-04-01

    We present an ultrahigh vacuum (UHV) three-probe scanning tunneling microscope in which each probe is capable of atomic resolution. A UHV JEOL scanning electron microscope aids in the placement of the probes on the sample. The machine also has a field ion microscope to clean, atomically image, and shape the probe tips. The machine uses bare conductive samples and tips with a homebuilt set of pliers for heating and loading. Automated feedback controlled tip-surface contacts allow for electrical stability and reproducibility while also greatly reducing tip and surface damage due to contact formation. The ability to register inter-tip position by imaging of a single surface feature by multiple tips is demonstrated. Four-probe material characterization is achieved by deploying two tips as fixed current probes and the third tip as a movable voltage probe.

  17. Chimpanzees create and modify probe tools functionally: A study with zoo-housed chimpanzees

    PubMed Central

    Hopper, Lydia M; Tennie, Claudio; Ross, Stephen R; Lonsdorf, Elizabeth V

    2015-01-01

    Chimpanzees (Pan troglodytes) use tools to probe for out-of-reach food, both in the wild and in captivity. Beyond gathering appropriately-sized materials to create tools, chimpanzees also perform secondary modifications in order to create an optimized tool. In this study, we recorded the behavior of a group of zoo-housed chimpanzees when presented with opportunities to use tools to probe for liquid foods in an artificial termite mound within their enclosure. Previous research with this group of chimpanzees has shown that they are proficient at gathering materials from within their environment in order to create tools to probe for the liquid food within the artificial mound. Extending beyond this basic question, we first asked whether they only made and modified probe tools when it was appropriate to do so (i.e. when the mound was baited with food). Second, by collecting continuous data on their behavior, we also asked whether the chimpanzees first (intentionally) modified their tools prior to probing for food or whether such modifications occurred after tool use, possibly as a by-product of chewing and eating the food from the tools. Following our predictions, we found that tool modification predicted tool use; the chimpanzees began using their tools within a short delay of creating and modifying them, and the chimpanzees performed more tool modifying behaviors when food was available than when they could not gain food through the use of probe tools. We also discuss our results in terms of the chimpanzees’ acquisition of the skills, and their flexibility of tool use and learning. Am. J. Primatol. 77:162–170, 2015. © 2014 The Authors. American Journal of Primatology Published by Wiley Periodicals Inc. PMID:25220050

  18. NeuroMEMS: Neural Probe Microtechnologies

    PubMed Central

    HajjHassan, Mohamad; Chodavarapu, Vamsy; Musallam, Sam

    2008-01-01

    Neural probe technologies have already had a significant positive effect on our understanding of the brain by revealing the functioning of networks of biological neurons. Probes are implanted in different areas of the brain to record and/or stimulate specific sites in the brain. Neural probes are currently used in many clinical settings for diagnosis of brain diseases such as seizers, epilepsy, migraine, Alzheimer's, and dementia. We find these devices assisting paralyzed patients by allowing them to operate computers or robots using their neural activity. In recent years, probe technologies were assisted by rapid advancements in microfabrication and microelectronic technologies and thus are enabling highly functional and robust neural probes which are opening new and exciting avenues in neural sciences and brain machine interfaces. With a wide variety of probes that have been designed, fabricated, and tested to date, this review aims to provide an overview of the advances and recent progress in the microfabrication techniques of neural probes. In addition, we aim to highlight the challenges faced in developing and implementing ultra-long multi-site recording probes that are needed to monitor neural activity from deeper regions in the brain. Finally, we review techniques that can improve the biocompatibility of the neural probes to minimize the immune response and encourage neural growth around the electrodes for long term implantation studies. PMID:27873894

  19. Accelerator system and method of accelerating particles

    NASA Technical Reports Server (NTRS)

    Wirz, Richard E. (Inventor)

    2010-01-01

    An accelerator system and method that utilize dust as the primary mass flux for generating thrust are provided. The accelerator system can include an accelerator capable of operating in a self-neutralizing mode and having a discharge chamber and at least one ionizer capable of charging dust particles. The system can also include a dust particle feeder that is capable of introducing the dust particles into the accelerator. By applying a pulsed positive and negative charge voltage to the accelerator, the charged dust particles can be accelerated thereby generating thrust and neutralizing the accelerator system.

  20. Scattering of accelerated wave packets

    NASA Astrophysics Data System (ADS)

    Longhi, S.; Horsley, S. A. R.; Della Valle, G.

    2018-03-01

    Wave-packet scattering from a stationary potential is significantly modified when the wave packet is subject to an external time-dependent force during the interaction. In the semiclassical limit, wave-packet motion is simply described by Newtonian equations, and the external force can, for example, cancel the potential force, making a potential barrier transparent. Here we consider wave-packet scattering from reflectionless potentials, where in general the potential becomes reflective when probed by an accelerated wave packet. In the particular case of the recently introduced class of complex Kramers-Kronig potentials we show that a broad class of time-dependent forces can be applied without inducing any scattering, while there is a breakdown of the reflectionless property when there is a broadband distribution of initial particle momentum, involving both positive and negative components.

  1. Staging of laser-plasma accelerators

    DOE PAGES

    Steinke, S.; van Tilborg, J.; Benedetti, C.; ...

    2016-05-02

    We present results of an experiment where two laser-plasma-accelerator stages are coupled at a short distance by a plasma mirror. Stable electron beams from the first stage were used to longitudinally probe the dark-current-free, quasi-linear wakefield excited by the laser of the second stage. Changing the arrival time of the electron beam with respect to the second stage laser pulse allowed reconstruction of the temporal wakefield structure, determination of the plasma density, and inference of the length of the electron beam. The first stage electron beam could be focused by an active plasma lens to a spot size smaller thanmore » the transverse wake size at the entrance of the second stage. Furthermore, this permitted electron beam trapping, verified by a 100 MeV energy gain.« less

  2. Unravelling RNA-substrate interactions in a ribozyme-catalysed reaction using fluorescent turn-on probes.

    PubMed

    Gaffarogullari, Ece Cazibe; Greulich, Peter; Kobitski, Andrei Yu; Nierth, Alexander; Nienhaus, G Ulrich; Jäschke, Andres

    2015-04-07

    The Diels-Alder reaction is one of the most important C-C bond-forming reactions in organic chemistry, and much effort has been devoted to controlling its enantio- and diastereoselectivity. The Diels-Alderase ribozyme (DAse) catalyses the reaction between anthracene dienes and maleimide dienophiles with multiple-turnover, stereoselectivity, and up to 1100-fold rate acceleration. Here, a new generation of anthracene-BODIPY-based fluorescent probes was developed to monitor catalysis by the DAse. The brightness of these probes increases up to 93-fold upon reaction with N-pentylmaleimide (NPM), making these useful tools for investigating the stereochemistry of the ribozyme-catalysed reaction. With these probes, we observed that the DAse catalyses the reaction with >91% de and >99% ee. The stereochemistry of the major product was determined unambiguously by rotating-frame nuclear Overhauser NMR spectroscopy (ROESY-NMR) and is in agreement with crystallographic structure information. The pronounced fluorescence change of the probes furthermore allowed a complete kinetic analysis, which revealed an ordered bi uni type reaction mechanism, with the dienophile binding first. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Study of complex molecular systems by probe vibrational spectroscopy method

    NASA Astrophysics Data System (ADS)

    Boldeskul, A. E.; Zatsepin, V. M.; Atakhodjaev, A. K.; Shermatov, A. N.; Ashburiev, R.

    1984-03-01

    Experimental study of benzonitril as a probe in aqueous solution of sodium lauril sulphate /SDS/ by Raman spectroscopy technique showed integral moments of √ /C X N/ line to be extremely sensitive to the structural transitions in micellar systems. The central part of the experimental contour was used to determine integral moments with the help of line shape approximant received by Mori method

  4. Development of endovascular vibrating polymer actuator probe for mechanical thrombolysis: a phantom study.

    PubMed

    Choi, Seung Hong; Yoon, Bye-Ri; Oh, Jin Sun; Han, Moon Hee; Lee, Jang Yeol; Cho, Hye Rim; Kim, Moon June; Rhee, Kyehan; Jho, Jae Young

    2011-01-01

    In this study, we propose a new method for enhancement of intraarterial thrombolysis using an ionic polymer-metal composite (IPMC) actuator. The purpose of this study was to test the mechanical thrombolysis efficiency of IPMC actuators and evaluate the endovascular vibrating polymer actuator probe for mechanical thrombolysis in a phantom model; 2 × 1 × 15 mm (2 mm in width, 1 mm in thickness, and 15 mm in length) and 0.8 × 0.8 × 10 mm (0.8 mm in width, 0.8 mm in thickness, and 10 mm in length) IPMC actuators were fabricated by stacking five and four Nafion-117 films, respectively. We manufactured the endovascular vibrating polymer actuator probe, for which thrombolysis efficiency was tested in a vascular phantom. The phantom study using 2 × 1 × 15 mm IPMC actuators showed that 5 Hz actuation is the optimal frequency for thrombolysis under both 2 and 3 V, when blood clot was not treated with rtPA, and when exposed to rtPA, IPMC actuators under the optimized condition (3 V, 5 Hz, and 5 min) significantly increased the thrombolysis degree compared with control and other experimental groups (p < 0.05). In addition, 0.8 × 0.8 × 10 mm IPMC actuators also revealed a significantly higher thrombolysis degree under the optimized condition than the control and rtPA only groups (p < 0.05). Finally, the fabricated probe using 0.8 × 0.8 × 10 mm IPMC actuators also incurred higher thrombolysis degree under the optimized condition than the control and rtPA only groups (p < 0.05). A vibrating polymer actuator probe is a feasible device for intravascular thrombolysis, and further study in an animal model is warranted.

  5. Fundamental Study on One-Dimensional-Array Medical Ultrasound Probe with Piezoelectric Polycrystalline Film by Hydrothermal Method: Experimental Fabrication of One-Dimensional-Array Ultrasound Probe

    NASA Astrophysics Data System (ADS)

    Endo, Akito; Kawashima, Norimichi; Takeuchi, Shinichi; Ishikawa, Mutsuo; Kurosawa, Minoru Kuribayashi

    2007-07-01

    We deposited a lead zirconate titanete (PZT) polycrystalline film on a titanium substrate by the hydrothermal method and fabricated a transducer using the PZT film for use as an ultrasound probe. A 10 MHz miniature one-dimensional-array medical ultrasound probe containing the PZT film was developed. After sputtering titanium on the surface of a hydroxyapatite substrate, the titanium film on the substrate was etched by the photolithography to form a one-dimensional titanium film electrode array. We could thus fabricate a miniature one-dimensional-array ultrasound probe by the hydrothermal method. Transmitted ultrasound pulses from a 10 MHz commercial ultrasound probe were received by the newly fabricated one-dimensional-array ultrasound probe. The fabrication process of the probe and the results of experiments on receiving waveforms were reported in this paper.

  6. Frequency-Domain Streak Camera and Tomography for Ultrafast Imaging of Evolving and Channeled Plasma Accelerator Structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li Zhengyan; Zgadzaj, Rafal; Wang Xiaoming

    2010-11-04

    We demonstrate a prototype Frequency Domain Streak Camera (FDSC) that can capture the picosecond time evolution of the plasma accelerator structure in a single shot. In our prototype Frequency-Domain Streak Camera, a probe pulse propagates obliquely to a sub-picosecond pump pulse that creates an evolving nonlinear index 'bubble' in fused silica glass, supplementing a conventional Frequency Domain Holographic (FDH) probe-reference pair that co-propagates with the 'bubble'. Frequency Domain Tomography (FDT) generalizes Frequency-Domain Streak Camera by probing the 'bubble' from multiple angles and reconstructing its morphology and evolution using algorithms similar to those used in medical CAT scans. Multiplexing methods (Temporalmore » Multiplexing and Angular Multiplexing) improve data storage and processing capability, demonstrating a compact Frequency Domain Tomography system with a single spectrometer.« less

  7. Electron paramagnetic resonance studies of slowly tumbling vanadyl spin probes in nematic liquid crystals

    NASA Technical Reports Server (NTRS)

    Bruno, G. V.; Harrington, J. K.; Eastman, M. P.

    1978-01-01

    The purposes of this vanadyl spin probe study are threefold: (1) to establish when the breakdown of motionally narrowed formulas occurs; (2) to analyze the experimental vanadyl EPR line shapes by the stochastic Lioville method as developed by Polnaszek et al. (1973) for slow tumbling in an anisotropic liquid; and (3) to compare the vanadyl probe study results with those of Polnaszek and Freed (1975). Spectral EPR line shapes are simulated for experimental spectra of vanadyl acetylacetonate (VOAA) in nematic liquid crystal butyl p-(p-ethoxyphenoxycarbonyl) phenyl carbonate (BEPC) and Phase V of EM laboratories. It is shown that the use of typical vanadyl complexes as spin probes for nematic liquid crystals simplifies the theoretical analysis and the subsequent interpretation. Guidelines for the breakdown of motionally narrowed formulas are established. Both the slow tumbling aspects and the effects of non-Brownian rotation should be resolved in order to extract quantitative information about molecular ordering and rotational mobility.

  8. Fluorescent hybridization probes for nucleic acid detection.

    PubMed

    Guo, Jia; Ju, Jingyue; Turro, Nicholas J

    2012-04-01

    Due to their high sensitivity and selectivity, minimum interference with living biological systems, and ease of design and synthesis, fluorescent hybridization probes have been widely used to detect nucleic acids both in vivo and in vitro. Molecular beacons (MBs) and binary probes (BPs) are two very important hybridization probes that are designed based on well-established photophysical principles. These probes have shown particular applicability in a variety of studies, such as mRNA tracking, single nucleotide polymorphism (SNP) detection, polymerase chain reaction (PCR) monitoring, and microorganism identification. Molecular beacons are hairpin oligonucleotide probes that present distinctive fluorescent signatures in the presence and absence of their target. Binary probes consist of two fluorescently labeled oligonucleotide strands that can hybridize to adjacent regions of their target and generate distinctive fluorescence signals. These probes have been extensively studied and modified for different applications by modulating their structures or using various combinations of fluorophores, excimer-forming molecules, and metal complexes. This review describes the applicability and advantages of various hybridization probes that utilize novel and creative design to enhance their target detection sensitivity and specificity.

  9. Microstrip antenna study for Pioneer Saturn/Uranus atmosphere entry probe

    NASA Technical Reports Server (NTRS)

    Kuhlman, E. A.

    1974-01-01

    The design parameters of a microstrip antenna were studied to determine its performance characteristics as affected by an atmospheric entry probe environment. The technical literature was reviewed to identify the known design and performance characteristics. These data were used to evaluate the expected effects of mission environments on the microstrip antenna design proposed for the Saturn/Uranus Atmospheric Entry Probe (SAEP). Radiation patterns and VSWR measurements were made to evaluate the performance in the SAEP thermal environment. Results of the literature search and pattern tests confirm that the microstrip antenna is a good choice as a transmitting antenna on the SAEP. The microstrip antenna is efficient, compact, and well suited to a space environment. The pattern can be controlled with a minimum beamwidth of 60 degrees (air substrate; e.g., honeycomb structure) and a maximum on the order of 100 degrees with higher dielectric constant substrates. The power handling capacity is good and can be improved by covering the antenna with a dielectric cover.

  10. Signature energetic analysis of accelerate electron beam after first acceleration station by accelerating stand of Joint Institute for Nuclear Research

    NASA Astrophysics Data System (ADS)

    Sledneva, A. S.; Kobets, V. V.

    2017-06-01

    The linear electron accelerator based on the LINAC - 800 accelerator imported from the Netherland is created at Joint Institute for Nuclear Research in the framework of the project on creation of the Testbed with an electron beam of a linear accelerator with an energy up to 250 MV. Currently two accelerator stations with a 60 MV energy of a beam are put in operation and the work is to put the beam through accelerating section of the third accelerator station. The electron beam with an energy of 23 MeV is used for testing the crystals (BaF2, CsI (native), and LYSO) in order to explore the opportunity to use them in particle detectors in experiments: Muon g-2, Mu2e, Comet, whose preparation requires a detailed study of the detectors properties such as their irradiation by the accelerator beams.

  11. Scanning MWCNT-Nanopipette and Probe Microscopy: Li Patterning and Transport Studies.

    PubMed

    Larson, Jonathan M; Bharath, Satyaveda C; Cullen, William G; Reutt-Robey, Janice E

    2015-10-07

    A carbon-nanotube-enabling scanning probe technique/nanotechnology for manipulating and measuring lithium at the nano/mesoscale is introduced. Scanning Li-nanopipette and probe microscopy (SLi-NPM) is based on a conductive atomic force microscope (AFM) cantilever with an open-ended multi-walled carbon nanotube (MWCNT) affixed to its apex. SLi-NPM operation is demonstrated with a model system consisting of a Li thin film on a Si(111) substrate. By control of bias, separation distance, and contact time, attograms of Li can be controllably pipetted to or from the MWCNT tip. Patterned surface Li features are then directly probed via noncontact AFM measurements with the MWCNT tip. The subsequent decay of Li features is simulated with a mesoscale continuum model, developed here. The Li surface diffusion coefficient for a four (two) Li layer thick film is measured as D=8(±1.2)×10(-15) cm(2) s(-1) (D=1.75(±0.15)×10(-15) cm(2) s(-1)). Dual-Li pipetting/measuring with SLi-NPM enables a broad range of time-dependent Li and nanoelectrode characterization studies of fundamental importance to energy-storage research. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Where do pulse oximeter probes break?

    PubMed

    Crede, S; Van der Merwe, G; Hutchinson, J; Woods, D; Karlen, W; Lawn, J

    2014-06-01

    Pulse oximetry, a non-invasive method for accurate assessment of blood oxygen saturation (SPO2), is an important monitoring tool in health care facilities. However, it is often not available in many low-resource settings, due to expense, overly sophisticated design, a lack of organised procurement systems and inadequate medical device management and maintenance structures. Furthermore medical devices are often fragile and not designed to withstand the conditions of low-resource settings. In order to design a probe, better suited to the needs of health care facilities in low-resource settings this study aimed to document the site and nature of pulse oximeter probe breakages in a range of different probe designs in a low to middle income country. A retrospective review of job cards relating to the assessment and repair of damaged or faulty pulse oximeter probes was conducted at a medical device repair company based in Cape Town, South Africa, specializing in pulse oximeter probe repairs. 1,840 job cards relating to the assessment and repair of pulse oximeter probes were reviewed. 60.2 % of probes sent for assessment were finger-clip probes. For all probes, excluding the neonatal wrap probes, the most common point of failure was the probe wiring (>50 %). The neonatal wrap most commonly failed at the strap (51.5 %). The total cost for quoting on the broken pulse oximeter probes and for the subsequent repair of devices, excluding replacement components, amounted to an estimated ZAR 738,810 (USD $98,508). Improving the probe wiring would increase the life span of pulse oximeter probes. Increasing the life span of probes will make pulse oximetry more affordable and accessible. This is of high priority in low-resource settings where frequent repair or replacement of probes is unaffordable or impossible.

  13. Hard probes of short-range nucleon-nucleon correlations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. Arrington, D. W. Higinbotham, G. Rosner, M. Sargsian

    2012-10-01

    The strong interaction of nucleons at short distances leads to a high-momentum component to the nuclear wave function, associated with short-range correlations between nucleons. These short-range, high-momentum structures in nuclei are one of the least well understood aspects of nuclear matter, relating to strength outside of the typical mean-field approaches to calculating the structure of nuclei. While it is difficult to study these short-range components, significant progress has been made over the last decade in determining how to cleanly isolate short-range correlations in nuclei. We have moved from asking if such structures exist, to mapping out their strength in nucleimore » and studying their microscopic structure. A combination of several different measurements, made possible by high-luminosity and high-energy accelerators, coupled with an improved understanding of the reaction mechanism issues involved in studying these structures, has led to significant progress, and provided significant new information on the nature of these small, highly-excited structures in nuclei. We review the general issues related to short-range correlations, survey recent experiments aimed at probing these short-range structures, and lay out future possibilities to further these studies.« less

  14. Microfluidics for Positron Emission Tomography (PET) Imaging Probe Development

    PubMed Central

    Wang, Ming-Wei; Lin, Wei-Yu; Liu, Kan; Masterman-Smith, Michael; Shen, Clifton Kwang-Fu

    2012-01-01

    Due to increased needs for Positron Emission Tomography (PET) scanning, high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional labeling systems. Microfluidic-based radiochemistry can lead to the use of smaller quantities of precursors, accelerated reaction rates and easier purification processes with greater yield and higher specific activity of desired probes. Several ‘proof-of-principle’ examples, along with basics of device architecture and operation, and potential limitations of each design are discussed here. Along with the concept of radioisotope distribution from centralized cyclotron facilities to individual imaging centers and laboratories (“decentralized model”), an easy-to-use, standalone, flexible, fully-automated radiochemical microfluidic platform can open up to simpler and more cost-effective procedures for molecular imaging using PET. PMID:20643021

  15. Traversing probe system

    DOEpatents

    Mashburn, Douglas N.; Stevens, Richard H.; Woodall, Harold C.

    1977-01-01

    This invention comprises a rotatable annular probe-positioner which carries at least one radially disposed sensing probe, such as a Pitot tube having a right-angled tip. The positioner can be coaxially and rotatably mounted within a compressor casing or the like and then actuated to orient the sensing probe as required to make measurements at selected stations in the annulus between the positioner and compressor casing. The positioner can be actuated to (a) selectively move the probe along its own axis, (b) adjust the yaw angle of the right-angled probe tip, and (c) revolve the probe about the axis common to the positioner and casing. A cam plate engages a cam-follower portion of the probe and normally rotates with the positioner. The positioner includes a first-motor-driven ring gear which effects slidable movement of the probe by rotating the positioner at a time when an external pneumatic cylinder is actuated to engage the cam plate and hold it stationary. When the pneumatic cylinder is not actuated, this ring gear can be driven to revolve the positioner and thus the probe to a desired circumferential location about the above-mentioned common axis. A second motor-driven ring gear included in the positioner can be driven to rotate the probe about its axis, thus adjusting the yaw angle of the probe tip. The positioner can be used in highly corrosive atmosphere, such as gaseous uranium hexafluoride.

  16. Ice-Borehole Probe

    NASA Technical Reports Server (NTRS)

    Behar, Alberto; Carsey, Frank; Lane, Arthur; Engelhardt, Herman

    2006-01-01

    An instrumentation system has been developed for studying interactions between a glacier or ice sheet and the underlying rock and/or soil. Prior borehole imaging systems have been used in well-drilling and mineral-exploration applications and for studying relatively thin valley glaciers, but have not been used for studying thick ice sheets like those of Antarctica. The system includes a cylindrical imaging probe that is lowered into a hole that has been bored through the ice to the ice/bedrock interface by use of an established hot-water-jet technique. The images acquired by the cameras yield information on the movement of the ice relative to the bedrock and on visible features of the lower structure of the ice sheet, including ice layers formed at different times, bubbles, and mineralogical inclusions. At the time of reporting the information for this article, the system was just deployed in two boreholes on the Amery ice shelf in East Antarctica and after successful 2000 2001 deployments in 4 boreholes at Ice Stream C, West Antarctica, and in 2002 at Black Rapids Glacier, Alaska. The probe is designed to operate at temperatures from 40 to +40 C and to withstand the cold, wet, high-pressure [130-atm (13.20-MPa)] environment at the bottom of a water-filled borehole in ice as deep as 1.6 km. A current version is being outfitted to service 2.4-km-deep boreholes at the Rutford Ice Stream in West Antarctica. The probe (see figure) contains a sidelooking charge-coupled-device (CCD) camera that generates both a real-time analog video signal and a sequence of still-image data, and contains a digital videotape recorder. The probe also contains a downward-looking CCD analog video camera, plus halogen lamps to illuminate the fields of view of both cameras. The analog video outputs of the cameras are converted to optical signals that are transmitted to a surface station via optical fibers in a cable. Electric power is supplied to the probe through wires in the cable at a

  17. Study of possible solar heating effects on thermosonde probes: Error analysis

    NASA Astrophysics Data System (ADS)

    Brown, James H.; Dewan, Edmond; Murphy, Edmund; Thomas, Peter

    1989-07-01

    Thermosonde data reveals a diurnal daytime shift in measured levels of C square (n) in the free atmosphere. The shift is manifested in two ways. First, an apparent offset in the smallest measured values of C square (n) exists. Secondly, the curve of the average profile shows an enhancement over nighttime profiles. Related optical and radar measurements have indicated that differences between day and night probably exist, but because of limited instrumental resolution and altitude capabilities those results are inconclusive. Several hypotheses were put forward concerning possible instrumental or solar based sources of data contamination. The possibility was examined that solar radiation causes probe heating with subsequent instrumental effects. Calculation, computer simulation, and direct measurements have shown that the sun heats the body of the probe sensor a couple of degrees above the ambient and that the level of heating depends upon the solar aspect angle and magnitude and direction of air flow over the probe. A small but insignificant ac type effect can result from improper probe geometry or probe mismatch together with a coupling of solar heating with velocity turbulence. Transient and dc type effects can occur, but measured, processed, and transmitted root mean square C square (n) information is not likely to contain instrumental contamination.

  18. Simulation of diatomic gas-wall interaction and accommodation coefficients for negative ion sources and accelerators.

    PubMed

    Sartori, E; Brescaccin, L; Serianni, G

    2016-02-01

    Particle-wall interactions determine in different ways the operating conditions of plasma sources, ion accelerators, and beams operating in vacuum. For instance, a contribution to gas heating is given by ion neutralization at walls; beam losses and stray particle production-detrimental for high current negative ion systems such as beam sources for fusion-are caused by collisional processes with residual gas, with the gas density profile that is determined by the scattering of neutral particles at the walls. This paper shows that Molecular Dynamics (MD) studies at the nano-scale can provide accommodation parameters for gas-wall interactions, such as the momentum accommodation coefficient and energy accommodation coefficient: in non-isothermal flows (such as the neutral gas in the accelerator, coming from the plasma source), these affect the gas density gradients and influence efficiency and losses in particular of negative ion accelerators. For ideal surfaces, the computation also provides the angular distribution of scattered particles. Classical MD method has been applied to the case of diatomic hydrogen molecules. Single collision events, against a frozen wall or a fully thermal lattice, have been simulated by using probe molecules. Different modelling approximations are compared.

  19. Simulation of diatomic gas-wall interaction and accommodation coefficients for negative ion sources and accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sartori, E., E-mail: emanuele.sartori@igi.cnr.it; Serianni, G.; Brescaccin, L.

    2016-02-15

    Particle-wall interactions determine in different ways the operating conditions of plasma sources, ion accelerators, and beams operating in vacuum. For instance, a contribution to gas heating is given by ion neutralization at walls; beam losses and stray particle production—detrimental for high current negative ion systems such as beam sources for fusion—are caused by collisional processes with residual gas, with the gas density profile that is determined by the scattering of neutral particles at the walls. This paper shows that Molecular Dynamics (MD) studies at the nano-scale can provide accommodation parameters for gas-wall interactions, such as the momentum accommodation coefficient andmore » energy accommodation coefficient: in non-isothermal flows (such as the neutral gas in the accelerator, coming from the plasma source), these affect the gas density gradients and influence efficiency and losses in particular of negative ion accelerators. For ideal surfaces, the computation also provides the angular distribution of scattered particles. Classical MD method has been applied to the case of diatomic hydrogen molecules. Single collision events, against a frozen wall or a fully thermal lattice, have been simulated by using probe molecules. Different modelling approximations are compared.« less

  20. Synthetic fluorescent probes for studying copper in biological systems

    PubMed Central

    Cotruvo, Joseph A.; Aron, Allegra T.; Ramos-Torres, Karla M.; Chang, Christopher J.

    2015-01-01

    The potent redox activity of copper is required for sustaining life. Mismanagement of its cellular pools, however, can result in oxidative stress and damage connected to aging, neurodegenerative diseases, and metabolic disorders. Therefore, copper homeostasis is tightly regulated by cells and tissues. Whereas copper and other transition metal ions are commonly thought of as static cofactors buried within protein active sites, emerging data points to the presence of additional loosely bound, labile pools that can participate in dynamic signalling pathways. Against this backdrop, we review advances in sensing labile copper pools and understanding their functions using synthetic fluorescent indicators. Following brief introductions to cellular copper homeostasis and considerations in sensor design, we survey available fluorescent copper probes and evaluate their properties in the context of their utility as effective biological screening tools. We emphasize the need for combined chemical and biological evaluation of these reagents, as well as the value of complementing probe data with other techniques for characterizing the different pools of metal ions in biological systems. This holistic approach will maximize the exciting opportunities for these and related chemical technologies in the study and discovery of novel biology of metals. PMID:25692243

  1. Synthetic fluorescent probes for studying copper in biological systems.

    PubMed

    Cotruvo, Joseph A; Aron, Allegra T; Ramos-Torres, Karla M; Chang, Christopher J

    2015-07-07

    The potent redox activity of copper is required for sustaining life. Mismanagement of its cellular pools, however, can result in oxidative stress and damage connected to aging, neurodegenerative diseases, and metabolic disorders. Therefore, copper homeostasis is tightly regulated by cells and tissues. Whereas copper and other transition metal ions are commonly thought of as static cofactors buried within protein active sites, emerging data points to the presence of additional loosely bound, labile pools that can participate in dynamic signalling pathways. Against this backdrop, we review advances in sensing labile copper pools and understanding their functions using synthetic fluorescent indicators. Following brief introductions to cellular copper homeostasis and considerations in sensor design, we survey available fluorescent copper probes and evaluate their properties in the context of their utility as effective biological screening tools. We emphasize the need for combined chemical and biological evaluation of these reagents, as well as the value of complementing probe data with other techniques for characterizing the different pools of metal ions in biological systems. This holistic approach will maximize the exciting opportunities for these and related chemical technologies in the study and discovery of novel biology of metals.

  2. Final Technical Report - Nuclear Studies with Intermediate Energy Probes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Norum, Blaine

    During the almost 20 year period of this grant research was carried out on atomic nuclei and their constituents using both photons and electrons. Research was carried out at the electron accelerator facility of the Netherlands Institute for Nuclear and High Energy Physics (NIKHEFK, Amsterdam) until the electron accelerator facility was closed in 1998. Subsequently, research was carried out at the Laser-Electron Gamma Source (LEGS) of the National Synchrotron Light Source (NSLS) located at the Brookhaven National Laboratory (BNL) until the LEGS was closed at the end of 2006. During the next several years research was carried out at bothmore » the Thomas Jefferson National Accelerator Facility (JLAB) and the High Intensity Gamma Source (HIGS) of the Tri-Universities Nuclear Laboratory (TUNL) located on the campus of Duke University. Since approximately 2010 the principal focus was on research at TUNL, although analysis of data from previous research at other facilities continued. The principal early focus of the research was on the role of pions in nuclei. This was studied by studying the production of pions using both photons (at LEGS) and electrons (at NIKHEF-K and JLAB). Measurements of charged pion photoproduction from deuterium at LEGS resulted in the most interesting result of these two decades of work. By measuring the production of a charged pion (p + ) in coincidence with an emitted photon we observed structures in the residual two-nucleon system. These indicated the existence of long-lived states not explicable by standard nuclear theory; they suggest a set of configurations not explicable in terms of a nucleon-nucleon pair. The existence of such “exotic” structures has formed the foundation for most of the work that has ensued.« less

  3. The Oxford Probe: an open access five-hole probe for aerodynamic measurements

    NASA Astrophysics Data System (ADS)

    Hall, B. F.; Povey, T.

    2017-03-01

    The Oxford Probe is an open access five-hole probe designed for experimental aerodynamic measurements. The open access probe can be manufactured by the end user via additive manufacturing (metal or plastic). The probe geometry, drawings, calibration maps, and software are available under a creative commons license. The purpose is to widen access to aerodynamic measurement techniques in education and research environments. There are many situations in which the open access probe will allow results of comparable accuracy to a well-calibrated commercial probe. We discuss the applications and limitations of the probe, and compare the calibration maps for 16 probes manufactured in different materials and at different scales, but with the same geometrical design.

