Sample records for acceleration proof-of-principle experiment

  1. Research on Vacuum Laser Accelerator and Proof-of Principle Experiment

    NASA Astrophysics Data System (ADS)

    Shao, Lei

    BNL-ATF fit our project very well. The laser system at ATF is a short pulse CO2 laser. Under present ATF condition, the peak power of the CO2 laser is around 5J with pulse duration 5ps. Therefore the maximum laser intensity can reach a 0 ≈ 1.0. Such level of laser intensity is not sufficient to perform violent electron acceleration-CAS according to the threshold we defined. However this level intensity is already high enough to see basic proof-of-principle signal based on our extensive simulations with exact practical ATF experimental conditions. Another important factor is the electron beam condition. ATF uses photoinjector Radio Frequency (RF) gun system for electron beam. The working frequency is at constant level 2856MHz. Generally the electron beam deliver energy around 40MeV˜60MeV to the transport beam line. However as we mentioned before with relatively low laser intensity the electron initial energy is required to be lower as well correspondently. We tried best to tuned ATF electron beam energy down to 15MeV. With laser intensity around a 0 ≈ 1.0 and electron beam 15MeV, our simulation indicates to see energy spread expansion after interaction, and this effect increases while the laser intensity increases (even slightly change from a 0 ≈ 0.9 to 2.2). The experiment design is completed based on ATF beam line condition. The design and layout are presented. All the optical devices are acquired and machined. Installation and alignment have been done a few times for testing. (Abstract shortened by UMI.)

  2. Outline for a Spheromak Proof of Principle Experiment

    NASA Astrophysics Data System (ADS)

    Woodruff, Simon; Macnab, Angus

    2007-11-01

    A possible means for reducing reactor core complexity and size (and hence cost) could lie with research into the Spheromak concept: a plasma ring with no coils linking the plasma. Much progress has been made in the last 20 years, and now tokamak-like confinement is being reported, with work focusing on understanding beta-limits, transport and novel means of generating magnetic fields both in sustained and pulsed scenarios. Spheromak research is maturing, with many experiments integrated into a national program to resolve well defined critical physics issues. This poster summarizes the work from the last 20 years both as a historical overview and an outline of the present status. A natural consequence is to suggest the possibility of a Next-Step Spheromak, or advanced Proof of Principle device that will build on recent success and address many of the remaining critical issues in preparation for a Spheromak BPX.

  3. Proof-of-Principle Dermal Decontamination Experiments: Swine Skin

    DTIC Science & Technology

    2007-04-01

    approvals it was decided to first demonstrate the proof-of-principle of dermal decontamination for this model using swine skin samples ex vivo . When...appropriate individual protection equipment (IPE) and dosimetry . 3. All activities were monitored by the DRDC Ottawa RadSO. 4. The workstation...while working with the radionuclides, as well as the necessary dosimetry . All personnel wore standard Health Canada issued thermo- luminescent

  4. Development of a Single-Pass Amplifier for an Optical Stochastic Cooling Proof-of-Principle Experiment at Fermilab's IOTA Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Andorf, M. B.; Lebedev, V. A.; Piot, P.

    2015-06-01

    Optical stochastic cooling (OSC) is a method of beam cooling which is expected to provide cooling rates orders of magnitude larger than ordinary stochastic cooling. Light from an undulator (the pickup) is amplified and fed back onto the particle beam via another undulator (the kicker). Fermilab is currently exploring a possible proof-of-principle experiment of the OSC at the integrable-optics test accelerator (IOTA) ring. To implement effective OSC a good correction of phase distortions in the entire band of the optical amplifier is required. In this contribution we present progress in experimental characterization of phase distortions associated to a Titanium Sapphiremore » crystal laser-gain medium (a possible candidate gain medium for the OSC experiment to be performed at IOTA). We also discuss a possible option for a mid-IR amplifier« less

  5. Proof-of-principle Experiment of a Ferroelectric Tuner for the 1.3 GHz Cavity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Choi,E.M.; Hahn, H.; Shchelkunov, S. V.

    2009-01-01

    A novel tuner has been developed by the Omega-P company to achieve fast control of the accelerator RF cavity frequency. The tuner is based on the ferroelectric property which has a variable dielectric constant as function of applied voltage. Tests using a Brookhaven National Laboratory (BNL) 1.3 GHz electron gun cavity have been carried out for a proof-of-principle experiment of the ferroelectric tuner. Two different methods were used to determine the frequency change achieved with the ferroelectric tuner (FT). The first method is based on a S11 measurement at the tuner port to find the reactive impedance change when themore » voltage is applied. The reactive impedance change then is used to estimate the cavity frequency shift. The second method is a direct S21 measurement of the frequency shift in the cavity with the tuner connected. The estimated frequency change from the reactive impedance measurement due to 5 kV is in the range between 3.2 kHz and 14 kHz, while 9 kHz is the result from the direct measurement. The two methods are in reasonable agreement. The detail description of the experiment and the analysis are discussed in the paper.« less

  6. Ultra-high gradient channeling acceleration in nanostructures: Design/progress of proof-of-concept (POC) experiments

    NASA Astrophysics Data System (ADS)

    Shin, Y. M.; Green, A.; Lumpkin, A. H.; Thurman-Keup, R. M.; Shiltsev, V.; Zhang, X.; Farinella, D. M.-A.; Taborek, P.; Tajima, T.; Wheeler, J. A.; Mourou, G.

    2017-03-01

    A short bunch of relativistic particles, or a short-pulse laser, perturb the density state of conduction electrons in a solid crystal and excite wakefields along atomic lattices in a crystal. Under a coupling condition between a driver and plasma, the wakes, if excited, can accelerate channeling particles with TeV/m acceleration gradients [1], in principle, since the density of charge carriers (conduction electrons) in solids n0 = 1020 - 1023 cm-3 is significantly higher than what was considered above in gaseous plasma. Nanostructures have some advantages over crystals for channeling applications of high power beams. The de-channeling rate can be reduced and the beam acceptance increased by the large size of the channels. For beam-driven acceleration, a bunch length with a sufficient charge density would need to be in the range of the plasma wavelength to properly excite plasma wakefields, and channeled particle acceleration with the wakefields must occur before the ions in the lattices move beyond the restoring threshold. In the case of the excitation by short laser pulses, the dephasing length is appreciably increased with the larger channel, which enables channeled particles to gain sufficient amounts of energy. This paper describes simulation analyses on beam- and laser (X-ray)-driven accelerations in effective nanotube models obtained from the Vsim and EPOCH codes. Experimental setups to detect wakefields are also outlined with accelerator facilities at Fermilab and Northern Illinois University (NIU). In the FAST facility, the electron beamline was successfully commissioned at 50 MeV, and it is being upgraded toward higher energies for electron accelerator R&D. The 50 MeV injector beamline of the facility is used for X-ray crystal-channeling radiation with a diamond target. It has been proposed to utilize the same diamond crystal for a channeling acceleration proof-of-concept (POC). Another POC experiment is also designed for the NIU accelerator lab with time

  7. Soft magnetic tweezers: a proof of principle.

    PubMed

    Mosconi, Francesco; Allemand, Jean François; Croquette, Vincent

    2011-03-01

    We present here the principle of soft magnetic tweezers which improve the traditional magnetic tweezers allowing the simultaneous application and measurement of an arbitrary torque to a deoxyribonucleic acid (DNA) molecule. They take advantage of a nonlinear coupling regime that appears when a fast rotating magnetic field is applied to a superparamagnetic bead immersed in a viscous fluid. In this work, we present the development of the technique and we compare it with other techniques capable of measuring the torque applied to the DNA molecule. In this proof of principle, we use standard electromagnets to achieve our experiments. Despite technical difficulties related to the present implementation of these electromagnets, the agreement of measurements with previous experiments is remarkable. Finally, we propose a simple way to modify the experimental design of electromagnets that should bring the performances of the device to a competitive level.

  8. A proof of principle spheromak experiment: The next step on a recently opened path to economical fusion power

    NASA Astrophysics Data System (ADS)

    Jarboe, Thomas; Marklin, George; Nelson, Brian; Sutherland, Derek; HIT Team Team

    2013-10-01

    A proof of principle experiment to study closed-flux energy confinement of a spheromak sustained by imposed dynamo current drive is described. A two-fluid validated NIMROD code has simulated closed-flux sustainment on a stable spheromak using imposed dynamo current drive (IDCD), demonstrating that dynamo current drive is compatible with closed flux. (submitted for publication and see adjacent poster.(spsap)) HIT-SI, a = 0.25 m, has achieved 90 kA of toroidal current, current gains of nearly 4, and operation from 5.5 kHz to 68 kHz, demonstrating the robustness of the method.(spsap) Finally, a reactor design study using fusion technology developed for ITER and modern nuclear technology shows a design that is economically superior to coal.(spsap) The spheromak reactor and development path are about a factor of 10 less expensive than that of the tokamak/stellarator. These exciting results justify a proof of principle (PoP) confinement experiment of a spheromak sustained by IDCD. Such an experiment (R = 1.5 m, a = 1 m, Itor = 3 . 2 MA, n = 4e19/m3, T = 3 keV) is described in detail.

  9. Proof-of-principle experiment of reference-frame-independent quantum key distribution with phase coding

    PubMed Central

    Liang, Wen-Ye; Wang, Shuang; Li, Hong-Wei; Yin, Zhen-Qiang; Chen, Wei; Yao, Yao; Huang, Jing-Zheng; Guo, Guang-Can; Han, Zheng-Fu

    2014-01-01

    We have demonstrated a proof-of-principle experiment of reference-frame-independent phase coding quantum key distribution (RFI-QKD) over an 80-km optical fiber. After considering the finite-key bound, we still achieve a distance of 50 km. In this scenario, the phases of the basis states are related by a slowly time-varying transformation. Furthermore, we developed and realized a new decoy state method for RFI-QKD systems with weak coherent sources to counteract the photon-number-splitting attack. With the help of a reference-frame-independent protocol and a Michelson interferometer with Faraday rotator mirrors, our system is rendered immune to the slow phase changes of the interferometer and the polarization disturbances of the channel, making the procedure very robust. PMID:24402550

  10. Simulation prediction and experiment setup of vacuum laser acceleration at Brookhaven National Lab-Accelerator Test Facility

    NASA Astrophysics Data System (ADS)

    Shao, L.; Cline, D.; Ding, X.; Ho, Y. K.; Kong, Q.; Xu, J. J.; Pogorelsky, I.; Yakimenko, V.; Kusche, K.

    2013-02-01

    This paper presents the pre-experiment plan and prediction of the first stage of vacuum laser acceleration (VLA) collaborating by UCLA, Fudan University and ATF-BNL. This first stage experiment is a proof-of-principle to support our previously posted novel VLA theory. Simulations show that based on ATF's current experimental conditions the electron beam with initial energy of 15 MeV can get net energy gain from an intense CO2 laser beam. The difference in electron beam energy spread is observable by the ATF beam line diagnostics system. Further, this energy spread expansion effect increases along with an increase in laser intensity. The proposal has been approved by the ATF committee and the experiment will be our next project.

  11. Autonomous intelligent cars: proof that the EPSRC Principles are future-proof

    NASA Astrophysics Data System (ADS)

    de Cock Buning, Madeleine; de Bruin, Roeland

    2017-07-01

    Principle 2 of the EPSRC's principles of robotics (AISB workshop on Principles of Robotics, 2016) proves to be future proof when applied to the current state of the art of law and technology surrounding autonomous intelligent cars (AICs). Humans, not AICS, are responsible agents. AICs should be designed; operated as far as is practicable to comply with existing laws and fundamental rights and freedoms, including privacy by design. It will show that some legal questions arising from autonomous intelligent driving technology can be answered by the technology itself.

  12. A new proof-of-principle contraband detection system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sredniawski, J.J.; Debiak, T.; Kamykowski, E.

    1995-12-01

    A new concept for a CDS has been developed under a Phase I ARPA funded program; it uses gamma resonance absorption (GRA) to detect certain illegal drugs that may be transported in man-portable containers. A high detection probability for heroin and cocaine is possible with a device that is also searching for explosives. Elemental detection of both N and Cl is utilized, and with tomography, a 3D density image of the elements is generated. Total density image is also developed. These two together may be used with considerable confidence in determining if heroin or cocaine is present in the interrogatedmore » containers in a small quantity (1 kg). The CDS employs a high current ({ge}10 mA) DC accelerator that produces a beam of 1.75 or 1.89 MeV protons. These protons impact a target with coatings of {sup 13}C and {sup 34}S. Depending on the coating, the resultant resonant gamma rays are preferentially absorbed in either {sup 14}N or {sup 35}Cl. The resonant gammas come off the target in a conical fan at 80.7{degree} for N and 82{degree} for Cl; a common array of segmented BGO detectors is used over an arc of 53{degree} to provide input to an imaging subsystem. The tomography makes use of rotation and vertical translation of a baggage carousel holding typically 18 average sized bags for batch processing of the contents. The single proton accelerator and target can supply multiple detection stations with the appropriate gammas, a feature that may lead to very high throughput potential approaching 2000 bags/hr. Each detection station can operate somewhat independently from the others. This paper presents the overall requirements, design, operating principles, and characteristics of the CDS proof-of-principle device developed in the Phase I program.« less

  13. Proof-of-principle contraband detection system for nonintrusive inspection

    NASA Astrophysics Data System (ADS)

    Sredniawski, Joseph J.; Debiak, T.; Kamykowski, E.; Rathke, John E.; Schmor, P.; Milton, Bill; Stanford, G.; Rogers, Joel; Boyd, J.; Brondo, J.

    1997-02-01

    A proof-of-principle (POP) contraband detection system (CDS), is under construction at Northrop Grumman's Advanced Technology and Development Center. We employ gamma resonance absorption to detect nitrogen or chlorine in explosives and certain forms of illegal drugs. Using tomography, 3D images of the total density and selected element density are generated. These characteristics together may be utilized with considerable confidence in determining if contraband is present in baggage or cargo. The CDS employs a high current DC electrostatic accelerator that provides a beam of proton sat either 1.75 or 1.89 MeV. These high energy particles impinge upon a target coated with 13C or 34S. The resultant resonant gamma rays are preferentially absorbed in either 14N or 35Cl. Because of the penetrating power of the gamma rays, this approach can be utilized for inspection of fully loaded aircraft containers such as the LD3. With proper design for handling baggage and with certain CDS design features not present in the POP, throughputs approaching 2000 bags/hour are estimated. Furthermore, the technology being developed for the CDS accelerator may have other applications such as for Boron Neutron Capture Therapy or Neutron Radiography. Our current program calls for testing of the POP CDS by late 1996. This paper presents the overall design, and characteristics of the CDS POP and the status of the program.

  14. The Study of Advanced Accelerator Physics Research at UCLA Using the ATF at BNL: Vacuum Acceleration by Laser of Free Electrons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cline, David B.

    An experiment was designed and data were taken to demonstrate that a tightly focused laser on vacuum can accelerate an electron beam in free space. The experiment was proof-of-principle and showed a clear effect for the laser beam off and on. The size of the effect was about 20% and was consistent over 30 laser and beam shots.

  15. Ultra-High Gradient Channeling Acceleration in Nanostructures: Design/Progress of Proof-of-Concept (POC) Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shin, Young Min; Green, A.; Lumpkin, A. H.

    2016-09-16

    A short bunch of relativistic particles or a short-pulse laser perturbs the density state of conduction electrons in a solid crystal and excites wakefields along atomic lattices in a crystal. Under a coupling condition the wakes, if excited, can accelerate channeling particles with TeV/m acceleration gradients in principle since the density of charge carriers (conduction electrons) in solids n 0 = ~ 10 20 – 10 23 cm -3 is significantly higher than what can be obtained in gaseous plasma. Nanostructures have some advantages over crystals for channeling applications of high power beams. The dechanneling rate can be reduced andmore » the beam acceptance increased by the large size of the channels. For beam-driven acceleration, a bunch length with a sufficient charge density would need to be in the range of the plasma wavelength to properly excite plasma wakefields, and channeled particle acceleration with the wakefields must occur before the ions in the lattices move beyond the restoring threshold. In the case of the excitation by short laser pulses, the dephasing length is appreciably increased with the larger channel, which enables channeled particles to gain sufficient amounts of energy. This paper describes simulation analyses on beam- and laser (X-ray)-driven accelerations in effective nanotube models obtained from Vsim and EPOCH codes. Experimental setups to detect wakefields are also outlined with accelerator facilities at Fermilab and NIU. In the FAST facility, the electron beamline was successfully commissioned at 50 MeV and it is being upgraded toward higher energies for electron accelerator R&D. The 50 MeV injector beamline of the facility is used for X-ray crystal-channeling radiation with a diamond target. It has been proposed to utilize the same diamond crystal for a channeling acceleration POC test. Another POC experiment is also designed for the NIU accelerator lab with time-resolved electron diffraction. Recently, a stable generation of single

  16. First staging of two laser accelerators.

    PubMed

    Kimura, W D; van Steenbergen, A; Babzien, M; Ben-Zvi, I; Campbell, L P; Cline, D B; Dilley, C E; Gallardo, J C; Gottschalk, S C; He, P; Kusche, K P; Liu, Y; Pantell, R H; Pogorelsky, I V; Quimby, D C; Skaritka, J; Steinhauer, L C; Yakimenko, V

    2001-04-30

    Staging of two laser-driven, relativistic electron accelerators has been demonstrated for the first time in a proof-of-principle experiment, whereby two distinct and serial laser accelerators acted on an electron beam in a coherently cumulative manner. Output from a CO2 laser was split into two beams to drive two inverse free electron lasers (IFEL) separated by 2.3 m. The first IFEL served to bunch the electrons into approximately 3 fs microbunches, which were rephased with the laser wave in the second IFEL. This represents a crucial step towards the development of practical laser-driven electron accelerators.

  17. A restricted proof that the weak equivalence principle implies the Einstein equivalence principle

    NASA Technical Reports Server (NTRS)

    Lightman, A. P.; Lee, D. L.

    1973-01-01

    Schiff has conjectured that the weak equivalence principle (WEP) implies the Einstein equivalence principle (EEP). A proof is presented of Schiff's conjecture, restricted to: (1) test bodies made of electromagnetically interacting point particles, that fall from rest in a static, spherically symmetric gravitational field; (2) theories of gravity within a certain broad class - a class that includes almost all complete relativistic theories that have been found in the literature, but with each theory truncated to contain only point particles plus electromagnetic and gravitational fields. The proof shows that every nonmentric theory in the class (every theory that violates EEP) must violate WEP. A formula is derived for the magnitude of the violation. It is shown that WEP is a powerful theoretical and experimental tool for constraining the manner in which gravity couples to electromagnetism in gravitation theories.

  18. Organoid Center Strategies for Accelerating Clinical Translation.

    PubMed

    Takebe, Takanori; Wells, James M; Helmrath, Michael A; Zorn, Aaron M

    2018-06-01

    The meteoric rise in stem-cell-derived organoid technologies has ushered in a new era of "organoid medicine." Here we discuss how an organoid center can accelerate the translation of laboratory proof-of-principle experiments into clinical practice by developing and utilizing shared platforms for commercial and medical applications. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Principles of Induction Accelerators

    NASA Astrophysics Data System (ADS)

    Briggs*, Richard J.

    The basic concepts involved in induction accelerators are introduced in this chapter. The objective is to provide a foundation for the more detailed coverage of key technology elements and specific applications in the following chapters. A wide variety of induction accelerators are discussed in the following chapters, from the high current linear electron accelerator configurations that have been the main focus of the original developments, to circular configurations like the ion synchrotrons that are the subject of more recent research. The main focus in the present chapter is on the induction module containing the magnetic core that plays the role of a transformer in coupling the pulsed power from the modulator to the charged particle beam. This is the essential common element in all these induction accelerators, and an understanding of the basic processes involved in its operation is the main objective of this chapter. (See [1] for a useful and complementary presentation of the basic principles in induction linacs.)

  20. Preparing for Formal Proofs in Geometry

    ERIC Educational Resources Information Center

    Johnson, Art

    2009-01-01

    One way in which geometry teachers can help students develop their reasoning is by providing proof-readiness experiences. Blum and Kirsch (1991) suggest that "preformal proofs" can help students develop deductive reasoning. Preformal proofs, which follow the basic principles of deductive reasoning, can help prepare students for formal deduction in…

  1. Polarized fusion, its implications, and plans for a proof-of-principle experiment at the DIII-D tokamak

    NASA Astrophysics Data System (ADS)

    Sandorfi, A. M.; Deur, A.; Lowry, M. M.; Wei, X.; Pace, D.; Eidietis, N.; Hyatt, A.; Jackson, G. L.; Lanctot, M.; Smith, S.; St-John, H.; Miller, G. W.; Zheng, X.; Baylor, L. R.

    2015-10-01

    The cross section for the primary fusion reaction in a tokamak, D+t --> α +n, would increase by a factor of 1.5 if the fuels were spin polarized parallel to the local field, rather than randomly oriented. Simulations show further gains in reaction rate would accompany this increase in large-scale machines such as ITER, due to increased alpha heating. The potential realization of such benefits rests on the crucial question of the survival of spin polarization for periods comparable to the energy containment time. Despite encouraging calculations, technical challenges in preparing and handling polarized materials have prevented any direct tests. Advances in three areas - polarized material technologies developed for nuclear and particle physics as well as medical imaging, polymer pellets developed for Inertial Confinement, and cryogenic injection guns developed for fueling tokamaks - have matured to the point where a direct in situ measurement is possible using the mirror reaction, D+3He --> α +p. Designs and simulations of a proof-of-principle experiment at the DIII-D tokamak in San Diego will be discussed. Work carried out under US DOE Contract DE-AC05-06OR23177 supporting Jefferson Lab and General Atomics Internal R&D funding.

  2. A preliminary study of a cryogenic equivalence principle experiment on Shuttle

    NASA Technical Reports Server (NTRS)

    Everitt, C. W. F.; Worden, P. W., Jr.

    1985-01-01

    The Weak Equivalence Principle is the hypothesis that all test bodies fall with the same acceleration in the same gravitational field. The current limit on violations of the Weak Equivalence Principle, measured by the ratio of the difference in acceleration of two test masses to their average acceleration, is about 3 parts in one-hundred billion. It is anticipated that this can be improved in a shuttle experiment to a part in one quadrillion. Topics covered include: (1) studies of the shuttle environment, including interference with the experiment, interfacing to the experiment, and possible alternatives; (2) numerical simulations of the proposed experiment, including analytic solutions for special cases of the mass motion and preliminary estimates of sensitivity and time required; (3) error analysis of several noise sources such as thermal distortion, gas and radiation pressure effects, and mechanical distortion; and (4) development and performance tests of a laboratory version of the instrument.

  3. Proof-of-principle demonstration of Nb3Sn superconducting radiofrequency cavities for high Q0 applications

    NASA Astrophysics Data System (ADS)

    Posen, S.; Liepe, M.; Hall, D. L.

    2015-02-01

    Many future particle accelerators require hundreds of superconducting radiofrequency (SRF) cavities operating with high duty factor. The large dynamic heat load of the cavities causes the cryogenic plant to make up a significant part of the overall cost of the facility. This contribution can be reduced by replacing standard niobium cavities with ones coated with a low-dissipation superconductor such as Nb3Sn. In this paper, we present results for single cell cavities coated with Nb3Sn at Cornell. Five coatings were carried out, showing that at 4.2 K, high Q0 out to medium fields was reproducible, resulting in an average quench field of 14 MV/m and an average 4.2 K Q0 at quench of 8 × 109. In each case, the peak surface magnetic field at quench was well above Hc1, showing that it is not a limiting field in these cavities. The coating with the best performance had a quench field of 17 MV/m, exceeding gradient requirements for state-of-the-art high duty factor SRF accelerators. It is also shown that—taking into account the thermodynamic efficiency of the cryogenic plant—the 4.2 K Q0 values obtained meet the AC power consumption requirements of state-of-the-art high duty factor accelerators, making this a proof-of-principle demonstration for Nb3Sn cavities in future applications.

  4. Test of the Equivalence Principle in an Einstein Elevator

    NASA Technical Reports Server (NTRS)

    Shapiro, Irwin I.

    2002-01-01

    The scientific goal of the experiment is to test the equality of gravitational and inertial mass (i.e., to test the Principle of Equivalence) by measuring the independence of the rate of fall of bodies from the composition of the falling body. The measurement is accomplished by measuring the relative displacement (or equivalently acceleration) of two falling bodies of different materials which are the proof masses of a differential accelerometer. The goal of the experiment is to measure the Eotvos ratio delta-g/g (differential acceleration/common acceleration) with an accuracy goal of a few parts in 10(exp 15). The estimated accuracy is about two orders of magnitude better than the present state of the art. The experiment is a null experiment in which a result different from zero will indicate a violation of the Equivalence Principle. The main goal of the study to be carried out under this grant is the flight definition of the experiment and bread boarding of critical components of the experiment that will enable us to be ready for the following phases of the project. The project involves an international cooperation in which the responsibility of the US side is the flight definition of the experimental facility while the responsibility of the non-US partners is the flight definition and laboratory prototyping of the differential acceleration detector. In summary, the experiment to be designed is for taking differential acceleration measurements with a high-sensitivity detector (the sensor) during free fall conditions lasting up to 30 s in a disturbance-free acceleration environment. The experiment strategy consists in letting the sensor free fall inside a few meters long (in the vertical direction) evacuated capsule that is falling simultaneously in the rarefied atmosphere after release from a helium balloon flying at a stratospheric altitude.

  5. Lagrange Multipliers, Adjoint Equations, the Pontryagin Maximum Principle and Heuristic Proofs

    ERIC Educational Resources Information Center

    Ollerton, Richard L.

    2013-01-01

    Deeper understanding of important mathematical concepts by students may be promoted through the (initial) use of heuristic proofs, especially when the concepts are also related back to previously encountered mathematical ideas or tools. The approach is illustrated by use of the Pontryagin maximum principle which is then illuminated by reference to…

  6. Tritium proof-of-principle pellet injector: Phase 2

    NASA Astrophysics Data System (ADS)

    Fisher, P. W.; Gouge, M. J.

    1995-03-01

    As part of the International Thermonuclear Engineering Reactor (ITER) plasma fueling development program, Oak Ridge National Laboratory (ORNL) has fabricated a pellet injection system to test the mechanical and thermal properties of extruded tritium. This repeating, single-stage, pneumatic injector, called the Tritium-Proof-of-Principle Phase-2 (TPOP-2) Pellet Injector, has a piston-driven mechanical extruder and is designed to extrude hydrogenic pellets sized for the ITER device. The TPOP-II program has the following development goals: evaluate the feasibility of extruding tritium and DT mixtures for use in future pellet injection systems; determine the mechanical and thermal properties of tritium and DT extrusions; integrate, test and evaluate the extruder in a repeating, single-stage light gas gun sized for the ITER application (pellet diameter approximately 7-8 mm); evaluate options for recycling propellant and extruder exhaust gas; evaluate operability and reliability of ITER prototypical fueling systems in an environment of significant tritium inventory requiring secondary and room containment systems. In initial tests with deuterium feed at ORNL, up to thirteen pellets have been extruded at rates up to 1 Hz and accelerated to speeds of order 1.0-1.1 km/s using hydrogen propellant gas at a supply pressure of 65 bar. The pellets are typically 7.4 mm in diameter and up to 11 mm in length and are the largest cryogenic pellets produced by the fusion program to date. These pellets represent about a 11% density perturbation to ITER. Hydrogenic pellets will be used in ITER to sustain the fusion power in the plasma core and may be crucial in reducing first wall tritium inventories by a process called isotopic fueling where tritium-rich pellets fuel the burning plasma core and deuterium gas fuels the edge.

  7. Proof-of-principle demonstration of Nb 3Sn superconducting radiofrequency cavities for high Q 0 applications

    DOE PAGES

    Posen, S.; Liepe, M.; Hall, D. L.

    2015-02-23

    Many future particle accelerators require hundreds of superconducting radiofrequency (SRF) cavities operating with high duty factor. The large dynamic heat load of the cavities causes the cryogenic plant to make up a significant part of the overall cost of the facility. Our contribution can be reduced by replacing standard niobium cavities with ones coated with a low-dissipation superconductor such as Nb 3Sn. Here, we present results for single cell cavities coated with Nb 3Sn at Cornell. Five coatings were carried out, showing that at 4.2 K, high Q 0 out to medium fields was reproducible, resulting in an average quenchmore » field of 14 MV/m and an average 4.2 K Q 0 at quench of 8 x 10 9 . In each case, the peak surface magnetic field at quench was well above H c1, showing that it is not a limiting field in these cavities. Furthermore, the coating with the best performance had a quench field of 17 MV/m, exceeding gradient requirements for state-of-the-art high duty factor SRF accelerators. It is also shown that—taking into account the thermodynamic efficiency of the cryogenic plant—the 4.2 K Q 0 values obtained meet the AC power consumption requirements of state-of-the-art high duty factor accelerators, making this a proof-of-principle demonstration for Nb 3Sn cavities in future applications.« less

  8. Microfluidic 68Ga-labeling: a proof of principle study.

    PubMed

    Pfaff, Sarah; Philippe, Cecile; Pichler, Verena; Hacker, Marcus; Mitterhauser, Markus; Wadsak, Wolfgang

    2018-05-01

    Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is a popular PET nuclide due to its favorable characteristics, like advantageous half-life (68 min) and independency of a cyclotron on-site for its production. Accordingly, several 68Ga-complexes for cancer imaging via PET have been made available during the last few years. In this work, 68Ga-labeled compounds were synthesized applying a commercially available microfluidic device for the first time. Therefore, a proof of principle study using three important radiotracers, [68Ga]Ga-PSMA-11, [68Ga]Ga-NODAGA-RGDyk and [68Ga]Ga-DOTA-NOC, was designed. For all three radioligands, various synthesis parameters were evaluated and the feasibility of using a continuous flow reactor was assessed. All of the precursors were successfully radiolabeled with a radiochemical yield higher than 80%, proving the principle that a microfluidic set-up is a suitable approach for the production of 68Ga-labeled tracers.

  9. Proofs without Words: A Visual Application of Reasoning and Proof

    ERIC Educational Resources Information Center

    Bell, Carol J.

    2011-01-01

    Reasoning and Proof is one of the Process Standards set forth in National Council of Teachers of Mathematics' (NCTM) "Principles and Standards for School Mathematics." Thus, it is important to give students opportunities to build their reasoning skills and aid their understanding of the proof process. Teaching students how to do proofs is a…

  10. Discrimination Training Reduces High Rate Social Approach Behaviors in Angelman Syndrome: Proof of Principle

    ERIC Educational Resources Information Center

    Heald, M.; Allen, D.; Villa, D.; Oliver, C.

    2013-01-01

    This proof of principle study was designed to evaluate whether excessively high rates of social approach behaviors in children with Angelman syndrome (AS) can be modified using a multiple schedule design. Four children with AS were exposed to a multiple schedule arrangement, in which social reinforcement and extinction, cued using a novel…

  11. Cyclotron autoresonant accelerator for electron beam dry scrubbing of flue gases

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaPointe, M. A.; Hirshfield, J. L.; Department of Physics, Yale University, P.O. Box 208124, New Haven, Connecticut 06520-8124

    1999-06-10

    Design and construction is underway for a novel rf electron accelerator for electron beam dry scrubbing (EBDS) of flue gases emanating from fossil-fuel burners. This machine, a cyclotron autoresonance accelerator (CARA), has already shown itself capable of converting rf power to electron beam power with efficiency values as high as 96%. This proof-of-principle experiment will utilize a 300 kV, 33 A Pierce type electron gun and up to 24 MW of available rf power at 2.856 GHz to produce 1.0 MeV, 33 MW electron beam pulses. The self-scanning conical beam from the high power CARA will be evaluated for EBDSmore » and other possible environmental applications.« less

  12. Proof of principle for epitope-focused vaccine design

    PubMed Central

    Correia, Bruno E.; Bates, John T.; Loomis, Rebecca J.; Baneyx, Gretchen; Carrico, Christopher; Jardine, Joseph G.; Rupert, Peter; Correnti, Colin; Kalyuzhniy, Oleksandr; Vittal, Vinayak; Connell, Mary J.; Stevens, Eric; Schroeter, Alexandria; Chen, Man; MacPherson, Skye; Serra, Andreia M.; Adachi, Yumiko; Holmes, Margaret A.; Li, Yuxing; Klevit, Rachel E.; Graham, Barney S.; Wyatt, Richard T.; Baker, David; Strong, Roland K.; Crowe, James E.; Johnson, Philip R.; Schief, William R.

    2014-01-01

    Summary Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Multiple major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antibodies have been identified for several such cases. Hence, new vaccine design methods to induce epitope-specific neutralizing antibodies are needed. Here we show, with a neutralization epitope from respiratory syncytial virus (RSV), that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies. These scaffolds represent promising leads for research and development of a human RSV vaccine needed to protect infants, young children and the elderly. More generally, the results provide proof of principle for epitope-focused and scaffold-based vaccine design, and encourage the evaluation and further development of these strategies for a variety of other vaccine targets including antigenically highly variable pathogens such as HIV and influenza. PMID:24499818

  13. Proof of principle for epitope-focused vaccine design

    NASA Astrophysics Data System (ADS)

    Correia, Bruno E.; Bates, John T.; Loomis, Rebecca J.; Baneyx, Gretchen; Carrico, Chris; Jardine, Joseph G.; Rupert, Peter; Correnti, Colin; Kalyuzhniy, Oleksandr; Vittal, Vinayak; Connell, Mary J.; Stevens, Eric; Schroeter, Alexandria; Chen, Man; MacPherson, Skye; Serra, Andreia M.; Adachi, Yumiko; Holmes, Margaret A.; Li, Yuxing; Klevit, Rachel E.; Graham, Barney S.; Wyatt, Richard T.; Baker, David; Strong, Roland K.; Crowe, James E.; Johnson, Philip R.; Schief, William R.

    2014-03-01

    Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antibodies have been identified for several such cases. Hence, new vaccine design methods to induce epitope-specific neutralizing antibodies are needed. Here we show, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies. These scaffolds represent promising leads for the research and development of a human respiratory syncytial virus vaccine needed to protect infants, young children and the elderly. More generally, the results provide proof of principle for epitope-focused and scaffold-based vaccine design, and encourage the evaluation and further development of these strategies for a variety of other vaccine targets, including antigenically highly variable pathogens such as human immunodeficiency virus and influenza.

  14. Novel optical gyroscope: proof of principle demonstration and future scope

    PubMed Central

    Srivastava, Shailesh; Rao D. S., Shreesha; Nandakumar, Hari

    2016-01-01

    We report the first proof-of-principle demonstration of the resonant optical gyroscope with reflector that we have recently proposed. The device is very different from traditional optical gyroscopes since it uses the inherent coupling between the clockwise and counterclockwise propagating waves to sense the rotation. Our demonstration confirms our theoretical analysis and simulations. We also demonstrate a novel method of biasing the gyroscope using orthogonal polarization states. The simplicity of the structure and the readout method, the theoretically predicted high sensitivities (better than 0.001 deg/hr), and the possibility of further performance enhancement using a related laser based active device, all have immense potential for attracting fresh research and technological initiatives. PMID:27694987

  15. Test of the Equivalence Principle in an Einstein Elevator

    NASA Technical Reports Server (NTRS)

    Shapiro, Irwin I.; Glashow, S.; Lorenzini, E. C.; Cosmo, M. L.; Cheimets, P.; Finkelstein, N.; Schneps, M.

    2004-01-01

    The scientific goal of the experiment is to test the equality of gravitational and inertial mass (i.e., to test the Principle of Equivalence) by measuring the independence of the rate of fall of bodies from the composition of the falling body. The measurement is accomplished by measuring the relative displacement (or equivalently acceleration) of two falling bodies of different materials which are the proof masses of a differential accelerometer. The goal of the experiment is to measure the Eoetvoes ratio sigma g/g (differential acceleration/common acceleration) with an accuracy goal of several parts in 10(exp 15). The estimated accuracy is about two orders of magnitude better than the present state of the art. The main goal of the study to be carried out under this grant is part of the flight definition of the experiment and laboratory testing of key components. The project involves an international cooperation in which the responsibility of the US side is the flight definition of the experimental facility while the responsibility of the non-US partners is the flight definition and laboratory prototyping of the differential acceleration detector.In summary, the experiment to be designed is for taking differential acceleration measurements with a high-sensitivity detector (the sensor) during free fall conditions lasting up to 30 s in a disturbance-free acceleration environment. The experiment strategy consists in letting the sensor free fall inside a few meters long (in the vertical direction) evacuated capsule that is falling simultaneously in the rarefied atmosphere after release from a helium balloon flying at a stratospheric altitude.

  16. Test of the Equivalence Principle in an Einstein Elevator

    NASA Technical Reports Server (NTRS)

    Shapiro, Irwin I.; Glashow, S.; Lorenzini, E. C.; Cosmo, M. L.; Cheimets, P. N.; Finkelstein, N.; Schneps, M.

    2004-01-01

    The scientific goal of the experiment is to test the equality of gravitational and inertial mass (i.e., to test the Principle of Equivalence) by measuring the independence of the rate of fall of bodies from their compositions. The measurement is accomplished by measuring the relative displacement (or equivalently acceleration) of two falling bodies of different materials which are the proof masses of a differential accelerometer spinning about an horizontal axis to modulate a possible violation signal. A non-zero differential acceleration appearing at the signal frequency will indicate a violation of the Equivalence Principle. The goal of the experiment is to measure the Eotvos ratio og/g (differential acceleration/common acceleration) with a targeted accuracy that is about two orders of magnitude better than the state of the art (presently at several parts in 10(exp 13). The analyses carried out during this first grant year have focused on: (1) evaluation of possible shapes for the proof masses to meet the requirements on the higher-order mass moment disturbances generated by the falling capsule; (2) dynamics of the instrument package and differential acceleration measurement in the presence of errors and imperfections; (3) computation of the inertia characteristic of the instrument package that enable a separation of the signal from the dynamics-related noise; (4) a revised thermal analysis of the instrument package in light of the new conceptual design of the cryostat; (5) the development of a dynamic and control model of the capsule attached to the gondola and balloon to define the requirements for the leveling mechanism (6) a conceptual design of the leveling mechanism that keeps the capsule aligned before release from the balloon; and (7) a new conceptual design of the customized cryostat and a preliminary valuation of its cost. The project also involves an international cooperation with the Institute of Space Physics (IFSI) in Rome, Italy. The group at IFSI

  17. A New Type of Plasma Wakefield Accelerator Driven By Magnetowaves

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Pisin; /KIPAC, Menlo Park /Taiwan, Natl. Taiwan U.; Chang, Feng-Yin

    2011-09-12

    We present a new concept for a plasma wakefield accelerator driven by magnetowaves (MPWA). This concept was originally proposed as a viable mechanism for the 'cosmic accelerator' that would accelerate cosmic particles to ultra-high energies in the astrophysical setting. Unlike the more familiar plasma wakefield accelerator (PWFA) and the laser wakefield accelerator (LWFA) where the drivers, the charged-particle beam and the laser, are independently existing entities, MPWA invokes the high-frequency and high-speed whistler mode as the driver, which is a medium wave that cannot exist outside of the plasma. Aside from the difference in drivers, the underlying mechanism that excitesmore » the plasma wakefield via the ponderomotive potential is common. Our computer simulations show that under appropriate conditions, the plasma wakefield maintains very high coherence and can sustain high-gradient acceleration over many plasma wavelengths. We suggest that in addition to its celestial application, the MPWA concept can also be of terrestrial utility. A proof-of-principle experiment on MPWA would benefit both terrestrial and celestial accelerator concepts.« less

  18. Guided post-acceleration of laser-driven ions by a miniature modular structure

    PubMed Central

    Kar, Satyabrata; Ahmed, Hamad; Prasad, Rajendra; Cerchez, Mirela; Brauckmann, Stephanie; Aurand, Bastian; Cantono, Giada; Hadjisolomou, Prokopis; Lewis, Ciaran L. S.; Macchi, Andrea; Nersisyan, Gagik; Robinson, Alexander P. L.; Schroer, Anna M.; Swantusch, Marco; Zepf, Matt; Willi, Oswald; Borghesi, Marco

    2016-01-01

    All-optical approaches to particle acceleration are currently attracting a significant research effort internationally. Although characterized by exceptional transverse and longitudinal emittance, laser-driven ion beams currently have limitations in terms of peak ion energy, bandwidth of the energy spectrum and beam divergence. Here we introduce the concept of a versatile, miniature linear accelerating module, which, by employing laser-excited electromagnetic pulses directed along a helical path surrounding the laser-accelerated ion beams, addresses these shortcomings simultaneously. In a proof-of-principle experiment on a university-scale system, we demonstrate post-acceleration of laser-driven protons from a flat foil at a rate of 0.5 GeV m−1, already beyond what can be sustained by conventional accelerator technologies, with dynamic beam collimation and energy selection. These results open up new opportunities for the development of extremely compact and cost-effective ion accelerators for both established and innovative applications. PMID:27089200

  19. Synchrotron radiation external beam rotational radiotherapy of breast cancer: proof of principle.

    PubMed

    Di Lillo, Francesca; Mettivier, Giovanni; Castriconi, Roberta; Sarno, Antonio; Stevenson, Andrew W; Hall, Chris J; Häusermann, Daniel; Russo, Paolo

    2018-05-01

    The principle of rotational summation of the absorbed dose for breast cancer treatment with orthovoltage X-ray beams was proposed by J. Boone in 2012. Here, use of X-ray synchrotron radiation for image guided external beam rotational radiotherapy treatment of breast cancer is proposed. Tumor irradiation occurs with the patient in the prone position hosted on a rotating bed, with her breast hanging from a hole in the bed, which rotates around a vertical axis passing through the tumor site. Horizontal collimation of the X-ray beam provides for whole breast or partial breast irradiation, while vertical translation of the bed and successive rotations allow for irradiation of the full tumor volume, with dose rates which permit also hypofractionated treatments. In this work, which follows a previous preliminary report, results are shown of a full series of measurements on polyethylene and acrylic cylindrical phantoms carried out at the Australian Synchrotron, confirmed by Geant4 Monte Carlo simulations, intended to demonstrate the proof of principle of the technique. Dose measurements were carried out with calibrated ion chambers, radiochromic films and thermoluminescence dosimeters. The photon energy investigated was 60 keV. Image guidance may occur with the transmitted beam for contrast-enhanced breast computed tomography. For a horizontal beam collimation of 1.5 cm and rotation around the central axis of a 14 cm-diameter polyethylene phantom, a periphery-to-center dose ratio of 14% was measured. The simulations showed that under the same conditions the dose ratio decreases with increasing photon energy down to 10% at 175 keV. These values are comparable with those achievable with conventional megavoltage radiotherapy of breast cancer with a medical linear accelerator. Dose painting was demonstrated with two off-center `cancer foci' with 1.3 Gy and 0.6 Gy target doses. The use of a radiosensitizing agent for dose enhancement is foreseen.

  20. Determining paediatric patient thickness from a single digital radiograph-a proof of principle.

    PubMed

    Worrall, Mark; Vinnicombe, Sarah; Sutton, David G

    2018-04-05

    This work presents a proof of principle for a method of estimating the thickness of an attenuator from a single radiograph using the image, the exposure factors with which it was acquired and a priori knowledge of the characteristics of the X-ray unit and detector used for the exposure. It is intended this could be developed into a clinical tool to assist with paediatric patient dose audit, for which a measurement of patient size is required. The proof of principle used measured pixel value and effective linear attenuation coefficient to estimate the thickness of a Solid Water attenuator. The kerma at the detector was estimated using a measurement of pixel value on the image and measured detector calibrations. The initial kerma was estimated using a lookup table of measured output values. The effective linear attenuation coefficient was measured for Solid Water at varying kV p . 11 test images of known and varying thicknesses of Solid Water were acquired at 60, 70 and 81 kV p . Estimates of attenuator thickness were made using the model and the results compared to the known thickness. Estimates of attenuator thickness made using the model differed from the known thickness by 3.8 mm (3.2%) on average, with a range of 0.5-10.8 mm (0.5-9%). A proof of principle is presented for a method of estimating the thickness of an attenuator using a single radiograph of the attenuator. The method has been shown to be accurate using a Solid Water attenuator, with a maximum difference between estimated and known attenuator thickness of 10.8 mm (9%). The method shows promise as a clinical tool for estimating abdominal paediatric patient thickness for paediatric patient dose audit, and is only contingent on the type of data routinely collected by Medical Physics departments. Advances in knowledge: A computational model has been created that is capable of accurately estimating the thickness of a uniform attenuator using only the radiographic image, the exposure factors with which

  1. Cyclotron autoresonant accelerator for electron beam dry scrubbing of flue gases

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaPointe, M.A.; Hirshfield, J.L.; Hirshfield, J.L.

    1999-06-01

    Design and construction is underway for a novel rf electron accelerator for electron beam dry scrubbing (EBDS) of flue gases emanating from fossil-fuel burners. This machine, a cyclotron autoresonance accelerator (CARA), has already shown itself capable of converting rf power to electron beam power with efficiency values as high as 96{percent}. This proof-of-principle experiment will utilize a 300 kV, 33 A Pierce type electron gun and up to 24 MW of available rf power at 2.856 GHz to produce 1.0 MeV, 33 MW electron beam pulses. The self-scanning conical beam from the high power CARA will be evaluated for EBDSmore » and other possible environmental applications. {copyright} {ital 1999 American Institute of Physics.}« less

  2. The FAST (FRC Acceleration Space Thruster) Experiment

    NASA Technical Reports Server (NTRS)

    Martin, Adam; Eskridge, R.; Lee, M.; Richeson, J.; Smith, J.; Thio, Y. C. F.; Slough, J.; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    The Field Reverse Configuration (FRC) is a magnetized plasmoid that has been developed for use in magnetic confinement fusion. Several of its properties suggest that it may also be useful as a thruster for in-space propulsion. The FRC is a compact toroid that has only poloidal field, and is characterized by a high plasma beta = (P)/(B (sup 2) /2Mu0), the ratio of plasma pressure to magnetic field pressure, so that it makes efficient use of magnetic field to confine a plasma. In an FRC thruster, plasmoids would be repetitively formed and accelerated to high velocity; velocities of = 250 km/s (Isp = 25,000s) have already been achieved in fusion experiments. The FRC is inductively formed and accelerated, and so is not subject to the problem of electrode erosion. As the plasmoid may be accelerated over an extended length, it can in principle be made very efficient. And the achievable jet powers should be scalable to the MW range. A 10 kW thruster experiment - FAST (FRC Acceleration Space Thruster) has just started at the Marshall Space Flight Center. The design of FAST and the status of construction and operation will be presented.

  3. The principle of phase stability and the accelerator program at Berkeley, 1945--1954

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lofgren, E.J.

    1994-07-01

    The discovery of the Principle of Phase Stability by Vladimir Veksler and Edwin McMillian and the end of the war released a surge of accelerator activity at the Lawrence Berkeley Laboratory (then The University of California Radiation Laboratory). Six accelerators incorporating the Principle of Phase Stability were built in the period 1945--1954.

  4. Proof-of-principle experimental realization of a qubit-like qudit-based quantum key distribution scheme

    NASA Astrophysics Data System (ADS)

    Wang, Shuang; Yin, Zhen-Qiang; Chau, H. F.; Chen, Wei; Wang, Chao; Guo, Guang-Can; Han, Zheng-Fu

    2018-04-01

    In comparison to qubit-based protocols, qudit-based quantum key distribution ones generally allow two cooperative parties to share unconditionally secure keys under a higher channel noise. However, it is very hard to prepare and measure the required quantum states in qudit-based protocols in general. One exception is the recently proposed highly error tolerant qudit-based protocol known as the Chau15 (Chau 2015 Phys. Rev. A 92 062324). Remarkably, the state preparation and measurement in this protocol can be done relatively easily since the required states are phase encoded almost like the diagonal basis states of a qubit. Here we report the first proof-of-principle demonstration of the Chau15 protocol. One highlight of our experiment is that its post-processing is based on practical one-way manner, while the original proposal in Chau (2015 Phys. Rev. A 92 062324) relies on complicated two-way post-processing, which is a great challenge in experiment. In addition, by manipulating time-bin qudit and measurement with a variable delay interferometer, our realization is extensible to qudit with high-dimensionality and confirms the experimental feasibility of the Chau15 protocol.

  5. Experimental observation of direct particle acceleration by stimulated emission of radiation.

    PubMed

    Banna, Samer; Berezovsky, Valery; Schächter, Levi

    2006-09-29

    We report the first experimental evidence for direct particle acceleration by stimulated emission of radiation. In the framework of this proof-of-principle experiment, a 45 MeV electron macrobunch was modulated by a high-power CO2 laser and then injected into an excited CO2 gas mixture. The emerging microbunches experienced a 0.15% relative change in the kinetic energy, in a less than 40 cm long interaction region. According to our experimental results, a fraction of these electrons have gained more than 200 keV each, implying that such an electron has undergone an order of magnitude of 2 x 10(6) collisions of the second kind.

  6. Axial focusing of impact energy in the Earth's interior: Proof-of-principle tests of a new hypothesis

    NASA Technical Reports Server (NTRS)

    Boslough, M. B.; Chael, E. P.; Trucano, T. G.; Kipp, M. E.; Crawford, D. A.

    1994-01-01

    A causal link between major impact events and global processes would probably require a significant change in the thermal state of the Earth's interior, presumably brought about by coupling of impact energy. One possible mechanism for such energy coupling from the surface to the deep interior would be through focusing due to axial symmetry. Antipodal focusing of surface and body waves from earthquakes is a well-known phenomenon which has previously been exploited by seismologists in studies of the Earth's deep interior. Antipodal focusing from impacts on the Moon, Mercury, and icy satellites has also been invoked by planetary scientists to explain unusual surface features opposite some of the large impact structures on these bodies. For example, 'disrupted' terrains have been observed antipodal to the Caloris impact basis on Mercury and Imbrium Basin on the Moon. Very recently there have been speculations that antipodal focusing of impact energy within the mantle may lead to flood basalt and hotspot activity, but there has not yet been an attempt at a rigorous model. A new hypothesis was proposed and preliminary proof-of-principle tests for the coupling of energy from major impacts to the mantle by axial focusing of seismic waves was performed. Because of the axial symmetry of the explosive source, the phases and amplitudes are dependent only on ray parameter (or takeoff angle) and are independent of azimuthal angle. For a symmetric and homogeneous Earth, all the seismic energy radiated by the impact at a given takeoff angle will be refocused (minus attenuation) on the axis of symmetry, regardless of the number of reflections and refractions it has experienced. Mantle material near the axis of symmetry will experience more strain cycles with much greater amplitude than elsewhere and will therefore experience more irreversible heating. The situation is very different than for a giant earthquake, which in addition to having less energy, has an asymmetric focal

  7. Beyond injection: Trojan horse underdense photocathode plasma wakefield acceleration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hidding, B.; Rosenzweig, J. B.; Xi, Y.

    2012-12-21

    An overview on the underlying principles of the hybrid plasma wakefield acceleration scheme dubbed 'Trojan Horse' acceleration is given. The concept is based on laser-controlled release of electrons directly into a particle-beam-driven plasma blowout, paving the way for controlled, shapeable electron bunches with ultralow emittance and ultrahigh brightness. Combining the virtues of a low-ionization-threshold underdense photocathode with the GV/m-scale electric fields of a practically dephasing-free beam-driven plasma blowout, this constitutes a 4th generation electron acceleration scheme. It is applicable as a beam brightness transformer for electron bunches from LWFA and PWFA systems alike. At FACET, the proof-of-concept experiment 'E-210: Trojanmore » Horse Plasma Wakefield Acceleration' has recently been approved and is in preparation. At the same time, various LWFA facilities are currently considered to host experiments aiming at stabilizing and boosting the electron bunch output quality via a trojan horse afterburner stage. Since normalized emittance and brightness can be improved by many orders of magnitude, the scheme is an ideal candidate for light sources such as free-electron-lasers and those based on Thomson scattering and betatron radiation alike.« less

  8. Accelerating proof of concept for small molecule drugs using solid-state chemistry.

    PubMed

    Byrn, Stephen R; Zografi, George; Chen, Xiaoming Sean

    2010-09-01

    In this perspective we have shown that the process of "proof of concept" (POC) in the early part of drug development can be greatly accelerated by close attention to the underlying solid-state chemistry (SSC) of a new chemical entity. POC seeks data that provide confidence in the therapeutic activity and safety of a new chemical entity, which can rapidly lead to a key "GO/NO-GO" decision point for further development. Due to the high cost of the development of new chemical entities and the current low overall productivity of obtaining successful candidates, the pharmaceutical industry is being required to develop accelerated POC strategies. The success of accelerated approaches to POC depends on a full understanding of the SSC of drugs in relation to solubility and stability. Dissolution-limited absorption due to poor solubility of drug substances is particularly important because it can lead to low exposure in animals and undesired bioavailability in humans. Choosing a desirable solid form with sufficient solubility and acceptable stability is essential in developing formulations for POC with superior quality. In this perspective we present an approach that utilizes SSC as part of a novel 2-year development strategy for reaching the pivotal clinical trial stage of development.