  4. Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems

    PubMed Central

    2015-01-01

    Conspectus Metals are essential for life, playing critical roles in all aspects of the central dogma of biology (e.g., the transcription and translation of nucleic acids and synthesis of proteins). Redox-inactive alkali, alkaline earth, and transition metals such as sodium, potassium, calcium, and zinc are widely recognized as dynamic signals, whereas redox-active transition metals such as copper and iron are traditionally thought of as sequestered by protein ligands, including as static enzyme cofactors, in part because of their potential to trigger oxidative stress and damage via Fenton chemistry. Metals in biology can be broadly categorized into two pools: static and labile. In the former, proteins and other macromolecules tightly bind metals; in the latter, metals are bound relatively weakly to cellular ligands, including proteins and low molecular weight ligands. Fluorescent probes can be useful tools for studying the roles of transition metals in their labile forms. Probes for imaging transition metal dynamics in living systems must meet several stringent criteria. In addition to exhibiting desirable photophysical properties and biocompatibility, they must be selective and show a fluorescence turn-on response to the metal of interest. To meet this challenge, we have pursued two general strategies for metal detection, termed “recognition” and “reactivity”. Our design of transition metal probes makes use of a recognition-based approach for copper and nickel and a reactivity-based approach for cobalt and iron. This Account summarizes progress in our laboratory on both the development and application of fluorescent probes to identify and study the signaling roles of transition metals in biology. In conjunction with complementary methods for direct metal detection and genetic and/or pharmacological manipulations, fluorescent probes for transition metals have helped reveal a number of principles underlying transition metal dynamics. In this Account, we give

  5. Design study of electron cyclotron resonance-ion plasma accelerator for heavy ion cancer therapy.

    PubMed

    Inoue, T; Hattori, T; Sugimoto, S; Sasai, K

    2014-02-01

    Electron Cyclotron Resonance-Ion Plasma Accelerator (ECR-IPAC) device, which theoretically can accelerate multiple charged ions to several hundred MeV with short acceleration length, has been proposed. The acceleration mechanism is based on the combination of two physical principles, plasma electron ion adiabatic ejection (PLEIADE) and Gyromagnetic Autoresonance (GYRAC). In this study, we have designed the proof of principle machine ECR-IPAC device and simulated the electromagnetic field distribution generating in the resonance cavity. ECR-IPAC device consisted of three parts, ECR ion source section, GYRAC section, and PLEIADE section. ECR ion source section and PLEIADE section were designed using several multi-turn solenoid coils and sextupole magnets, and GYRAC section was designed using 10 turns coil. The structure of ECR-IPAC device was the cylindrical shape, and the total length was 1024 mm and the maximum diameter was 580 mm. The magnetic field distribution, which maintains the stable acceleration of plasma, was generated on the acceleration center axis throughout three sections. In addition, the electric field for efficient acceleration of electrons was generated in the resonance cavity by supplying microwave of 2.45 GHz.

  6. Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    NASA Astrophysics Data System (ADS)

    Scisciò, M.; Lancia, L.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Papaphilippou, Y.; Antici, P.

    2016-03-01

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.

  7. Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scisciò, M.; Antici, P., E-mail: patrizio.antici@polytechnique.edu; INRS-EMT, Université du Québec, 1650 Lionel Boulet, Varennes, Québec J3X 1S2

    2016-03-07

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequencymore » (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.« less

  8. Results from the Wilkinson Microwave Anisotropy Probe

    NASA Technical Reports Server (NTRS)

    Komatsu, E.; Bennett, Charles L.; Komatsu, Eiichiro

    2015-01-01

    The Wilkinson Microwave Anisotropy Probe (WMAP) mapped the distribution of temperature and polarization over the entire sky in five microwave frequency bands. These full-sky maps were used to obtain measurements of temperature and polarization anisotropy of the cosmic microwave background with the unprecedented accuracy and precision. The analysis of two-point correlation functions of temperature and polarization data gives determinations of the fundamental cosmological parameters such as the age and composition of the universe, as well as the key parameters describing the physics of inflation, which is further constrained by three-point correlation functions. WMAP observations alone reduced the flat ? cold dark matter (Lambda Cold Dark Matter) cosmological model (six) parameter volume by a factor of > 68, 000 compared with pre-WMAP measurements. The WMAP observations (sometimes in combination with other astrophysical probes) convincingly show the existence of non-baryonic dark matter, the cosmic neutrino background, flatness of spatial geometry of the universe, a deviation from a scale-invariant spectrum of initial scalar fluctuations, and that the current universe is undergoing an accelerated expansion. The WMAP observations provide the strongest ever support for inflation; namely, the structures we see in the universe originate from quantum fluctuations generated during inflation.

  9. Plasma Wakefield Acceleration and FACET - Facilities for Accelerator Science and Experimental Test Beams at SLAC

    ScienceCinema

    Seryi, Andrei

    2017-12-22

    Plasma wakefield acceleration is one of the most promising approaches to advancing accelerator technology. This approach offers a potential 1,000-fold or more increase in acceleration over a given distance, compared to existing accelerators.  FACET, enabled by the Recovery Act funds, will study plasma acceleration, using short, intense pulses of electrons and positrons. In this lecture, the physics of plasma acceleration and features of FACET will be presented.  

  10. Probing the heliomagnetosphere

    NASA Technical Reports Server (NTRS)

    Venkatesan, D.; Krimigis, S. M.

    1990-01-01

    The results of recent studies of the heliomagnetosphere are reviewed. Emphasis is given to the visualization of the heliosphere by studying cosmic rays and plans to study the heliosphere in 3D using the Interstellar Probe.

  11. Acceleration of a ground-state reaction by selective femtosecond-infrared-laser-pulse excitation

    NASA Astrophysics Data System (ADS)

    Stensitzki, Till; Yang, Yang; Kozich, Valeri; Ahmed, Ashour A.; Kössl, Florian; Kühn, Oliver; Heyne, Karsten

    2018-02-01

    Infrared (IR) excitation of vibrations that participate in the reaction coordinate of an otherwise thermally driven chemical reaction are believed to lead to its acceleration. Attempts at the practical realization of this concept have been hampered so far by competing processes leading to sample heating. Here we demonstrate, using femtosecond IR-pump IR-probe experiments, the acceleration of urethane and polyurethane formation due to vibrational excitation of the reactants for 1:1 mixtures of phenylisocyanate and cyclohexanol, and toluene-2,4-diisocyanate and 2,2,2-trichloroethane-1,1-diol, respectively. We measured reaction rate changes upon selective vibrational excitation with negligible heating of the sample and observed an increase of the reaction rate up to 24%. The observation is rationalized using reactant and transition-state structures obtained from quantum chemical calculations. We subsequently used IR-driven reaction acceleration to write a polyurethane square on sample windows using a femtosecond IR pulse.

  12. FAST/Polar Conjunction Study of Field-Aligned Auroral Acceleration and Corresponding Magnetotail Drivers

    NASA Technical Reports Server (NTRS)

    Schriver, D.; Ashour-Abdalla, M.; Strangeway, R. J.; Richard, R. L.; Klezting, C.; Dotan, Y.; Wygant, J.

    2003-01-01

    The discrete aurora results when energized electrons bombard the Earth's atmosphere at high latitudes. This paper examines the physical processes that can cause field-aligned acceleration of plasma particles in the auroral region. A data and theoretical study has been carried out to examine the acceleration mechanisms that operate in the auroral zone and to identi@ the magnetospheric drivers of these acceleration mechanisms. The observations used in the study were collected by the Fast Auroral Snapshot (FAST) and Polar satellites when the two satellites were in approximate magnetic conjunction in the auroral region. During these events FAST was in the middle of the auroral zone and Polar was above the auroral zone in the near-Earth plasma sheet. Polar data were used to determine the conditions in the magnetotail at the time field-aligned acceleration was measured by FAST in the auroral zone. For each of the magnetotail drivers identified in the data study, the physics of field-aligned acceleration in the auroral region was examined using existing theoretical efforts and/or a long-system particle in cell simulation to model the magnetically connected region between the two satellites. Results from the study indicate that there are three main drivers of auroral acceleration: (1) field-aligned currents that lead to quasistatic parallel potential drops (parallel electric fields), (2) earthward flow of high-energy plasma beams from the magnetotail into the auroral zone that lead to quasistatic parallel potential drops, and (3) large-amplitude Alfven waves that propagate into the auroral region from the magnetotail. The events examined thus far confm the previously established invariant latitudinal dependence of the drivers and show a strong dependence on magnetic activity. Alfven waves tend to occur primarily at the poleward edge of the auroral region during more magnetically active times and are correlated with intense electron precipitation. At lower latitudes away

  13. Electrical resistivity probes

    DOEpatents

    Lee, Ki Ha; Becker, Alex; Faybishenko, Boris A.; Solbau, Ray D.

    2003-10-21

    A miniaturized electrical resistivity (ER) probe based on a known current-voltage (I-V) electrode structure, the Wenner array, is designed for local (point) measurement. A pair of voltage measuring electrodes are positioned between a pair of current carrying electrodes. The electrodes are typically about 1 cm long, separated by 1 cm, so the probe is only about 1 inch long. The electrodes are mounted to a rigid tube with electrical wires in the tube and a sand bag may be placed around the electrodes to protect the electrodes. The probes can be positioned in a borehole or on the surface. The electrodes make contact with the surrounding medium. In a dual mode system, individual probes of a plurality of spaced probes can be used to measure local resistance, i.e. point measurements, but the system can select different probes to make interval measurements between probes and between boreholes.

  14. Coupler Studies for PBG Fiber Accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    England, J.; Ng, C.; Noble, R.

    Photonic band gap (PBG) fiber with hollow core defects are being designed and fabricated for use as laser driven accelerators because they can provide gradients of several GeV/m for picosecond pulse lengths. We expect to produce fiber down to {lambda} = 1.5-2.0 {micro}m wavelengths but still lack a viable means for efficient coupling of laser power into such structures due to the very different character of the TM-like modes from those used in the telecom field and the fact that the defect must function as both a longitudinal waveguide for the accelerating field and a transport channel for the particles.more » We discuss the status of our work in pursuing both end and side coupling. For both options, the symmetry of these crystals leads to significant differences with the telecom field. Side coupling provides more options and appears to be preferred. Our goals are to test gradients, mode content and coupling efficiencies on the NLCTA at SLAC. While there are many potential types of fiber based on very different fabrication methods and materials we will concentrate on 2D axisymmetric glass with hexagonal symmetry but will discuss several different geometries including 2D and 3D planar structures. Since all of these can be fabricated using modern techniques with a variety of dielectric materials they are expected to have desirable optical and radiation hardness properties. Thus, we expect a new generation of very high gradient accelerators that extends the Livingston-Panofsky chart of exponential growth in energy vs. time at greatly reduced costs. For illustration, Fig.1 shows a simulation of our first engineered fiber with an accelerating mode expected near 7.3 {micro}m that is now ready to test on the NLCTA. In this example, one sees the uniform longitudinal accelerating field in the central defect as first shown by Lin3 together with a hexagonal array of surrounding hot spots. Contrary to what one expects from the telecom field, Ng et al. have shown4 that the

  15. Corrosion study of AA2024-T3 by scanning Kelvin probe force microscopy and in situ atomic force microscopy scratching

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schmutz, P.; Frankel, G.S.

    1998-07-01

    The localized corrosion of AA2024-T3, and the behavior of intermetallic particles in particular, were studied using different capabilities of the atomic force microscope (AFM). The role of intermetallic particles in determining the locations and rates of localized corrosion was determined using scanning Kelvin probe force microscopy in air after exposure to chloride solutions. Al-Cu-Mg particles, which have a noble Volta potential in air because of an altered surface film, are actively dissolved in chloride solution after a certain induction time. Al-Cu(Fe, Mn) particles are heterogeneous in nature and exhibit nonuniform dissolution in chloride solution as well as trenching of themore » matrix around the particles. Light scratching of the surface by rastering with the AFM tip in contact mode in chloride solution results in accelerated dissolution of both pure Al and alloy 2024-T3. The abrasion associated with contact AFM in situ resulted in the immediate dissolution of the Al-Cu-Mg particles because of a destabilization of the surface film.« less

  16. The World of Wonder Accelerated Learning Community: A Case Study.

    ERIC Educational Resources Information Center

    Biddle, Julie K.

    This report presents a case study of the World of Wonders Accelerated Learning Community School (WOW). A community school in Ohio is a new kind of public school-an independent public school that is nonsectarian and nondiscriminatory. The report presents three contexts for the study--historical, local and methodological--and highlights some of the…

  17. Mathematical study of probe arrangement and nanoparticle injection effects on heat transfer during cryosurgery.

    PubMed

    Mirkhalili, Seyyed Mostafa; Ramazani S A, Ahmad; Nazemidashtarjandi, Saeed

    2015-11-01

    Blood vessels, especially large vessels have a greater thermal effect on freezing tissue during cryosurgery. Vascular networks act as heat sources in tissue, and cause failure in cryosurgery and reappearance of cancer. The aim of this study is to numerically simulate the effect of probe location and multiprobe on heat transfer distribution. Furthermore, the effect of nanoparticles injection is studied. It is shown that the small probes location near large blood vessels could help to reduce the necessary time for tissue freezing. Nanoparticles injection shows that the thermal effect of blood vessel in tissue is improved. Using Au, Ag and diamond nanoparticles have the most growth of ice ball during cryosurgery. However, polytetrafluoroethylene (PTFE) nanoparticle can be used to protect normal tissue around tumor cell due to its influence on reducing heat transfer in tissue. Introduction of Au, Ag and diamond nanoparticles combined with multicryoprobe in this model causes reduction of tissue average temperature about 50% compared to the one probe. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Modified Betatron Accelerator Studies.

    DTIC Science & Technology

    1983-12-01

    extraction ports. 29 14 Combined negative mass and beam breakup instability growth rates (solid curves) for t - 13 and Be - 2 kG. Growth of the negative...a stable beam equilibrium 0 for the duration of the acceleration period, typically thousands of revolu- tions; and (c) extraction of the beam, which...bom extraction , it was felt that it would be premature to start work eI I’l 1r a S - - Fip’S .1IU~V~~’ f mdifedbetO coflCPt’ The ajo radius of U tS W

  19. Plasma Potential and Langmuir Probe Measurements in the Near-field Plume of the NASA-457Mv2 Hall Thruster

    NASA Technical Reports Server (NTRS)

    Shastry, Rohit; Huang, Wensheng; Herman, Daniel A.; Soulas, George C.; Kamhawi, Hani

    2012-01-01

    In order to further the design of future high-power Hall thrusters and provide experimental validation for ongoing modeling efforts, plasma potential and Langmuir probe measurements were performed on the 50-kW NASA-457Mv2. An electrostatic probe array comprised of a near-field Faraday probe, single Langmuir probe, and emissive probe was used to interrogate the near-field plume from approximately 0.1 - 2.0 mean thruster diameters downstream of the thruster exit plane at the following operating conditions: 300 V, 400 V and 500 V at 30 kW and 500 V at 50 kW. Results have shown that the acceleration zone is limited to within 0.4 mean thruster diameters of the exit plane while the high-temperature region is limited to 0.25 mean thruster diameters from the exit plane at all four operating conditions. Maximum plasma potentials in the near-field at 300 and 400 V were approximately 50 V with respect to cathode potential, while maximum electron temperatures varied from 24 - 32 eV, depending on operating condition. Isothermal lines at all operating conditions were found to strongly resemble the magnetic field topology in the high-temperature regions. This distribution was found to create regions of high temperature and low density near the magnetic poles, indicating strong, thick sheath formation along these surfaces. The data taken from this study are considered valuable for future design as well as modeling validation.

  20. Overview of Key Saturn Probe Mission Trades

    NASA Technical Reports Server (NTRS)

    Balint, Tibor S.; Kowalkowski, Theresa; Folkner, Bill

    2007-01-01

    Ongoing studies, performed at NASA/JPL over the past two years in support of NASA's SSE Roadmap activities, proved the feasibility of a NF class Saturn probe mission. I. This proposed mission could also provide a good opportunity for international collaboration with the proposed Cosmic Vision KRONOS mission: a) With ESA contributed probes (descent modules) on a NASA lead mission; b) Early 2017 launch could be a good programmatic option for ESA-CV/NASA-NF. II. A number of mission architectures could be suitable for this mission: a) Probe Relay based architecture with short flight time (approx. 6.3-7 years); b) DTE probe telecom based architecture with long flight time (-11 years), and low probe data rate, but with the probes decoupled from the carrier, allowing for polar trajectories I orbiter. This option may need technology development for telecom; c) Orbiter would likely impact mission cost over flyby, but would provide significantly higher science return. The Saturn probes mission is expected to be identified in NASA's New Frontiers AO. Thus, further studies are recommended to refine the most suitable architecture. International collaboration is started through the KRONOS proposal work; further collaborated studies will follow once KRONOS is selected in October under ESA's Cosmic Vision Program.

  1. Ultrafast scanning probe microscopy

    DOEpatents

    Weiss, Shimon; Chemla, Daniel S.; Ogletree, D. Frank; Botkin, David

    1995-01-01

    An ultrafast scanning probe microscopy method for achieving subpicosecond-temporal resolution and submicron-spatial resolution of an observation sample. In one embodiment of the present claimed invention, a single short optical pulse is generated and is split into first and second pulses. One of the pulses is delayed using variable time delay means. The first pulse is then directed at an observation sample located proximate to the probe of a scanning probe microscope. The scanning probe microscope produces probe-sample signals indicative of the response of the probe to characteristics of the sample. The second pulse is used to modulate the probe of the scanning probe microscope. The time delay between the first and second pulses is then varied. The probe-sample response signal is recorded at each of the various time delays created between the first and second pulses. The probe-sample response signal is then plotted as a function of time delay to produce a cross-correlation of the probe sample response. In so doing, the present invention provides simultaneous subpicosecond-temporal resolution and submicron-spatial resolution of the sample.

  2. Study on electrostatic and electromagnetic probes operated in ceramic and metallic depositing plasmas

    NASA Astrophysics Data System (ADS)

    Styrnoll, T.; Bienholz, S.; Lapke, M.; Awakowicz, P.

    2014-04-01

    This paper discusses plasma probe diagnostics, namely the multipole resonance probe (MRP) and Langmuir probe (LP), operated in depositing plasmas. The aim of this work is to show that the combination of both probes provides stable and robust measurements and clear determination of plasma parameters for metallic and ceramic coating processes. The probes use different approaches to determine plasma parameters, e.g. electron density ne and electron temperature Te. The LP is a well-established plasma diagnostic, and its applicability in technological plasmas is well documented. The LP is a dc probe that performs a voltage sweep and analyses the measured current, which makes it insensitive against conductive metallic coating. However, once the LP is dielectrically coated with a ceramic film, its functionality is constricted. In contrast, the MRP was recently presented as a monitoring tool, which is insensitive to coating with dielectric ceramics. It is a new plasma diagnostic based on the concept of active plasma resonance spectroscopy, which uses the universal characteristic of all plasmas to resonate on or near the electron plasma frequency. The MRP emits a frequency sweep and the absorption of the signal, the |S11| parameter, is analysed. Since the MRP concept is based on electromagnetic waves, which are able to transmit dielectrics, it is insensitive to dielectric coatings. But once the MRP is metallized with a thin conductive film, no undisturbed RF-signal can be emitted into the plasma, which leads to falsified plasma parameter. In order to compare both systems, during metallic or dielectric coating, the probes are operated in a magnetron CCP, which is equipped with a titanium target. We present measurements in metallic and dielectric coating processes with both probes and elaborate advantages and problems of each probe operated in each coating environment.

  3. Femtosecond Pump-Push-Probe and Pump-Dump-Probe Spectroscopy of Conjugated Polymers: New Insight and Opportunities.

    PubMed

    Kee, Tak W

    2014-09-18

    Conjugated polymers are an important class of soft materials that exhibit a wide range of applications. The excited states of conjugated polymers, often referred to as excitons, can either deactivate to yield the ground state or dissociate in the presence of an electron acceptor to form charge carriers. These interesting properties give rise to their luminescence and the photovoltaic effect. Femtosecond spectroscopy is a crucial tool for studying conjugated polymers. Recently, more elaborate experimental configurations utilizing three optical pulses, namely, pump-push-probe and pump-dump-probe, have been employed to investigate the properties of excitons and charge-transfer states of conjugated polymers. These studies have revealed new insight into femtosecond torsional relaxation and detrapping of bound charge pairs of conjugated polymers. This Perspective highlights (1) the recent achievements by several research groups in using pump-push-probe and pump-dump-probe spectroscopy to study conjugated polymers and (2) future opportunities and potential challenges of these techniques.

  4. Rotational Dynamics of Solutes with Multiple Single Bond Axes Studied by Infrared Pump-Probe Spectroscopy.

    PubMed

    Okuda, Masaki; Ohta, Kaoru; Tominaga, Keisuke

    2018-02-01

    To investigate the relationship between the structural degrees of freedom around a vibrational probe and the rotational relaxation process of a solute in solution, we studied the anisotropy decays of three different N 3 -derivatized amino acids in primary alcohol solutions. By performing polarization-controlled IR pump-probe measurements, we reveal that the anisotropy decays of the vibrational probe molecules in 1-alcohol solutions possess two decay components, at subpicosecond and picosecond time scales. On the basis of results showing that the fast relaxation component is insensitive to the vibrational probe molecule, we suggest that the anisotropy decay of the N 3 group on a subpicosecond time scale results from a local, small-amplitude fluctuation of the flexible vibrational probe, which does not depend on the details of its molecular structure. However, the slow relaxation component depends on the solute: with longer alkyl chains attached to the N 3 group, the anisotropy decay of the slow component is faster. Consequently, we conclude that the slow relaxation component corresponds to the reorientational motion of the N 3 group correlated with other intramolecular rotational motions (e.g., rotational motions of the neighboring alkyl chain). Our experimental results provide important insight into understanding the rotational dynamics of solutes with multiple single bond axes in solution.

  5. FRET study of G-quadruplex forming fluorescent oligonucleotide probes at the lipid monolayer interface.

    PubMed

    Swiatkowska, Angelika; Kosman, Joanna; Juskowiak, Bernard

    2016-01-05

    Spectral properties and G-quadruplex folding ability of fluorescent oligonucleotide probes at the cationic dioctadecyldimethylammonium bromide (DODAB) monolayer interface are reported. Two oligonucleotides, a 19-mer bearing thrombin binding aptamer sequence and a 21-mer with human telomeric sequence, were end-labeled with fluorescent groups (FAM and TAMRA) to give FRET probes F19T and F21T, respectively. The probes exhibited abilities to fold into a quadruplex structure and to bind metal cations (Na(+) and K(+)). Fluorescence spectra of G-quadruplex FRET probes at the monolayer interface are reported for the first time. Investigations included film balance measurements (π-A isotherms) and fluorescence spectra recording using a fiber optic accessory interfaced with a spectrofluorimeter. The effect of the presence of DODAB monolayer, metal cations and the surface pressure of monolayer on spectral behavior of FRET probes were examined. Adsorption of probe at the cationic monolayer interface resulted in the FRET signal enhancement even in the absence of metal cations. Variation in the monolayer surface pressure exerted rather modest effect on the spectral properties of probes. The fluorescence energy transfer efficiency of monolayer adsorbed probes increased significantly in the presence of sodium or potassium ion in subphase, which indicated that the probes retained their cation binding properties when adsorbed at the monolayer interface. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Feasibility study of low angle planetary entry. [probe design for Jovian entry

    NASA Technical Reports Server (NTRS)

    Defrees, R. E.

    1975-01-01

    The feasibility of a Jovian entry by a probe originally designed for Saturn and Uranus entries is examined. An entry probe is described which is capable of release near an outer planet's sphere of influence and descent to a predetermined target entry point in the planet's atmosphere. The probe is designed so as to survive the trapped particle radiation belts and an entry heating pulse. Data is gathered and relayed to an overflying spacecraft bus during descent. Probe variations for two similar missions are described. In the first flyby of Jupiter by a Pioneer spacecraft launched during the 1979 opportunity is examined parametrically. In the second mission an orbiter based on Pioneer and launched in 1980 is defined in specific terms. The differences rest in the science payloads and directly affected wiring and electronics packages.

  7. Uniformly accelerated black holes

    NASA Astrophysics Data System (ADS)

    Letelier, Patricio S.; Oliveira, Samuel R.

    2001-09-01

    The static and stationary C metric are examined in a generic framework and their interpretations studied in some detail, especially those with two event horizons, one for the black hole and another for the acceleration. We find that (i) the spacetime of an accelerated static black hole is plagued by either conical singularities or a lack of smoothness and compactness of the black hole horizon, (ii) by using standard black hole thermodynamics we show that accelerated black holes have a higher Hawking temperature than Unruh temperature of the accelerated frame, and (iii) the usual upper bound on the product of the mass and acceleration parameters (<1/27) is just a coordinate artifact. The main results are extended to accelerated rotating black holes with no significant changes.

  8. Experimental Study of Proton Acceleration from Ultra Intense Laser Matter Interactions

    NASA Astrophysics Data System (ADS)

    Paudel, Yadab Kumar

    This dissertation describes proton and ion acceleration measurements from high intensity (˜ 1019 Wcm-2) laser interactions with thin foil targets. Protons and ions accelerated from the back surface of a target driven by a high intensity laser are detected using solid-state nuclear track detector CR39. A simple digital imaging technique, with an adjustable halogen light source shined on CR39 and use of a digital camera with suitable f-number and exposure time, is used to detect particles tracks. This new technique improves the quality 2D image with vivid track patterns in CR39. Our technique allows us to quickly record and sort CR39 pieces for further analysis. This is followed by detailed quantitative information on the protons and ions. Protons and multicharged ions generated from high-intensity laser interactions with thin foil targets have been studied with a 100 TW laser system. Protons/ions with energies up to 10 MeV are accelerated either from the front or the rear surface of the target material. We have observed for the first time a self-radiograph of the target with a glass stalk holding the target itself in the stacked radiochromic films (RCF) placed behind the target. The self-radiography indicates that the fast ions accelerated backward, in a direction opposite to the laser propagation, are turning around in strong magnetic fields. This unique result is a signature of long-living (ns time scale) magnetic fields in the expanding plasma, which are important in energy transport during the intense laser irradiation and have never been considered in the previous studies. The magnetic fields induced by the main pulse near the absorption point expand rapidly with the backward accelerated protons in the pre-formed plasma. The protons are rotated by these magnetic fields and they are recorded in the RCF, making the self-radiography. Angular profiles of protons and multicharged ions accelerated from the target rear surface have been studied with the subpicosecond

  9. New atom probe approaches to studying segregation in nanocrystalline materials.

    PubMed

    Samudrala, S K; Felfer, P J; Araullo-Peters, V J; Cao, Y; Liao, X Z; Cairney, J M

    2013-09-01

    Atom probe is a technique that is highly suited to the study of nanocrystalline materials. It can provide accurate atomic-scale information about the composition of grain boundaries in three dimensions. In this paper we have analysed the microstructure of a nanocrystalline super-duplex stainless steel prepared by high pressure torsion (HPT). Not all of the grain boundaries in this alloy display obvious segregation, making visualisation of the microstructure challenging. In addition, the grain boundaries present in the atom probe data acquired from this alloy have complex shapes that are curved at the scale of the dataset and the interfacial excess varies considerably over the boundaries, making the accurate characterisation of the distribution of solute challenging using existing analysis techniques. In this paper we present two new data treatment methods that allow the visualisation of boundaries with little or no segregation, the delineation of boundaries for further analysis and the quantitative analysis of Gibbsian interfacial excess at boundaries, including the capability of excess mapping. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Discovering the Meaning of Unity of Purpose: A Case Study of Fourteen Accelerated Schools.

    ERIC Educational Resources Information Center

    Davidson, Betty M.; Dell, Geralyn L.

    This paper presents findings of a study that examined how teachers restructuring schools came to understand the meaning of the term "unity of purpose." Fourteen Louisiana schools, comprised primarily of high-risk student populations, implemented the accelerated-schools model of restructuring. The accelerated school model is based on…

  11. Fluorescence-based assay probing regulator of G protein signaling partner proteins.

    PubMed

    Huang, Po-Shiun; Yeh, Hsin-Sung; Yi, Hsiu-Ping; Lin, Chain-Jia; Yang, Chii-Shen

    2012-04-01

    The regulator of G protein signaling (RGS) proteins are one of the essential modulators for the G protein system. Besides regulating G protein signaling by accelerating the GTPase activity of Gα subunits, RGS proteins are implicated in exerting other functions; they are also known to be involved in several diseases. Moreover, the existence of a single RGS protein in plants and its seven-transmembrane domain found in 2003 triggered efforts to unveil detailed structural and functional information of RGS proteins. We present a method for real-time examination of the protein-protein interactions between RGS and Gα subunits. AtRGS1 from plants and RGS4 from mammals were site-directedly labeled with the fluorescent probe Lucifer yellow on engineered cysteine residues and used to interact with different Gα subunits. The physical interactions can be revealed by monitoring the real-time fluorescence changes (8.6% fluorescence increase in mammals and 27.6% in plants); their correlations to functional exertion were shown with a GTPase accelerating activity assay and further confirmed by measurement of K(d). We validate the effectiveness of this method and suggest its application to the exploration of more RGS signaling partner proteins in physiological and pathological studies. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Proposal for an Accelerator R&D User Facility at Fermilab's Advanced Superconducting Test Accelerator (ASTA)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Church, M.; Edwards, H.; Harms, E.

    2013-10-01

    Fermilab is the nation’s particle physics laboratory, supported by the DOE Office of High Energy Physics (OHEP). Fermilab is a world leader in accelerators, with a demonstrated track-record— spanning four decades—of excellence in accelerator science and technology. We describe the significant opportunity to complete, in a highly leveraged manner, a unique accelerator research facility that supports the broad strategic goals in accelerator science and technology within the OHEP. While the US accelerator-based HEP program is oriented toward the Intensity Frontier, which requires modern superconducting linear accelerators and advanced highintensity storage rings, there are no accelerator test facilities that support themore » accelerator science of the Intensity Frontier. Further, nearly all proposed future accelerators for Discovery Science will rely on superconducting radiofrequency (SRF) acceleration, yet there are no dedicated test facilities to study SRF capabilities for beam acceleration and manipulation in prototypic conditions. Finally, there are a wide range of experiments and research programs beyond particle physics that require the unique beam parameters that will only be available at Fermilab’s Advanced Superconducting Test Accelerator (ASTA). To address these needs we submit this proposal for an Accelerator R&D User Facility at ASTA. The ASTA program is based on the capability provided by an SRF linac (which provides electron beams from 50 MeV to nearly 1 GeV) and a small storage ring (with the ability to store either electrons or protons) to enable a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop transformative approaches to particle-beam generation, acceleration and manipulation which cannot be done elsewhere. It will also establish a unique resource for R&D towards Energy Frontier facilities and a test-bed for SRF accelerators and high brightness beam applications in support of the

  13. Computational study of radiation doses at UNLV accelerator facility

    NASA Astrophysics Data System (ADS)

    Hodges, Matthew; Barzilov, Alexander; Chen, Yi-Tung; Lowe, Daniel

    2017-09-01

    A Varian K15 electron linear accelerator (linac) has been considered for installation at University of Nevada, Las Vegas (UNLV). Before experiments can be performed, it is necessary to evaluate the photon and neutron spectra as generated by the linac, as well as the resulting dose rates within the accelerator facility. A computational study using MCNPX was performed to characterize the source terms for the bremsstrahlung converter. The 15 MeV electron beam available in the linac is above the photoneutron threshold energy for several materials in the linac assembly, and as a result, neutrons must be accounted for. The angular and energy distributions for bremsstrahlung flux generated by the interaction of the 15 MeV electron beam with the linac target were determined. This source term was used in conjunction with the K15 collimators to determine the dose rates within the facility.

  14. Ultrafast scanning probe microscopy

    DOEpatents

    Weiss, S.; Chemla, D.S.; Ogletree, D.F.; Botkin, D.

    1995-05-16

    An ultrafast scanning probe microscopy method is described for achieving subpicosecond-temporal resolution and submicron-spatial resolution of an observation sample. In one embodiment of the present claimed invention, a single short optical pulse is generated and is split into first and second pulses. One of the pulses is delayed using variable time delay means. The first pulse is then directed at an observation sample located proximate to the probe of a scanning probe microscope. The scanning probe microscope produces probe-sample signals indicative of the response of the probe to characteristics of the sample. The second pulse is used to modulate the probe of the scanning probe microscope. The time delay between the first and second pulses is then varied. The probe-sample response signal is recorded at each of the various time delays created between the first and second pulses. The probe-sample response signal is then plotted as a function of time delay to produce a cross-correlation of the probe sample response. In so doing, the present invention provides simultaneous subpicosecond-temporal resolution and submicron-spatial resolution of the sample. 6 Figs.