  9. Controlling laser driven protons acceleration using a deformable mirror at a high repetition rate

    NASA Astrophysics Data System (ADS)

    Noaman-ul-Haq, M.; Sokollik, T.; Ahmed, H.; Braenzel, J.; Ehrentraut, L.; Mirzaie, M.; Yu, L.-L.; Sheng, Z. M.; Chen, L. M.; Schnürer, M.; Zhang, J.

    2018-03-01

    We present results from a proof-of-principle experiment to optimize laser driven protons acceleration by directly feeding back its spectral information to a deformable mirror (DM) controlled by evolutionary algorithms (EAs). By irradiating a stable high-repetition rate tape driven target with ultra-intense pulses of intensities ∼1020 W/ cm2, we optimize the maximum energy of the accelerated protons with a stability of less than ∼5% fluctuations near optimum value. Moreover, due to spatio-temporal development of the sheath field, modulations in the spectrum are also observed. Particularly, a prominent narrow peak is observed with a spread of ∼15% (FWHM) at low energy part of the spectrum. These results are helpful to develop high repetition rate optimization techniques required for laser-driven ion accelerators.

  10. A new type of accelerator for charged particle cancer therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edgecock, Rob

    2013-04-19

    Non-scaling Fixed Field Alternating Gradient accelerators (ns-FFAGs) show great potential for the acceleration of protons and light ions for the treatment of certain cancers. They have unique features as they combine techniques from the existing types of accelerators, cyclotrons and synchrotrons, and hence look to have advantages over both for this application. However, these unique features meant that it was necessary to build one of these accelerators to show that it works and to undertake a detailed conceptual design of a medical machine. Both of these have now been done. This paper will describe the concepts of this type ofmore » accelerator, show results from the proof-of-principle machine (EMMA) and described the medical machine (PAMELA).« less

  11. Proof of principle in vitro study of a prototype ultrasound technology to size stone fragments during ureteroscopy.

    PubMed

    Sorensen, Mathew D; Teichman, Joel M H; Bailey, Michael R

    2009-07-01

    Proof-of-principle in vitro experiments evaluated a prototype ultrasound technology to size kidney stone fragments. Nineteen human stones were measured using manual calipers. A 10-MHz, 1/8'' (10F) ultrasound transducer probe pinged each stone on a kidney tissue phantom submerged in water using two methods. In Method 1, the instrument was aligned such that the ultrasound pulse traveled through the stone. In Method 2, the instrument was aligned partially over the stone such that the ultrasound pulse traveled through water. For Method 1, the correlation between caliper- and ultrasound-determined stone size was r(2) = 0.71 (P < 0.0001). All but two stone measurements were accurate and precise to within 1 mm. For Method 2, the correlation was r(2) = 0.99 (P < 0.0001), and measurements were accurate and precise to within 0.25 mm. The prototype technology and either method measured stone size with good accuracy and precision. This technology may be possible to incorporate into ureteroscopy.

  12. A Novel Angular Acceleration Sensor Based on the Electromagnetic Induction Principle and Investigation of Its Calibration Tests

    PubMed Central

    Zhao, Hao; Feng, Hao

    2013-01-01

    An angular acceleration sensor can be used for the dynamic analysis of human and joint motions. In this paper, an angular acceleration sensor with novel structure based on the principle of electromagnetic induction is designed. The method involves the construction of a constant magnetic field by the excitation windings of sensor, and the cup-shaped rotor that cut the magnetic field. The output windings of the sensor generate an electromotive force, which is directly proportional to the angular acceleration through the electromagnetic coupling when the rotor has rotational angular acceleration. The mechanical structure and the magnetic working circuit of the sensor are described. The output properties and the mathematical model including the transfer function and state-space model of the sensor are established. The asymptotical stability of the sensor when it is working is verified by the Lyapunov Theorem. An angular acceleration calibration device based on the torsional pendulum principle is designed. The method involves the coaxial connection of the angular acceleration sensor, torsion pendulum and a high-precision angle sensor, and then an initial external force is applied to the torsion pendulum to produce a periodic damping angle oscillation. The angular acceleration sensor and the angle sensor will generate two corresponding electrical signals. The sensitivity coefficient of the angular acceleration sensor can be obtained after processing these two-channel signals. The experiment results show that the sensitivity coefficient of the sensor is about 17.29 mv/Krad·s2. Finally, the errors existing in the practical applications of the sensor are discussed and the corresponding improvement measures are proposed to provide effective technical support for the practical promotion of the novel sensor. PMID:23941911

  13. Design, Fabrication and Levitation Experiments of a Micromachined Electrostatically Suspended Six-Axis Accelerometer

    PubMed Central

    Cui, Feng; Liu, Wu; Chen, Wenyuan; Zhang, Weiping; Wu, Xiaosheng

    2011-01-01

    A micromachined electrostatically suspended six-axis accelerometer, with a square plate as proof mass housed by a top stator and bottom stator, is presented. The device structure and related techniques concerning its operating principles, such as calculation of capacitances and electrostatic forces/moments, detection and levitation control of the proof mass, acceleration measurement, and structural parameters design, are described. Hybrid MEMS manufacturing techniques, including surface micromachining fabrication of thin film electrodes and interconnections, integration fabrication of thick nickel structures about 500 μm using UV-LIGA by successful removal of SU-8 photoresist mold, DRIE of silicon proof mass in thickness of 450 μm, microassembly and solder bonding, were employed to fabricate this prototype microdevice. A levitation experiment system for the fabricated microaccelerometer chip is introduced, and levitation results show that fast initial levitation within 10 ms and stable full suspension of the proof mass have been successfully demonstrated. PMID:22247662

  14. [Understanding mistake-proofing].

    PubMed

    de Saint Maurice, G; Giraud, N; Ausset, S; Auroy, Y; Lenoir, B; Amalberti, R

    2011-01-01

    The mistake-proofing concept often refers to physical devices that prevent actors from making a wrong action. In anaesthesiology, one immediately thinks to specific design of outlets for medical gases. More generally, the principle of mistake-proofing is to avoid an error, by placing knowledge in the world rather than knowledge in the head. As it often happens in risk management, healthcare has received information transfers from the industry. Computer is changing the concept of mistake-proofing, initially based on physical design, such as aerospace and automotive industry. The mistake-proofing concept may be applied to prevention, detection, and mitigation of errors. The forcing functions are a specific part of mistake-proofing: they prevent a wrong action or they force a virtuous one. Grout proposes a little shortcut to identify mistake-proofing devices: "If it is not possible to picture it in action, it is probably not a mistake-proofing device". Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  15. Identification of lymphogranuloma venereum-associated Chlamydia trachomatis serovars by fluorescence in situ hybridisation--a proof-of-principle analysis.

    PubMed

    Frickmann, Hagen; Essig, Andreas; Poppert, Sven

    2014-04-01

    We describe a proof-of-principle evaluation of a fluorescence in situ hybridisation (FISH) procedure to identify Chlamydia trachomatis serovars L1-L3, the causative agents of lymphogranuloma venereum, in cell cultures based on newly designed DNA probes. Rapid and easy-to-perform FISH could facilitate the diagnosis of lymphogranuloma venereum without nucleic acid amplification or serotyping, but requires broader evaluation studies, for example, in tropical high-endemicity regions. © 2014 John Wiley & Sons Ltd.

  16. Querying Proofs (Work in Progress)

    NASA Technical Reports Server (NTRS)

    Aspinall, David; Denney, Ewen; Lueth, Christoph

    2011-01-01

    We motivate and introduce the basis for a query language designed for inspecting electronic representations of proofs. We argue that there is much to learn from large proofs beyond their validity, and that a dedicated query language can provide a principled way of implementing a family of useful operations.

  17. Calibration Device Designed for proof ring used in SCC Experiment

    NASA Astrophysics Data System (ADS)

    Hu, X. Y.; Kang, Z. Y.; Yu, Y. L.

    2017-11-01

    In this paper, a calibration device for proof ring used in SCC (Stress Corrosion Cracking) experiment was designed. A compact size loading device was developed to replace traditional force standard machine or a long screw nut. The deformation of the proof ring was measured by a CCD (Charge-Coupled Device) during the calibration instead of digital caliper or a dial gauge. The calibration device was verified at laboratory that the precision of force loading is ±0.1% and the precision of deformation measurement is ±0.002mm.

  18. Acceleration of neutrons in a scheme of a tautochronous mathematical pendulum (physical principles)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rivlin, Lev A

    We consider the physical principles of neutron acceleration through a multiple synchronous interaction with a gradient rf magnetic field in a scheme of a tautochronous mathematical pendulum. (laser applications and other aspects of quantum electronics)

  19. Design and Proof-of-Concept Use of a Circular PMMA Platform with 16-Well Sample Capacity for Microwave-Accelerated Bioassays.

    PubMed

    Mohammed, Muzaffer; Aslan, Kadir

    2013-01-01

    We demonstrate the design and the proof-of-concept use of a new, circular poly(methyl methacrylate)-based bioassay platform (PMMA platform), which affords for the rapid processing of 16 samples at once. The circular PMMA platform (5 cm in diameter) was coated with a silver nanoparticle film to accelerate the bioassay steps by microwave heating. A model colorimetric bioassay for biotinylated albumin (using streptavidin-labeled horse radish peroxidase) was performed on the PMMA platform coated with and without silver nanoparticles (a control experiment), and at room temperature and using microwave heating. It was shown that the simulated temperature profile of the PMMA platform during microwave heating were comparable to the real-time temperature profile during actual microwave heating of the constructed PMMA platform in a commercial microwave oven. The model colorimetric bioassay for biotinylated albumin was successfully completed in ~2 min (total assay time) using microwave heating, as compared to 90 min at room temperature (total assay time), which indicates a ~45-fold decrease in assay time. Our PMMA platform design afforded for significant reduction in non-specific interactions and low background signal as compared to non-silvered PMMA surfaces when employed in a microwave-accelerated bioassay carried out in a conventional microwave cavity.

  20. Design study of electron cyclotron resonance-ion plasma accelerator for heavy ion cancer therapy.

    PubMed

    Inoue, T; Hattori, T; Sugimoto, S; Sasai, K

    2014-02-01

    Electron Cyclotron Resonance-Ion Plasma Accelerator (ECR-IPAC) device, which theoretically can accelerate multiple charged ions to several hundred MeV with short acceleration length, has been proposed. The acceleration mechanism is based on the combination of two physical principles, plasma electron ion adiabatic ejection (PLEIADE) and Gyromagnetic Autoresonance (GYRAC). In this study, we have designed the proof of principle machine ECR-IPAC device and simulated the electromagnetic field distribution generating in the resonance cavity. ECR-IPAC device consisted of three parts, ECR ion source section, GYRAC section, and PLEIADE section. ECR ion source section and PLEIADE section were designed using several multi-turn solenoid coils and sextupole magnets, and GYRAC section was designed using 10 turns coil. The structure of ECR-IPAC device was the cylindrical shape, and the total length was 1024 mm and the maximum diameter was 580 mm. The magnetic field distribution, which maintains the stable acceleration of plasma, was generated on the acceleration center axis throughout three sections. In addition, the electric field for efficient acceleration of electrons was generated in the resonance cavity by supplying microwave of 2.45 GHz.

  1. Proof of principle experiments for helicon discharges in hydrogen

    NASA Astrophysics Data System (ADS)

    Briefi, Stefan; Fantz, Ursel

    2013-09-01

    In order to reduce the amount of power required for generating CW hydrogen discharges with high electron densities and a high degree of dissociation via RF coupling, the helicon concept is investigated. For this purpose a small laboratory experiment (length of the discharge vessel 40 cm, diameter 10 cm) has been built up. The RF generator has a maximum power of 600 W (frequency 13.56 MHz) and a Nagoya type III antenna is applied. As water cooling was avoided in constructing the experiment for simplicity, the induction coils can only generate a rather low magnetic field up to 14 mT. The performed investigations cover a variation of the RF power and the magnetic field in a pressure range between 0.3 and 10 Pa. Around a magnetic field of 3 mT the low field peak which is typical for helicon discharges could be observed. As the high density mode of helicon discharges has not yet been reached, a different RF generator (2 MHz, 2 KW) and water cooled induction coils will be applied in a next step in order to increase the available power and the magnetic field.

  2. Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Reinscheid, Uwe M.

    2009-08-01

    The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.

  3. Current driven instabilities of an electromagnetically accelerated plasma

    NASA Technical Reports Server (NTRS)

    Chouetri, E. Y.; Kelly, A. J.; Jahn, R. G.

    1988-01-01

    A plasma instability that strongly influences the efficiency and lifetime of electromagnetic plasma accelerators was quantitatively measured. Experimental measurements of dispersion relations (wave phase velocities), spatial growth rates, and stability boundaries are reported. The measured critical wave parameters are in excellent agreement with theoretical instability boundary predictions. The instability is current driven and affects a wide spectrum of longitudinal (electrostatic) oscillations. Current driven instabilities, which are intrinsic to the high-current-carrying magnetized plasma of the magnetoplasmadynmic (MPD) accelerator, were investigated with a kinetic theoretical model based on first principles. Analytical limits of the appropriate dispersion relation yield unstable ion acoustic waves for T(i)/T(e) much less than 1 and electron acoustic waves for T(i)/T(e) much greater than 1. The resulting set of nonlinear equations for the case of T(i)/T(e) = 1, of most interest to the MPD thruster Plasma Wave Experiment, was numerically solved to yield a multiparameter set of stability boundaries. Under certain conditions, marginally stable waves traveling almost perpendicular to the magnetic field would travel at a velocity equal to that of the electron current. Such waves were termed current waves. Unstable current waves near the upper stability boundary were observed experimentally and are in accordance with theoretical predictions. This provides unambiguous proof of the existence of such instabilites in electromagnetic plasma accelerators.

  4. Proof of Principle: Immobilisation of Robust CuII3 TbIII -Macrocycles on Small, Suitably Pre-functionalised Gold Nanoparticles.

    PubMed

    Feltham, Humphrey L C; Dumas, Christophe; Mannini, Matteo; Otero, Edwige; Sainctavit, Philippe; Sessoli, Roberta; Meledandri, Carla J; Brooker, Sally

    2017-02-21

    In a proof-of-principle study, a soluble macrocyclic single-molecule magnet (SMM) containing a Cu II 3 Tb III magnetic core was covalently grafted onto small gold nanoparticles pre-functionalised with carboxylate-terminated tethers. A modified microemulsion method allowed production of the small and monodisperse nanoparticles (approximately 3.5 nm in diameter) for the chemisorption of a large amount of intact macrocyclic complexes in the hybrid system. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Ergodicity, Maximum Entropy Production, and Steepest Entropy Ascent in the Proofs of Onsager's Reciprocal Relations

    NASA Astrophysics Data System (ADS)

    Benfenati, Francesco; Beretta, Gian Paolo

    2018-04-01

    We show that to prove the Onsager relations using the microscopic time reversibility one necessarily has to make an ergodic hypothesis, or a hypothesis closely linked to that. This is true in all the proofs of the Onsager relations in the literature: from the original proof by Onsager, to more advanced proofs in the context of linear response theory and the theory of Markov processes, to the proof in the context of the kinetic theory of gases. The only three proofs that do not require any kind of ergodic hypothesis are based on additional hypotheses on the macroscopic evolution: Ziegler's maximum entropy production principle (MEPP), the principle of time reversal invariance of the entropy production, or the steepest entropy ascent principle (SEAP).

  6. Proposal and proof-of-principle demonstration of non-destructive detection of photonic qubits using a Tm:LiNbO3 waveguide

    PubMed Central

    Sinclair, N.; Heshami, K.; Deshmukh, C.; Oblak, D.; Simon, C.; Tittel, W.

    2016-01-01

    Non-destructive detection of photonic qubits is an enabling technology for quantum information processing and quantum communication. For practical applications, such as quantum repeaters and networks, it is desirable to implement such detection in a way that allows some form of multiplexing as well as easy integration with other components such as solid-state quantum memories. Here, we propose an approach to non-destructive photonic qubit detection that promises to have all the mentioned features. Mediated by an impurity-doped crystal, a signal photon in an arbitrary time-bin qubit state modulates the phase of an intense probe pulse that is stored during the interaction. Using a thulium-doped waveguide in LiNbO3, we perform a proof-of-principle experiment with macroscopic signal pulses, demonstrating the expected cross-phase modulation as well as the ability to preserve the coherence between temporal modes. Our findings open the path to a new key component of quantum photonics based on rare-earth-ion-doped crystals. PMID:27853153

  7. Susceptibility of materials processing experiments to low-level accelerations

    NASA Technical Reports Server (NTRS)

    Naumann, R. J.

    1981-01-01

    The types of material processing experiments being considered for shuttle can be grouped into four categories: (1) contained solidification experiment; (2) quasicontainerless experiments; (3) containerless experiments; and (4) fluids experiments. Low level steady acceleration, compensated and uncompensated transient accelerations, and rotation induced flow factors that must be considered in the acceleration environment of a space vehicle whose importance depends on the type of experiment being performed. Some control of these factors may be exercised by the location and orientation of the experiment relative to shuttle and by the orbit vehicle attitude chosen for mission. The effects of the various residual accelerations can have serious consequence to the control of the experiment and must be factored into the design and operation of the apparatus.

  8. Proof-of-principle to unfold an angle-energy dependent source from forward and adjoint calculations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pace, J.V. III

    For many years there has existed a discrepancy between the measured and calculated responses from the Little Boy weapon in Hiroshima. A myriad of solutions have been proposed, but to no avail. If one can rationalize to himself that it does not really matter exactly what happened with the weapon when it exploded, and if sufficient information exist about the measurements, one should be able to unfold the source. Moreover, if a source can be unfolded in a controlled environment, then it should be possible to unfold a more complicated source, for example, the Little Boy source. This report recordsmore » the findings of a proof-of-principle test to unfold a source in the controlled environment.« less

  9. Space Acceleration Measurement System (SAMS)/Orbital Acceleration Research Experiment (OARE)

    NASA Technical Reports Server (NTRS)

    Hakimzadeh, Roshanak

    1998-01-01

    The Life and Microgravity Spacelab (LMS) payload flew on the Orbiter Columbia on mission STS-78 from June 20th to July 7th, 1996. The LMS payload on STS-78 was dedicated to life sciences and microgravity experiments. Two accelerometer systems managed by the NASA Lewis Research Center (LERC) flew to support these experiments, namely the Orbital Acceleration Research Experiment (OARE) and the Space Acceleration Measurements System (SAMS). In addition, the Microgravity Measurement Assembly (NOAA), managed by the European Space Research and Technology Center (ESA/ESTEC), and sponsored by NASA, collected acceleration data in support of the experiments on-board the LMS mission. OARE downlinked real-time quasi-steady acceleration data, which was provided to the investigators. The SAMS recorded higher frequency data on-board for post-mission analysis. The MMA downlinked real-time quasi-steady as well as higher frequency acceleration data, which was provided to the investigators. The Principal Investigator Microgravity Services (PIMS) project at NASA LERC supports principal investigators of microgravity experiments as they evaluate the effects of varying acceleration levels on their experiments. A summary report was prepared by PIMS to furnish interested experiment investigators with a guide to evaluate the acceleration environment during STS-78, and as a means of identifying areas which require further study. The summary report provides an overview of the STS-78 mission, describes the accelerometer systems flown on this mission, discusses some specific analyses of the accelerometer data in relation to the various activities which occurred during the mission, and presents plots resulting from these analyses as a snapshot of the environment during the mission. Numerous activities occurred during the STS-78 mission that are of interest to the low-gravity community. Specific activities of interest during this mission were crew exercise, radiator deployment, Vernier Reaction

  10. Accelerator/Experiment Operations - FY 2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Czarapata, P.; Geer, S.; Geesaman, D.

    2014-10-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2014. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2014 MINOS and MINERvA experiments using the Main Injector Neutrino Beam (NuMI), the MiniBooNE experiment running in the Booster Neutrino Beam (BNB), and the SeaQuest experiment and Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120). Each section was prepared by the relevant authors, and was somewhat edited for inclusion in this summary.

  11. Development of high intensity linear accelerator for heavy ion inertial fusion driver

    NASA Astrophysics Data System (ADS)

    Lu, Liang; Hattori, Toshiyuki; Hayashizaki, Noriyosu; Ishibashi, Takuya; Okamura, Masahiro; Kashiwagi, Hirotsugu; Takeuchi, Takeshi; Zhao, Hongwei; He, Yuan

    2013-11-01

    In order to verify the direct plasma injection scheme (DPIS), an acceleration test was carried out in 2001 using a radio frequency quadrupole (RFQ) heavy ion linear accelerator (linac) and a CO2-laser ion source (LIS) (Okamura et al., 2002) [1]. The accelerated carbon beam was observed successfully and the obtained current was 9.22 mA for C4+. To confirm the capability of the DPIS, we succeeded in accelerating 60 mA carbon ions with the DPIS in 2004 (Okamura et al., 2004; Kashiwagi and Hattori, 2004) [2,3]. We have studied a multi-beam type RFQ with an interdigital-H (IH) cavity that has a power-efficient structure in the low energy region. We designed and manufactured a two-beam type RFQ linac as a prototype for the multi-beam type linac; the beam acceleration test of carbon beams showed that it successfully accelerated from 5 keV/u up to 60 keV/u with an output current of 108 mA (2×54 mA/channel) (Ishibashi et al., 2011) [4]. We believe that the acceleration techniques of DPIS and the multi-beam type IH-RFQ linac are technical breakthroughs for heavy-ion inertial confinement fusion (HIF). The conceptual design of the RF linac with these techniques for HIF is studied. New accelerator-systems using these techniques for the HIF basic experiment are being designed to accelerate 400 mA carbon ions using four-beam type IH-RFQ linacs with DPIS. A model with a four-beam acceleration cavity was designed and manufactured to establish the proof of principle (PoP) of the accelerator.

  12. Querying Proofs

    NASA Technical Reports Server (NTRS)

    Aspinall, David; Denney, Ewen; Lueth, Christoph

    2012-01-01

    We motivate and introduce a query language PrQL designed for inspecting machine representations of proofs. PrQL natively supports hiproofs which express proof structure using hierarchical nested labelled trees. The core language presented in this paper is locally structured (first-order), with queries built using recursion and patterns over proof structure and rule names. We define the syntax and semantics of locally structured queries, demonstrate their power, and sketch some implementation experiments.

  13. Use of eculizumab in crescentic IgA nephropathy: proof of principle and conundrum?

    PubMed Central

    Ring, Troels; Pedersen, Birgitte Bang; Salkus, Giedrius; Goodship, Timothy H.J.

    2015-01-01

    IgA nephropathy (IgAN) is characterized by a variable clinical course and multifaceted pathophysiology. There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of the disease. Therefore, complement inhibition using the humanized anti-C5 monoclonal antibody eculizumab could be a rational treatment. We report here a 16-year-old male with the vasculitic form of IgAN who failed to respond to aggressive conventional therapy including high-dose steroids, cyclophosphamide and plasma exchange and who was treated with four weekly doses of 900 mg eculizumab followed by a single dose of 1200 mg. He responded rapidly to this treatment and has had a stable creatinine around 150 µmol/L (1.67 mg/dL) for >6 months. However, proteinuria was unabated on maximal conventional anti-proteinuric treatment, and a repeat renal biopsy 11 months after presentation revealed severe chronic changes. We believe this case provides proof of principle that complement inhibition may be beneficial in IgAN but also that development of chronicity may be independent of complement. PMID:26413271

  14. Accelerated Aging Experiments for Capacitor Health Monitoring and Prognostics

    NASA Technical Reports Server (NTRS)

    Kulkarni, Chetan S.; Celaya, Jose Ramon; Biswas, Gautam; Goebel, Kai

    2012-01-01

    This paper discusses experimental setups for health monitoring and prognostics of electrolytic capacitors under nominal operation and accelerated aging conditions. Electrolytic capacitors have higher failure rates than other components in electronic systems like power drives, power converters etc. Our current work focuses on developing first-principles-based degradation models for electrolytic capacitors under varying electrical and thermal stress conditions. Prognostics and health management for electronic systems aims to predict the onset of faults, study causes for system degradation, and accurately compute remaining useful life. Accelerated life test methods are often used in prognostics research as a way to model multiple causes and assess the effects of the degradation process through time. It also allows for the identification and study of different failure mechanisms and their relationships under different operating conditions. Experiments are designed for aging of the capacitors such that the degradation pattern induced by the aging can be monitored and analyzed. Experimental setups and data collection methods are presented to demonstrate this approach.

  15. Principles of Radio: A Laboratory Experiment

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2002-01-01

    An experiment is proposed for learning the principles of radio. A simple radio receiver illustrates amplitude modulation and demodulation, the selectivity of a receiver and the features of a directional antenna. Both normal and computerized versions of the experiment are described. The computerized experiment employs the "ScienceWorkshop"…

  16. Testing the Equivalence Principle in an Einstein Elevator: Detector Dynamics and Gravity Perturbations

    NASA Technical Reports Server (NTRS)

    Hubbard, Dorthy (Technical Monitor); Lorenzini, E. C.; Shapiro, I. I.; Cosmo, M. L.; Ashenberg, J.; Parzianello, G.; Iafolla, V.; Nozzoli, S.

    2003-01-01

    We discuss specific, recent advances in the analysis of an experiment to test the Equivalence Principle (EP) in free fall. A differential accelerometer detector with two proof masses of different materials free falls inside an evacuated capsule previously released from a stratospheric balloon. The detector spins slowly about its horizontal axis during the fall. An EP violation signal (if present) will manifest itself at the rotational frequency of the detector. The detector operates in a quiet environment as it slowly moves with respect to the co-moving capsule. There are, however, gravitational and dynamical noise contributions that need to be evaluated in order to define key requirements for this experiment. Specifically, higher-order mass moments of the capsule contribute errors to the differential acceleration output with components at the spin frequency which need to be minimized. The dynamics of the free falling detector (in its present design) has been simulated in order to estimate the tolerable errors at release which, in turn, define the release mechanism requirements. Moreover, the study of the higher-order mass moments for a worst-case position of the detector package relative to the cryostat has led to the definition of requirements on the shape and size of the proof masses.

  17. Multi-species first-principles simulations of particle acceleration at shocks

    NASA Astrophysics Data System (ADS)

    Caprioli, Damiano

    Astrophysical shocks are known to be prominent sources of non-thermal particles and emission. In particular, strong shocks at supernova remnant blast waves are thought to accelerate Galactic cosmic rays (CRs) up to about 10^17eV via diffusive shock acceleration (DSA). The chemical composition of Galactic CRs, now measured with great accuracy by payloads and satellites, is reminiscent of that of the typical interstellar medium, although with some significant deviations. Observations reveal: 1) an electron/proton ratio of about 1% at about 10 GeV, (2) a general enhancement of the refractory elements relative to the volatile ones, (3) among the volatile elements, an enhancement of the heavier elements relative to the lighter ones, and (4) a discrepant hardening of CR nuclei heavier than hydrogen. Such peculiar trends contain precious information about the dependence of the acceleration process on the particle mass/charge ratio, a trend that has no theoretical counterpart in the DSA theory, yet. Building on our recent successes in modeling electron and proton DSA at non-relativistic astrophysical shocks via first-principles kinetic simulations, we will perform multispecies particle-in-cells simulations of such systems also including nuclei heavier than hydrogen, in order to investigate thermalization, injection, and acceleration of species with different mass/charge ratio. We will also analyze how the simulation outputs compare with the observed CR abundances, in order to build a model for DSA that accounts for the relative acceleration efficiency of energetic electrons, protons, and heavier ions. Finally, we will assess the possible contribution of accelerated heavy ions, especially helium, to the generation of magnetic turbulence via CR-driven instabilities - crucial to foster rapid particle energgization- and to the hadronic gamma-ray emission from young supernova remnants.

  18. Enhancing the Therapy Experience Using Principles of Video Game Design.

    PubMed

    Folkins, John Wm; Brackenbury, Tim; Krause, Miriam; Haviland, Allison

    2016-02-01

    This article considers the potential benefits that applying design principles from contemporary video games may have on enhancing therapy experiences. Six principles of video game design are presented, and their relevance for enriching clinical experiences is discussed. The motivational and learning benefits of each design principle have been discussed in the education literature as having positive impacts on student motivation and learning and are related here to aspects of clinical practice. The essential experience principle suggests connecting all aspects of the experience around a central emotion or cognitive connection. The discovery principle promotes indirect learning in focused environments. The risk-taking principle addresses the uncertainties clients face when attempting newly learned skills in novel situations. The generalization principle encourages multiple opportunities for skill transfer. The reward system principle directly relates to the scaffolding of frequent and varied feedback in treatment. Last, the identity principle can assist clients in using their newly learned communication skills to redefine self-perceptions. These principles highlight areas for research and interventions that may be used to reinforce or advance current practice.

  19. Preservice Teacher Beliefs about Proofs.

    ERIC Educational Resources Information Center

    Mingus, Tabitha T. Y.; Grassl, Richard M.

    1999-01-01

    Describes the study of backgrounds, beliefs, and attitudes of teachers (n=51) about proofs. Explores four issues: (1) preservice teachers' experiences/exposure to proof; (2) their beliefs about what constitutes proof; (3) the role of proof in mathematics; and (4) their beliefs about when proof should be introduced in K-12 math classes. Discusses…

  20. Accelerator Production of Isotopes for Medical Use

    NASA Astrophysics Data System (ADS)

    Lapi, Suzanne

    2014-03-01

    The increase in use of radioisotopes for medical imaging and therapy has led to the development of novel routes of isotope production. For example, the production and purification of longer-lived position emitting radiometals has been explored to allow for nuclear imaging agents based on peptides, antibodies and nanoparticles. These isotopes (64Cu, 89Zr, 86Y) are typically produced via irradiation of solid targets on smaller medical cyclotrons at dedicated facilities. Recently, isotope harvesting from heavy ion accelerator facilities has also been suggested. The Facility for Rare Isotope Beams (FRIB) will be a new national user facility for nuclear science to be completed in 2020. Radioisotopes could be produced by dedicated runs by primary users or may be collected synergistically from the water in cooling-loops for the primary beam dump that cycle the water at flow rates in excess of hundreds of gallons per minute. A liquid water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory (NSCL) was designed and constructed as the initial step in proof-of-principle experiments to harvest useful radioisotopes in this manner. This talk will provide an overview of isotope production using both dedicated machines and harvesting from larger accelerators typically used for nuclear physics. Funding from Department of Energy under DESC0007352 and DESC0006862.

  1. Infrared laser induced population transfer and parity selection in 14NH3: A proof of principle experiment towards detecting parity violation in chiral molecules

    NASA Astrophysics Data System (ADS)

    Dietiker, P.; Miloglyadov, E.; Quack, M.; Schneider, A.; Seyfang, G.

    2015-12-01

    We have set up an experiment for the efficient population transfer by a sequential two photon—absorption and stimulated emission—process in a molecular beam to prepare quantum states of well defined parity and their subsequent sensitive detection. This provides a proof of principle for an experiment which would allow for parity selection and measurement of the time evolution of parity in chiral molecules, resulting in a measurement of the parity violating energy difference ΔpvE between enantiomers of chiral molecules. Here, we present first results on a simple achiral molecule demonstrating efficient population transfer (about 80% on the average for each step) and unperturbed persistence of a selected excited parity level over flight times of about 1.3 ms in the beam. In agreement with model calculations with and without including nuclear hyperfine structure, efficient population transfer can be achieved by a rather simple implementation of the rapid adiabatic passage method of Reuss and coworkers and considering also the stimulated Raman adiabatic passage technique of Bergmann and coworkers as an alternative. The preparation step uses two powerful single mode continuous wave optical parametric oscillators of high frequency stability and accuracy. The detection uses a sensitive resonantly enhanced multiphoton ionization method after free flight lengths of up to 0.8 m in the molecular beam. Using this technique, we were able to also resolve the nuclear hyperfine structure in the rovibrational levels of the ν1 and ν3 fundamentals as well as the 2ν4 overtone of 14NH3, for which no previous data with hyperfine resolution were available. We present our new results on the quadrupole coupling constants for the ν1, ν3, and 2ν4 levels in the context of previously known data for ν2 and its overtone, as well as ν4, and the ground state. Thus, now, 14N quadrupole coupling constants for all fundamentals and some overtones of 14NH3 are known and can be used for

  2. Infrared laser induced population transfer and parity selection in (14)NH3: A proof of principle experiment towards detecting parity violation in chiral molecules.

    PubMed

    Dietiker, P; Miloglyadov, E; Quack, M; Schneider, A; Seyfang, G

    2015-12-28

    We have set up an experiment for the efficient population transfer by a sequential two photon-absorption and stimulated emission-process in a molecular beam to prepare quantum states of well defined parity and their subsequent sensitive detection. This provides a proof of principle for an experiment which would allow for parity selection and measurement of the time evolution of parity in chiral molecules, resulting in a measurement of the parity violating energy difference ΔpvE between enantiomers of chiral molecules. Here, we present first results on a simple achiral molecule demonstrating efficient population transfer (about 80% on the average for each step) and unperturbed persistence of a selected excited parity level over flight times of about 1.3 ms in the beam. In agreement with model calculations with and without including nuclear hyperfine structure, efficient population transfer can be achieved by a rather simple implementation of the rapid adiabatic passage method of Reuss and coworkers and considering also the stimulated Raman adiabatic passage technique of Bergmann and coworkers as an alternative. The preparation step uses two powerful single mode continuous wave optical parametric oscillators of high frequency stability and accuracy. The detection uses a sensitive resonantly enhanced multiphoton ionization method after free flight lengths of up to 0.8 m in the molecular beam. Using this technique, we were able to also resolve the nuclear hyperfine structure in the rovibrational levels of the ν1 and ν3 fundamentals as well as the 2ν4 overtone of (14)NH3, for which no previous data with hyperfine resolution were available. We present our new results on the quadrupole coupling constants for the ν1, ν3, and 2ν4 levels in the context of previously known data for ν2 and its overtone, as well as ν4, and the ground state. Thus, now, (14)N quadrupole coupling constants for all fundamentals and some overtones of (14)NH3 are known and can be used for

  3. Single-molecule enzymology based on the principle of the Millikan oil drop experiment.

    PubMed

    Leiske, Danielle L; Chow, Andrea; Dettloff, Roger; Farinas, Javier

    2014-03-01

    The ability to monitor the progress of single-molecule enzyme reactions is often limited by the need to use fluorogenic substrates. A method based on the principle of the Millikan oil drop experiment was developed to monitor the change in charge of substrates bound to a nanoparticle and offers a means of detecting single-enzyme reactions without fluorescence detection. As a proof of principle of the ability to monitor reactions that result in a change in substrate charge, polymerization on a single DNA template was detected. A custom oligonucleotide was synthesized that allowed for the attachment of single DNA templates to gold nanoparticles with a single polymer tether. The nanoparticles were then tethered to the surface of a microfluidic channel where the positions of the nanoparticles, subjected to an oscillating electric field, were monitored using dark field microscopy. With short averaging times, the signal-to-noise level was low enough to discriminate changes in charge of less than 1.2%. Polymerization of a long DNA template demonstrated the ability to use the system to monitor single-molecule enzymatic activity. Finally, nanoparticle surfaces were modified with thiolated moieties to reduce and/or shield the number of unproductive charges and allow for improved sensitivity. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Single-Molecule Enzymology Based On The Principle Of The Millikan Oil Drop Experiment

    PubMed Central

    Leiske, Danielle L.; Chow, Andrea; Dettloff, Roger; Farinas, Javier

    2014-01-01

    The ability to monitor the progress of single molecule enzyme reactions is often limited by the need to use fluorogenic substrates. A method based on the principle of the Millikan Oil Drop Experiment was developed to monitor the change in charge of substrates bound to a nanoparticle and offers a means of detecting single enzyme reactions without fluorescence detection. As a proof of principle of the ability to monitor reactions which result in a change in substrate charge, polymerization on a single DNA template was detected. A custom oligonucleotide was synthesized which allowed for the attachment of single DNA templates to gold nanoparticles with a single polymer tether. The nanoparticles were then tethered to the surface of a microfluidic channel where the positions of the nanoparticles, subjected to an oscillating electric field, were monitored using darkfield microscopy. With short averaging times, the signal-to-noise level was low enough to discriminate changes in charge of less than 1.2%. Polymerization of a long DNA template demonstrated the ability to use the system to monitor single molecule enzymatic activity. Finally, nanoparticle surfaces were modified with thiolated moieties in order to reduce and/or shield the number of unproductive charges and allow for improved sensitivity. PMID:24291542

  5. Proof of principle study of the use of a CMOS active pixel sensor for proton radiography.

    PubMed

    Seco, Joao; Depauw, Nicolas

    2011-02-01

    Proof of principle study of the use of a CMOS active pixel sensor (APS) in producing proton radiographic images using the proton beam at the Massachusetts General Hospital (MGH). A CMOS APS, previously tested for use in s-ray radiation therapy applications, was used for proton beam radiographic imaging at the MGH. Two different setups were used as a proof of principle that CMOS can be used as proton imaging device: (i) a pen with two metal screws to assess spatial resolution of the CMOS and (ii) a phantom with lung tissue, bone tissue, and water to assess tissue contrast of the CMOS. The sensor was then traversed by a double scattered monoenergetic proton beam at 117 MeV, and the energy deposition inside the detector was recorded to assess its energy response. Conventional x-ray images with similar setup at voltages of 70 kVp and proton images using commercial Gafchromic EBT 2 and Kodak X-Omat V films were also taken for comparison purposes. Images were successfully acquired and compared to x-ray kVp and proton EBT2/X-Omat film images. The spatial resolution of the CMOS detector image is subjectively comparable to the EBT2 and Kodak X-Omat V film images obtained at the same object-detector distance. X-rays have apparent higher spatial resolution than the CMOS. However, further studies with different commercial films using proton beam irradiation demonstrate that the distance of the detector to the object is important to the amount of proton scatter contributing to the proton image. Proton images obtained with films at different distances from the source indicate that proton scatter significantly affects the CMOS image quality. Proton radiographic images were successfully acquired at MGH using a CMOS active pixel sensor detector. The CMOS demonstrated spatial resolution subjectively comparable to films at the same object-detector distance. Further work will be done in order to establish the spatial and energy resolution of the CMOS detector for protons. The

  6. Proof of principle study of the use of a CMOS active pixel sensor for proton radiography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Seco, Joao; Depauw, Nicolas

    2011-02-15

    Purpose: Proof of principle study of the use of a CMOS active pixel sensor (APS) in producing proton radiographic images using the proton beam at the Massachusetts General Hospital (MGH). Methods: A CMOS APS, previously tested for use in s-ray radiation therapy applications, was used for proton beam radiographic imaging at the MGH. Two different setups were used as a proof of principle that CMOS can be used as proton imaging device: (i) a pen with two metal screws to assess spatial resolution of the CMOS and (ii) a phantom with lung tissue, bone tissue, and water to assess tissuemore » contrast of the CMOS. The sensor was then traversed by a double scattered monoenergetic proton beam at 117 MeV, and the energy deposition inside the detector was recorded to assess its energy response. Conventional x-ray images with similar setup at voltages of 70 kVp and proton images using commercial Gafchromic EBT 2 and Kodak X-Omat V films were also taken for comparison purposes. Results: Images were successfully acquired and compared to x-ray kVp and proton EBT2/X-Omat film images. The spatial resolution of the CMOS detector image is subjectively comparable to the EBT2 and Kodak X-Omat V film images obtained at the same object-detector distance. X-rays have apparent higher spatial resolution than the CMOS. However, further studies with different commercial films using proton beam irradiation demonstrate that the distance of the detector to the object is important to the amount of proton scatter contributing to the proton image. Proton images obtained with films at different distances from the source indicate that proton scatter significantly affects the CMOS image quality. Conclusion: Proton radiographic images were successfully acquired at MGH using a CMOS active pixel sensor detector. The CMOS demonstrated spatial resolution subjectively comparable to films at the same object-detector distance. Further work will be done in order to establish the spatial and energy resolution

  7. Children's Acquisition of Arithmetic Principles: The Role of Experience

    ERIC Educational Resources Information Center

    Prather, Richard; Alibali, Martha W.

    2011-01-01

    The current study investigated how young learners' experiences with arithmetic equations can lead to learning of an arithmetic principle. The focus was elementary school children's acquisition of the Relation to Operands principle for subtraction (i.e., for natural numbers, the difference must be less than the minuend). In Experiment 1, children…

  8. A survey of noninteractive zero knowledge proof system and its applications.

    PubMed

    Wu, Huixin; Wang, Feng

    2014-01-01

    Zero knowledge proof system which has received extensive attention since it was proposed is an important branch of cryptography and computational complexity theory. Thereinto, noninteractive zero knowledge proof system contains only one message sent by the prover to the verifier. It is widely used in the construction of various types of cryptographic protocols and cryptographic algorithms because of its good privacy, authentication, and lower interactive complexity. This paper reviews and analyzes the basic principles of noninteractive zero knowledge proof system, and summarizes the research progress achieved by noninteractive zero knowledge proof system on the following aspects: the definition and related models of noninteractive zero knowledge proof system, noninteractive zero knowledge proof system of NP problems, noninteractive statistical and perfect zero knowledge, the connection between noninteractive zero knowledge proof system, interactive zero knowledge proof system, and zap, and the specific applications of noninteractive zero knowledge proof system. This paper also points out the future research directions.

  9. A Survey of Noninteractive Zero Knowledge Proof System and Its Applications

    PubMed Central

    Wu, Huixin; Wang, Feng

    2014-01-01

    Zero knowledge proof system which has received extensive attention since it was proposed is an important branch of cryptography and computational complexity theory. Thereinto, noninteractive zero knowledge proof system contains only one message sent by the prover to the verifier. It is widely used in the construction of various types of cryptographic protocols and cryptographic algorithms because of its good privacy, authentication, and lower interactive complexity. This paper reviews and analyzes the basic principles of noninteractive zero knowledge proof system, and summarizes the research progress achieved by noninteractive zero knowledge proof system on the following aspects: the definition and related models of noninteractive zero knowledge proof system, noninteractive zero knowledge proof system of NP problems, noninteractive statistical and perfect zero knowledge, the connection between noninteractive zero knowledge proof system, interactive zero knowledge proof system, and zap, and the specific applications of noninteractive zero knowledge proof system. This paper also points out the future research directions. PMID:24883407

  10. Estimates of effects of residual acceleration on USML-1 experiments

    NASA Technical Reports Server (NTRS)

    Naumann, Robert J.

    1995-01-01

    The purpose of this study effort was to develop analytical models to describe the effects of residual accelerations on the experiments to be carried on the first U.S. Microgravity Lab mission (USML-1) and to test the accuracy of these models by comparing the pre-flight predicted effects with the post-flight measured effects. After surveying the experiments to be performed on USML-1, it became evident that the anticipated residual accelerations during the USML-1 mission were well below the threshold for most of the primary experiments and all of the secondary (Glovebox) experiments and that the only set of experiments that could provide quantifiable effects, and thus provide a definitive test of the analytical models, were the three melt growth experiments using the Bridgman-Stockbarger type Crystal Growth Furnace (CGF). This class of experiments is by far the most sensitive to low level quasi-steady accelerations that are unavoidable on space craft operating in low earth orbit. Because of this, they have been the drivers for the acceleration requirements imposed on the Space Station. Therefore, it is appropriate that the models on which these requirements are based are tested experimentally. Also, since solidification proceeds directionally over a long period of time, the solidified ingot provides a more or less continuous record of the effects from acceleration disturbances.

  11. Reducing intrusive traumatic memories after emergency caesarean section: A proof-of-principle randomized controlled study.

    PubMed

    Horsch, Antje; Vial, Yvan; Favrod, Céline; Harari, Mathilde Morisod; Blackwell, Simon E; Watson, Peter; Iyadurai, Lalitha; Bonsall, Michael B; Holmes, Emily A

    2017-07-01

    Preventative psychological interventions to aid women after traumatic childbirth are needed. This proof-of-principle randomized controlled study evaluated whether the number of intrusive traumatic memories mothers experience after emergency caesarean section (ECS) could be reduced by a brief cognitive intervention. 56 women after ECS were randomized to one of two parallel groups in a 1:1 ratio: intervention (usual care plus cognitive task procedure) or control (usual care). The intervention group engaged in a visuospatial task (computer-game 'Tetris' via a handheld gaming device) for 15 min within six hours following their ECS. The primary outcome was the number of intrusive traumatic memories related to the ECS recorded in a diary for the week post-ECS. As predicted, compared with controls, the intervention group reported fewer intrusive traumatic memories (M = 4.77, SD = 10.71 vs. M = 9.22, SD = 10.69, d = 0.647 [95% CI: 0.106, 1.182]) over 1 week (intention-to-treat analyses, primary outcome). There was a trend towards reduced acute stress re-experiencing symptoms (d = 0.503 [95% CI: -0.032, 1.033]) after 1 week (intention-to-treat analyses). Times series analysis on daily intrusions data confirmed the predicted difference between groups. 72% of women rated the intervention "rather" to "extremely" acceptable. This represents a first step in the development of an early (and potentially universal) intervention to prevent postnatal posttraumatic stress symptoms that may benefit both mother and child. ClinicalTrials.gov, www.clinicaltrials.gov, NCT02502513. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Burden of Proof in Bioethics.

    PubMed

    Koplin, Julian J; Selgelid, Michael J

    2015-11-01

    A common strategy in bioethics is to posit a prima facie case in favour of one policy, and to then claim that the burden of proof (that this policy should be rejected) falls on those with opposing views. If the burden of proof is not met, it is claimed, then the policy in question should be accepted. This article illustrates, and critically evaluates, examples of this strategy in debates about the sale of organs by living donors, human enhancement, and the precautionary principle. We highlight general problems with this style of argument, and particular problems with its use in specific cases. We conclude that the burden ultimately falls on decision-makers (i.e. policy-makers) to choose the policy supported by the best reasons. © 2015 John Wiley & Sons Ltd.

  13. Accelerating the commercialization of university technologies for military healthcare applications: the role of the proof of concept process

    NASA Astrophysics Data System (ADS)

    Ochoa, Rosibel; DeLong, Hal; Kenyon, Jessica; Wilson, Eli

    2011-06-01

    The von Liebig Center for Entrepreneurism and Technology Advancement at UC San Diego (vonliebig.ucsd.edu) is focused on accelerating technology transfer and commercialization through programs and education on entrepreneurism. Technology Acceleration Projects (TAPs) that offer pre-venture grants and extensive mentoring on technology commercialization are a key component of its model which has been developed over the past ten years with the support of a grant from the von Liebig Foundation. In 2010, the von Liebig Entrepreneurism Center partnered with the U.S. Army Telemedicine and Advanced Technology Research Center (TATRC), to develop a regional model of Technology Acceleration Program initially focused on military research to be deployed across the nation to increase awareness of military medical needs and to accelerate the commercialization of novel technologies to treat the patient. Participants to these challenges are multi-disciplinary teams of graduate students and faculty in engineering, medicine and business representing universities and research institutes in a region, selected via a competitive process, who receive commercialization assistance and funding grants to support translation of their research discoveries into products or services. To validate this model, a pilot program focused on commercialization of wireless healthcare technologies targeting campuses in Southern California has been conducted with the additional support of Qualcomm, Inc. Three projects representing three different universities in Southern California were selected out of forty five applications from ten different universities and research institutes. Over the next twelve months, these teams will conduct proof of concept studies, technology development and preliminary market research to determine the commercial feasibility of their technologies. This first regional program will help build the needed tools and processes to adapt and replicate this model across other regions in the

  14. Accelerator-based neutrino oscillation experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harris, Deborah A.; /Fermilab

    2007-12-01

    Neutrino oscillations were first discovered by experiments looking at neutrinos coming from extra-terrestrial sources, namely the sun and the atmosphere, but we will be depending on earth-based sources to take many of the next steps in this field. This article describes what has been learned so far from accelerator-based neutrino oscillation experiments, and then describe very generally what the next accelerator-based steps are. In section 2 the article discusses how one uses an accelerator to make a neutrino beam, in particular, one made from decays in flight of charged pions. There are several different neutrino detection methods currently in use,more » or under development. In section 3 these are presented, with a description of the general concept, an example of such a detector, and then a brief discussion of the outstanding issues associated with this detection technique. Finally, section 4 describes how the measurements of oscillation probabilities are made. This includes a description of the near detector technique and how it can be used to make the most precise measurements of neutrino oscillations.« less

  15. Accelerated Application Development: The ORNL Titan Experience

    DOE PAGES

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; ...

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  16. Accelerated application development: The ORNL Titan experience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joubert, Wayne; Archibald, Rick; Berrill, Mark

    2015-08-01

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  17. Design and implementation of an array of micro-electrochemical detectors for two-dimensional liquid chromatography--proof of principle.

    PubMed

    Abia, Jude A; Putnam, Joel; Mriziq, Khaled; Guiochon, Georges A

    2010-03-05

    Simultaneous two-dimensional liquid chromatography (2D-LC) is an implementation of two-dimensional liquid chromatography which has the potential to provide very fast, yet highly efficient separations. It is based on the use of time x space and space x space separation systems. The basic principle of this instrument has been validated long ago by the success of two-dimensional thin layer chromatography. The construction of a pressurized wide and flat column (100 mm x 100 mm x 1 mm) operated under an inlet pressure of up to 50 bar was described previously. However, to become a modern analytical method, simultaneous 2D-LC requires the development of detectors suitable for the monitoring of the composition of the eluent of this pressurized planar, wide column. An array of five equidistant micro-electrochemical sensors was built for this purpose and tested. Each sensor is a three-electrode system, with the working electrode being a 25 microm polished platinum micro-electrode. The auxiliary electrode is a thin platinum wire and the reference electrode an Ag/AgCl (3M sat. KCl) electrode. In this first implementation, proof of principle is demonstrated, but the final instrument will require a much larger array. 2010 Elsevier B.V. All rights reserved.

  18. Resonant interaction of the electron beam with a synchronous wave in controlled magnetrons for high-current superconducting accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kazakevich, G.; Johnson, R.; Lebedev, V.

    A simplified analytical model of the resonant interaction of the beam of Larmor electrons drifting in the crossed constant fields of a magnetron with a synchronous wave providing a phase grouping of the drifting charge was developed to optimize the parameters of an rf resonant injected signal driving the magnetrons for management of phase and power of rf sources with a rate required for superconducting high-current accelerators. The model, which considers the impact of the rf resonant signal injected into the magnetron on the operation of the injection-locked tube, substantiates the recently developed method of fast power control of magnetronsmore » in the range up to 10 dB at the highest generation efficiency, with low noise, precise stability of the carrier frequency, and the possibility of wideband phase control. Experiments with continuous wave 2.45 GHz, 1 kW microwave oven magnetrons have verified the correspondence of the behavior of these tubes to the analytical model. A proof of the principle of the novel method of power control in magnetrons, based on the developed model, was demonstrated in the experiments. The method is attractive for high-current superconducting rf accelerators. This study also discusses vector methods of power control with the rates required for superconducting accelerators, the impact of the rf resonant signal injected into the magnetron on the rate of phase control of the injection-locked tubes, and a conceptual scheme of the magnetron transmitter with highest efficiency for high-current accelerators.« less

  19. Resonant interaction of the electron beam with a synchronous wave in controlled magnetrons for high-current superconducting accelerators

    DOE PAGES

    Kazakevich, G.; Johnson, R.; Lebedev, V.; ...

    2018-06-14

    A simplified analytical model of the resonant interaction of the beam of Larmor electrons drifting in the crossed constant fields of a magnetron with a synchronous wave providing a phase grouping of the drifting charge was developed to optimize the parameters of an rf resonant injected signal driving the magnetrons for management of phase and power of rf sources with a rate required for superconducting high-current accelerators. The model, which considers the impact of the rf resonant signal injected into the magnetron on the operation of the injection-locked tube, substantiates the recently developed method of fast power control of magnetronsmore » in the range up to 10 dB at the highest generation efficiency, with low noise, precise stability of the carrier frequency, and the possibility of wideband phase control. Experiments with continuous wave 2.45 GHz, 1 kW microwave oven magnetrons have verified the correspondence of the behavior of these tubes to the analytical model. A proof of the principle of the novel method of power control in magnetrons, based on the developed model, was demonstrated in the experiments. The method is attractive for high-current superconducting rf accelerators. This study also discusses vector methods of power control with the rates required for superconducting accelerators, the impact of the rf resonant signal injected into the magnetron on the rate of phase control of the injection-locked tubes, and a conceptual scheme of the magnetron transmitter with highest efficiency for high-current accelerators.« less

  20. Teaching experiences of second degree accelerated baccalaureate nursing faculty.

    PubMed

    Cangelosi, Pamela R

    2013-11-19

    Despite the extraordinary growth of accelerated second degree baccalaureate nursing programs, little research has been conducted about the experiences of faculty teaching these students. Using a hermeneutic phenomenological approach, this study explored the experiences of 14 accelerated second degree baccalaureate faculty from the eastern region of the United States. The data revealed that many faculty teaching second degree students feel unprepared and want guidance on how to teach these students, which was identified in the theme, Figuring It Out On My Own. This article describes this study and the implications of this theme for faculty recruitment and retention in accelerated second degree baccalaureate nursing programs.

  1. Proof Constructions and Evaluations

    ERIC Educational Resources Information Center

    Stylianides, Andreas J.; Stylianides, Gabriel J.

    2009-01-01

    In this article, we focus on a group of 39 prospective elementary (grades K-6) teachers who had rich experiences with proof, and we examine their ability to construct proofs and evaluate their own constructions. We claim that the combined "construction-evaluation" activity helps illuminate certain aspects of prospective teachers' and presumably…

  2. Accelerated Evolution in the Death Galaxy

    NASA Astrophysics Data System (ADS)

    Austin, Robert; Tung, Chih-Kuan; Gong, Xiu-Quing; Lambert, Guillaume; Liao, David

    2010-03-01

    We recall 4 main guiding principles of evolution: 1) instability of defections, 2) stress induced non-random mutations, 3) genetic heterogeneity, and 4) fragmented populations. Our previous preliminary experiments have been relatively simple 1-D stress experiments. We are proceeding with 2-D experiments whose design is guided by these principles. Our new experiment we have dubbed the Death Galaxy because of it's use of these design principles. The ``galaxy'' name comes from the fact that the structure is designed as an interconnected array of micro-ecologies, these micro-ecologies are similar to the stars that comprise an astronomical galaxy, and provide the fragmented small populations. A gradient of the antibiotic Cipro is introduced across the galaxy, and we will present results which show how bacterial evolution resulting in resistance to Cipro is accelerated by the physics principles underlying the device.

  3. Self-Explanation Training Improves Proof Comprehension

    ERIC Educational Resources Information Center

    Hodds, Mark; Alcock, Lara; Inglis, Matthew

    2014-01-01

    In this article we report 3 experiments demonstrating that a simple booklet containing self-explanation training, designed to focus students' attention on logical relationships within a mathematical proof, can significantly improve their proof comprehension. Experiment 1 demonstrated that students who received the training generated higher quality…

  4. How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy?

    PubMed

    Yuen, Eunice S M; Sims, John R

    2014-06-01

    Human photosensitive epilepsy models have been used as proof of principle (POP) trials for epilepsy. Photosensitive patients are exposed to intermittent photic stimulation and the reduction in sensitivity to the number of standard visual stimulation frequencies is used as an endpoint. The aim of this research was to quantify the predictive capabilities of photosensitive POP trials, through a survey of current literature. A literature search was undertaken to identify articles describing photosensitive POP trials. Minimally efficacious doses (MEDs) in epilepsy were compared to doses in the POP trials that produced 50-100% response (ED50-100). Ratios of these doses were calculated and summarised statistically. The search identified ten articles describing a total of 17 anti-epileptic drugs. Of these, data for both MED and ED50-100 were available for 13 anti-epileptic drugs. The average ratio of MED to ED50-100 was 0.95 (95% CI 0.60-1.30). The difference in MED to ED50-100 ratios between partial epilepsy (0.82) was not significantly different from that of generalised epilepsy (1.08) (p=0.51). Photosensitive POP trials are a useful tool to quantitatively predict efficacy in epilepsy, and can be useful as early and informative indicators in anti-epileptic drug discovery and development. Copyright © 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  5. Plasma wakefield acceleration experiments at FACET II

    NASA Astrophysics Data System (ADS)

    Joshi, C.; Adli, E.; An, W.; Clayton, C. E.; Corde, S.; Gessner, S.; Hogan, M. J.; Litos, M.; Lu, W.; Marsh, K. A.; Mori, W. B.; Vafaei-Najafabadi, N.; O'shea, B.; Xu, Xinlu; White, G.; Yakimenko, V.

    2018-03-01

    During the past two decades of research, the ultra-relativistic beam-driven plasma wakefield accelerator (PWFA) concept has achieved many significant milestones. These include the demonstration of ultra-high gradient acceleration of electrons over meter-scale plasma accelerator structures, efficient acceleration of a narrow energy spread electron bunch at high-gradients, positron acceleration using wakes in uniform plasmas and in hollow plasma channels, and demonstrating that highly nonlinear wakes in the ‘blow-out regime’ have the electric field structure necessary for preserving the emittance of the accelerating bunch. A new 10 GeV electron beam facility, Facilities for Accelerator Science and Experimental Test (FACET) II, is currently under construction at SLAC National Accelerator Laboratory for the next generation of PWFA research and development. The FACET II beams will enable the simultaneous demonstration of substantial energy gain of a small emittance electron bunch while demonstrating an efficient transfer of energy from the drive to the trailing bunch. In this paper we first describe the capabilities of the FACET II facility. We then describe a series of PWFA experiments supported by numerical and particle-in-cell simulations designed to demonstrate plasma wake generation where the drive beam is nearly depleted of its energy, high efficiency acceleration of the trailing bunch while doubling its energy and ultimately, quantifying the emittance growth in a single stage of a PWFA that has optimally designed matching sections. We then briefly discuss other FACET II plasma-based experiments including in situ positron generation and acceleration, and several schemes that are promising for generating sub-micron emittance bunches that will ultimately be needed for both an early application of a PWFA and for a plasma-based future linear collider.

  6. Plasma wakefield acceleration experiments at FACET II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joshi, C.; Adli, E.; An, W.

    During the past two decades of research, the ultra-relativistic beam-driven plasma wakefield accelerator (PWFA) concept has achieved many significant milestones. These include the demonstration of ultra-high gradient acceleration of electrons over meter-scale plasma accelerator structures, efficient acceleration of a narrow energy spread electron bunch at high-gradients, positron acceleration using wakes in uniform plasmas and in hollow plasma channels, and demonstrating that highly nonlinear wakes in the 'blow-out regime' have the electric field structure necessary for preserving the emittance of the accelerating bunch. A new 10 GeV electron beam facility, Facilities for Accelerator Science and Experimental Test (FACET) II, is currentlymore » under construction at SLAC National Accelerator Laboratory for the next generation of PWFA research and development. The FACET II beams will enable the simultaneous demonstration of substantial energy gain of a small emittance electron bunch while demonstrating an efficient transfer of energy from the drive to the trailing bunch. In this paper we first describe the capabilities of the FACET II facility. We then describe a series of PWFA experiments supported by numerical and particle-in-cell simulations designed to demonstrate plasma wake generation where the drive beam is nearly depleted of its energy, high efficiency acceleration of the trailing bunch while doubling its energy and ultimately, quantifying the emittance growth in a single stage of a PWFA that has optimally designed matching sections. Here, we briefly discuss other FACET II plasma-based experiments including in situ positron generation and acceleration, and several schemes that are promising for generating sub-micron emittance bunches that will ultimately be needed for both an early application of a PWFA and for a plasma-based future linear collider.« less

  7. Plasma wakefield acceleration experiments at FACET II

    DOE PAGES

    Joshi, C.; Adli, E.; An, W.; ...

    2018-01-12

    During the past two decades of research, the ultra-relativistic beam-driven plasma wakefield accelerator (PWFA) concept has achieved many significant milestones. These include the demonstration of ultra-high gradient acceleration of electrons over meter-scale plasma accelerator structures, efficient acceleration of a narrow energy spread electron bunch at high-gradients, positron acceleration using wakes in uniform plasmas and in hollow plasma channels, and demonstrating that highly nonlinear wakes in the 'blow-out regime' have the electric field structure necessary for preserving the emittance of the accelerating bunch. A new 10 GeV electron beam facility, Facilities for Accelerator Science and Experimental Test (FACET) II, is currentlymore » under construction at SLAC National Accelerator Laboratory for the next generation of PWFA research and development. The FACET II beams will enable the simultaneous demonstration of substantial energy gain of a small emittance electron bunch while demonstrating an efficient transfer of energy from the drive to the trailing bunch. In this paper we first describe the capabilities of the FACET II facility. We then describe a series of PWFA experiments supported by numerical and particle-in-cell simulations designed to demonstrate plasma wake generation where the drive beam is nearly depleted of its energy, high efficiency acceleration of the trailing bunch while doubling its energy and ultimately, quantifying the emittance growth in a single stage of a PWFA that has optimally designed matching sections. Here, we briefly discuss other FACET II plasma-based experiments including in situ positron generation and acceleration, and several schemes that are promising for generating sub-micron emittance bunches that will ultimately be needed for both an early application of a PWFA and for a plasma-based future linear collider.« less

  8. Narrative Constructions for the Organization of Self Experience: Proof of Concept via Embodied Robotics.

    PubMed

    Mealier, Anne-Laure; Pointeau, Gregoire; Mirliaz, Solène; Ogawa, Kenji; Finlayson, Mark; Dominey, Peter F

    2017-01-01

    It has been proposed that starting from meaning that the child derives directly from shared experience with others, adult narrative enriches this meaning and its structure, providing causal links between unseen intentional states and actions. This would require a means for representing meaning from experience-a situation model-and a mechanism that allows information to be extracted from sentences and mapped onto the situation model that has been derived from experience, thus enriching that representation. We present a hypothesis and theory concerning how the language processing infrastructure for grammatical constructions can naturally be extended to narrative constructions to provide a mechanism for using language to enrich meaning derived from physical experience. Toward this aim, the grammatical construction models are augmented with additional structures for representing relations between events across sentences. Simulation results demonstrate proof of concept for how the narrative construction model supports multiple successive levels of meaning creation which allows the system to learn about the intentionality of mental states, and argument substitution which allows extensions to metaphorical language and analogical problem solving. Cross-linguistic validity of the system is demonstrated in Japanese. The narrative construction model is then integrated into the cognitive system of a humanoid robot that provides the memory systems and world-interaction required for representing meaning in a situation model. In this context proof of concept is demonstrated for how the system enriches meaning in the situation model that has been directly derived from experience. In terms of links to empirical data, the model predicts strong usage based effects: that is, that the narrative constructions used by children will be highly correlated with those that they experience. It also relies on the notion of narrative or discourse function words. Both of these are validated in

  9. Dynamic PROOF clusters with PoD: architecture and user experience

    NASA Astrophysics Data System (ADS)

    Manafov, Anar

    2011-12-01

    PROOF on Demand (PoD) is a tool-set, which sets up a PROOF cluster on any resource management system. PoD is a user oriented product with an easy to use GUI and a command-line interface. It is fully automated. No administrative privileges or special knowledge is required to use it. PoD utilizes a plug-in system, to use different job submission front-ends. The current PoD distribution is shipped with LSF, Torque (PBS), Grid Engine, Condor, gLite, and SSH plug-ins. The product is to be extended. We therefore plan to implement a plug-in for AliEn Grid as well. Recently developed algorithms made it possible to efficiently maintain two types of connections: packet-forwarding and native PROOF connections. This helps to properly handle most kinds of workers, with and without firewalls. PoD maintains the PROOF environment automatically and, for example, prevents resource misusage in case when workers idle for too long. As PoD matures as a product and provides more plug-ins, it's used as a standard for setting up dynamic PROOF clusters in many different institutions. The GSI Analysis Facility (GSIAF) is in production since 2007. The static PROOF cluster has been phased out end of 2009. GSIAF is now completely based on PoD. Users create private dynamic PROOF clusters on the general purpose batch farm. This provides an easier resource sharing between interactive local batch and Grid usage. The main user communities are FAIR and ALICE.

  10. Families of Functions and Functions of Proof

    ERIC Educational Resources Information Center

    Landman, Greisy Winicki

    2002-01-01

    This article describes an activity for secondary school students that may constitute an appropriate opportunity to discuss with them the idea of proof, particularly in an algebraic context. During the activity the students may experience and understand some of the roles played by proof in mathematics in addition to verification of truth:…

  11. Infrared laser induced population transfer and parity selection in {sup 14}NH{sub 3}: A proof of principle experiment towards detecting parity violation in chiral molecules

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dietiker, P.; Miloglyadov, E.; Quack, M., E-mail: Martin@Quack.ch

    We have set up an experiment for the efficient population transfer by a sequential two photon—absorption and stimulated emission—process in a molecular beam to prepare quantum states of well defined parity and their subsequent sensitive detection. This provides a proof of principle for an experiment which would allow for parity selection and measurement of the time evolution of parity in chiral molecules, resulting in a measurement of the parity violating energy difference Δ{sub pv}E between enantiomers of chiral molecules. Here, we present first results on a simple achiral molecule demonstrating efficient population transfer (about 80% on the average for eachmore » step) and unperturbed persistence of a selected excited parity level over flight times of about 1.3 ms in the beam. In agreement with model calculations with and without including nuclear hyperfine structure, efficient population transfer can be achieved by a rather simple implementation of the rapid adiabatic passage method of Reuss and coworkers and considering also the stimulated Raman adiabatic passage technique of Bergmann and coworkers as an alternative. The preparation step uses two powerful single mode continuous wave optical parametric oscillators of high frequency stability and accuracy. The detection uses a sensitive resonantly enhanced multiphoton ionization method after free flight lengths of up to 0.8 m in the molecular beam. Using this technique, we were able to also resolve the nuclear hyperfine structure in the rovibrational levels of the ν{sub 1} and ν{sub 3} fundamentals as well as the 2ν{sub 4} overtone of {sup 14}NH{sub 3}, for which no previous data with hyperfine resolution were available. We present our new results on the quadrupole coupling constants for the ν{sub 1}, ν{sub 3}, and 2ν{sub 4} levels in the context of previously known data for ν{sub 2} and its overtone, as well as ν{sub 4}, and the ground state. Thus, now, {sup 14}N quadrupole coupling constants for

  12. A variable acceleration calibration system

    NASA Astrophysics Data System (ADS)

    Johnson, Thomas H.

    2011-12-01

    A variable acceleration calibration system that applies loads using gravitational and centripetal acceleration serves as an alternative, efficient and cost effective method for calibrating internal wind tunnel force balances. Two proof-of-concept variable acceleration calibration systems are designed, fabricated and tested. The NASA UT-36 force balance served as the test balance for the calibration experiments. The variable acceleration calibration systems are shown to be capable of performing three component calibration experiments with an approximate applied load error on the order of 1% of the full scale calibration loads. Sources of error are indentified using experimental design methods and a propagation of uncertainty analysis. Three types of uncertainty are indentified for the systems and are attributed to prediction error, calibration error and pure error. Angular velocity uncertainty is shown to be the largest indentified source of prediction error. The calibration uncertainties using a production variable acceleration based system are shown to be potentially equivalent to current methods. The production quality system can be realized using lighter materials and a more precise instrumentation. Further research is needed to account for balance deflection, forcing effects due to vibration, and large tare loads. A gyroscope measurement technique is shown to be capable of resolving the balance deflection angle calculation. Long term research objectives include a demonstration of a six degree of freedom calibration, and a large capacity balance calibration.

  13. Accelerator/Experiment Operations - FY 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Czarapata, P.

    2015-10-01

    This Technical Memorandum summarizes the Fermilab accelerator and experiment operations for FY 2015. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2015 NOvA, MINOS+ and MINERvA experiments using the Main Injector Neutrino Beam (NuMI), the activities in the SciBooNE Hall using the Booster Neutrino Beam (BNB), and the SeaQuest experiment and Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120).

  14. Acceleration technologies for charged particles: an introduction

    NASA Astrophysics Data System (ADS)

    Carter, Richard G.

    2011-01-01

    Particle accelerators have many important uses in scientific experiments, in industry and in medicine. This paper reviews the variety of technologies which are used to accelerate charged particles to high energies. It aims to show how the capabilities and limitations of these technologies are related to underlying physical principles. The paper emphasises the way in which different technologies are used together to convey energy from the electrical supply to the accelerated particles.

  15. Narrative Constructions for the Organization of Self Experience: Proof of Concept via Embodied Robotics

    PubMed Central

    Mealier, Anne-Laure; Pointeau, Gregoire; Mirliaz, Solène; Ogawa, Kenji; Finlayson, Mark; Dominey, Peter F.

    2017-01-01

    It has been proposed that starting from meaning that the child derives directly from shared experience with others, adult narrative enriches this meaning and its structure, providing causal links between unseen intentional states and actions. This would require a means for representing meaning from experience—a situation model—and a mechanism that allows information to be extracted from sentences and mapped onto the situation model that has been derived from experience, thus enriching that representation. We present a hypothesis and theory concerning how the language processing infrastructure for grammatical constructions can naturally be extended to narrative constructions to provide a mechanism for using language to enrich meaning derived from physical experience. Toward this aim, the grammatical construction models are augmented with additional structures for representing relations between events across sentences. Simulation results demonstrate proof of concept for how the narrative construction model supports multiple successive levels of meaning creation which allows the system to learn about the intentionality of mental states, and argument substitution which allows extensions to metaphorical language and analogical problem solving. Cross-linguistic validity of the system is demonstrated in Japanese. The narrative construction model is then integrated into the cognitive system of a humanoid robot that provides the memory systems and world-interaction required for representing meaning in a situation model. In this context proof of concept is demonstrated for how the system enriches meaning in the situation model that has been directly derived from experience. In terms of links to empirical data, the model predicts strong usage based effects: that is, that the narrative constructions used by children will be highly correlated with those that they experience. It also relies on the notion of narrative or discourse function words. Both of these are validated

  16. Linear Proof-Mass Actuator

    NASA Technical Reports Server (NTRS)

    Holloway, Sidney E., III; Crossley, Edward A.; Miller, James B.; Jones, Irby W.; Davis, C. Calvin; Behun, Vaughn D.; Goodrich, Lewis R., Sr.

    1995-01-01

    Linear proof-mass actuator (LPMA) is friction-driven linear mass actuator capable of applying controlled force to structure in outer space to damp out oscillations. Capable of high accelerations and provides smooth, bidirectional travel of mass. Design eliminates gears and belts. LPMA strong enough to be used terrestrially where linear actuators needed to excite or damp out oscillations. High flexibility designed into LPMA by varying size of motors, mass, and length of stroke, and by modifying control software.

  17. Compact Torus Acceleration and Injection Experiment

    NASA Astrophysics Data System (ADS)

    Fukumoto, Naoyuki; Fujiwara, Makoto; Nagata, Masayoshi; Uyama, Tadao; Oda, Yasushi; Azuma, Kingo

    1996-11-01

    The spheromak-type compact torus (CT) acceleration and injection experiment has been carried out using the Himeji Institute of Technology Compact Torus Injector (HIT-CTI). We explore the possibility of refueling, density control, current drive, and edge electric field control of tokamak plasma by means of CT injection. In last September the new HIT-CTI was built up to achieve higher speed (Vct>200 km/s) and higher density CT plasmoid by improving the capacitor bank system and eliminating the impurity and neutral particles. At initial formation discharge tests the gun for formation and compression successfully produced a CT plasmoid and injected it between electrodes for acceleration. (Initial velocity Vct.ini. 32 km/s, Bct 1 kG, Rct=5.5 cm). The formation capacitor bank will be upgraded to two 36 mF capacitors operating at 20 kV (14.4 kJ). The acceleration capacitor bank will be also upgraded to two 36 mF capacitors operating at 20 kV (14.4 kJ). The HIT-CTI will be optimized to obtain suitable CT parameters after acceleration (Bct>5 kG, Lct 20 cm, Vct>200 km/s). In the respect of CT parameter measurement magnetic probes and a He-Ne laser interferometer will be employed in order to measure the CT magnetic field, velocity, density, and length. CT acceleration experimental data on the HIT-CTI and the plan of CT injection experiment on the JFT-2M tokamak (JAERI) will be presented at the meeting.

  18. Accelerator/Experiment Operations - FY 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blake, A.; Convery, M.; Geer, S.

    2016-10-01

    This Technical Memorandum summarizes the Fermilab accelerator and experiment operations for FY 2016. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2016 NOvA, MINOS+ and MINERvA experiments using the Main Injector Neutrino Beam (NuMI), the MicroBooNE experiment and the activities in the SciBooNE Hall using the Booster Neutrino Beam (BNB), and the SeaQuest experiment, LArIAT experiment and Meson Test Beam activities in the 120 GeV external switchyard beam (SY120). Each section was prepared by the relevant authors, and was then edited for inclusion inmore » this summary.« less

  19. Conceptual design and proof-of-principle testing of the real-time multispectral imaging system MANTIS

    NASA Astrophysics Data System (ADS)

    Vijvers, W. A. J.; Mumgaard, R. T.; Andrebe, Y.; Classen, I. G. J.; Duval, B. P.; Lipschultz, B.

    2017-12-01

    The Multispectral Advanced Narrowband Tokamak Imaging System (MANTIS) is proposed to resolve the steep temperature and density gradients in the scrape-off layer of tokamaks in real-time. The initial design is to deliver two-dimensional distributions of key plasma parameters of the TCV tokamak to a real-time control system in order to enable novel control strategies, while providing new insights into power exhaust physics in the full offline analysis. This paper presents the conceptual system design, the mechanical and optical design of a prototype that was built to assess the optical performance, and the results of the first proof-of-principle tests of the prototype. These demonstrate a central resolving power of 50-46 line pairs per millimeter (CTF50) in the first four channels. For the additional channels, the sharpness is a factor two worse for the odd channels (likely affected by sub-optimal alignment), while the even channels continue the trend observed for the first four channels of 3% degradation per channel. This is explained by the self-cancellation of off-axis aberrations, which is an attractive property of the chosen optical design. The results show that at least a 10-channel real-time multispectral imaging system is feasible.

  20. Quantification of the Robusta fraction in a coffee blend via Raman spectroscopy: proof of principle.

    PubMed

    Wermelinger, Thomas; D'Ambrosio, Lucio; Klopprogge, Babette; Yeretzian, Chahan

    2011-09-14

    Among the 100 different known Coffea species, Coffea arabica L. (Arabica) and Coffea canephora Pierre (Robusta) are the only two of commercial interest. They differ in a range of agronomic, genetic, and chemical properties. Due to the significant price difference between Arabica and Robusta, there is an economic incentive to illicitly replace Arabica with Robusta. Therefore, it is crucial to have accurate methods to determine the Robusta-to-Arabica-ratio in blends. This paper presents the proof of principle of a new and fast approach to determine the Robusta fraction in a blend based on Raman spectroscopy. The oils of two references (a pure Robusta and pure Arabica coffee) and six blends thereof consisting of different Robusta and Arabica fractions were extracted using a Soxhlet system. The solutes were analyzed by means of Raman spectroscopy without further workup. Using the intensity ratio between two Raman peaks, one characteristic for kahweol and one characteristic for fatty acids, allowed determinination of the Robusta content in a given mixture. The intensity ratio is linearly dependent on the Robusta content of the compound. Above a Robusta content of 75 wt %, kahweol was not detectable. The Raman data are in agreement with results obtained from the very time-consuming multistep DIN 10777 procedures based on HPLC.

  1. Characterizing near-surface elemental layering on Mars using gamma-ray spectroscopy: A proof-of-principle experiment

    NASA Astrophysics Data System (ADS)

    Peplowski, Patrick N.; Wilson, Jack T.; Beck, Andrew W.; Burks, Morgan; Goldsten, John O.; Lawrence, David J.

    2018-01-01

    Gamma-ray spectroscopy investigations characterize the chemical composition of planetary surfaces by measuring element-characteristic gamma rays with energies of ∼100 keV to ∼9 MeV. Over this energy range, the mean free path of a gamma ray varies from about 1 to 25 cm, therefore gamma-ray measurements sample subsurface composition. Many elements emit gamma rays at multiple, often widely spaced energies, so gamma-ray measurements can in principle also be used to identify depth-dependent variations in subsurface composition. We report results from laboratory measurements and radiation transport modeling designed to demonstrate this capability. The laboratory measurements verified the presence of depth-dependent gamma-ray signatures, and were then used to benchmark radiation transport simulations that were used to model realistic Mars-like scenarios. The models indicate that compositionally distinct subsurface deposits, buried to depths of ∼80 cm (125 g/cm2), can be identified using gamma-ray measurements. Going beyond identification to characterization (burial depth, relative composition of the layers) of the deposits requires knowledge of the vertical and horizontal variability in the water content of the near-surface surface materials, the local Galactic Cosmic Ray environment (magnitude and energy distribution), the depth-dependent neutron flux, gamma-ray production cross sections, and knowledge of the composition and column density of the atmosphere. The results of our experiments and models provided a basis for examining the utility of using orbiter- and lander-based gamma-ray measurements to identify subsurface deposits on Mars.

  2. Japanese Logic Puzzles and Proof

    ERIC Educational Resources Information Center

    Wanko, Jeffrey J.

    2009-01-01

    An understanding of proof does not start in a high school geometry course. Rather, attention to logical reasoning throughout a student's school experience can help the development of proof readiness. In the spirit of problem solving, the author has begun to use some Japanese logic puzzles other than sudoku to help students develop additional…

  3. Design Considerations of a Novel Two-Beam Accelerator

    NASA Astrophysics Data System (ADS)

    Luginsland, John William

    This thesis reports the design study of a new type of charged particle accelerator called the Twobetron. The accelerator consists of two beams of electrons traveling through a series of pillbox cavities. The power of a high current annular beam excites an electromagnetic mode in the cavities, which, in turn, drives a low current on-axis pencil beam to high energy. We focus on the design considerations that would make use of existing pulsed power systems, for a proof-of-principle experiment. Potential applications of this new device include radiotherapy, materials processing, and high energy accelerators. The first phase of the research involves analytic description of the accelerating process. This reveals the problem of phase slippage. Derbenev's proposed cure of beam radius modulation is analyzed. Further studies include the effect of initial phase and secondary beam loading. Scaling laws to characterize the Twobetron's performance are derived. Computer simulation is performed to produce a self-consistent analysis of the dynamics of the space charge and its interaction with the accelerator structure. Particle -in-cell simulations answer several questions concerning beam stability, cavity modes, and the nature of the structure. Specifically, current modulation on the primary beam is preserved in the simulations. However, these simulations also revealed that mode competition and significant cavity coupling are serious issues that need to be addressed. Also considered is non-axisymmetric instability on the driver beam of the Twobetron, in particular, the beam breakup instability (BBU), which is known to pose a serious threat to linear accelerators in general. We extend the classical analysis of BBU to annular beams. The effect of higher order non-axisymmetric modes is also examined. It is shown that annular beams are more stable than pencil beams to BBU in general. Our analysis also reveals that the rf magnetic field is more important than the rf electric field in

  4. Interpretation of Mössbauer experiment in a rotating system: A new proof for general relativity

    NASA Astrophysics Data System (ADS)

    Corda, Christian

    2015-04-01

    A historical experiment by Kündig on the transverse Doppler shift in a rotating system measured with the Mössbauer effect (Mössbauer rotor experiment) has been recently first re-analyzed and then replied by an experimental research group. The results of re-analyzing the experiment have shown that a correct re-processing of Kündig's experimental data gives an interesting deviation of a relative redshift between emission and absorption resonant lines from the standard prediction based on the relativistic dilatation of time. That prediction gives a redshift ∇E/E ≃ -1/2 v2/c2 where v is the tangential velocity of the absorber of resonant radiation, c is the velocity of light in vacuum and the result is given to the accuracy of first-order in v2/c2. Data re-processing gave ∇E/E ≃ - kv2/c2 with k = 0.596 ± 0.006. Subsequent new experimental results by the reply of Kündig experiment have shown a redshift with k = 0.68 ± 0.03 instead. By using Einstein Equivalence Principle, which states the equivalence between the gravitational "force" and the pseudo-force experienced by an observer in a non-inertial frame of reference (included a rotating frame of reference) here we re-analyze the theoretical framework of Mössbauer rotor experiments directly in the rotating frame of reference by using a general relativistic treatment. It will be shown that previous analyses missed an important effect of clock synchronization and that the correct general relativistic prevision in the rotating frame gives k ≃ 2/3 in perfect agreement with the new experimental results. Such an effect of clock synchronization has been missed in various papers in the literature with some subsequent claim of invalidity of relativity theory and/or some attempts to explain the experimental results through "exotic" effects. Our general relativistic interpretation shows, instead, that the new experimental results of the Mössbauer rotor experiment are a new, strong and independent, proof of

  5. Ten Things to Consider when Teaching Proof

    ERIC Educational Resources Information Center

    Cirillo, Michelle

    2009-01-01

    As she sat in a high school geometry class and observed a beginning teacher, Matt (a pseudonym), teaching proof for the first time, the author was reminded of her own experiences in teaching formal proof to secondary school students. Matt seemed to struggle with some of the same challenges she encountered when she began teaching proof. For…

  6. NMR-Based Serum Metabolomics Discriminates Takayasu Arteritis from Healthy Individuals: A Proof-of-Principle Study.

    PubMed

    Guleria, Anupam; Misra, Durga Prasanna; Rawat, Atul; Dubey, Durgesh; Khetrapal, Chunni Lal; Bacon, Paul; Misra, Ramnath; Kumar, Dinesh

    2015-08-07

    Takayasu arteritis (TA) is a debilitating, systemic disease that involves the aorta and large arteries in a chronic inflammatory process that leads to vessel stenosis. Initially, the disease remains clinically silent (or remains undetected) until the patients present with vascular occlusion. Therefore, new methods for appropriate and timely diagnosis of TA cases are needed to start proper therapy on time and also to monitor the patient's response to the given treatment. In this context, NMR-based serum metabolomic profiling has been explored in this proof-of-principle study for the first time to determine characteristic metabolites that could be potentially helpful for diagnosis and prognosis of TA. Serum metabolic profiling of TA patients (n = 29) and healthy controls (n = 30) was performed using 1D (1)H NMR spectroscopy, and possible biomarker metabolites were identified. Using projection to least-squares discriminant analysis, we could distinguish TA patients from healthy controls. Compared to healthy controls, TA patients had (a) increased serum levels of choline metabolites, LDL cholesterol, N-acetyl glycoproteins (NAGs), and glucose and (b) decreased serum levels of lactate, lipids, HDL cholesterol, and glucogenic amino acids. The results of this study are preliminary and need to be confirmed in a prospective study.

  7. Numerical and Experimental Investigation of the Effects of Acceleration Disturbances on Microgravity Experiments

    NASA Technical Reports Server (NTRS)

    Ramachandran, Narayanan

    2000-01-01

    Normal vibrational modes on large spacecraft are excited by crew activity, operating machinery, and other mechanical disturbances. Periodic engine burns for maintaining vehicle attitude and random impulse type disturbances also contribute to the acceleration environment of a Spacecraft. Accelerations from these vibrations (often referred to as g-jitter) are several orders of magnitude larger than the residual accelerations from atmospheric drag and gravity gradient effects. Naturally, the effects of such accelerations have been a concern to prospective experimenters wishing to take advantage of the microgravity environment offered by spacecraft operating in low Earth orbit and the topic has been studied extensively, both numerically and analytically. However, these studies have not produced a general theory that predicts the effects of multi-spectral periodic accelerations on a general class of experiments nor have they produced scaling laws that a prospective experimenter could use to assess how his/her experiment might be affected by this acceleration environment. Furthermore, there are no actual flight experimental data that correlates heat or mass transport with measurements of the periodic acceleration environment. The present investigation approaches this problem with carefully conducted terrestrial experiments and rigorous numerical modeling thereby providing comparative theoretical and experimental data. The modeling, it is hoped will provide a predictive tool that can be used for assessing experiment response to Spacecraft vibrations.

  8. Voluntary control of corticomuscular coherence through neurofeedback: a proof-of-principle study in healthy subjects.

    PubMed

    von Carlowitz-Ghori, K; Bayraktaroglu, Z; Waterstraat, G; Curio, G; Nikulin, V V

    2015-04-02

    Corticomuscular coherence (CMC) relates to synchronization between activity in the motor cortex and the muscle activity. The strength of CMC can be affected by motor behavior. In a proof-of-principle study, we examined whether independent of motor output parameters, healthy subjects are able to voluntarily modulate CMC in a neurofeedback paradigm. Subjects received visual online feedback of their instantaneous CMC strength, which was calculated between an optimized spatial projection of multichannel electroencephalography (EEG) and electromyography (EMG) in an individually defined target frequency range. The neurofeedback training consisted of either increasing or decreasing CMC strength using a self-chosen mental strategy while performing a simple motor task. Evaluation of instantaneous coherence showed that CMC strength was significantly larger when subjects had to increase than when to decrease CMC; this difference between the two task conditions did not depend on motor performance. The exclusion of confounding factors such as motor performance, attention and task complexity in study design provides evidence that subjects were able to voluntarily modify CMC independent of motor output parameters. Additional analysis further strengthened the assumption that the subjects' response was specifically shaped by the neurofeedback. In perspective, we suggest that CMC-based neurofeedback could provide a therapeutic approach in clinical conditions, such as motor stroke, where CMC is altered. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  9. Space experiments with particle accelerators (SEPAC): Description of instrumentation

    NASA Technical Reports Server (NTRS)

    Taylor, W. W. L.; Roberts, W. T.; Reasoner, D. L.; Chappell, C. R.; Baker, B. B.; Burch, J. L.; Gibson, W. C.; Black, R. K.; Tomlinson, W. M.; Bounds, J. R.

    1987-01-01

    SEPAC (Space Experiments with Particle Accelerators) flew on Spacelab 1 (SL 1) in November and December 1983. SEPAC is a joint U.S.-Japan investigation of the interaction of electron, plasma, and neutral beams with the ionosphere, atmosphere and magnetosphere. It is scheduled to fly again on Atlas 1 in August 1990. On SL 1, SEPAC used an electron accelerator, a plasma accelerator, and neutral gas source as active elements and an array of diagnostics to investigate the interactions. For Atlas 1, the plasma accelerator will be replaced by a plasma contactor and charge collection devices to improve vehicle charging meutralization. This paper describes the SEPAC instrumentation in detail for the SL 1 and Atlas 1 flights and includes a bibliography of SEPAC papers.

  10. TU-CD-BRA-08: Single-Energy Computed Tomography-Based Pulmonary Perfusion Imaging: Proof-Of-Principle in a Canine Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yamamoto, T; Boone, J; Kent, M

    Purpose: Pulmonary perfusion imaging has provided significant insights into pulmonary diseases, and can be useful in radiotherapy. The purpose of this study was to prospectively establish proof-of-principle in a canine model for single-energy CT-based perfusion imaging, which has the potential for widespread clinical implementation. Methods: Single-energy CT perfusion imaging is based on: (1) acquisition of inspiratory breath-hold CT scans before and after intravenous injection of iodinated contrast medium, (2) deformable image registration (DIR) of the two CT image data sets, and (3) subtraction of the pre-contrast image from post-contrast image, yielding a map of Hounsfield unit (HU) enhancement. These subtractionmore » image data sets hypothetically represent perfused blood volume, a surrogate for perfusion. In an IACUC-approved clinical trial, we acquired pre- and post-contrast CT scans in the prone posture for six anesthetized, mechanically-ventilated dogs. The elastix algorithm was used for DIR. The registration accuracy was quantified using the target registration errors (TREs) for 50 pulmonary landmarks in each dog. The gradient of HU enhancement between gravity-dependent (ventral) and non-dependent (dorsal) regions was evaluated to quantify the known effect of gravity, i.e., greater perfusion in ventral regions. Results: The lung volume difference between the two scans was 4.3±3.5% on average (range 0.3%–10.1%). DIR demonstrated an average TRE of 0.7±1.0 mm. HU enhancement in lung parenchyma was 34±10 HU on average and varied considerably between individual dogs, indicating the need for improvement of the contrast injection protocol. HU enhancement in ventral (gravity-dependent) regions was found to be greater than in dorsal regions. A population average ventral-to-dorsal gradient of HU enhancement was strong (R{sup 2}=0.94) and statistically significant (p<0.01). Conclusion: This canine study demonstrated relatively accurate DIR and a strong

  11. On the superposition principle in interference experiments.

    PubMed

    Sinha, Aninda; H Vijay, Aravind; Sinha, Urbasi

    2015-05-14

    The superposition principle is usually incorrectly applied in interference experiments. This has recently been investigated through numerics based on Finite Difference Time Domain (FDTD) methods as well as the Feynman path integral formalism. In the current work, we have derived an analytic formula for the Sorkin parameter which can be used to determine the deviation from the application of the principle. We have found excellent agreement between the analytic distribution and those that have been earlier estimated by numerical integration as well as resource intensive FDTD simulations. The analytic handle would be useful for comparing theory with future experiments. It is applicable both to physics based on classical wave equations as well as the non-relativistic Schrödinger equation.

  12. GPU acceleration of the Locally Selfconsistent Multiple Scattering code for first principles calculation of the ground state and statistical physics of materials

    NASA Astrophysics Data System (ADS)

    Eisenbach, Markus; Larkin, Jeff; Lutjens, Justin; Rennich, Steven; Rogers, James H.

    2017-02-01

    The Locally Self-consistent Multiple Scattering (LSMS) code solves the first principles Density Functional theory Kohn-Sham equation for a wide range of materials with a special focus on metals, alloys and metallic nano-structures. It has traditionally exhibited near perfect scalability on massively parallel high performance computer architectures. We present our efforts to exploit GPUs to accelerate the LSMS code to enable first principles calculations of O(100,000) atoms and statistical physics sampling of finite temperature properties. We reimplement the scattering matrix calculation for GPUs with a block matrix inversion algorithm that only uses accelerator memory. Using the Cray XK7 system Titan at the Oak Ridge Leadership Computing Facility we achieve a sustained performance of 14.5PFlop/s and a speedup of 8.6 compared to the CPU only code.

  13. Debate-Proof Grades: Experiences and Challenges of Using a Grading Rubric in a Social Welfare Policy Course

    ERIC Educational Resources Information Center

    Adedoyin, Christson A.

    2013-01-01

    This article discusses the experiences and challenges of a graduate teaching assistant in using a grading rubric in a social welfare policy course. Using a grading rubric as a debate-proof strategy against the grade entitlement of students is expatiated. In addition, the benefits of using grading rubrics to achieve CSWE/EPAS competency…

  14. Accelerated approval of oncology products: a decade of experience.

    PubMed

    Dagher, Ramzi; Johnson, John; Williams, Grant; Keegan, Patricia; Pazdur, Richard

    2004-10-20

    We review the regulatory history of the accelerated approval process and summarize the U.S. Food and Drug Administration experience with accelerated approvals in oncology. The accelerated approval regulations, promulgated in 1992, allow approval of drugs for serious or life-threatening diseases on the basis of a surrogate endpoint that is reasonably likely to predict clinical benefit, such as survival or symptom benefit, pending completion of studies designed to confirm clinical benefit, referred to as phase 4 commitments, which are required to be conducted with due diligence. From 1992 to 2004, 22 applications involving anticancer drugs or biologics were approved. Of these 22 applications, accelerated approval was granted to 15 on the basis of findings from studies without an active comparator (i.e., single-arm studies or studies comparing two dose levels) and to the remaining seven on the basis of one or more randomized studies. Of the 22 approved applications, six (i.e., applications for dexrazoxane, irinotecan, capecitabine, docetaxel, imatinib mesylate, and oxaliplatin) have had one or more indications converted to regular approval. This review reports information that was presented at an Oncologic Drugs Advisory Committee meeting held in March 2003; it also presents a discussion of accelerated approval study designs, the study populations evaluated in the accelerated approval and confirmatory settings, and the integration of accelerated approval into a comprehensive drug development plan.

  15. Ultrashort laser pulse driven inverse free electron laser accelerator experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moody, J. T.; Anderson, S. G.; Anderson, G.

    In this paper we discuss the ultrashort pulse high gradient Inverse Free Electron laser accelerator experiment carried out at the Lawrence Livermore National Laboratory which demonstrated gra- dients exceeding 200 MV/m using a 4 TW 100 fs long 800 nm Ti:Sa laser pulse. Due to the short laser and electron pulse lengths, synchronization was determined to be one of the main challenges in this experiment. This made necessary the implementation of a single-shot, non destructive, electro-optic sampling based diagnostics to enable time-stamping of each laser accelerator shot with < 100 fs accuracy. The results of this experiment are expected tomore » pave the way towards the development of future GeV-class IFEL accelerators.« less

  16. Ultrashort laser pulse driven inverse free electron laser accelerator experiment

    DOE PAGES

    Moody, J. T.; Anderson, S. G.; Anderson, G.; ...

    2016-02-29

    In this paper we discuss the ultrashort pulse high gradient Inverse Free Electron laser accelerator experiment carried out at the Lawrence Livermore National Laboratory which demonstrated gra- dients exceeding 200 MV/m using a 4 TW 100 fs long 800 nm Ti:Sa laser pulse. Due to the short laser and electron pulse lengths, synchronization was determined to be one of the main challenges in this experiment. This made necessary the implementation of a single-shot, non destructive, electro-optic sampling based diagnostics to enable time-stamping of each laser accelerator shot with < 100 fs accuracy. The results of this experiment are expected tomore » pave the way towards the development of future GeV-class IFEL accelerators.« less

  17. Milk sweetened with xylitol: a proof-of-principle caries prevention randomized clinical trial

    PubMed Central

    Chi, Donald L.; Zegarra, Graciela; Vasquez Huerta, Elsa C.; Castillo, Jorge L.; Milgrom, Peter; Roberts, Marilyn C.; Cabrera Matta, Ailin R.; Mancl, Lloyd; Merino, Ana P.

    2016-01-01

    Purpose To evaluate the efficacy of xylitol-sweetened milk as a caries preventive strategy. Methods In this nine-month prospective proof-of-principle trial, 153 Peruvian school children Peru were randomized to a milk group: 8g xylitol/200mL milk once/day, 4g xylitol/100mL milk twice/day, 8g sorbitol/200mL milk once/day, 4g sorbitol/100mL milk twice/day, or 8g sucrose/200mL milk once/day. The primary outcome was plaque mutans streptococci (MS) at nine-months. A secondary outcome was tooth decay incidence. We hypothesized children in the xylitol groups would have a greater MS decline and lower tooth decay incidence. Results One-hundred-thirty-five children were included in the intent-to-treat analyses. Children receiving xylitol had a greater reduction in MS than sucrose (P=0.02) but were not different from sorbitol (P=0.07). Tooth decay incidence for xylitol once/day or twice/day was 5.3±3.4 and 4.3±4.0 surfaces, respectively, compared to sorbitol once/day, sorbitol twice/day, or sucrose (4.1±2.8,3.7±4.2, and 3.2±3.4 surfaces, respectively). There were no differences in tooth decay incidence between xylitol and sucrose (Rate Ratio [RR]=1.51;95% confidence interval [CI]=0.88,2.59;P=0.13) or between xylitol and sorbitol (RR=1.28;95% CI=0.90,1.83;P=0.16). Conclusion Xylitol-sweetened milk significantly reduced MS levels compared to sucrose-sweetened milk, but we were unable to detect differences in caries incidence. ISRCTN34705772. PMID:28327266

  18. ECOLOGICAL RISK ASSESSMENT AND THE PRECAUTIONARY PRINCIPLE

    EPA Science Inventory

    The Precautionary Principle, generated during the late 1980s as a unifying principle for regulating discharge of hazardous material into the North Sea, has been broadened to include a shifting of the burden of proof to the proponent of a proposed activity, adoption of a more holi...

  19. Proof-of-principle for SERS imaging of Aspergillus nidulans hyphae using in vivo synthesis of gold nanoparticles.

    PubMed

    Prusinkiewicz, Martin A; Farazkhorasani, Fatemeh; Dynes, James J; Wang, Jian; Gough, Kathleen M; Kaminskyj, Susan G W

    2012-11-07

    High spatial resolution methods to assess the physiology of growing cells should permit analysis of fungal biochemical composition. Whole colony methods cannot capture the details of physiology and organism-environment interaction, in part because the structure, function and composition of fungal hyphae vary within individual cells depending on their distance from the growing apex. Surface Enhanced Raman Scattering (SERS) can provide chemical information on materials that are in close contact with appropriate metal substrates, such as nanopatterned gold surfaces and gold nanoparticles (AuNPs). Since nanoparticles can be generated by living cells, we have created conditions for AuNP formation within and on the surface of Aspergillus nidulans hyphae in order to explore their potential for SERS analysis. AuNP distribution and composition have been assessed by UV-Vis spectroscopy, fluorescence light microscopy, transmission electron microscopy, and scanning transmission X-ray microscopy. AuNPs were often associated with hyphal walls, both in the peripheral cytoplasm and on the outer wall surface. Interpretation of SERS spectra is challenging, and will require validation for the diversity of organic molecules present. Here, we show proof-of-principle that it is possible to generate SERS spectra from nanoparticles grown in situ by living hyphae.

  20. Von Neumann's impossibility proof: Mathematics in the service of rhetorics

    NASA Astrophysics Data System (ADS)

    Dieks, Dennis

    2017-11-01

    According to what has become a standard history of quantum mechanics, in 1932 von Neumann persuaded the physics community that hidden variables are impossible as a matter of principle, after which leading proponents of the Copenhagen interpretation put the situation to good use by arguing that the completeness of quantum mechanics was undeniable. This state of affairs lasted, so the story continues, until Bell in 1966 exposed von Neumann's proof as obviously wrong. The realization that von Neumann's proof was fallacious then rehabilitated hidden variables and made serious foundational research possible again. It is often added in recent accounts that von Neumann's error had been spotted almost immediately by Grete Hermann, but that her discovery was of no effect due to the dominant Copenhagen Zeitgeist. We shall attempt to tell a story that is more historically accurate and less ideologically charged. Most importantly, von Neumann never claimed to have shown the impossibility of hidden variables tout court, but argued that hidden-variable theories must possess a structure that deviates fundamentally from that of quantum mechanics. Both Hermann and Bell appear to have missed this point; moreover, both raised unjustified technical objections to the proof. Von Neumann's argument was basically that hidden-variables schemes must violate the ;quantum principle; that physical quantities are to be represented by operators in a Hilbert space. As a consequence, hidden-variables schemes, though possible in principle, necessarily exhibit a certain kind of contextuality. As we shall illustrate, early reactions to Bohm's theory are in agreement with this account. Leading physicists pointed out that Bohm's theory has the strange feature that pre-existing particle properties do not generally reveal themselves in measurements, in accordance with von Neumann's result. They did not conclude that the ;impossible was done; and that von Neumann had been shown wrong.

  1. Internal short circuit and accelerated rate calorimetry tests of lithium-ion cells: Considerations for methane-air intrinsic safety and explosion proof/flameproof protection methods.

    PubMed

    Dubaniewicz, Thomas H; DuCarme, Joseph P

    2016-09-01

    Researchers with the National Institute for Occupational Safety and Health (NIOSH) studied the potential for lithium-ion cell thermal runaway from an internal short circuit in equipment for use in underground coal mines. In this third phase of the study, researchers compared plastic wedge crush-induced internal short circuit tests of selected lithium-ion cells within methane (CH 4 )-air mixtures with accelerated rate calorimetry tests of similar cells. Plastic wedge crush test results with metal oxide lithium-ion cells extracted from intrinsically safe evaluated equipment were mixed, with one cell model igniting the chamber atmosphere while another cell model did not. The two cells models exhibited different internal short circuit behaviors. A lithium iron phosphate (LiFePO 4 ) cell model was tolerant to crush-induced internal short circuits within CH 4 -air, tested under manufacturer recommended charging conditions. Accelerating rate calorimetry tests with similar cells within a nitrogen purged 353-mL chamber produced ignitions that exceeded explosion proof and flameproof enclosure minimum internal pressure design criteria. Ignition pressures within a 20-L chamber with 6.5% CH 4 -air were relatively low, with much larger head space volume and less adiabatic test conditions. The literature indicates that sizeable lithium thionyl chloride (LiSOCl 2 ) primary (non rechargeable) cell ignitions can be especially violent and toxic. Because ignition of an explosive atmosphere is expected within explosion proof or flameproof enclosures, there is a need to consider the potential for an internal explosive atmosphere ignition in combination with a lithium or lithium-ion battery thermal runaway process, and the resulting effects on the enclosure.

  2. Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study.

    PubMed

    Merege-Filho, Carlos Alberto Abujabra; Otaduy, Maria Concepción Garcia; de Sá-Pinto, Ana Lúcia; de Oliveira, Maira Okada; de Souza Gonçalves, Lívia; Hayashi, Ana Paula Tanaka; Roschel, Hamilton; Pereira, Rosa Maria Rodrigues; Silva, Clovis Artur; Brucki, Sonia Maria Dozzi; da Costa Leite, Claudia; Gualano, Bruno

    2017-02-01

    It has been hypothesized that dietary creatine could influence cognitive performance by increasing brain creatine in developing individuals. This double-blind, randomized, placebo-controlled, proof-of-principle study aimed to investigate the effects of creatine supplementation on cognitive function and brain creatine content in healthy youth. The sample comprised 67 healthy participants aged 10 to 12 years. The participants were given creatine or placebo supplementation for 7 days. At baseline and after the intervention, participants undertook a battery of cognitive tests. In a random subsample of participants, brain creatine content was also assessed in the regions of left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe by proton magnetic resonance spectroscopy (1H-MRS) technique. The scores obtained from verbal learning and executive functions tests did not significantly differ between groups at baseline or after the intervention (all p > 0.05). Creatine content was not significantly different between groups in left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe (all p > 0.05). In conclusion, a 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis.

  3. GPU acceleration of the Locally Selfconsistent Multiple Scattering code for first principles calculation of the ground state and statistical physics of materials

    DOE PAGES

    Eisenbach, Markus; Larkin, Jeff; Lutjens, Justin; ...

    2016-07-12

    The Locally Self-consistent Multiple Scattering (LSMS) code solves the first principles Density Functional theory Kohn–Sham equation for a wide range of materials with a special focus on metals, alloys and metallic nano-structures. It has traditionally exhibited near perfect scalability on massively parallel high performance computer architectures. In this paper, we present our efforts to exploit GPUs to accelerate the LSMS code to enable first principles calculations of O(100,000) atoms and statistical physics sampling of finite temperature properties. We reimplement the scattering matrix calculation for GPUs with a block matrix inversion algorithm that only uses accelerator memory. Finally, using the Craymore » XK7 system Titan at the Oak Ridge Leadership Computing Facility we achieve a sustained performance of 14.5PFlop/s and a speedup of 8.6 compared to the CPU only code.« less

  4. Conservative relativity principle: Logical ground and analysis of relevant experiments

    NASA Astrophysics Data System (ADS)

    Kholmetskii, Alexander; Yarman, Tolga; Missevitch, Oleg

    2014-05-01

    We suggest a new relativity principle, which asserts the impossibility to distinguish the state of rest and the state of motion at the constant velocity of a system, if no work is done to the system in question during its motion. We suggest calling this new rule as "conservative relativity principle" (CRP). In the case of an empty space, CRP is reduced to the Einstein special relativity principle. We also show that CRP is compatible with the general relativity principle. One of important implications of CRP is the dependence of the proper time of a charged particle on the electric potential at its location. In the present paper we consider the relevant experimental facts gathered up to now, where the latter effect can be revealed. We show that in atomic physics the introduction of this effect furnishes a better convergence between theory and experiment than that provided by the standard approach. Finally, we reanalyze the Mössbauer experiments in rotating systems and show that the obtained recently puzzling deviation of the relative energy shift between emission and absorption lines from the relativistic prediction can be explained by the CRP.