  15. Trunk acceleration for neuroprosthetic control of standing: a pilot study.

    PubMed

    Nataraj, Raviraj; Audu, Musa L; Kirsch, Robert F; Triolo, Ronald J

    2012-02-01

    This pilot study investigated the potential of using trunk acceleration feedback control of center of pressure (COP) against postural disturbances with a standing neuroprosthesis following paralysis. Artificial neural networks (ANNs) were trained to use three-dimensional trunk acceleration as input to predict changes in COP for able-bodied subjects undergoing perturbations during bipedal stance. Correlation coefficients between ANN predictions and actual COP ranged from 0.67 to 0.77. An ANN trained across all subject-normalized data was used to drive feedback control of ankle muscle excitation levels for a computer model representing a standing neuroprosthesis user. Feedback control reduced average upper-body loading during perturbation onset and recovery by 42% and peak loading by 29% compared with optimal, constant excitation.

  16. Alveolar Bone Morphology Following Periodontally Accelerated Osteogenic Orthodontics: A Clinical and Radiographic Analysis.

    PubMed

    Chackartchi, Tali; Barkana, Idit; Klinger, Avigdor

    The aim of this study was to analyze alveolar bone morphology following periodontally accelerated osteogenic orthodontics. Treated patients were called for a full periodontal examination and a cone beam computed tomography scan. Mean treatment time was 6.08 months. Mean probing pocket depth was 2.7 mm. No gingival recessions were noted. In the maxilla, buccal plate thickness was 0.48 to 2.14 mm. In the mandible, bone thickness was 0.2 to 1.82 mm. Root fenestrations and dehiscences were present in up to 40% of the anterior teeth. Although clinical outcomes were favorable, due to the presence of multiple posttreatment bone fenestrations and dehiscences, a revision of the treatment protocol might be considered.

  17. Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study

    PubMed Central

    Hsu, Hung-Yao

    2016-01-01

    Bone cells are deformed according to mechanical stimulation they receive and their mechanical characteristics. However, how osteoblasts are affected by mechanical vibration frequency and acceleration amplitude remains unclear. By developing 3D osteoblast finite element (FE) models, this study investigated the effect of cell shapes on vibration characteristics and effect of acceleration (vibration intensity) on vibrational responses of cultured osteoblasts. Firstly, the developed FE models predicted natural frequencies of osteoblasts within 6.85–48.69 Hz. Then, three different levels of acceleration of base excitation were selected (0.5, 1, and 2 g) to simulate vibrational responses, and acceleration of base excitation was found to have no influence on natural frequencies of osteoblasts. However, vibration response values of displacement, stress, and strain increased with the increase of acceleration. Finally, stress and stress distributions of osteoblast models under 0.5 g acceleration in Z-direction were investigated further. It was revealed that resonance frequencies can be a monotonic function of cell height or bottom area when cell volumes and material properties were assumed as constants. These findings will be useful in understanding how forces are transferred and influence osteoblast mechanical responses during vibrations and in providing guidance for cell culture and external vibration loading in experimental and clinical osteogenesis studies. PMID:28074178

  18. Do In Situ Observations Contain Signatures of Intermittent Fast Solar Wind Acceleration?

    NASA Astrophysics Data System (ADS)

    Matteini, L.; Horbury, T. S.; Stansby, D.

    2017-12-01

    Disentangling local plasma properties and Solar origin structures in in situ data is a crucial aspect for the understanding of solar wind acceleration and evolution. This is particularly challenging at 1 AU and beyond, where structures of various origin have had time to interact and merge, smoothing out their main characteristics. Observations of more pristine plasma closer to the Sun are therefore needed. In preparation of the forthcoming Solar Orbiter and Parker Solar Probe missions, Helios observations as close as to 0.3 AU - although old, not yet fully exploited - can be used to test our expectations and make new predictions. Recent observations (Matteini et al. 2014, 2015) have outlined the presence of intense (up to 1000km/s) and short-living velocity peaks that ubiquitously characterize the typical profile of the fast solar wind at 0.3 AU, suggesting that these features could be remnants of processes occurring in the Solar atmosphere and a signature of intermittent solar wind acceleration from coronal holes. We discuss results about statistics of these events, characterizing their physical properties and trying to link them with typical Solar temporal and spatial scales. Finally we also discuss how these velocity peaks will likely affect the future in situ exploration of the inner heliosphere by Solar Orbiter and the Parker Solar Probe.

  19. Fluorescence studies with DNA probes: dynamic aspects of DNA structure and DNA-protein interactions

    NASA Astrophysics Data System (ADS)

    Millar, David P.; Carver, Theodore E.

    1994-08-01

    Time-resolved fluorescence measurements of optical probes incorporated at specific sites in DNA provides a new approach to studies of DNA structure and DNA:protein interactions. This approach can be used to study complex multi-state behavior, such as the folding of DNA into alternative higher order structures or the transfer of DNA between multiple binding sites on a protein. In this study, fluorescence anisotropy decay of an internal dansyl probe attached to 17/27-mer oligonucleotides was used to monitor the distribution of DNA 3' termini bound at either the polymerase of 3' to 5' exonuclease sites of the Klenow fragment of DNA polymerase I. Partitioning of the primer terminus between the two active sites of the enzyme resulted in a heterogeneous probe environment, reflected in the associative behavior of the fluorescence anisotropy decay. Analysis of the anisotropy decay with a two state model of solvent-exposed and protein-associated dansyl probes was used to determine the fraction of DNA bound at each site. We examined complexes of Klenow fragment with DNAs containing various base mismatches. Single mismatches at the primer terminus caused a 3-fold increase in the equilibrium partitioning of DNA into the exonuclease site, while two or more consecutive G:G mismatches caused the DNA to bind exclusively at the exonuclease site, with a partitioning constant at least 250- fold greater than that of the corresponding matched DNA sequence. Internal single mismatches located up to four bases from the primer terminus produced larger effects than the same mismatch at the primer terminus. These results provide insight into the recognition mechanisms that enable DNA polymerases to proofread misincorporated bases during DNA replication.

  20. A versatile rotary-stage high frequency probe station for studying magnetic films and devices

    NASA Astrophysics Data System (ADS)

    He, Shikun; Meng, Zhaoliang; Huang, Lisen; Yap, Lee Koon; Zhou, Tiejun; Panagopoulos, Christos

    2016-07-01

    We present a rotary-stage microwave probe station suitable for magnetic films and spintronic devices. Two stages, one for field rotation from parallel to perpendicular to the sample plane (out-of-plane) and the other intended for field rotation within the sample plane (in-plane) have been designed. The sample probes and micro-positioners are rotated simultaneously with the stages, which allows the field orientation to cover θ from 0∘ to 90∘ and φ from 0∘ to 360∘. θ and φ being the angle between the direction of current flow and field in a out-of-plane and an in-plane rotation, respectively. The operation frequency is up to 40 GHz and the magnetic field up to 1 T. The sample holder vision system and probe assembly are compactly designed for the probes to land on a wafer with diameter up to 3 cm. Using homemade multi-pin probes and commercially available high frequency probes, several applications including 4-probe DC measurements, the determination of domain wall velocity, and spin transfer torque ferromagnetic resonance are demonstrated.

  1. High temperature probe

    DOEpatents

    Swan, Raymond A.

    1994-01-01

    A high temperature probe for sampling, for example, smokestack fumes, and is able to withstand temperatures of 3000.degree. F. The probe is constructed so as to prevent leakage via the seal by placing the seal inside the water jacket whereby the seal is not exposed to high temperature, which destroys the seal. The sample inlet of the probe is also provided with cooling fins about the area of the seal to provide additional cooling to prevent the seal from being destroyed. Also, a heated jacket is provided for maintaining the temperature of the gas being tested as it passes through the probe. The probe includes pressure sensing means for determining the flow velocity of an efficient being sampled. In addition, thermocouples are located in various places on the probe to monitor the temperature of the gas passing there through.

  2. Study on a New Ultraviolet Sterilizer to the Surface Disinfection of the Ultrasound Probe.

    PubMed

    Chen, Gui Qiu; Chen, Yu Hao; Yi, Liang; Yin, Jin; Gao, Qiong; Song, Jiang Nan; Li, Shi Kang; Chen, Pei Hou; Guo, Gui Ping

    2018-02-01

    We studied the disinfection effect of a new ultraviolet (UV) sterilizer and its utilization on ultrasound probe surfaces. Carrier quantitative germicidal tests, simulated on-the-spot trials, and organic substance influence tests were used to carry out experimental observation. Artificially infected probes were disinfected using the sterilizer or a germicidal lamp for comparison. The total number and types of bacteria were determined and identified. Our results demonstrated the sterilizer had the best disinfection effect among three different disinfection methods in hospital. The sterilizer has been used in a hospital setting for 2 years with no notable damage to the ultrasound probe instrument. It has the advantages of fast disinfection, high disinfection effect, and good compatibility with the ultrasound instrument, worthy of being a promoted application in medical institutions. Copyright © 2018 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  3. Modification of 1,2,4,5-tetrazine with cationic rhenium(I) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics.

    PubMed

    Choi, Alex Wing-Tat; Tso, Karson Ka-Shun; Yim, Vicki Man-Wai; Liu, Hua-Wei; Lo, Kenneth Kam-Wing

    2015-02-25

    New phosphorogenic bioorthogonal probes derived from mononuclear and binuclear rhenium(I) polypyridine complexes containing a 1,2,4,5-tetrazine moiety were designed; these complexes displayed substantial dienophile-induced emission enhancement, and accelerated reaction kinetics and could target a protein conjugate in living cells.

  4. STUDIES OF A FREE ELECTRON LASER DRIVEN BY A LASER-PLASMA ACCELERATOR

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Montgomery, A.; Schroeder, C.; Fawley, W.

    A free electron laser (FEL) uses an undulator, a set of alternating magnets producing a periodic magnetic fi eld, to stimulate emission of coherent radiation from a relativistic electron beam. The Lasers, Optical Accelerator Systems Integrated Studies (LOASIS) group at Lawrence Berkeley National Laboratory (LBNL) will use an innovative laserplasma wakefi eld accelerator to produce an electron beam to drive a proposed FEL. In order to optimize the FEL performance, the dependence on electron beam and undulator parameters must be understood. Numerical modeling of the FEL using the simulation code GINGER predicts the experimental results for given input parameters. Amongmore » the parameters studied were electron beam energy spread, emittance, and mismatch with the undulator focusing. Vacuum-chamber wakefi elds were also simulated to study their effect on FEL performance. Energy spread was found to be the most infl uential factor, with output FEL radiation power sharply decreasing for relative energy spreads greater than 0.33%. Vacuum chamber wakefi elds and beam mismatch had little effect on the simulated LOASIS FEL at the currents considered. This study concludes that continued improvement of the laser-plasma wakefi eld accelerator electron beam will allow the LOASIS FEL to operate in an optimal regime, producing high-quality XUV and x-ray pulses.« less

  5. Systems-level study of a nonsurvivable Jupiter turbopause probe. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    Wiltshire, R. S.

    1972-01-01

    The design of a space probe to explore the atmosphere of the planet Jupiter is discussed. Five major areas were considered: (1) definition of science requirements, (2) mission evaluation, (3) definition of probe system, (4) definition of spacecraft support requirements, and (5) nonequilibrium flow field analysis for communications blackout evaluation. The overall mission and system design are emphasized. The integration of the various technologies into complete systems designs is described. Results showed that a nonsurvivable turbopause probe mission to Jupiter with adequate data return to meet the science objectives is feasible and practical.

  6. Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

    PubMed Central

    Nadler, André; Haberkant, Per; Kirkpatrick, Joanna; Schifferer, Martina; Stein, Frank; Hauke, Sebastian; Porter, Forbes D.; Schultz, Carsten

    2017-01-01

    Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid−protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo–cross-linking in a sequential manner, as well as a click-handle for subsequent functionalization. We demonstrate the versatility of the design for the signaling lipids sphingosine and diacylglycerol; uncaging of the probe for these two species triggered calcium signaling and intracellular protein translocation events, respectively. We performed proteomic screens to map the lipid-interacting proteome for both lipids. Finally, we visualized a sphingosine transport deficiency in patient-derived Niemann−Pick disease type C fibroblasts by fluorescence as well as correlative light and electron microscopy, pointing toward the diagnostic potential of such tools. We envision that this type of probe will become important for analyzing and ultimately understanding lipid signaling events in a comprehensive manner. PMID:28154130

  7. Probe tip heating assembly

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schmitz, Roger William; Oh, Yunje

    A heating assembly configured for use in mechanical testing at a scale of microns or less. The heating assembly includes a probe tip assembly configured for coupling with a transducer of the mechanical testing system. The probe tip assembly includes a probe tip heater system having a heating element, a probe tip coupled with the probe tip heater system, and a heater socket assembly. The heater socket assembly, in one example, includes a yoke and a heater interface that form a socket within the heater socket assembly. The probe tip heater system, coupled with the probe tip, is slidably receivedmore » and clamped within the socket.« less

  8. Atmospheric entry probes for outer planet exploration. Outer planet entry probe technical summary

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The use of unmanned space probes for investigating the conditions existing on and around the outer planets of the solar system is discussed. The subjects included in the report are: (1) the design of a common entry probe for outer planet missions, (2) the significant trades related to the development of a common probe design, (3) the impact of bus selection on probe design, (4) the impact of probe requirements on bus modifications, and (5) the key technology elements recommended for advanced development. Drawings and illustrations of typical probes are included to show the components and systems used in the space probes.

  9. Optical probe

    DOEpatents

    Hencken, Kenneth; Flower, William L.

    1999-01-01

    A compact optical probe is disclosed particularly useful for analysis of emissions in industrial environments. The instant invention provides a geometry for optically-based measurements that allows all optical components (source, detector, rely optics, etc.) to be located in proximity to one another. The geometry of the probe disclosed herein provides a means for making optical measurements in environments where it is difficult and/or expensive to gain access to the vicinity of a flow stream to be measured. Significantly, the lens geometry of the optical probe allows the analysis location within a flow stream being monitored to be moved while maintaining optical alignment of all components even when the optical probe is focused on a plurality of different analysis points within the flow stream.

  10. AXIS - A High Angular Resoltuion X-ray Probe Concept Study

    NASA Astrophysics Data System (ADS)

    Mushotzky, Richard; AXIS Study Team

    2018-01-01

    AXIS is a probe-class concept under study to the 2020 Decadal survey. AXIS will extend and enhance the science of high angular resolution x-ray imaging and spectroscopy in the next decade with ~0.3" angular resolution over a 7' radius field of view and an order of magnitude more collecting area than Chandra in the 0.3-12 keV band with a cost consistent with a probe.These capabilities enable major advances in a wide range of science such as: (1) measuring the event horizon scale structure in AGN accretion disks and the spins of supermassive black holes through observations of gravitationally-microlensed quasars; (ii) determining AGN and starburst feedback in galaxies and galaxy clusters through direct imaging of winds and interaction of jets and via spatially resolved imaging of galaxies at high-z; (iii) fueling of AGN by probing the Bondi radius of over 20 nearby galaxies; (iv) hierarchical structure formation and the SMBH merger rate through measurement of the occurrence rate of dual AGN and occupation fraction of SMBHs; (v) advancing SNR physics and galaxy ecology through large detailed samples of SNR in nearby galaxies; (vi) measuring the Cosmic Web through its connection to cluster outskirts. With a nominal 2028 launch, AXIS benefits from natural synergies with the ELTs, LSST, ALMA, WFIRST and ATHENA. AXIS utilizes breakthroughs in the construction of lightweight X-ray optics from mono-crystalline silicon blocks, and developments in the fabrication of large format, small pixel, high readout rate detectors allowing a robust and cost effective design. The AXIS team welcomes input and feedback from the community in preparation for the 2020 Decadal review.

  11. Pump-probe study of the formation of rubidium molecules by ultrafast photoassociation of ultracold atoms

    NASA Astrophysics Data System (ADS)

    McCabe, David J.; England, Duncan G.; Martay, Hugo E. L.; Friedman, Melissa E.; Petrovic, Jovana; Dimova, Emiliya; Chatel, Béatrice; Walmsley, Ian A.

    2009-09-01

    An experimental pump-probe study of the photoassociative creation of translationally ultracold rubidium molecules is presented together with numerical simulations of the process. The formation of loosely bound excited-state dimers is observed as a first step toward a fully coherent pump-dump approach to the stabilization of Rb2 into its lowest ground vibrational states. The population that contributes to the pump-probe process is characterized and found to be distinct from a background population of preassociated molecules.

  12. Studies of Ion Acceleration from Thin Solid-Density Targets on High-Intensity Lasers

    NASA Astrophysics Data System (ADS)

    Willis, Christopher R.

    Over the past two decades, a number of experiments have been performed demonstrating the acceleration of ions from the interaction of an intense laser pulse with a thin, solid density target. These ions are accelerated by quasi-static electric fields generated by energetic electrons produced at the front of the target, resulting in ion energies up to tens of MeV. These ions have been widely studied for a variety of potential applications ranging from treatment of cancer to the production of neutrons for advanced radiography techniques. However, realization of these applications will require further optimization of the maximum energy, spectrum, or species of the accelerated ions, which has been a primary focus of research to date. This thesis presents two experiments designed to optimize several characteristics of the accelerated ion beam. The first of these experiments took place on the GHOST laser system at the University of Texas at Austin, and was designed to demonstrate reliable acceleration of deuterium ions, as needed for the most efficient methods of neutron generation from accelerated ions. This experiment leveraged cryogenically cooled targets coated in D2 O ice to suppress the protons which typically dominate the accelerated ions, producing as many as 2 x 1010 deuterium ions per 1 J laser shot, exceeding the proton yield by an average ratio of 5:1. The second major experiment in this work was performed on the Scarlet laser system at The Ohio State University, and studied the accelerated ion energy, yield, and spatial distribution as a function of the target thickness. In principle, the peak energy increases with decreasing target thickness, with the thinnest targets accessing additional acceleration mechanisms which provide favorable scaling with the laser intensity. However, laser prepulse characteristics provide a lower bound for the target thickness, yielding an optimum target thickness for ion acceleration which is dependent on the laser system. This

  13. Motion sickness and otolith sensitivity - A pilot study of habituation to linear acceleration

    NASA Technical Reports Server (NTRS)

    Potvin, A. R.; Sadoff, M.; Billingham, J.

    1977-01-01

    Astronauts, particularly in Skylab flights, experienced varying degrees of motion sickness lasting 3-5 days. One possible mechanism for this motion sickness adaptation is believed to be a reduction in otolith sensitivity with an attendant reduction in sensory conflict. In an attempt to determine if this hypothesis is valid, a ground-based pilot study was conducted on a vertical linear accelerator. The extent of habituation to accelerations which initially produced motion sickness was evaluated, along with the possible value of habituation training to minimize the space motion sickness problem. Results showed that habituation occurred for 6 of the 8 subjects tested. However, in tests designed to measure dynamic and static otolith function, no significant differences between pre- and post-habituation tests were observed. Cross habituation effects to a standard Coriolis acceleration test were not significant. It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness.

  14. Preventing probe induced topography correlated artifacts in Kelvin Probe Force Microscopy.

    PubMed

    Polak, Leo; Wijngaarden, Rinke J

    2016-12-01

    Kelvin Probe Force Microscopy (KPFM) on samples with rough surface topography can be hindered by topography correlated artifacts. We show that, with the proper experimental configuration and using homogeneously metal coated probes, we are able to obtain amplitude modulation (AM) KPFM results on a gold coated sample with rough topography that are free from such artifacts. By inducing tip inhomogeneity through contact with the sample, clear potential variations appear in the KPFM image, which correlate with the surface topography and, thus, are probe induced artifacts. We find that switching to frequency modulation (FM) KPFM with such altered probes does not remove these artifacts. We also find that the induced tip inhomogeneity causes a lift height dependence of the KPFM measurement, which can therefore be used as a check for the presence of probe induced topography correlated artifacts. We attribute the observed effects to a work function difference between the tip and the rest of the probe and describe a model for such inhomogeneous probes that predicts lift height dependence and topography correlated artifacts for both AM and FM-KPFM methods. This work demonstrates that using a probe with a homogeneous work function and preventing tip changes is essential for KPFM on non-flat samples. From the three investigated probe coatings, PtIr, Au and TiN, the latter appears to be the most suitable, because of its better resistance against coating damage. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Fluorogenic PNA probes

    PubMed Central

    2018-01-01

    Fluorogenic oligonucleotide probes that can produce a change in fluorescence signal upon binding to specific biomolecular targets, including nucleic acids as well as non-nucleic acid targets, such as proteins and small molecules, have applications in various important areas. These include diagnostics, drug development and as tools for studying biomolecular interactions in situ and in real time. The probes usually consist of a labeled oligonucleotide strand as a recognition element together with a mechanism for signal transduction that can translate the binding event into a measurable signal. While a number of strategies have been developed for the signal transduction, relatively little attention has been paid to the recognition element. Peptide nucleic acids (PNA) are DNA mimics with several favorable properties making them a potential alternative to natural nucleic acids for the development of fluorogenic probes, including their very strong and specific recognition and excellent chemical and biological stabilities in addition to their ability to bind to structured nucleic acid targets. In addition, the uncharged backbone of PNA allows for other unique designs that cannot be performed with oligonucleotides or analogues with negatively-charged backbones. This review aims to introduce the principle, showcase state-of-the-art technologies and update recent developments in the areas of fluorogenic PNA probes during the past 20 years. PMID:29507634

  16. Laser Wakefield Acceleration: Structural and Dynamic Studies. Final Technical Report ER40954

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Downer, Michael C.

    2014-04-30

    Particle accelerators enable scientists to study the fundamental structure of the universe, but have become the largest and most expensive of scientific instruments. In this project, we advanced the science and technology of laser-plasma accelerators, which are thousands of times smaller and less expensive than their conventional counterparts. In a laser-plasma accelerator, a powerful laser pulse exerts light pressure on an ionized gas, or plasma, thereby driving an electron density wave, which resembles the wake behind a boat. Electrostatic fields within this plasma wake reach tens of billions of volts per meter, fields far stronger than ordinary non-plasma matter (suchmore » as the matter that a conventional accelerator is made of) can withstand. Under the right conditions, stray electrons from the surrounding plasma become trapped within these “wake-fields”, surf them, and acquire energy much faster than is possible in a conventional accelerator. Laser-plasma accelerators thus might herald a new generation of compact, low-cost accelerators for future particle physics, x-ray and medical research. In this project, we made two major advances in the science of laser-plasma accelerators. The first of these was to accelerate electrons beyond 1 gigaelectronvolt (1 GeV) for the first time. In experimental results reported in Nature Communications in 2013, about 1 billion electrons were captured from a tenuous plasma (about 1/100 of atmosphere density) and accelerated to 2 GeV within about one inch, while maintaining less than 5% energy spread, and spreading out less than ½ milliradian (i.e. ½ millimeter per meter of travel). Low energy spread and high beam collimation are important for applications of accelerators as coherent x-ray sources or particle colliders. This advance was made possible by exploiting unique properties of the Texas Petawatt Laser, a powerful laser at the University of Texas at Austin that produces pulses of 150 femtoseconds (1 femtosecond

  17. Optimisation of readout performance of phase-change probe memory in terms of capping layer and probe tip

    NASA Astrophysics Data System (ADS)

    Wang, Lei; Wright, C. David; Aziz, Mustafa. M.; Yang, Ci Hui; Yang, Guo Wei

    2014-11-01

    The capping layer and the probe tip that serve as the protective layer and the recording tool, respectively, for phase-change probe memory play an important role on the writing performance of phase-change probe memory, thus receiving considerable attention. On the other hand, their influence on the readout performance of phasechange probe memory has rarely been reported before. A three-dimensional parametric study based on the Laplace equation was therefore conducted to investigate the effect of the capping layer and the probe tip on the resulting reading contrast for the two cases of reading a crystalline bit from an amorphous matrix and reading an amorphous bit from a crystalline matrix. The results indicated that a capping layer with a thickness of 2 nm and an electrical conductivity of 50 Ω-1m-1 is able to provide an appropriate reading contrast for both the cases, while satisfying the previous writing requirement, particularly with the assistance of a platinum silicide probe tip.

  18. Mega-electron-volt ultrafast electron diffraction at SLAC National Accelerator Laboratory.

    PubMed

    Weathersby, S P; Brown, G; Centurion, M; Chase, T F; Coffee, R; Corbett, J; Eichner, J P; Frisch, J C; Fry, A R; Gühr, M; Hartmann, N; Hast, C; Hettel, R; Jobe, R K; Jongewaard, E N; Lewandowski, J R; Li, R K; Lindenberg, A M; Makasyuk, I; May, J E; McCormick, D; Nguyen, M N; Reid, A H; Shen, X; Sokolowski-Tinten, K; Vecchione, T; Vetter, S L; Wu, J; Yang, J; Dürr, H A; Wang, X J

    2015-07-01

    Ultrafast electron probes are powerful tools, complementary to x-ray free-electron lasers, used to study structural dynamics in material, chemical, and biological sciences. High brightness, relativistic electron beams with femtosecond pulse duration can resolve details of the dynamic processes on atomic time and length scales. SLAC National Accelerator Laboratory recently launched the Ultrafast Electron Diffraction (UED) and microscopy Initiative aiming at developing the next generation ultrafast electron scattering instruments. As the first stage of the Initiative, a mega-electron-volt (MeV) UED system has been constructed and commissioned to serve ultrafast science experiments and instrumentation development. The system operates at 120-Hz repetition rate with outstanding performance. In this paper, we report on the SLAC MeV UED system and its performance, including the reciprocal space resolution, temporal resolution, and machine stability.

  19. Ion beams provided by small accelerators for material synthesis and characterization

    NASA Astrophysics Data System (ADS)

    Mackova, Anna; Havranek, Vladimir

    2017-06-01

    The compact, multipurpose electrostatic tandem accelerators are extensively used for production of ion beams with energies in the range from 400 keV to 24 MeV of almost all elements of the periodic system for the trace element analysis by means of nuclear analytical methods. The ion beams produced by small accelerators have a broad application, mainly for material characterization (Rutherford Back-Scattering spectrometry, Particle Induced X ray Emission analysis, Nuclear Reaction Analysis and Ion-Microprobe with 1 μm lateral resolution among others) and for high-energy implantation. Material research belongs to traditionally progressive fields of technology. Due to the continuous miniaturization, the underlying structures are far beyond the analytical limits of the most conventional methods. Ion Beam Analysis (IBA) techniques provide this possibility as they use probes of similar or much smaller dimensions (particles, radiation). Ion beams can be used for the synthesis of new progressive functional nanomaterials for optics, electronics and other applications. Ion beams are extensively used in studies of the fundamental energetic ion interaction with matter as well as in the novel nanostructure synthesis using ion beam irradiation in various amorphous and crystalline materials in order to get structures with extraordinary functional properties. IBA methods serve for investigation of materials coming from material research, industry, micro- and nano-technology, electronics, optics and laser technology, chemical, biological and environmental investigation in general. Main research directions in laboratories employing small accelerators are also the preparation and characterization of micro- and nano-structured materials which are of interest for basic and oriented research in material science, and various studies of biological, geological, environmental and cultural heritage artefacts are provided too.

  20. Simulation Studies of the Dielectric Grating as an Accelerating and Focusing Structure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soong, Ken; Peralta, E.A.; Byer, R.L.

    A grating-based design is a promising candidate for a laser-driven dielectric accelerator. Through simulations, we show the merits of a readily fabricated grating structure as an accelerating component. Additionally, we show that with a small design perturbation, the accelerating component can be converted into a focusing structure. The understanding of these two components is critical in the successful development of any complete accelerator. The concept of accelerating electrons with the tremendous electric fields found in lasers has been proposed for decades. However, until recently the realization of such an accelerator was not technologically feasible. Recent advances in the semiconductor industry,more » as well as advances in laser technology, have now made laser-driven dielectric accelerators imminent. The grating-based accelerator is one proposed design for a dielectric laser-driven accelerator. This design, which was introduced by Plettner, consists of a pair of opposing transparent binary gratings, illustrated in Fig. 1. The teeth of the gratings serve as a phase mask, ensuring a phase synchronicity between the electromagnetic field and the moving particles. The current grating accelerator design has the drive laser incident perpendicular to the substrate, which poses a laser-structure alignment complication. The next iteration of grating structure fabrication seeks to monolithically create an array of grating structures by etching the grating's vacuum channel into a fused silica wafer. With this method it is possible to have the drive laser confined to the plane of the wafer, thus ensuring alignment of the laser-and-structure, the two grating halves, and subsequent accelerator components. There has been previous work using 2-dimensional finite difference time domain (2D-FDTD) calculations to evaluate the performance of the grating accelerator structure. However, this work approximates the grating as an infinite structure and does not accurately model a

  1. A versatile rotary-stage high frequency probe station for studying magnetic films and devices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    He, Shikun; Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371; Meng, Zhaoliang

    We present a rotary-stage microwave probe station suitable for magnetic films and spintronic devices. Two stages, one for field rotation from parallel to perpendicular to the sample plane (out-of-plane) and the other intended for field rotation within the sample plane (in-plane) have been designed. The sample probes and micro-positioners are rotated simultaneously with the stages, which allows the field orientation to cover θ from 0{sup ∘} to 90{sup ∘} and φ from 0{sup ∘} to 360{sup ∘}. θ and φ being the angle between the direction of current flow and field in a out-of-plane and an in-plane rotation, respectively. Themore » operation frequency is up to 40 GHz and the magnetic field up to 1 T. The sample holder vision system and probe assembly are compactly designed for the probes to land on a wafer with diameter up to 3 cm. Using homemade multi-pin probes and commercially available high frequency probes, several applications including 4-probe DC measurements, the determination of domain wall velocity, and spin transfer torque ferromagnetic resonance are demonstrated.« less

  2. Study of an External Neutron Source for an Accelerator-Driven System using the PHITS Code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sugawara, Takanori; Iwasaki, Tomohiko; Chiba, Takashi

    A code system for the Accelerator Driven System (ADS) has been under development for analyzing dynamic behaviors of a subcritical core coupled with an accelerator. This code system named DSE (Dynamics calculation code system for a Subcritical system with an External neutron source) consists of an accelerator part and a reactor part. The accelerator part employs a database, which is calculated by using PHITS, for investigating the effect related to the accelerator such as the changes of beam energy, beam diameter, void generation, and target level. This analysis method using the database may introduce some errors into dynamics calculations sincemore » the neutron source data derived from the database has some errors in fitting or interpolating procedures. In this study, the effects of various events are investigated to confirm that the method based on the database is appropriate.« less

  3. Saturn Uranus atmospheric entry probe mission spacecraft system definition study

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The modifications required of the Pioneer F/G spacecraft design for it to deliver an atmospheric entry probe to the planets Saturn and Uranus are investigated. It is concluded that it is feasible to conduct such a mission within the constraints and interfaces defined. The spacecraft required to perform the mission is derived from the Pioneer F/G design, and the modifications required are generally routinely conceived and executed. The entry probe is necessarily a new design, although it draws on the technology of past, present, and imminent programs of planetary atmospheric investigations.

  4. Public Data Set: Radially Scanning Magnetic Probes to Study Local Helicity Injection Dynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Richner, Nathan J; Bongard, Michael W; Fonck, Raymond J

    This data set contains openly-documented, machine readable digital research data corresponding to figures published in N.J. Richner et al., 'Radially Scanning Magnetic Probes to Study Local Helicity Injection Dynamics,' accepted for publication in Rev. Sci. Instrum (2018).

  5. Standard Practices for Usage of Inductive Magnetic Field Probes with Application to Electric Propulsion Testing

    NASA Technical Reports Server (NTRS)

    Polzin, Kurt A.; Hill, Carrie S.