  5. Accelerated Aging Experiments for Prognostics of Damage Growth in Composite Materials

    DTIC Science & Technology

    2011-09-01

    possible resource to collect such data is an accelerated aging platform. To that end this paper describes a fatigue cycling experiment with the goal to...possible resource to collect such data is an accelerated aging platform. To that end this paper describes a fatigue cycling experiment with the goal to...suffer from two damage types: matrix micro-cracks and inter- laminar delamination. When subject to fatigue loading matrix micro-cracks develop in the

  6. Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yamamoto, Tokihiro, E-mail: toyamamoto@ucdavis.edu

    Purpose: Radiotherapy (RT) that selectively avoids irradiating highly functional lung regions may reduce pulmonary toxicity, which is substantial in lung cancer RT. Single-energy computed tomography (CT) pulmonary perfusion imaging has several advantages (e.g., higher resolution) over other modalities and has great potential for widespread clinical implementation, particularly in RT. The purpose of this study was to establish proof-of-principle for single-energy CT perfusion imaging. Methods: Single-energy CT perfusion imaging is based on the following: (1) acquisition of end-inspiratory breath-hold CT scans before and after intravenous injection of iodinated contrast agents, (2) deformable image registration (DIR) for spatial mapping of those twomore » CT image data sets, and (3) subtraction of the precontrast image data set from the postcontrast image data set, yielding a map of regional Hounsfield unit (HU) enhancement, a surrogate for regional perfusion. In a protocol approved by the institutional animal care and use committee, the authors acquired CT scans in the prone position for a total of 14 anesthetized canines (seven canines with normal lungs and seven canines with diseased lungs). The elastix algorithm was used for DIR. The accuracy of DIR was evaluated based on the target registration error (TRE) of 50 anatomic pulmonary landmarks per subject for 10 randomly selected subjects as well as on singularities (i.e., regions where the displacement vector field is not bijective). Prior to perfusion computation, HUs of the precontrast end-inspiratory image were corrected for variation in the lung inflation level between the precontrast and postcontrast end-inspiratory CT scans, using a model built from two additional precontrast CT scans at end-expiration and midinspiration. The authors also assessed spatial heterogeneity and gravitationally directed gradients of regional perfusion for normal lung subjects and diseased lung subjects using a two-sample two

  7. Upper limit for the acceleration gradient in the collinear wake field accelerator as a function of the transformer ratio

    DOE PAGES

    Baturin, Stanislav; Zholents, A.

    2017-06-19

    Here, the interrelation between the accelerating gradient and the transformer ratio in the collinear wake field accelerator has been analyzed. It has been shown that the high transformer ratio and the high efficiency of the energy transfer from the drive bunch to the witness bunch can only be achieved at the expense of the accelerating gradient. Rigorous proof is given that in best cases of meticulously shaped charge density distributions in the drive bunch, the maximum accelerating gradient falls proportionally to the gain in the transformer ratio. Conclusions are verified using several representative examples.

  8. Upper limit for the acceleration gradient in the collinear wake field accelerator as a function of the transformer ratio

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baturin, Stanislav; Zholents, A.

    Here, the interrelation between the accelerating gradient and the transformer ratio in the collinear wake field accelerator has been analyzed. It has been shown that the high transformer ratio and the high efficiency of the energy transfer from the drive bunch to the witness bunch can only be achieved at the expense of the accelerating gradient. Rigorous proof is given that in best cases of meticulously shaped charge density distributions in the drive bunch, the maximum accelerating gradient falls proportionally to the gain in the transformer ratio. Conclusions are verified using several representative examples.

  9. Atwood's Machine: Experiments in an Accelerating Frame.

    ERIC Educational Resources Information Center

    Chee, Chia Teck; Hong, Chia Yee

    1999-01-01

    Experiments in an accelerating frame are hard to perform. Illustrates how simple computer software allows sufficiently rapid and accurate measurements to be made on an arrangement of weights and pulleys known as Atwood's machine. (Author/CCM)

  10. The accelerated residency program: the Marshall University family practice 9-year experience.

    PubMed

    Petrany, Stephen M; Crespo, Richard

    2002-10-01

    In 1989, the American Board of Family Practice (ABFP) approved the first of 12 accelerated residency programs in family practice. These experimental programs provide a 1-year experience for select medical students that combines the requirements of the fourth year of medical school with those of the first year of residency, reducing the total training time by 1 year. This paper reports on the achievements and limitations of the Marshall University accelerated residency program over a 9-year period that began in 1992. Several parameters have been monitored since the inception of the accelerated program and provide the basis for comparison of accelerated and traditional residents. These include initial resident characteristics, performance outcomes, and practice choices. A total of 16 students were accepted into the accelerated track from 1992 through 1998. During the same time period, 44 residents entered the traditional residency program. Accelerated resident tended to be older and had more career experience than their traditional counterparts. As a group, the accelerated residents scored an average of 30 points higher on the final in-training exams provided by the ABFP. All residents in both groups remained at Marshall to complete the full residency training experience, and all those who have taken the ABFP certifying exam have passed. Accelerated residents were more likely to practice in West Virginia, consistent with one of the initial goals for the program. In addition, accelerated residents were more likely to be elected chief resident and choose an academic career than those in the traditional group. Both groups opted for small town or rural practice equally. The Marshall University family practice 9-year experience with the accelerated residency track demonstrates that for carefully selected candidates, the program can provide an overall shortened path to board certification and attract students who excel academically and have high leadership potential

  11. Subjective acceleration of time experience in everyday life across adulthood.

    PubMed

    John, Dennis; Lang, Frieder R

    2015-12-01

    Most people believe that time seems to pass more quickly as they age. Building on assumptions of socioemotional selectivity theory, we investigated whether awareness that one's future lifetime is limited is associated with one's experience of time during everyday activities across adulthood in 3 studies. In the first 2 studies (Study 1: N = 608; Study 2: N = 398), participants completed a web-based version of the day reconstruction method. In Study 3 (N = 392) participants took part in a newly developed tomorrow construction method, a web-based experimental method for assessing everyday life plans. Results confirmed that older adults' subjective interpretation of everyday episodes is that these episodes pass more quickly compared with younger adults. The subjective acceleration of time experience in old age was more pronounced during productive activities than during regenerative-consumptive activities. The age differences were partly related to limited time remaining in life. In addition, subjective acceleration of time experience was associated with positive evaluations of everyday activities. Findings suggest that subjective acceleration of time in older adults' daily lives reflects an adaptation to limitations in time remaining in life. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  12. Contrast Gradient-Based Blood Velocimetry With Computed Tomography: Theory, Simulations, and Proof of Principle in a Dynamic Flow Phantom.

    PubMed

    Korporaal, Johannes G; Benz, Matthias R; Schindera, Sebastian T; Flohr, Thomas G; Schmidt, Bernhard

    2016-01-01

    The aim of this study was to introduce a new theoretical framework describing the relationship between the blood velocity, computed tomography (CT) acquisition velocity, and iodine contrast enhancement in CT images, and give a proof of principle of contrast gradient-based blood velocimetry with CT. The time-averaged blood velocity (v(blood)) inside an artery along the axis of rotation (z axis) is described as the mathematical division of a temporal (Hounsfield unit/second) and spatial (Hounsfield unit/centimeter) iodine contrast gradient. From this new theoretical framework, multiple strategies for calculating the time-averaged blood velocity from existing clinical CT scan protocols are derived, and contrast gradient-based blood velocimetry was introduced as a new method that can calculate v(blood) directly from contrast agent gradients and the changes therein. Exemplarily, the behavior of this new method was simulated for image acquisition with an adaptive 4-dimensional spiral mode consisting of repeated spiral acquisitions with alternating scan direction. In a dynamic flow phantom with flow velocities between 5.1 and 21.2 cm/s, the same acquisition mode was used to validate the simulations and give a proof of principle of contrast gradient-based blood velocimetry in a straight cylinder of 2.5 cm diameter, representing the aorta. In general, scanning with the direction of blood flow results in decreased and scanning against the flow in increased temporal contrast agent gradients. Velocity quantification becomes better for low blood and high acquisition speeds because the deviation of the measured contrast agent gradient from the temporal gradient will increase. In the dynamic flow phantom, a modulation of the enhancement curve, and thus alternation of the contrast agent gradients, can be observed for the adaptive 4-dimensional spiral mode and is in agreement with the simulations. The measured flow velocities in the downslopes of the enhancement curves were in good

  13. An examination of the principles of influence on condom use decision making during casual sex encounters.

    PubMed

    Rinaldi-Miles, Anna; Quick, Brian L; LaVoie, Nicole R

    2014-01-01

    Cialdini's (1984) principles of influence were employed to inform the decision-making process with respect to using condoms during casual sex. In the current study, focus groups (n = 9) were conducted to understand the relationship between the six principles of influence (authority, consistency, liking, reciprocity, scarcity, and social proof) and condom use in casual sex relationships. Results revealed that authority, consistency, and social proof were endorsed often as influencing condom use. Gender differences in the endorsement of the principles were also observed. The results speak to how these principles of influence aide the condom decision-making process during these often spontaneous sexual encounters and are discussed with an emphasis on the theoretical and practical implications for using these principles in future health campaigns.

  14. Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial.

    PubMed

    Chi, Donald L; Zegarra, Graciela; Vasquez Huerta, Elsa C; Castillo, Jorge L; Milgrom, Peter; Roberts, Marilyn C; Cabrera-Matta, Ailin R; Merino, Ana P

    2016-09-15

    To evaluate the efficacy of xylitol-sweetened milk as a caries-preventive strategy. In this nine-month prospective proof-of-principle trial, Peruvian schoolchildren were randomized to one of five different milk groups: (1) eight g of xylitol per 200 mL milk once per day; (2) four g of xylitol per 100 mL milk twice per day; (3) eight g of sorbitol per 200 mL milk once per day; (4) four g of sorbitol per 100 mL milk twice per day; or (5) eight g of sucrose per 200 mL milk once per day. The primary outcome was plaque mutans streptococci (MS) at nine months. A secondary outcome was caries incidence. We hypothesized that children in the xylitol groups would have a greater MS decline and lower caries incidence. One hundred fifty-three children were randomized in the intent-to-treat analyses. Children receiving xylitol had a greater decline in MS than children receiving sucrose (P=0.02) but were not different from children receiving sorbitol (P=0.07). Dental caries incidence for xylitol once per day or twice per day was 5.3±3.4 and 4.3±4.0 surfaces, respectively, compared to sorbitol once per day, sorbitol twice per day, or sucrose (4.1±2.8, 3.7±4.2, and 3.2±3.4 surfaces, respectively). There were no differences in caries incidence between xylitol and sucrose (rate ratio [RR] = 1.51; 95 percent confidence interval [CI] = 0.88, 2.59; P=0.13) or between xylitol and sorbitol (RR = 1.28; 95 percent CI = 0.90, 1.83; P=0.16). Xylitol-sweetened milk significantly reduced mutans streptococci levels compared to sucrose-sweetened milk, but differences in caries incidence were not detected.

  15. Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients.

    PubMed

    Hoffmann, Jürgen; Wallwiener, Diethelm

    2009-04-08

    One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. the avoidance of secondary corrective surgery for surgical defects, rather than taking a generic approach. Starting from an existing, simpler empirical scheme based on the complexity of breast surgical procedures, which was used in-house primarily in operative report-writing, a novel classification of ablative and breast-conserving procedures initially needed to be developed and elaborated systematically. To obtain proof of principle, a prospectively planned analysis of patient records for all major breast cancer-related operations performed at our breast centre in 2005 and 2006 was conducted using the new classification. Data were analysed using basic descriptive statistics such as frequency tables. A novel two-type, six-tier classification system comprising 12 main categories, 13 subcategories and 39 sub-subcategories of oncological, oncoplastic and reconstructive breast cancer-related surgery was successfully developed. Our system permitted unequivocal classification, without exception, of all 1225 procedures performed in 1166 breast cancer patients in 2005 and 2006. Breast cancer-related surgical procedures can be generically classified according to their surgical complexity. Analysis of all major procedures performed at our breast centre during the study period provides proof of principle for this novel classification system. We envisage various applications for this classification, including uses in randomised clinical trials, guideline development, specialist surgical training, continuing professional development as well as quality of care and public health research.

  16. Plasma inverse transition acceleration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xie, Ming

    It can be proved fundamentally from the reciprocity theorem with which the electromagnetism is endowed that corresponding to each spontaneous process of radiation by a charged particle there is an inverse process which defines a unique acceleration mechanism, from Cherenkov radiation to inverse Cherenkov acceleration (ICA) [1], from Smith-Purcell radiation to inverse Smith-Purcell acceleration (ISPA) [2], and from undulator radiation to inverse undulator acceleration (IUA) [3]. There is no exception. Yet, for nearly 30 years after each of the aforementioned inverse processes has been clarified for laser acceleration, inverse transition acceleration (ITA), despite speculation [4], has remained the least understood,more » and above all, no practical implementation of ITA has been found, until now. Unlike all its counterparts in which phase synchronism is established one way or the other such that a particle can continuously gain energy from an acceleration wave, the ITA to be discussed here, termed plasma inverse transition acceleration (PITA), operates under fundamentally different principle. As a result, the discovery of PITA has been delayed for decades, waiting for a conceptual breakthrough in accelerator physics: the principle of alternating gradient acceleration [5, 6, 7, 8, 9, 10]. In fact, PITA was invented [7, 8] as one of several realizations of the new principle.« less

  17. Rapid acceleration leads to rapid weakening in earthquake-like laboratory experiments

    NASA Astrophysics Data System (ADS)

    Chang, J. C.; Lockner, D. A.; Reches, Z.

    2012-12-01

    We simulated the slip of a fault-patch during a large earthquake by rapidly loading an experimental, ring-shaped fault with energy stored in a spinning flywheel. The flywheel abruptly delivers a finite amount of energy by spinning the fault-patch that spontaneously dissipates the energy without operator intervention. We conducted 42 experiments on Sierra White granite (SWG) samples, and 24 experiments on Kasota dolomite (KD) samples. Each experiment starts by spinning a 225 kg disk-shaped flywheel to a prescribed angular velocity. We refer to this experiment as an "earthquake-like slip-event" (ELSE). The strength-evolution in ELSE experiments is similar to the strength-evolution proposed for earthquake models and observed in stick-slip experiments. Further, we found that ELSE experiments are similar to earthquakes in at least three ways: (1) slip driven by the release of a finite amount of stored energy; (2) pattern of fault strength evolution; and (3) seismically observed values, such as average slip, peak-velocity and rise-time. By assuming that the measured slip, D, in ELSE experiments is equivalent to the average slip during an earthquake, we found that ELSE experiments (D = 0.003-4.6 m) correspond to earthquakes in moment-magnitude range of Mw = 4-8. In ELSE experiments, the critical-slip-distance, dc, has mean values of 2.7 cm and 1.2 cm for SWG and KD, that are much shorter than the 1-10 m in steady-state classical experiments in rotary shear systems. We attribute these dc values, to ELSE loading in which the fault-patch is abruptly loaded by impact with a spinning flywheel. Under this loading, the friction-velocity relations are strikingly different from those under steady-state loading on the same rock samples with the same shear system (Reches and Lockner, Nature, 2010). We further note that the slip acceleration in ELSE evolves systematically with fault strength and wear-rate, and that the dynamic weakening is restricted to the period of intense

  18. Theoretical and Experimental Studies in Accelerator Physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenzweig, James

    This report describes research supported by the US Dept. of Energy Office of High Energy Physics (OHEP), performed by the UCLA Particle Beam Physics Laboratory (PBPL). The UCLA PBPL has, over the last two decades-plus, played a critical role in the development of advanced accelerators, fundamental beam physics, and new applications enabled by these thrusts, such as new types of accelerator-based light sources. As the PBPL mission is broad it is natural that it has been grown within the context of the accelerator science and technology stewardship of the OHEP. Indeed, steady OHEP support for the program has always beenmore » central to the success of the PBPL; it has provided stability, and above all has set the over-arching themes for our research directions, which have producing over 500 publications (>120 in high level journals). While other agency support has grown notably in recent years, permitting more vigorous pursuit of the program, it is transient by comparison. Beyond permitting program growth in a time of flat OHEP budgets, the influence of other agency missions is found in push to adapt advanced accelerator methods to applications, in light of the success the field has had in proof-of-principle experiments supported first by the DoE OHEP. This three-pronged PBPL program — advanced accelerators, fundamental beam physics and technology, and revolutionary applications — has produced a generation of students that have had a profound affect on the US accelerator physics community. PBPL graduates, numbering 28 in total, form a significant population group in the accelerator community, playing key roles as university faculty, scientific leaders in national labs (two have been named Panofsky Fellows at SLAC), and vigorous proponents of industrial application of accelerators. Indeed, the development of advanced RF, optical and magnet technology at the PBPL has led directly to the spin-off company, RadiaBeam Technologies, now a leading industrial

  19. Micro-Bubble Experiments at the Van de Graaff Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Z. J.; Wardle, Kent E.; Quigley, K. J.

    In order to test and verify the experimental designs at the linear accelerator (LINAC), several micro-scale bubble ("micro-bubble") experiments were conducted with the 3-MeV Van de Graaff (VDG) electron accelerator. The experimental setups included a square quartz tube, sodium bisulfate solution with different concentrations, cooling coils, gas chromatography (GC) system, raster magnets, and two high-resolution cameras that were controlled by a LabVIEW program. Different beam currents were applied in the VDG irradiation. Bubble generation (radiolysis), thermal expansion, thermal convection, and radiation damage were observed in the experiments. Photographs, videos, and gas formation (O 2 + H 2) data were collected.more » The micro-bubble experiments at VDG indicate that the design of the full-scale bubble experiments at the LINAC is reasonable.« less

  20. Study on hydraulic characteristics of mine dust-proof water supply network

    NASA Astrophysics Data System (ADS)

    Deng, Quanlong; Jiang, Zhongan; Han, Shuo; Fu, Enqi

    2018-01-01

    In order to study the hydraulic characteristics of mine dust-proof water supply network and obtain the change rule of water consumption and water pressure, according to the similarity principle and the fluid continuity equation and energy equation, the similarity criterion of mine dust-proof water supply network is deduced, and a similar model of dust-proof water supply network is established based on the prototype of Kailuan Group, the characteristics of hydraulic parameters in water supply network are studied experimentally. The results show that water pressure at each point is a dynamic process, and there is a negative correlation between water pressure and water consumption. With the increase of water consumption, the pressure of water points show a decreasing trend. According to the structure of the pipe network and the location of the water point, the influence degree on the pressure of each point is different.

  1. Burden of Proof--The Controlling Principle in Applying the First and Fourteenth Amendments.

    ERIC Educational Resources Information Center

    Frels, Kelly

    This paper discusses four major Supreme Court decisions that address the issue of which party has the burden of proof in civil rights cases. Two of the 1977 cases involve the application of the First or Fourteenth Amendments, and two are pattern or practice cases brought pursuant to Title VII of the Civil Rights Act of 1964. The controlling issue…

  2. Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies.

    PubMed

    Ahl, Patrick L; Mensch, Christopher; Hu, Binghua; Pixley, Heidi; Zhang, Lan; Dieter, Lance; Russell, Ryann; Smith, William J; Przysiecki, Craig; Kosinski, Mike; Blue, Jeffrey T

    2016-10-01

    Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output based on formulation input factors such as pH, ionic strength, and excipients. Thermal stability predictions, however, are not enough for regulators. Stability claims must be supported by experimental data. The Quality by Design approach of Design of Experiment (DoE) is well suited to describe formulation outputs such as thermal stability in terms of formulation input factors. A DoE approach particularly at elevated temperatures that induce accelerated degradation can provide empirical understanding of how vaccine formulation input factors and interactions affect vaccine stability output performance. This is possible even when clear scientific understanding of particular formulation stability mechanisms are lacking. A DoE approach was used in an accelerated 37(°)C stability study of an aluminum adjuvant Neisseria meningitidis serogroup B vaccine. Formulation stability differences were identified after only 15 days into the study. We believe this study demonstrates the power of combining DoE methodology with accelerated stress stability studies to accelerate and improve vaccine formulation development programs particularly during the preformulation stage. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  3. The Awful Truth About Zero-Gravity: Space Acceleration Measurement System; Orbital Acceleration Research Experiment

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Earth's gravity holds the Shuttle in orbit, as it does satellites and the Moon. The apparent weightlessness experienced by astronauts and experiments on the Shuttle is a balancing act, the result of free-fall, or continuously falling around Earth. An easy way to visualize what is happening is with a thought experiment that Sir Isaac Newton did in 1686. Newton envisioned a mountain extending above Earth's atmosphere so that friction with the air would be eliminated. He imagined a cannon atop the mountain and aimed parallel to the ground. Firing the cannon propels the cannonball forward. At the same time, Earth's gravity pulls the cannonball down to the surface and eventual impact. Newton visualized using enough powder to just balance gravity so the cannonball would circle the Earth. Like the cannonball, objects orbiting Earth are in continuous free-fall, and it appears that gravity has been eliminated. Yet, that appearance is deceiving. Activities aboard the Shuttle generate a range of accelerations that have effects similar to those of gravity. The crew works and exercises. The main data relay antenna quivers 17 times per second to prevent 'stiction,' where parts stick then release with a jerk. Cooling pumps, air fans, and other systems add vibration. And traces of Earth's atmosphere, even 200 miles up, drag on the Shuttle. While imperceptible to us, these vibrations can have a profound impact on the commercial research and scientific experiments aboard the Shuttle. Measuring these forces is necessary so that researchers and scientists can see what may have affected their experiments when analyzing data. On STS-107 this service is provided by the Space Acceleration Measurement System for Free Flyers (SAMS-FF) and the Orbital Acceleration Research Experiment (OARE). Precision data from these two instruments will help scientists analyze data from their experiments and eliminate outside influences from the phenomena they are studying during the mission.

  4. Vibration isolation technology: Sensitivity of selected classes of experiments to residual accelerations

    NASA Technical Reports Server (NTRS)

    Alexander, J. Iwan D.

    1990-01-01

    The solution was sought of a 2-D axisymmetric moving boundary problem for the sensitivity of isothermal and nonisothermal liquid columns and the sensitivity of thermo-capillary flows to buoyancy driven convection caused by residual accelerations. The sensitivity of a variety of space experiments to residual accelerations are examined. In all the cases discussed, the sensitivity is related to the dynamic response of a fluid. In some cases the sensitivity can be defined by the magnitude of the response of the velocity field. This response may involve motion of the fluid associated with internal density gradients, or the motion of a free liquid surface. For fluids with internal density gradients, the type of acceleration to which the experiment is sensitive will depend on whether buoyancy driven convection must be small in comparison to other types of fluid motion (such as thermocapillary flow), or fluid motion must be suppressed or eliminated (such as in diffusion studies, or directional solidification experiments). The effect of the velocity on the composition and temperature field must be considered, particularly in the vicinity of the melt crystal interface. As far as the response to transient disturbances is concerned the sensitivity is determined by both the magnitude and frequency the acceleration and the characteristic momentum and solute diffusion times.

  5. Staging of RF-accelerating Units in a MEMS-based Ion Accelerator

    NASA Astrophysics Data System (ADS)

    Persaud, A.; Seidl, P. A.; Ji, Q.; Feinberg, E.; Waldron, W. L.; Schenkel, T.; Ardanuc, S.; Vinayakumar, K. B.; Lal, A.

    Multiple Electrostatic Quadrupole Array Linear Accelerators (MEQALACs) provide an opportunity to realize compact radio- frequency (RF) accelerator structures that can deliver very high beam currents. MEQALACs have been previously realized with acceleration gap distances and beam aperture sizes of the order of centimeters. Through advances in Micro-Electro-Mechanical Systems (MEMS) fabrication, MEQALACs can now be scaled down to the sub-millimeter regime and batch processed on wafer substrates. In this paper we show first results from using three RF stages in a compact MEMS-based ion accelerator. The results presented show proof-of-concept with accelerator structures formed from printed circuit boards using a 3 × 3 beamlet arrangement and noble gas ions at 10 keV. We present a simple model to describe the measured results. We also discuss some of the scaling behaviour of a compact MEQALAC. The MEMS-based approach enables a low-cost, highly versatile accelerator covering a wide range of currents (10 μA to 100 mA) and beam energies (100 keV to several MeV). Applications include ion-beam analysis, mass spectrometry, materials processing, and at very high beam powers, plasma heating.

  6. Staging of RF-accelerating Units in a MEMS-based Ion Accelerator

    DOE PAGES

    Persaud, A.; Seidl, P. A.; Ji, Q.; ...

    2017-10-26

    Multiple Electrostatic Quadrupole Array Linear Accelerators (MEQALACs) provide an opportunity to realize compact radio- frequency (RF) accelerator structures that can deliver very high beam currents. MEQALACs have been previously realized with acceleration gap distances and beam aperture sizes of the order of centimeters. Through advances in Micro-Electro-Mechanical Systems (MEMS) fabrication, MEQALACs can now be scaled down to the sub-millimeter regime and batch processed on wafer substrates. In this paper we show first results from using three RF stages in a compact MEMS-based ion accelerator. The results presented show proof-of-concept with accelerator structures formed from printed circuit boards using a 3more » × 3 beamlet arrangement and noble gas ions at 10 keV. We present a simple model to describe the measured results. We also discuss some of the scaling behaviour of a compact MEQALAC. The MEMS-based approach enables a low-cost, highly versatile accelerator covering a wide range of currents (10 μA to 100 mA) and beam energies (100 keV to several MeV). Applications include ion-beam analysis, mass spectrometry, materials processing, and at very high beam powers, plasma heating.« less

  7. Staging of RF-accelerating Units in a MEMS-based Ion Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Persaud, A.; Seidl, P. A.; Ji, Q.

    Multiple Electrostatic Quadrupole Array Linear Accelerators (MEQALACs) provide an opportunity to realize compact radio- frequency (RF) accelerator structures that can deliver very high beam currents. MEQALACs have been previously realized with acceleration gap distances and beam aperture sizes of the order of centimeters. Through advances in Micro-Electro-Mechanical Systems (MEMS) fabrication, MEQALACs can now be scaled down to the sub-millimeter regime and batch processed on wafer substrates. In this paper we show first results from using three RF stages in a compact MEMS-based ion accelerator. The results presented show proof-of-concept with accelerator structures formed from printed circuit boards using a 3more » × 3 beamlet arrangement and noble gas ions at 10 keV. We present a simple model to describe the measured results. We also discuss some of the scaling behaviour of a compact MEQALAC. The MEMS-based approach enables a low-cost, highly versatile accelerator covering a wide range of currents (10 μA to 100 mA) and beam energies (100 keV to several MeV). Applications include ion-beam analysis, mass spectrometry, materials processing, and at very high beam powers, plasma heating.« less

  8. A computer-guided bone block harvesting procedure: a proof-of-principle case report and technical notes.

    PubMed

    De Stavola, Luca; Fincato, Andrea; Albiero, Alberto Maria

    2015-01-01

    During autogenous mandibular bone harvesting, there is a risk of damage to anatomical structures, as the surgeon has no three-dimensional control of the osteotomy planes. The aim of this proof-of-principle case report is to describe a procedure for harvesting a mandibular bone block that applies a computer-guided surgery concept. A partially dentate patient who presented with two vertical defects (one in the maxilla and one in the mandible) was selected for an autogenous mandibular bone block graft. The bone block was planned using a computer-aided design process, with ideal bone osteotomy planes defined beforehand to prevent damage to anatomical structures (nerves, dental roots, etc) and to generate a surgical guide, which defined the working directions in three dimensions for the bone-cutting instrument. Bone block dimensions were planned so that both defects could be repaired. The projected bone block was 37.5 mm in length, 10 mm in height, and 5.7 mm in thickness, and it was grafted in two vertical bone augmentations: an 8 × 21-mm mandibular defect and a 6.5 × 18-mm defect in the maxilla. Supraimposition of the preoperative and postoperative computed tomographic images revealed a procedure accuracy of 0.25 mm. This computer-guided bone harvesting technique enables clinicians to obtain sufficient autogenous bone to manage multiple defects safely.

  9. Spectroscopic measurements of plasma emission light for plasma-based acceleration experiments

    NASA Astrophysics Data System (ADS)

    Filippi, F.; Anania, M. P.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Ferrario, M.; Mostacci, A.; Palumbo, L.; Zigler, A.

    2016-09-01

    Advanced particle accelerators are based on the excitation of large amplitude plasma waves driven by either electron or laser beams. Future experiments scheduled at the SPARC_LAB test facility aim to demonstrate the acceleration of high brightness electron beams through the so-called resonant Plasma Wakefield Acceleration scheme in which a train of electron bunches (drivers) resonantly excites wakefields into a preformed hydrogen plasma; the last bunch (witness) injected at the proper accelerating phase gains energy from the wake. The quality of the accelerated beam depends strongly on plasma density and its distribution along the acceleration length. The measurements of plasma density of the order of 1016-1017 cm-3 can be performed with spectroscopic measurements of the plasma-emitted light. The measured density distribution for hydrogen filled capillary discharge with both Balmer alpha and Balmer beta lines and shot-to-shot variation are here reported.

  10. Proof-of-principle demonstration of a virtual flow meter-based transducer for gaseous helium monitoring in particle accelerator cryogenics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arpaia, P.; Technology Department, European Organization for Nuclear Research; Blanco, E.

    2015-07-15

    A transducer based on a virtual flow meter is proposed for monitoring helium distribution and consumption in cryogenic systems for particle accelerators. The virtual flow meter allows technical and economical constraints, preventing installation of physical instruments in all the needed measurement points, to be overcome. Virtual flow meter performance for the alternative models of Samson [ http://www.samson.de (2015)] and Sereg-Schlumberger [ http://www.slb.com/ (2015)] is compared with the standard IEC 60534-2-1 [Industrial-process control valves—Part 2-1: Flow capacity—sizing equations for fluid flow under installed conditions (2011), https://webstore.iec.ch/publication/2461], for a large temperature range, for both gaseous and liquid helium phases, and for differentmore » pressure drops. Then, the calibration function of the transducer is derived. Finally, the experimental validation for the helium gaseous state on the test station for superconducting magnets in the laboratory SM18 [Pirotte et al., AIP Conf. Proc. 1573, 187 (2014)] at CERN is reported.« less

  11. Opportunities and pitfalls in clinical proof-of-concept: principles and examples.

    PubMed

    Chen, Chao

    2018-04-01

    Clinical proof-of-concept trials crucially inform major resource deployment decisions. This paper discusses several mechanisms for enhancing their rigour and efficiency. The importance of careful consideration when using a surrogate endpoint is illustrated; situational effectiveness of run-in patient enrichment is explored; a versatile tool is introduced to ensure a strong pharmacological underpinning; the benefits of dose-titration are revealed by simulation; and the importance of adequately scheduled observations is shown. The general process of model-based trial design and analysis is described and several examples demonstrate the value in historical data, simulation-guided design, model-based analysis and trial adaptation informed by interim analysis. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. 'Living the rural experience-preparation for practice': The future proofing of sustainable rural midwifery practice through midwifery education.

    PubMed

    Kensington, Mary; Rankin, Jean; Gilkison, Andrea; Daellenbach, Rea; Crowther, Susan; Deery, Ruth; Davies, Lorna

    2018-06-05

    Rural practice presents unique challenges and skill requirements for midwives. New Zealand and Scotland face similar challenges in sustaining a rural midwifery workforce. This paper draws from an international multi-centre study exploring rural midwifery to focus on the education needs of student midwives within pre-registration midwifery programmes in order to determine appropriate preparation for rural practice. The mixed-methods study was conducted with 222 midwives working in rural areas in New Zealand (n = 145) and Scotland (n = 77). Midwives' views were gathered through an anonymous online survey and online discussion forums. Descriptive analysis was used for quantitative data and thematic analysis was conducted with qualitative data. 'Future proofing rural midwifery practice' using education was identified as the overarching central theme in ensuring the sustainability of rural midwives, with two associated principle themes emerging (i) 'preparation for rural practice' and (ii) 'living the experience and seeing the reality'. The majority of participants agreed that pre-registration midwifery programmes should include a rural placement for students and rural-specific education with educational input from rural midwives. This study provides insight into how best to prepare midwives for rural practice within pre-registration midwifery education, in order to meet the needs of midwives and families in the rural context. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Wireless Sensors Grouping Proofs for Medical Care and Ambient Assisted-Living Deployment.

    PubMed

    Trček, Denis

    2016-01-02

    Internet of Things (IoT) devices are rapidly penetrating e-health and assisted living domains, and an increasing proportion among them goes on the account of computationally-weak devices, where security and privacy provisioning alone are demanding tasks, not to mention grouping proofs. This paper, therefore, gives an extensive analysis of such proofs and states lessons learnt to avoid possible pitfalls in future designs. It sticks with prudent engineering techniques in this field and deploys in a novel way the so called non-deterministic principle to provide not only grouping proofs, but (among other) also privacy. The developed solution is analyzed by means of a tangible metric and it is shown to be lightweight, and formally for security.

  14. Choosing experiments to accelerate collective discovery

    DOE PAGES

    Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.; ...

    2015-11-24

    Scientists perform a tiny subset of all possible experiments. What characterizes the experiments they choose? What are the consequences of those choices for the pace of scientific discovery? We model scientific knowledge as a network and science as a sequence of experiments designed to gradually uncover it. By analyzing millions of biomedical articles published over 30 y, we find that biomedical scientists pursue conservative research strategies exploring the local neighborhood of central, important molecules. Although such strategies probably serve scientific careers, we show that they slow scientific advance, especially in mature fields, where more risk and less redundant experimentation wouldmore » accelerate discovery of the network. Lastly, we also consider institutional arrangements that could help science pursue these more efficient strategies.« less

  15. The Notion of Proof in the Context of Elementary School Mathematics

    ERIC Educational Resources Information Center

    Stylianides, Andreas J.

    2007-01-01

    Despite increased appreciation of the role of "proof" in students' mathematical experiences across "all" grades, little research has focused on the issue of understanding and characterizing the notion of proof at the elementary school level. This paper takes a step toward addressing this limitation, by examining the characteristics of four major…

  16. The maximum entropy production principle: two basic questions.

    PubMed

    Martyushev, Leonid M

    2010-05-12

    The overwhelming majority of maximum entropy production applications to ecological and environmental systems are based on thermodynamics and statistical physics. Here, we discuss briefly maximum entropy production principle and raises two questions: (i) can this principle be used as the basis for non-equilibrium thermodynamics and statistical mechanics and (ii) is it possible to 'prove' the principle? We adduce one more proof which is most concise today.

  17. Einstein's Elevator in Class: A Self-Construction by Students for the Study of the Equivalence Principle

    NASA Astrophysics Data System (ADS)

    Kapotis, Efstratios; Kalkanis, George

    2016-10-01

    According to the principle of equivalence, it is impossible to distinguish between gravity and inertial forces that a noninertial observer experiences in his own frame of reference. For example, let's consider an elevator in space that is being accelerated in one direction. An observer inside it would feel as if there was gravity force pulling him toward the opposite direction. The same holds for a person in a stationary elevator located in Earth's gravitational field. No experiment enables us to distinguish between the accelerating elevator in space and the motionless elevator near Earth's surface. Strictly speaking, when the gravitational field is non-uniform (like Earth's), the equivalence principle holds only for experiments in elevators that are small enough and that take place over a short enough period of time (Fig. 1). However, performing an experiment in an elevator in space is impractical. On the other hand, it is easy to combine both forces on the same observer, i.e., gravity and a fictitious inertial force due to acceleration. Imagine an observer in an elevator that falls freely within Earth's gravitational field. The observer experiences gravity pulling him down while it might be said that the inertial force due to gravity acceleration g pulls him up. Gravity and inertial force cancel each other, (mis)leading the observer to believe there is no gravitational field. This study outlines our implementation of a self-construction idea that we have found useful in teaching introductory physics students (undergraduate, non-majors).

  18. Generalizing Landauer's principle

    NASA Astrophysics Data System (ADS)

    Maroney, O. J. E.

    2009-03-01

    In a recent paper [Stud. Hist. Philos. Mod. Phys. 36, 355 (2005)] it is argued that to properly understand the thermodynamics of Landauer’s principle it is necessary to extend the concept of logical operations to include indeterministic operations. Here we examine the thermodynamics of such operations in more detail, extending the work of Landauer to include indeterministic operations and to include logical states with variable entropies, temperatures, and mean energies. We derive the most general statement of Landauer’s principle and prove its universality, extending considerably the validity of previous proofs. This confirms conjectures made that all logical operations may, in principle, be performed in a thermodynamically reversible fashion, although logically irreversible operations would require special, practically rather difficult, conditions to do so. We demonstrate a physical process that can perform any computation without work requirements or heat exchange with the environment. Many widespread statements of Landauer’s principle are shown to be special cases of our generalized principle.

  19. Quantification of Hand Motor Symptoms in Parkinson's Disease: A Proof-of-Principle Study Using Inertial and Force Sensors.

    PubMed

    van den Noort, Josien C; Verhagen, Rens; van Dijk, Kees J; Veltink, Peter H; Vos, Michelle C P M; de Bie, Rob M A; Bour, Lo J; Heida, Ciska T

    2017-10-01

    This proof-of-principle study describes the methodology and explores and demonstrates the applicability of a system, existing of miniature inertial sensors on the hand and a separate force sensor, to objectively quantify hand motor symptoms in patients with Parkinson's disease (PD) in a clinical setting (off- and on-medication condition). Four PD patients were measured in off- and on- dopaminergic medication condition. Finger tapping, rapid hand opening/closing, hand pro/supination, tremor during rest, mental task and kinetic task, and wrist rigidity movements were measured with the system (called the PowerGlove). To demonstrate applicability, various outcome parameters of measured hand motor symptoms of the patients in off- vs. on-medication condition are presented. The methodology described and results presented show applicability of the PowerGlove in a clinical research setting, to objectively quantify hand bradykinesia, tremor and rigidity in PD patients, using a single system. The PowerGlove measured a difference in off- vs. on-medication condition in all tasks in the presented patients with most of its outcome parameters. Further study into the validity and reliability of the outcome parameters is required in a larger cohort of patients, to arrive at an optimal set of parameters that can assist in clinical evaluation and decision-making.

  20. A new electrophoretic focusing principle: focusing of nonamphoteric weak ionogenic analytes using inverse electromigration dispersion profiles.

    PubMed

    Gebauer, Petr; Malá, Zdena; Bocek, Petr

    2010-03-01

    This contribution introduces a new separation principle in CE which offers focusing of weak nonamphoteric ionogenic species and their inherent transport to the detector. The prerequisite condition for application of this principle is the existence of an inverse electromigration dispersion profile, i.e. a profile where pH is decreasing toward the anode or cathode for focusing of anionic or cationic weak analytes, respectively. The theory presented defines the principal conditions under which an analyte is focused on a profile of this type. Since electromigration dispersion profiles are migrating ones, the new principle offers inherent transport of focused analytes into the detection cell. The focusing principle described utilizes a mechanism different from both CZE (where separation is based on the difference in mobilities) and IEF (where separation is based on difference in pI), and hence, offers another separation dimension in CE. The new principle and its theory presented here are supplemented by convincing experiments as their proof.

  1. Student Teachers’ Proof Schemes on Proof Tasks Involving Inequality: Deductive or Inductive?

    NASA Astrophysics Data System (ADS)

    Rosyidi, A. H.; Kohar, A. W.

    2018-01-01

    Exploring student teachers’ proof ability is crucial as it is important for improving the quality of their learning process and help their future students learn how to construct a proof. Hence, this study aims at exploring at the proof schemes of student teachers in the beginning of their studies. Data were collected from 130 proofs resulted by 65 Indonesian student teachers on two proof tasks involving algebraic inequality. To analyse, the proofs were classified into the refined proof schemes level proposed by Lee (2016) ranging from inductive, which only provides irrelevant inferences, to deductive proofs, which consider addressing formal representation. Findings present several examples of each of Lee’s level on the student teachers’ proofs spanning from irrelevant inferences, novice use of examples or logical reasoning, strategic use examples for reasoning, deductive inferences with major and minor logical coherence, and deductive proof with informal and formal representation. Besides, it was also found that more than half of the students’ proofs coded as inductive schemes, which does not meet the requirement for doing the proof for the proof tasks examined in this study. This study suggests teacher educators in teacher colleges to reform the curriculum regarding proof learning which can accommodate the improvement of student teachers’ proving ability from inductive to deductive proof as well from informal to formal proof.

  2. Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.

    PubMed

    Osorio, Fernando G; Bárcena, Clea; Soria-Valles, Clara; Ramsay, Andrew J; de Carlos, Félix; Cobo, Juan; Fueyo, Antonio; Freije, José M P; López-Otín, Carlos

    2012-10-15

    Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic mechanisms. However, the precise nature of the molecular cues involved in this process remains incompletely defined. Here we report that the accumulation of prelamin A isoforms at the nuclear lamina triggers an ATM- and NEMO-dependent signaling pathway that leads to NF-κB activation and secretion of high levels of proinflammatory cytokines in two different mouse models of accelerated aging (Zmpste24(-/-) and Lmna(G609G/G609G) mice). Causal involvement of NF-κB in accelerated aging was demonstrated by the fact that both genetic and pharmacological inhibition of NF-κB signaling prevents age-associated features in these animal models, significantly extending their longevity. Our findings provide in vivo proof of principle for the feasibility of pharmacological modulation of the NF-κB pathway to slow down the progression of physiological and pathological aging.

  3. Wireless Sensors Grouping Proofs for Medical Care and Ambient Assisted-Living Deployment

    PubMed Central

    Trček, Denis

    2016-01-01

    Internet of Things (IoT) devices are rapidly penetrating e-health and assisted living domains, and an increasing proportion among them goes on the account of computationally-weak devices, where security and privacy provisioning alone are demanding tasks, not to mention grouping proofs. This paper, therefore, gives an extensive analysis of such proofs and states lessons learnt to avoid possible pitfalls in future designs. It sticks with prudent engineering techniques in this field and deploys in a novel way the so called non-deterministic principle to provide not only grouping proofs, but (among other) also privacy. The developed solution is analyzed by means of a tangible metric and it is shown to be lightweight, and formally for security. PMID:26729131

  4. The precautionary principle is incoherent.

    PubMed

    Peterson, Martin

    2006-06-01

    This article argues that no version of the precautionary principle can be reasonably applied to decisions that may lead to fatal outcomes. In support of this strong claim, a number of desiderata are proposed, which reasonable rules for rational decision making ought to satisfy. Thereafter, two impossibility theorems are proved, showing that no version of the precautionary principle can satisfy the proposed desiderata. These theorems are directly applicable to recent discussions of the precautionary principle in medicine, biotechnology, environmental management, and related fields. The impossibility theorems do not imply, however, that the precautionary principle is of no relevance at all in policy discussions. Even if it is not a reasonable rule for rational decision making, it is possible to interpret the precautionary principle in other ways, e.g., as an argumentative tool or as an epistemic principle favoring a reversed burden of proof.

  5. Combining computation and experiment to accelerate the discovery of new hydrogen storage materials

    NASA Astrophysics Data System (ADS)

    Siegel, Donald

    2009-03-01

    The potential of emerging technologies such as fuel cells (FCs) and photovoltaics for environmentally-benign power generation has sparked renewed interest in the development of novel materials for high density energy storage. For applications in the transportation sector, the demands placed upon energy storage media are especially stringent, as a potential replacement for fossil-fuel-powered internal combustion engines -- namely, the proton exchange membrane FC -- utilizes hydrogen as a fuel. Although hydrogen has about three times the energy density of gasoline by weight, its volumetric energy density (even at 700 bar) is roughly a factor of six smaller. Consequently, the safe and efficient storage of hydrogen has been identified as one of the key materials-based challenges to realizing a transition to FC vehicles. This talk will present an overview of recent efforts at Ford aimed at developing new materials for reversible, solid state hydrogen storage. A tight coupling between first-principles modeling and experiments has greatly accelerated our efforts, and several examples illustrating the benefits of this approach will be presented.

  6. Examination of Secondary School Seventh Graders' Proof Skills and Proof Schemes

    ERIC Educational Resources Information Center

    Sen, Ceylan; Guler, Gursel

    2015-01-01

    The aim of this study is to examine current proof making skills of secondary school seventh graders using proof schemes. Data of the study were collected in two phases. Initially, Proof Schemes Test, which was developed by the researchers, was administrated to 250 seventh grade students from eight secondary schools, which were chosen randomly. The…

  7. Bully Proofing: What One District Learned about Improving School Climate.

    ERIC Educational Resources Information Center

    Berkey, Leonard G.; Keyes, Barbara J.; Longhurst, James E.

    2001-01-01

    Collaborating with school officials, a group of concerned parents implemented a bully-proofing program throughout their school district. After two years, the results are encouraging; it was received with enthusiasm at the elementary level. Further study will be needed to determine how these principles might be applied at the secondary level. (MKA)

  8. Using the automata processor for fast pattern recognition in high energy physics experiments. A proof of concept

    DOE PAGES

    Michael H. L. S. Wang; Cancelo, Gustavo; Green, Christopher; ...

    2016-06-25

    Here, we explore the Micron Automata Processor (AP) as a suitable commodity technology that can address the growing computational needs of pattern recognition in High Energy Physics (HEP) experiments. A toy detector model is developed for which an electron track confirmation trigger based on the Micron AP serves as a test case. Although primarily meant for high speed text-based searches, we demonstrate a proof of concept for the use of the Micron AP in a HEP trigger application.

  9. Using the automata processor for fast pattern recognition in high energy physics experiments. A proof of concept

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michael H. L. S. Wang; Cancelo, Gustavo; Green, Christopher

    Here, we explore the Micron Automata Processor (AP) as a suitable commodity technology that can address the growing computational needs of pattern recognition in High Energy Physics (HEP) experiments. A toy detector model is developed for which an electron track confirmation trigger based on the Micron AP serves as a test case. Although primarily meant for high speed text-based searches, we demonstrate a proof of concept for the use of the Micron AP in a HEP trigger application.

  10. What is Proof of Concept Research and how does it Generate Epistemic and Ethical Categories for Future Scientific Practice?

    PubMed

    Kendig, Catherine Elizabeth

    2016-06-01

    "Proof of concept" is a phrase frequently used in descriptions of research sought in program announcements, in experimental studies, and in the marketing of new technologies. It is often coupled with either a short definition or none at all, its meaning assumed to be fully understood. This is problematic. As a phrase with potential implications for research and technology, its assumed meaning requires some analysis to avoid it becoming a descriptive category that refers to all things scientifically exciting. I provide a short analysis of proof of concept research and offer an example of it within synthetic biology. I suggest that not only are there activities that circumscribe new epistemological categories but there are also associated normative ethical categories or principles linked to the research. I examine these and provide an outline for an alternative ethical account to describe these activities that I refer to as "extended agency ethics". This view is used to explain how the type of research described as proof of concept also provides an attendant proof of principle that is the result of decision-making that extends across practitioners, their tools, techniques, and the problem solving activities of other research groups.

  11. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Obayashi, T.; Kawashima, N.; Kuriki, K.; Nagatomo, M.; Ninomiya, K.; Sasaki, S.; Ushirokawa, A.; Kudo, I.; Ejiri, M.; Roberts, W. T.

    1982-01-01

    Plans for SEPAC, an instrument array to be used on Spacelab 1 to study vehicle charging and neutralization, beam-plasma interaction in space, beam-atmospheric interaction exciting artificial aurora and airglow, and the electromagnetic-field configuration of the magnetosphere, are presented. The hardware, consisting of electron beam accelerator, magnetoplasma arcjet, neutral-gas plume generator, power supply, diagnostic package (photometer, plasma probes, particle analyzers, and plasma-wave package), TV monitor, and control and data-management unit, is described. The individual SEPAC experiments, the typical operational sequence, and the general outline of the SEPAC follow-on mission are discussed. Some of the experiments are to be joint ventures with AEPI (INS 003) and will be monitored by low-light-level TV.

  12. Cs-doped Mo as surface converter for H{sup −}/D{sup −} generation in negative ion sources: First steps and proof of principle

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schiesko, L., E-mail: loic.schiesko@ipp.mpg.de; Hopf, C.; Höschen, T.

    2015-04-08

    In a proof-of-principle study, molybdenum samples were implanted with a very small dose of Cs in order to test the properties of the compound as a surface converter for negative hydrogen ion production. First results on the properties of Cs doped Mo compounds show a reduction of the work function and a stable H{sup −} yield up to four hours in low density hydrogen plasma. The implanted Cs atoms were stable in the Mo lattice over one year for samples stored in vacuum and not exposed to the plasma. The surface H{sup −} generation mechanisms were identified and a comparisonmore » of the negative ion yield with pure Mo showed that the Cs doped Mo sample’s yield was much larger.« less

  13. The LILIA (laser induced light ions acceleration) experiment at LNF

    NASA Astrophysics Data System (ADS)

    Agosteo, S.; Anania, M. P.; Caresana, M.; Cirrone, G. A. P.; De Martinis, C.; Delle Side, D.; Fazzi, A.; Gatti, G.; Giove, D.; Giulietti, D.; Gizzi, L. A.; Labate, L.; Londrillo, P.; Maggiore, M.; Nassisi, V.; Sinigardi, S.; Tramontana, A.; Schillaci, F.; Scuderi, V.; Turchetti, G.; Varoli, V.; Velardi, L.

    2014-07-01

    Laser-matter interaction at relativistic intensities opens up new research fields in the particle acceleration and related secondary sources, with immediate applications in medical diagnostics, biophysics, material science, inertial confinement fusion, up to laboratory astrophysics. In particular laser-driven ion acceleration is very promising for hadron therapy once the ion energy will attain a few hundred MeV. The limited value of the energy up to now obtained for the accelerated ions is the drawback of such innovative technique to the real applications. LILIA (laser induced light ions acceleration) is an experiment now running at LNF (Frascati) with the goal of producing a real proton beam able to be driven for significant distances (50-75 cm) away from the interaction point and which will act as a source for further accelerating structure. In this paper the description of the experimental setup, the preliminary results of solid target irradiation and start to end simulation for a post-accelerated beam up to 60 MeV are given.

  14. Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle.

    PubMed

    Gutman, Haim; Ben-Ami, Eytan; Shapira-Frommer, Roni; Schachter, Jacob

    2012-08-01

    study may be considered a proof-of-principle investigation, enabling long-term remissions by combining induction therapy and surgery.

  15. Proof of Principle of Ocular sparing in dogs with sinonasal tumors treated with intensity-modulated radiation therapy

    PubMed Central

    Lawrence, Jessica A.; Forrest, Lisa J.; Turek, Michelle M.; Miller, Paul E.; Mackie, T. Rockwell; Jaradat, Hazim A.; Vail, David M.; Dubielzig, Richard R.; Chappell, Richard; Mehta, Minesh P.

    2010-01-01

    Intensity modulated radiation therapy (IMRT) allows optimization of radiation dose delivery to complex tumor volumes with rapid dose drop-off to surrounding normal tissues. A prospective study was performed to evaluate the concept of conformal avoidance using IMRT in canine sinonasal cancer. The potential of IMRT to improve clinical outcome with respect to acute and late ocular toxicity was evaluated. Thirty-one dogs with sinonasal cancer were treated definitively with IMRT using helical tomotherapy and/or dynamic multileaf collimator (DMLC) delivery. Ocular toxicity was evaluated prospectively and compared to a comparable group of historical controls treated with conventional two-dimensional radiotherapy (2D-RT) techniques. Treatment plans were devised for each dog using helical tomotherapy and DMLC that achieved the target dose to the planning treatment volume and limited critical normal tissues to the prescribed dose-volume constraints. Overall acute and late toxicities were limited and minor, detectable by an experienced observer. This was in contrast to the profound ocular morbidity observed in the historical control group treated with 2D-RT. Overall median survival for IMRT treated and 2D treated dogs was 420 days and 411 days, respectively. Compared with conventional techniques, IMRT reduced dose delivered to eyes and resulted in bilateral ocular sparing in the dogs reported herein. These data provide proof-of-principle that conformal avoidance radiotherapy can be delivered through high conformity IMRT, resulting in decreased normal tissue toxicity as compared to historical controls treated with 2D-RT. PMID:20973393

  16. Mechanical engineering and design criteria for the Magnetically Insulated Transmission Experiment Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Staller, G.E.; Hamilton, I.D.; Aker, M.F.