    2013-01-01

    Inductive magnetic field probes (also known as B-dot probes and sometimes as B-probes or magnetic probes) are useful for performing measurements in electric space thrusters and various plasma accelerator applications where a time-varying magnetic field is present. Magnetic field probes have proven to be a mainstay in diagnosing plasma thrusters where changes occur rapidly with respect to time, providing the means to measure the magnetic fields produced by time-varying currents and even an indirect measure of the plasma current density through the application of Ampère's law. Examples of applications where this measurement technique has been employed include pulsed plasma thrusters and quasi-steady magnetoplasmadynamic thrusters. The Electric Propulsion Technical Committee (EPTC) of the American Institute of Aeronautics and Astronautics (AIAA) was asked to assemble a Committee on Standards (CoS) for Electric Propulsion Testing. The assembled CoS was tasked with developing Standards and Recommended Practices for various diagnostic techniques used in the evaluation of plasma thrusters. These include measurements that can yield either global information related to a thruster and its performance or detailed, local data related to the specific physical processes occurring in the plasma. This paper presents a summary of the standard, describing the preferred methods for fabrication, calibration, and usage of inductive magnetic field probes for use in diagnosing plasma thrusters. Inductive magnetic field probes (also called B-dot probes throughout this document) are commonly used in electric propulsion (EP) research and testing to measure unsteady magnetic fields produced by time-varying currents. The B-dot probe is relatively simple in construction, and requires minimal cost, making it a low-cost technique that is readily accessible to most researchers. While relatively simple, the design of a B-dot probe is not trivial and there are many opportunities for errors in

  6. Mechanical Stability Study for Integrable Optics Test Accelerator at Fermilab

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McGee, Mike; Andrews, Richard; Carlson, Kermit

    2016-07-01

    The Integrable Optics Test Accelerator (IOTA) is proposed for operation at Fermilab. The goal of IOTA is to create practical nonlinear accelerator focusing systems with a large frequency spread and stable particle motion. The IOTA is a 40 m circumference, 150 MeV (e-), 2.5 MeV (p⁺) diagnostic test ring. A heavy low frequency steel floor girder is proposed as the primary tier for IOTA device component support. Two design lengths; (8) 4 m and (2) 2.8 m long girders with identical cross section completely encompass the ring. This study focuses on the 4 m length girder and the development ofmore » a working prototype. Hydrostatic Level Sensor (HLS), temperature, metrology and fast motion measurements characterize the anticipated mechanical stability of the IOTA ring.« less

  7. Early Acceleration of Mathematics Students and its Effect on Growth in Self-esteem: A Longitudinal Study

    NASA Astrophysics Data System (ADS)

    Ma, Xin

    2002-11-01

    The Longitudinal Study of American Youth (LSAY) database was employed to examine the educational practice of early acceleration of students of mathematics on the development of their self-esteem across the entire secondary grade levels. Students were classified into three different academic categories (gifted, honors, and regular). Results indicated that, in terms of the development of their self-esteem, gifted students benefited from early acceleration, honors students neither benefited nor were harmed by early acceleration, and regular students were harmed by early acceleration. Early acceleration in mathematics promoted significant growth in self-esteem among gifted male students and among gifted, honors, and regular minority students. When students were accelerated, schools showed similar average growth in self-esteem among gifted students and regular students and a large effect of general support for mathematics on the average growth in self-esteem among honors students.

  8. Plasma Accelerator Development for Dynamic Formation of Plasma Liners: A Status Report

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Eskridge, Richard; Martin, Adam; Smith, James; Lee, Michael; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    An experimental plasma accelerator for magnetic target fusion (MTF) applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a pulsed plasma thruster and has been tested experimentally and plasma jet velocities of approximately 50 km/sec have been obtained. The plasma jet structure has been photographed with 10 ns exposure times to reveal a stable and repeatable plasma structure. Data for velocity profile information has been obtained using light pipes embedded in the gun walls to record the plasma transit at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter is being characterized and future work for second generation "ultra-low jitter" gun development is being identified.

  9. Highly anisotropic mobility in solution processed TIPS-pentacene film studied by independently driven four GaIn probes

    NASA Astrophysics Data System (ADS)

    Yoshimoto, Shinya; Takahashi, Kohtaro; Suzuki, Mitsuharu; Yamada, Hiroko; Miyahara, Ryosuke; Mukai, Kozo; Yoshinobu, Jun

    2017-08-01

    We have studied in-plane anisotropy in the field-effect mobility of solution-processed organic semiconductor 6,13-bis(triisopropylsilylethynyl)pentacene by using independently driven four gallium indium (Ga-In) probes. Liquid-metal Ga-In probes are highly effective for reproducible conductivity measurements of organic thin films. We demonstrated that a high mobility anisotropy of 44 was obtained by using a square four-probe method and a feedback circuit to keep the channel potential constant. The present method minimized the influences of the contact resistance and the insensitivity of anisotropy in a linear arrangement in two-dimensional field-effect transistors.

  10. Joint kinematics and kinetics of overground accelerated running versus running on an accelerated treadmill

    PubMed Central

    Van Caekenberghe, Ine; Segers, Veerle; Aerts, Peter; Willems, Patrick; De Clercq, Dirk

    2013-01-01

    Literature shows that running on an accelerated motorized treadmill is mechanically different from accelerated running overground. Overground, the subject has to enlarge the net anterior–posterior force impulse proportional to acceleration in order to overcome linear whole body inertia, whereas on a treadmill, this force impulse remains zero, regardless of belt acceleration. Therefore, it can be expected that changes in kinematics and joint kinetics of the human body also are proportional to acceleration overground, whereas no changes according to belt acceleration are expected on a treadmill. This study documents kinematics and joint kinetics of accelerated running overground and running on an accelerated motorized treadmill belt for 10 young healthy subjects. When accelerating overground, ground reaction forces are characterized by less braking and more propulsion, generating a more forward-oriented ground reaction force vector and a more forwardly inclined body compared with steady-state running. This change in body orientation as such is partly responsible for the changed force direction. Besides this, more pronounced hip and knee flexion at initial contact, a larger hip extension velocity, smaller knee flexion velocity and smaller initial plantarflexion velocity are associated with less braking. A larger knee extension and plantarflexion velocity result in larger propulsion. Altogether, during stance, joint moments are not significantly influenced by acceleration overground. Therefore, we suggest that the overall behaviour of the musculoskeletal system (in terms of kinematics and joint moments) during acceleration at a certain speed remains essentially identical to steady-state running at the same speed, yet acting in a different orientation. However, because acceleration implies extra mechanical work to increase the running speed, muscular effort done (in terms of power output) must be larger. This is confirmed by larger joint power generation at the level

  11. Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

    PubMed Central

    Naganathan, Saranga; Grunbeck, Amy; Tian, He; Huber, Thomas; Sakmar, Thomas P.

    2013-01-01

    To facilitate structural and dynamic studies of G protein-coupled receptor (GPCR) signaling complexes, new approaches are required to introduce informative probes or labels into expressed receptors that do not perturb receptor function. We used amber codon suppression technology to genetically-encode the unnatural amino acid, p-azido-L-phenylalanine (azF) at various targeted positions in GPCRs heterologously expressed in mammalian cells. The versatility of the azido group is illustrated here in different applications to study GPCRs in their native cellular environment or under detergent solubilized conditions. First, we demonstrate a cell-based targeted photocrosslinking technology to identify the residues in the ligand-binding pocket of GPCR where a tritium-labeled small-molecule ligand is crosslinked to a genetically-encoded azido amino acid. We then demonstrate site-specific modification of GPCRs by the bioorthogonal Staudinger-Bertozzi ligation reaction that targets the azido group using phosphine derivatives. We discuss a general strategy for targeted peptide-epitope tagging of expressed membrane proteins in-culture and its detection using a whole-cell-based ELISA approach. Finally, we show that azF-GPCRs can be selectively tagged with fluorescent probes. The methodologies discussed are general, in that they can in principle be applied to any amino acid position in any expressed GPCR to interrogate active signaling complexes. PMID:24056801

  12. Demonstrated Performance of the Solar Probe Cup

    NASA Astrophysics Data System (ADS)

    Case, A. W.; Kasper, J. C.; Korreck, K. E.; Stevens, M. L.; Daigneau, P.; Freeman, M.; Caldwell, D.; Gauron, T.; Wright, K. H.; Bergner, H.; Cirtain, J. W.; Larson, D.; Brodu, E.; Balat-Pichelin, M.

    2013-12-01

    The Solar Probe Cup (SPC) is a Faraday Cup being developed for the Solar Probe Plus (SPP) mission. SPP will be the first spacecraft to directly measure the solar environment near the Alfven point in the atmosphere of the Sun, approaching to within 10 solar radii of the center of the Sun. In order to make the observations of radially flowing solar wind needed to address questions of coronal and solar wind heating and acceleration, SPC must operate while looking directly at the Sun. As a result, SPC will face a harsh and unprecidented environment, with component temperatures exceeding 1000C at closest approach. SPC is similar in design and operation to the two Faraday Cup instruments on the Wind spacecraft, which have been making stable measurements of the solar wind near Earth for two decades, with two key differences. SPC must survive and operate at extreme temperatures due to the levels of solar flux near the Sun, and it must record the solar wind approximately one thousand times faster than the instruments on Wind to keep up with the rapid variations expected near the Sun. We present results of a demonstration model of SPC operated in laboratory reproductions of the near-Sun environment. In the last year, SPC has been exposed to simulated encounter solar fluxes and resulting temperature profiles using a vaccum chamber and modified IMAX film projectors. In addition, SPC has been exposed to realistic ion beams. We show that SPC can operate in these environments, and make the measurements required for the sucess of the Solar Probe mission. Based on the performance of our prototype, the expected cadence and sensitivity of SPC will be discussed, with a focus on its ability to distinguish between models of heating in the solar corona.

  13. Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joshi, Chan; Mori, W.

    2013-10-21

    This is the final report on the DOE grant number DE-FG02-92ER40727 titled, “Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators.” During this grant period the UCLA program on Advanced Plasma Based Accelerators, headed by Professor C. Joshi has made many key scientific advances and trained a generation of students, many of whom have stayed in this research field and even started research programs of their own. In this final report however, we will focus on the last three years of the grant and report on the scientific progress made in each of the four tasksmore » listed under this grant. Four tasks are focused on: Plasma Wakefield Accelerator Research at FACET, SLAC National Accelerator Laboratory, In House Research at UCLA’s Neptune and 20 TW Laser Laboratories, Laser-Wakefield Acceleration (LWFA) in Self Guided Regime: Experiments at the Callisto Laser at LLNL, and Theory and Simulations. Major scientific results have been obtained in each of the four tasks described in this report. These have led to publications in the prestigious scientific journals, graduation and continued training of high quality Ph.D. level students and have kept the U.S. at the forefront of plasma-based accelerators research field.« less

  14. First muon acceleration using a radio-frequency accelerator

    NASA Astrophysics Data System (ADS)

    Bae, S.; Choi, H.; Choi, S.; Fukao, Y.; Futatsukawa, K.; Hasegawa, K.; Iijima, T.; Iinuma, H.; Ishida, K.; Kawamura, N.; Kim, B.; Kitamura, R.; Ko, H. S.; Kondo, Y.; Li, S.; Mibe, T.; Miyake, Y.; Morishita, T.; Nakazawa, Y.; Otani, M.; Razuvaev, G. P.; Saito, N.; Shimomura, K.; Sue, Y.; Won, E.; Yamazaki, T.

    2018-05-01

    Muons have been accelerated by using a radio-frequency accelerator for the first time. Negative muonium atoms (Mu- ), which are bound states of positive muons (μ+) and two electrons, are generated from μ+'s through the electron capture process in an aluminum degrader. The generated Mu- 's are initially electrostatically accelerated and injected into a radio-frequency quadrupole linac (RFQ). In the RFQ, the Mu- 's are accelerated to 89 keV. The accelerated Mu- 's are identified by momentum measurement and time of flight. This compact muon linac opens the door to various muon accelerator applications including particle physics measurements and the construction of a transmission muon microscope.

  15. Ion acceleration in a helicon source due to the self-bias effect

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wiebold, Matt; Sung, Yung-Ta; Scharer, John E.

    2012-05-15

    Time-averaged plasma potential differences up to 165 V over several hundred Debye lengths are observed in low pressure (p{sub n} < 1 mTorr) expanding argon plasmas in the Madison Helicon eXperiment (MadHeX). The potential gradient leads to ion acceleration greater than that predicted by ambipolar expansion, exceeding E{sub i} Almost-Equal-To 7 kT{sub e} in some cases. RF power up to 500 W at 13.56 MHz is supplied to a half-turn, double-helix antenna in the presence of a nozzle magnetic field, adjustable up to 1 kG. A retarding potential analyzer (RPA) measures the ion energy distribution function (IEDF) and a sweptmore » emissive probe measures the plasma potential. Single and double probes measure the electron density and temperature. Two distinct mode hops, the capacitive-inductive (E-H) and inductive-helicon (H-W) transitions, are identified by jumps in density as RF power is increased. In the capacitive (E) mode, large fluctuations of the plasma potential (V{sub p-p} Greater-Than-Or-Equivalent-To 140V, V{sub p-p}/V{sub p} Almost-Equal-To 150%) exist at the RF frequency and its harmonics. The more mobile electrons can easily respond to RF-timescale gradients in the plasma potential whereas the inertially constrained ions cannot, leading to an initial flux imbalance and formation of a self-bias voltage between the source and expansion chambers. In the capacitive mode, the ion acceleration is not well described by an ambipolar relation, while in the inductive and helicon modes the ion acceleration more closely follows an ambipolar relation. The scaling of the potential gradient with the argon flow rate and RF power are investigated, with the largest potential gradients observed for the lowest flow rates in the capacitive mode. The magnitude of the self-bias voltage agrees with that predicted for RF self-bias at a wall. Rapid fluctuations in the plasma potential result in a time-dependent axial electron flux that acts to 'neutralize' the accelerated ion

  16. Hydrophobic pocket targeting probes for enteroviruses

    NASA Astrophysics Data System (ADS)

    Martikainen, Mari; Salorinne, Kirsi; Lahtinen, Tanja; Malola, Sami; Permi, Perttu; Häkkinen, Hannu; Marjomäki, Varpu

    2015-10-01

    , the probe may be released upon virus uncoating. Our results collectively thus show that the gold and fluorescently labeled probes may be used to track and visualize the studied enteroviruses during the early phases of infection opening new avenues to follow virus uncoating in cells.Visualization and tracking of viruses without compromising their functionality is crucial in order to understand virus targeting to cells and tissues, and to understand the subsequent subcellular steps leading to virus uncoating and replication. Enteroviruses are important human pathogens causing a vast number of acute infections, and are also suggested to contribute to the development of chronic diseases like type I diabetes. Here, we demonstrate a novel method to target site-specifically the hydrophobic pocket of enteroviruses. A probe, a derivative of Pleconaril, was developed and conjugated to various labels that enabled the visualization of enteroviruses under light and electron microscopes. The probe mildly stabilized the virus particle by increasing the melting temperature by 1-3 degrees, and caused a delay in the uncoating of the virus in the cellular endosomes, but could not however inhibit the receptor binding, cellular entry or infectivity of the virus. The hydrophobic pocket binding moiety of the probe was shown to bind to echovirus 1 particle by STD and tr-NOESY NMR methods. Furthermore, binding to echovirus 1 and Coxsackievirus A9, and to a lesser extent to Coxsackie virus B3 was verified by using a gold nanocluster labeled probe by TEM analysis. Molecular modelling suggested that the probe fits the hydrophobic pockets of EV1 and CVA9, but not of CVB3 as expected, correlating well with the variations in the infectivity and stability of the virus particles. EV1 conjugated to the fluorescent dye labeled probe was efficiently internalized into the cells. The virus-fluorescent probe conjugate accumulated in the cytoplasmic endosomes and caused infection starting from 6 hours

  17. Optical imaging probes in oncology

    PubMed Central

    Martelli, Cristina; Dico, Alessia Lo; Diceglie, Cecilia; Lucignani, Giovanni; Ottobrini, Luisa

    2016-01-01

    Cancer is a complex disease, characterized by alteration of different physiological molecular processes and cellular features. Keeping this in mind, the possibility of early identification and detection of specific tumor biomarkers by non-invasive approaches could improve early diagnosis and patient management. Different molecular imaging procedures provide powerful tools for detection and non-invasive characterization of oncological lesions. Clinical studies are mainly based on the use of computed tomography, nuclear-based imaging techniques and magnetic resonance imaging. Preclinical imaging in small animal models entails the use of dedicated instruments, and beyond the already cited imaging techniques, it includes also optical imaging studies. Optical imaging strategies are based on the use of luminescent or fluorescent reporter genes or injectable fluorescent or luminescent probes that provide the possibility to study tumor features even by means of fluorescence and luminescence imaging. Currently, most of these probes are used only in animal models, but the possibility of applying some of them also in the clinics is under evaluation. The importance of tumor imaging, the ease of use of optical imaging instruments, the commercial availability of a wide range of probes as well as the continuous description of newly developed probes, demonstrate the significance of these applications. The aim of this review is providing a complete description of the possible optical imaging procedures available for the non-invasive assessment of tumor features in oncological murine models. In particular, the characteristics of both commercially available and newly developed probes will be outlined and discussed. PMID:27145373

  18. First Evaluation of the New Thin Convex Probe Endobronchial Ultrasound Scope: A Human Ex Vivo Lung Study.

    PubMed

    Patel, Priya; Wada, Hironobu; Hu, Hsin-Pei; Hirohashi, Kentaro; Kato, Tatsuya; Ujiie, Hideki; Ahn, Jin Young; Lee, Daiyoon; Geddie, William; Yasufuku, Kazuhiro

    2017-04-01

    Endobronchial ultrasonography (EBUS)-guided transbronchial needle aspiration allows for sampling of mediastinal lymph nodes. The external diameter, rigidity, and angulation of the convex probe EBUS renders limited accessibility. This study compares the accessibility and transbronchial needle aspiration capability of the prototype thin convex probe EBUS against the convex probe EBUS in human ex vivo lungs rejected for transplant. The prototype thin convex probe EBUS (BF-Y0055; Olympus, Tokyo, Japan) with a thinner tip (5.9 mm), greater upward angle (170 degrees), and decreased forward oblique direction of view (20 degrees) was compared with the current convex probe EBUS (6.9-mm tip, 120 degrees, and 35 degrees, respectively). Accessibility and transbronchial needle aspiration capability was assessed in ex vivo human lungs declined for lung transplant. The distance of maximum reach and sustainable endoscopic limit were measured. Transbronchial needle aspiration capability was assessed using the prototype 25G aspiration needle in segmental lymph nodes. In all evaluated lungs (n = 5), the thin convex probe EBUS demonstrated greater reach and a higher success rate, averaging 22.1 mm greater maximum reach and 10.3 mm further endoscopic visibility range than convex probe EBUS, and could assess selectively almost all segmental bronchi (98% right, 91% left), demonstrating nearly twice the accessibility as the convex probe EBUS (48% right, 47% left). The prototype successfully enabled cytologic assessment of subsegmental lymph nodes with adequate quality using the dedicated 25G aspiration needle. Thin convex probe EBUS has greater accessibility to peripheral airways in human lungs and is capable of sampling segmental lymph nodes using the aspiration needle. That will allow for more precise assessment of N1 nodes and, possibly, intrapulmonary lesions normally inaccessible to the conventional convex probe EBUS. Copyright © 2017 The Society of Thoracic Surgeons. Published

  19. Use of DNA probes to study tetracycline resistance determinants in gram-negative bacteria from swine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, C.Y.

    1989-01-01

    Specific {sup 32}P-labeled DNA probes were prepared and used to evaluate the distribution of tetracycline resistance determinants carried by gram-negative enteric bacteria isolated from pigs in 3 swine herds with different histories of antibiotic exposure. Plasmid DNA, ranging in size from 2.1 to 186 Kb, was observed in over 84% of 114 isolates studied. Two of 78 tetracycline resistant strains did not harbor plasmids. The DNA probes were isolated from plasmids pSL18, pRT29/Tn10, pBR322 and pSL106, respectively, and they represented class A, B, C and D tetracycline resistance determinants. Hybridization conditions using 0.5X SSPE at 65{degrees}C minimize cross-hybridization between themore » different class of tetracycline resistance genes. Cross-hybridization between class A and class C determinants could be distinguished by simultaneous comparison of the intensity of their hybridization signals. Plasmids from over 44% of the tetracycline resistant isolates did not hybridize to DNA probes for the determinants tested. Class B determinant occurred more frequently than class A or C. None of the isolates hybridized with the class D probe.« less

  20. Small Next-Generation Atmospheric Probe (SNAP) Concept

    NASA Technical Reports Server (NTRS)

    Sayanagi, K. M.; Dillman, R. A.; Simon, A. A.; Atkinson, D. H.; Wong, M. H.; Spilker, T. R.; Saikia, S.; Li, J.; Hope, D.

    2017-01-01

    We present the Small Next-Generation Atmospheric Probe (SNAP) as a secondary payload concept for future missions to giant planets. As a case study, we examine the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flag-ship mission; in combination with the missions main probe, SNAP would perform atmospheric in-situ measurements at a second location.

  1. Functionalized nanoparticle probes for protein detection

    NASA Astrophysics Data System (ADS)

    Park, Do Hyun; Lee, Jae-Seung

    2015-05-01

    In this Review, we discuss representative studies of recent advances in the development of nanoparticle-based protein detection methods, with a focus on the properties and functionalization of nanoparticle probes, as well as their use in detection schemes. We have focused on functionalized nanoparticle probes because they offer a number of advantages over conventional assays and because their use for detecting protein targets for diagnostic purposed has been demonstrated. In this report, we discuss nanoparticle probes classified by material type (gold, silver, silica, semiconductor, carbon, and virus) and surface functionality (antibody, aptamer, and DNA), which play a critical role in enhancing the sensitivity, selectivity, and efficiency of the detection systems. In particular, the synergistic function of each component of the nanoparticle probe is emphasized in terms of specific chemical and physical properties. This research area is in its early stages with many milestones to reach before nanoparticle probes are successfully applied in the field; however, the substantial ongoing efforts of researchers underline the great promise offered by nanoparticlebased probes for future applications. [Figure not available: see fulltext.

  2. PARTICLE ACCELERATOR

    DOEpatents

    Teng, L.C.

    1960-01-19

    ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

  3. Study of Some Planetary Atmospheres Features by Probe Entry and Descent Simulations

    NASA Technical Reports Server (NTRS)

    Gil, P. J. S.; Rosa, P. M. B.

    2005-01-01

    Characterization of planetary atmospheres is analyzed by its effects in the entry and descent trajectories of probes. Emphasis is on the most important variables that characterize atmospheres e.g. density profile with altitude. Probe trajectories are numerically determined with ENTRAP, a developing multi-purpose computational tool for entry and descent trajectory simulations capable of taking into account many features and perturbations. Real data from Mars Pathfinder mission is used. The goal is to be able to determine more accurately the atmosphere structure by observing real trajectories and what changes are to expect in probe descent trajectories if atmospheres have different properties than the ones assumed initially.

  4. Pump-probe Kelvin-probe force microscopy: Principle of operation and resolution limits

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Murawski, J.; Graupner, T.; Milde, P., E-mail: peter.milde@tu-dresden.de

    Knowledge on surface potential dynamics is crucial for understanding the performance of modern-type nanoscale devices. We describe an electrical pump-probe approach in Kelvin-probe force microscopy that enables a quantitative measurement of dynamic surface potentials at nanosecond-time and nanometer-length scales. Also, we investigate the performance of pump-probe Kelvin-probe force microscopy with respect to the relevant experimental parameters. We exemplify a measurement on an organic field effect transistor that verifies the undisturbed functionality of our pump-probe approach in terms of simultaneous and quantitative mapping of topographic and electronic information at a high lateral and temporal resolution.

  5. ProbeZT: Simulation of transport coefficients of molecular electronic junctions under environmental effects using Büttiker's probes

    NASA Astrophysics Data System (ADS)

    Korol, Roman; Kilgour, Michael; Segal, Dvira

    2018-03-01

    We present our in-house quantum transport package, ProbeZT. This program provides linear response coefficients: electrical and electronic thermal conductances, as well as the thermopower of molecular junctions in which electrons interact with the surrounding thermal environment. Calculations are performed based on the Büttiker probe method, which introduces decoherence, energy exchange and dissipation effects phenomenologically using virtual electrode terminals called probes. The program can realize different types of probes, each introducing various environmental effects, including elastic and inelastic scattering of electrons. The molecular system is described by an arbitrary tight-binding Hamiltonian, allowing the study of different geometries beyond simple one-dimensional wires. Applications of the program to study the thermoelectric performance of molecular junctions are illustrated. The program also has a built-in functionality to simulate electron transport in double-stranded DNA molecules based on a tight-binding (ladder) description of the junction.

  6. A Common Probe Design for Multiple Planetary Destinations

    NASA Technical Reports Server (NTRS)

    Hwang, H. H.; Allen, G. A., Jr.; Alunni, A. I.; Amato, M. J.; Atkinson, D. H.; Bienstock, B. J.; Cruz, J. R.; Dillman, R. A.; Cianciolo, A. D.; Elliott, J. O.; hide

    2018-01-01

    Atmospheric probes have been successfully flown to planets and moons in the solar system to conduct in situ measurements. They include the Pioneer Venus multi-probes, the Galileo Jupiter probe, and Huygens probe. Probe mission concepts to five destinations, including Venus, Jupiter, Saturn, Uranus, and Neptune, have all utilized similar-shaped aeroshells and concept of operations, namely a 45-degree sphere cone shape with high density heatshield material and parachute system for extracting the descent vehicle from the aeroshell. Each concept designed its probe to meet specific mission requirements and to optimize mass, volume, and cost. At the 2017 International Planetary Probe Workshop (IPPW), NASA Headquarters postulated that a common aeroshell design could be used successfully for multiple destinations and missions. This "common probe"� design could even be assembled with multiple copies, properly stored, and made available for future NASA missions, potentially realizing savings in cost and schedule and reducing the risk of losing technologies and skills difficult to sustain over decades. Thus the NASA Planetary Science Division funded a study to investigate whether a common probe design could meet most, if not all, mission needs to the five planetary destinations with extreme entry environments. The Common Probe study involved four NASA Centers and addressed these issues, including constraints and inefficiencies that occur in specifying a common design. Study methodology: First, a notional payload of instruments for each destination was defined based on priority measurements from the Planetary Science Decadal Survey. Steep and shallow entry flight path angles (EFPA) were defined for each planet based on qualification and operational g-load limits for current, state-of-the-art instruments. Interplanetary trajectories were then identified for a bounding range of EFPA. Next, 3-degrees-of-freedom simulations for entry trajectories were run using the entry state

  7. Probe penetration in relation to the connective tissue attachment level: influence of tine shape and probing force.

    PubMed

    Bulthuis, H M; Barendregt, D S; Timmerman, M F; Loos, B G; van der Velden, U

    1998-05-01

    Previous research has shown that probing force and probe tine shape influence the clinically assessed probing depth. The purpose of the present study was to investigate the effect of tine shape and probing force on probe penetration, in relation to the microscopically assessed attachment level in untreated periodontal disease. In 22 patients, scheduled for partial or full mouth tooth extraction and no history of periodontal treatment, 135 teeth were selected. At mesial and distal sites of the teeth reference marks were cut. Three probe tines, mounted in a modified Florida Probe handpiece, were tested: a tapered, a parallel and a ball-ended; tip-diameter 0.5 mm. The three tines were distributed at random over the sites. At each site increasing probing forces of 0.10 N, 0.15 N, 0.20 N, 0.25 N were used. After extraction, the teeth were cleaned and stained for connective tissue fiber attachment. The distance between the reference mark and the attachment level was determined using a stereomicroscope. The results showed that the parallel and ball-ended tine measured significantly beyond the microscopically assessed attachment level at all force levels; with increasing forces, the parallel tine measured 0.96 to 1.38 mm and the ball-ended tine 0.73 to 1.06 mm deeper. The tapered tine did not deviate significantly from the microscopic values at the forces of 0.15, 0.20 and 0.25 N. It can be concluded that for the optimal assessment of the attachment level in inflamed periodontal conditions, a tapered probe with a tip diameter of 0.5 mm and exerting a probing force of 0.25 N may be most suitable.

  8. Cognitive and functional correlates of accelerated long-term forgetting in temporal lobe epilepsy.

    PubMed

    Audrain, Samantha; McAndrews, Mary P

    2018-03-30

    While we know that hippocampal dysfunction is responsible for the memory deficits that patients with temporal lobe epilepsy exhibit at relatively short study-test delays, the role of this region in accelerated long-term forgetting (ALF) is not yet clear. In the present study, we probed the role of the hippocampus in ALF by directly comparing memory for associations to memory that could be supported by item recognition during a forced choice recognition task over delays ranging from 15-min to 72-h. We additionally examined resting-state functional connectivity between the hippocampus and cortical regions known to be involved in processing these types of stimuli, as well as the relationship between ALF and various clinical variables including structural abnormality in the hippocampus, lateralization of epileptic focus, presence of seizures across the retention period, and standardized composite memory scores. We found evidence of accelerated forgetting for item stimuli (but not associative stimuli) by 6 h post-learning, which became statistically reliable by 72-h. This finding suggests that unlike controls, patients were unable to utilize novelty to reject the incorrect object-scene pair. While none of the examined clinical variables were related to long-term forgetting, reduced resting-state functional connectivity between the affected anterior hippocampus and unaffected lateral temporal cortex predicted forgetting of item stimuli over the 72-h delay. Implications for the role of the hippocampus in accelerated long-term forgetting, and existing theories of systems consolidation in this context are discussed. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

  9. Probing of congenital nasolacrimal duct obstruction with dacryoendoscope

    PubMed Central

    Kato, Kumiko; Matsunaga, Koichi; Takashima, Yuko; Kondo, Mineo

    2014-01-01

    Background A congenital nasolacrimal duct obstruction (CNLDO) is a relatively common disease in infants. We evaluated the results of probing three patients with CNLDO, under direct view, with a dacryoendoscope. Methods Three cases of CNLDO were examined and treated by probing with a dacryoendoscope, under intravenous anesthesia. The diameter of the dacryoendoscope probe was 0.7 mm, and we were able to observe the inner walls of the lacrimal duct and able to guide the probe through the duct. Results In all cases, the site of obstruction was detected, and the probe was used to remove the obstruction. At 2 weeks after the removal of the obstruction, there was no epiphora or mucopurulent discharge in any of the cases. No complications were detected intra- and postoperatively. Conclusion Although only three cases were studied, we believe that probing with a dacryoendoscope is a safe and effective method of treating a CNLDO. More cases need to be studied. PMID:24876765

  10. Accelerated stability studies for moisture-induced aggregation of tetanus toxoid.

    PubMed

    Jain, Nishant Kumar; Roy, Ipsita

    2011-03-01

    The study was carried out to evaluate the effect of exposing solid tetanus toxoid to moisture in two different ways on the structure and function of the toxoid. Tetanus toxoid was exposed to moisture by (i) the addition of an optimized amount of buffer and (ii) incubation under an environment provided by a saturated solution of K(2)CrO(4.) The changes in the conformational, structural and antigenic properties of tetanus toxoid were measured and compared. Results show that even at a similar level of moisture-induced aggregation, the amounts of water absorbed by the two preparations of tetanus toxoid are different. Differences in antigenicity and changes in structure of the toxoid at primary, secondary and tertiary structure levels were seen. Although both conditions are used to mimic accelerated stability conditions in the laboratory, the final products are different in the two cases. Thus, conditions for 'accelerated stability studies' for therapeutic proteins need to be selected with care so that they resemble the fate of the actual product.

  11. Plasma Potential and Langmuir Probe Measurements in the Near-field Plume of the NASA 300M Hall Thruster

    NASA Technical Reports Server (NTRS)

    Herman, Daniel A; Shastry, Rohit; Huang, Wensheng; Soulas, George C.; KamHawi, Hani

    2012-01-01

    In order to aid in the design of high-power Hall thrusters and provide experimental validation for existing modeling efforts, plasma potential and Langmuir probe measurements were performed in the near-field plume of the NASA 300M Hall thruster. A probe array consisting of a Faraday probe, Langmuir probe, and emissive probe was used to interrogate the plume from approximately 0.1 - 2.0 DT,m downstream of the thruster exit plane at four operating conditions: 300 V, 400 V, and 500 V at 20 kW as well as 300 V at 10 kW. Results show that the acceleration zone and high-temperature region were contained within 0.3 DT,m from the exit plane at all operating conditions. Isothermal lines were shown to strongly follow magnetic field lines in the nearfield, with maximum temperatures ranging from 19 - 27 eV. The electron temperature spatial distribution created large drops in measured floating potentials in front of the magnetic pole surfaces where the plasma density was small, which suggests strong sheaths at these surfaces. The data taken have provided valuable information for future design and modeling validation, and complements ongoing internal measurement efforts on the NASA 300 M.

  12. Modeling the Insertion Mechanics of Flexible Neural Probes Coated with Sacrificial Polymers for Optimizing Probe Design

    PubMed Central

    Singh, Sagar; Lo, Meng-Chen; Damodaran, Vinod B.; Kaplan, Hilton M.; Kohn, Joachim; Zahn, Jeffrey D.; Shreiber, David I.

    2016-01-01

    Single-unit recording neural probes have significant advantages towards improving signal-to-noise ratio and specificity for signal acquisition in brain-to-computer interface devices. Long-term effectiveness is unfortunately limited by the chronic injury response, which has been linked to the mechanical mismatch between rigid probes and compliant brain tissue. Small, flexible microelectrodes may overcome this limitation, but insertion of these probes without buckling requires supporting elements such as a stiff coating with a biodegradable polymer. For these coated probes, there is a design trade-off between the potential for successful insertion into brain tissue and the degree of trauma generated by the insertion. The objective of this study was to develop and validate a finite element model (FEM) to simulate insertion of coated neural probes of varying dimensions and material properties into brain tissue. Simulations were performed to predict the buckling and insertion forces during insertion of coated probes into a tissue phantom with material properties of brain. The simulations were validated with parallel experimental studies where probes were inserted into agarose tissue phantom, ex vivo chick embryonic brain tissue, and ex vivo rat brain tissue. Experiments were performed with uncoated copper wire and both uncoated and coated SU-8 photoresist and Parylene C probes. Model predictions were found to strongly agree with experimental results (<10% error). The ratio of the predicted buckling force-to-predicted insertion force, where a value greater than one would ideally be expected to result in successful insertion, was plotted against the actual success rate from experiments. A sigmoidal relationship was observed, with a ratio of 1.35 corresponding to equal probability of insertion and failure, and a ratio of 3.5 corresponding to a 100% success rate. This ratio was dubbed the “safety factor”, as it indicated the degree to which the coating should be over

  13. A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

    PubMed Central

    van Thor, Jasper J.; Madsen, Anders

    2015-01-01

    In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to-noise (I/σI) must be addressed. For single-crystal studies under low absorbed dose conditions, it has been shown that the intrinsic pulse intensity stability as well as mode structure and jitter of this structure, significantly affect the crystallographic signal-to-noise. Here, geometrical parameters are theoretically explored for a three-beam scheme: X-ray probe, optical pump, X-ray probe (or “probe-pump-probe”) which will allow experimental determination of the photo-induced structure factor amplitude differences, ΔF, in a ratiometric manner, thereby internally referencing the intensity noise of the XFEL source. In addition to a non-collinear split-beam geometry which separates un-pumped and pumped diffraction patterns on an area detector, applying an additional convergence angle to both beams by focusing leads to integration over mosaic blocks in the case of well-ordered stationary protein crystals. Ray-tracing X-ray diffraction simulations are performed for an example using photoactive yellow protein crystals in order to explore the geometrical design parameters which would be needed. The specifications for an X-ray split and delay instrument that implements both an offset angle and focused beams are discussed, for implementation of a probe-pump-probe scheme at the European XFEL. We discuss possible extension of single crystal studies to serial femtosecond crystallography, particularly in view of the expected X-ray damage and ablation due to the first probe pulse. PMID:26798786

  14. A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    van Thor, Jasper J.; Madsen, Anders

    In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to-noise (I/σI) must be addressed. For single-crystal studies under low absorbed dose conditions, it has been shown that the intrinsic pulse intensity stability as well as mode structure and jitter of this structure, significantly affect the crystallographic signal-to-noise. Here, geometrical parameters are theoretically explored for a three-beam scheme: X-ray probe, optical pump, X-ray probe (or “probe-pump-probe”) which will allow experimental determination of the photo-induced structure factor amplitude differences, ΔF,more » in a ratiometric manner, thereby internally referencing the intensity noise of the XFEL source. In addition to a non-collinear split-beam geometry which separates un-pumped and pumped diffraction patterns on an area detector, applying an additional convergence angle to both beams by focusing leads to integration over mosaic blocks in the case of well-ordered stationary protein crystals. Ray-tracing X-ray diffraction simulations are performed for an example using photoactive yellow protein crystals in order to explore the geometrical design parameters which would be needed. The specifications for an X-ray split and delay instrument that implements both an offset angle and focused beams are discussed, for implementation of a probe-pump-probe scheme at the European XFEL. We discuss possible extension of single crystal studies to serial femtosecond crystallography, particularly in view of the expected X-ray damage and ablation due to the first probe pulse.« less

  15. A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

    DOE PAGES

    van Thor, Jasper J.; Madsen, Anders

    2015-01-01

    In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to-noise (I/σI) must be addressed. For single-crystal studies under low absorbed dose conditions, it has been shown that the intrinsic pulse intensity stability as well as mode structure and jitter of this structure, significantly affect the crystallographic signal-to-noise. Here, geometrical parameters are theoretically explored for a three-beam scheme: X-ray probe, optical pump, X-ray probe (or “probe-pump-probe”) which will allow experimental determination of the photo-induced structure factor amplitude differences, ΔF,more » in a ratiometric manner, thereby internally referencing the intensity noise of the XFEL source. In addition to a non-collinear split-beam geometry which separates un-pumped and pumped diffraction patterns on an area detector, applying an additional convergence angle to both beams by focusing leads to integration over mosaic blocks in the case of well-ordered stationary protein crystals. Ray-tracing X-ray diffraction simulations are performed for an example using photoactive yellow protein crystals in order to explore the geometrical design parameters which would be needed. The specifications for an X-ray split and delay instrument that implements both an offset angle and focused beams are discussed, for implementation of a probe-pump-probe scheme at the European XFEL. We discuss possible extension of single crystal studies to serial femtosecond crystallography, particularly in view of the expected X-ray damage and ablation due to the first probe pulse.« less

  16. Einstein Inflationary Probe (EIP)

    NASA Technical Reports Server (NTRS)

    Hinshaw, Gary

    2004-01-01

    I will discuss plans to develop a concept for the Einstein Inflation Probe: a mission to detect gravity waves from inflation via the unique signature they impart to the cosmic microwave background (CMB) polarization. A sensitive CMB polarization satellite may be the only way to probe physics at the grand-unified theory (GUT) scale, exceeding by 12 orders of magnitude the energies studied at the Large Hadron Collider. A detection of gravity waves would represent a remarkable confirmation of the inflationary paradigm and set the energy scale at which inflation occurred when the universe was a fraction of a second old. Even a strong upper limit to the gravity wave amplitude would be significant, ruling out many common models of inflation, and pointing to inflation occurring at much lower energy, if at all. Measuring gravity waves via the CMB polarization will be challenging. We will undertake a comprehensive study to identify the critical scientific requirements for the mission and their derived instrumental performance requirements. At the core of the study will be an assessment of what is scientifically and experimentally optimal within the scope and purpose of the Einstein Inflation Probe.

  17. The study of two-dimensional oscillations using a smartphone acceleration sensor: example of Lissajous curves

    NASA Astrophysics Data System (ADS)

    Tuset-Sanchis, Luis; Castro-Palacio, Juan C.; Gómez-Tejedor, José A.; Manjón, Francisco J.; Monsoriu, Juan A.

    2015-08-01

    A smartphone acceleration sensor is used to study two-dimensional harmonic oscillations. The data recorded by the free android application, Accelerometer Toy, is used to determine the periods of oscillation by graphical analysis. Different patterns of the Lissajous curves resulting from the superposition of harmonic motions are illustrated for three experiments. This work introduces an example of how two-dimensional oscillations can be easily studied with a smartphone acceleration sensor.

  18. Circumferential pressure probe

    NASA Technical Reports Server (NTRS)

    Holmes, Harlan K. (Inventor); Moore, Thomas C. (Inventor); Fantl, Andrew J. (Inventor)

    1989-01-01

    A probe for measuring circumferential pressure inside a body cavity is disclosed. In the preferred embodiment, a urodynamic pressure measurement probe for evaluating human urinary sphincter function is disclosed. Along the length of the probe are disposed a multiplicity of deformable wall sensors which typically comprise support tube sections with flexible side wall areas. These are arranged along the length of the probe in two areas, one just proximal to the tip for the sensing of fluid pressure inside the bladder, and five in the sensing section which is positioned within the urethra at the point at which the urinary sphincter constricts to control the flow of urine. The remainder of the length of the probe comprises multiple rigid support tube sections interspersed with flexible support tube sections in the form of bellows to provide flexibility.

  19. The methodology study of time accelerated irradiation of elastomers

    NASA Astrophysics Data System (ADS)

    Ito, Masayuki

    2005-07-01

    The article studied the methods how to shorten the irradiation time by increasing dose rate without changing the relationship between dose versus properties of degraded samples. The samples used were nine kinds of EPDM which have different compounding formula. The different dose of Co-γ ray was exposed to the samples. The maximum dose was 2 MGy. The reference condition to be compared with two short time test conditions is irradiation of 0.33 kGy/h at room temperature. Two methods shown below were studied as the time-accelerate irradiation conditions.

  20. The GalileoJupiter Probe Doppler Wind Experiment

    NASA Astrophysics Data System (ADS)

    Atkinson, D. H.

    2001-09-01

    The GalileoJupiter atmospheric entry probe was launched along with the Galileoorbiter spacecraft from Cape Canaveral in Florida, USA, on October 18, 1989. Following a cruise of greater than six years, the probe arrived at Jupiter on December 7, 1995. During its 57-minute descent, instruments on the probe studied the atmospheric composition and structure, the clouds, lightning, and energy structure of the upper Jovian atmosphere. One of the two radio channels over which the experiment data was transmitted to the orbiter was driven by an ultrastable oscillator. All motions of the probe and orbiter, including the speed of probe descent, Jupiter's rotation, and the atmospheric winds, contributed to a Doppler shift of the probe radio frequency. By accurately measuring the frequency of the probe radio signal, an accurate time history of the probe-orbiter relative motions could be reconstructed. Knowledge of the nominal probe and orbiter trajectories allowed the nominal Doppler shift to be removed from the probe radio frequency leaving a measurable frequency residual arising primarily from the zonal winds in Jupiter's atmosphere, and micromotions of the probe arising from probe spin, swing under the parachute, atmospheric turbulence, and aerodynamic effects. Assuming that the zonal horizontal winds dominate the residual probe motion, a profile of frequency residuals was generated. Inversion of the frequency residuals resulted in the first in situ measurements of the vertical profile of Jupiter's deep zonal winds. It is found that beneath 700 mb, the winds are strong and prograde, rising rapidly to 170 m/s between 1 and 4 bars. Beneath 4 bars to 21 bars, the depth at which the link with the probe was lost, the winds remain constant and strong. When corrections for the high temperatures encountered by the probe are considered, there is no evidence of diminishing or strengthening of the zonal winds in the deepest regions explored by the Galileoprobe. Following the wind

  1. A study of data analysis techniques for the multi-needle Langmuir probe

    NASA Astrophysics Data System (ADS)

    Hoang, H.; Røed, K.; Bekkeng, T. A.; Moen, J. I.; Spicher, A.; Clausen, L. B. N.; Miloch, W. J.; Trondsen, E.; Pedersen, A.

    2018-06-01

    In this paper we evaluate two data analysis techniques for the multi-needle Langmuir probe (m-NLP). The instrument uses several cylindrical Langmuir probes, which are positively biased with respect to the plasma potential in order to operate in the electron saturation region. Since the currents collected by these probes can be sampled at kilohertz rates, the instrument is capable of resolving the ionospheric plasma structure down to the meter scale. The two data analysis techniques, a linear fit and a non-linear least squares fit, are discussed in detail using data from the Investigation of Cusp Irregularities 2 sounding rocket. It is shown that each technique has pros and cons with respect to the m-NLP implementation. Even though the linear fitting technique seems to be better than measurements from incoherent scatter radar and in situ instruments, m-NLPs can be longer and can be cleaned during operation to improve instrument performance. The non-linear least squares fitting technique would be more reliable provided that a higher number of probes are deployed.

  2. Study of ablation and implosion stages in wire arrays using coupled ultraviolet and X-ray probing diagnostics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anderson, A. A.; Ivanov, V. V.; Astanovitskiy, A. L.

    2015-11-15

    Star and cylindrical wire arrays were studied using laser probing and X-ray radiography at the 1-MA Zebra pulse power generator at the University of Nevada, Reno. The Leopard laser provided backlighting, producing a laser plasma from a Si target which emitted an X-ray probing pulse at the wavelength of 6.65 Å. A spherically bent quartz crystal imaged the backlit wires onto X-ray film. Laser probing diagnostics at the wavelength of 266 nm included a 3-channel polarimeter for Faraday rotation diagnostic and two-frame laser interferometry with two shearing interferometers to study the evolution of the plasma electron density at the ablation and implosionmore » stages. Dynamics of the plasma density profile in Al wire arrays at the ablation stage were directly studied with interferometry, and expansion of wire cores was measured with X-ray radiography. The magnetic field in the imploding plasma was measured with the Faraday rotation diagnostic, and current was reconstructed.« less

  3. Efficacy of probing for children with congenital nasolacrimal duct obstruction: a retrospective study using fluorescein dye disappearance test and lacrimal sac echography.

    PubMed

    Steindler, Piero; Mantovani, Enrico; Incorvaia, Carlo; Parmeggiani, Francesco

    2009-06-01

    To evaluate B-scan echography for the assessment of lacrimal sac (LS) in pediatric epiphora secondary to congenital nasolacrimal duct obstruction (CNLDO), and to verify its predictive role in functional efficacy of nasolacrimal duct probing. Thirty-nine eyes of 23 consecutive children, treated with a single probing for persistent CNLDO-related epiphora, were retrospectively studied. These cases were investigated both collectively and considering two sub-groups: group A (ten patients [20 eyes] 13 months. Fluorescein dye disappearance test at 10 minutes (FDDT-10) and ultrasound examination of LS were performed before and after probing. An echographic LS scoring system (grade 0 = no LS enlargement; grade 1 = slight longitudinal LS enlargement; grade 2 = longitudinal and slight transverse LS enlargement; grade 3 = marked longitudinal and transverse LS enlargement) was introduced as a predictor of probing efficacy, estimating FDDT-10 modification between pre- and post-operative checks. Echographic LS evaluation was easily practicable without sedation. In the total cluster and in both age sub-groups, post-probing FDDT-10 decreased with respect to pre-probing value (p < 0.001). Post-probing LS score improved with respect to pre-probing check within the total cluster and group A (p < 0.05). Strong correlation between pre-probing LS alteration and functional probing failure was present in each studied cluster (all p values <0.0001). Within group B, a greater gain of post-probing FDDT-10 was more frequent in patients with a better pre-probing LS score, as well as in younger children (both p values <0.0001). In children with CNLDO-related epiphora, B-scan echography of the LS can represent a reliable and useful examination for a better understanding of the functional prognosis after probing treatment.

  4. Accelerator Science: Circular vs. Linear

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lincoln, Don

    Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

  5. Multispectral phloem-mobile probes: properties and applications.

    PubMed

    Knoblauch, Michael; Vendrell, Marc; de Leau, Erica; Paterlini, Andrea; Knox, Kirsten; Ross-Elliot, Tim; Reinders, Anke; Brockman, Stephen A; Ward, John; Oparka, Karl

    2015-04-01

    Using Arabidopsis (Arabidopsis thaliana) seedlings, we identified a range of small fluorescent probes that entered the translocation stream and were unloaded at the root tip. These probes had absorbance/emission maxima ranging from 367/454 to 546/576 nm and represent a versatile toolbox for studying phloem transport. Of the probes that we tested, naturally occurring fluorescent coumarin glucosides (esculin and fraxin) were phloem loaded and transported in oocytes by the sucrose transporter, AtSUC2. Arabidopsis plants in which AtSUC2 was replaced with barley (Hordeum vulgare) sucrose transporter (HvSUT1), which does not transport esculin in oocytes, failed to load esculin into the phloem. In wild-type plants, the fluorescence of esculin decayed to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labeling studies of phloem transport. We identified additional probes, such as carboxytetraethylrhodamine, a red fluorescent probe that, unlike esculin, was stable for several hours after phloem unloading and could be used to study phloem transport in Arabidopsis lines expressing green fluorescent protein. © 2015 American Society of Plant Biologists. All Rights Reserved.

  6. The Solar Probe Plus Mission: Humanity's First Visit to Our Star

    NASA Technical Reports Server (NTRS)

    Fox, N. J.; Velli, M. C.; Bale, S. D.; Decker, R.; Driesman, A.; Howard, R. A.; Kasper, J. C.; Kinnison, J.; Kusterer, M.; Lario, D.; hide

    2015-01-01

    Solar Probe Plus (SPP) will be the first spacecraft to fly into the low solar corona. SPPs main science goal is to determine the structure and dynamics of the Suns coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what processes accelerate energetic particles. Understanding these fundamental phenomena has been a top-priority science goal for over five decades, dating back to the 1958 Simpson Committee Report. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The mission design and the technology and engineering developments enable SPP to meet its science objectives to: (1) Trace the flow of energy that heats and accelerates the solar corona and solar wind; (2) Determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind; and (3) Explore mechanisms that accelerate and transport energetic particles. The SPP mission was confirmed in March 2014 and is under development as a part of NASAs Living with a Star (LWS) Program. SPP is scheduled for launch in mid-2018, and will perform 24 orbits over a 7-year nominal mission duration. Seven Venus gravity assists gradually reduce SPPs perihelion from 35 solar radii (RS) for the first orbit to less than 10 RS for the final three orbits. In this paper we present the science, mission concept and the baseline vehicle for SPP, and examine how the mission will address the key science questions.

  7. The Solar Probe Plus Mission: Humanity's First Visit to Our Star

    NASA Astrophysics Data System (ADS)

    Fox, N. J.; Velli, M. C.; Bale, S. D.; Decker, R.; Driesman, A.; Howard, R. A.; Kasper, J. C.; Kinnison, J.; Kusterer, M.; Lario, D.; Lockwood, M. K.; McComas, D. J.; Raouafi, N. E.; Szabo, A.

    2016-12-01

    Solar Probe Plus (SPP) will be the first spacecraft to fly into the low solar corona. SPP's main science goal is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what processes accelerate energetic particles. Understanding these fundamental phenomena has been a top-priority science goal for over five decades, dating back to the 1958 Simpson Committee Report. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The mission design and the technology and engineering developments enable SPP to meet its science objectives to: (1) Trace the flow of energy that heats and accelerates the solar corona and solar wind; (2) Determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind; and (3) Explore mechanisms that accelerate and transport energetic particles. The SPP mission was confirmed in March 2014 and is under development as a part of NASA's Living with a Star (LWS) Program. SPP is scheduled for launch in mid-2018, and will perform 24 orbits over a 7-year nominal mission duration. Seven Venus gravity assists gradually reduce SPP's perihelion from 35 solar radii (RS) for the first orbit to {<}10 RS for the final three orbits. In this paper we present the science, mission concept and the baseline vehicle for SPP, and examine how the mission will address the key science questions

  8. Studying the Structure and Dynamics of Biomolecules by Using Soluble Paramagnetic Probes

    PubMed Central

    Hocking, Henry G; Zangger, Klaus; Madl, Tobias

    2013-01-01

    Characterisation of the structure and dynamics of large biomolecules and biomolecular complexes by NMR spectroscopy is hampered by increasing overlap and severe broadening of NMR signals. As a consequence, the number of available NMR spectroscopy data is often sparse and new approaches to provide complementary NMR spectroscopy data are needed. Paramagnetic relaxation enhancements (PREs) obtained from inert and soluble paramagnetic probes (solvent PREs) provide detailed quantitative information about the solvent accessibility of NMR-active nuclei. Solvent PREs can be easily measured without modification of the biomolecule; are sensitive to molecular structure and dynamics; and are therefore becoming increasingly powerful for the study of biomolecules, such as proteins, nucleic acids, ligands and their complexes in solution. In this Minireview, we give an overview of the available solvent PRE probes and discuss their applications for structural and dynamic characterisation of biomolecules and biomolecular complexes. PMID:23836693

  9. Modular Rake of Pitot Probes

    NASA Technical Reports Server (NTRS)

    Dunlap, Timothy A.; Henry, Michael W.; Homyk, Raymond P.

    2004-01-01

    The figure presents selected views of a modular rake of 17 pitot probes for measuring both transient and steady-state pressures in a supersonic wind tunnel. In addition to pitot tubes visible in the figure, the probe modules contain (1) high-frequency dynamic-pressure transducers connected through wires to remote monitoring circuitry and (2) flow passages that lead to tubes that, in turn, lead to remote steady-state pressure transducers. Prior pitot-probe rakes were fabricated as unitary structures, into which the individual pitot probes were brazed. Repair or replacement of individual probes was difficult, costly, and time-consuming because (1) it was necessary to remove entire rakes in order to unbraze individual malfunctioning probes and (2) the heat of unbrazing a failed probe and of brazing a new probe in place could damage adjacent probes. In contrast, the modules in the present probe are designed to be relatively quickly and easily replaceable with no heating and, in many cases, without need for removal of the entire rake from the wind tunnel. To remove a malfunctioning probe, one first removes a screw-mounted V-cross-section cover that holds the probe and adjacent probes in place. Then one removes a screw-mounted cover plate to gain access to the steady-state pressure tubes and dynamicpressure wires. Next, one disconnects the tube and wires of the affected probe. Finally, one installs a new probe in the reverse of the aforementioned sequence. The wire connections can be made by soldering, but to facilitate removal and installation, they can be made via miniature plugs and sockets. The connections between the probe flow passages and the tubes leading to the remote pressure sensors can be made by use of any of a variety of readily available flexible tubes that can be easily pulled off and slid back on for removal and installation, respectively.

  10. Studies on probe measurements in presence of magnetic field in dust containing hydrogen plasma

    NASA Astrophysics Data System (ADS)

    Kalita, Deiji; Kakati, Bharat; Kausik, Siddhartha Sankar; Saikia, Bipul Kumar; Bandyopadhyay, Mainak

    2018-04-01

    The accuracy of plasma parameters measured by Langmuir probe in presence of magnetic field is studied in our present work. It is observed that the ratio of electron to ion saturation current shows almost identical behavior with that of unmagnetized hydrogen plasma when r L > 10 r p (here r L : Larmor radius and r p : probe radius). At magnetic field strength, B = 594 gauss, the electron temperature ( T e ) shows an overestimated value up to 35-40%, whereas at B ≤ 37 gauss, T e shows around ≤10% overestimated value w.r.t. unmagnetized case. A bi-Maxwellian electron energy probability function is observed for entire magnetic field range for both pristine and dust containing hydrogen plasma. The bulk (cold) electron collection by the Langmuir probe is strongly suppressed whereas the higher energetic electron collection remains unaffected in presence of magnetic field. In presence of dust grains, it is found that the low energy electron population decreases even more than the magnetized plasma and the high-energy tail slightly increases compared to the pristine plasma.

  11. Design study of an entry probe spectro-reflectometer

    NASA Technical Reports Server (NTRS)

    Sill, G. T.; Fink, U.

    1986-01-01

    A wind tunnel was built to simulate the rapid movement of an entry probe through the Jupiter atmosphere. Wind speeds range from 1 to 50 meters per second in a closed system. Wind velocity and temperature probes as well as a cryogenically cooled cold finger can be placed in the 6 inch diameter viewing section. The initial testing of the wind tunnel involved running sectional profiles through the observation port of air currents of 0.1 to 3.0 atmosphere. The velocity profile was very uniform throughout the cross section of the experimental port, with the exception of the wall effects. The deposition of cooled volatiles using the wind tunnel was not performed. However, measurements of the deposition of H2O ice on a cryogenically cooled thickness modulator were made under ambient conditions, namely room temperature and pressure. In the Frost Depositon Test Facility, ice deposition was measured at thicknesses of about a half millimeter and frost was produced whose thickness reflectivity could easily be measured by reflectance spectroscopy.

  12. Accelerator Science: Circular vs. Linear

    ScienceCinema

    Lincoln, Don

    2018-06-12

    Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

  13. Electron acceleration by an obliquely propagating electromagnetic wave in the regime of validity of the Fokker-Planck-Kolmogorov approach

    NASA Technical Reports Server (NTRS)

    Hizanidis, Kyriakos; Vlahos, L.; Polymilis, C.

    1989-01-01

    The relativistic motion of an ensemble of electrons in an intense monochromatic electromagnetic wave propagating obliquely in a uniform external magnetic field is studied. The problem is formulated from the viewpoint of Hamiltonian theory and the Fokker-Planck-Kolmogorov approach analyzed by Hizanidis (1989), leading to a one-dimensional diffusive acceleration along paths of constant zeroth-order generalized Hamiltonian. For values of the wave amplitude and the propagating angle inside the analytically predicted stochastic region, the numerical results suggest that the diffusion probes proceeds in stages. In the first stage, the electrons are accelerated to relatively high energies by sampling the first few overlapping resonances one by one. During that stage, the ensemble-average square deviation of the variable involved scales quadratically with time. During the second stage, they scale linearly with time. For much longer times, deviation from linear scaling slowly sets in.

  14. Mega-electron-volt ultrafast electron diffraction at SLAC National Accelerator Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weathersby, S. P.; Brown, G.; Chase, T. F.

    Ultrafast electron probes are powerful tools, complementary to x-ray free-electron lasers, used to study structural dynamics in material, chemical, and biological sciences. High brightness, relativistic electron beams with femtosecond pulse duration can resolve details of the dynamic processes on atomic time and length scales. SLAC National Accelerator Laboratory recently launched the Ultrafast Electron Diffraction (UED) and microscopy Initiative aiming at developing the next generation ultrafast electron scattering instruments. As the first stage of the Initiative, a mega-electron-volt (MeV) UED system has been constructed and commissioned to serve ultrafast science experiments and instrumentation development. The system operates at 120-Hz repetition ratemore » with outstanding performance. In this paper, we report on the SLAC MeV UED system and its performance, including the reciprocal space resolution, temporal resolution, and machine stability.« less

  15. Trunk Acceleration for Neuroprosthetic Control of Standing – a Pilot Study

    PubMed Central

    Audu, Musa L.; Kirsch, Robert F.; Triolo, Ronald J.

    2013-01-01

    This pilot study investigated the potential of using trunk acceleration feedback control of center of pressure (COP) against postural disturbances with a standing neuroprosthesis following paralysis. Artificial neural networks (ANNs) were trained to use three-dimensional trunk acceleration as input to predict changes in COP for able-bodied subjects undergoing perturbations during bipedal stance. Correlation coefficients between ANN predictions and actual COP ranged from 0.67 to 0.77. An ANN trained across all subject-normalized data was used to drive feedback control of ankle muscle excitation levels for a computer model representing a standing neuroprosthesis user. Feedback control reduced average upper-body loading during perturbation onset and recovery by 42% and peak loading by 29% compared to optimal, constant excitation. PMID:21975251

  16. A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes

    PubMed Central

    Wang, Dan Ohtan; Matsuno, Hitomi; Ikeda, Shuji; Nakamura, Akiko; Yanagisawa, Hiroyuki; Hayashi, Yasunori; Okamoto, Akimitsu

    2012-01-01

    Fluorescence in situ hybridization (FISH) is a powerful tool used in karyotyping, cytogenotyping, cancer diagnosis, species specification, and gene-expression analysis. Although widely used, conventional FISH protocols are cumbersome and time consuming. We have now developed a FISH method using exciton-controlled hybridization-sensitive fluorescent oligodeoxynucleotide (ECHO) probes. ECHO–FISH uses a 25-min protocol from fixation to mounting that includes no stringency washing steps. We use ECHO–FISH to detect both specific DNA and RNA sequences with multicolor probes. ECHO–FISH is highly reproducible, stringent, and compatible with other fluorescent cellular labeling techniques. The resolution allows detection of intranuclear speckles of poly(A) RNA in HeLa cells and dissociated hippocampal primary cultures, and mRNAs in the distal dendrites of hippocampal neurons. We also demonstrate detection of telomeric and centromeric DNA on metaphase mouse chromosomes. The simplicity of the ECHO–FISH method will likely accelerate cytogenetic and gene-expression analysis with high resolution. PMID:22101241

  17. Probing the Active Galactic Nuclei using optical spectroscopy

    NASA Astrophysics Data System (ADS)

    Vivek, M.

    Variability studies offer one of the best tools for understanding the physical conditions present in regions close to the central engine in an AGN. We probed the various properties of AGN through time variability studies of spectral lines in the optical wavelengths using the 2m telescope in IUCAA Girawali observatory. The absorption line variability studies are mainly concentrated in understanding the nature of outflows in quasars. Quasar outflows have a huge impact on the evolution of central supermassive blackholes, their host galaxies and the surrounding intergalactic medium. Studying the variability in these Broad Absorption Lines (BALs) can help us understand the structure, evolution, and basic physical properties of these outflows. We conducted a repeated Low ionization BAL monitoring program with 27 LoBALs (Low Ionization BALs) at z 0.3-2.1 covering timescales from 3.22 to 7.69 years in the quasar rest frame. We see a variety of phenomena, including some BALs that either appeared or disappeared completely and some BALs which do not vary over the observation period. In one case, the excited fine structure lines have changed dramatically. One source shows signatures of radiative acceleration. Here, we present the results from this program. Emission line studies are concentrated in understanding the peculiar characteristics of a dual-AGN source SDSS J092712.64+294344.0.

  18. Study of borehole probing methods to improve the ground characterization

    NASA Astrophysics Data System (ADS)

    Naeimipour, Ali

    partially condition of discontinuities. Two of the more promising tools have been tested during this project, which are QL40OBI Optical TV and Slim Borehole Scanner (SBS) manufacture by ALT-Mount Sopris and DMT, respectively. The field experiment with QL40OBI showed that the images generated for downward and sub-horizontal boreholes are of good quality and can be used to evaluate the joint conditions. However, this device is not suitable for use inside the upward drillholes. The Slim Borehole Scanner (SBS) manufactured by DMT in Germany has the required features for borescoping the roofbolt holes. This includes the ease of operation and suitable geometry along with an unwrapped 360-degree picture of the borehole wall. This instrument was concluded to be the best option yet for obtaining images from boreholes with any arbitrary orientation. In addition, a new tool, called Rock Strength Borehole Probe (RSBP), was developed for estimation of the rock strength through scratching the rock surface in the borehole. This device is designed to be a light, flexible, quick, non-disruptive, and cost effective alternative to estimate the rock strength inside the boreholes in underground mines and tunnels. An extensive number of laboratory tests under variable conditions were conducted to develop equations to estimate the Uniaxial Compressive Strength (UCS) and Brazilian Tensile Strength (BTS) of the rock from measured cutting forces. In these experiments, 27 different rock types were tested by full scale scratch tests, including the cutting tests by a miniature disc. The results show a good correlation between the normal force and the compressive strength of sedimentary/metamorphic rock if the depth of scratch is known. No significant correlation was observed for igneous rocks, due to the impacts of grain size. Current studies show promising results for using RSBP. The laboratory and field tests proved the functionality of this tool. This probe is capable of entering boreholes of 45 mm

  19. Frequency-Domain Tomography for Single-shot, Ultrafast Imaging of Evolving Laser-Plasma Accelerators

    NASA Astrophysics Data System (ADS)

    Li, Zhengyan; Zgadzaj, Rafal; Wang, Xiaoming; Downer, Michael

    2011-10-01

    Intense laser pulses propagating through plasma create plasma wakefields that often evolve significantly, e.g. by expanding and contracting. However, such dynamics are known in detail only through intensive simulations. Laboratory visualization of evolving plasma wakes in the ``bubble'' regime is important for optimizing and scaling laser-plasma accelerators. Recently snap-shots of quasi-static wakes were recorded using frequency-domain holography (FDH). To visualize the wake's evolution, we have generalized FDH to frequency-domain tomography (FDT), which uses multiple probes propagating at different angles with respect to the pump pulse. Each probe records a phase streak, imprinting a partial record of the evolution of pump-created structures. We then topographically reconstruct the full evolution from all phase streaks. To prove the concept, a prototype experiment visualizing nonlinear index evolution in glass is demonstrated. Four probes propagating at 0, 0.6, 2, 14 degrees to the index ``bubble'' are angularly and temporally multiplexed to a single spectrometer to achieve cost-effective FDT. From these four phase streaks, an FDT algorithm analogous to conventional CT yields a single-shot movie of the pump's self-focusing dynamics.

  20. Study the friction behaviour of poly[2-(dimethylamino)ethyl methacrylate] brush with AFM probes in contact mechanics

    NASA Astrophysics Data System (ADS)

    Raftari, Maryam; Zhang, Zhenyu; Leggett, Graham J.; Geoghegan, Mark

    2011-10-01

    We have studied the frictional behaviour of grafted poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) films using friction force microscopy (FFM). The films were prepared on native oxide-terminated silicon substrates using the technique of atom transfer radical polymerization (ATRP). We show that single asperity contact mechanics (Johnson-Kendall-Roberts(JKR) and Derjaguin-Muller-Toporov(DMT)) as well as a linear (Amontons) relation between applied load and frictional load depending on the pH of the FFM probe. Measurements were made using functionalized and unfunctionalized silicon nitride triangular probes. Functionalized probes included gold-coated probes, and ones coated with a self-assembled monolayer of dodecanethiol (DDT). The frictional behaviour between PDMAEMA and all tips immersed in pH from 3 to 11 are corresponded to the DMT or JKR model and are linear in pH=1, 2, and 12. These results show that contact mechanics of polyelectrolytes in water is complex and strongly dependent on the environmental pH.