    1978-02-01

    A single-unit electron beam accelerator was designed, fabricated, and assembled in Sandia's Technical Area V to conduct magnetically insulated transmission experiments. Results of these experiments will be utilized in the future design of larger, more complex accelerators. This design makes optimum use of existing facilities and equipment. When designing new components, possible future applications were considered as well as compatibility with existing facilities and hardware.

  17. Absolute acceleration measurements on STS-50 from the Orbital Acceleration Research Experiment (OARE)

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1994-01-01

    Orbital Acceleration Research Experiment (OARE) data on Space Transportation System (STS)-50 have been examined in detail during a 2-day time period. Absolute acceleration levels have been derived at the OARE location, the orbiter center-of-gravity, and at the STS-50 spacelab Crystal Growth Facility. During the interval, the tri-axial OARE raw telemetered acceleration measurements have been filtered using a sliding trimmed mean filter in order to remove large acceleration spikes (e.g., thrusters) and reduce the noise. Twelve OARE measured biases in each acceleration channel during the 2-day interval have been analyzed and applied to the filtered data. Similarly, the in situ measured x-axis scale factors in the sensor's most sensitive range were also analyzed and applied to the data. Due to equipment problem(s) on this flight, both y- and z-axis sensitive range scale factors were determined in a separate process using orbiter maneuvers and subsequently applied to the data. All known significant low-frequency corrections at the OARE location (i.e., both vertical and horizontal gravity-gradient, and rotational effects) were removed from the filtered data in order to produce the acceleration components at the orbiter center-of-gravity, which are the aerodynamic signals along each body axis. Results indicate that there is a force being applied to the Orbiter in addition to the aerodynamic forces. The OARE instrument and all known gravitational and electromagnetic forces have been reexamined, but none produces the observed effect. Thus, it is tentatively concluded that the orbiter is creating the environment observed. At least part of this force is thought to be due to the Flash Evaporator System.

  18. Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle

    PubMed Central

    Westhoff, Connie M.; Uy, Jon Michael; Aguad, Maria; Smeland‐Wagman, Robin; Kaufman, Richard M.; Rehm, Heidi L.; Green, Robert C.; Silberstein, Leslie E.

    2015-01-01

    BACKGROUND There are 346 serologically defined red blood cell (RBC) antigens and 33 serologically defined platelet (PLT) antigens, most of which have known genetic changes in 45 RBC or six PLT genes that correlate with antigen expression. Polymorphic sites associated with antigen expression in the primary literature and reference databases are annotated according to nucleotide positions in cDNA. This makes antigen prediction from next‐generation sequencing data challenging, since it uses genomic coordinates. STUDY DESIGN AND METHODS The conventional cDNA reference sequences for all known RBC and PLT genes that correlate with antigen expression were aligned to the human reference genome. The alignments allowed conversion of conventional cDNA nucleotide positions to the corresponding genomic coordinates. RBC and PLT antigen prediction was then performed using the human reference genome and whole genome sequencing (WGS) data with serologic confirmation. RESULTS Some major differences and alignment issues were found when attempting to convert the conventional cDNA to human reference genome sequences for the following genes: ABO, A4GALT, RHD, RHCE, FUT3, ACKR1 (previously DARC), ACHE, FUT2, CR1, GCNT2, and RHAG. However, it was possible to create usable alignments, which facilitated the prediction of all RBC and PLT antigens with a known molecular basis from WGS data. Traditional serologic typing for 18 RBC antigens were in agreement with the WGS‐based antigen predictions, providing proof of principle for this approach. CONCLUSION Detailed mapping of conventional cDNA annotated RBC and PLT alleles can enable accurate prediction of RBC and PLT antigens from whole genomic sequencing data. PMID:26634332

  19. Apparent violation of the principle of equivalence and killing horizons. [for relativity

    NASA Technical Reports Server (NTRS)

    Zimmerman, R. L.; Farhoosh, H.

    1980-01-01

    By means of the principle of equivalence the qualitative behavior of the Schwarzschild horizon about a uniformly accelerating particle was deduced. This result is confirmed for an exact solution of a uniformly accelerating object in the limit of small accelerations. For large accelerations the Schwarzschild horizon appears to violate the qualitative behavior established via the principle of equivalence. When similar arguments are extended to an observable such as the red shift between two observers, there is no departure from the results expected from the principle of equivalence. The resolution of the paradox is brought about by a compensating effect due to the Rindler horizon.

  20. Space Experiments with Particle Accelerators: SEPAC

    NASA Technical Reports Server (NTRS)

    Burch, J. L.; Roberts, W. T.; Taylor, W. W. L.; Kawashima, N.; Marshall, J. A.; Moses, S. L.; Neubert, T.; Mende, S. B.; Choueiri, E. Y.

    1994-01-01

    The Space Experiments with Particle Accelerators (SEPAC), which flew on the Atmospheric Laboratory for Applications and Science (ATLAS) 1 mission, used new techniques to study natural phenomena in the Earth's upper atmosphere, ionosphere and magnetosphere by introducing energetic perturbations into the system from a high power electron beam with known characteristics. Properties of auroras were studied by directing the electron beam into the upper atmosphere while making measurements of optical emissions. Studies were also performed of the critical ionization velocity phenomenon.

  1. Accelerated Learning: Undergraduate Research Experiences at the Texas A&M Cyclotron Institute

    NASA Astrophysics Data System (ADS)

    Yennello, S. J.

    The Texas A&M Cyclotron Institute (TAMU CI) has had an NSF funded Research Experiences for Undergraduates program since 2004. Each summer about a dozen students from across the country join us for the 10-week program. They are each imbedded in one of the research groups of the TAMU CI and given their own research project. While the main focus of their effort is their individual research project, we also have other activities to broaden their experience. For instance, one of those activities has been involvement in a dedicated group experiment. Because not every experimental group will run during those 10 weeks and the fact that some of the students are in theory research groups, a group research experience allows everyone to actually be involved in an experiment using the accelerator. In stark contrast to the REU students' very focused experience during the summer, Texas A&M undergraduates can be involved in research projects at the Cyclotron throughout the year, often for multiple years. This extended exposure enables Texas A&M students to have a learning experience that cannot be duplicated without a local accelerator. The motivation for the REU program was to share this accelerator experience with students who do not have that opportunity at their home institution.

  2. TEACHING PHYSICS: Atwood's machine: experiments in an accelerating frame

    NASA Astrophysics Data System (ADS)

    Teck Chee, Chia; Hong, Chia Yee

    1999-03-01

    Experiments in an accelerating frame are often difficult to perform, but simple computer software allows sufficiently rapid and accurate measurements to be made on an arrangement of weights and pulleys known as Atwood's machine.

  3. High precision test of the equivalence principle

    NASA Astrophysics Data System (ADS)

    Schlamminger, Stephan; Wagner, Todd; Choi, Ki-Young; Gundlach, Jens; Adelberger, Eric

    2007-05-01

    The equivalence principle is the underlying foundation of General Relativity. Many modern quantum theories of gravity predict violations of the equivalence principle. We are using a rotating torsion balance to search for a new equivalence principle violating, long range interaction. A sensitive torsion balance is mounted on a turntable rotating with constant angular velocity. On the torsion pendulum beryllium and titanium test bodies are installed in a composition dipole configuration. A violation of the equivalence principle would yield to a differential acceleration of the two materials towards a source mass. I will present measurements with a differential acceleration sensitivity of 3x10-15;m/s^2. To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.NWS07.B3.5

  4. US NDC Modernization: Service Oriented Architecture Proof of Concept

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hamlet, Benjamin R.; Encarnacao, Andre Villanova; Jackson, Keilan R.

    2014-12-01

    This report is a progress update on the US NDC Modernization Service Oriented Architecture (SOA) study describing results from a proof of concept project completed from May through September 2013. Goals for this proof of concept are 1) gain experience configuring, using, and running an Enterprise Service Bus (ESB), 2) understand the implications of wrapping existing software in standardized interfaces for use as web services, and 3) gather performance metrics for a notional seismic event monitoring pipeline implemented using services with various data access and communication patterns. The proof of concept is a follow on to a previous SOA performancemore » study. Work was performed by four undergraduate summer student interns under the guidance of Sandia staff.« less

  5. The sociomicrobiology of antivirulence drug resistance: a proof of concept.

    PubMed

    Mellbye, Brett; Schuster, Martin

    2011-01-01

    Antivirulence drugs disarm rather than kill pathogens and are thought to alleviate the problem of resistance, although there is no evidence to support this notion. Quorum sensing (QS) often controls cooperative virulence factor production and is therefore an attractive antivirulence target, for which inhibitors (QSI) have been developed. We designed a proof-of-principle experiment to investigate the impact of bacterial social interactions on the evolution of QSI resistance. We cocultured Pseudomonas aeruginosa QS-deficient mutants with small proportions of the QS-proficient wild type, which in the absence of QSI mimic QSI-sensitive and -resistant variants, respectively. We employed two different QS-dependent nutrients that are degraded by extracellular (public) and cell-associated (private) enzymes. QS mutants (QSI-sensitive mimics) behaved as social cheaters that delayed population growth and prevented enrichment of wild-type cooperators (QSI-resistant mimics) only when nutrient acquisition was public, suggesting that QSI resistance would not spread. This highlights the potential for antivirulence strategies that target cooperative behaviors and provides a conceptual framework for future studies.

  6. The LILIA experiment: Energy selection and post-acceleration of laser generated protons

    NASA Astrophysics Data System (ADS)

    Turchetti, Giorgio; Sinigardi, Stefano; Londrillo, Pasquale; Rossi, Francesco; Sumini, Marco; Giove, Dario; De Martinis, Carlo

    2012-12-01

    The LILIA experiment is planned at the SPARCLAB facility of the Frascati INFN laboratories. We have simulated the laser acceleration of protons, the transport and energy selection with collimators and a pulsed solenoid and the post-acceleration with a compact high field linac. For the highest achievable intensity corresponding to a = 30 over 108 protons at 30 MeV with a 3% spread are selected, and at least107 protons are post-accelerated up to 60 MeV. If a 10 Hz repetition rated can be achieved the delivered dose would be suitable for the treatment of small superficial tumors.

  7. Rethinking the Discovery Function of Proof within the Context of Proofs and Refutations

    ERIC Educational Resources Information Center

    Komatsu, Kotaro; Tsujiyama, Yosuke; Sakamaki, Aruta

    2014-01-01

    Proof and proving are important components of school mathematics and have multiple functions in mathematical practice. Among these functions of proof, this paper focuses on the discovery function that refers to invention of a new statement or conjecture by reflecting on or utilizing a constructed proof. Based on two cases in which eighth and ninth…

  8. A guided abstinence experience to illustrate addiction recovery principles.

    PubMed

    Baldwin, Jeffrey N

    2008-08-15

    To develop and implement an elective pharmacy course that included a guided abstinence experience to illustrate addiction recovery principles. A 1-credit elective course to illustrate addiction recovery principles was developed and implemented. The course required students to give up a habit for 6 weeks that was causing them problems, meet weekly to discuss addiction recovery processes, and relate their experiences in a journal. Course grades were determined by class participation, submitted worksheets, and submission of the journal and a paper concerning their role as a pharmacist in dealing with those with addictions and in recovery. Pre- and posttests consisting of addiction case scenarios were used to assess students' application of course material. Graded course elements, pretesting and posttesting, and student course evaluations indicated that course objectives were met. Over the past 15 years, student enrollment has grown from approximately 10% of pharmacy classes to approximately 50% (average 31 students). A guided abstinence experience was an effective tool for teaching pharmacy students the concepts of addiction and recovery.

  9. BrainFrame: a node-level heterogeneous accelerator platform for neuron simulations

    NASA Astrophysics Data System (ADS)

    Smaragdos, Georgios; Chatzikonstantis, Georgios; Kukreja, Rahul; Sidiropoulos, Harry; Rodopoulos, Dimitrios; Sourdis, Ioannis; Al-Ars, Zaid; Kachris, Christoforos; Soudris, Dimitrios; De Zeeuw, Chris I.; Strydis, Christos

    2017-12-01

    Objective. The advent of high-performance computing (HPC) in recent years has led to its increasing use in brain studies through computational models. The scale and complexity of such models are constantly increasing, leading to challenging computational requirements. Even though modern HPC platforms can often deal with such challenges, the vast diversity of the modeling field does not permit for a homogeneous acceleration platform to effectively address the complete array of modeling requirements. Approach. In this paper we propose and build BrainFrame, a heterogeneous acceleration platform that incorporates three distinct acceleration technologies, an Intel Xeon-Phi CPU, a NVidia GP-GPU and a Maxeler Dataflow Engine. The PyNN software framework is also integrated into the platform. As a challenging proof of concept, we analyze the performance of BrainFrame on different experiment instances of a state-of-the-art neuron model, representing the inferior-olivary nucleus using a biophysically-meaningful, extended Hodgkin-Huxley representation. The model instances take into account not only the neuronal-network dimensions but also different network-connectivity densities, which can drastically affect the workload’s performance characteristics. Main results. The combined use of different HPC technologies demonstrates that BrainFrame is better able to cope with the modeling diversity encountered in realistic experiments while at the same time running on significantly lower energy budgets. Our performance analysis clearly shows that the model directly affects performance and all three technologies are required to cope with all the model use cases. Significance. The BrainFrame framework is designed to transparently configure and select the appropriate back-end accelerator technology for use per simulation run. The PyNN integration provides a familiar bridge to the vast number of models already available. Additionally, it gives a clear roadmap for extending the platform

  10. BrainFrame: a node-level heterogeneous accelerator platform for neuron simulations.

    PubMed

    Smaragdos, Georgios; Chatzikonstantis, Georgios; Kukreja, Rahul; Sidiropoulos, Harry; Rodopoulos, Dimitrios; Sourdis, Ioannis; Al-Ars, Zaid; Kachris, Christoforos; Soudris, Dimitrios; De Zeeuw, Chris I; Strydis, Christos

    2017-12-01

    The advent of high-performance computing (HPC) in recent years has led to its increasing use in brain studies through computational models. The scale and complexity of such models are constantly increasing, leading to challenging computational requirements. Even though modern HPC platforms can often deal with such challenges, the vast diversity of the modeling field does not permit for a homogeneous acceleration platform to effectively address the complete array of modeling requirements. In this paper we propose and build BrainFrame, a heterogeneous acceleration platform that incorporates three distinct acceleration technologies, an Intel Xeon-Phi CPU, a NVidia GP-GPU and a Maxeler Dataflow Engine. The PyNN software framework is also integrated into the platform. As a challenging proof of concept, we analyze the performance of BrainFrame on different experiment instances of a state-of-the-art neuron model, representing the inferior-olivary nucleus using a biophysically-meaningful, extended Hodgkin-Huxley representation. The model instances take into account not only the neuronal-network dimensions but also different network-connectivity densities, which can drastically affect the workload's performance characteristics. The combined use of different HPC technologies demonstrates that BrainFrame is better able to cope with the modeling diversity encountered in realistic experiments while at the same time running on significantly lower energy budgets. Our performance analysis clearly shows that the model directly affects performance and all three technologies are required to cope with all the model use cases. The BrainFrame framework is designed to transparently configure and select the appropriate back-end accelerator technology for use per simulation run. The PyNN integration provides a familiar bridge to the vast number of models already available. Additionally, it gives a clear roadmap for extending the platform support beyond the proof of concept, with improved

  11. NOVEL TECHNIQUE OF POWER CONTROL IN MAGNETRON TRANSMITTERS FOR INTENSE ACCELERATORS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kazakevich, G.; Johnson, R.; Neubauer, M.

    A novel concept of a high-power magnetron transmitter allowing dynamic phase and power control at the frequency of locking signal is proposed. The transmitter compensating parasitic phase and amplitude modulations inherent in Superconducting RF (SRF) cavities within closed feedback loops is intended for powering of the intensity-frontier superconducting accelerators. The con- cept uses magnetrons driven by a sufficient resonant (in- jection-locking) signal and fed by the voltage which can be below the threshold of self-excitation. This provides an extended range of power control in a single magnetron at highest efficiency minimizing the cost of RF power unit and the operationmore » cost. Proof-of-principle of the proposed concept demonstrated in pulsed and CW regimes with 2.45 GHz, 1kW magnetrons is discussed here. A conceptual scheme of the high-power transmitter allowing the dynamic wide-band phase and y power controls is presented and discussed.« less

  12. Human experience and product usability: principles to assist the design of user-product interactions.

    PubMed

    Chamorro-Koc, Marianella; Popovic, Vesna; Emmison, Michael

    2009-07-01

    This paper introduces research that investigates how human experience influences people's understandings of product usability. It describes an experiment that employs visual representation of concepts to elicit participants' ideas of a product's use. Results from the experiment lead to the identification of relationships between human experience, knowledge, and context-of-use--relationships that influence designers' and users' concepts of product usability. These relationships are translated into design principles that inform the design activity with respect to the aspects of experience that trigger people's understanding of a product's use. A design tool (ECEDT) is devised to aid designers in the application of these principles. This tool is then trialled in the context of a design task in order to verify applicability of the findings.

  13. Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants.

    PubMed

    Flint, Robert B; Weteringen, Willem van; Voller, Swantje; Poppe, Jarinda A; Koch, Birgit C P; de Groot, Ronald; Tibboel, Dick; Knibbe, Catherijne A J; Reiss, Irwin K M; Simons, Sinno H P; Dino Research Group

    2017-01-01

    Drug effect evaluation is often based on subjective interpretation of a selection of patient data. Continuous analyses of high frequency patient monitor data are a valuable source to measuring drug effects. However, these have not yet been fully explored in clinical care. We aim to evaluate the usefulness and applicability of high frequency physiological data for analyses of pharmacotherapy. As a proof of principle, the effects of doxapram, a respiratory stimulant, on the oxygenation in preterm infants were studied. Second-to-second physiological data were collected from 12 hours before until 36 hours after start of doxapram loading dose plus continuous maintenance dose in seven preterm infants. Besides physiological data, plasma concentrations of doxapram and keto-doxapram were measured. Arterial oxygen saturation (SpO2) increased after the start of doxapram treatment alongside an increase in heart rate. The respiratory rate remained unaffected. The number of saturation dips and the time below a saturation of 80%, as well as the area under the 80%-saturation-time curve (AUC), were significantly lowered after the start of doxapram. The AUC under 90% saturation also significantly improved after start of doxapram. Plasma concentrations of doxapram and keto-doxapram were measured. Using high-frequency monitoring data, we showed the detailed effects over time of pharmacotherapy. We could objectively determine the respiratory condition and the effects of doxapram treatment in preterm infants. This type of analysis might help to develop individualized drug treatments with tailored dose adjustments based on a closed-loop algorithm. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  14. Accelerated approval of oncology products: the food and drug administration experience.

    PubMed

    Johnson, John R; Ning, Yang-Min; Farrell, Ann; Justice, Robert; Keegan, Patricia; Pazdur, Richard

    2011-04-20

    We reviewed the regulatory history of the accelerated approval process and the US Food and Drug Administration (FDA) experience with accelerated approval of oncology products from its initiation in December 11, 1992, to July 1, 2010. The accelerated approval regulations allowed accelerated approval of products to treat serious or life-threatening diseases based on surrogate endpoints that are reasonably likely to predict clinical benefit. Failure to complete postapproval trials to confirm clinical benefit with due diligence could result in removal of the accelerated approval indication from the market. From December 11, 1992, to July 1, 2010, the FDA granted accelerated approval to 35 oncology products for 47 new indications. Clinical benefit was confirmed in postapproval trials for 26 of the 47 new indications, resulting in conversion to regular approval. The median time between accelerated approval and regular approval of oncology products was 3.9 years (range = 0.8-12.6 years) and the mean time was 4.7 years, representing a substantial time savings in terms of earlier availability of drugs to cancer patients. Three new indications did not show clinical benefit when confirmatory postapproval trials were completed and were subsequently removed from the market or had restricted distribution plans implemented. Confirmatory trials were not completed for 14 new indications. The five longest intervals from receipt of accelerated approval to July 1, 2010, without completion of trials to confirm clinical benefit were 10.5, 6.4, 5.5, 5.5, and 4.7 years. The five longest intervals between accelerated approval and successful conversion to regular approval were 12.6, 9.7, 8.1, 7.5, and 7.4 years. Trials to confirm clinical benefit should be part of the drug development plan and should be in progress at the time of an application seeking accelerated approval to prevent an ineffective drug from remaining on the market for an unacceptable time.

  15. Multiple neural signatures of social proof and deviance during the observation of other people's preferences.

    PubMed

    Schnuerch, Robert; Richter, Jasmin; Koppehele-Gossel, Judith; Gibbons, Henning

    2016-06-01

    Detecting one's agreement with or deviation from other people, a key principle of social cognition, relies on neurocognitive mechanisms involved in reward processing, mismatch detection, and attentional orienting. Previous studies have focused on explicit depictions of the (in)congruency of individual and group judgments. Here, we report data from a novel experimental paradigm in which participants first rated a set of images and were later simply confronted with other individuals' ostensible preferences. Participants strongly aligned their judgments in the direction of other people's deviation from their own initial rating, which was neither an effect of regression toward the mean nor of evaluative conditioning (Experiment 1). Most importantly, we provide neurophysiological evidence of the involvement of fundamental cognitive functions related to social comparison (Experiment 2), even though our paradigm did not overly boost this process. Mismatches, as compared to matches, of preferences were associated with an amplitude increase of a broadly distributed N400-like deflection, suggesting that social deviance is represented in the human brain in a similar way as conflicts or breaches of expectation. Also, both early (P2) and late (LPC) signatures of attentional selection were significantly modulated by the social (mis)match of preferences. Our data thus strengthen and valuably extend previous findings on the neurocognitive principles of social proof. © 2016 Society for Psychophysiological Research.

  16. Formation of a dual-stage pinch-accelerator in a Z-pinch (plasma focus) device

    NASA Astrophysics Data System (ADS)

    Behbahani, R. A.; Hirose, A.; Xiao, C.

    2018-01-01

    A novel dense plasma focus configuration with two separate concentric current sheet run-down regions has been demonstrated to produce several consecutive plasma focusing events. In a proof-of-principle experiment on a low-energy plasma focus device, the measured tube voltages and discharge current have been explained by using circuit analyses of the device. Based on the calculated plasma voltages the occurrence of flash-over phase, axial phase, and compression phase has been discussed. The electrical signals along with the calculated plasma voltages suggest the occurrence of several focusing events in the new structure.

  17. NASA's Microgravity Fluid Physics Program: Tolerability to Residual Accelerations

    NASA Technical Reports Server (NTRS)

    Skarda, J. Raymond

    1998-01-01

    An overview of the NASA microgravity fluid physics program is presented. The necessary quality of a reduced-gravity environment in terms of tolerable residual acceleration or g levels is a concern that is inevitably raised for each new microgravity experiment. Methodologies have been reported in the literature that provide guidance in obtaining reasonable estimates of residual acceleration sensitivity for a broad range of fluid physics phenomena. Furthermore, a relatively large and growing database of microgravity experiments that have successfully been performed in terrestrial reduced gravity facilities and orbiting platforms exists. Similarity of experimental conditions and hardware, in some cases, lead to new experiments adopting prior experiments g-requirements. Rationale applied to other experiments can, in principle, be a valuable guide to assist new Principal Investigators, PIs, in determining the residual acceleration tolerability of their flight experiments. The availability of g-requirements rationale from prior (mu)g experiments is discussed. An example of establishing g tolerability requirements is demonstrated, using a current microgravity fluid physics flight experiment. The Fluids and Combustion Facility (FCF) which is currently manifested on the US Laboratory of the International Space Station (ISS) will provide opportunities for fluid physics and combustion experiments throughout the life of the ISS. Although the FCF is not intended to accommodate all fluid physics experiments, it is expected to meet the science requirements of approximately 80% of the new PIs that enter the microgravity fluid physics program. The residual acceleration requirements for the FCF fluid physics experiments are based on a set of fourteen reference fluid physics experiments which are discussed.

  18. Dual-mass vibratory rate gyroscope with suppressed translational acceleration response and quadrature-error correction capability

    NASA Technical Reports Server (NTRS)

    Clark, William A. (Inventor); Juneau, Thor N. (Inventor); Lemkin, Mark A. (Inventor); Roessig, Allen W. (Inventor)

    2001-01-01

    A microfabricated vibratory rate gyroscope to measure rotation includes two proof-masses mounted in a suspension system anchored to a substrate. The suspension has two principal modes of compliance, one of which is driven into oscillation. The driven oscillation combined with rotation of the substrate about an axis perpendicular to the substrate results in Coriolis acceleration along the other mode of compliance, the sense-mode. The sense-mode is designed to respond to Coriolis accelerationwhile suppressing the response to translational acceleration. This is accomplished using one or more rigid levers connecting the two proof-masses. The lever allows the proof-masses to move in opposite directions in response to Coriolis acceleration. The invention includes a means for canceling errors, termed quadrature error, due to imperfections in implementation of the sensor. Quadrature-error cancellation utilizes electrostatic forces to cancel out undesired sense-axis motion in phase with drive-mode position.

  19. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Taylor, William W. L.

    1994-01-01

    The scientific emphasis of this contract has been on the physics of beam ionosphere interactions, in particular, what are the plasma wave levels stimulated by the Space Experiments with Particle Accelerators (SEPAC) electron beam as it is ejected from the Electron Beam Accelerator (EBA) and passes into and through the ionosphere. There were two different phenomena expected. The first was generation of plasma waves by the interaction of the DC component of the beam with the plasma of the ionosphere, by wave particle interactions. The second was the generation of waves at the pulsing frequency of the beam (AC component). This is referred to as using the beam as a virtual antenna, because the beam of electrons is a coherent electrical current confined to move along the earth's magnetic field. As in a physical antenna, a conductor at a radio or TV station, the beam virtual antenna radiates electromagnetic waves at the frequency of the current variations. These two phenomena were investigated during the period of this contract.

  20. Laser all-ceramic crown removal and pulpal temperature--a laboratory proof-of-principle study.

    PubMed

    Rechmann, P; Buu, N C H; Rechmann, B M T; Finzen, F C

    2015-11-01

    The objective of this proof-of-principle laboratory pilot study was to evaluate the temperature increase in the pulp chamber in a worst case scenario during Er:YAG laser debonding of all-ceramic crowns. Twenty extracted molars were prepared to receive all-ceramic IPS E.max CAD full contour crowns. The crowns were bonded to the teeth with Ivoclar Multilink Automix. Times for laser debonding and temperature rise in the pulp chamber using micro-thermocouples were measured. The Er:YAG was used with 560 mJ/pulse. The irradiation was applied at a distance of 5 mm from the crown surface. Additional air-water spray for cooling was utilized. Each all-ceramic crown was successfully laser debonded with an average debonding time of 135 ± 35 s. No crown fractured, and no damage to the underlying dentin was detected. The bonding cement deteriorated, but no carbonization at the dentin/cement interface occurred. The temperature rise in the pulp chamber averaged 5.4° ± 2.2 °C. During 8 out of the 20 crown removals, the temperature rise exceeded 5.5 °C, lasting 5 to 43 s (average 18.8 ± 11.6 s). A temperature rise of 11.5 °C occurred only once, while seven times the temperature rise was limited to 6.8 ± 0.5 °C. Temperature rises above 5.5 °C occurred only when the laser was applied from one side and additional cooling from the side opposite the irradiation. Er:YAG laser energy can successfully be used to efficiently debond all-ceramic crowns from natural teeth. Temperature rises exceeding 5.5 °C only occur when an additional air/water cooling from a dental syringe is inaccurately directed. To avoid possible thermal damage and to allow further heat diffusion, clinically temperature-reduced water might be applied.

  1. Rapid and accurate detection of urinary pathogens by mobile IMS-based electronic nose: a proof-of-principle study.

    PubMed

    Roine, Antti; Saviauk, Taavi; Kumpulainen, Pekka; Karjalainen, Markus; Tuokko, Antti; Aittoniemi, Janne; Vuento, Risto; Lekkala, Jukka; Lehtimäki, Terho; Tammela, Teuvo L; Oksala, Niku K J

    2014-01-01

    Urinary tract infection (UTI) is a common disease with significant morbidity and economic burden, accounting for a significant part of the workload in clinical microbiology laboratories. Current clinical chemisty point-of-care diagnostics rely on imperfect dipstick analysis which only provides indirect and insensitive evidence of urinary bacterial pathogens. An electronic nose (eNose) is a handheld device mimicking mammalian olfaction that potentially offers affordable and rapid analysis of samples without preparation at athmospheric pressure. In this study we demonstrate the applicability of ion mobility spectrometry (IMS) -based eNose to discriminate the most common UTI pathogens from gaseous headspace of culture plates rapidly and without sample preparation. We gathered a total of 101 culture samples containing four most common UTI bacteries: E. coli, S. saprophyticus, E. faecalis, Klebsiella spp and sterile culture plates. The samples were analyzed using ChemPro 100i device, consisting of IMS cell and six semiconductor sensors. Data analysis was conducted by linear discriminant analysis (LDA) and logistic regression (LR). The results were validated by leave-one-out and 5-fold cross validation analysis. In discrimination of sterile and bacterial samples sensitivity of 95% and specificity of 97% were achieved. The bacterial species were identified with sensitivity of 95% and specificity of 96% using eNose as compared to urine bacterial cultures. These findings strongly demonstrate the ability of our eNose to discriminate bacterial cultures and provides a proof of principle to use this method in urinanalysis of UTI.

  2. Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

    PubMed Central

    Justice, Jamie; Miller, Jordan D.; Newman, John C.; Hashmi, Shahrukh K.; Halter, Jeffrey; Austad, Steve N.; Barzilai, Nir

    2016-01-01

    Therapies targeted at fundamental processes of aging may hold great promise for enhancing the health of a wide population by delaying or preventing a range of age-related diseases and conditions—a concept dubbed the “geroscience hypothesis.” Early, proof-of-concept clinical trials will be a key step in the translation of therapies emerging from model organism and preclinical studies into clinical practice. This article summarizes the outcomes of an international meeting partly funded through the NIH R24 Geroscience Network, whose purpose was to generate concepts and frameworks for early, proof-of-concept clinical trials for therapeutic interventions that target fundamental processes of aging. The goals of proof-of-concept trials include generating preliminary signals of efficacy in an aging-related disease or outcome that will reduce the risk of conducting larger trials, contributing data and biological samples to support larger-scale research by strategic networks, and furthering a dialogue with regulatory agencies on appropriate registration indications. We describe three frameworks for proof-of-concept trials that target age-related chronic diseases, geriatric syndromes, or resilience to stressors. We propose strategic infrastructure and shared resources that could accelerate development of therapies that target fundamental aging processes. PMID:27535966

  3. Teaching Proofs and Algorithms in Discrete Mathematics with Online Visual Logic Puzzles

    ERIC Educational Resources Information Center

    Cigas, John; Hsin, Wen-Jung

    2005-01-01

    Visual logic puzzles provide a fertile environment for teaching multiple topics in discrete mathematics. Many puzzles can be solved by the repeated application of a small, finite set of strategies. Explicitly reasoning from a strategy to a new puzzle state illustrates theorems, proofs, and logic principles. These provide valuable, concrete…

  4. Collaboration between a human group and artificial intelligence can improve prediction of multiple sclerosis course: a proof-of-principle study

    PubMed Central

    Ferraldeschi, Michela; Salvetti, Marco; Zaccaria, Andrea; Crisanti, Andrea; Grassi, Francesca

    2017-01-01

    Background: Multiple sclerosis has an extremely variable natural course. In most patients, disease starts with a relapsing-remitting (RR) phase, which proceeds to a secondary progressive (SP) form. The duration of the RR phase is hard to predict, and to date predictions on the rate of disease progression remain suboptimal. This limits the opportunity to tailor therapy on an individual patient's prognosis, in spite of the choice of several therapeutic options. Approaches to improve clinical decisions, such as collective intelligence of human groups and machine learning algorithms are widely investigated. Methods: Medical students and a machine learning algorithm predicted the course of disease on the basis of randomly chosen clinical records of patients that attended at the Multiple Sclerosis service of Sant'Andrea hospital in Rome. Results: A significant improvement of predictive ability was obtained when predictions were combined with a weight that depends on the consistence of human (or algorithm) forecasts on a given clinical record. Conclusions: In this work we present proof-of-principle that human-machine hybrid predictions yield better prognoses than machine learning algorithms or groups of humans alone. To strengthen this preliminary result, we propose a crowdsourcing initiative to collect prognoses by physicians on an expanded set of patients. PMID:29904574

  5. Collaboration between a human group and artificial intelligence can improve prediction of multiple sclerosis course: a proof-of-principle study.

    PubMed

    Tacchella, Andrea; Romano, Silvia; Ferraldeschi, Michela; Salvetti, Marco; Zaccaria, Andrea; Crisanti, Andrea; Grassi, Francesca

    2017-01-01

    Background: Multiple sclerosis has an extremely variable natural course. In most patients, disease starts with a relapsing-remitting (RR) phase, which proceeds to a secondary progressive (SP) form. The duration of the RR phase is hard to predict, and to date predictions on the rate of disease progression remain suboptimal. This limits the opportunity to tailor therapy on an individual patient's prognosis, in spite of the choice of several therapeutic options. Approaches to improve clinical decisions, such as collective intelligence of human groups and machine learning algorithms are widely investigated. Methods: Medical students and a machine learning algorithm predicted the course of disease on the basis of randomly chosen clinical records of patients that attended at the Multiple Sclerosis service of Sant'Andrea hospital in Rome. Results: A significant improvement of predictive ability was obtained when predictions were combined with a weight that depends on the consistence of human (or algorithm) forecasts on a given clinical record. Conclusions: In this work we present proof-of-principle that human-machine hybrid predictions yield better prognoses than machine learning algorithms or groups of humans alone. To strengthen this preliminary result, we propose a crowdsourcing initiative to collect prognoses by physicians on an expanded set of patients.

  6. Proponents of Creationism but not Proponents of Evolution Frame the Origins Debate in Terms of Proof

    NASA Astrophysics Data System (ADS)

    Barnes, Ralph M.; Church, Rebecca A.

    2013-03-01

    In Study 1, 72 internet documents containing creationism, ID (intelligent design), or evolution content were selected for analysis. All instances of proof cognates (the word "proof" and related terms such as "proven", "disproof", etc.) contained within these documents were identified and labeled in terms of the manner in which the terms were used. In Study 2, frequency counts for six terms (proof, evidence, establish, experiment, test, trial) were conducted on a sample of peer-reviewed research articles in the journal Science and the 72 internet documents included in Study 1. Quantitative and qualitative analyses revealed that proponents of creationism were much more likely than proponents of evolution to frame the creationism/evolution issue in terms of proof (ID proponents fell partway between the other two). Proponents of creationism frequently described empirical data favoring their position as proof of their position. Even more frequently, proponents of creationism described evolutionary scientists as being engaged in failed attempts to prove the truth of the evolutionary position. Evolution documents included fewer proof cognates than creationism or ID documents and the few proof cognates found in evolution documents were rarely used to describe the status of the theory of evolution. Qualitative data analysis indicated that proof cognates were often used to indicate certainty. The asymmetry between evolution and creationism documents was limited primarily to proof cognates; there were no major asymmetries for the terms evidence, establish, experiment, test, and trial. The results may reveal differences in the epistemological commitments of the involved parties.

  7. The STEP mission - Satellite test of the equivalence principle

    NASA Technical Reports Server (NTRS)

    Atzei, A.; Swanson, P.; Anselmi, A.

    1992-01-01

    The STEP experiment is a joint ESA/NASA mission candidate for selection as the next medium science project in the ESA scientific program. ESA and NASA have undertaken a joint feasibility study of STEP. The principles of STEP and details of the mission are presented and the mission and spacecraft are described. The primary objective of STEP is to measure differences in the rate of fall of test masses of different compositions to one part in 10 exp 17 of the total gravitational acceleration, a factor of 10 exp 8 improvement in sensitivity over previous experiments. STEP constitutes a comparison of gravitational and inertial mass or a test of the weak equivalence principle (WEP). A test of WEP that is six orders of magnitude more accurate than previous tests will reveal whether the underlying structure of the universe is filled with undiscovered small forces, necessitating a fundamental change in our theories of matter on all scales.

  8. Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

    PubMed Central

    Osorio, Fernando G.; Bárcena, Clea; Soria-Valles, Clara; Ramsay, Andrew J.; de Carlos, Félix; Cobo, Juan; Fueyo, Antonio; Freije, José M.P.; López-Otín, Carlos

    2012-01-01

    Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic mechanisms. However, the precise nature of the molecular cues involved in this process remains incompletely defined. Here we report that the accumulation of prelamin A isoforms at the nuclear lamina triggers an ATM- and NEMO-dependent signaling pathway that leads to NF-κB activation and secretion of high levels of proinflammatory cytokines in two different mouse models of accelerated aging (Zmpste24−/− and LmnaG609G/G609G mice). Causal involvement of NF-κB in accelerated aging was demonstrated by the fact that both genetic and pharmacological inhibition of NF-κB signaling prevents age-associated features in these animal models, significantly extending their longevity. Our findings provide in vivo proof of principle for the feasibility of pharmacological modulation of the NF-κB pathway to slow down the progression of physiological and pathological aging. PMID:23019125

  9. The Equivalence Principle Experiment for Spin-Polarized Bodies

    NASA Astrophysics Data System (ADS)

    Hsieh, Chang-Huain; Jen, Pin-Yun; Ko, Kai-Li; Li, Keh-Yann; Ni, Wei-Tou; Pan, Sheau-Shi; Shih, Yung-Hui; Tyan, Rong-Jung

    We perform an equivalence principle experiment for a magnetically shielded spin-polarized body of Dy6Fe23. We use a single-pan mass comparator to compare the spin-polarized body with an unpolarized group of masses. The equivalence of spin-up and spin-down positions is good to (1.1 ±7.8)×10-9 in earth gravitational field.

  10. The Muon Ionization Cooling Experiment User Software

    NASA Astrophysics Data System (ADS)

    Dobbs, A.; Rajaram, D.; MICE Collaboration

    2017-10-01

    The Muon Ionization Cooling Experiment (MICE) is a proof-of-principle experiment designed to demonstrate muon ionization cooling for the first time. MICE is currently on Step IV of its data taking programme, where transverse emittance reduction will be demonstrated. The MICE Analysis User Software (MAUS) is the reconstruction, simulation and analysis framework for the MICE experiment. MAUS is used for both offline data analysis and fast online data reconstruction and visualization to serve MICE data taking. This paper provides an introduction to MAUS, describing the central Python and C++ based framework, the data structure and and the code management and testing procedures.

  11. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alex Bogacz; Valeri Lebedev

    2001-10-21

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190MeV/c and proceeding to 50GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice design choices. The resultingmore » arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.« less

  12. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Valeri Lebedev; S. Bogacz

    2001-10-25

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3 GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190 MeV/c and proceeding to 50 GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice designmore » choices. The resulting arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.« less

  13. Changes in blood flow and cellular metabolism at a myofascial trigger point with trigger point release (ischemic compression): a proof-of-principle pilot study

    PubMed Central

    Moraska, Albert F.; Hickner, Robert C.; Kohrt, Wendy M.; Brewer, Alan

    2012-01-01

    Objective To demonstrate proof-of-principle measurement for physiological change within an active myofascial trigger point (MTrP) undergoing trigger point release (ischemic compression). Design Interstitial fluid was sampled continuously at a trigger point before and after intervention. Setting A biomedical research clinic at a university hospital. Participants Two subjects from a pain clinic presenting with chronic headache pain. Interventions A single microdialysis catheter was inserted into an active MTrP of the upper trapezius to allow for continuous sampling of interstitial fluid before and after application of trigger point therapy by a massage therapist. Main Outcome Measures Procedural success, pain tolerance, feasibility of intervention during sample collection, determination of physiologically relevant values for local blood flow, as well as glucose and lactate concentrations. Results Both patients tolerated the microdialysis probe insertion into the MTrP and treatment intervention without complication. Glucose and lactate concentrations were measured in the physiological range. Following intervention, a sustained increase in lactate was noted for both subjects. Conclusions Identifying physiological constituents of MTrP’s following intervention is an important step toward understanding pathophysiology and resolution of myofascial pain. The present study forwards that aim by showing proof-of-concept for collection of interstitial fluid from an MTrP before and after intervention can be accomplished using microdialysis, thus providing methodological insight toward treatment mechanism and pain resolution. Of the biomarkers measured in this study, lactate may be the most relevant for detection and treatment of abnormalities in the MTrP. PMID:22975226

  14. Can repetitive transcranial magnetic stimulation increase muscle strength in functional neurological paresis? A proof-of-principle study.

    PubMed

    Broersma, M; Koops, E A; Vroomen, P C; Van der Hoeven, J H; Aleman, A; Leenders, K L; Maurits, N M; van Beilen, M

    2015-05-01

    Therapeutic options are limited in functional neurological paresis disorder. Earlier intervention studies did not control for a placebo effect, hampering assessment of effectivity. A proof-of-principle investigation was conducted into the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS), using a single-blind two-period placebo-controlled cross-over design. Eleven patients received active 15 Hz rTMS over the contralateral motor cortex (hand area), in two periods of 5 days, for 30 min once a day at 80% of resting motor threshold, with a train length of 2 s and an intertrain interval of 4 s. Eight of these eleven patients were also included in the placebo treatment condition. Primary outcome measure was change in muscle strength as measured by dynamometry after treatment. Secondary outcome measure was the subjective change in muscle strength after treatment. In patients who received both treatments, active rTMS induced a significantly larger median increase in objectively measured muscle strength (24%) compared to placebo rTMS (6%; P < 0.04). Subjective ratings showed no difference due to treatment, i.e. patients did not perceive these objectively measured motor improvements (P = 0.40). Our findings suggest that rTMS by itself can potentially improve muscle weakness in functional neurological paresis disorder. Whereas patients' muscle strength increased as measured with dynamometry, patients did not report increased functioning of the affected hand, subjectively. The results may indicate that decreased muscle strength is not the core symptom and that rTMS should be added to behavioral approaches in functional neurological paresis. © 2015 EAN.

  15. Electron acceleration in pulsed-power driven magnetic-reconnection experiments

    NASA Astrophysics Data System (ADS)

    Halliday, Jonathan; Hare, Jack; Lebedev, Sergey; Suttle, Lee; Bland, Simon; Clayson, Thomas; Tubman, Eleanor; Pikuz, Sergei; Shelkovenko, Tanya

    2017-10-01

    We present recent results from pulsed-power driven magnetic reconnection experiments, fielded on the MAGPIE generator (1.2 MA, 250 ns). The setup used in these experiments produces plasma inflows which are intrinsically magnetised; persist for many hydrodynamic time-scales; and are supersonic. Previous work has focussed on characterising the dynamics of bulk plasma flows, using a suite of diagnostics including laser interferometry, (imaging) Faraday rotation, and Thompson scattering. Measurements show the formation of a well defined, long lasting reconnection layer and demonstrate a power balance between the power into and out of the reconnection region. The work presented here focuses on diagnosing non-thermal electron acceleration by the reconnecting electric field. To achieve this, metal foils were placed in the path of accelerated electrons. Atomic transitions in the foil were collisionally exited by the electron beam, producing a characteristic X-Ray spectrum. This X-Ray emission was diagnosed using spherically bent crystal X-Ray spectrometry, filtered X-Ray pinhole imaging, and X-Ray sensitive PIN diodes.

  16. WINCS-BASED WIRELESS ELECTROCHEMICAL MONITORING OF SEROTONIN (5-HT) USING FAST-SCAN CYCLIC VOLTAMMETRY: PROOF OF PRINCIPLE

    PubMed Central

    Griessenauer, Christoph J.; Chang, Su-Youne; Tye, Susannah J.; Kimble, Christopher J.; Bennet, Kevin E.; Garris, Paul A.; Lee, Kendall H.

    2010-01-01

    Object We previously reported the development of a Wireless Instantaneous Neurotransmitter Concentration System (WINCS) for measuring dopamine and suggested that this technology may be useful for evaluating deep brain stimulation (DBS)-related neuromodulatory effects on neurotransmitter systems. WINCS supports fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM) for real-time, spatially resolved neurotransmitter measurements. The FSCV parameters used to establish WINCS dopamine measurements are not suitable for serotonin, a neurotransmitter implicated in depression, because they lead to CFM fouling and a loss of sensitivity. Here, we incorporate into WINCS a previously described N-shaped waveform applied at a high scan rate to establish wireless serotonin monitoring. Methods FSCV optimized for the detection of serotonin consisted of an N-shaped waveform scanned linearly from a resting potential of, in V, +0.2 to +1.0, then to −0.1 and back to +0.2 at a rate of 1000 V/s. Proof of principle tests included flow injection analysis and electrically evoked serotonin release in the dorsal raphe nucleus of rat brain slices. Results Flow cell injection analysis demonstrated that the N waveform applied at a scan rate of 1000 V/s significantly reduced serotonin fouling of the CFM, relative to that observed with FSCV parameters for dopamine. In brain slices, WINCS reliably detected sub-second serotonin release in the dorsal raphe nucleus evoked by local high-frequency stimulation. Conclusion WINCS supported high-fidelity wireless serotonin monitoring by FSCV at a CFM. In the future such measurements of serotonin in large animal models and in humans may help to establish the mechanism of DBS for psychiatric disease. PMID:20415521

  17. Effects of Experiment Location and Orbiter Attitude on the Residual Acceleration On-Board STS-73 (USML-2)

    NASA Technical Reports Server (NTRS)

    Hakimzadeh, Roshanak; McPherson, Kevin M.; Matisak, Brian P.; Wagar, William O.

    1997-01-01

    A knowledge of the quasi-steady acceleration environment on the NASA Space Shuttle Orbiter is of particular importance for materials processing experiments which are limited by slow diffusive processes. The quasi-steady (less than 1 HZ) acceleration environment on STS-73 (USML-2) was measured using the Orbital Acceleration Research Experiment (OARE) accelerometer. One of the facilities flown on USML-2 was the Crystal Growth Furnace (CGF), which was used by several Principal Investigators (PIS) to grow crystals. In this paper the OARE data mapped to the sample melt location within this furnace is presented. The ratio of the axial to radial components of the quasi-steady acceleration at the melt site is presented. Effects of Orbiter attitude on the acceleration data is discussed.

  18. Proof Problems with Diagrams: An Opportunity for Experiencing Proofs and Refutations

    ERIC Educational Resources Information Center

    Komatsu, Kotaro; Tsujiyama, Yosuke; Sakamaki, Aruta; Koike, Norio

    2014-01-01

    It has become gradually accepted that proof and proving are essential at all grades of mathematical learning. Among the various aspects of proof and proving, this study addresses proofs and refutations described by Lakatos, in particular a part of increasing content by deductive guessing, to introduce an authentic process into mathematics…

  19. Elucidation of covariant proofs in general relativity: example of the use of algebraic software in the shear-free conjecture in MAPLE

    NASA Astrophysics Data System (ADS)

    Huf, P. A.; Carminati, J.

    2018-01-01

    In this paper we explore the use of a new algebraic software package in providing independent covariant proof of a conjecture in general relativity. We examine the proof of two sub-cases of the shear-free conjecture σ =0 => ω Θ =0 by Senovilla et al. (Gen. Relativ. Gravit 30:389-411, 1998): case 1: for dust; case 2: for acceleration parallel to vorticity. We use TensorPack, a software package recently released for the Maple environment. In this paper, we briefly summarise the key features of the software and then demonstrate its use by providing and discussing examples of independent proofs of the paper in question. A full set of our completed proofs is available online at http://www.bach2roq.com/science/maths/GR/ShearFreeProofs.html. We are in agreeance with the equations provided in the original paper, noting that the proofs often require many steps. Furthermore, in our proofs we provide fully worked algebraic steps in such a way that the proofs can be examined systematically, and avoiding hand calculation. It is hoped that the elucidated proofs may be of use to other researchers in verifying the algebraic consistency of the expressions in the paper in question, as well as related literature. Furthermore we suggest that the appropriate use of algebraic software in covariant formalism could be useful for developing research and teaching in GR theory.

  20. Solar Heating Proof-of-Concept Experiment for a Public School Building. Report for the Period 15 Jan. 1974 to 15 May 1974. No. ER-7934.

    ERIC Educational Resources Information Center

    AAI Corp., Baltimore, MD.

    In the middle of January 1974, AAI Corporation received a contract to conduct a solar heating proof-of-concept experiment (POCE) for a public school building. On March 1, 1974, the experiment began as Timonium Elementary School, in Maryland, became the first school in the United States to be heated by solar energy. In this brief period, the…

  1. Dynamic compression of water to 700 GPa: single- and double shock experiments on Sandia's Z machine, first principles simulations, and structure of water planets

    NASA Astrophysics Data System (ADS)

    Mattsson, Thomas R.

    2011-11-01

    Significant progress has over the last few years been made in high energy density physics (HEDP) by executing high-precision multi-Mbar experiments and performing first-principles simulations for elements ranging from carbon [1] to xenon [2]. The properties of water under HEDP conditions are of particular importance in planetary science due to the existence of ice-giants like Neptune and Uranus. Modeling the two planets, as well as water-rich exoplanets, requires knowing the equation of state (EOS), the pressure as a function of density and temperature, of water with high accuracy. Although extensive density functional theory (DFT) simulations have been performed for water under planetary conditions [3] experimental validation has been lacking. Accessing thermodynamic states along planetary isentropes in dynamic compression experiments is challenging because the principal Hugoniot follows a significantly different path in the phase diagram. In this talk, we present experimental data for dynamic compression of water up to 700 GPa, including in a regime of the phase-diagram intersected by the Neptune isentrope and water-rich models for the exoplanet GJ436b. The data was obtained on the Z-accelerator at Sandia National Laboratories by performing magnetically accelerated flyer plate impact experiments measuring both the shock and re-shock in the sample. The high accuracy makes it possible for the data to be used for detailed model validation: the results validate first principles based thermodynamics as a reliable foundation for planetary modeling and confirm the fine effect of including nuclear quantum effects on the shock pressure. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. [4pt] [1] M.D. Knudson, D.H. Dolan, and M.P. Desjarlais, SCIENCE

  2. Proof of the Spin Statistics Connection 2: Relativistic Theory

    NASA Astrophysics Data System (ADS)

    Santamato, Enrico; De Martini, Francesco

    2017-12-01

    The traditional standard theory of quantum mechanics is unable to solve the spin-statistics problem, i.e. to justify the utterly important "Pauli Exclusion Principle" but by the adoption of the complex standard relativistic quantum field theory. In a recent paper (Santamato and De Martini in Found Phys 45(7):858-873, 2015) we presented a proof of the spin-statistics problem in the nonrelativistic approximation on the basis of the "Conformal Quantum Geometrodynamics". In the present paper, by the same theory the proof of the spin-statistics theorem is extended to the relativistic domain in the general scenario of curved spacetime. The relativistic approach allows to formulate a manifestly step-by-step Weyl gauge invariant theory and to emphasize some fundamental aspects of group theory in the demonstration. No relativistic quantum field operators are used and the particle exchange properties are drawn from the conservation of the intrinsic helicity of elementary particles. It is therefore this property, not considered in the standard quantum mechanics, which determines the correct spin-statistics connection observed in Nature (Santamato and De Martini in Found Phys 45(7):858-873, 2015). The present proof of the spin-statistics theorem is simpler than the one presented in Santamato and De Martini (Found Phys 45(7):858-873, 2015), because it is based on symmetry group considerations only, without having recourse to frames attached to the particles. Second quantization and anticommuting operators are not necessary.

  3. The principle of relativity, superluminality and EPR experiments. "Riserratevi sotto coverta ..."

    NASA Astrophysics Data System (ADS)

    Cocciaro, B.

    2015-07-01

    The principle of relativity claims the invariance of the results for experiments carried out in inertial reference frames if the system under examination is not in interaction with the outside world. In this paper it is analysed a model suggested by J. S. Bell, and later developed by P. H. Eberhard, D. Bohm and B. Hiley on the basis of which the EPR correlations would be due to superluminal exchanges between the various parts of the entangled system under examination. In the model the existence of a privileged reference frame (PF) for the propagation of superluminal signals is hypothesized so that these superluminal signals may not give rise to causal paradoxes. According to this model, in an EPR experiment, the entangled system interacts with the outer world since the result of the experiment depends on an entity (the reference frame PF) that is not prepared by the experimenter. The existence of this privileged reference frame makes the model non invariant for Lorentz transformations. In this paper, in opposition to what claimed by the authors mentioned above, the perfect compatibility of the model with the theory of relativity is strongly maintained since, as already said, the principle of relativity does not require that the results of experiments carried out on systems interacting with the outside world should be invariant.

  4. Data-oriented scheduling for PROOF

    NASA Astrophysics Data System (ADS)

    Xu, Neng; Guan, Wen; Wu, Sau Lan; Ganis, Gerardo

    2011-12-01

    The Parallel ROOT Facility - PROOF - is a distributed analysis system optimized for I/O intensive analysis tasks of HEP data. With LHC entering the analysis phase, PROOF has become a natural ingredient for computing farms at Tier3 level. These analysis facilities will typically be used by a few tenths of users, and can also be federated into a sort of analysis cloud corresponding to the Virtual Organization of the experiment. Proper scheduling is required to guarantee fair resource usage, to enforce priority policies and to optimize the throughput. In this paper we discuss an advanced priority system that we are developing for PROOF. The system has been designed to automatically adapt to unknown length of the tasks, to take into account the data location and availability (including distribution across geographically separated sites), and the {group, user} default priorities. In this system, every element - user, group, dataset, job slot and storage - gets its priority and those priorities are dynamically linked with each other. In order to tune the interplay between the various components, we have designed and started implementing a simulation application that can model various type and size of PROOF clusters. In this application a monitoring package records all the changes of them so that we can easily understand and tune the performance. We will discuss the status of our simulation and show examples of the results we are expecting from it.

  5. Acceleration of metal-atom diffusion in electric field at metal/insulator interfaces: First-principles study

    NASA Astrophysics Data System (ADS)

    Nagasawa, Riki; Asayama, Yoshihiro; Nakayama, Takashi

    2018-04-01

    Metal-atom diffusion from metal electrodes into SiO2 in electric fields was studied using first-principles calculations. It was shown in the case without electric field that the diffusion barrier of a metal atom is mainly made of the cohesive energy of bulk metal layers, while the shape of the diffusion potential reflects the hybridization of the metal-atom state with metal-induced gap states (MIGSs) and the electron transfer between the metal atom and the electrode. We found that the metal-atom diffusion is markedly accelerated by the applied electric field, such that the diffusion barrier ϕB(E) decreases almost linearly with increasing electric field strength E. By analyzing the physical origins of the metal-atom diffusion, we derived the universal formula to estimate the diffusion barrier in the electric field, which is closely related to MIGSs.

  6. Electromagnetic induction of nanoscale zerovalent iron particles accelerates the degradation of chlorinated dense non-aqueous phase liquid: Proof of concept.

    PubMed

    Phenrat, Tanapon; Kumloet, Itsaraphong

    2016-12-15

    In this study, a novel electromagnetically enhanced treatment concept is proposed for in situ remediation of a source zone of chlorinated dense non-aqueous phase liquid (DNAPL) that is slowly dissolved, causing contaminated groundwater for centuries. Here, we used polystyrene sulfonate (PSS)-modified nanoscale zerovalent iron (NZVI) particles (ferromagnetic) in combination with a low frequency (LF) (150 kHz) AC electromagnetic field (EMF) to accelerate the degradation of the DNAPLs via enhanced dissolution and reductive dechlorination. Trichloroethylene (TCE) and tetrachloroethylene (PCE) were used in a bench-scaled evaluation. The PSS-modified NZVI successfully targeted the DNAPL/water interface, as evidenced by the Pickering emulsion formation. Dechlorination of TCE- and PCE-DNAPL was measured by quantifying the by-product formation (acetylene, ethene, and ethane). Without magnetic induction heating (MIH) by LF EMF, PSS-modified NZVI transformed TCE- and PCE-DNAPL to ethene and ethane at the rate constants of 12.19 × 10 -3 and 1.00 × 10 -3  μmol/h/m 2 , respectively, following pseudo zero-order reactions. However, four MIH cycles of PSS-NZVI increased the temperature up to 87 °C and increased the rate constants of TCE-DNAPL and PCE-DNAPL up to 14.58 and 58.01 times, respectively, in comparison to the dechlorination rate without MIH. Theoretical analysis suggested that the MIH of the PSS-modified NZVI enhanced the dechlorination of TCE- and PCE-DNAPL via the combination of the enhanced thermal dissolution of DNAPL, the effect of increasing the temperature on the rate constant (the Arrhenius equation), and the accelerated NZVI corrosion. Nevertheless, the effect of the Arrhenius equation was dominant. For the first time, this proof-of-concept study reveals the potential for using polyelectrolyte-modified NZVI coupled with LF EMF as a combined remediation technique for increasing the rate and completeness of in situ chlorinated DNAPL source remediation

  7. The growth of language: Universal Grammar, experience, and principles of computation.

    PubMed

    Yang, Charles; Crain, Stephen; Berwick, Robert C; Chomsky, Noam; Bolhuis, Johan J

    2017-10-01

    Human infants develop language remarkably rapidly and without overt instruction. We argue that the distinctive ontogenesis of child language arises from the interplay of three factors: domain-specific principles of language (Universal Grammar), external experience, and properties of non-linguistic domains of cognition including general learning mechanisms and principles of efficient computation. We review developmental evidence that children make use of hierarchically composed structures ('Merge') from the earliest stages and at all levels of linguistic organization. At the same time, longitudinal trajectories of development show sensitivity to the quantity of specific patterns in the input, which suggests the use of probabilistic processes as well as inductive learning mechanisms that are suitable for the psychological constraints on language acquisition. By considering the place of language in human biology and evolution, we propose an approach that integrates principles from Universal Grammar and constraints from other domains of cognition. We outline some initial results of this approach as well as challenges for future research. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Developing the Systems Engineering Experience Accelerator (SEEA) Prototype and Roadmap

    DTIC Science & Technology

    2013-12-31

    information to be automatically presented without comment. 2.2.2 NEW FEATURES AND CAPABILITIES A number of new multiplayer capabilities were...2.4.1 OVERVIEW The EA game engine has two components: the runtime engine and the tools suite. The tools suite includes the Experience Development...the Learner. Figure 6: Experience Accelerator Logical Block Diagram The EARTE is a multiuser architecture for internet gaming . It has light

  9. The Gift of Time: Today's Academic Acceleration Case Study Voices of Experience

    ERIC Educational Resources Information Center

    Scheibel, Susan Riley

    2010-01-01

    The purpose of this qualitative case study was to examine today's academic acceleration from the lived experience and perspectives of two young adults whose education was shortened, thereby allowing them the gift of time. Through personal interviews, parent interviews, and physical artifacts, the researcher gained a complex, holistic understanding…

  10. Non Locality Proofs in Quantum Mechanics Analyzed by Ordinary Mathematical Logic

    NASA Astrophysics Data System (ADS)

    Nisticò, Giuseppe

    2014-10-01

    The so-called non-locality theorems aim to show that Quantum Mechanics is not consistent with the Locality Principle. Their proofs require, besides the standard postulates of Quantum Theory, further conditions, as for instance the Criterion of Reality, which cannot be formulated in the language of Standard Quantum Theory; this difficulty makes the proofs not verifiable according to usual logico-mathematical methods, and therefore it is a source of the controversial debate about the real implications of these theorems. The present work addresses this difficulty for Bell-type and Stapp's arguments of non-locality. We supplement the formalism of Quantum Mechanics with formal statements inferred from the further conditions in the two different cases. Then an analysis of the two arguments is performed according to ordinary mathematical logic.

  11. Experiment to Detect Accelerating Modes in a Photonic Bandgap Fiber

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    England, R.J.; /SLAC; Colby, E.R.

    An experimental effort is currently underway at the E-163 test beamline at Stanford Linear Accelerator Center to use a hollow-core photonic bandgap (PBG) fiber as a high-gradient laser-based accelerating structure for electron bunches. For the initial stage of this experiment, a 50pC, 60 MeV electron beam will be coupled into the fiber core and the excited modes will be detected using a spectrograph to resolve their frequency signatures in the wakefield radiation generated by the beam. They will describe the experimental plan and recent simulation studies of candidate fibers.

  12. Use of a Force Sensor in Archimedes' Principle Experiment, Determination of Buoyant Force and Acceleration Due To Gravity

    NASA Astrophysics Data System (ADS)

    Aurora, Tarlok

    2013-04-01

    In introductory physics, students verify Archimedes' principle by immersing an object in water in a container, with a side-spout to collect the displaced water, resulting in a large uncertainty, due to surface tension. A modified procedure was introduced, in which a plastic bucket is suspended from a force sensor, and an object hangs underneath the bucket. The object is immersed in water in a glass beaker (without any side spout), and the weight loss is measured with a computer-controlled force sensor. Instead of collecting the water displaced by the object, tap water was added to the bucket to compensate for the weight loss, and the Archimedes' principle was verified within less than a percent. With this apparatus, buoyant force was easily studied as a function of volume of displaced water; as well as a function of density of saline solution. By graphing buoyant force as a function of volume (or density of liquid), value of g was obtained from slope. Apparatus and sources of error will be discussed.

  13. Proof-of-principle experiment of measurement-device-independent quantum key distribution with vector vortex beams

    NASA Astrophysics Data System (ADS)

    Dong, Chen; Zhao, Shang-Hong; Li, Wei; Yang, Jian

    2018-03-01

    In this paper, by combining measurement-device-independent quantum key distribution (MDI-QKD) scheme with entangled photon sources, we present a modified MDI-QKD scheme with pairs of vector vortex(VV) beams, which shows a structure of hybrid entangled entanglement corresponding to intrasystem entanglement and intersystem entanglement. The former entanglement, which is entangled between polarization and orbit angular momentum within each VV beam, is adopted to overcome the polarization misalignment associated with random rotations in quantum key distribution. The latter entanglement, which is entangled between the two VV beams, is used to perform entangled-based MDI-QKD protocol with pair of VV beams to inherit the merit of long distance. The numerical simulations show that our modified scheme can tolerate 97dB with practical detectors. Furthermore, our modified protocol only needs to insert q-plates in practical experiment.

  14. A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning.

    PubMed

    Wang, Ching-Fu; Yang, Shih-Hung; Lin, Sheng-Huang; Chen, Po-Chuan; Lo, Yu-Chun; Pan, Han-Chi; Lai, Hsin-Yi; Liao, Lun-De; Lin, Hui-Ching; Chen, Hsu-Yan; Huang, Wei-Chen; Huang, Wun-Jhu; Chen, You-Yin

    Deep brain stimulation (DBS) has been applied as an effective therapy for treating Parkinson's disease or essential tremor. Several open-loop DBS control strategies have been developed for clinical experiments, but they are limited by short battery life and inefficient therapy. Therefore, many closed-loop DBS control systems have been designed to tackle these problems by automatically adjusting the stimulation parameters via feedback from neural signals, which has been reported to reduce the power consumption. However, when the association between the biomarkers of the model and stimulation is unclear, it is difficult to develop an optimal control scheme for other DBS applications, i.e., DBS-enhanced instrumental learning. Furthermore, few studies have investigated the effect of closed-loop DBS control for cognition function, such as instrumental skill learning, and have been implemented in simulation environments. In this paper, we proposed a proof-of-principle design for a closed-loop DBS system, cognitive-enhancing DBS (ceDBS), which enhanced skill learning based on in vivo experimental data. The ceDBS acquired local field potential (LFP) signal from the thalamic central lateral (CL) nuclei of animals through a neural signal processing system. A strong coupling of the theta oscillation (4-7 Hz) and the learning period was found in the water reward-related lever-pressing learning task. Therefore, the theta-band power ratio, which was the averaged theta band to averaged total band (1-55 Hz) power ratio, could be used as a physiological marker for enhancement of instrumental skill learning. The on-line extraction of the theta-band power ratio was implemented on a field-programmable gate array (FPGA). An autoregressive with exogenous inputs (ARX)-based predictor was designed to construct a CL-thalamic DBS model and forecast the future physiological marker according to the past physiological marker and applied DBS. The prediction could further assist the design of

  15. Exploring Logical Reasoning and Mathematical Proof in Grade 6 Elementary School Students

    ERIC Educational Resources Information Center

    Flegas, Konstantinos; Charalampos, Lemonidis

    2013-01-01

    Research and classroom experience reveal that the construction of mathematical proofs is difficult for all students. While many contemporary mathematics curricula recognize the importance of teaching reasoning and proof, in Greece these concepts are introduced at the secondary education level. In this study, we will attempt to investigate a group…

  16. Cancellation of residual spacecraft accelerations for zero-G space physics experiments

    NASA Technical Reports Server (NTRS)

    Stephens, J. B.

    1977-01-01

    The Drop Dynamics Module houses an acoustic positioning system which counteracts the effects of small accelerations of a spacecraft and thus allows long-term study of free-floating materials such as liquid drops. The acoustic positioning system provides an acoustic 'well' in the center of the experiment chamber. Data collection is by cinematographic photography. The module subsystems are discussed.

  17. Rapid acceleration leads to rapid weakening in earthquake-like laboratory experiments

    USGS Publications Warehouse

    Chang, Jefferson C.; Lockner, David A.; Reches, Z.

    2012-01-01

    After nucleation, a large earthquake propagates as an expanding rupture front along a fault. This front activates countless fault patches that slip by consuming energy stored in Earth’s crust. We simulated the slip of a fault patch by rapidly loading an experimental fault with energy stored in a spinning flywheel. The spontaneous evolution of strength, acceleration, and velocity indicates that our experiments are proxies of fault-patch behavior during earthquakes of moment magnitude (Mw) = 4 to 8. We show that seismically determined earthquake parameters (e.g., displacement, velocity, magnitude, or fracture energy) can be used to estimate the intensity of the energy release during an earthquake. Our experiments further indicate that high acceleration imposed by the earthquake’s rupture front quickens dynamic weakening by intense wear of the fault zone.

  18. Bounds on the power of proofs and advice in general physical theories.

    PubMed

    Lee, Ciarán M; Hoban, Matty J

    2016-06-01

    Quantum theory presents us with the tools for computational and communication advantages over classical theory. One approach to uncovering the source of these advantages is to determine how computation and communication power vary as quantum theory is replaced by other operationally defined theories from a broad framework of such theories. Such investigations may reveal some of the key physical features required for powerful computation and communication. In this paper, we investigate how simple physical principles bound the power of two different computational paradigms which combine computation and communication in a non-trivial fashion: computation with advice and interactive proof systems. We show that the existence of non-trivial dynamics in a theory implies a bound on the power of computation with advice. Moreover, we provide an explicit example of a theory with no non-trivial dynamics in which the power of computation with advice is unbounded. Finally, we show that the power of simple interactive proof systems in theories where local measurements suffice for tomography is non-trivially bounded. This result provides a proof that [Formula: see text] is contained in [Formula: see text], which does not make use of any uniquely quantum structure-such as the fact that observables correspond to self-adjoint operators-and thus may be of independent interest.

  19. Temporal profile measurements of relativistic electron bunch based on wakefield generation

    DOE PAGES

    Bettoni, S.; Craievich, P.; Lutman, A. A.; ...

    2016-02-25

    A complete characterization of the time-resolved longitudinal beam phase space is important to optimize the final performances of an accelerator, and in particular this is crucial for Free Electron Laser (FEL) facilities. In this study we propose a novel method to characterize the profile of a relativistic electron bunch by passively streaking the beam using its self-interaction with the transverse wakefield excited by the bunch itself passing off-axis through a dielectric-lined or a corrugated waveguide. Results of a proof-of-principle experiment at the SwissFEL Injector Test Facility are discussed.

  20. High Frequency, High Gradient Dielectric Wakefield Acceleration Experiments at SLAC and BNL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenzweig, James; /UCLA; Travish, Gil

    Given the recent success of >GV/m dielectric wakefield accelerator (DWA) breakdown experiments at SLAC, and follow-on coherent Cerenkov radiation production at the UCLA Neptune, a UCLA-USC-SLAC collaboration is now implementing a new set of experiments that explore various DWA scenarios. These experiments are motivated by the opportunities presented by the approval of FACET facility at SLAC, as well as unique pulse-train wakefield drivers at BNL. The SLAC experiments permit further exploration of the multi-GeV/m envelope in DWAs, and will entail investigations of novel materials (e.g. CVD diamond) and geometries (Bragg cylindrical structures, slab-symmetric DWAs), and have an over-riding goal ofmore » demonstrating >GeV acceleration in {approx}33 cm DWA tubes. In the nearer term before FACET's commissioning, we are planning measurements at the BNL ATF, in which we drive {approx}50-200 MV/m fields with single pulses or pulse trains. These experiments are of high relevance to enhancing linear collider DWA designs, as they will demonstrate potential for efficient operation with pulse trains.« less

  1. Accelerated Simulation of Kinetic Transport Using Variational Principles and Sparsity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Caflisch, Russel

    This project is centered on the development and application of techniques of sparsity and compressed sensing for variational principles, PDEs and physics problems, in particular for kinetic transport. This included derivation of sparse modes for elliptic and parabolic problems coming from variational principles. The research results of this project are on methods for sparsity in differential equations and their applications and on application of sparsity ideas to kinetic transport of plasmas.

  2. Accelerating Innovation Through Coopetition: The Innovation Learning Network Experience.

    PubMed

    McCarthy, Chris; Ford Carleton, Penny; Krumpholz, Elizabeth; Chow, Marilyn P

    Coopetition, the simultaneous pursuit of cooperation and competition, is a growing force in the innovation landscape. For some organizations, the primary mode of innovation continues to be deeply secretive and highly competitive, but for others, a new style of shared challenges, shared purpose, and shared development has become a superior, more efficient way of working to accelerate innovation capabilities and capacity. Over the last 2 decades, the literature base devoted to coopetition has gradually expanded. However, the field is still in its infancy. The majority of coopetition research is qualitative, primarily consisting of case studies. Few studies have addressed the nonprofit sector or service industries such as health care. The authors believe that this article may offer a unique perspective on coopetition in the context of a US-based national health care learning alliance designed to accelerate innovation, the Innovation Learning Network or ILN. The mission of the ILN is to "Share the joy and pain of innovation," accelerating innovation by sharing solutions, teaching techniques, and cultivating friendships. These 3 pillars (sharing, teaching, and cultivating) form the foundation for coopetition within the ILN. Through the lens of coopetition, we examine the experience of the ILN over the last 10 years and provide case examples that illustrate the benefits and challenges of coopetition in accelerating innovation in health care.

  3. Should Proof Be Minimal? Ms T's Evaluation of Secondary School Students' Proofs

    ERIC Educational Resources Information Center

    Tsamir, Pessia; Tirosh, Dina; Dreyfus, Tommy; Barkai, Ruthi; Tabach, Michal

    2009-01-01

    Calls for reform in mathematics education around the world state that proofs should be part of school mathematics at all levels. Turning these calls into a reality falls on teachers' shoulders. This paper focuses on one secondary school teacher's reactions to students' suggested proofs and justifications in elementary number theory. To determine…

  4. Monodisperse granular flows in viscous dispersions in a centrifugal acceleration field

    NASA Astrophysics Data System (ADS)

    Cabrera, Miguel Angel; Wu, Wei

    2016-04-01

    Granular flows are encountered in geophysical flows and innumerable industrial applications with particulate materials. When mixed with a fluid, a complex network of interactions between the particle- and fluid-phase develops, resulting in a compound material with a yet unclear physical behaviour. In the study of granular suspensions mixed with a viscous dispersion, the scaling of the stress-strain characteristics of the fluid phase needs to account for the level of inertia developed in experiments. However, the required model dimensions and amount of material becomes a main limitation for their study. In recent years, centrifuge modelling has been presented as an alternative for the study of particle-fluid flows in a reduced scaled model in an augmented acceleration field. By formulating simple scaling principles proportional to the equivalent acceleration Ng in the model, the resultant flows share many similarities with field events. In this work we study the scaling principles of the fluid phase and its effects on the flow of granular suspensions. We focus on the dense flow of a monodisperse granular suspension mixed with a viscous fluid phase, flowing down an inclined plane and being driven by a centrifugal acceleration field. The scaled model allows the continuous monitoring of the flow heights, velocity fields, basal pressure and mass flow rates at different Ng levels. The experiments successfully identify the effects of scaling the plastic viscosity of the fluid phase, its relation with the deposition of particles over the inclined plane, and allows formulating a discussion on the suitability of simulating particle-fluid flows in a centrifugal acceleration field.

  5. MeV proton acceleration at kHz repetition rate from ultra-intense laser liquid interaction

    NASA Astrophysics Data System (ADS)

    Morrison, John T.; Feister, Scott; Frische, Kyle D.; Austin, Drake R.; Ngirmang, Gregory K.; Murphy, Neil R.; Orban, Chris; Chowdhury, Enam A.; Roquemore, W. M.

    2018-02-01

    Laser acceleration of ions to ≳MeV energies has been achieved on a variety of Petawatt laser systems, raising the prospect of ion beam applications using compact ultra-intense laser technology. However, translation from proof-of-concept laser experiment into real-world application requires MeV-scale ion energies and an appreciable repetition rate (>Hz). We demonstrate, for the first time, proton acceleration up to 2 MeV energies at a kHz repetition rate using a milli-joule-class short-pulse laser system. In these experiments, 5 mJ of ultrashort-pulse laser energy is delivered at an intensity near 5× {10}18 {{W}} {cm}}-2 onto a thin-sheet, liquid-density target. Key to this effort is a flowing liquid ethylene glycol target formed in vacuum with thicknesses down to 400 nm and full recovery at 70 μs, suggesting its potential use at ≫kHz rate. Novel detectors and experimental methods tailored to high-repetition-rate ion acceleration by lasers were essential to this study and are described. In addition, particle-in-cell simulations of the laser-plasma interaction show good agreement with experimental observations.

  6. Proof of concept of an artificial muscle: theoretical model, numerical model, and hardware experiment.

    PubMed

    Haeufle, D F B; Günther, M; Blickhan, R; Schmitt, S

    2011-01-01

    Recently, the hyperbolic Hill-type force-velocity relation was derived from basic physical components. It was shown that a contractile element CE consisting of a mechanical energy source (active element AE), a parallel damper element (PDE), and a serial element (SE) exhibits operating points with hyperbolic force-velocity dependency. In this paper, the contraction dynamics of this CE concept were analyzed in a numerical simulation of quick release experiments against different loads. A hyperbolic force-velocity relation was found. The results correspond to measurements of the contraction dynamics of a technical prototype. Deviations from the theoretical prediction could partly be explained by the low stiffness of the SE, which was modeled analog to the metal spring in the hardware prototype. The numerical model and hardware prototype together, are a proof of this CE concept and can be seen as a well-founded starting point for the development of Hill-type artificial muscles. This opens up new vistas for the technical realization of natural movements with rehabilitation devices. © 2011 IEEE

  7. Linear Proof Mass Actuator

    NASA Technical Reports Server (NTRS)

    Holloway, Sidney E., III

    1994-01-01

    This paper describes the mechanical design, analysis, fabrication, testing, and lessons learned by developing a uniquely designed spaceflight-like actuator. The linear proof mass actuator (LPMA) was designed to attach to both a large space structure and a ground test model without modification. Previous designs lacked the power to perform in a terrestrial environment while other designs failed to produce the desired accelerations or frequency range for spaceflight applications. Thus, the design for a unique actuator was conceived and developed at NASA Langley Research Center. The basic design consists of four large mechanical parts (mass, upper housing, lower housing, and center support) and numerous smaller supporting components including an accelerometer, encoder, and four drive motors. Fabrication personnel were included early in the design phase of the LPMA as part of an integrated manufacturing process to alleviate potential difficulties in machining an already challenging design. Operating testing of the LPMA demonstrated that the actuator is capable of various types of load functions.

  8. Linear Proof Mass Actuator

    NASA Technical Reports Server (NTRS)

    Holloway, S. E., III

    1995-01-01

    This paper describes the mechanical design, analysis, fabrication, testing, and lessons learned by developing a uniquely designed spaceflight-like actuator. The Linear Proof Mass Actuator (LPMA) was designed to attach to both a large space structure and a ground test model without modification. Previous designs lacked the power to perform in a terrestrial environment while other designs failed to produce the desired accelerations or frequency range for spaceflight applications. Thus, the design for a unique actuator was conceived and developed at NASA Langley Research Center. The basic design consists of four large mechanical parts (Mass, Upper Housing, Lower Housing, and Center Support) and numerous smaller supporting components including an accelerometer, encoder, and four drive motors. Fabrication personnel were included early in the design phase of the LPMA as part of an integrated manufacturing process to alleviate potential difficulties in machining an already challenging design. Operational testing of the LPMA demonstrated that the actuator is capable of various types of load functions.

  9. Pulsed power accelerator for material physics experiments

    DOE PAGES

    Reisman, D.  B.; Stoltzfus, B.  S.; Stygar, W.  A.; ...

    2015-09-01

    We have developed the design of Thor: a pulsed power accelerator that delivers a precisely shaped current pulse with a peak value as high as 7 MA to a strip-line load. The peak magnetic pressure achieved within a 1-cm-wide load is as high as 100 GPa. Thor is powered by as many as 288 decoupled and transit-time isolated bricks. Each brick consists of a single switch and two capacitors connected electrically in series. The bricks can be individually triggered to achieve a high degree of current pulse tailoring. Because the accelerator is impedance matched throughout, capacitor energy is delivered tomore » the strip-line load with an efficiency as high as 50%. We used an iterative finite element method (FEM), circuit, and magnetohydrodynamic simulations to develop an optimized accelerator design. When powered by 96 bricks, Thor delivers as much as 4.1 MA to a load, and achieves peak magnetic pressures as high as 65 GPa. When powered by 288 bricks, Thor delivers as much as 6.9 MA to a load, and achieves magnetic pressures as high as 170 GPa. We have developed an algebraic calculational procedure that uses the single brick basis function to determine the brick-triggering sequence necessary to generate a highly tailored current pulse time history for shockless loading of samples. Thor will drive a wide variety of magnetically driven shockless ramp compression, shockless flyer plate, shock-ramp, equation of state, material strength, phase transition, and other advanced material physics experiments.« less

  10. Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brown, Michael R.

    2006-11-16

    Project Title: Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications PI: Michael R. Brown, Swarthmore College The purpose of the project was to provide theoretical and modeling support to the Swarthmore Spheromak Experiment (SSX). Accordingly, the theoretical effort was tightly integrated into the SSX experimental effort. During the grant period, Michael Brown and his experimental collaborators at Swarthmore, with assistance from W. Matthaeus as appropriate, made substantial progress in understanding the physics SSX plasmas.

  11. Study of Solid State Drives performance in PROOF distributed analysis system

    NASA Astrophysics Data System (ADS)

    Panitkin, S. Y.; Ernst, M.; Petkus, R.; Rind, O.; Wenaus, T.

    2010-04-01

    Solid State Drives (SSD) is a promising storage technology for High Energy Physics parallel analysis farms. Its combination of low random access time and relatively high read speed is very well suited for situations where multiple jobs concurrently access data located on the same drive. It also has lower energy consumption and higher vibration tolerance than Hard Disk Drive (HDD) which makes it an attractive choice in many applications raging from personal laptops to large analysis farms. The Parallel ROOT Facility - PROOF is a distributed analysis system which allows to exploit inherent event level parallelism of high energy physics data. PROOF is especially efficient together with distributed local storage systems like Xrootd, when data are distributed over computing nodes. In such an architecture the local disk subsystem I/O performance becomes a critical factor, especially when computing nodes use multi-core CPUs. We will discuss our experience with SSDs in PROOF environment. We will compare performance of HDD with SSD in I/O intensive analysis scenarios. In particular we will discuss PROOF system performance scaling with a number of simultaneously running analysis jobs.

  12. Acceleration Noise Measurements for LISA

    NASA Astrophysics Data System (ADS)

    Schlamminger, Stephan; Gundlach, Jens

    2005-04-01

    The close spacing between the proof mass and the housing in the LISA (Laser Interferometer Space Antenna) spacecraft has been a concern as there may be spurious feeble forces. Such forces may limit the performance of the gravity wave detector at frequencies below 3 mHz and must be studied experimentally. We are performing ultra sensitive torsion balance tests to investigate such effects. Our torsion pendulum and a nearby plate are designed to simulate the LISA proof mass with its adjacent housing surface. We study torque noise on the pendulum as a function of separation between the surfaces. In order to exceed the LISA requirement we are probing the acceleration noise at much closer separations, than those planned for LISA. We have taken data at separations as small as 0.15 mm.

  13. An Expert System For Tuning Particle-Beam Accelerators

    NASA Astrophysics Data System (ADS)

    Lager, Darrel L.; Brand, Hal R.; Maurer, William J.; Searfus, Robert M.; Hernandez, Jose E.

    1989-03-01

    We have developed a proof-of-concept prototype of an expert system for tuning particle beam accelerators. It is designed to function as an intelligent assistant for an operator. In its present form it implements the strategies and reasoning followed by the operator for steering through the beam transport section of the Advanced Test Accelerator at Lawrence Livermore Laboratory's Site 300. The system is implemented in the language LISP using the Artificial Intelligence concepts of frames, daemons, and a representation we developed called a Monitored Decision Script.

  14. A Physical Proof of the Pythagorean Theorem

    ERIC Educational Resources Information Center

    Treeby, David

    2017-01-01

    What proof of the Pythagorean theorem might appeal to a physics teacher? A proof that involved the notion of mass would surely be of interest. While various proofs of the Pythagorean theorem employ the circumcenter and incenter of a right-angled triangle, we are not aware of any proof that uses the triangle's center of mass. This note details one…

  15. Presence of Old Individuals in a Population Accelerates and Optimizes the Process of Selection: in silico Experiments.

    PubMed

    Chistyakov, V A; Denisenko, Y V; Bren, A B

    2018-02-01

    One of the important components of the concept of aging-phenoptosis (programmed aging) is the notion of aging as an accelerator of evolution having the rank of subconcept. For many reasons, the main being the problematic experimental testing of evolutionary hypotheses, verification of the above-mentioned subconcept can be based primarily on analysis of the internal inconsistency of heuristic models and their correspondence to undisputedly observed facts. To illustrate the acceleration mechanism, and most importantly to structure the evolutionary process in communities that include naturally weakened individuals, V. P. Skulachev offered in 2003 a conceptual model that he later called a "fable about hares". Despite its simplicity, this model has undoubted internal logic. The natural trend in the development of conceptual models is their translation into the language of mathematics. The purpose of the present work was to create a variation of the known multi-agent model "predator-prey" that would allow us to "see" how the presence in the prey population of naturally weakened (old) members stimulates the selection of individuals with traits whose adaptive potential is not devaluated with age. The model (http://homebear.ru/PD) was developed on the Java platform, version 6, NetBeans development environment 8.2. Statistical analysis and preparation of illustrative materials were carried out using environment R, version 3.4.1. The results of numerical experiments set using our model correspond in principle to the provisions of the heuristic model of Skulachev and, consequently, confirm the absence in it of logical contradictions.

  16. The Origin of Alcohol Proof

    ERIC Educational Resources Information Center

    Jensen, William B.

    2004-01-01

    The origin of the "proof" system for measuring the ethanol content of alcoholic beverages is presented. The proof system was originally established for purposes of taxing liquors according to their alcohol content and is different in different countries.

  17. Testing general relativity on accelerators

    DOE PAGES

    Kalaydzhyan, Tigran

    2015-09-07

    Within the general theory of relativity, the curvature of spacetime is related to the energy and momentum of the present matter and radiation. One of the more specific predictions of general relativity is the deflection of light and particle trajectories in the gravitational field of massive objects. Bending angles for electromagnetic waves and light in particular were measured with a high precision. However, the effect of gravity on relativistic massive particles was never studied experimentally. Here we propose and analyze experiments devoted to that purpose. We demonstrate a high sensitivity of the laser Compton scattering at high energy accelerators tomore » the effects of gravity. The main observable – maximal energy of the scattered photons – would experience a significant shift in the ambient gravitational field even for otherwise negligible violation of the equivalence principle. In conclusion, we confirm predictions of general relativity for ultrarelativistic electrons of energy of tens of GeV at a current level of resolution and expect our work to be a starting point of further high-precision studies on current and future accelerators, such as PETRA, European XFEL and ILC.« less

  18. An investigation into the effectiveness of smartphone experiments on students’ conceptual knowledge about acceleration

    NASA Astrophysics Data System (ADS)

    Mazzella, Alessandra; Testa, Italo

    2016-09-01

    This study is a first attempt to investigate effectiveness of smartphone-based activities on students’ conceptual understanding of acceleration. 143 secondary school students (15-16 years old) were involved in two types of activities: smartphone- and non-smartphone activities. The latter consisted in data logging and ‘cookbook’ activities. For the sake of comparison, all activities featured the same phenomena, i.e., the motion on an inclined plane and pendulum oscillations. A pre-post design was adopted, using open questionnaires as probes. Results show only weak statistical differences between the smartphone and non-smartphone groups. Students who followed smartphone activities were more able to design an experiment to measure acceleration and to correctly describe acceleration in a free fall motion. However, students of both groups had many difficulties in drawing acceleration vector along the trajectory of the studied motion. Results suggest that smartphone-based activities may be effective substitutes of traditional experimental settings and represent a valuable aid for teachers who want to implement laboratory activities at secondary school level. However, to achieve a deeper conceptual understanding of acceleration, some issues need to be addressed: what is the reference system of the built-in smartphone sensor; relationships between smartphone acceleration graphs and experimental setup; vector representation of the measured acceleration.

  19. Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation after Brain Damage

    ERIC Educational Resources Information Center

    Kleim, Jeffrey A.; Jones, Theresa A.

    2008-01-01

    Purpose: This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain. Method: Neuroscience research using a variety of models of learning, neurological disease, and trauma are reviewed from the perspective of basic neuroscientists but in a manner intended to be useful for the…

  20. Converting an AEG Cyclotron to H- Acceleration and Extraction

    NASA Astrophysics Data System (ADS)

    Ramsey, Fred; Carroll, Lewis; Rathmann, Tom; Huenges, Ernst; Bechtold, Matthias Mentler Volker

    2009-03-01

    Clinical Trials are under way to evaluate agents labeled with the nuclide 225Ac and its decay product 213Bi, in targeted alpha-immuno-therapy [1]. 225Ac can be produced on a medium-energy cyclotron via the nuclear reaction 226Ra(p,n)225Ac. To demonstrate proof-of-principle, a vintage AEG cyclotron, Model E33 [2], with an internal target, had been employed in a pilot production program at the Technical University of Munich (TUM). To enhance production capability and further support the clinical studies, the TUM facility has recently been refurbished and upgraded, adding a new external beam-line, automated target irradiation and transport systems, new laboratories, hot cells, etc. [3]. An improved high-power rotating target has been built and installed [4]. The AEG cyclotron itself has also been modified and upgraded to accelerate and extract H- ions. We have designed, built, and tested a new axial Penning-type ion source which is optimized for the production of H- ions. The ion source has continued to evolve through experiment and experience. Steady improvements in materials and mechanics have led to enhanced source stability, life-time, and H- production. We have also designed and built a precision H- charge-exchange beam-extraction system which is equipped with a vacuum lock. To fit within the tight mechanical constraint imposed by the narrow magnet gap, the system incorporates a novel chain-drive foil holder and foil-changer mechanism. The reconfigured cyclotron system has now been in operation for more than 1 year. Three long-duration target irradiations have been conducted. The most recent bombardment ran 160 continuous hours at a beam on target of ˜80 microamperes for a total yield of ˜70 milli-curies of 225Ac.

  1. Efficient modeling of laser-plasma accelerator staging experiments using INF&RNO

    NASA Astrophysics Data System (ADS)

    Benedetti, C.; Schroeder, C. B.; Geddes, C. G. R.; Esarey, E.; Leemans, W. P.

    2017-03-01

    The computational framework INF&RNO (INtegrated Fluid & paRticle simulatioN cOde) allows for fast and accurate modeling, in 2D cylindrical geometry, of several aspects of laser-plasma accelerator physics. In this paper, we present some of the new features of the code, including the quasistatic Particle-In-Cell (PIC)/fluid modality, and describe using different computational grids and time steps for the laser envelope and the plasma wake. These and other features allow for a speedup of several orders of magnitude compared to standard full 3D PIC simulations while still retaining physical fidelity. INF&RNO is used to support the experimental activity at the BELLA Center, and we will present an example of the application of the code to the laser-plasma accelerator staging experiment.

  2. A TE-mode accelerator

    NASA Astrophysics Data System (ADS)

    Takeuchi, S.; Sakai, K.; Matsumoto, M.; Sugihara, R.

    1987-04-01

    An accelerator is proposed in which a TE-mode wave is used to drive charged particles in contrast to the usual linear accelerators in which longitudinal electric fields or TM-mode waves are supposed to be utilized. The principle of the acceleration is based on the V(p) x B acceleration of a dynamo force acceleration, in which a charged particle trapped in a transverse wave feels a constant electric field (Faraday induction field) and subsequently is accelerated when an appropriate magnetic field is externally applied in the direction perpendicular to the wave propagation. A pair of dielectric plates is used to produce a slow TE mode. The conditions of the particle trapping the stabilization of the particle orbit are discussed.

  3. Using colors to assess pain in toddlers: validation of "the rainbow pain scale"-a proof-of-principle study.

    PubMed

    Mahon, Paula; Holsti, Liisa; Siden, Harold; Strahlendorf, Caron; Turnham, Lucy; Giaschi, Deborah

    2015-01-01

    Self-report, when available, is considered the ideal way to assess the intensity and other aspects of pain in children. However, self-report scales are often too complex cognitively for preschool-aged children (2-4 years). The Rainbow Pain Scale (RPS) was developed to provide individualized self-reported pain ratings for preschool-aged children. The psychometric properties of this scale have yet to be evaluated. To ensure validity, our first step was to compare RPS scores to a well-validated scale in older children who were able to self-report their pain. The purpose of this study was to assess the concurrent validity of the RPS in children aged 5 to 10 years as proof of principle. We compared ratings of 49 children's pain using the RPS with those on the Faces Pain Scale-Revised (FPS-R). Participants suffering from pain related to cancer and cancer treatment were recruited to complete both scales at 3 time points, during both inpatient and outpatient clinic visits. Pearson's r and Cohen's κ were used to evaluate the level of association between the scales. The association between RPS and the FPS-R was greater than .7 at all 3 visits; r = .96 between the scales at the first clinic visit, .97 at the second visit, and .93 at the third visit. Cohen's κ between scales was 1.0 at the first clinic visit, .95 at the second visit, and .87 at the third visit. The RPS shows excellent concurrent validity with the FPS-R in school-aged children. The next step will be to examine the psychometric properties of the RPS in preschool-aged children. © 2014 by Association of Pediatric Hematology/Oncology Nurses.

  4. Proof test methodology for composites

    NASA Technical Reports Server (NTRS)

    Wu, Edward M.; Bell, David K.

    1992-01-01

    The special requirements for proof test of composites are identified based on the underlying failure process of composites. Two proof test methods are developed to eliminate the inevitable weak fiber sites without also causing flaw clustering which weakens the post-proof-test composite. Significant reliability enhancement by these proof test methods has been experimentally demonstrated for composite strength and composite life in tension. This basic proof test methodology is relevant to the certification and acceptance of critical composite structures. It can also be applied to the manufacturing process development to achieve zero-reject for very large composite structures.

  5. The Wording of a Proof: Hardy's Second "Elegant" Proof--The Pythagorean School's Irrationality of Square Root of 2

    ERIC Educational Resources Information Center

    Padula, Janice

    2006-01-01

    One of the most interesting and important proofs in the history of mathematics is the Pythagorean school's proof of the "irrationality" of the square root of 2. After a brief look at G. H. Hardy (1941) thoughts regarding it, two versions of the classic Pythagorean proof are examined and discussed in this article, one written by an American…

  6. Inner experience in the scanner: can high fidelity apprehensions of inner experience be integrated with fMRI?

    PubMed Central

    Kühn, Simone; Fernyhough, Charles; Alderson-Day, Benjamin; Hurlburt, Russell T.

    2014-01-01

    To provide full accounts of human experience and behavior, research in cognitive neuroscience must be linked to inner experience, but introspective reports of inner experience have often been found to be unreliable. The present case study aimed at providing proof of principle that introspection using one method, descriptive experience sampling (DES), can be reliably integrated with fMRI. A participant was trained in the DES method, followed by nine sessions of sampling within an MRI scanner. During moments where the DES interview revealed ongoing inner speaking, fMRI data reliably showed activation in classic speech processing areas including left inferior frontal gyrus. Further, the fMRI data validated the participant’s DES observations of the experiential distinction between inner speaking and innerly hearing her own voice. These results highlight the precision and validity of the DES method as a technique of exploring inner experience and the utility of combining such methods with fMRI. PMID:25538649

  7. MABE multibeam accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hasti, D.E.; Ramirez, J.J.; Coleman, P.D.

    1985-01-01

    The Megamp Accelerator and Beam Experiment (MABE) was the technology development testbed for the multiple beam, linear induction accelerator approach for Hermes III, a new 20 MeV, 0.8 MA, 40 ns accelerator being developed at Sandia for gamma-ray simulation. Experimental studies of a high-current, single-beam accelerator (8 MeV, 80 kA), and a nine-beam injector (1.4 MeV, 25 kA/beam) have been completed, and experiments on a nine-beam linear induction accelerator are in progress. A two-beam linear induction accelerator is designed and will be built as a gamma-ray simulator to be used in parallel with Hermes III. The MABE pulsed power systemmore » and accelerator for the multiple beam experiments is described. Results from these experiments and the two-beam design are discussed. 11 refs., 6 figs.« less

  8. Proof-of-principle test of coherent-state continuous variable quantum key distribution through turbulent atmosphere (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Derkach, Ivan D.; Peuntinger, Christian; Ruppert, László; Heim, Bettina; Gunthner, Kevin; Usenko, Vladyslav C.; Elser, Dominique; Marquardt, Christoph; Filip, Radim; Leuchs, Gerd

    2016-10-01

    Continuous-variable quantum key distribution is a practical application of quantum information theory that is aimed at generation of secret cryptographic key between two remote trusted parties and that uses multi-photon quantum states as carriers of key bits. Remote parties share the secret key via a quantum channel, that presumably is under control of of an eavesdropper, and which properties must be taken into account in the security analysis. Well-studied fiber-optical quantum channels commonly possess stable transmittance and low noise levels, while free-space channels represent a simpler, less demanding and more flexible alternative, but suffer from atmospheric effects such as turbulence that in particular causes a non-uniform transmittance distribution referred to as fading. Nonetheless free-space channels, providing an unobstructed line-of-sight, are more apt for short, mid-range and potentially long-range (using satellites) communication and will play an important role in the future development and implementation of QKD networks. It was previously theoretically shown that coherent-state CV QKD should be in principle possible to implement over a free-space fading channel, but strong transmittance fluctuations result in the significant modulation-dependent channel excess noise. In this regime the post-selection of highly transmitting sub-channels may be needed, which can even restore the security of the protocol in the strongly turbulent channels. We now report the first proof-of-principle experimental test of coherent state CV QKD protocol using different levels Gaussian modulation over a mid-range (1.6-kilometer long) free-space atmospheric quantum channel. The transmittance of the link was characterized using intensity measurements for the reference but channel estimation using the modulated coherent states was also studied. We consider security against Gaussian collective attacks, that were shown to be optimal against CV QKD protocols . We assumed a

  9. The Student Course Experience among Online, Accelerated, and Traditional Courses

    ERIC Educational Resources Information Center

    Bielitz, Colleen L.

    2016-01-01

    The demand by the public for a wider variety of course formats has led to complexity in determining a course's optimal delivery format as many faculty members still believe that online and accelerated courses do not offer students an equivalent experience to traditional face to face instruction. The purpose of this quantitative, comparative study…

  10. On violations of Le Chatelier's principle for a temperature change in small systems observed for short times

    NASA Astrophysics Data System (ADS)

    Dasmeh, Pouria; Searles, Debra J.; Ajloo, Davood; Evans, Denis J.; Williams, Stephen R.

    2009-12-01

    Le Chatelier's principle states that when a system is disturbed, it will shift its equilibrium to counteract the disturbance. However for a chemical reaction in a small, confined system, the probability of observing it proceed in the opposite direction to that predicted by Le Chatelier's principle, can be significant. This work gives a molecular level proof of Le Chatelier's principle for the case of a temperature change. Moreover, a new, exact mathematical expression is derived that is valid for arbitrary system sizes and gives the relative probability that a single experiment will proceed in the endothermic or exothermic direction, in terms of a microscopic phase function. We show that the average of the time integral of this function is the maximum possible value of the purely irreversible entropy production for the thermal relaxation process. Our result is tested against computer simulations of the unfolding of a polypeptide. We prove that any equilibrium reaction mixture on average responds to a temperature increase by shifting its point of equilibrium in the endothermic direction.

  11. Robust control of accelerators

    NASA Astrophysics Data System (ADS)

    Joel, W.; Johnson, D.; Chaouki, Abdallah T.

    1991-07-01

    The problem of controlling the variations in the rf power system can be effectively cast as an application of modern control theory. Two components of this theory are obtaining a model and a feedback structure. The model inaccuracies influence the choice of a particular controller structure. Because of the modelling uncertainty, one has to design either a variable, adaptive controller or a fixed, robust controller to achieve the desired objective. The adaptive control scheme usually results in very complex hardware; and, therefore, shall not be pursued in this research. In contrast, the robust control method leads to simpler hardware. However, robust control requires a more accurate mathematical model of the physical process than is required by adaptive control. Our research at the Los Alamos National Laboratory (LANL) and the University of New Mexico (UNM) has led to the development and implementation of a new robust rf power feedback system. In this article, we report on our research progress. In section 1, the robust control problem for the rf power system and the philosophy adopted for the beginning phase of our research is presented. In section 2, the results of our proof-of-principle experiments are presented. In section 3, we describe the actual controller configuration that is used in LANL FEL physics experiments. The novelty of our approach is that the control hardware is implemented directly in rf. without demodulating, compensating, and then remodulating.

  12. Experiments in sensing transient rotational acceleration cues on a flight simulator

    NASA Technical Reports Server (NTRS)

    Parrish, R. V.

    1979-01-01

    Results are presented for two transient motion sensing experiments which were motivated by the identification of an anomalous roll cue (a 'jerk' attributed to an acceleration spike) in a prior investigation of realistic fighter motion simulation. The experimental results suggest the consideration of several issues for motion washout and challenge current sensory system modeling efforts. Although no sensory modeling effort is made it is argued that such models must incorporate the ability to handle transient inputs of short duration (some of which are less than the accepted latency times for sensing), and must represent separate channels for rotational acceleration and velocity sensing.

  13. Helicon Plasma Injector and Ion Cyclotron Acceleration Development in the VASIMR Experiment

    NASA Technical Reports Server (NTRS)

    Squire, Jared P.; Chang, Franklin R.; Jacobson, Verlin T.; McCaskill, Greg E.; Bengtson, Roger D.; Goulding, Richard H.

    2000-01-01

    In the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) radio frequency (rf) waves both produce the plasma and then accelerate the ions. The plasma production is done by action of helicon waves. These waves are circular polarized waves in the direction of the electron gyromotion. The ion acceleration is performed by ion cyclotron resonant frequency (ICRF) acceleration. The Advanced Space Propulsion Laboratory (ASPL) is actively developing efficient helicon plasma production and ICRF acceleration. The VASIMR experimental device at the ASPL is called VX-10. It is configured to demonstrate the plasma production and acceleration at the 10kW level to support a space flight demonstration design. The VX-10 consists of three electromagnets integrated into a vacuum chamber that produce magnetic fields up to 0.5 Tesla. Magnetic field shaping is achieved by independent magnet current control and placement of the magnets. We have generated both helium and hydrogen high density (>10(exp 18) cu m) discharges with the helicon source. ICRF experiments are underway. This paper describes the VX-10 device, presents recent results and discusses future plans.

  14. A Phenomenological Investigation of Rural Superintendents' Experiences in the Application of Principle-Centered Leadership

    ERIC Educational Resources Information Center

    Davidson, Shelby L.

    2015-01-01

    This qualitative phenomenological research study used narrative inquiry to investigate rural superintendents' experiences with the application of principle-centered leadership in their districts. Ten superintendents from rural districts in east Texas were interviewed. Narratives were analyzed by organizing, describing, classifying, and…

  15. Studies of Ion Acceleration from Thin Solid-Density Targets on High-Intensity Lasers

    NASA Astrophysics Data System (ADS)

    Willis, Christopher R.

    Over the past two decades, a number of experiments have been performed demonstrating the acceleration of ions from the interaction of an intense laser pulse with a thin, solid density target. These ions are accelerated by quasi-static electric fields generated by energetic electrons produced at the front of the target, resulting in ion energies up to tens of MeV. These ions have been widely studied for a variety of potential applications ranging from treatment of cancer to the production of neutrons for advanced radiography techniques. However, realization of these applications will require further optimization of the maximum energy, spectrum, or species of the accelerated ions, which has been a primary focus of research to date. This thesis presents two experiments designed to optimize several characteristics of the accelerated ion beam. The first of these experiments took place on the GHOST laser system at the University of Texas at Austin, and was designed to demonstrate reliable acceleration of deuterium ions, as needed for the most efficient methods of neutron generation from accelerated ions. This experiment leveraged cryogenically cooled targets coated in D2 O ice to suppress the protons which typically dominate the accelerated ions, producing as many as 2 x 1010 deuterium ions per 1 J laser shot, exceeding the proton yield by an average ratio of 5:1. The second major experiment in this work was performed on the Scarlet laser system at The Ohio State University, and studied the accelerated ion energy, yield, and spatial distribution as a function of the target thickness. In principle, the peak energy increases with decreasing target thickness, with the thinnest targets accessing additional acceleration mechanisms which provide favorable scaling with the laser intensity. However, laser prepulse characteristics provide a lower bound for the target thickness, yielding an optimum target thickness for ion acceleration which is dependent on the laser system. This

  16. Synthesis of an optoelectronic system for tracking (OEST) the information track of the optical record carrier based on the acceleration control principle

    NASA Astrophysics Data System (ADS)

    Zalogin, Stanislav M.; Zalogin, M. S.

    1997-02-01

    The problem for construction of control algorithm in OEST the information track of the optical record carrier the realization of which is based on the use of accelerations is considered. Such control algorithms render the designed system the properties of adaptability, feeble sensitivity to the system parameter change and the action of disturbing forces what gives known advantages to information carriers with such system under operation in hard climate conditions as well as at maladjustment, workpieces wear and change of friction in the system. In the paper are investigated dynamic characteristics of a closed OEST, it is shown, that the designed stable system with given quality indices is a high-precision one. The validated recommendations as to design of control algorithms parameters are confirmed by results of mathematical simulation of controlled processes. The proposed methods for OEST synthesis on the basis of the control acceleration principle can be recommended for the use at industrial production of optical information record carriers.

  17. Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

    NASA Astrophysics Data System (ADS)

    Kafka, Gene

    The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with significant flexibility in mind, but without compromising cost efficiency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of different variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state of the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of-flight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.

  18. Design of a high-bunch-charge 112-MHz superconducting RF photoemission electron source

    NASA Astrophysics Data System (ADS)

    Xin, T.; Brutus, J. C.; Belomestnykh, Sergey A.; Ben-Zvi, I.; Boulware, C. H.; Grimm, T. L.; Hayes, T.; Litvinenko, Vladimir N.; Mernick, K.; Narayan, G.; Orfin, P.; Pinayev, I.; Rao, T.; Severino, F.; Skaritka, J.; Smith, K.; Than, R.; Tuozzolo, J.; Wang, E.; Xiao, B.; Xie, H.; Zaltsman, A.