  1. Coupling and decoupling of the accelerating units for pulsed synchronous linear accelerator

    NASA Astrophysics Data System (ADS)

    Shen, Yi; Liu, Yi; Ye, Mao; Zhang, Huang; Wang, Wei; Xia, Liansheng; Wang, Zhiwen; Yang, Chao; Shi, Jinshui; Zhang, Linwen; Deng, Jianjun

    2017-12-01

    A pulsed synchronous linear accelerator (PSLA), based on the solid-state pulse forming line, photoconductive semiconductor switch, and high gradient insulator technologies, is a novel linear accelerator. During the prototype PSLA commissioning, the energy gain of proton beams was found to be much lower than expected. In this paper, the degradation of the energy gain is explained by the circuit and cavity coupling effect of the accelerating units. The coupling effects of accelerating units are studied, and the circuit topologies of these two kinds of coupling effects are presented. Two methods utilizing inductance and membrane isolations, respectively, are proposed to reduce the circuit coupling effects. The effectiveness of the membrane isolation method is also supported by simulations. The decoupling efficiency of the metal drift tube is also researched. We carried out the experiments on circuit decoupling of the multiple accelerating cavity. The result shows that both circuit decoupling methods could increase the normalized voltage.

  2. Covariant Uniform Acceleration

    NASA Astrophysics Data System (ADS)

    Friedman, Yaakov; Scarr, Tzvi

    2013-04-01

    We derive a 4D covariant Relativistic Dynamics Equation. This equation canonically extends the 3D relativistic dynamics equation , where F is the 3D force and p = m0γv is the 3D relativistic momentum. The standard 4D equation is only partially covariant. To achieve full Lorentz covariance, we replace the four-force F by a rank 2 antisymmetric tensor acting on the four-velocity. By taking this tensor to be constant, we obtain a covariant definition of uniformly accelerated motion. This solves a problem of Einstein and Planck. We compute explicit solutions for uniformly accelerated motion. The solutions are divided into four Lorentz-invariant types: null, linear, rotational, and general. For null acceleration, the worldline is cubic in the time. Linear acceleration covariantly extends 1D hyperbolic motion, while rotational acceleration covariantly extends pure rotational motion. We use Generalized Fermi-Walker transport to construct a uniformly accelerated family of inertial frames which are instantaneously comoving to a uniformly accelerated observer. We explain the connection between our approach and that of Mashhoon. We show that our solutions of uniformly accelerated motion have constant acceleration in the comoving frame. Assuming the Weak Hypothesis of Locality, we obtain local spacetime transformations from a uniformly accelerated frame K' to an inertial frame K. The spacetime transformations between two uniformly accelerated frames with the same acceleration are Lorentz. We compute the metric at an arbitrary point of a uniformly accelerated frame. We obtain velocity and acceleration transformations from a uniformly accelerated system K' to an inertial frame K. We introduce the 4D velocity, an adaptation of Horwitz and Piron s notion of "off-shell." We derive the general formula for the time dilation between accelerated clocks. We obtain a formula for the angular velocity of a uniformly accelerated object. Every rest point of K' is uniformly accelerated, and

  3. Long-life mission reliability for outer planet atmospheric entry probes

    NASA Technical Reports Server (NTRS)

    Mccall, M. T.; Rouch, L.; Maycock, J. N.

    1976-01-01

    The results of a literature analysis on the effects of prolonged exposure to deep space environment on the properties of outer planet atmospheric entry probe components are presented. Materials considered included elastomers and plastics, pyrotechnic devices, thermal control components, metal springs and electronic components. The rates of degradation of each component were determined and extrapolation techniques were used to predict the effects of exposure for up to eight years to deep space. Pyrotechnic devices were aged under accelerated conditions to an equivalent of eight years in space and functionally tested. Results of the literature analysis of the selected components and testing of the devices indicated that no severe degradation should be expected during an eight year space mission.

  4. Analyzing radial acceleration with a smartphone acceleration sensor

    NASA Astrophysics Data System (ADS)

    Vogt, Patrik; Kuhn, Jochen

    2013-03-01

    This paper continues the sequence of experiments using the acceleration sensor of smartphones (for description of the function and the use of the acceleration sensor, see Ref. 1) within this column, in this case for analyzing the radial acceleration.

  5. Sandwich hybridization probes for the detection of Pseudo-nitzschia (Bacillariophyceae) species: An update to existing probes and a description of new probes.

    PubMed

    Bowers, Holly A; Marin, Roman; Birch, James M; Scholin, Christopher A

    2017-12-01

    New sandwich hybridization assay (SHA) probes for detecting Pseudo-nitzschia species (P. arenysensis, P. fraudulenta, P. hasleana, P. pungens) are presented, along with updated cross-reactivity information on historical probes (SHA and FISH; fluorescence in situ hybridization) targeting P. australis and P. multiseries. Pseudo-nitzschia species are a cosmopolitan group of diatoms that produce varying levels of domoic acid (DA), a neurotoxin that can accumulate in finfish and shellfish and transfer throughout the food web. Consumption of infected food sources can lead to illness in humans (amnesic shellfish poisoning; ASP) and marine wildlife (domoic acid poisoning; DAP). The threat of human illness, along with economic loss from fishery closures has resulted in the implementation of monitoring protocols and intensive ecological studies. SHA probes have been instrumental in some of these efforts, as the technique performs well in complex heterogeneous sample matrices and has been adapted to benchtop and deployable (Environmental Sample Processor) platforms. The expanded probe set will enhance future efforts towards understanding spatial, temporal and successional patterns in species during bloom and non-bloom periods. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Influence of probe geometry on pitot-probe displacement in supersonic turbulent flow

    NASA Technical Reports Server (NTRS)

    Allen, J. M.

    1975-01-01

    An experiment was conducted to determine the varying effects of six different probe-tip and support-shaft configurations on pitot tube displacement. The study was stimulated by discrepancies between supersonic wind-tunnel tests conducted by Wilson and Young (1949) and Allen (1972). Wilson (1973) had concluded that these discrepancies were caused by differences in probe geometry. It is shown that in fact, no major differences in profiles of streamwise velocity over streamwise velocity at boundary-layer edge vs normal coordinate over boundary-layer total thickness result from geometry. The true cause of the discrepancies, however, remains to be discovered.

  7. Report on accelerated corrosion studies.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mowry, Curtis Dale; Glass, Sarah Jill; Sorensen, Neil Robert

    2011-03-01

    Sandia National Laboratories (SNL) conducted accelerated atmospheric corrosion testing for the U.S. Consumer Product Safety Commission (CPSC) to help further the understanding of the development of corrosion products on conductor materials in household electrical components exposed to environmental conditions representative of homes constructed with problem drywall. The conditions of the accelerated testing were chosen to produce corrosion product growth that would be consistent with long-term exposure to environments containing humidity and parts per billion (ppb) levels of hydrogen sulfide (H{sub 2}S) that are thought to have been the source of corrosion in electrical components from affected homes. This report documentsmore » the test set-up, monitoring of electrical performance of powered electrical components during the exposure, and the materials characterization conducted on wires, screws, and contact plates from selected electrical components. No degradation in electrical performance (measured via voltage drop) was measured during the course of the 8-week exposure, which was approximately equivalent to 40 years of exposure in a light industrial environment. Analyses show that corrosion products consisting of various phases of copper sulfide, copper sulfate, and copper oxide are found on exposed surfaces of the conductor materials including wires, screws, and contact plates. The morphology and the thickness of the corrosion products showed a range of character. In some of the copper wires that were observed, corrosion product had flaked or spalled off the surface, exposing fresh metal to the reaction with the contaminant gasses; however, there was no significant change in the wire cross-sectional area.« less

  8. Intrinsic Fluorescence as a Spectral Probe for Protein Denaturation Studies in the Presence of Honey

    NASA Astrophysics Data System (ADS)

    Wong, Y. H.; Kadir, H. A.; Tayyab, S.

    2015-11-01

    Honey was found to quench the intrinsic fluorescence of bovine serum albumin (BSA) in a concentration dependent manner, showing complete quenching in the presence of 5% (w/v) honey. Increasing the protein concentration up to 5.0 μM did not lead to the recovery of the protein fluorescence. Urea denaturation of BSA, which otherwise shows a two-step, three-state transition, using intrinsic fluorescence of the protein as the probe failed to produce any result in the presence of 5% (w/v) honey. Thus, intrinsic fluorescence cannot be used as a spectral probe for protein denaturation studies in the presence of honey.

  9. Propagation of Dipolarization Signatures Observed by the Van Allen Probes in the Inner Magnetosphere

    NASA Astrophysics Data System (ADS)

    Ohtani, S.; Motoba, T.; Gkioulidou, M.; Takahashi, K.; Kletzing, C.

    2017-12-01

    Dipolarization, the change of the local magnetic field from a stretched to a more dipolar configuration, is one of the most fundamental processes of magnetospheric physics. It is especially critical for the dynamics of the inner magnetosphere. The associated electric field accelerates ions and electrons and transports them closer to Earth. Such injected ions intensify the ring current, and electrons constitute the seed population of the radiation belt. Those ions and electrons may also excite various waves that play important roles in the enhancement and loss of the radiation belt electrons. Despite such critical consequences, the general characteristics of dipolarization in the inner magnetosphere still remain to be understood. The Van Allen Probes mission, which consists of two probes that orbit through the equatorial region of the inner magnetosphere, provides an ideal opportunity to examine dipolarization signatures in the core of the ring current. In the present study we investigate the spatial expansion of the dipolarization region by examining the correlation and time delay of dipolarization signatures observed by the two probes. Whereas in general it requires three-point measurements to deduce the propagation of a signal on a certain plane, we statically examined the observed time delays and found that dipolarization signatures tend to propagate radially inward as well as away from midnight. In this paper we address the propagation of dipolarization signatures quantitatively and compare with the propagation velocities reported previously based on observations made farther away from Earth. We also discuss how often and under what conditions the dipolarization region expands.

  10. Accelerator Science: Proton vs. Electron

    ScienceCinema

    Lincoln, Don

    2018-06-12

    Particle accelerators are one of the most powerful ways to study the fundamental laws that govern the universe. However, there are many design considerations that go into selecting and building a particular accelerator. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of building an accelerator that collides pairs of protons to one that collides electrons.

  11. Accelerator Science: Proton vs. Electron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lincoln, Don

    Particle accelerators are one of the most powerful ways to study the fundamental laws that govern the universe. However, there are many design considerations that go into selecting and building a particular accelerator. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of building an accelerator that collides pairs of protons to one that collides electrons.

  12. Ultra-compact swept-source optical coherence tomography handheld probe with motorized focus adjustment (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    LaRocca, Francesco; Nankivil, Derek; Keller, Brenton; Farsiu, Sina; Izatt, Joseph A.

    2017-02-01

    Handheld optical coherence tomography (OCT) systems facilitate imaging of young children, bedridden subjects, and those with less stable fixation. Smaller and lighter OCT probes allow for more efficient imaging and reduced operator fatigue, which is critical for prolonged use in either the operating room or neonatal intensive care unit. In addition to size and weight, the imaging speed, image quality, field of view, resolution, and focus correction capability are critical parameters that determine the clinical utility of a handheld probe. Here, we describe an ultra-compact swept source (SS) OCT handheld probe weighing only 211 g (half the weight of the next lightest handheld SSOCT probe in the literature) with 20.1 µm lateral resolution, 7 µm axial resolution, 102 dB peak sensitivity, a 27° x 23° field of view, and motorized focus adjustment for refraction correction between -10 to +16 D. A 2D microelectromechanical systems (MEMS) scanner, a converging beam-at-scanner telescope configuration, and an optical design employing 6 different custom optics were used to minimize device size and weight while achieving diffraction limited performance throughout the system's field of view. Custom graphics processing unit (GPU)-accelerated software was used to provide real-time display of OCT B-scans and volumes. Retinal images were acquired from adult volunteers to demonstrate imaging performance.

  13. Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spentzouris, P.; /Fermilab; Cary, J.

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessarymore » accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The Com

  14. Study of protein-probe interaction and protective action of surfactant sodium dodecyl sulphate in urea-denatured HSA using charge transfer fluorescence probe methyl ester of N,N-dimethylamino naphthyl acrylic acid.

    PubMed

    Mahanta, Subrata; Singh, Rupashree Balia; Guchhait, Nikhil

    2009-03-01

    We have demonstrated that the intramolecular charge transfer (ICT) probe Methyl ester of N,N-dimethylamino naphthyl acrylic acid (MDMANA) serves as an efficient reporter of the proteinous microenvironment of Human Serum Albumin (HSA). This work reports the binding phenomenon of MDMANA with HSA and spectral modulation thereupon. The extent of binding and free energy change for complexation reaction along with efficient fluorescence resonance energy transfer from Trp-214 of HSA to MDMANA indicates strong binding between probe and protein. Fluorescence anisotropy, red edge excitation shift, acrylamide quenching and time resolved measurements corroborate the binding nature of the probe with protein and predicts that the probe molecule is located at the hydrophobic site of the protein HSA. Due to the strong binding ability of MDMANA with HSA, it is successfully utilized for the study of stabilizing action of anionic surfactant Sodium Dodecyl Sulphate to the unfolding and folding of protein with denaturant urea in concentration range 1M to 9M.

  15. Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer.

    PubMed

    Lim, Sun Min; Chang, Hyun; Cha, Yoon Jin; Liang, Shile; Tai, Yan Chin; Li, Gu; Pestova, Ekaterina; Policht, Frank; Perez, Thomas; Soo, Ross A; Park, Won Young; Kim, Hye Ryun; Shim, Hyo Sup; Cho, Byoung Chul

    2017-09-01

    ALK and ROS1 gene rearrangements are distinct molecular subsets of non-small-cell lung cancer (NSCLC), and they are strong predictive biomarkers of response to ALK/ROS1 inhibitors, such as crizotinib. Thus, it is clinically important to develop an effective screening strategy to detect patients who will benefit from such treatment. In this study, we aimed to validate analytical performance of Vysis ALK/ROS1 Dual Break Apart Probe Kit (RUO) in NSCLC. Study population composed of three patient cohorts with histologically confirmed lung adenocarcinoma (patients with ALK rearrangement, patients with ROS1 rearrangement and patients with wild-type ALK and ROS1). Specimens consisted of 12 ALK-positive, 8 ROS1-positive and 21 ALK/ROS1-wild type formalin-fixed paraffin-embedded samples obtained from surgical resection or excisional biopsy. ALK rearrangement was previously assessed by Vysis ALK Break Apart FISH Probe Kit (Abbott Molecular, Abbot Park, IL, USA) and ROS1 rearrangement was previously assessed by ZytoLight ® SPEC ROS1 Break Apart Probe (ZytoVision, GmbH). All specimens were re-evaluated by Vysis ALK/ROS1 Dual Break Apart Probe Kit. FISH images were scanned on BioView AllegroPlus system and interpreted via BioView SoloWeb remotely. For a total of 41 patient samples, the concordance of the results by Vysis ALK/ROS1 Dual Break Apart Probe Kit was evaluated and compared to the known ALK and ROS1 rearrangement status of the specimen. Of the 12 ALK-positive cases, hybridization with Vysis ALK/ROS1 Dual Break Apart Probe Kit was successful in 10 cases (success rate 10/12, 83%) and of these 10 cases, all showed ALK rearrangement (100% concordance with the results of Vysis ALK Break Apart FISH Probe Kit). Two of the ALK+ cases were excluded due to weak ROS1 signals that could not be enumerated. Of the 8 ROS1-positive cases, 6 cases were successfully evaluated using Vysis ALK/ROS1 Dual Break Apart Probe Kit. The success rate was 75% (6/8), and of these 6 cases, all

  16. Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness

    NASA Astrophysics Data System (ADS)

    Labate, Luca; Andreassi, Maria Grazia; Baffigi, Federica; Basta, Giuseppina; Bizzarri, Ranieri; Borghini, Andrea; Candiano, Giuliana C.; Casarino, Carlo; Cresci, Monica; Di Martino, Fabio; Fulgentini, Lorenzo; Ghetti, Francesco; Gilardi, Maria Carla; Giulietti, Antonio; Köster, Petra; Lenci, Francesco; Levato, Tadzio; Oishi, Yuji; Russo, Giorgio; Sgarbossa, Antonella; Traino, Claudio; Gizzi, Leonida A.

    2013-05-01

    Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.

  17. High Gradient Accelerator Research

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Temkin, Richard

    The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave coldmore » test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.« less

  18. Theory of unfolded cyclotron accelerator

    NASA Astrophysics Data System (ADS)

    Rax, J.-M.; Robiche, J.

    2010-10-01

    An acceleration process based on the interaction between an ion, a tapered periodic magnetic structure, and a circularly polarized oscillating electric field is identified and analyzed, and its potential is evaluated. A Hamiltonian analysis is developed in order to describe the interplay between the cyclotron motion, the electric acceleration, and the magnetic modulation. The parameters of this universal class of magnetic modulation leading to continuous acceleration without Larmor radius increase are expressed analytically. Thus, this study provides the basic scaling of what appears as a compact unfolded cyclotron accelerator.

  19. Accelerated optical polymer aging studies for LED luminaire applications

    NASA Astrophysics Data System (ADS)

    Estupiñán, Edgar; Wendling, Peter; Kostrun, Marijan; Garner, Richard

    2013-09-01

    There is a need in the lighting industry to design and implement accelerated aging methods that accurately simulate the aging process of LED luminaire components. In response to this need, we have built a flexible and reliable system to study the aging characteristics of optical polymer materials, and we have employed it to study a commercially available LED luminaire diffuser made of PMMA. The experimental system consists of a "Blue LED Emitter" and a working surface. Both the temperatures of the samples and the optical powers of the LEDs are appropriately characterized in the system. Several accelerated aging experiments are carried out at different temperatures and optical powers over a 90 hour period and the measured transmission values are used as inputs to a degradation model derived using plausibility arguments. This model seems capable of predicting the behavior of the material as a function of time, temperature and optical power. The model satisfactorily predicts the measured transmission values of diffusers aged in luminaires at two different times and thus can be used to make application recommendations for this material. Specifically, at 35000 hours (the manufacturer's stated life of the luminaire) and at the typical operational temperature of the diffuser, the model predicts a transmission loss of only a few percent over the original transmission of the material at 450 nm, which renders this material suitable for this application.

  20. Laser-heated emissive plasma probe.

    PubMed

    Schrittwieser, Roman; Ionita, Codrina; Balan, Petru; Gstrein, Ramona; Grulke, Olaf; Windisch, Thomas; Brandt, Christian; Klinger, Thomas; Madani, Ramin; Amarandei, George; Sarma, Arun K

    2008-08-01

    Emissive probes are standard tools in laboratory plasmas for the direct determination of the plasma potential. Usually they consist of a loop of refractory wire heated by an electric current until sufficient electron emission. Recently emissive probes were used also for measuring the radial fluctuation-induced particle flux and other essential parameters of edge turbulence in magnetized toroidal hot plasmas [R. Schrittwieser et al., Plasma Phys. Controlled Fusion 50, 055004 (2008)]. We have developed and investigated various types of emissive probes, which were heated by a focused infrared laser beam. Such a probe has several advantages: higher probe temperature without evaporation or melting and thus higher emissivity and longer lifetime, no deformation of the probe in a magnetic field, no potential drop along the probe wire, and faster time response. The probes are heated by an infrared diode laser with 808 nm wavelength and an output power up to 50 W. One probe was mounted together with the lens system on a radially movable probe shaft, and radial profiles of the plasma potential and of its oscillations were measured in a linear helicon discharge.

  1. Ballistocardiogaphic studies with acceleration and electromechanical film sensors.

    PubMed

    Alametsä, J; Värri, A; Viik, J; Hyttinen, J; Palomäki, A

    2009-11-01

    The purpose of this research is to demonstrate and compare the utilization of electromechanical film (EMFi) and two acceleration sensors, ADXL202 and MXA2500U, for ballistocardiographic (BCG) and pulse transit time (PTT) studies. We have constructed a mobile physiological measurement station including amplifiers and a data collection system to record the previously mentioned signals and an electrocardiogram signal. Various versions of the measuring systems used in BCG studies in the past are also presented and evaluated. We have showed the ability of the EMFi sensor to define the elastic properties of the cardiovascular system and to ensure the functionality of the proposed instrumentation in different physiological loading conditions, before and after exercise and sauna bath. The EMFi sensor provided a BCG signal of good quality in the study of the human heart and function of the cardiovascular system with different measurement configurations. EMFi BCG measurements provided accurate and repeatable results for the different components of the heart cycle. In multiple-channel EMFi measurements, the carotid and limb pulse signals acquired were detailed and distinctive, allowing accurate PTT measurements. Changes in blood pressure were clearly observed and easily determined with EMFi sensor strips in pulse wave velocity (PWV) measurements. In conclusion, the configuration of the constructed device provided reliable measurements of the electrocardiogram, BCG, heart sound, and carotid and ankle pulse wave signals. Attached EMFi sensor strips on the neck and limbs yield completely new applications of the EMFi sensors aside from the conventional seat and supine recordings. Higher sensitivity, ease of utilization, and minimum discomfort of the EMFi sensor compared with acceleration sensors strengthen the status of the EMFi sensor for accurate and reliable BCG and PWV measurements, providing novel evaluation of the elastic properties of the cardiovascular system.

  2. Multispectral Phloem-Mobile Probes: Properties and Applications1

    PubMed Central

    Knoblauch, Michael; Vendrell, Marc; de Leau, Erica; Paterlini, Andrea; Knox, Kirsten; Ross-Elliot, Tim; Reinders, Anke; Brockman, Stephen A.; Ward, John; Oparka, Karl

    2015-01-01

    Using Arabidopsis (Arabidopsis thaliana) seedlings, we identified a range of small fluorescent probes that entered the translocation stream and were unloaded at the root tip. These probes had absorbance/emission maxima ranging from 367/454 to 546/576 nm and represent a versatile toolbox for studying phloem transport. Of the probes that we tested, naturally occurring fluorescent coumarin glucosides (esculin and fraxin) were phloem loaded and transported in oocytes by the sucrose transporter, AtSUC2. Arabidopsis plants in which AtSUC2 was replaced with barley (Hordeum vulgare) sucrose transporter (HvSUT1), which does not transport esculin in oocytes, failed to load esculin into the phloem. In wild-type plants, the fluorescence of esculin decayed to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labeling studies of phloem transport. We identified additional probes, such as carboxytetraethylrhodamine, a red fluorescent probe that, unlike esculin, was stable for several hours after phloem unloading and could be used to study phloem transport in Arabidopsis lines expressing green fluorescent protein. PMID:25653316

  3. Molecular inversion probe assay.

    PubMed

    Absalan, Farnaz; Ronaghi, Mostafa

    2007-01-01

    We have described molecular inversion probe technologies for large-scale genetic analyses. This technique provides a comprehensive and powerful tool for the analysis of genetic variation and enables affordable, large-scale studies that will help uncover the genetic basis of complex disease and explain the individual variation in response to therapeutics. Major applications of the molecular inversion probes (MIP) technologies include targeted genotyping from focused regions to whole-genome studies, and allele quantification of genomic rearrangements. The MIP technology (used in the HapMap project) provides an efficient, scalable, and affordable way to score polymorphisms in case/control populations for genetic studies. The MIP technology provides the highest commercially available multiplexing levels and assay conversion rates for targeted genotyping. This enables more informative, genome-wide studies with either the functional (direct detection) approach or the indirect detection approach.

  4. SU-E-J-205: Monte Carlo Modeling of Ultrasound Probes for Real-Time Ultrasound Image-Guided Radiotherapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hristov, D; Schlosser, J; Bazalova, M

    2014-06-01

    Purpose: To quantify the effect of ultrasound (US) probe beam attenuation for radiation therapy delivered under real-time US image guidance by means of Monte Carlo (MC) simulations. Methods: MC models of two Philips US probes, an X6-1 matrix-array transducer and a C5-2 curved-array transducer, were built based on their CT images in the EGSnrc BEAMnrc and DOSXYZnrc codes. Due to the metal parts, the probes were scanned in a Tomotherapy machine with a 3.5 MV beam. Mass densities in the probes were assigned based on an electron density calibration phantom consisting of cylinders with mass densities between 0.2–8.0 g/cm{sup 3}.more » Beam attenuation due to the probes was measured in a solid water phantom for a 6 MV and 15 MV 15x15 cm{sup 2} beam delivered on a Varian Trilogy linear accelerator. The dose was measured with the PTW-729 ionization chamber array at two depths and compared to MC simulations. The extreme case beam attenuation expected in robotic US image guided radiotherapy for probes in upright position was quantified by means of MC simulations. Results: The 3.5 MV CT number to mass density calibration curve was found to be linear with R{sup 2} > 0.99. The maximum mass densities were 4.6 and 4.2 g/cm{sup 3} in the C5-2 and X6-1 probe, respectively. Gamma analysis of the simulated and measured doses revealed that over 98% of measurement points passed the 3%/3mm criteria for both probes and measurement depths. The extreme attenuation for probes in upright position was found to be 25% and 31% for the C5-2 and X6-1 probe, respectively, for both 6 and 15 MV beams at 10 cm depth. Conclusion: MC models of two US probes used for real-time image guidance during radiotherapy have been built. As a Result, radiotherapy treatment planning with the imaging probes in place can now be performed. J Schlosser is an employee of SoniTrack Systems, Inc. D Hristov has financial interest in SoniTrack Systems, Inc.« less

  5. Particle acceleration in pulsar magnetospheres

    NASA Technical Reports Server (NTRS)

    Baker, K. B.

    1978-01-01

    The structure of pulsar magnetospheres and the acceleration mechanism for charged particles in the magnetosphere was studied using a pulsar model which required large acceleration of the particles near the surface of the star. A theorem was developed which showed that particle acceleration cannot be expected when the angle between the magnetic field lines and the rotation axis is constant (e.g. radial field lines). If this angle is not constant, however, acceleration must occur. The more realistic model of an axisymmetric neutron star with a strong dipole magnetic field aligned with the rotation axis was investigated. In this case, acceleration occurred at large distances from the surface of the star. The magnitude of the current can be determined using the model presented. In the case of nonaxisymmetric systems, the acceleration is expected to occur nearer to the surface of the star.

  6. Measurement of Transverse Wakefields Induced by a Misaligned Positron Bunch in a Hollow Channel Plasma Accelerator.

    PubMed

    Lindstrøm, C A; Adli, E; Allen, J M; An, W; Beekman, C; Clarke, C I; Clayton, C E; Corde, S; Doche, A; Frederico, J; Gessner, S J; Green, S Z; Hogan, M J; Joshi, C; Litos, M; Lu, W; Marsh, K A; Mori, W B; O'Shea, B D; Vafaei-Najafabadi, N; Yakimenko, V

    2018-03-23

    Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, and measured with another 20 GeV lower charge trailing positron probe bunch. The measurements are largely consistent with theory.

  7. Measurement of Transverse Wakefields Induced by a Misaligned Positron Bunch in a Hollow Channel Plasma Accelerator

    NASA Astrophysics Data System (ADS)

    Lindstrøm, C. A.; Adli, E.; Allen, J. M.; An, W.; Beekman, C.; Clarke, C. I.; Clayton, C. E.; Corde, S.; Doche, A.; Frederico, J.; Gessner, S. J.; Green, S. Z.; Hogan, M. J.; Joshi, C.; Litos, M.; Lu, W.; Marsh, K. A.; Mori, W. B.; O'Shea, B. D.; Vafaei-Najafabadi, N.; Yakimenko, V.

    2018-03-01

    Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, and measured with another 20 GeV lower charge trailing positron probe bunch. The measurements are largely consistent with theory.

  8. Accelerators, Beams And Physical Review Special Topics - Accelerators And Beams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siemann, R.H.; /SLAC

    Accelerator science and technology have evolved as accelerators became larger and important to a broad range of science. Physical Review Special Topics - Accelerators and Beams was established to serve the accelerator community as a timely, widely circulated, international journal covering the full breadth of accelerators and beams. The history of the journal and the innovations associated with it are reviewed.

  9. Commnity Petascale Project for Accelerator Science And Simulation: Advancing Computational Science for Future Accelerators And Accelerator Technologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spentzouris, Panagiotis; /Fermilab; Cary, John

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessarymore » accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.« less

  10. Observational Study of Particle Acceleration in the 2006 December 13 Flare

    NASA Astrophysics Data System (ADS)

    Minoshima, T.; Morimoto, T.; Kawate, T.; Imada, S.; Koshiishi, H.; Masuda, S.; Kubo, M.; Inoue, S.; Isobe, H.; Krucker, S.; Yokoyama, T.

    2008-12-01

    We study the particle acceleration in a flare on 2006 December 13, by using the Hinode, RHESSI, Nobeyama Radio Polarimeters (NoRP) and Nobeyama Radioheliograph (NoRH) observations. For technical reasons, both RHESSI and NoRH have a problem in imaging in this flare. Since we have succeeded in solving the problem, it is now possible to discuss the particle acceleration mechanism from an image analysis. This flare shows very long-lasting (1 hour) non-thermal emissions, consisting of many spikes. We focus on the second major spike at 02:29 UT, because the RHESSI image is available only in this period. The RHESSI 35-100 keV HXR image shows double sources located at the footpoints of the western soft X-ray (SXR) loop seen by the Hinode/XRT. The non-linear force-free (NLFF) modeling based on a magnetogram data by Inoue et al. shows the NLFF to potential magnetic transition of the loop, which would induce the electric field and then accelerate particles. Overlaying the HXR image on the photospheric three-dimensional magnetic field map taken by the Hinode Spectro-Polarimeter, we find that the HXR sources are located at the region where the horizontal magnetic fields invert. The NoRH 34 GHz microwave images show the loop structure connecting the HXR sources. The microwave peaks do not located at the top of the loop but between the loop top and the footpoints. The NoRP microwave spectrum shows the soft-hard-soft pattern in the period, same as the HXR spectrum (Ning 2008). From these observational results we suggest that the electrons were accelerated parallel to the magnetic field line near the magnetic separatrix.

  11. Innovative SPM Probes for Energy-Storage Science: MWCNT-Nanopipettes to Nanobattery Probes

    NASA Astrophysics Data System (ADS)

    Larson, Jonathan; Talin, Alec; Pearse, Alexander; Kozen, Alexander; Reutt-Robey, Janice

    As energy-storage materials and designs continue to advance, new tools are needed to direct and explore ion insertion/de-insertion at well-defined battery materials interfaces. Scanned probe tips, assembled from actual energy-storage materials, permit SPM measures of local cathode-anode (tip-sample) interactions, including ion transfer. We present examples of ``cathode'' MWCNT-terminated STM probe tips interacting with Li(s)/Si(111) anode substrates. The MWCNT tip functions as both SPM probe and Li-nanopipette,[1] for controlled transport and manipulation of Li. Local field conditions for lithium ionization and transfer are determined and compared to electrostatic models. Additional lithium metallic and oxide tips have been prepared by thin film deposition on conventional W tips, the latter of which effectively functions as a nanobattery. We demonstrate use of these novel probe materials in the local lithiation of low-index Si anode interfaces, probing local barriers for lithium insertion. Prospects and limitations of these novel SPM probes will be discussed. U.S. Department of Energy Award Number DESC0001160.

  12. Development of Mackintosh Probe Extractor

    NASA Astrophysics Data System (ADS)

    Rahman, Noor Khazanah A.; Kaamin, Masiri; Suwandi, Amir Khan; Sahat, Suhaila; Jahaya Kesot, Mohd

    2016-11-01

    Dynamic probing is a continuous soil investigation technique, which is one of the simplest soil penetration test. It basically consist of repeatedly driving a metal tipped probe into the ground using a drop weight of fixed mass and travel. Testing was carried out continuously from ground level to the final penetration depth. Once the soil investigation work done, it is difficult to pull out the probe rod from the ground, due to strong soil structure grip against probe cone and prevent the probe rod out from the ground. Thus, in this case, a tool named Extracting Probe was created to assist in the process of retracting the probe rod from the ground. In addition, Extracting Probe also can reduce the time to extract the probe rod from the ground compare with the conventional method. At the same time, it also can reduce manpower cost because only one worker involve to handle this tool compare with conventional method used two or more workers. From experiment that have been done we found that the time difference between conventional tools and extracting probe is significant, average time difference is 155 minutes. In addition the extracting probe can reduce manpower usage, and also labour cost for operating the tool. With all these advantages makes this tool has the potential to be marketed.