    2016-09-01

    High-bunch-charge photoemission electron-sources operating in a continuous wave (CW) mode are required for many advanced applications of particle accelerators, such as electron coolers for hadron beams, electron-ion colliders, and free-electron lasers. Superconducting RF (SRF) has several advantages over other electron-gun technologies in CW mode as it offers higher acceleration rate and potentially can generate higher bunch charges and average beam currents. A 112 MHz SRF electron photoinjector (gun) was developed at Brookhaven National Laboratory to produce high-brightness and high-bunch-charge bunches for the coherent electron cooling proof-of-principle experiment. The gun utilizes a quarter-wave resonator geometry for assuring beam dynamics and uses high quantum efficiency multi-alkali photocathodes for generating electrons.

  19. Torque-based optimal acceleration control for electric vehicle

    NASA Astrophysics Data System (ADS)

    Lu, Dongbin; Ouyang, Minggao

    2014-03-01

    The existing research of the acceleration control mainly focuses on an optimization of the velocity trajectory with respect to a criterion formulation that weights acceleration time and fuel consumption. The minimum-fuel acceleration problem in conventional vehicle has been solved by Pontryagin's maximum principle and dynamic programming algorithm, respectively. The acceleration control with minimum energy consumption for battery electric vehicle(EV) has not been reported. In this paper, the permanent magnet synchronous motor(PMSM) is controlled by the field oriented control(FOC) method and the electric drive system for the EV(including the PMSM, the inverter and the battery) is modeled to favor over a detailed consumption map. The analytical algorithm is proposed to analyze the optimal acceleration control and the optimal torque versus speed curve in the acceleration process is obtained. Considering the acceleration time, a penalty function is introduced to realize a fast vehicle speed tracking. The optimal acceleration control is also addressed with dynamic programming(DP). This method can solve the optimal acceleration problem with precise time constraint, but it consumes a large amount of computation time. The EV used in simulation and experiment is a four-wheel hub motor drive electric vehicle. The simulation and experimental results show that the required battery energy has little difference between the acceleration control solved by analytical algorithm and that solved by DP, and is greatly reduced comparing with the constant pedal opening acceleration. The proposed analytical and DP algorithms can minimize the energy consumption in EV's acceleration process and the analytical algorithm is easy to be implemented in real-time control.

  20. Satellite Test of the Equivalence Principle as a Probe of Modified Newtonian Dynamics.

    PubMed

    Pereira, Jonas P; Overduin, James M; Poyneer, Alexander J

    2016-08-12

    The proposed satellite test of the equivalence principle (STEP) will detect possible violations of the weak equivalence principle by measuring relative accelerations between test masses of different composition with a precision of one part in 10^{18}. A serendipitous by-product of the experimental design is that the absolute or common-mode acceleration of the test masses is also measured to high precision as they oscillate along a common axis under the influence of restoring forces produced by the position sensor currents, which in drag-free mode lead to Newtonian accelerations as small as 10^{-14}  g. This is deep inside the low-acceleration regime where modified Newtonian dynamics (MOND) diverges strongly from the Newtonian limit of general relativity. We show that MOND theories (including those based on the widely used "n family" of interpolating functions as well as the covariant tensor-vector-scalar formulation) predict an easily detectable increase in the frequency of oscillations of the STEP test masses if the strong equivalence principle holds. If it does not hold, MOND predicts a cumulative increase in oscillation amplitude which is also detectable. STEP thus provides a new and potentially decisive test of Newton's law of inertia, as well as the equivalence principle in both its strong and weak forms.

  1. EDITORIAL: Metrological Aspects of Accelerator Technology and High Energy Physics Experiments

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.; Pozniak, Krzysztof T.

    2007-08-01

    The subject of this special feature in Measurement Science and Technology concerns measurement methods, devices and subsystems, both hardware and software aspects, applied in large experiments of high energy physics (HEP) and superconducting RF accelerator technology (SRF). These experiments concern mainly the physics of elementary particles or the building of new machines and detectors. The papers present practical examples of applied solutions in large, contemporary, international research projects such as HERA, LHC, FLASH, XFEL, ILC and others. These machines are unique in their global scale and consist of extremely dedicated apparatus. The apparatus is characterized by very large dimensions, a considerable use of resources and a high level of overall technical complexity. They possess a large number of measurement channels (ranging from thousands to over 100 million), are characterized by fast of processing of measured data and high measurement accuracies, and work in quite adverse environments. The measurement channels cooperate with a large number of different sensors of momenta, energies, trajectories of elementary particles, electron, proton and photon beam profiles, accelerating fields in resonant cavities, and many others. The provision of high quality measurement systems requires the designers to use only the most up-to-date technical solutions, measurement technologies, components and devices. Research work in these demanding fields is a natural birthplace of new measurement methods, new data processing and acquisition algorithms, complex, networked measurement system diagnostics and monitoring. These developments are taking place in both hardware and software layers. The chief intention of this special feature is that the papers represent equally some of the most current metrology research problems in HEP and SRF. The accepted papers have been divided into four topical groups: superconducting cavities (4 papers), low level RF systems (8 papers

  2. Guidelines for Proof Test Analysis

    NASA Technical Reports Server (NTRS)

    Chell, G. G.; McClung, R. C.; Kuhlman, C. J.; Russell, D. A.; Garr, K.; Donnelly, B.

    1999-01-01

    These guidelines integrate state-of-the-art elastic-plastic fracture mechanics (EPFM) and proof test implementation issues into a comprehensive proof test analysis procedure in the form of a road map which identifies the types of data, fracture mechanics based parameters, and calculations needed to perform flaw screening and minimum proof load analyses of fracture critical components. Worked examples are presented to illustrate the application of the road map to proof test analysis. The state-of-the art fracture technology employed in these guidelines is based on the EPFM parameter, J, and a pictorial representation of a J fracture analysis, called the failure assessment diagram (FAD) approach. The recommended fracture technology is validated using finite element J results, and laboratory and hardware fracture test results on the nickel-based superalloy Inconel 718, the aluminum alloy 2024-T3511, and ferritic pressure vessel steels. In all cases the laboratory specimens and hardware failed by ductile mechanisms. Advanced proof test analyses involving probability analysis and multiple-cycle proof testing (MCPT) are addressed. Finally, recommendations are provided on how to account for the effects of the proof test overload on subsequent service fatigue and fracture behaviors.

  3. Granularity analysis for mathematical proofs.

    PubMed

    Schiller, Marvin R G

    2013-04-01

    Mathematical proofs generally allow for various levels of detail and conciseness, such that they can be adapted for a particular audience or purpose. Using automated reasoning approaches for teaching proof construction in mathematics presupposes that the step size of proofs in such a system is appropriate within the teaching context. This work proposes a framework that supports the granularity analysis of mathematical proofs, to be used in the automated assessment of students' proof attempts and for the presentation of hints and solutions at a suitable pace. Models for granularity are represented by classifiers, which can be generated by hand or inferred from a corpus of sample judgments via machine-learning techniques. This latter procedure is studied by modeling granularity judgments from four experts. The results provide support for the granularity of assertion-level proofs but also illustrate a degree of subjectivity in assessing step size. Copyright © 2013 Cognitive Science Society, Inc.

  4. Magnetic particle imaging: from proof of principle to preclinical applications

    NASA Astrophysics Data System (ADS)

    Knopp, T.; Gdaniec, N.; Möddel, M.

    2017-07-01

    Tomographic imaging has become a mandatory tool for the diagnosis of a majority of diseases in clinical routine. Since each method has its pros and cons, a variety of them is regularly used in clinics to satisfy all application needs. Magnetic particle imaging (MPI) is a relatively new tomographic imaging technique that images magnetic nanoparticles with a high spatiotemporal resolution in a quantitative way, and in turn is highly suited for vascular and targeted imaging. MPI was introduced in 2005 and now enters the preclinical research phase, where medical researchers get access to this new technology and exploit its potential under physiological conditions. Within this paper, we review the development of MPI since its introduction in 2005. Besides an in-depth description of the basic principles, we provide detailed discussions on imaging sequences, reconstruction algorithms, scanner instrumentation and potential medical applications.

  5. Metal-assisted and microwave accelerated-evaporative crystallization: Application to lysozyme protein

    NASA Astrophysics Data System (ADS)

    Mauge-Lewis, Kevin

    In response to the growing need for new crystallization techniques that afford for rapid processing times along with control over crystal size and distribution, the Aslan Research Group has recently demonstrated the use of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization MA-MAEC technique in conjunction with metal nanoparticles and nanostructures for the crystallization of amino acids and organic small molecules. In this study, we have employed the newly developed MA-MAEC technique to the accelerated crystallization of chicken egg-white lysozyme on circular crystallization platforms in order to demonstrate the proof-of-principle application of the method for protein crystallization. The circular crystallization platforms are constructed in-house from poly (methyl methacrylate) (PMMA) and silver nanoparticle films (SNFs), indium tin oxide (ITO) and iron nano-columns. In this study, we prove the MA-MAEC method to be a more effective technique in the rapid crystallization of macromolecules in comparison to other conventional methods. Furthermore, we demonstrate the use of the novel iCrystal system, which incorporates the use of continuous, low wattage heating to facilitate the rapid crystallization of the lysozyme while still retaining excellent crystal quality. With the incorporation of the iCrystal system, we observe crystallization times that are even shorter than those produced by the MA-MAEC technique using a conventional microwave oven in addition to significantly improved crystal quality.

  6. Changes in canine cerebral perfusion after accelerated high frequency repetitive transcranial magnetic stimulation (HF-rTMS): A proof of concept study.

    PubMed

    Dockx, R; Baeken, C; Duprat, R; De Vos, F; Saunders, J H; Polis, I; Audenaert, K; Peremans, K

    2018-04-01

    Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for several neuropsychiatric disorders in human beings, but the neurobiological effects of rTMS in dogs have not been investigated to date. A proof of concept study was designed to evaluate the effect of rTMS on cerebral perfusion, measured with single photon emission computed tomography (SPECT), in dogs. An accelerated high frequency (aHF)-rTMS (20Hz) protocol was applied to the canine left frontal cortex. To accurately target this area, eight dogs underwent a 3 Tesla magnetic resonance imaging (MRI) scan before stimulation. The left frontal cortex was subjected to five consecutive aHF-rTMS sessions with a figure-of-eight coil designed for human beings at an intensity of 110% of the motor threshold. The dogs underwent 99m Tc-d,1 hexamethylpropylene amine oxime (HMPAO) SPECT scans 1 week prior to and 1day after the stimulations. Perfusion indices (PIs) were determined semi-quantitatively; aHF-rTMS resulted in significantly increased PIs in the left frontal cortex and the subcortical region, whereas no significant differences were noted for the other regions. Behaviour was not influenced by the stimulation sessions. As has been observed in human beings, aHF-rTMS applied to the left frontal cortex alters regional cerebral perfusion in dogs. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies.

    PubMed

    Andrade, E L; Bento, A F; Cavalli, J; Oliveira, S K; Freitas, C S; Marcon, R; Schwanke, R C; Siqueira, J M; Calixto, J B

    2016-10-24

    This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification of leader molecules and their optimization, the selection of a candidate substance for clinical development, and the use of animal models during the early studies of proof-of-concept (or principle). This report also discusses the relevance of validated and predictive animal models selection, as well as the correct use of animal tests concerning the experimental design, execution and interpretation, which affect the reproducibility, quality and reliability of non-clinical studies necessary to translate to and support clinical studies. Collectively, improving these aspects will certainly contribute to the robustness of both scientific publications and the translation of new substances to clinical development.

  8. A Framework for Proofs and Refutations in School Mathematics: Increasing Content by Deductive Guessing

    ERIC Educational Resources Information Center

    Komatsu, Kotaro

    2016-01-01

    The process of proofs and refutations described by Lakatos is essential in school mathematics to provide students with an opportunity to experience how mathematical knowledge develops dynamically within the discipline of mathematics. In this paper, a framework for describing student processes of proofs and refutations is constructed using a set of…

  9. 30 CFR 778.21 - Proof of publication.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Proof of publication. 778.21 Section 778.21....21 Proof of publication. A copy of the newspaper advertisements of the application for a permit, significant revision of a permit, or renewal of a permit, or proof of publication of the advertisements which...

  10. Analyzing radial acceleration with a smartphone acceleration sensor

    NASA Astrophysics Data System (ADS)

    Vogt, Patrik; Kuhn, Jochen

    2013-03-01

    This paper continues the sequence of experiments using the acceleration sensor of smartphones (for description of the function and the use of the acceleration sensor, see Ref. 1) within this column, in this case for analyzing the radial acceleration.

  11. An experiment to measure the mass density of a plasma armature

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rogers, J.W.; Thomas, K.A.; Clothiaux, E.J.

    1991-01-01

    In this paper a diagnostic technique for determining the mass density, and possibly the plasma composition, of the plasma armature in the MIDI-3 free-running arc device is described. The armature consists primarily of the components of polythylene and copper, and it can reach velocities in excess of 8 km/sec. The approach in this proof-of-principle experiment utilizes a flash x-ray source with x rays having energies from 3 keV to 20 keV, an elliptical x-ray crystal spectrometer, and an appropriate detector array and data acquisition system.

  12. Development of bipolar-pulse accelerator for intense pulsed ion beam acceleration

    NASA Astrophysics Data System (ADS)

    Masugata, Katsumi; Shimizu, Yuichro; Fujioka, Yuhki; Kitamura, Iwao; Tanoue, Hisao; Arai, Kazuo

    2004-12-01

    To improve the purity of intense pulsed ion beams, a new type of pulsed ion beam accelerator named "bipolar pulse accelerator" was proposed. To confirm the principle of the accelerator a prototype of the experimental system was developed. The system utilizes By type magnetically insulated acceleration gap and operated with single polar negative pulse. A coaxial gas puff plasma gun was used as an ion source, which was placed inside the grounded anode. Source plasma (nitrogen) of current density ≈25 A/cm2, duration ≈1.5 μs was injected into the acceleration gap by the plasma gun. The ions were successfully accelerated from the grounded anode to the drift tube by applying negative pulse of voltage 240 kV, duration 100 ns to the drift tube. Pulsed ion beam of current density ≈40 A/cm2, duration ≈50 ns was obtained at 41 mm downstream from the anode surface. To evaluate the irradiation effect of the ion beam to solid material, an amorphous silicon thin film of thickness ≈500 nm was used as the target, which was deposited on the glass substrate. The film was found to be poly-crystallized after 4-shots of the pulsed nitrogen ion beam irradiation.

  13. Microengineering Laser Plasma Interactions at Relativistic Intensities.

    PubMed

    Jiang, S; Ji, L L; Audesirk, H; George, K M; Snyder, J; Krygier, A; Poole, P; Willis, C; Daskalova, R; Chowdhury, E; Lewis, N S; Schumacher, D W; Pukhov, A; Freeman, R R; Akli, K U

    2016-02-26

    We report on the first successful proof-of-principle experiment to manipulate laser-matter interactions on microscales using highly ordered Si microwire arrays. The interaction of a high-contrast short-pulse laser with a flat target via periodic Si microwires yields a substantial enhancement in both the total and cutoff energies of the produced electron beam. The self-generated electric and magnetic fields behave as an electromagnetic lens that confines and guides electrons between the microwires as they acquire relativistic energies via direct laser acceleration.

  14. Microengineering Laser Plasma Interactions at Relativistic Intensities

    NASA Astrophysics Data System (ADS)

    Jiang, S.; Ji, L. L.; Audesirk, H.; George, K. M.; Snyder, J.; Krygier, A.; Poole, P.; Willis, C.; Daskalova, R.; Chowdhury, E.; Lewis, N. S.; Schumacher, D. W.; Pukhov, A.; Freeman, R. R.; Akli, K. U.

    2016-02-01

    We report on the first successful proof-of-principle experiment to manipulate laser-matter interactions on microscales using highly ordered Si microwire arrays. The interaction of a high-contrast short-pulse laser with a flat target via periodic Si microwires yields a substantial enhancement in both the total and cutoff energies of the produced electron beam. The self-generated electric and magnetic fields behave as an electromagnetic lens that confines and guides electrons between the microwires as they acquire relativistic energies via direct laser acceleration.

  15. Application of photon detectors in the VIP2 experiment to test the Pauli Exclusion Principle

    NASA Astrophysics Data System (ADS)

    Pichler, A.; Bartalucci, S.; Bazzi, M.; Bertolucci, S.; Berucci, C.; Bragadireanu, M.; Cargnelli, M.; Clozza, A.; Curceanu, C.; De Paolis, L.; Di Matteo, S.; D'Ufflzi, A.; Egger, J.-P.; Guaraldo, C.; Iliescu, M.; Ishiwatari, T.; Laubenstein, M.; Marton, J.; Milotti, E.; Pietreanu, D.; Piscicchia, K.; Ponta, T.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, D.; Sirghi, F.; Sperandio, L.; Vazquez-Doce, O.; Widmann, E.; Zmeskal, J.

    2016-05-01

    The Pauli Exclusion Principle (PEP) was introduced by the austrian physicist Wolfgang Pauli in 1925. Since then, several experiments have checked its validity. From 2006 until 2010, the VIP (Violation of the Pauli Principle) experiment took data at the LNGS underground laboratory to test the PEP. This experiment looked for electronic 2p to Is transitions in copper, where 2 electrons are in the Is state before the transition happens. These transitions violate the PEP. The lack of detection of X-ray photons coming from these transitions resulted in a preliminary upper limit for the violation of the PEP of 4.7 × 10-29. Currently, the successor experiment VIP2 is under preparation. The main improvements are, on one side, the use of Silicon Drift Detectors (SDDs) as X-ray photon detectors. On the other side an active shielding is implemented, which consists of plastic scintillator bars read by Silicon Photomultipliers (SiPMs). The employment of these detectors will improve the upper limit for the violation of the PEP by around 2 orders of magnitude.

  16. Evaluation of the concept of pressure proof testing fuselage structures

    NASA Technical Reports Server (NTRS)

    Harris, Charles E.; Orringer, Oscar

    1991-01-01

    The FAA and NASA have recently completed independent technical evaluations of the concept of pressure proof testing the fuselage of commercial transport airplanes. The results of these evaluations are summarized. The objectives of the evaluations were to establish the potential benefit of the pressure proof test, to quantify the most desirable proof test pressure, and to quantify the required proof test interval. The focus of the evaluations was on multiple-site cracks extending from adjacent rivet holes of a typical fuselage longitudinal lap splice joint. The FAA and NASA do not support pressure proof testing the fuselage of aging commercial transport aircraft. The argument against proof testing is as follows: (1) a single proof test does not insure an indefinite life; therefore, the proof test must be repeated at regular intervals; (2) for a proof factor of 1.33, the required proof test interval must be below 300 flights to account for uncertainties in the evaluation; (3) conducting the proof test at a proof factor of 1.5 would considerably exceed the fuselage design limit load; therefore, it is not consistent with accepted safe practices; and (4) better safety can be assured by implementing enhanced nondestructive inspection requirements, and adequate reliability can be achieved by an inspection interval several times longer than the proof test interval.

  17. Hydrological tracers using nanobiotechnology: proof of concept.

    PubMed

    Sharma, Asha N; Luo, Dan; Walter, M Todd

    2012-08-21

    In order to answer questions that involve differentiating among multiple and potentially interacting hydrological flowpaths, it would be ideal to use multiple tracers with identical transport properties that can nonetheless be distinguished from each other. This paper describes the development and proof of concept of a new kind of engineered tracer system that allows a large number of individual tracers to be simultaneously distinguished from one another. This new tracer is composed of polylactic acid (PLA) microspheres into which short strands of synthetic DNA and paramagnetic iron oxide nanoparticles are incorporated. The synthetic DNA serves as the "label" or "tag" in our tracers that allow us to distinguish one tracer from another, and paramagnetic iron oxide nanoparticles are included in the tracer to facilitate magnetic concentration of the tracers in potentially dilute water samples. Some potential advantages of this tracer concept include: virtually limitless uniquely labeled tracers, highly sensitive detection, and relatively moderate expense. Three proof-of-concept experiments at scales ranging from orders of 10 cm to 100 m demonstrated the use of the tracer system.

  18. 45 CFR 81.85 - Offer of proof.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Offer of proof. 81.85 Section 81.85 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRACTICE AND PROCEDURE FOR HEARINGS UNDER PART 80 OF THIS TITLE Hearing Procedures § 81.85 Offer of proof. An offer of proof made in connection with...

  19. 45 CFR 81.85 - Offer of proof.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Offer of proof. 81.85 Section 81.85 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRACTICE AND PROCEDURE FOR HEARINGS UNDER PART 80 OF THIS TITLE Hearing Procedures § 81.85 Offer of proof. An offer of proof made in connection with...

  20. RGLite, an interface between ROOT and gLite—proof on the grid

    NASA Astrophysics Data System (ADS)

    Malzacher, P.; Manafov, A.; Schwarz, K.

    2008-07-01

    Using the gLitePROOF package it is possible to perform PROOF-based distributed data analysis on the gLite Grid. The LHC experiments managed to run globally distributed Monte Carlo productions on the Grid, now the development of tools for data analysis is in the foreground. To grant access interfaces must be provided. The ROOT/PROOF framework is used as a starting point. Using abstract ROOT classes (TGrid, ...) interfaces can be implemented, via which Grid access from ROOT can be accomplished. A concrete implementation exists for the ALICE Grid environment AliEn. Within the D-Grid project an interface to the common Grid middleware of all LHC experiments, gLite, has been created. Therefore it is possible to query Grid File Catalogues from ROOT for the location of the data to be analysed. Grid jobs can be submitted into a gLite based Grid. The status of the jobs can be asked for, and their results can be obtained.

  1. A Technique of Teaching the Principle of Equivalence at Ground Level

    ERIC Educational Resources Information Center

    Lubrica, Joel V.

    2016-01-01

    This paper presents one way of demonstrating the Principle of Equivalence in the classroom. Teaching the Principle of Equivalence involves someone experiencing acceleration through empty space, juxtaposed with the daily encounter with gravity. This classroom activity is demonstrated with a water-filled bottle containing glass marbles and…

  2. The precautionary principle within European Union public health policy. The implementation of the principle under conditions of supranationality and citizenship.

    PubMed

    Antonopoulou, Lila; van Meurs, Philip

    2003-11-01

    The present study examines the precautionary principle within the parameters of public health policy in the European Union, regarding both its meaning, as it has been shaped by relevant EU institutions and their counterparts within the Member States, and its implementation in practice. In the initial section I concentrate on the methodological question of "scientific uncertainty" concerning the calculation of risk and possible damage. Calculation of risk in many cases justifies the adopting of preventive measures, but, as it is argued, the principle of precaution and its implementation cannot be wholly captured by a logic of calculation; such a principle does not only contain scientific uncertainty-as the preventive principle does-but it itself is generated as a principle by this scientific uncertainty, recognising the need for a society to act. Thus, the implementation of the precautionary principle is also a simultaneous search for justification of its status as a principle. This justification would result in the adoption of precautionary measures against risk although no proof of this principle has been produced based on the "cause-effect" model. The main part of the study is occupied with an examination of three cases from which the stance of the official bodies of the European Union towards the precautionary principle and its implementation emerges: the case of the "mad cows" disease, the case of production and commercialization of genetically modified foodstuffs. The study concludes with the assessment that the effective implementation of the precautionary principle on a European level depends on the emergence of a concerned Europe-wide citizenship and its acting as a mechanism to counteract the material and social conditions that pose risks for human health.

  3. Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer.

    PubMed

    Trivillin, Verónica A; Pozzi, Emiliano C C; Colombo, Lucas L; Thorp, Silvia I; Garabalino, Marcela A; Monti Hughes, Andrea; González, Sara J; Farías, Rubén O; Curotto, Paula; Santa Cruz, Gustavo A; Carando, Daniel G; Schwint, Amanda E

    2017-11-01

    The aim of the present study was to evaluate, for the first time, the abscopal effect of boron neutron capture therapy (BNCT). Twenty-six BDIX rats were inoculated subcutaneously with 1 × 10 6 DHD/K12/TRb syngeneic colon cancer cells in the right hind flank. Three weeks post-inoculation, the right leg of 12 rats bearing the tumor nodule was treated with BPA-BNCT (BPA-Boronophenylalanine) at the RA-3 nuclear reactor located in Buenos Aires, Argentina, at an absorbed dose of 7.5 Gy to skin as the dose-limiting tissue. The remaining group of 14 tumor-bearing rats were left untreated and used as control. Two weeks post-BNCT, 1 × 10 6 DHD/K12/TRb cells were injected subcutaneously in the contralateral left hind flank of each of the 26 BDIX rats. Tumor volume in both legs was measured weekly for 7 weeks to determine response to BNCT in the right leg and to assess a potential influence of BNCT in the right leg on tumor development in the left leg. Within the BNCT group, a statistically significant reduction was observed in contralateral left tumor volume in animals whose right leg tumor responded to BNCT (post-treatment/pre-treatment tumor volume <1) versus animals who failed to respond (post/pre ≥1), i.e., 13 ± 15 vs 271 ± 128 mm 3 . In addition, a statistically significant reduction in contralateral left leg tumor volume was observed in BNCT-responsive animals (post/pre <1) vs untreated animals, i.e., 13 ± 15 vs 254 ± 251 mm 3 . The present study performed in a simple animal model provides proof of principle that the positive response of a tumor to BNCT is capable of inducing an abscopal effect.

  4. Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kafka, Gene

    2015-05-01

    The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with signi cant exibility in mind, but without compromising cost e ciency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of di erent variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state ofmore » the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of- ight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.« less

  5. An Experiment in ''Less Time, More Options": A Study of Accelerated University Students.

    ERIC Educational Resources Information Center

    Litwin, James L.; And Others

    This study investigated the characteristics and experiences of 59 college students accelerated from their freshman to their junior year. The students showed high academic performance and few social problems, but questions of personal identity remained problematic; the best single predictor of academic success was found to be freshman grade-point…

  6. RF synchronized short pulse laser ion source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fuwa, Yasuhiro, E-mail: fuwa@kyticr.kuicr.kyoto-u.ac.jp; Iwashita, Yoshihisa; Tongu, Hiromu

    A laser ion source that produces shortly bunched ion beam is proposed. In this ion source, ions are extracted immediately after the generation of laser plasma by an ultra-short pulse laser before its diffusion. The ions can be injected into radio frequency (RF) accelerating bucket of a subsequent accelerator. As a proof-of-principle experiment of the ion source, a RF resonator is prepared and H{sub 2} gas was ionized by a short pulse laser in the RF electric field in the resonator. As a result, bunched ions with 1.2 mA peak current and 5 ns pulse length were observed at themore » exit of RF resonator by a probe.« less

  7. GPU Acceleration of the Locally Selfconsistent Multiple Scattering Code for First Principles Calculation of the Ground State and Statistical Physics of Materials

    NASA Astrophysics Data System (ADS)

    Eisenbach, Markus

    The Locally Self-consistent Multiple Scattering (LSMS) code solves the first principles Density Functional theory Kohn-Sham equation for a wide range of materials with a special focus on metals, alloys and metallic nano-structures. It has traditionally exhibited near perfect scalability on massively parallel high performance computer architectures. We present our efforts to exploit GPUs to accelerate the LSMS code to enable first principles calculations of O(100,000) atoms and statistical physics sampling of finite temperature properties. Using the Cray XK7 system Titan at the Oak Ridge Leadership Computing Facility we achieve a sustained performance of 14.5PFlop/s and a speedup of 8.6 compared to the CPU only code. This work has been sponsored by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Material Sciences and Engineering Division and by the Office of Advanced Scientific Computing. This work used resources of the Oak Ridge Leadership Computing Facility, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC05-00OR22725.

  8. Cancer driver-passenger distinction via sporadic human and dog cancer comparison: a proof of principle study with colorectal cancer

    PubMed Central

    Tang, Jie; Li, Yaping; Lyon, Kenneth; Camps, Jordi; Dalton, Stephen; Ried, Thomas; Zhao, Shaying

    2014-01-01

    Herein we report a proof of principle study illustrating a novel dog-human comparison strategy that addresses a central aim of cancer research, namely cancer driver–passenger distinction. We previously demonstrated that sporadic canine colorectal cancers (CRCs) share similar molecular pathogenesis mechanisms as their human counterparts. In this study, we compared the genome-wide copy number abnormalities between 29 human- and 10 canine sporadic CRCs. This led to the identification of 73 driver candidate genes (DCGs), altered in both species and with 27 from the whole genome and 46 from dog-human genomic rearrangement breakpoint (GRB) regions, as well as 38 passenger candidate genes (PCGs), altered in humans only and located in GRB regions. We noted that DCGs significantly differ from PCGs in every analysis conducted to assess their cancer relevance and biological functions. Importantly, while PCGs are not enriched in any specific functions, DCGs possess significantly enhanced functionality closely associated with cell proliferation and death regulation, as well as with epithelial cell apicobasal polarity establishment/maintenance. These observations support the notion that, in sporadic CRCs of both species, cell polarity genes not only contribute in preventing cancer cell invasion and spreading, but also likely serve as tumor suppressors by modulating cell growth. This pilot study validates our novel strategy and has uncovered four new potential cell polarity and colorectal tumor suppressor genes (RASA3, NUPL1, DENND5A, and AVL9). Expansion of this study would make more driver-passenger distinctions for cancers with large genomic amplifications or deletions, and address key questions regarding the relationship between cancer pathogenesis and epithelial cell polarity control in mammals. PMID:23416983

  9. Cancer driver-passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer.

    PubMed

    Tang, J; Li, Y; Lyon, K; Camps, J; Dalton, S; Ried, T; Zhao, S

    2014-02-13

    Herein we report a proof-of-principle study illustrating a novel dog-human comparison strategy that addresses a central aim of cancer research, namely cancer driver-passenger distinction. We previously demonstrated that sporadic canine colorectal cancers (CRCs) share similar molecular pathogenesis mechanisms as their human counterparts. In this study, we compared the genome-wide copy number abnormalities between 29 human and 10 canine sporadic CRCs. This led to the identification of 73 driver candidate genes (DCGs), altered in both species, and with 27 from the whole genome and 46 from dog-human genomic rearrangement breakpoint (GRB) regions, as well as 38 passenger candidate genes (PCGs), altered in humans only and located in GRB regions. We noted that DCGs significantly differ from PCGs in every analysis conducted to assess their cancer relevance and biological functions. Importantly, although PCGs are not enriched in any specific functions, DCGs possess significantly enhanced functionality closely associated with cell proliferation and death regulation, as well as with epithelial cell apicobasal polarity establishment/maintenance. These observations support the notion that, in sporadic CRCs of both species, cell polarity genes not only contribute in preventing cancer cell invasion and spreading, but also likely serve as tumor suppressors by modulating cell growth. This pilot study validates our novel strategy and has uncovered four new potential cell polarity and colorectal tumor suppressor genes (RASA3, NUPL1, DENND5A and AVL9). Expansion of this study would make more driver-passenger distinctions for cancers with large genomic amplifications or deletions, and address key questions regarding the relationship between cancer pathogenesis and epithelial cell polarity control in mammals.

  10. Who Wants Proof?

    ERIC Educational Resources Information Center

    Ball, Derek

    2002-01-01

    People are inclined to desire proof of theories if they have developed a certain philosophical style when they are quite young. It is a style that questions the authority for things, so that they can hold fast to what is good. Regarding mathematical proof, this author argues that it is only those who are prepared to take their own authority for…

  11. 31 CFR 341.4 - Proof of purchase.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Proof of purchase. 341.4 Section 341... BONDS § 341.4 Proof of purchase. At the time a Retirement Plan Bond is issued, the issuing agent will... name the bond is inscribed, to the registered owner as well, proof of the purchase on Form PD 3550. The...

  12. Adult Learners' Experiences in Accelerated Degree-Completion Programs at Christian Colleges: Transactions and Transformations

    ERIC Educational Resources Information Center

    Decker, Allyn

    2017-01-01

    The aim of this qualitative study was to investigate the lived experiences of adult learners at 4 Christian colleges in Indiana who desired to pursue bachelor and associate degrees in accelerated programs. The growing trend of accelerated programming exists to meet the needs of a growing number of adults who believe that earning an academic…

  13. Lockheed design of a wind satellite (WINDSAT) experiment

    NASA Technical Reports Server (NTRS)

    Osmundson, John S.; Martin, Stephen C.

    1985-01-01

    WINDSAT is a proposed space based global wind measuring system. A Shuttleborne experiment is proposed as a proof of principle demonstration before development of a full operational system. WINDSAT goals are to measure wind speed and direction to + or - 1 m/s and 10 deg accuracy over the entire earth from 0 to 20 km altitude with 1 km altitude resolution. The wind measuring instrument is a coherent lidar incorporating a pulsed CO2 TEA laser transmitter and a continuously scanning 1.25 m diameter optical system. The wind speed is measured by heterodyne detecting the backscattered return laser radiation and measuring this frequency shift.

  14. Analysis of the Cognitive Unity or Rupture between Conjecture and Proof When Learning to Prove on a Grade 10 Trigonometry Course

    ERIC Educational Resources Information Center

    Fiallo, Jorge; Gutiérrez, Angel

    2017-01-01

    We present results from a classroom-based intervention designed to help a class of grade 10 students (14-15 years old) learn proof while studying trigonometry in a dynamic geometry software environment. We analysed some students' solutions to conjecture-and-proof problems that let them gain experience in stating conjectures and developing proofs.…

  15. Development of a small prototype for a proof-of-concept of OpenPET imaging

    NASA Astrophysics Data System (ADS)

    Yamaya, Taiga; Yoshida, Eiji; Inaniwa, Taku; Sato, Shinji; Nakajima, Yasunori; Wakizaka, Hidekatsu; Kokuryo, Daisuke; Tsuji, Atsushi; Mitsuhashi, Takayuki; Kawai, Hideyuki; Tashima, Hideaki; Nishikido, Fumihiko; Inadama, Naoko; Murayama, Hideo; Haneishi, Hideaki; Suga, Mikio; Kinouchi, Shoko

    2011-02-01

    The OpenPET geometry is our new idea to visualize a physically opened space between two detector rings. In this paper, we developed the first small prototype to show a proof-of-concept of OpenPET imaging. Two detector rings of 110 mm diameter and 42 mm axial length were placed with a gap of 42 mm. The basic imaging performance was confirmed through phantom studies; the open imaging was realized at the cost of slight loss of axial resolution and 24% loss of sensitivity. For a proof-of-concept of PET image-guided radiation therapy, we carried out the in-beam tests with 11C radioactive beam irradiation in the heavy ion medical accelerator in Chiba to visualize in situ distribution of primary particles stopped in a phantom. We showed that PET images corresponding to dose distribution were obtained. For an initial proof-of-concept of real-time multimodal imaging, we measured a tumor-inoculated mouse with 18F-FDG, and an optical image of the mouse body surface was taken during the PET measurement by inserting a digital camera in the ring gap. We confirmed that the tumor in the gap was clearly visualized. The result also showed the extension effect of an axial field-of-view (FOV); a large axial FOV of 126 mm was obtained with the detectors that originally covered only an 84 mm axial FOV. In conclusion, our initial imaging studies showed promising performance of the OpenPET.

  16. Stork Color Proofing Technology

    NASA Astrophysics Data System (ADS)

    Ekman, C. Frederick

    1989-04-01

    For the past few years, Stork Colorproofing B.V. has been marketing an analog color proofing system in Europe based on electrophoto-graphic technology it pioneered for the purpose of high resolution, high fidelity color imaging in the field of the Graphic Arts. Based in part on this technology, it will make available on a commercial basis a digital color proofing system in 1989. Proofs from both machines will provide an exact reference for the user and will look, feel, and behave in a reproduction sense like the printed press sheet.

  17. Educational activities with a tandem accelerator

    NASA Astrophysics Data System (ADS)

    Casolaro, P.; Campajola, L.; Balzano, E.; D'Ambrosio, E.; Figari, R.; Vardaci, E.; La Rana, G.

    2018-05-01

    Selected experiments in fundamental physics have been proposed for many years at the Tandem Accelerator of the University of Napoli ‘Federico II’s Department of Physics as a part of a one-semester laboratory course for graduate students. The aim of this paper is to highlight the educational value of the experimental realization of the nuclear reaction 19F(p,α)16O. With the purpose of verifying the mass-energy equivalence principle, different aspects of both classical and modern physics can be investigated, e.g. conservation laws, atomic models, nuclear physics applications to compositional analysis, nuclear cross-section, Q-value and nuclear spectroscopic analysis.

  18. Batch Proving and Proof Scripting in PVS

    NASA Technical Reports Server (NTRS)

    Munoz, Cesar A.

    2007-01-01

    The batch execution modes of PVS are powerful, but highly technical, features of the system that are mostly accessible to expert users. This paper presents a PVS tool, called ProofLite, that extends the theorem prover interface with a batch proving utility and a proof scripting notation. ProofLite enables a semi-literate proving style where specification and proof scripts reside in the same file. The goal of ProofLite is to provide batch proving and proof scripting capabilities to regular, non-expert, users of PVS.

  19. The Impact of Learning Styles on Achievement in Principles of Microeconomics: A Natural Experiment

    ERIC Educational Resources Information Center

    Terregrossa, Ralph; Englander, Fred; Englander, Valerie

    2009-01-01

    This study investigates how a natural experiment occurring in the teaching of principles of microeconomics allows a test of the Dunn and Dunn learning styles model (Dunn & Griggs, 2000). The material for the first exam, based on essential definitions and theoretical foundations, was taught in a conventional, inductive style, more compatible with…

  20. The Explanation of the Pauli Exclusion Principle

    NASA Astrophysics Data System (ADS)

    Vasiliev, Victor; Moon, Russell

    2006-11-01

    Using the principles of the Vortex Theory, the construction of the alpha particle, and the theory that the nucleus is constructed out of alpha particles, the explanation of the Pauli Exclusion Principle is explained. If protons and electrons are connected to each other via fourth dimensional vortices, they spin in opposite directions. Since the alpha particle possesses two protons possessing opposite spins, their electrons also possess opposite spins. With a nucleus constructed out of alpha particles, all paired electrons in shells and sub-shells will spin in opposite directions. 1. Victor Vasiliev, Russell Moon. Controversy surrounding the Experiment conducted to prove the Vortex Theory, 2006 8th Annual Meeting of the Northwest Section, May 18-20, 2006, University of Puget Sound, Tacoma, Washington, USA, Abstract C1.00009. 2. Russell Moon. To the Photon Acceleration Effect, 2006 Texas Section APS/AAPT/SPS Joint Spring Meeting, Thursday--Saturday, March 23--25, 2006; San Angelo, Texas, Abstract: POS.00008. 3. Russell Moon, Fabian Calvo, Victor Vasiliev. The Neutral Pentaquark, 2006 APS March Meeting, March 13-17, Baltimore, MD, USA, Session Q1: GENERAL POSTER SESSION, Abstract Q1.00147.

  1. An Experiment in "Less Time": A Study of Students Accelerated to Junior Status

    ERIC Educational Resources Information Center

    Litwin, James L.; And Others

    1975-01-01

    As the result of a time-shortened degree experiment, 31 end-of-year freshmen were accelerated to junior status. The students showed high academic performance and few social problems, but questions of personal identity remained problematic. The best single predictor of academic success in the junior year was the freshman grade point average.…

  2. The Pygmalion Principle: The Practicum Expectations and Experiences of Mature Aged Student Teachers

    ERIC Educational Resources Information Center

    Etherington, Matthew

    2011-01-01

    This study was part of a larger on-going study that is examining the Pygmalion Principle for the practicum experiences of six mature-age student-teachers. The participants are former graduates with university degrees and aged from 36 to 49. They have extensive career backgrounds unrelated to classroom teaching. For this part of the larger study,…

  3. Principles of Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Landé, Alfred

    2013-10-01

    Preface; Introduction: 1. Observation and interpretation; 2. Difficulties of the classical theories; 3. The purpose of quantum theory; Part I. Elementary Theory of Observation (Principle of Complementarity): 4. Refraction in inhomogeneous media (force fields); 5. Scattering of charged rays; 6. Refraction and reflection at a plane; 7. Absolute values of momentum and wave length; 8. Double ray of matter diffracting light waves; 9. Double ray of matter diffracting photons; 10. Microscopic observation of ρ (x) and σ (p); 11. Complementarity; 12. Mathematical relation between ρ (x) and σ (p) for free particles; 13. General relation between ρ (q) and σ (p); 14. Crystals; 15. Transition density and transition probability; 16. Resultant values of physical functions; matrix elements; 17. Pulsating density; 18. General relation between ρ (t) and σ (є); 19. Transition density; matrix elements; Part II. The Principle of Uncertainty: 20. Optical observation of density in matter packets; 21. Distribution of momenta in matter packets; 22. Mathematical relation between ρ and σ; 23. Causality; 24. Uncertainty; 25. Uncertainty due to optical observation; 26. Dissipation of matter packets; rays in Wilson Chamber; 27. Density maximum in time; 28. Uncertainty of energy and time; 29. Compton effect; 30. Bothe-Geiger and Compton-Simon experiments; 31. Doppler effect; Raman effect; 32. Elementary bundles of rays; 33. Jeans' number of degrees of freedom; 34. Uncertainty of electromagnetic field components; Part III. The Principle of Interference and Schrödinger's equation: 35. Physical functions; 36. Interference of probabilities for p and q; 37. General interference of probabilities; 38. Differential equations for Ψp (q) and Xq (p); 39. Differential equation for фβ (q); 40. The general probability amplitude Φβ' (Q); 41. Point transformations; 42. General theorem of interference; 43. Conjugate variables; 44. Schrödinger's equation for conservative systems; 45. Schr

  4. An implementation of the maximum-caliber principle by replica-averaged time-resolved restrained simulations

    NASA Astrophysics Data System (ADS)

    Capelli, Riccardo; Tiana, Guido; Camilloni, Carlo

    2018-05-01

    Inferential methods can be used to integrate experimental informations and molecular simulations. The maximum entropy principle provides a framework for using equilibrium experimental data, and it has been shown that replica-averaged simulations, restrained using a static potential, are a practical and powerful implementation of such a principle. Here we show that replica-averaged simulations restrained using a time-dependent potential are equivalent to the principle of maximum caliber, the dynamic version of the principle of maximum entropy, and thus may allow us to integrate time-resolved data in molecular dynamics simulations. We provide an analytical proof of the equivalence as well as a computational validation making use of simple models and synthetic data. Some limitations and possible solutions are also discussed.

  5. An implementation of the maximum-caliber principle by replica-averaged time-resolved restrained simulations.

    PubMed

    Capelli, Riccardo; Tiana, Guido; Camilloni, Carlo

    2018-05-14

    Inferential methods can be used to integrate experimental informations and molecular simulations. The maximum entropy principle provides a framework for using equilibrium experimental data, and it has been shown that replica-averaged simulations, restrained using a static potential, are a practical and powerful implementation of such a principle. Here we show that replica-averaged simulations restrained using a time-dependent potential are equivalent to the principle of maximum caliber, the dynamic version of the principle of maximum entropy, and thus may allow us to integrate time-resolved data in molecular dynamics simulations. We provide an analytical proof of the equivalence as well as a computational validation making use of simple models and synthetic data. Some limitations and possible solutions are also discussed.

  6. Proof of concept of a novel SMA cage actuator

    NASA Astrophysics Data System (ADS)

    Deyer, Christopher W.; Brei, Diann E.

    2001-06-01

    Numerous industrial applications that currently utilize expensive solenoids or slow wax motors are good candidates for smart material actuation. Many of these applications require millimeter-scale displacement and low cost; thereby, eliminating piezoelectric technologies. Fortunately, there is a subset of these applications that can tolerate the slower response of shape memory alloys. This paper details a proof-of-concept study of a novel SMA cage actuator intended for proportional braking in commercial appliances. The chosen actuator architecture consists of a SMA wire cage enclosing a return spring. To develop an understanding of the influences of key design parameters on the actuator response time and displacement amplitude, a half-factorial 25 Design of Experiment (DOE) study was conducted utilizing eight differently configured prototypes. The DOE results guided the selection of the design parameters for the final proof-of-concept actuator. This actuator was built and experimentally characterized for stroke, proportional control and response time.

  7. On Anaphora and the Binding Principles in Categorial Grammar

    NASA Astrophysics Data System (ADS)

    Morrill, Glyn; Valentín, Oriol

    In type logical categorial grammar the analysis of an expression is a resource-conscious proof. Anaphora represents a particular challenge to this approach in that the antecedent resource is multiplied in the semantics. This duplication, which corresponds logically to the structural rule of contraction, may be treated lexically or syntactically. Furthermore, anaphora is subject to constraints, which Chomsky (1981) formulated as Binding Principles A, B, and C. In this paper we consider English anaphora in categorial grammar including reference to the binding principles. We invoke displacement calculus, modal categorial calculus, categorial calculus with limited contraction, and entertain addition of negation as failure.

  8. Assurance Cases for Proofs as Evidence

    NASA Technical Reports Server (NTRS)

    Chaki, Sagar; Gurfinkel, Arie; Wallnau, Kurt; Weinstock, Charles

    2009-01-01

    Proof-carrying code (PCC) provides a 'gold standard' for establishing formal and objective confidence in program behavior. However, in order to extend the benefits of PCC - and other formal certification techniques - to realistic systems, we must establish the correspondence of a mathematical proof of a program's semantics and its actual behavior. In this paper, we argue that assurance cases are an effective means of establishing such a correspondence. To this end, we present an assurance case pattern for arguing that a proof is free from various proof hazards. We also instantiate this pattern for a proof-based mechanism to provide evidence about a generic medical device software.

  9. Flexural strength of proof-tested and neutron-irradiated silicon carbide

    NASA Astrophysics Data System (ADS)

    Price, R. J.; Hopkins, G. R.

    1982-08-01

    Proof testing before service is a valuable method for ensuring the reliability of ceramic structures. Silicon carbide has been proposed as a very low activation first-wall and blanket structural material for fusion devices, where it would experience a high flux of fast neutrons. Strips of three types of silicon carbide were loaded in four-point bending to a stress sufficient to break about a third of the specimens. Groups of 16 survivors were irradiated to 2 × 10 26n/ m2 ( E>0.05 MeV) at 740°C and bend tested to failure. The strength distribution of chemically vapor-deposited silicon carbide (Texas Instruments) was virtually unchanged by irradiation. The mean strength of sintered silicon carbide (Carborundum Alpha) was reduced 34% by irradiation, while the Weibull modulus and the truncated strength distribution characteristic of proof-tested material were retained. Irradiation reduced the mean strength of reaction-bonded silicon carbide (Norton NC-430) by 58%, and the spread in strength values was increased. We conclude that for the chemically vapor-deposited and the sintered silicon carbide the benefits of proof testing to eliminate low strength material are retained after high neutron exposures.

  10. Accelerated Discovery of High-Refractive-Index Polymers Using First-Principles Modeling, Virtual High-Throughput Screening, and Data Mining

    NASA Astrophysics Data System (ADS)

    Afzal, Mohammad Atif Faiz; Cheng, Chong; Hachmann, Johannes

    Organic materials with refractive index (RI) values higher than 1.7 have attracted considerable interest in recent years due to the tremendous potential for their application in optical, optometric, and optoelectronic devices, and thus for shaping technological innovation in numerous related areas. Our work is concerned with creating predictive models for the optical properties of organic polymers, which will guide our experimentalist partners and allow them to target the most promising candidates. The RI model is developed based on a synergistic combination of first-principles electronic structure theory and machine learning techniques. The RI values predicted for common polymers using this model are in very good agreement with the experimental values. We also benchmark different DFT approximations along with various basis sets for their predictive performance in this model. We demonstrate that this combination of first-principles and data modeling is both successful and highly economical in determining the RI values of a wide range of organic polymers. To accelerate the development process, we cast this modeling approach into the high-throughput screening, materials informatics, and rational design framework that is developed in the group. This framework is a powerful tool and has shown to be highly promising for rapidly identifying polymer candidates with exceptional RI values as well as discovering design rules for advanced materials.

  11. Design of a high-bunch-charge 112-MHz superconducting RF photoemission electron source

    DOE PAGES

    Xin, T.; Brutus, J. C.; Belomestnykh, Sergey A.; ...

    2016-09-01

    High-bunch-charge photoemission electron-sources operating in a continuous wave (CW) mode are required for many advanced applications of particle accelerators, such as electron coolers for hadron beams, electron-ion colliders, and free-electron lasers (FELs). Superconducting RF (SRF) has several advantages over other electron-gun technologies in CW mode as it offers higher acceleration rate and potentially can generate higher bunch charges and average beam currents. A 112 MHz SRF electron photoinjector (gun) was developed at Brookhaven National Laboratory (BNL) to produce high-brightness and high-bunch-charge bunches for the Coherent electron Cooling Proof-of-Principle (CeC PoP) experiment. Lastly, the gun utilizes a quarter-wave resonator (QWR) geometrymore » for assuring beam dynamics, and uses high quantum efficiency (QE) multi-alkali photocathodes for generating electrons.« less

  12. Putting time into proof outlines

    NASA Technical Reports Server (NTRS)

    Schneider, Fred B.; Bloom, Bard; Marzullo, Keith

    1993-01-01

    A logic for reasoning about timing properties of concurrent programs is presented. The logic is based on Hoare-style proof outlines and can handle maximal parallelism as well as certain resource-constrained execution environments. The correctness proof for a mutual exclusion protocol that uses execution timings in a subtle way illustrates the logic in action. A soundness proof using structural operational semantics is outlined in the appendix.

  13. Statistical Mechanical Proof of the Second Law of Thermodynamics based on Volume Entropy

    NASA Astrophysics Data System (ADS)

    Campisi, Michele

    2007-10-01

    As pointed out in [M. Campisi. Stud. Hist. Phil. M. P. 36 (2005) 275-290] the volume entropy (that is the logarithm of the volume of phase space enclosed by the constant energy hyper-surface) provides a good mechanical analogue of thermodynamic entropy because it satisfies the heat theorem and it is an adiabatic invariant. This property explains the ``equal'' sign in Clausius principle (Sf>=Si) in a purely mechanical way and suggests that the volume entropy might explain the ``larger than'' sign (i.e. the Law of Entropy Increase) if non adiabatic transformations were considered. Based on the principles of quantum mechanics here we prove that, provided the initial equilibrium satisfy the natural condition of decreasing ordering of probabilities, the expectation value of the volume entropy cannot decrease for arbitrary transformations performed by some external sources of work on a insulated system. This can be regarded as a rigorous quantum mechanical proof of the Second Law.

  14. On the Analysis of Indirect Proofs: Contradiction and Contraposition

    ERIC Educational Resources Information Center

    Jourdan, Nicolas; Yevdokimov, Oleksiy

    2016-01-01

    The paper explores and clarifies the similarities and differences that exist between proof by contradiction and proof by contraposition. The paper also focuses on the concept of contradiction, and a general model for this method of proof is offered. The introduction of mathematical proof in the classroom remains a formidable challenge to students…

  15. A Device to Demonstrate the Principles of Photometry and Three Experiments for Its Use.

    ERIC Educational Resources Information Center

    Delumyea, R. Del

    1987-01-01

    Describes how to construct a simple photometer. Outlines experiments in which this device can be used to demonstrate basic electronic principles, the use of Beer's Law to determine the concentration of an analyte in solution, and the effect of molar absorptivity on the sensitivity of photometric procedures. (TW)

  16. Tested by Fire - How two recent Wildfires affected Accelerator Operations at LANL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spickermann, Thomas

    2012-08-01

    In a little more than a decade two large wild fires threatened Los Alamos and impacted accelerator operations at LANL. In 2000 the Cerro Grande Fire destroyed hundreds of homes, as well as structures and equipment at the DARHT facility. The DARHT accelerators were safe in a fire-proof building. In 2011 the Las Conchas Fire burned about 630 square kilometers (250 square miles) and came dangerously close to Los Alamos/LANL. LANSCE accelerator operations Lessons Learned during Las Conchas fire: (1) Develop a plan to efficiently shut down the accelerator on short notice; (2) Establish clear lines of communication in emergencymore » situations; and (3) Plan recovery and keep squirrels out.« less

  17. 16 CFR 614.1 - Appropriate proof of identity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Appropriate proof of identity. 614.1 Section... IDENTITY § 614.1 Appropriate proof of identity. (a) Consumer reporting agencies shall develop and implement reasonable requirements for what information consumers shall provide to constitute proof of identity for...