  13. Standard deviations of composition measurements in atom probe analyses. Part I conventional 1D atom probe.

    PubMed

    Danoix, F; Grancher, G; Bostel, A; Blavette, D

    2007-09-01

    Atom probe is a very powerful instrument to measure concentrations on a sub nanometric scale [M.K. Miller, G.D.W. Smith, Atom Probe Microanalysis, Principles and Applications to Materials Problems, Materials Research Society, Pittsburgh, 1989]. Atom probe is therefore a unique tool to study and characterise finely decomposed metallic materials. Composition profiles or 3D mapping can be realised by gathering elemental composition measurements. As the detector efficiency is generally not equal to 1, the measured compositions are only estimates of actual values. The variance of the estimates depends on which information is to be estimated. It can be calculated when the detection process is known. These two papers are devoted to give complete analytical derivation and expressions of the variance on composition measurements in several situations encountered when using atom probe. In the first paper, we will concentrate on the analytical derivation of the variance when estimation of compositions obtained from a conventional one dimension (1D) atom probe is considered. In particular, the existing expressions, and the basic hypotheses on which they rely, will be reconsidered, and complete analytical demonstrations established. In the second companion paper, the case of 3D atom probe will be treated, highlighting how the knowledge of the 3D position of detected ions modifies the analytical derivation of the variance of local composition data.

  14. Quasars in miniature: new insights into particle acceleration from X-ray binaries

    NASA Astrophysics Data System (ADS)

    Markoff, Sera

    2013-04-01

    A variety of astronomical objects routinely accelerate particles to high energy, with the maximum possible energy per particle typically limited by the size of the system and magnetic field strength. For that reason, much attention has focused on the massive jets of relativistic plasma ejected from supermassive black holes in Active Galactic Nuclei (AGN), which are at least theoretically capable of producing particles (cosmic rays) up to a whopping 10{20 }eV. However neither how these jets are formed or function, nor how exactly they accelerate particles, is well understood. While we do not expect the mechanisms for particle acceleration in stellar remnant black holes within X-ray binaries (XRBs) to be particularly different than in other sources, XRBs do offer some unique insights. Primarily, jets very similar to those in AGN come and go on timescales of weeks to months, while often monitored simultaneously across the entire electromagnetic spectrum. Through such observations we have been able to probe the processes by which jets not only build up dynamically, but also at what point the jets begin to accelerate particles, providing hints about the necessary conditions and efficiencies. Because the physics of accretion-driven processes such as jets seems to scale predictably with black hole mass, we can also potentially apply what we are learning in these smaller systems to the same phenomena AGN, giving us a new handle on several longstanding questions. I will review our current understanding of particle acceleration in XRBs, as well as the increasing body of evidence suggesting that XRBs indeed seem to represent scaled-down (and thus handily faster evolving) versions of the much more powerful AGN. I will also touch on how accelerated particles from XRBs may contribute significantly to the low-energy Galactic cosmic ray distribution, with local impact on gas chemistry and star formation.

  15. Reproducibility of the cutoff probe for the measurement of electron density

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, D. W.; Oh, W. Y.; You, S. J., E-mail: sjyou@cnu.ac.kr

    2016-06-15

    Since a plasma processing control based on plasma diagnostics attracted considerable attention in industry, the reproducibility of the diagnostics using in this application has become a great interest. Because the cutoff probe is one of the potential candidates for this application, knowing the reproducibility of the cutoff probe measurement becomes quit important in the cutoff probe application research. To test the reproducibility of the cutoff probe measurement, in this paper, a comparative study among the different cutoff probe measurements was performed. The comparative study revealed remarkable result: the cutoff probe has a great reproducibility for the electron density measurement, i.e.,more » there are little differences among measurements by different probes made by different experimenters. The discussion including the reason for the result was addressed via this paper by using a basic measurement principle of cutoff probe and a comparative experiment with Langmuir probe.« less

  16. Variable path length spectrophotometric probe

    DOEpatents

    O'Rourke, Patrick E.; McCarty, Jerry E.; Haggard, Ricky A.

    1992-01-01

    A compact, variable pathlength, fiber optic probe for spectrophotometric measurements of fluids in situ. The probe comprises a probe body with a shaft having a polished end penetrating one side of the probe, a pair of optic fibers, parallel and coterminous, entering the probe opposite the reflecting shaft, and a collimating lens to direct light from one of the fibers to the reflecting surface of the shaft and to direct the reflected light to the second optic fiber. The probe body has an inlet and an outlet port to allow the liquid to enter the probe body and pass between the lens and the reflecting surface of the shaft. A linear stepper motor is connected to the shaft to cause the shaft to advance toward or away from the lens in increments so that absorption measurements can be made at each of the incremental steps. The shaft is sealed to the probe body by a bellows seal to allow freedom of movement of the shaft and yet avoid leakage from the interior of the probe.

  17. Angular velocities, angular accelerations, and coriolis accelerations

    NASA Technical Reports Server (NTRS)

    Graybiel, A.

    1975-01-01

    Weightlessness, rotating environment, and mathematical analysis of Coriolis acceleration is described for man's biological effective force environments. Effects on the vestibular system are summarized, including the end organs, functional neurology, and input-output relations. Ground-based studies in preparation for space missions are examined, including functional tests, provocative tests, adaptive capacity tests, simulation studies, and antimotion sickness.

  18. Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study.

    PubMed

    Schnack, Hugo G; van Haren, Neeltje E M; Nieuwenhuis, Mireille; Hulshoff Pol, Hilleke E; Cahn, Wiepke; Kahn, René S

    2016-06-01

    Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used support vector regression, a supervised machine learning technique, to address this question. In a longitudinal sample of 341 schizophrenia patients and 386 healthy subjects with one or more structural MRI scans (1,197 in total), machine learning algorithms were used to build models to predict the age of the brain and the presence of schizophrenia ("schizophrenia score"), based on the gray matter density maps. Age at baseline ranged from 16 to 67 years, and follow-up scans were acquired between 1 and 13 years after the baseline scan. Differences between brain age and chronological age ("brain age gap") and between schizophrenia score and healthy reference score ("schizophrenia gap") were calculated. Accelerated brain aging was calculated from changes in brain age gap between two consecutive measurements. The age prediction model was validated in an independent sample. In schizophrenia patients, brain age was significantly greater than chronological age at baseline (+3.36 years) and progressively increased during follow-up (+1.24 years in addition to the baseline gap). The acceleration of brain aging was not constant: it decreased from 2.5 years/year just after illness onset to about the normal rate (1 year/year) approximately 5 years after illness onset. The schizophrenia gap also increased during follow-up, but more pronounced variability in brain abnormalities at follow-up rendered this increase nonsignificant. The progressive brain loss in schizophrenia appears to reflect two different processes: one relatively homogeneous, reflecting accelerated aging of the brain and related to various measures of outcome, and a more variable one, possibly reflecting individual variation and

  19. Rail accelerator research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Kerslake, W. R.; Cybyk, B. Z.

    1982-01-01

    A rail accelerator was chosen for study as an electromagnetic space propulsion device because of its simplicity and existing technology base. The results of a mission feasibility study using a large rail accelerator for direct launch of ton-size payloads from the Earth's surface to space, and the results of initial tests with a small, laboratory rail accelerator are presented. The laboratory rail accelerator has a bore of 3 by 3 mm and has accelerated 60 mg projectiles to velocities of 300 to 1000 m/s. Rail materials of Cu, W, and Mo were tested for efficiency and erosion rate.

  20. Fermilab | Tevatron | Accelerator

    Science.gov Websites

    Leading accelerator technology Accelerator complex Illinois Accelerator Research Center Fermilab temperature. They were used to transfer particles from one part of the Fermilab accelerator complex to another center ring of Fermilab's accelerator complex. Before the Tevatron shut down, it had three primary

  1. Experimental Validation of a Branched Solution Model for Magnetosonic Ionization Waves in Plasma Accelerators

    NASA Astrophysics Data System (ADS)

    Underwood, Thomas; Loebner, Keith; Cappelli, Mark

    2015-11-01

    Detailed measurements of the thermodynamic and electrodynamic plasma state variables within the plume of a pulsed plasma accelerator are presented. A quadruple Langmuir probe operating in current-saturation mode is used to obtain time resolved measurements of the plasma density, temperature, potential, and velocity along the central axis of the accelerator. This data is used in conjunction with a fast-framing, intensified CCD camera to develop and validate a model predicting the existence of two distinct types of ionization waves corresponding to the upper and lower solution branches of the Hugoniot curve. A deviation of less than 8% is observed between the quasi-steady, one-dimensional theoretical model and the experimentally measured plume velocity. This work is supported by the U.S. Department of Energy Stewardship Science Academic Program in addition to the National Defense Science Engineering Graduate Fellowship.

  2. Interrogating Protein Phosphatases with Chemical Activity Probes.

    PubMed

    Casey, Garrett R; Stains, Cliff I

    2018-06-04

    Protein phosphatases, while long overlooked, have recently become appreciated as drivers of both normal- and disease-associated signaling events. As a result, the spotlight is now turning torwards this enzyme family and efforts geared towards the development of modern chemical tools for studying these enzymes are well underway. This Minireview focuses on the evolution of chemical activity probes, both optical and covalent, for the study of protein phosphatases. Small-molecule probes, global monitoring of phosphatase activity through the use of covalent modifiers, and targeted fluorescence-based activity probes are discussed. We conclude with an overview of open questions in the field and highlight the potential impact of chemical tools for studying protein phosphatases. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Atom probe study of grain boundary segregation in technically pure molybdenum

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Babinsky, K., E-mail: katharina.babinsky@stud.unileoben.ac.at; Weidow, J., E-mail: jonathan.weidow@chalmers.se; Knabl, W., E-mail: wolfram.knabl@plansee.com

    2014-01-15

    Molybdenum, a metal with excellent physical, chemical and high-temperature properties, is an interesting material for applications in lighting-technology, high performance electronics, high temperature furnace construction and coating technology. However, its applicability as a structural material is limited because of the poor oxidation resistance at high temperatures and a brittle-to-ductile transition around room temperature, which is influenced by the grain size and the content of interstitial impurities at the grain boundaries. Due to the progress of the powder metallurgical production during the last decades, the amount of impurities in the current quality of molybdenum has become so small that surface sensitivemore » techniques are not applicable anymore. Therefore, the atom probe, which allows the detection of small amounts of impurities as well as their location, seems to be a more suitable technique. However, a site-specific specimen preparation procedure for grain boundaries in refractory metals with a dual focused ion beam/scanning electron microscope is still required. The present investigation describes the development and successful application of such a site-specific preparation technique for grain boundaries in molybdenum, which is significantly improved by a combination with transmission electron microscopy. This complimentary technique helps to improve the visibility of grain boundaries during the last preparation steps and to evidence the presence of grain and subgrain boundaries without segregants in atom probe specimens. Furthermore, in industrially processed and recrystallized molybdenum sheets grain boundary segregation of oxygen, nitrogen and potassium is successfully detected close to segregated regions which are believed to be former sinter pores. - Highlights: • First study of grain boundary segregation in molybdenum by atom probe • Site-specific preparation technique by FIB and TEM successfully developed • Grain boundary

  4. Piezoelectric particle accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kemp, Mark A.; Jongewaard, Erik N.; Haase, Andrew A.

    2017-08-29

    A particle accelerator is provided that includes a piezoelectric accelerator element, where the piezoelectric accelerator element includes a hollow cylindrical shape, and an input transducer, where the input transducer is disposed to provide an input signal to the piezoelectric accelerator element, where the input signal induces a mechanical excitation of the piezoelectric accelerator element, where the mechanical excitation is capable of generating a piezoelectric electric field proximal to an axis of the cylindrical shape, where the piezoelectric accelerator is configured to accelerate a charged particle longitudinally along the axis of the cylindrical shape according to the piezoelectric electric field.

  5. Chromenoquinoline-based thiol probes: a study on the quencher position for controlling fluorescent Off-On characteristics.

    PubMed

    Kand, Dnyaneshwar; Kalle, Arunasree Marasanapalli; Talukdar, Pinaki

    2013-02-13

    The design, synthesis and thiol sensing ability of chromenoquinoline-based fluorescent probes 4, 5 and 6 and are reported here. The relative position of the maleimide moiety was varied along the chromenoquinoline fluorophore to decrease the background fluorescence. Lower background fluorescence in probes 4 and 6 was rationalized by the smaller k(r)/k(nr) values compared to that of probe 5. An intramolecular charge transfer (ICT) mechanism was proposed for quenching and the extent was dependent on the position of the maleimide quencher. Fluorescent Off-On characteristics were evaluated by theoretical calculations. All probes were selective only towards thiol containing amino acids. Thiol sensing by probes 4 and 6 were much better compared to 5. Probe 4 displayed a better fluorescence response for less hindered thiol (185-, 223- and 156-fold for Hcy, Cys and GSH, respectively), while for probe 6, a higher enhancement in fluorescence was observed with more hindered thiols (180-, 205- and 245-fold for Hcy, Cys and GSH, respectively). The better response to bulkier thiol, GSH by probe 6 was attributed to the steric crowding at the C-4 position and bulkiness of the GSH group which force the succinimide unit to be in a nearly orthogonal conformation. This spatial arrangement was important in reducing the fluorescence quenching ability of the succinimide moiety. The application of probes 4, 5 and 6 was demonstrated by naked eye detection thiols using a 96-well plate system as well as by live-cell imaging.

  6. Effective Teaching in Accelerated Learning Programs

    ERIC Educational Resources Information Center

    Boyd, Drick

    2004-01-01

    According to Wlodkowski (2003), "accelerated learning programs are one of the fastest growing transformations in higher education" (p. 5). The Center for the Study of Accelerated Learning at Regis University has documented at least 250 colleges or universities that offer accelerated learning programs for working adults. By definition, accelerated…

  7. Floating Potential Probe Langmuir Probe Data Reduction Results

    NASA Technical Reports Server (NTRS)

    Morton, Thomas L.; Minow, Joseph I.

    2002-01-01

    During its first five months of operations, the Langmuir Probe on the Floating Potential Probe (FPP) obtained data on ionospheric electron densities and temperatures in the ISS orbit. In this paper, the algorithms for data reduction are presented, and comparisons are made of FPP data with ground-based ionosonde and Incoherent Scattering Radar (ISR) results. Implications for ISS operations are detailed, and the need for a permanent FPP on ISS is examined.

  8. LSST Probes of Dark Energy: New Energy vs New Gravity

    NASA Astrophysics Data System (ADS)

    Bradshaw, Andrew; Tyson, A.; Jee, M. J.; Zhan, H.; Bard, D.; Bean, R.; Bosch, J.; Chang, C.; Clowe, D.; Dell'Antonio, I.; Gawiser, E.; Jain, B.; Jarvis, M.; Kahn, S.; Knox, L.; Newman, J.; Wittman, D.; Weak Lensing, LSST; LSS Science Collaborations

    2012-01-01

    Is the late time acceleration of the universe due to new physics in the form of stress-energy or a departure from General Relativity? LSST will measure the shape, magnitude, and color of 4x109 galaxies to high S/N over 18,000 square degrees. These data will be used to separately measure the gravitational growth of mass structure and distance vs redshift to unprecedented precision by combining multiple probes in a joint analysis. Of the five LSST probes of dark energy, weak gravitational lensing (WL) and baryon acoustic oscillation (BAO) probes are particularly effective in combination. By measuring the 2-D BAO scale in ugrizy-band photometric redshift-selected samples, LSST will determine the angular diameter distance to a dozen redshifts with sub percent-level errors. Reconstruction of the WL shear power spectrum on linear and weakly non-linear scales, and of the cross-correlation of shear measured in different photometric redshift bins provides a constraint on the evolution of dark energy that is complementary to the purely geometric measures provided by supernovae and BAO. Cross-correlation of the WL shear and BAO signal within redshift shells minimizes the sensitivity to systematics. LSST will also detect shear peaks, providing independent constraints. Tomographic study of the shear of background galaxies as a function of redshift allows a geometric test of dark energy. To extract the dark energy signal and distinguish between the two forms of new physics, LSST will rely on accurate stellar point-spread functions (PSF) and unbiased reconstruction of galaxy image shapes from hundreds of exposures. Although a weighted co-added deep image has high S/N, it is a form of lossy compression. Bayesian forward modeling algorithms can in principle use all the information. We explore systematic effects on shape measurements and present tests of an algorithm called Multi-Fit, which appears to avoid PSF-induced shear systematics in a computationally efficient way.

  9. A plasma deflagration accelerator as a platform for laboratory astrophysics

    NASA Astrophysics Data System (ADS)

    Underwood, Thomas C.; Loebner, Keith T. K.; Cappelli, Mark A.

    2017-06-01

    The replication of astrophysical flows in the laboratory is critical for isolating particular phenomena and dynamics that appear in complex, highly-coupled natural systems. In particular, plasma jets are observed in astrophysical contexts at a variety of scales, typically at high magnetic Reynolds number and driven by internal currents. In this paper, we present detailed measurements of the plasma parameters within deflagration-produced plasma jets, the scaling of these parameters against both machine operating conditions and the corresponding astrophysical phenomena. Using optical and spectroscopic diagnostics, including Schlieren cinematography, we demonstrate the production of current-driven plasma jets of ∼100 km/s and magnetic Reynolds numbers of ∼100, and discuss the dynamics of their acceleration into vacuum. The results of this study will contribute to the reproduction of various types of astrophysical jets in the laboratory and indicate the ability to further probe active research areas such as jet collimation, stability, and interaction.

  10. Robot friendly probe and socket assembly

    NASA Technical Reports Server (NTRS)

    Nyberg, Karen L. (Inventor)

    1994-01-01

    A probe and socket assembly for serving as a mechanical interface between structures is presented. The assembly comprises a socket having a housing adapted for connection to a first supporting structure and a probe which is readily connectable to a second structure and is designed to be easily grappled and manipulated by a robotic device for insertion and coupling with the socket. Cooperable automatic locking means are provided on the probe shaft and socket housing for automatically locking the probe in the socket when the probe is inserted a predetermined distance. A second cooperable locking means on the probe shaft and housing are adapted for actuation after the probe has been inserted the predetermined distance. Actuation means mounted on the probe and responsive to the grip of the probe handle by a gripping device, such as a robot for conditioning the probe for insertion and are also responsive to release of the grip of the probe handle to actuate the second locking means to provide a hard lock of the probe in the socket.

  11. 3 MV hypervelocity dust accelerator at the Colorado Center for Lunar Dust and Atmospheric Studies.

    PubMed

    Shu, Anthony; Collette, Andrew; Drake, Keith; Grün, Eberhard; Horányi, Mihály; Kempf, Sascha; Mocker, Anna; Munsat, Tobin; Northway, Paige; Srama, Ralf; Sternovsky, Zoltán; Thomas, Evan

    2012-07-01

    A hypervelocity dust accelerator for studying micrometeorite impacts has been constructed at the Colorado Center for Lunar Dust and Atmospheric Studies (CCLDAS) at the University of Colorado. Based on the Max-Planck-Institüt für Kernphysik (MPI-K) accelerator, this accelerator is capable of emitting single particles of a specific mass and velocity selected by the user. The accelerator consists of a 3 MV Pelletron generator with a dust source, four image charge pickup detectors, and two interchangeable target chambers: a large high-vacuum test bed and an ultra-high vacuum impact study chamber. The large test bed is a 1.2 m diameter, 1.5 m long cylindrical vacuum chamber capable of pressures as low as 10(-7) torr while the ultra-high vacuum chamber is a 0.75 m diameter, 1.1 m long chamber capable of pressures as low as 10(-10) torr. Using iron dust of up to 2 microns in diameter, final velocities have been measured up to 52 km/s. The spread of the dust particles and the effect of electrostatic focusing have been measured using a long exposure CCD and a quartz target. Furthermore, a new technique of particle selection is being developed using real time digital filtering techniques. Signals are digitized and then cross-correlated with a shaped filter, resulting in a suppressed noise floor. Improvements over the MPI-K design, which include a higher operating voltage and digital filtering for detection, increase the available parameter space of dust emitted by the accelerator. The CCLDAS dust facility is a user facility open to the scientific community to assist with instrument calibrations and experiments.

  12. Comparison of peroxidase-labeled DNA probes with radioactive RNA probes for detection of human papillomaviruses by in situ hybridization in paraffin sections.

    PubMed

    Park, J S; Kurman, R J; Kessis, T D; Shah, K V

    1991-01-01

    A study comparing in situ hybridization using nonradioactive DNA probes directly conjugated with horseradish peroxidase (HRP), and 35S-labeled antisense RNA probes for human papillomavirus (HPV) types 6/11, 16, and 18 was performed on formalin-fixed, paraffin-embedded tissue from 34 lesions of the cervix and vulva. These lesions included exophytic condylomas and intraepithelial and invasive neoplasms. HPV 6/11 was detected in two of four condylomata acuminata by both in situ techniques. HPV 16 was detected in 13 of 30 cases of intraepithelial and invasive neoplasms by both methods. Discordance between the two methods occurred in two instances. The radiolabeled probe but not the HRP probe detected HPV 16 in one case of cervical intraepithelial neoplasia (CIN 3), whereas the converse occurred in one case of vulvar intraepithelial neoplasia (VIN 3). HPV 18 was not detected in any of the specimens by either method. This study demonstrates that nonradioactive HRP-labeled probes for the detection of specific HPV types are as sensitive as the more laborious and potentially hazardous radioactive probes.

  13. Comparison of peroxidase-labeled DNA probes with radioactive RNA probes for detection of human papillomaviruses by in situ hybridization in paraffin sections

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, J.S.; Kurman, R.J.; Kessis, T.D.

    1991-01-01

    A study comparing in situ hybridization using nonradioactive DNA probes directly conjugated with horseradish peroxidase (HRP), and {sup 35}S-labeled antisense RNA probes for human papillomavirus (HPV) types 6/11, 16, and 18 was performed on formalin-fixed, paraffin-embedded tissue from 34 lesions of the cervix and vulva. These lesions included exophytic condylomas and intraepithelial and invasive neoplasms. HPV 6/11 was detected in two of four condylomata acuminata by both in situ techniques. HPV 16 was detected in 13 of 30 cases of intraepithelial and invasive neoplasms by both methods. Discordance between the two methods occurred in two instances. The radiolabeled probe butmore » not the HRP probe detected HPV 16 in one case of cervical intraepithelial neoplasia (CIN 3), whereas the converse occurred in one case of vulvar intraepithelial neoplasia (VIN 3). HPV 18 was not detected in any of the specimens by either method. This study demonstrates that nonradioactive HRP-labeled probes for the detection of specific HPV types are as sensitive as the more laborious and potentially hazardous radioactive probes.« less

  14. Monte Carlo study of neutrino acceleration in supernova shocks

    NASA Technical Reports Server (NTRS)

    Kazanas, D.; Ellison, D. C.

    1981-01-01

    The first order Fermi acceleration mechanism of cosmic rays in shocks may be at work for neutrinos in supernova shocks when the latter are at densities greater than 10 to the 13th g/cu cm, at which the core material is opaque to neutrinos. A Monte Carlo approach to study this effect is employed, and the emerging neutrino power law spectra are presented. The increased energy acquired by the neutrinos may facilitate their detection in supernova explosions and provide information about the physics of collapse.

  15. Accelerated hydrolysis of substituted cellulose for potential biofuel production: kinetic study and modeling.

    PubMed

    Mu, Bingnan; Xu, Helan; Yang, Yiqi

    2015-11-01

    In this work, kinetics of substitution accelerated cellulose hydrolysis with multiple reaction stages was investigated to lay foundation for mechanism study and molecular design of substituting compounds. High-efficiency hydrolysis of cellulose is critical for cellulose-based bioethanol production. It is known that, substitution could substantially decrease activation energy and increase reaction rate of acidic hydrolysis of glycosidic bonds in cellulose. However, reaction kinetics and mechanism of the accelerated hydrolysis were not fully revealed. In this research, it was proved that substitution therefore accelerated hydrolysis only occurred in amorphous regions of cellulose fibers, and was a process with multiple reaction stages. With molar ratio of substitution less than 1%, the overall hydrolysis rate could be increased for around 10 times. We also quantified the relationship between the hydrolysis rate of individual reaction stage and its major influences, including molar ratio of substitution, activation energy of acidic hydrolysis, pH and temperature. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. [Now, The Time for Probes and In-Situ Science

    NASA Technical Reports Server (NTRS)

    Hubbard, G. Scott

    2005-01-01

    A viewgraph explaining the need for probes and in situ measurements to understand data from extra solar planet studies is shown. The topics include: 1) To explore the universe and search for life: Probes in Context; 2) What is a probe?; 3) NASA Ames Research Center-founded 1939; 4) Past & Present: Successful Probes and Fly-by's; 5) Thermal Protection Materials and Arc-Jet Facility; 6) Mars Exploration Rovers-Spirit & Opportunity; 7) Bio/Info/Nanotechnology; 8) Technology for Exploration; 9) Award Winning NASA Research Park; 10) Where we need to go; and 11) The Future: Pico Probes

  17. Urine culture contamination: a College of American Pathologists Q-Probes study of 127 laboratories.

    PubMed

    Bekeris, Leonas G; Jones, Bruce Allen; Walsh, Molly K; Wagar, Elizabeth A

    2008-06-01

    While urine culture contamination may not be completely avoidable, some laboratories have lower contamination rates than others. A College of American Pathologists (CAP) 1998 Q-Probes study showed that many interventions commonly assumed to reduce contamination were not demonstrably effective. This article revisits the issue. To examine the frequency of urine culture contamination, review current laboratory practices in the collection of urine culture specimens, and determine practice characteristics that may be associated with the contamination rate. Laboratories participating in a CAP Q-Probes study were required to prospectively collect data on 120 consecutive urine culture specimens and provide information on the patient's demographics (age and sex), the location where the specimen was collected, how the specimen was handled, the number of isolates in quantities greater than or equal to 10,000 colony-forming units (CFU)/mL, and whether the laboratory considered the specimen to be contaminated. Specific inclusion and exclusion criteria were provided to the participants. Each laboratory completed a supplemental questionnaire that probed for specific laboratory urine culture collection practices. One hundred twenty-seven laboratories participated in the study. Results from a total of 14,739 urine specimens were received. For the purpose of this study, a urine specimen was determined to be contaminated if the culture yielded more than 2 isolates in quantities greater than or equal to 10,000 CFU/mL. Using these criteria the median institution had a contamination rate of 15.0%. Laboratories in the 10th percentile (low performance) had an average contamination rate of 41.7%, while laboratories in the 90th percentile had an average rate of 0.8%. The collection site had no influence on the contamination rate, but postcollection processing, especially refrigeration of the specimen, had a substantial effect. Providing instruction to patients produced a statistically

  18. Accelerator-based conversion (ABC) of weapons plutonium: Plant layout study and related design issues

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cowell, B.S.; Fontana, M.H.; Krakowski, R.A.

    1995-04-01

    In preparation for and in support of a detailed R and D Plan for the Accelerator-Based Conversion (ABC) of weapons plutonium, an ABC Plant Layout Study was conducted at the level of a pre-conceptual engineering design. The plant layout is based on an adaptation of the Molten-Salt Breeder Reactor (MSBR) detailed conceptual design that was completed in the early 1070s. Although the ABC Plant Layout Study included the Accelerator Equipment as an essential element, the engineering assessment focused primarily on the Target; Primary System (blanket and all systems containing plutonium-bearing fuel salt); the Heat-Removal System (secondary-coolant-salt and supercritical-steam systems); Chemicalmore » Processing; Operation and Maintenance; Containment and Safety; and Instrumentation and Control systems. Although constrained primarily to a reflection of an accelerator-driven (subcritical) variant of MSBR system, unique features and added flexibilities of the ABC suggest improved or alternative approaches to each of the above-listed subsystems; these, along with the key technical issues in need of resolution through a detailed R&D plan for ABC are described on the bases of the ``strawman`` or ``point-of-departure`` plant layout that resulted from this study.« less

  19. Study of the transverse beam motion in the DARHT Phase II accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Yu-Jiuan; Fawley, W M; Houck, T L

    1998-08-20

    The accelerator for the second-axis of the Dual Axis Radiographic Hydrodynamic Test (DARHT) facility will accelerate a 4-kA, 3-MeV, 2--µs long electron current pulse to 20 MeV. The energy variation of the beam within the flat-top portion of the current pulse is (plus or equal to) 0.5%. The performance of the DARHT Phase II radiographic machine requires the transverse beam motion to be much less than the beam spot size which is about 1.5 mm diameter on the x-ray converter. In general, the leading causes of the transverse beam motion in an accelerator are the beam breakup instability (BBU) andmore » the corkscrew motion. We have modeled the transverse beam motion in the DARHT Phase II accelerator with various magnetic tunes and accelerator cell configurations by using the BREAKUP code. The predicted sensitivity of corkscrew motion and BBU growth to different tuning algorithms will be presented.« less

  20. Optical pump terahertz probe studies of semiconducting polymers

    NASA Astrophysics Data System (ADS)

    Cunningham, Paul D.

    Optical-pump terahertz-probe spectroscopy (OPTP) has been applied to study charge generation, transport and the evolution of the photo-induced excited states in thin film organic semiconductors, with emphasis on their relevance to photovoltaic technology. In these experiments the response of the photoexcited material to the AC electric field of a terahertz (THz) pulse was measured. From this response, the evolution of the complex conductivity in the far-infrared was monitored. OPTP presents advantages over other techniques by being an all-optical probe of the complex conductivity over nanometer scale distances with sub-picosecond resolution and exhibits particular sensitivity to carrier scattering rates, which typically lay in the THz range. Conductivity models were applied to the extracted conductivity curves in order to determine technologically relevant quantities like the charge carrier mobility and external quantum yield of charge carrier generation. We observed charge carriers generated on a subpicosecond time scale in thin films of polyhexylthiophene (P3HT). Through application of the Drude-Smith model (DSM) over the 0-2 THz band, we determined a room temperature intrinsic mobility of about 30 cm2/Vs. The temperature dependence of the conductivity dynamics showed signs of thermally activated polaron hopping influenced by torsional disorder. Both above and below gap excitation resulted in similar dynamics, showing that the majority of carriers recombine within 1 ps. We were able to observe charge transfer occurring on a sub-ps timescale to the soluble fullerene, PCBM, for both excited states, demonstrating that narrow gap polymers can be blended with PCBM for photovoltaic applications. We observed charge carrier generated on a sub-ps time scale in thin amorphous films of metalated polymers. The time evolution of the conductivity showed that charge carriers recombine and only excitons persist after 100 ps. This characteristic appears to be common to amorphous

  1. Use of vaccines as probes to define disease burden

    PubMed Central

    Feikin, Daniel R; Scott, J Anthony G; Gessner, Bradford D

    2015-01-01

    Vaccine probe studies have emerged in the past 15 years as a useful way to characterise disease. By contrast, traditional studies of vaccines focus on defining the vaccine effectiveness or efficacy. The underlying basis for the vaccine probe approach is that the difference in disease burden between vaccinated and unvaccinated individuals can be ascribed to the vaccine-specific pathogen. Vaccine probe studies can increase understanding of a vaccine’s public health value. For instance, even when a vaccine has a seemingly low efficacy, a high baseline disease incidence can lead to a large vaccine-preventable disease burden and thus that population-based vaccine introduction would be justified. So far, vaccines have been used as probes to characterise disease syndromes caused by Haemophilus influenzae type b, pneumococcus, rotavirus, and early infant influenza. However, vaccine probe studies have enormous potential and could be used more widely in epidemiology, for example, to define the vaccine-preventable burden of malaria, typhoid, paediatric influenza, and dengue, and to identify causal interactions between different pathogens. PMID:24553294

  2. Database architecture and query structures for probe data processing.

    DOT National Transportation Integrated Search

    2012-03-01

    This report summarizes findings and implementations of probe vehicle data collection based on Bluetooth MAC address matching technology. Probe vehicle travel time data are studied in the following field deployment case studies: analysis of traffic ch...

  3. Probing Student Teachers' Subject Content Knowledge in Chemistry: Case Studies Using Dynamic Computer Models

    ERIC Educational Resources Information Center

    Toplis, Rob

    2008-01-01

    This paper reports case study research into the knowledge and understanding of chemistry for six secondary science student teachers. It combines innovative student-generated computer animations, using "ChemSense" software, with interviews to probe understanding of four common chemical processes used in the secondary school curriculum. Findings…

  4. Bunker probe: A plasma potential probe almost insensitive to its orientation with the magnetic field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Costea, S., E-mail: stefan.costea@uibk.ac.at; Schneider, B. S.; Schrittwieser, R.

    Due to their ability to suppress a large part of the electron current and thus measuring directly the plasma potential, ion sensitive probes have begun to be widely tested and used in fusion devices. For these probes to work, almost perfect alignment with the total magnetic field is necessary. This condition cannot always be fulfilled due to the curvature of magnetic fields, complex magnetic structure, or magnetic field reconnection. In this perspective, we have developed a plasma potential probe (named Bunker probe) based on the principle of the ion sensitive probe but almost insensitive to its orientation with the totalmore » magnetic field. Therefore it can be used to measure the plasma potential inside fusion devices, especially in regions with complex magnetic field topology. Experimental results are presented and compared with Ball-Pen probe measurements taken under identical conditions. We have observed that the floating potential of the Bunker probe is indeed little affected by its orientation with the magnetic field for angles ranging from 90° to 30°, in contrast to the Ball-Pen probe whose floating potential decreases towards that of a Langmuir probe if not properly aligned with the magnetic field.« less

  5. Source-to-accelerator quadrupole matching section for a compact linear accelerator

    NASA Astrophysics Data System (ADS)

    Seidl, P. A.; Persaud, A.; Ghiorso, W.; Ji, Q.; Waldron, W. L.; Lal, A.; Vinayakumar, K. B.; Schenkel, T.

    2018-05-01

    Recently, we presented a new approach for a compact radio-frequency (RF) accelerator structure and demonstrated the functionality of the individual components: acceleration units and focusing elements. In this paper, we combine these units to form a working accelerator structure: a matching section between the ion source extraction grids and the RF-acceleration unit and electrostatic focusing quadrupoles between successive acceleration units. The matching section consists of six electrostatic quadrupoles (ESQs) fabricated using 3D-printing techniques. The matching section enables us to capture more beam current and to match the beam envelope to conditions for stable transport in an acceleration lattice. We present data from an integrated accelerator consisting of the source, matching section, and an ESQ doublet sandwiched between two RF-acceleration units.

  6. Radical probing of spliceosome assembly.

    PubMed

    Grewal, Charnpal S; Kent, Oliver A; MacMillan, Andrew M

    2017-08-01

    Here we describe the synthesis and use of a directed hydroxyl radical probe, tethered to a pre-mRNA substrate, to map the structure of this substrate during the spliceosome assembly process. These studies indicate an early organization and proximation of conserved pre-mRNA sequences during spliceosome assembly. This methodology may be adapted to the synthesis of a wide variety of modified RNAs for use as probes of RNA structure and RNA-protein interaction. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Hydrophobic pocket targeting probes for enteroviruses.

    PubMed

    Martikainen, Mari; Salorinne, Kirsi; Lahtinen, Tanja; Malola, Sami; Permi, Perttu; Häkkinen, Hannu; Marjomäki, Varpu

    2015-11-07

    , the probe may be released upon virus uncoating. Our results collectively thus show that the gold and fluorescently labeled probes may be used to track and visualize the studied enteroviruses during the early phases of infection opening new avenues to follow virus uncoating in cells.

  8. BEAM CONTROL PROBE

    DOEpatents

    Chesterman, A.W.

    1959-03-17

    A probe is described for intercepting a desired portion of a beam of charged particles and for indicating the spatial disposition of the beam. The disclosed probe assembly includes a pair of pivotally mounted vanes moveable into a single plane with adjacent edges joining and a calibrated mechanical arrangement for pivoting the vancs apart. When the probe is disposed in the path of a charged particle beam, the vanes may be adjusted according to the beam current received in each vane to ascertain the dimension of the beam.

  9. Ultrafast hopping dynamics of 5f electrons in the Mott insulator UO₂ studied by femtosecond pump-probe spectroscopy.

    PubMed

    An, Yong Q; Taylor, Antoinette J; Conradson, Steven D; Trugman, Stuart A; Durakiewicz, Tomasz; Rodriguez, George

    2011-05-20

    We describe a femtosecond pump-probe study of ultrafast hopping dynamics of 5f electrons in the Mott insulator UO₂ following Mott-gap excitation at temperatures of 5-300 K. Hopping-induced response of the lattice and electrons is probed by transient reflectivity at mid- and above-gap photon energies, respectively. These measurements show an instantaneous hop, subsequent picosecond lattice deformation, followed by acoustic phonon emission and microsecond relaxation. Temperature-dependent studies indicate that the slow relaxation results from Hubbard excitons formed by U³⁺-U⁵⁺ pairs.

  10. A study of response time of pitot pressure probes designed for rapid response and protection of transducer

    NASA Technical Reports Server (NTRS)

    Moore, J. A.

    1979-01-01

    An eight orifice probe, designed to protect the transducer without the use of a baffle, was compared to a standard orifice-baffle probe in the small shock tube and in the expansion tube under normal run conditions. In both facilities, the response time of eight orifice probe was considerable better than the standard probe design.

  11. Arterial compliance probe for local blood pulse wave velocity measurement.

    PubMed

    Nabeel, P M; Joseph, Jayaraj; Sivaprakasam, Mohanasankar

    2015-08-01

    Arterial compliance and vessel wall dynamics are significant in vascular diagnosis. We present the design of arterial compliance probes for measurement of local pulse wave velocity (PWV). Two designs of compliance probe are discussed, viz (a) a magnetic plethysmograph (MPG) based probe, and (b) a photoplethysmograph (PPG) based probe. The ability of the local PWV probes to consistently capture carotid blood pulse waves is verified by in-vivo trials on few volunteers. The probes could reliably perform repeatable measurements of local PWV from carotid artery along small artery sections less than 20 mm. Further, correlation between the measured values of local PWV using probes and various measures of blood pressure (BP) was also investigated. The study indicates that such arterial compliance probes have strong potential in cuff less BP monitoring.

  12. A comparative study between an improved novel air-cushion sensor and a wheeled probe for minimally invasive surgery.

    PubMed

    Zbyszewski, Dinusha; Challacombe, Benjamin; Li, Jichun; Seneviratne, Lakmal; Althoefer, Kaspar; Dasgupta, Prokar; Murphy, Declan

    2010-07-01

    We describe a comparative study between an enhanced air-cushion tactile sensor and a wheeled indentation probe. These laparoscopic tools are designed to rapidly locate soft-tissue abnormalities during minimally invasive surgery (MIS). The air-cushion tactile sensor consists of an optically based sensor with a 7.8 mm sphere "floating" on a cushion of air at the tip of a shaft. The wheeled indentation probe is a 10 mm wide and 5 mm in diameter wheel mounted to a force/torque sensor. A continuous rolling indentation technique is used to pass the sensors over the soft-tissue surfaces. The variations in stiffness of the viscoelastic materials that are detected during the rolling indentations are illustrated by stiffness maps that can be used for tissue diagnosis. The probes were tested by having to detect four embedded nodules in a silicone phantom. Each probe was attached to a robotic manipulator and rolled over the silicone phantom in parallel paths. The readings of each probe collected during the process of rolling indentation were used to achieve the final results. The results show that both sensors reliably detected the areas of variable stiffness by accurately identifying the location of each nodule. These are illustrated in the form of two three-dimensional spatiomechanical maps. These probes have the potential to be used in MIS because they could provide surgeons with information on the mechanical properties of soft tissue, consequently enhancing the reduction in haptic feedback.

  13. Novel Multisensor Probe for Monitoring Bladder Temperature During Locoregional Chemohyperthermia for Nonmuscle-Invasive Bladder Cancer: Technical Feasibility Study

    PubMed Central

    Geijsen, Debby E.; Zum Vörde Sive Vörding, Paul J.; Schooneveldt, Gerben; Sijbrands, Jan; Hulshof, Maarten C.; de la Rosette, Jean; de Reijke, Theo M.; Crezee, Hans

    2013-01-01

    Abstract Background and Purpose: The effectiveness of locoregional hyperthermia combined with intravesical instillation of mitomycin C to reduce the risk of recurrence and progression of intermediate- and high-risk nonmuscle-invasive bladder cancer is currently investigated in clinical trials. Clinically effective locoregional hyperthermia delivery necessitates adequate thermal dosimetry; thus, optimal thermometry methods are needed to monitor accurately the temperature distribution throughout the bladder wall. The aim of the study was to evaluate the technical feasibility of a novel intravesical device (multi-sensor probe) developed to monitor the local bladder wall temperatures during loco-regional C-HT. Materials and Methods: A multisensor thermocouple probe was designed for deployment in the human bladder, using special sensors to cover the bladder wall in different directions. The deployment of the thermocouples against the bladder wall was evaluated with visual, endoscopic, and CT imaging in bladder phantoms, porcine models, and human bladders obtained from obduction for bladder volumes and different deployment sizes of the probe. Finally, porcine bladders were embedded in a phantom and subjected to locoregional heating to compare probe temperatures with additional thermometry inside and outside the bladder wall. Results: The 7.5 cm thermocouple probe yielded optimal bladder wall contact, adapting to different bladder volumes. Temperature monitoring was shown to be accurate and representative for the actual bladder wall temperature. Conclusions: Use of this novel multisensor probe could yield a more accurate monitoring of the bladder wall temperature during locoregional chemohyperthermia. PMID:24112045

  14. [A simulation study with finite element model on the unequal loss of peripheral vision caused by acceleration].

    PubMed

    Geng, Xiaoqi; Liu, Xiaoyu; Liu, Songyang; Xu, Yan; Zhao, Xianliang; Wang, Jie; Fan, Yubo

    2017-04-01

    An unequal loss of peripheral vision may happen with high sustaining multi-axis acceleration, leading to a great potential flight safety hazard. In the present research, finite element method was used to study the mechanism of unequal loss of peripheral vision. Firstly, a 3D geometric model of skull was developed based on the adult computer tomography (CT) images. The model of double eyes was created by mirroring with the previous right eye model. Then, the double-eye model was matched to the skull model, and fat was filled between eyeballs and skull. Acceleration loads of head-to-foot (G z ), right-to-left (G y ), chest-to-back (G x ) and multi-axis directions were applied to the current model to simulate dynamic response of retina by explicit dynamics solution. The results showed that the relative strain of double eyes was 25.7% under multi-axis acceleration load. Moreover, the strain distributions showed a significant difference among acceleration loaded in different directions. It indicated that a finite element model of double eyes was an effective means to study the mechanism of an unequal loss of peripheral vision at sustaining high multi-axis acceleration.

  15. Achievement Levels of Middle School Students in the Standardized Science and Technology Exam and Formative Assessment Probes: A Comparative Study

    ERIC Educational Resources Information Center

    Bulunuz, Nermin; Bulunuz, Mizrap; Karagoz, Funda; Tavsanli, Omer Faruk

    2016-01-01

    The present study has two aims. Firstly, it aims to determine eighth grade students' conceptual understanding of floating and sinking through formative assessment probes. Secondly, it aims to determine whether or not there is a significant difference between students' performance in formative assessment probes and their achievement in the…

  16. The photostability of the commonly used biotin-4-fluorescein probe.

    PubMed

    Haack, Richard A; Swift, Kerry M; Ruan, Qiaoqiao; Himmelsbach, Richard J; Tetin, Sergey Y

    2017-08-15

    Biotin-4-fluorescein (B4F) is a commonly used fluorescent probe for studying biotin-(strept)avidin interactions. During a characterization study of an anti-biotin antibody, using B4F as the probe, we noticed a discrepancy in the expected and experimentally determined number of biotin binding sites. Analytical testing showed that the biotin moiety in the probe undergoes a photosensitized oxidation to produce a mixture of biotin sulfoxides which has the potential to impact the quantitation of binding sites using this fluorescent probe. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Comparative study of long-term outcomes of accelerated and conventional collagen crosslinking for progressive keratoconus.

    PubMed

    Males, J J; Viswanathan, D

    2018-01-01

    PurposeTo compare the long-term outcomes of accelerated corneal collagen crosslinking (CXL) to conventional CXL for progressive keratoconus.Patients and methodsComparative clinical study of consecutive progressive keratoconic eyes that underwent either accelerated CXL (9 mW/cm 2 ultraviolet A (UVA) light irradiance for 10 min) or conventional CXL (3 mW/cm 2 UVA light irradiance for 30 min). Eyes with minimum 12 months' follow-up were included. Post-procedure changes in keratometry readings (Flat meridian: K1; steep meridian: K2), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and manifest refraction spherical equivalent (MRSE) were analysed.ResultsA total of 42 eyes were included. In all, 21 eyes had accelerated CXL (20.5±5.5 months' follow-up) and 21 eyes had conventional CXL group (20.2±5.6 months' follow-up). In the accelerated CXL group, a significant reduction in K2 (P=0.02), however no significant change in K1 (P=0.35) and CCT (P=0.62) was noted. In the conventional CXL group, a significant reduction was seen in K1 (P=0.01) and K2 (P=0.04), but not in CCT (P=0.95). Although both groups exhibited significant reductions in K2 readings, no noteworthy differences were noted between them (P=0.36). Improvements in BSCVA (accelerated CXL; P=0.22 and conventional CXL; P=0.20) and MRSE (accelerated CXL; P=0.97 and conventional CXL; P=0.54) were noted, however were not significant in either group.ConclusionAccelerated and conventional CXL appear to be effective procedures for stabilising progressive keratoconus in the long-term.

  18. Building versatile bipartite probes for quantum metrology

    NASA Astrophysics Data System (ADS)

    Farace, Alessandro; De Pasquale, Antonella; Adesso, Gerardo; Giovannetti, Vittorio

    2016-01-01

    We consider bipartite systems as versatile probes for the estimation of transformations acting locally on one of the subsystems. We investigate what resources are required for the probes to offer a guaranteed level of metrological performance, when the latter is averaged over specific sets of local transformations. We quantify such a performance via the average skew information (AvSk), a convex quantity which we compute in closed form for bipartite states of arbitrary dimensions, and which is shown to be strongly dependent on the degree of local purity of the probes. Our analysis contrasts and complements the recent series of studies focused on the minimum, rather than the average, performance of bipartite probes in local estimation tasks, which was instead determined by quantum correlations other than entanglement. We provide explicit prescriptions to characterize the most reliable states maximizing the AvSk, and elucidate the role of state purity, separability and correlations in the classification of optimal probes. Our results can help in the identification of useful resources for sensing, estimation and discrimination applications when complete knowledge of the interaction mechanism realizing the local transformation is unavailable, and access to pure entangled probes is technologically limited.

  19. Fast and reliable method of conductive carbon nanotube-probe fabrication for scanning probe microscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dremov, Vyacheslav, E-mail: dremov@issp.ac.ru; Fedorov, Pavel; Grebenko, Artem

    2015-05-15

    We demonstrate the procedure of scanning probe microscopy (SPM) conductive probe fabrication with a single multi-walled carbon nanotube (MWNT) on a silicon cantilever pyramid. The nanotube bundle reliably attached to the metal-covered pyramid is formed using dielectrophoresis technique from the MWNT suspension. It is shown that the dimpled aluminum sample can be used both for shortening/modification of the nanotube bundle by applying pulse voltage between the probe and the sample and for controlling the probe shape via atomic force microscopy imaging the sample. Carbon nanotube attached to cantilever covered with noble metal is suitable for SPM imaging in such modulationmore » regimes as capacitance contrast microscopy, Kelvin probe microscopy, and scanning gate microscopy. The majority of such probes are conductive with conductivity not degrading within hours of SPM imaging.« less

  20. Advanced scanning probe lithography.

    PubMed

    Garcia, Ricardo; Knoll, Armin W; Riedo, Elisa

    2014-08-01

    The nanoscale control afforded by scanning probe microscopes has prompted the development of a wide variety of scanning-probe-based patterning methods. Some of these methods have demonstrated a high degree of robustness and patterning capabilities that are unmatched by other lithographic techniques. However, the limited throughput of scanning probe lithography has prevented its exploitation in technological applications. Here, we review the fundamentals of scanning probe lithography and its use in materials science and nanotechnology. We focus on robust methods, such as those based on thermal effects, chemical reactions and voltage-induced processes, that demonstrate a potential for applications.

  1. Fluorescent-protein-based probes: general principles and practices.

    PubMed

    Ai, Hui-Wang

    2015-01-01

    An important application of fluorescent proteins is to derive genetically encoded fluorescent probes that can actively respond to cellular dynamics such as pH change, redox signaling, calcium oscillation, enzyme activities, and membrane potential. Despite the large diverse group of fluorescent-protein-based probes, a few basic principles have been established and are shared by most of these probes. In this article, the focus is on these general principles and strategies that guide the development of fluorescent-protein-based probes. A few examples are provided in each category to illustrate the corresponding principles. Since these principles are quite straightforward, others may adapt them to create fluorescent probes for their own interest. Hopefully, the development of the ever-growing family of fluorescent-protein-based probes will no longer be limited to a small number of laboratories specialized in senor development, leading to the situation that biological studies will be bettered assisted by genetically encoded sensors.

  2. School Restructuring: A Study of the Role of Parents in Selected Accelerated Schools.

    ERIC Educational Resources Information Center

    Davidson, Betty M.

    This paper presents findings of a study that examined the change process involved when four elementary schools implemented the accelerated schools model. Specifically, the study focused on transitions in parental roles that occurred when the schools changed from a conventional mode of organization to a participatory mode. The case study data were…

  3. pH Meter probe assembly

    DOEpatents

    Hale, C.J.

    1983-11-15

    An assembly for mounting a pH probe in a flowing solution, such as a sanitary sewer line, which prevents the sensitive glass portion of the probe from becoming coated with grease, oil, and other contaminants, whereby the probe gives reliable pH indication over an extended period of time. The pH probe assembly utilizes a special filter media and a timed back-rinse feature for flushing clear surface contaminants of the filter. The flushing liquid is of a known pH and is utilized to check performance of the probe. 1 fig.

  4. pH Meter probe assembly

    DOEpatents

    Hale, Charles J.

    1983-01-01

    An assembly for mounting a pH probe in a flowing solution, such as a sanitary sewer line, which prevents the sensitive glass portion of the probe from becoming coated with grease, oil, and other contaminants, whereby the probe gives reliable pH indication over an extended period of time. The pH probe assembly utilizes a special filter media and a timed back-rinse feature for flushing clear surface contaminants of the filter. The flushing liquid is of a known pH and is utilized to check performance of the probe.

  5. Can Accelerators Accelerate Learning?

    NASA Astrophysics Data System (ADS)

    Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

    2009-03-01

    The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ) [1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

  6. Evaluation of microwave oven heating for prediction of drug-excipient compatibilities and accelerated stability studies.

    PubMed

    Schou-Pedersen, Anne Marie V; Østergaard, Jesper; Cornett, Claus; Hansen, Steen Honoré

    2015-05-15

    Microwave ovens have been used extensively in organic synthesis in order to accelerate reaction rates. Here, a set up comprising a microwave oven combined with silicon carbide (SiC) plates for the controlled microwave heating of model formulations has been applied in order to investigate, if a microwave oven is applicable for accelerated drug stability testing. Chemical interactions were investigated in three selected model formulations of drug and excipients regarding the formation of ester and amide reaction products. In the accelerated stability studies, a design of experiments (DoE) approach was applied in order to be able to rank excipients regarding reactivity: Study A: cetirizine with PEG 400, sorbitol, glycerol and propylene glycol. Study B: 6-aminocaproic acid with citrate, acetate, tartrate and gluconate. Study C: atenolol with citric, tartaric, malic, glutaric, and sorbic acid. The model formulations were representative for oral solutions (co-solvents), parenteral solutions (buffer species) and solid dosage forms (organic acids applicable for solubility enhancement). The DoE studies showed overall that the same impurities were generated by microwave oven heating leading to temperatures between 150°C and 180°C as compared to accelerated stability studies performed at 40°C and 80°C using a conventional oven. Ranking of the reactivity of the excipients could be made in the DoE studies performed at 150-180°C, which was representative for the ranking obtained after storage at 40°C and 80°C. It was possible to reduce the time needed for drug-excipient compatibility testing of the three model formulations from weeks to less than an hour in the three case studies. The microwave oven is therefore considered to be an interesting alternative to conventional thermal techniques for the investigation of drug-excipient interactions during preformulation. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Electrophoresis-mass spectrometry probe

    DOEpatents

    Andresen, B.D.; Fought, E.R.

    1987-11-10

    The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface. 8 figs.

  8. Electrophoresis-mass spectrometry probe

    DOEpatents

    Andresen, Brian D.; Fought, Eric R.

    1987-01-01

    The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.

  9. Status of Solar Sail Propulsion: Moving Toward an Interstellar Probe

    NASA Technical Reports Server (NTRS)

    Johnson, Les; Young, Roy M.; Montgomery, Edward E., IV

    2006-01-01

    NASA's In-Space Propulsion Technology Program has developed the first-generation of solar sail propulsion systems sufficient to accomplish inner solar system science and exploration missions. These first-generation solar sails, when operational, will range in size from 40 meters to well over 100 meters in diameter and have an areal density of less than 13 grams-per-square meter. A rigorous, multiyear technology development effort culminated last year in the testing of two different 20-meter solar sail systems under thermal vacuum conditions. This effort provided a number of significant insights into the optimal design and expected performance of solar sails as well as an understanding of the methods and costs of building and using them. In a separate effort, solar sail orbital analysis tools for mission design were developed and tested. Laboratory simulations of the effects of long-term space radiation exposure were also conducted on two candidate solar sail materials. Detailed radiation and charging environments were defined for mission trajectories outside the protection of the earth's magnetosphere, in the solar wind environment. These were used in other analytical tools to prove the adequacy of sail design features for accommodating the harsh space environment. Preceding, and in conjunction with these technology efforts, NASA sponsored several mission application studies for solar sails, including one that would use an evolved sail capability to support humanity's first mission into nearby interstellar space. The proposed mission is called the Interstellar Probe. The Interstellar Probe might be accomplished in several ways. A 200-meter sail, with an areal density approaching 1 gram-per-square meter, could accelerate a robotic probe to the very edge of the solar system in just under 20 years from launch. A sail using the technology just demonstrated could make the same mission, but take significantly longer. Conventional chemical propulsion systems would require

  10. Fluoromodule-based reporter/probes designed for in vivo fluorescence imaging

    PubMed Central

    Zhang, Ming; Chakraborty, Subhasish K.; Sampath, Padma; Rojas, Juan J.; Hou, Weizhou; Saurabh, Saumya; Thorne, Steve H.; Bruchez, Marcel P.; Waggoner, Alan S.

    2015-01-01

    Optical imaging of whole, living animals has proven to be a powerful tool in multiple areas of preclinical research and has allowed noninvasive monitoring of immune responses, tumor and pathogen growth, and treatment responses in longitudinal studies. However, fluorescence-based studies in animals are challenging because tissue absorbs and autofluoresces strongly in the visible light spectrum. These optical properties drive development and use of fluorescent labels that absorb and emit at longer wavelengths. Here, we present a far-red absorbing fluoromodule–based reporter/probe system and show that this system can be used for imaging in living mice. The probe we developed is a fluorogenic dye called SC1 that is dark in solution but highly fluorescent when bound to its cognate reporter, Mars1. The reporter/probe complex, or fluoromodule, produced peak emission near 730 nm. Mars1 was able to bind a variety of structurally similar probes that differ in color and membrane permeability. We demonstrated that a tool kit of multiple probes can be used to label extracellular and intracellular reporter–tagged receptor pools with 2 colors. Imaging studies may benefit from this far-red excited reporter/probe system, which features tight coupling between probe fluorescence and reporter binding and offers the option of using an expandable family of fluorogenic probes with a single reporter gene. PMID:26348895

  11. Measurement of Transverse Wakefields Induced by a Misaligned Positron Bunch in a Hollow Channel Plasma Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lindstrom, C. A.; Adli, E.; Allen, J. M.

    Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, andmore » measured with another 20 GeV lower charge trailing positron probe bunch. Furthermore, the measurements are largely consistent with theory.« less

  12. Measurement of Transverse Wakefields Induced by a Misaligned Positron Bunch in a Hollow Channel Plasma Accelerator

    DOE PAGES

    Lindstrom, C. A.; Adli, E.; Allen, J. M.; ...

    2018-03-23

    Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, andmore » measured with another 20 GeV lower charge trailing positron probe bunch. Furthermore, the measurements are largely consistent with theory.« less

  13. Scientific Value of a Saturn Atmospheric Probe Mission

    NASA Technical Reports Server (NTRS)

    Simon-Miller, A. A.; Lunine, J. I.; Atreya, S. K.; Spilker, T. R.; Coustenis, A.; Atkinson, D. H.

    2012-01-01

    Atmospheric entry probe mISSions to the giant planets can uniquely discriminate between competing theories of solar system formation and the origin and evolution of the giant planets and their atmospheres. This provides for important comparative studies of the gas and ice giants, and to provide a laboratory for studying the atmospheric chemistries, dynamics, and interiors of all the planets including Earth. The giant planets also represent a valuable link to extrasolar planetary systems. As outlined in the recent Planetary Decadal Survey, a Saturn Probe mission - with a shallow probe - ranks as a high priority for a New Frontiers class mission [1].

  14. Preston Probe Calibrations at High Reynolds Number

    NASA Technical Reports Server (NTRS)

    Smits, Alexander J.

    1998-01-01

    The overall goal of the research effort is to study the performance of two Preston probes designed by NASA Langley Research Center across an unprecedented range of Reynolds number (based on friction velocity and probe diameter), and perform an accurate calibration over the same Reynolds number range. Using the Superpipe facility in Princeton, two rounds of experiments were performed. In each round of experiments for each Reynolds number, the pressure gradient, static pressure from the Preston probes and the total pressure from the Preston probes were measured. In the first round, 3 Preston probes having outer diameters of 0.058 inches, 0.083 inches and 0.203 inches were tested over a large range of pipe Reynolds numbers. Two data reduction methods were employed: first, the static pressure measured on the Preston probe was used to calculate P (modified Preston probe configuration), and secondly, the static pressure measured at the reference pressure tap was used to calculate P (un-modified Preston probe configuration). For both methods, the static pressure was adjusted to correspond with the static pressure at the Preston probe tip using the pressure gradient. The measurements for Preston probes with diameters of 0.058 inches, and 0.083 inches respectively were performed in the test pipe before it was polished a second time. Therefore, the measurements at high pipe Reynolds numbers may have been affected by roughness. In the second round of experiments the 0.058 inches and 0.083 inches diameter, un-modified probes were tested after the pipe was polished and prepared to ensure that the surface was smooth. The average velocity was estimated by assuming that the connection between the centerline velocity and the average velocity was known, and by using a Pitot tube to measure the centerline velocity. A preliminary error estimate suggests that it is possible to introduce a 1% to 2% error in estimating the average velocity using this approach. The evidence on the errors

  15. Accelerations in Flight

    NASA Technical Reports Server (NTRS)

    Doolittle, J H

    1925-01-01

    This work on accelerometry was done at McCook Field for the purpose of continuing the work done by other investigators and obtaining the accelerations which occur when a high-speed pursuit airplane is subjected to the more common maneuvers. The accelerations obtained in suddenly pulling out of a dive with well-balanced elevators are shown to be within 3 or 4 per cent of the theoretically possible accelerations. The maximum acceleration which a pilot can withstand depends upon the length of time the acceleration is continued. It is shown that he experiences no difficulty under the instantaneous accelerations as high as 7.8 G., but when under accelerations in excess of 4.5 G., continued for several seconds, he quickly loses his faculties.

  16. Alternative uses of a megavolt tandem accelerator for few-keV studies with ion-source SIMS monitoring.

    PubMed

    Mello, S L A; Codeço, C F S; Magnani, B F; Sant'Anna, M M

    2016-06-01

    We increase the versatility of a tandem electrostatic accelerator by implementing simple modifications to the standard operation procedure. While keeping its ability to deliver MeV ion beams, we show that the experimental setup can (i) provide good quality ion beams in the few-keV energy range and (ii) be used to study ion-beam surface modification with simultaneous secondary ion mass spectrometry. This latter task is accomplished without using any chamber connected to the accelerator exit. We perform mass spectrometry of the few-keV anions produced in the ion source by measuring their neutral counterparts at the accelerator exit with energies up to 1.7 MeV. With an additional modification, a high-current few-keV regime is obtained, using the ion source as an irradiation chamber and the accelerator itself only as a mass spectrometer. As an example of application, we prepare a sample for the study of ion-beam assisted dewetting of a thin Au film on a Si substrate.

  17. Alternative uses of a megavolt tandem accelerator for few-keV studies with ion-source SIMS monitoring

    NASA Astrophysics Data System (ADS)

    Mello, S. L. A.; Codeço, C. F. S.; Magnani, B. F.; Sant'Anna, M. M.

    2016-06-01

    We increase the versatility of a tandem electrostatic accelerator by implementing simple modifications to the standard operation procedure. While keeping its ability to deliver MeV ion beams, we show that the experimental setup can (i) provide good quality ion beams in the few-keV energy range and (ii) be used to study ion-beam surface modification with simultaneous secondary ion mass spectrometry. This latter task is accomplished without using any chamber connected to the accelerator exit. We perform mass spectrometry of the few-keV anions produced in the ion source by measuring their neutral counterparts at the accelerator exit with energies up to 1.7 MeV. With an additional modification, a high-current few-keV regime is obtained, using the ion source as an irradiation chamber and the accelerator itself only as a mass spectrometer. As an example of application, we prepare a sample for the study of ion-beam assisted dewetting of a thin Au film on a Si substrate.

  18. Global Acceleration of Coronal Mass Ejections

    NASA Technical Reports Server (NTRS)

    Gopalswamy, Nat; Lara, Alejandro; Lepping, Ronald; Kaiser, Michael; Berdichevsky, Daniel; St. Cyr, O. Chris; Lazarus, Al

    1999-01-01

    Using the observed relation between speeds of coronal mass ejections (CMEs) near the Sun and in the solar wind, we estimate a global acceleration acting on the CMEs. Our study quantifies the qualitative results of Gosling [1997] and numerical simulations that CMEs at 1 AU with speeds closer to the solar wind. We found a linear relation between the global acceleration and the initial speed of the CMEs and the absolute value of the acceleration is similar to the slow solar wind acceleration. Our study naturally divides CMEs into fast and slow ones, the dividing line being the solar wind speed. Our results have important implications to space weather prediction models which need to incorporate this effect in estimating the CME arrival time at 1 AU. We show that the arrival times of CMEs at 1 AU are drastically different from the zero acceleration case.

  19. Recent advances in biomedical applications of accelerator mass spectrometry.

    PubMed

    Hah, Sang Soo; Henderson, Paul T; Turteltaub, Kenneth W

    2009-06-17

    The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant, stable and long-lived isotopes, has now revolutionized high-sensitivity isotope detection in biomedical research, because it allows the direct determination of the amount of isotope in a sample rather than measuring its decay, and thus the quantitative analysis of the fate of the radiolabeled probes under the given conditions. Since AMS was first used in the early 90's for the analysis of biological samples containing enriched 14C for toxicology and cancer research, the biomedical applications of AMS to date range from in vitro to in vivo studies, including the studies of 1) toxicant and drug metabolism, 2) neuroscience, 3) pharmacokinetics, and 4) nutrition and metabolism of endogenous molecules such as vitamins. In addition, a new drug development concept that relies on the ultrasensitivity of AMS, known as human microdosing, is being used to obtain early human metabolism information of candidate drugs. These various aspects of AMS are reviewed and a perspective on future applications of AMS to biomedical research is provided.

  20. Recent advances in biomedical applications of accelerator mass spectrometry

    PubMed Central

    Hah, Sang Soo

    2009-01-01

    The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant, stable and long-lived isotopes, has now revolutionized high-sensitivity isotope detection in biomedical research, because it allows the direct determination of the amount of isotope in a sample rather than measuring its decay, and thus the quantitative analysis of the fate of the radiolabeled probes under the given conditions. Since AMS was first used in the early 90's for the analysis of biological samples containing enriched 14C for toxicology and cancer research, the biomedical applications of AMS to date range from in vitro to in vivo studies, including the studies of 1) toxicant and drug metabolism, 2) neuroscience, 3) pharmacokinetics, and 4) nutrition and metabolism of endogenous molecules such as vitamins. In addition, a new drug development concept that relies on the ultrasensitivity of AMS, known as human microdosing, is being used to obtain early human metabolism information of candidate drugs. These various aspects of AMS are reviewed and a perspective on future applications of AMS to biomedical research is provided. PMID:19534792