  18. 16 CFR 614.1 - Appropriate proof of identity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Appropriate proof of identity. 614.1 Section... IDENTITY § 614.1 Appropriate proof of identity. (a) Consumer reporting agencies shall develop and implement reasonable requirements for what information consumers shall provide to constitute proof of identity for...

  19. 16 CFR 614.1 - Appropriate proof of identity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Appropriate proof of identity. 614.1 Section... IDENTITY § 614.1 Appropriate proof of identity. (a) Consumer reporting agencies shall develop and implement reasonable requirements for what information consumers shall provide to constitute proof of identity for...

  20. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    NASA Technical Reports Server (NTRS)

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Millwater, H. R.

    1999-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semielliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT versus SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  1. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    NASA Technical Reports Server (NTRS)

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Orient, G. E.

    1996-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semi-elliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT vs. SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scarpelli, Andrea

    Nonlinear integrable optics applied to beam dynamics may mitigate multi-particle instabilities, but proof of principle experiments have never been carried out. The Integrable Optics Test Accelerator (IOTA) is an electron and proton storage ring currently being built at Fermilab, which addresses tests of nonlinear lattice elements in a real machine in addition to experiments on optical stochastic cooling and on the single-electron wave function. These experiments require an outstanding control over the lattice parameters, achievable with fast and precise beam monitoring systems. This work describes the steps for designing and building a beam monitor for IOTA based on synchrotron radiation,more » able to measure intensity, position and transverse cross-section beam.« less

  3. Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept.

    PubMed

    Mooij, Miriam G; van Duijn, Esther; Knibbe, Catherijne A J; Windhorst, Albert D; Hendrikse, N Harry; Vaes, Wouter H J; Spaans, Edwin; Fabriek, Babs O; Sandman, Hugo; Grossouw, Dimitri; Hanff, Lidwien M; Janssen, Paul J J M; Koch, Birgit C P; Tibboel, Dick; de Wildt, Saskia N

    2014-11-01

    Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain pharmacokinetic data in children with minimal burden and minimal risk. The use of a labeled oral microdose offers the added benefit to study intestinal and hepatic drug disposition in children already receiving an intravenous therapeutic drug dose for clinical reasons. The objective of this study was to present pilot data of an oral [(14)C]paracetamol [acetaminophen (AAP)] microdosing study as proof of concept to study developmental pharmacokinetics in children. In an open-label microdose pharmacokinetic pilot study, infants (0-6 years of age) received a single oral [(14)C]AAP microdose (3.3 ng/kg, 60 Bq/kg) in addition to intravenous therapeutic doses of AAP (15 mg/kg intravenous every 6 h). Blood samples were taken from an indwelling catheter. AAP blood concentrations were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and [(14)C]AAP and metabolites ([(14)C]AAP-Glu and [(14)C]AAP-4Sul) were measured by accelerator mass spectrometry. Ten infants (aged 0.1-83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [(14)C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (C max) [(14)C]AAP 1.68 (0.75-4.76) ng/L, [(14)C]AAP-Glu 0.88 (0.34-1.55) ng/L, and [(14)C]AAP-4Sul 0.81 (0.29-2.10) ng/L. Dose-normalized oral [(14)C]AAP C max approached median intravenous average concentrations (C av): 8.41 mg/L (3.75-23.78 mg/L) and 8.87 mg/L (3.45-12.9 mg/L), respectively. We demonstrate the feasibility of using a [(14)C]labeled microdose to study AAP pharmacokinetics, including metabolite disposition, in young children.

  4. Conceptual design of a pulsed-power accelerator optimized for megajoule-class 1-TPa dynamic-material-physics experiments

    DOE PAGES

    Stygar, William A.; Reisman, David B.; Stoltzfus, Brian S.; ...

    2016-07-07

    In this study, we have developed a conceptual design of a next-generation pulsed-power accelerator that is optmized for driving megajoule-class dynamic-material-physics experiments at pressures as high as 1 TPa. The design is based on an accelerator architecture that is founded on three concepts: single-stage electrical-pulse compression, impedance matching, and transit-time-isolated drive circuits. Since much of the accelerator is water insulated, we refer to this machine as Neptune. The prime power source of Neptune consists of 600 independent impedance-matched Marx generators. As much as 0.8 MJ and 20 MA can be delivered in a 300-ns pulse to a 16-mΩ physics load;more » hence Neptune is a megajoule-class 20-MA arbitrary waveform generator. Neptune will allow the international scientific community to conduct dynamic equation-of-state, phase-transition, mechanical-property, and other material-physics experiments with a wide variety of well-defined drive-pressure time histories. Because Neptune can deliver on the order of a megajoule to a load, such experiments can be conducted on centimeter-scale samples at terapascal pressures with time histories as long as 1 μs.« less

  5. Integrating Algebra and Proof in High School: Students' Work with Multiple Variables and a Single Parameter in a Proof Context

    ERIC Educational Resources Information Center

    Martinez, Mara V.; Castro Superfine, Alison

    2012-01-01

    In the United States, researchers argue that proof is largely concentrated in the domain of high school geometry, thus providing students a distorted image of what proof entails, which is at odds with the central role that proof plays in mathematics. Despite the centrality of proof, there is a lack of studies addressing how to integrate proof into…

  6. 38 CFR 10.28 - Proof of death evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Proof of death evidence... COMPENSATION Adjusted Compensation; General § 10.28 Proof of death evidence. Evidence required in establishing proof of death under the act, as amended, shall conform with the requirements set forth in the...

  7. 38 CFR 10.28 - Proof of death evidence.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Proof of death evidence... COMPENSATION Adjusted Compensation; General § 10.28 Proof of death evidence. Evidence required in establishing proof of death under the act, as amended, shall conform with the requirements set forth in the...

  8. 38 CFR 10.28 - Proof of death evidence.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Proof of death evidence... COMPENSATION Adjusted Compensation; General § 10.28 Proof of death evidence. Evidence required in establishing proof of death under the act, as amended, shall conform with the requirements set forth in the...

  9. 38 CFR 10.28 - Proof of death evidence.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Proof of death evidence... COMPENSATION Adjusted Compensation; General § 10.28 Proof of death evidence. Evidence required in establishing proof of death under the act, as amended, shall conform with the requirements set forth in the...

  10. 38 CFR 10.28 - Proof of death evidence.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Proof of death evidence... COMPENSATION Adjusted Compensation; General § 10.28 Proof of death evidence. Evidence required in establishing proof of death under the act, as amended, shall conform with the requirements set forth in the...

  11. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... years after first exposure, and proof of onset of a specified compensable disease more than five years... Specified Diseases Contracted After Exposure in an Affected Area (âDownwindersâ) § 79.25 Proof of onset of leukemia at least two years after first exposure, and proof of onset of a specified compensable disease...

  12. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... years after first exposure, and proof of onset of a specified compensable disease more than five years... Specified Diseases Contracted After Exposure in an Affected Area (âDownwindersâ) § 79.25 Proof of onset of leukemia at least two years after first exposure, and proof of onset of a specified compensable disease...

  13. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... years after first exposure, and proof of onset of a specified compensable disease more than five years... Specified Diseases Contracted After Exposure in an Affected Area (âDownwindersâ) § 79.25 Proof of onset of leukemia at least two years after first exposure, and proof of onset of a specified compensable disease...

  14. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... years after first exposure, and proof of onset of a specified compensable disease more than five years... Specified Diseases Contracted After Exposure in an Affected Area (âDownwindersâ) § 79.25 Proof of onset of leukemia at least two years after first exposure, and proof of onset of a specified compensable disease...

  15. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... years after first exposure, and proof of onset of a specified compensable disease more than five years... Specified Diseases Contracted After Exposure in an Affected Area (âDownwindersâ) § 79.25 Proof of onset of leukemia at least two years after first exposure, and proof of onset of a specified compensable disease...

  16. Gravitational acceleration as a cue for absolute size and distance?

    NASA Technical Reports Server (NTRS)

    Hecht, H.; Kaiser, M. K.; Banks, M. S.

    1996-01-01

    When an object's motion is influenced by gravity, as in the rise and fall of a thrown ball, the vertical component of acceleration is roughly constant at 9.8 m/sec2. In principle, an observer could use this information to estimate the absolute size and distance of the object (Saxberg, 1987a; Watson, Banks, von Hofsten, & Royden, 1992). In five experiments, we examined people's ability to utilize the size and distance information provided by gravitational acceleration. Observers viewed computer simulations of an object rising and falling on a trajectory aligned with the gravitational vector. The simulated objects were balls of different diameters presented across a wide range of simulated distances. Observers were asked to identify the ball that was presented and to estimate its distance. The results showed that observers were much more sensitive to average velocity than to the gravitational acceleration pattern. Likewise, verticality of the motion and visibility of the trajectory's apex had negligible effects on the accuracy of size and distance judgments.

  17. 12 CFR 1022.123 - Appropriate proof of identity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Appropriate proof of identity. 1022.123 Section...) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.123 Appropriate proof of identity... information consumers shall provide to constitute proof of identity for purposes of sections 605A, 605B, and...

  18. 12 CFR 1022.123 - Appropriate proof of identity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Appropriate proof of identity. 1022.123 Section...) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.123 Appropriate proof of identity... information consumers shall provide to constitute proof of identity for purposes of sections 605A, 605B, and...

  19. 12 CFR 1022.123 - Appropriate proof of identity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Appropriate proof of identity. 1022.123 Section...) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.123 Appropriate proof of identity... information consumers shall provide to constitute proof of identity for purposes of sections 605A, 605B, and...

  20. 28 CFR 79.34 - Proof of medical condition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Proof of medical condition. 79.34 Section... COMPENSATION ACT Eligibility Criteria for Claims by Onsite Participants § 79.34 Proof of medical condition. Proof of medical condition under this subpart will be made in the same manner and according to the same...

  1. 28 CFR 79.34 - Proof of medical condition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Proof of medical condition. 79.34 Section... COMPENSATION ACT Eligibility Criteria for Claims by Onsite Participants § 79.34 Proof of medical condition. Proof of medical condition under this subpart will be made in the same manner and according to the same...

  2. 39 CFR 501.5 - Burden of proof standard.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Burden of proof standard. 501.5 Section 501.5 Postal Service UNITED STATES POSTAL SERVICE POSTAGE PROGRAMS AUTHORIZATION TO MANUFACTURE AND DISTRIBUTE POSTAGE EVIDENCING SYSTEMS § 501.5 Burden of proof standard. The burden of proof is on the Postal Service...

  3. 28 CFR 79.34 - Proof of medical condition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of medical condition. 79.34 Section... COMPENSATION ACT Eligibility Criteria for Claims by Onsite Participants § 79.34 Proof of medical condition. Proof of medical condition under this subpart will be made in the same manner and according to the same...

  4. From statistical proofs of the Kochen-Specker theorem to noise-robust noncontextuality inequalities

    NASA Astrophysics Data System (ADS)

    Kunjwal, Ravi; Spekkens, Robert W.

    2018-05-01

    The Kochen-Specker theorem rules out models of quantum theory wherein projective measurements are assigned outcomes deterministically and independently of context. This notion of noncontextuality is not applicable to experimental measurements because these are never free of noise and thus never truly projective. For nonprojective measurements, therefore, one must drop the requirement that an outcome be assigned deterministically in the model and merely require that it be assigned a distribution over outcomes in a manner that is context-independent. By demanding context independence in the representation of preparations as well, one obtains a generalized principle of noncontextuality that also supports a quantum no-go theorem. Several recent works have shown how to derive inequalities on experimental data which, if violated, demonstrate the impossibility of finding a generalized-noncontextual model of this data. That is, these inequalities do not presume quantum theory and, in particular, they make sense without requiring an operational analog of the quantum notion of projectiveness. We here describe a technique for deriving such inequalities starting from arbitrary proofs of the Kochen-Specker theorem. It extends significantly previous techniques that worked only for logical proofs, which are based on sets of projective measurements that fail to admit of any deterministic noncontextual assignment, to the case of statistical proofs, which are based on sets of projective measurements that d o admit of some deterministic noncontextual assignments, but not enough to explain the quantum statistics.

  5. Experimental characterization of a coaxial plasma accelerator for a colliding plasma experiment

    NASA Astrophysics Data System (ADS)

    Wiechula, J.; Hock, C.; Iberler, M.; Manegold, T.; Schönlein, A.; Jacoby, J.

    2015-04-01

    We report experimental results of a single coaxial plasma accelerator in preparation for a colliding plasma experiment. The utilized device consisted of a coaxial pair of electrodes, accelerating the plasma due to J ×B forces. A pulse forming network, composed of three capacitors connected in parallel, with a total capacitance of 27 μF was set up. A thyratron allowed to switch the maximum applied voltage of 9 kV. Under these conditions, the pulsed currents reached peak values of about 103 kA. The measurements were performed in a small vacuum chamber with a neutral-gas prefill at gas pressures between 10 Pa and 14 000 Pa. A gas mixture of ArH2 with 2.8% H2 served as the discharge medium. H2 was chosen in order to observe the broadening of the Hβ emission line and thus estimate the electron density. The electron density for a single plasma accelerator reached peak values on the order of 1016 cm-3 . Electrical parameters, inter alia inductance and resistance, were determined for the LCR circuit during the plasma acceleration as well as in a short circuit case. Depending on the applied voltage, the inductance and resistance reached values ranging from 194 nH to 216 nH and 13 mΩ to 23 mΩ, respectively. Furthermore, the plasma velocity was measured using a fast CCD camera. Plasma velocities of 2 km/s up to 17 km/s were observed, the magnitude being highly correlated with gas pressure and applied voltage.

  6. Accelerating execution of the integrated TIGER series Monte Carlo radiation transport codes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, L.M.; Hochstedler, R.D.

    1997-02-01

    Execution of the integrated TIGER series (ITS) of coupled electron/photon Monte Carlo radiation transport codes has been accelerated by modifying the FORTRAN source code for more efficient computation. Each member code of ITS was benchmarked and profiled with a specific test case that directed the acceleration effort toward the most computationally intensive subroutines. Techniques for accelerating these subroutines included replacing linear search algorithms with binary versions, replacing the pseudo-random number generator, reducing program memory allocation, and proofing the input files for geometrical redundancies. All techniques produced identical or statistically similar results to the original code. Final benchmark timing of themore » accelerated code resulted in speed-up factors of 2.00 for TIGER (the one-dimensional slab geometry code), 1.74 for CYLTRAN (the two-dimensional cylindrical geometry code), and 1.90 for ACCEPT (the arbitrary three-dimensional geometry code).« less

  7. MEMS-based, RF-driven, compact accelerators

    NASA Astrophysics Data System (ADS)

    Persaud, A.; Seidl, P. A.; Ji, Q.; Breinyn, I.; Waldron, W. L.; Schenkel, T.; Vinayakumar, K. B.; Ni, D.; Lal, A.

    2017-10-01

    Shrinking existing accelerators in size can reduce their cost by orders of magnitude. Furthermore, by using radio frequency (RF) technology and accelerating ions in several stages, the applied voltages can be kept low paving the way to new ion beam applications. We make use of the concept of a Multiple Electrostatic Quadrupole Array Linear Accelerator (MEQALAC) and have previously shown the implementation of its basic components using printed circuit boards, thereby reducing the size of earlier MEQALACs by an order of magnitude. We now demonstrate the combined integration of these components to form a basic accelerator structure, including an initial beam-matching section. In this presentation, we will discuss the results from the integrated multi-beam ion accelerator and also ion acceleration using RF voltages generated on-board. Furthermore, we will show results from Micro-Electro-Mechanical Systems (MEMS) fabricated focusing wafers, which can shrink the dimension of the system to the sub-mm regime and lead to cheaper fabrication. Based on these proof-of-concept results we outline a scaling path to high beam power for applications in plasma heating in magnetized target fusion and in neutral beam injectors for future Tokamaks. This work was supported by the Office of Science of the US Department of Energy through the ARPA-e ALPHA program under contracts DE-AC02-05CH11231.

  8. A proof for substitution of endogenous iron (II) in lipoxygenase by exogenous Cu2+.

    PubMed

    Cai, Yan; Xu, Hong; Xia, Yongmei; Su, Yafen; Fang, Yun

    2010-10-01

    Soybean lipoxygenase (LOX) contains endogenous iron (II) at the active site, which is important for the enzyme activity. The activity of LOX can be accelerated by some exogenous metal ions including Cu2+. However, the mechanism of the activity improvement caused by exogenous metal ions remains unclear, not only for LOX but for most other metalloenzymes. Meanwhile, the possibility that exogenous metal ions can displace endogenous iron (II) is still in discussion for a lack of a direct and quantitative proof. In this paper, a quantitative proof of replacing iron (II) inside LOX by exogenous Cu2+ was provided, simply using UV-Vis spectrometry with two indicators p-carboxylantipyrylazo and 9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine. A 0.56 microM free iron (II) was observed in the bulk solution after incubating 9.45 microM Cu2+ with 16.10 microM LOX at 20 degrees C for 5 min, which is in coincidence with the decrement of Cu2+ in the bulk solution (0.53 microM), implying that iron (II) was replaced by Cu2+.

  9. Cognitive Testing in People at Increased Risk of Dementia Using a Smartphone App: The iVitality Proof-of-Principle Study

    PubMed Central

    Wijsman, Liselotte Willemijn; Cachucho, Ricardo; Hoevenaar-Blom, Marieke Peternella; Mooijaart, Simon Pieter; Richard, Edo

    2017-01-01

    Background Smartphone-assisted technologies potentially provide the opportunity for large-scale, long-term, repeated monitoring of cognitive functioning at home. Objective The aim of this proof-of-principle study was to evaluate the feasibility and validity of performing cognitive tests in people at increased risk of dementia using smartphone-based technology during a 6 months follow-up period. Methods We used the smartphone-based app iVitality to evaluate five cognitive tests based on conventional neuropsychological tests (Memory-Word, Trail Making, Stroop, Reaction Time, and Letter-N-Back) in healthy adults. Feasibility was tested by studying adherence of all participants to perform smartphone-based cognitive tests. Validity was studied by assessing the correlation between conventional neuropsychological tests and smartphone-based cognitive tests and by studying the effect of repeated testing. Results We included 151 participants (mean age in years=57.3, standard deviation=5.3). Mean adherence to assigned smartphone tests during 6 months was 60% (SD 24.7). There was moderate correlation between the firstly made smartphone-based test and the conventional test for the Stroop test and the Trail Making test with Spearman ρ=.3-.5 (P<.001). Correlation increased for both tests when comparing the conventional test with the mean score of all attempts a participant had made, with the highest correlation for Stroop panel 3 (ρ=.62, P<.001). Performance on the Stroop and the Trail Making tests improved over time suggesting a learning effect, but the scores on the Letter-N-back, the Memory-Word, and the Reaction Time tests remained stable. Conclusions Repeated smartphone-assisted cognitive testing is feasible with reasonable adherence and moderate relative validity for the Stroop and the Trail Making tests compared with conventional neuropsychological tests. Smartphone-based cognitive testing seems promising for large-scale data-collection in population studies. PMID

  10. Optimal Model-Based Fault Estimation and Correction for Particle Accelerators and Industrial Plants Using Combined Support Vector Machines and First Principles Models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sayyar-Rodsari, Bijan; Schweiger, Carl; /SLAC /Pavilion Technologies, Inc., Austin, TX

    2010-08-25

    .e. the parameters of the beam lifetime model) are physically meaningful. (3) Numerical Efficiency of the Training - We investigated the numerical efficiency of the SVM training. More specifically, for the primal formulation of the training, we have developed a problem formulation that avoids the linear increase in the number of the constraints as a function of the number of data points. (4) Flexibility of Software Architecture - The software framework for the training of the support vector machines was designed to enable experimentation with different solvers. We experimented with two commonly used nonlinear solvers for our simulations. The primary application of interest for this project has been the sustained optimal operation of particle accelerators at the Stanford Linear Accelerator Center (SLAC). Particle storage rings are used for a variety of applications ranging from 'colliding beam' systems for high-energy physics research to highly collimated x-ray generators for synchrotron radiation science. Linear accelerators are also used for collider research such as International Linear Collider (ILC), as well as for free electron lasers, such as the Linear Coherent Light Source (LCLS) at SLAC. One common theme in the operation of storage rings and linear accelerators is the need to precisely control the particle beams over long periods of time with minimum beam loss and stable, yet challenging, beam parameters. We strongly believe that beyond applications in particle accelerators, the high fidelity and cost benefits of a combined model-based fault estimation/correction system will attract customers from a wide variety of commercial and scientific industries. Even though the acquisition of Pavilion Technologies, Inc. by Rockwell Automation Inc. in 2007 has altered the small business status of the Pavilion and it no longer qualifies for a Phase II funding, our findings in the course of the Phase I research have convinced us that further research will render a workable

  11. An integrated experimental and computational approach to material selection for sound proof thermally insulted enclosure of a power generation system

    NASA Astrophysics Data System (ADS)

    Waheed, R.; Tarar, W.; Saeed, H. A.

    2016-08-01

    Sound proof canopies for diesel power generators are fabricated with a layer of sound absorbing material applied to all the inner walls. The physical properties of the majority of commercially available sound proofing materials reveal that a material with high sound absorption coefficient has very low thermal conductivity. Consequently a good sound absorbing material is also a good heat insulator. In this research it has been found through various experiments that ordinary sound proofing materials tend to rise the inside temperature of sound proof enclosure in certain turbo engines by capturing the heat produced by engine and not allowing it to be transferred to atmosphere. The same phenomenon is studied by creating a finite element model of the sound proof enclosure and performing a steady state and transient thermal analysis. The prospects of using aluminium foam as sound proofing material has been studied and it is found that inside temperature of sound proof enclosure can be cut down to safe working temperature of power generator engine without compromise on sound proofing.

  12. Using a national archive of patient experience narratives to promote local patient-centered quality improvement: an ethnographic process evaluation of 'accelerated' experience-based co-design.

    PubMed

    Locock, Louise; Robert, Glenn; Boaz, Annette; Vougioukalou, Sonia; Shuldham, Caroline; Fielden, Jonathan; Ziebland, Sue; Gager, Melanie; Tollyfield, Ruth; Pearcey, John

    2014-10-01

    To evaluate an accelerated form of experience-based co-design (EBCD), a type of participatory action research in which patients and staff work together to improve quality; to observe how acceleration affected the process and outcomes of the intervention. An ethnographic process evaluation of an adapted form of EBCD was conducted, including observations, interviews, questionnaires and documentary analysis. Whilst retaining all components of EBCD, the adapted approach replaced local patient interviews with secondary analysis of a national archive of patient experience narratives to create national trigger films; shortened the timeframe; and employed local improvement facilitators. It was tested in intensive care and lung cancer in two English National Health Service (NHS) hospitals. A total of 96 clinical staff (primarily nursing and medical), and 63 patients and family members participated in co-design activities. The accelerated approach proved acceptable to staff and patients; using films of national rather than local narratives did not adversely affect local NHS staff engagement, and may have made the process less threatening or challenging. Local patients felt the national films generally reflected important themes although a minority felt they were more negative than their own experience. However, they served their purpose of 'triggering' discussion between patients and staff, and the resulting 48 co-design (improvement) activities across the four pathways were similar to those in EBCD, but achieved more quickly and at lower cost. Accelerated EBCD offers a rigorous and relatively cost-effective patient-centered quality improvement approach. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  13. Significant issues in proof testing: A critical appraisal

    NASA Technical Reports Server (NTRS)

    Chell, G. G.; Mcclung, R. C.; Russell, D. A.; Chang, K. J.; Donnelly, B.

    1994-01-01

    Issues which impact on the interpretation and quantification of proof test benefits are reviewed. The importance of each issue in contributing to the extra quality assurance conferred by proof testing components is discussed, particularly with respect to the application of advanced fracture mechanics concepts to enhance the flaw screening capability of a proof test analysis. Items covered include the role in proof testing of elastic-plastic fracture mechanics, ductile instability analysis, deterministic versus probabilistic analysis, single versus multiple cycle proof testing, and non-destructive examination (NDE). The effects of proof testing on subsequent service life are reviewed, particularly with regard to stress redistribution and changes in fracture behavior resulting from the overload. The importance of proof test conditions are also addressed, covering aspects related to test temperature, simulation of service environments, test media and the application of real-time NDE. The role of each issue in a proof test methodology is assessed with respect to its ability to: promote proof test practice to a state-of-the-art; aid optimization of proof test design; and increase awareness and understanding of outstanding issues.

  14. Computerized proof techniques for undergraduates

    NASA Astrophysics Data System (ADS)

    Smith, Christopher J.; Tefera, Akalu; Zeleke, Aklilu

    2012-12-01

    The use of computer algebra systems such as Maple and Mathematica is becoming increasingly important and widespread in mathematics learning, teaching and research. In this article, we present computerized proof techniques of Gosper, Wilf-Zeilberger and Zeilberger that can be used for enhancing the teaching and learning of topics in discrete mathematics. We demonstrate by examples how one can use these computerized proof techniques to raise students' interests in the discovery and proof of mathematical identities and enhance their problem-solving skills.

  15. Accelerating Translational Research through Open Science: The Neuro Experiment.

    PubMed

    Gold, E Richard

    2016-12-01

    Translational research is often afflicted by a fundamental problem: a limited understanding of disease mechanisms prevents effective targeting of new treatments. Seeking to accelerate research advances and reimagine its role in the community, the Montreal Neurological Institute (Neuro) announced in the spring of 2016 that it is launching a five-year experiment during which it will adopt Open Science-open data, open materials, and no patenting-across the institution. The experiment seeks to examine two hypotheses. The first is whether the Neuro's Open Science initiative will attract new private partners. The second hypothesis is that the Neuro's institution-based approach will draw companies to the Montreal region, where the Neuro is based, leading to the creation of a local knowledge hub. This article explores why these hypotheses are likely to be true and describes the Neuro's approach to exploring them.

  16. Gravity and decoherence: the double slit experiment revisited

    NASA Astrophysics Data System (ADS)

    Samuel, Joseph

    2018-02-01

    The double slit experiment is iconic and widely used in classrooms to demonstrate the fundamental mystery of quantum physics. The puzzling feature is that the probability of an electron arriving at the detector when both slits are open is not the sum of the probabilities when the slits are open separately. The superposition principle of quantum mechanics tells us to add amplitudes rather than probabilities and this results in interference. This experiment defies our classical intuition that the probabilities of exclusive events add. In understanding the emergence of the classical world from the quantum one, there have been suggestions by Feynman, Diosi and Penrose that gravity is responsible for suppressing interference. This idea has been pursued in many different forms ever since, predominantly within Newtonian approaches to gravity. In this paper, we propose and theoretically analyse two ‘gedanken’ or thought experiments which lend strong support to the idea that gravity is responsible for decoherence. The first makes the point that thermal radiation can suppress interference. The second shows that in an accelerating frame, Unruh radiation does the same. Invoking the Einstein equivalence principle to relate acceleration to gravity, we support the view that gravity is responsible for decoherence.

  17. Principles of Safety Pharmacology

    PubMed Central

    Pugsley, M K; Authier, S; Curtis, M J

    2008-01-01

    Safety Pharmacology is a rapidly developing discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment. The aim of Safety Pharmacology is to characterize the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects using continuously evolving methodology. Unlike toxicology, Safety Pharmacology includes within its remit a regulatory requirement to predict the risk of rare lethal events. This gives Safety Pharmacology its unique character. The key issues for Safety Pharmacology are detection of an adverse effect liability, projection of the data into safety margin calculation and finally clinical safety monitoring. This article sets out to explain the drivers for Safety Pharmacology so that the wider pharmacology community is better placed to understand the discipline. It concludes with a summary of principles that may help inform future resolution of unmet needs (especially establishing model validation for accurate risk assessment). Subsequent articles in this issue of the journal address specific aspects of Safety Pharmacology to explore the issues of model choice, the burden of proof and to highlight areas of intensive activity (such as testing for drug-induced rare event liability, and the challenge of testing the safety of so-called biologics (antibodies, gene therapy and so on.). PMID:18604233

  18. Design of a Laboratory Hall Thruster with Magnetically Shielded Channel Walls, Phase III: Comparison of Theory with Experiment

    NASA Technical Reports Server (NTRS)

    Mikellides, Ioannis G.; Katz, Ira; Hofer, Richard R.; Goebel, Dan M.

    2012-01-01

    A proof-of-principle effort to demonstrate a technique by which erosion of the acceleration channel in Hall thrusters of the magnetic-layer type can be eliminated has been completed. The first principles of the technique, now known as "magnetic shielding," were derived based on the findings of numerical simulations in 2-D axisymmetric geometry. The simulations, in turn, guided the modification of an existing 6-kW laboratory Hall thruster. This magnetically shielded (MS) thruster was then built and tested. Because neither theory nor experiment alone can validate fully the first principles of the technique, the objective of the 2-yr effort was twofold: (1) to demonstrate in the laboratory that the erosion rates can be reduced by >order of magnitude, and (2) to demonstrate that the near-wall plasma properties can be altered according to the theoretical predictions. This paper concludes the demonstration of magnetic shielding by reporting on a wide range of comparisons between results from numerical simulations and laboratory diagnostics. Collectively, we find that the comparisons validate the theory. Near the walls of the MS thruster, theory and experiment agree: (1) the plasma potential has been sustained at values near the discharge voltage, and (2) the electron temperature has been lowered by at least 2.5-3 times compared to the unshielded (US) thruster. Also, based on carbon deposition measurements, the erosion rates at the inner and outer walls of the MS thruster are found to be lower by at least 2300 and 1875 times, respectively. Erosion was so low along these walls that the rates were below the resolution of the profilometer. Using a sputtering yield model with an energy threshold of 25 V, the simulations predict a reduction of 600 at the MS inner wall. At the outer wall ion energies are computed to be below 25 V, for which case we set the erosion to zero in the simulations. When a 50-V threshold is used the computed ion energies are below the threshold at both

  19. A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine.

    PubMed

    van Vliet, Erwin; Morath, Siegfried; Eskes, Chantra; Linge, Jens; Rappsilber, Juri; Honegger, Paul; Hartung, Thomas; Coecke, Sandra

    2008-01-01

    There is a need for more efficient methods giving insight into the complex mechanisms of neurotoxicity. Testing strategies including in vitro methods have been proposed to comply with this requirement. With the present study we aimed to develop a novel in vitro approach which mimics in vivo complexity, detects neurotoxicity comprehensively, and provides mechanistic insight. For this purpose we combined rat primary re-aggregating brain cell cultures with a mass spectrometry (MS)-based metabolomics approach. For the proof of principle we treated developing re-aggregating brain cell cultures for 48 h with the neurotoxicant methyl mercury chloride (0.1-100 microM) and the brain stimulant caffeine (1-100 microM) and acquired cellular metabolic profiles. To detect toxicant-induced metabolic alterations the profiles were analysed using commercial software which revealed patterns in the multi-parametric dataset by principal component analyses (PCA), and recognised the most significantly altered metabolites. PCA revealed concentration-dependent cluster formations for methyl mercury chloride (0.1-1 microM), and treatment-dependent cluster formations for caffeine (1-100 microM) at sub-cytotoxic concentrations. Four relevant metabolites responsible for the concentration-dependent alterations following methyl mercury chloride treatment could be identified using MS-MS fragmentation analysis. These were gamma-aminobutyric acid, choline, glutamine, creatine and spermine. Their respective mass ion intensities demonstrated metabolic alterations in line with the literature and suggest that the metabolites could be biomarkers for mechanisms of neurotoxicity or neuroprotection. In addition, we evaluated whether the approach could identify neurotoxic potential by testing eight compounds which have target organ toxicity in the liver, kidney or brain at sub-cytotoxic concentrations. PCA revealed cluster formations largely dependent on target organ toxicity indicating possible potential

  20. Mathematical Proof. Description of Teacher Inservice Education Materials.

    ERIC Educational Resources Information Center

    National Education Association, Washington, DC. Project on Utilization of Inservice Education R & D Outcomes.

    The learning module described here is designed to help teachers plan and present a lesson on mathematical proof to pupils. The main topics covered are structure, hypothesis and conclusion, analysis, contrapositive, proof by contradiction, part proof worksheet, and conclusion and posttest. This descriptive report provides information on the…

  1. Studies of orbital Eoetvoes experiments

    NASA Technical Reports Server (NTRS)

    Chapman, P. K.

    1977-01-01

    A direct force-balance technique was analyzed for carrying out the Eoetvoes experiment in space, which is intended to give sufficient sensitivity to allow investigation of the gravitational interactions of energy stored in the weak interaction. The heart of experiment is an exceedingly sensitive dual accelerometer, containing two proof masses constructed of the materials whose Eoetvoes ratio is to be compared. For use in development of the accelerometer, a magnetic microbalance is proposed in which the weight of the proof mass is supported by magnetic forces which vary very slowly with the proof mass position. It is shown that at least two different mechanizations of the magnetic suspension may be feasible.

  2. 18 CFR 4.6 - Burden of proof.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.6 Burden of proof. The burden of proof to sustain each item of claimed cost shall be upon the licensee and only such items as...

  3. 18 CFR 4.6 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.6 Burden of proof. The burden of proof to sustain each item of claimed cost shall be upon the licensee and only such items as...

  4. 18 CFR 4.6 - Burden of proof.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.6 Burden of proof. The burden of proof to sustain each item of claimed cost shall be upon the licensee and only such items as...

  5. 18 CFR 4.6 - Burden of proof.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.6 Burden of proof. The burden of proof to sustain each item of claimed cost shall be upon the licensee and only such items as...

  6. 18 CFR 4.6 - Burden of proof.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.6 Burden of proof. The burden of proof to sustain each item of claimed cost shall be upon the licensee and only such items as...

  7. Principles for timing at spallation neutron sources based on developments at LANSCE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, R. O.; Merl, R. B.; Rose, C. R.

    2001-01-01

    Due to AC-power-grid frequency fluctuations, the designers for accelerator-based spallation-neutron facilities have worked to optimize the conflicting demands of accelerator and neutron chopper performance. For the first time, we are able to quantitatively access the tradeoffs between these two constraints and design or upgrade a facility to optimize total system performance using powerful new simulation techniques. We have modeled timing systems that integrate chopper controllers and chopper hardware and built new systems. Thus, at LANSCE, we now operate multiple chopper systems and the accelerator as simple slaves to a single master-timing-reference generator. Based on this experience we recommend that spallationmore » neutron sources adhere to three principles. First, timing for pulsed sources should be planned starting with extraction at a fixed phase and working backwards toward the leading edge of the beam pulse. Second, accelerator triggers and storage ring extraction commands from neutron choppers offer only marginal benefits to accelerator-based spallation sources. Third, the storage-ring RF should be phase synchronized with neutron choppers to provide extraction without the one orbit timing uncertainty.« less

  8. 14 CFR 13.224 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.224 Burden of proof... otherwise provided by statute or rule, the proponent of a motion, request, or order has the burden of proof...

  9. Hawking radiation, Unruh radiation, and the equivalence principle.

    PubMed

    Singleton, Douglas; Wilburn, Steve

    2011-08-19

    We compare the response function of an Unruh-DeWitt detector for different space-times and different vacua and show that there is a detailed violation of the equivalence principle. In particular comparing the response of an accelerating detector to a detector at rest in a Schwarzschild space-time we find that both detectors register thermal radiation, but for a given, equivalent acceleration the fixed detector in the Schwarzschild space-time measures a higher temperature. This allows one to locally distinguish the two cases. As one approaches the horizon the two temperatures have the same limit so that the equivalence principle is restored at the horizon. © 2011 American Physical Society

  10. Experience-dependent enhancement of pitch-specific responses in the auditory cortex is limited to acceleration rates in normal voice range

    PubMed Central

    Krishnan, Ananthanarayan; Gandour, Jackson T.; Suresh, Chandan H.

    2015-01-01

    The aim of this study is to determine how pitch acceleration rates within and outside the normal pitch range may influence latency and amplitude of cortical pitch-specific responses (CPR) as a function of language experience (Chinese, English). Responses were elicited from a set of four pitch stimuli chosen to represent a range of acceleration rates (two each inside and outside the normal voice range) imposed on the high rising Mandarin Tone 2. Pitch-relevant neural activity, as reflected in the latency and amplitude of scalp-recorded CPR components, varied depending on language-experience and pitch acceleration of dynamic, time-varying pitch contours. Peak latencies of CPR components were shorter in the Chinese than the English group across stimuli. Chinese participants showed greater amplitude than English for CPR components at both frontocentral and temporal electrode sites in response to pitch contours with acceleration rates inside the normal voice pitch range as compared to pitch contours with acceleration rates that exceed the normal range. As indexed by CPR amplitude at the temporal sites, a rightward asymmetry was observed for the Chinese group only. Only over the right temporal site was amplitude greater in the Chinese group relative to the English. These findings may suggest that the neural mechanism(s) underlying processing of pitch in the right auditory cortex reflect experience-dependent modulation of sensitivity to acceleration in just those rising pitch contours that fall within the bounds of one’s native language. More broadly, enhancement of native pitch stimuli and stronger rightward asymmetry of CPR components in the Chinese group is consistent with the notion that long-term experience shapes adaptive, distributed hierarchical pitch processing in the auditory cortex, and reflects an interaction with higher-order, extrasensory processes beyond the sensory memory trace. PMID:26166727

  11. Using Sudoku to Introduce Proof Techniques

    ERIC Educational Resources Information Center

    Snyder, Brian A.

    2010-01-01

    In this article we show how the Sudoku puzzle and the three simple rules determining its solution can be used as an introduction to proof-based mathematics. In the completion of the puzzle, students can construct multi-step solutions that involve sequencing of steps, use methods such as backtracking and proof by cases, and proof by contradiction…

  12. Transport calculations and accelerator experiments needed for radiation risk assessment in space.

    PubMed

    Sihver, Lembit

    2008-01-01

    The major uncertainties on space radiation risk estimates in humans are associated to the poor knowledge of the biological effects of low and high LET radiation, with a smaller contribution coming from the characterization of space radiation field and its primary interactions with the shielding and the human body. However, to decrease the uncertainties on the biological effects and increase the accuracy of the risk coefficients for charged particles radiation, the initial charged-particle spectra from the Galactic Cosmic Rays (GCRs) and the Solar Particle Events (SPEs), and the radiation transport through the shielding material of the space vehicle and the human body, must be better estimated Since it is practically impossible to measure all primary and secondary particles from all possible position-projectile-target-energy combinations needed for a correct risk assessment in space, accurate particle and heavy ion transport codes must be used. These codes are also needed when estimating the risk for radiation induced failures in advanced microelectronics, such as single-event effects, etc., and the efficiency of different shielding materials. It is therefore important that the models and transport codes will be carefully benchmarked and validated to make sure they fulfill preset accuracy criteria, e.g. to be able to predict particle fluence, dose and energy distributions within a certain accuracy. When validating the accuracy of the transport codes, both space and ground based accelerator experiments are needed The efficiency of passive shielding and protection of electronic devices should also be tested in accelerator experiments and compared to simulations using different transport codes. In this paper different multipurpose particle and heavy ion transport codes will be presented, different concepts of shielding and protection discussed, as well as future accelerator experiments needed for testing and validating codes and shielding materials.

  13. [Bioethics of principles].

    PubMed

    Pérez-Soba Díez del Corral, Juan José

    2008-01-01

    Bioethics emerges about the tecnological problems of acting in human life. Emerges also the problem of the moral limits determination, because they seem exterior of this practice. The Bioethics of Principles, take his rationality of the teleological thinking, and the autonomism. These divergence manifest the epistemological fragility and the great difficulty of hmoralñ thinking. This is evident in the determination of autonomy's principle, it has not the ethical content of Kant's propose. We need a new ethic rationality with a new refelxion of new Principles whose emerges of the basic ethic experiences.

  14. Collaborative engagement experiment

    NASA Astrophysics Data System (ADS)

    Mullens, Katherine; Troyer, Bradley; Wade, Robert; Skibba, Brian; Dunn, Michael

    2006-05-01

    Unmanned ground and air systems operating in collaboration have the potential to provide future Joint Forces a significant capability for operations in complex terrain. Collaborative Engagement Experiment (CEE) is a consolidation of separate Air Force, Army and Navy collaborative efforts within the Joint Robotics Program (JRP) to provide a picture of the future of unmanned warfare. The Air Force Research Laboratory (AFRL), Material and Manufacturing Directorate, Aerospace Expeditionary Force Division, Force Protection Branch (AFRL/MLQF), The Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) Joint Technology Center (JTC)/Systems Integration Laboratory (SIL), and the Space and Naval Warfare Systems Center - San Diego (SSC San Diego) are conducting technical research and proof of principle experiments for an envisioned operational concept for extended range, three dimensional, collaborative operations between unmanned systems, with enhanced situational awareness for lethal operations in complex terrain. This paper describes the work by these organizations to date and outlines some of the plans for future work.

  15. A study of the feasibility of conducting the ELISE and EXL experiments at the ITEP accelerator complex

    NASA Astrophysics Data System (ADS)

    Bolshakov, A. E.; Golubev, A. A.; Zenkevich, P. R.; Kats, M. M.; Kolomiets, A. A.

    2014-09-01

    We report the results of a study into the feasibility of conducting the ELISE and EXL experiments on collisions of nuclei of radioactive fragments with electrons at the Institute for Theoretical and Experimental Physics (ITEP). A scheme for uranium ion acceleration in the ITEP accelerator complex is chosen, and it is shown that uranium ions may be accelerated with an intensity of ˜1 × 1011 ions/s as soon as the complex is modified and a new injector is constructed. The basic parameters of the modified complex are given, and a layout diagram indicating the positions of the target that serves to produce radioactive fragments, the separator, and the storage rings (CR, RESR, NESR, and ER) at the ITEP site is presented.

  16. Application of Fracture Mechanics to Specify the Proof Load Factor for Clamp Band Systems of Launch Vehicles

    NASA Astrophysics Data System (ADS)

    Singaravelu, J.; Sundaresan, S.; Nageswara Rao, B.

    2013-04-01

    This article presents a methodology for evaluation of the proof load factor (PLF) for clamp band system (CBS) made of M250 Maraging steel following fracture mechanics principles.CBS is most widely used as a structural element and as a separation system. Using Taguchi's design of experiments and the response surface method (RSM) the compact tension specimens were tested to establish an empirical relation for the failure load ( P max) in terms of the ultimate strength, width, thickness, and initial crack length. The test results of P max closely matched with the developed RSM empirical relation. Crack growth rates of the maraging steel in different environments were examined. Fracture strength (σf) of center surface cracks and through-crack tension specimens are evaluated utilizing the fracture toughness ( K IC). Stress induced in merman band at flight loading conditions is evaluated to estimate the higher load factor and PLF. Statistical safety factor and reliability assessments were made for the specified flaw sizes useful in the development of fracture control plan for CBS of launch vehicles.

  17. Measurement of the quality factor of a new low-frequency differential accelerometer for testing the equivalence principle.

    PubMed

    Iafolla, V; Lefevre, C; Fiorenza, E; Santoli, F; Nozzoli, S; Magnafico, C; Lucente, M; Lucchesi, D; Peron, R; Shapiro, I I; Glashow, S; Lorenzini, E C

    2014-01-01

    A cryogenic differential accelerometer has been developed to test the weak equivalence principle to a few parts in 10(15) within the framework of the general relativity accuracy test in an Einstein elevator experiment. The prototype sensor was designed to identify, address, and solve the major issues associated with various aspects of the experiment. This paper illustrates the measurements conducted on this prototype sensor to attain a high quality factor (Q ∼ 10(5)) at low frequencies (<20 Hz). Such a value is necessary for reducing the Brownian noise to match the target acceleration noise of 10(-14) g/√Hz, hence providing the desired experimental accuracy.

  18. One Problem, Nine Student-Produced Proofs

    ERIC Educational Resources Information Center

    Birky, Geoffrey; Campbell, Connie M.; Raman, Manya; Sandefur, James; Somers, Kay

    2011-01-01

    This paper tells the story of what happened when students in the authors' sophomore-level introduction-to-proof classes were given a theorem to prove with no expectation about what proof method to use. The paper discusses the nine different student-produced proofs of the statement: If "n" is an integer such that "n" is greater than or equal to 3,…

  19. Motivation for proposed experimentation in the realm of accelerated E. M. systems: A preliminary design for an experiment

    NASA Technical Reports Server (NTRS)

    Post, E. J.

    1970-01-01

    An experiment, designed to determine the difference between fields-magnetic and electric-surrounding a uniformly moving charge as contrasted with the fields surrounding an accelerated charge, is presented. A thought experiment is presented to illustrate the process.

  20. Investigating the Teaching and Learning of Proof: First Year Results.

    ERIC Educational Resources Information Center

    Martin, Tami S.; McCrone, Sharon Soucy

    Although proof and reasoning are seen as fundamental components of learning mathematics, research shows that many students continue to struggle with geometric proofs. In order to relate pedagogical methods to students' understanding of geometric proof, this 3-year project focuses on 2 components of student understanding of proof, namely, students'…

  1. 31 CFR 515.543 - Proof of origin.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of goods of Cuban origin are generally not issued unless the applicant submits satisfactory... constitute satisfactory proof varies depending upon the facts of the particular case, it is not possible to... satisfactory proof of origin. Independent corroborating documentary evidence, such as insurance documents...

  2. Collisionless Shocks and Particle Acceleration.

    NASA Astrophysics Data System (ADS)

    Malkov, M.

    2016-12-01

    Collisionless shocks emerged in the 50s and 60s of the last century as an important branch of plasma physics and have remained ever since. New applications pose new challenges to our understanding of collisionless shock mechanisms. Particle acceleration in astrophysical settings, primarily studied concerning the putative origin of cosmic rays (CR) in supernova remnant (SNR) shocks, stands out with the collisionless shock mechanism being the key. Among recent laboratory applications, a laser-based tabletop proton accelerator is an affordable compact alternative to big synchrotron accelerators. The much-anticipated proof of cosmic ray (CR) acceleration in supernova remnants is hindered by our limited understanding of collisionless shock mechanisms. Over the last decade, dramatically improved observations were puzzling the theorists with unexpected discoveries. The difference between the helium/carbon and proton CR rigidity (momentum to charge ratio) spectra, seemingly inconsistent with the acceleration and propagation theories, and the perplexing positron excess in the 10-300 GeV range are just two recent examples. The latter is now also actively discussed in the particle physics and CR communities as a possible signature of decay or annihilation of hypothetical dark matter particles. By considering an initial (injection) phase of a diffusive shock acceleration mechanism, including particle reflection off the shock front - where an elemental similarity of particle dynamics does not apply - I will discuss recent suggestions of how to address the new data from the collisionless shock perspective. The backreaction of accelerated particles on the shock structure, its environment, and visibility across the electromagnetic spectrum from radio to gamma rays is another key aspect of collisionless shock that will be discussed.

  3. Mathematically Gifted High School Students' Approaches to Developing Visual Proofs (VP) and Preliminary Ideas about VP

    ERIC Educational Resources Information Center

    Ugurel, Isikhan; Morali, H. Sevgi; Karahan, Ozge; Boz, Burcak

    2016-01-01

    The purpose of this study is to describe the procedure and examples of visual proofs (VP-or proof without words) developed by gifted mathematics secondary school students after their experiences. The participants of this study are three male 9th grade students enrolled in a private science high school. In the first stage of the research a briefing…

  4. Acceleration ground test program to verify GAS payload No. 559 structure/support avionics and experiment structural integrity

    NASA Technical Reports Server (NTRS)

    Cassanto, John M.; Cassanto, Valerie A.

    1988-01-01

    Acceleration ground tests were conducted on the Get Away Special (GAS) payload 559 to verify the structural integrity of the structure/support avionics and two of the planned three flight experiments. The ITA (Integrated Test Area) Standardized Experiment Module (ISEM) structure was modified to accommodate the experiments for payload 559. The ISEM avionics consisted of a heavy duty sliver zinc power supply, three orthogonal-mounted low range microgravity accelerometers, a tri-axis high range accelerometer, a solid state recorder/programmer sequencer, and pressure and temperature sensors. The tests were conducted using the Gravitational Plant Physiology Laboratory Centrifuge of the University City Science Center in Philadelphia, PA. The launch-powered flight steady state acceleration profile of the shuttle was simulated from lift-off through jettison of the External Tank (3.0 g's). Additional tests were conducted at twice the nominal powered flight acceleration levels (6 g's) and an over-test condition of four times the powered flight loads to 12.6 g's. The present test program has demonstrated the value of conducting ground tests to verify GAS payload experiment integrity and operation before flying on the shuttle.

  5. Deriving Safety Cases from Automatically Constructed Proofs

    NASA Technical Reports Server (NTRS)

    Basir, Nurlida; Denney, Ewen; Fischer, Bernd

    2009-01-01

    Formal proofs provide detailed justification for the validity of claims and are widely used in formal software development methods. However, they are often complex and difficult to understand, because the formalism in which they are constructed and encoded is usually machine-oriented, and they may also be based on assumptions that are not justified. This causes concerns about the trustworthiness of using formal proofs as arguments in safety-critical applications. Here, we present an approach to develop safety cases that correspond to formal proofs found by automated theorem provers and reveal the underlying argumentation structure and top-level assumptions. We concentrate on natural deduction style proofs, which are closer to human reasoning than resolution proofs, and show how to construct the safety cases by covering the natural deduction proof tree with corresponding safety case fragments. We also abstract away logical book-keeping steps, which reduces the size of the constructed safety cases. We show how the approach can be applied to the proofs found by the Muscadet prover.

  6. Development of a He- and He0 beam source for alpha particle measurement in a burning plasma.

    PubMed

    Tanaka, N; Sasao, M; Terai, K; Okamoto, A; Kitajima, S; Yamaoka, H; Wada, M

    2012-02-01

    Proof of principle experiments of neutral helium beam production for alpha particle diagnostics was carried out on a test stand. Negative helium ions were produced in the Li charge exchange cell, in which stable and long time operation was possible. He(-) beam was accelerated to 157 keV. Finally, He(0) beam was successfully produced after the flight in the drift-tube through the auto-electron-detachment process from He(-) to He(0). A neutral beam detector using a pyroelectric device was also developed to measure He(0) beam intensity. The metastable component in the neutral helium beam was found to be less than 2%.

  7. 28 CFR 79.13 - Proof of physical presence for the requisite period and proof of participation onsite during a...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... participated onsite in the atmospheric detonation of a nuclear device. ... requisite period and proof of participation onsite during a period of atmospheric nuclear testing. 79.13... presence for the requisite period and proof of participation onsite during a period of atmospheric nuclear...

  8. 28 CFR 79.13 - Proof of physical presence for the requisite period and proof of participation onsite during a...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requisite period and proof of participation onsite during a period of atmospheric nuclear testing. 79.13... presence for the requisite period and proof of participation onsite during a period of atmospheric nuclear... participated onsite in the atmospheric detonation of a nuclear device. ...

  9. 28 CFR 79.13 - Proof of physical presence for the requisite period and proof of participation onsite during a...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requisite period and proof of participation onsite during a period of atmospheric nuclear testing. 79.13... presence for the requisite period and proof of participation onsite during a period of atmospheric nuclear... participated onsite in the atmospheric detonation of a nuclear device. ...

  10. 28 CFR 79.13 - Proof of physical presence for the requisite period and proof of participation onsite during a...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requisite period and proof of participation onsite during a period of atmospheric nuclear testing. 79.13... presence for the requisite period and proof of participation onsite during a period of atmospheric nuclear... participated onsite in the atmospheric detonation of a nuclear device. ...

  11. 28 CFR 79.13 - Proof of physical presence for the requisite period and proof of participation onsite during a...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requisite period and proof of participation onsite during a period of atmospheric nuclear testing. 79.13... presence for the requisite period and proof of participation onsite during a period of atmospheric nuclear... participated onsite in the atmospheric detonation of a nuclear device. ...

  12. The Great Emch Closure Theorem and a combinatorial proof of Poncelet's Theorem

    NASA Astrophysics Data System (ADS)

    Avksentyev, E. A.

    2015-11-01

    The relations between the classical closure theorems (Poncelet's, Steiner's, Emch's, and the zigzag theorems) and some of their generalizations are discussed. It is known that Emch's Theorem is the most general of these, while the others follow as special cases. A generalization of Emch's Theorem to pencils of circles is proved, which (by analogy with the Great Poncelet Theorem) can be called the Great Emch Theorem. It is shown that the Great Emch and Great Poncelet Theorems are equivalent and can be derived one from the other using elementary geometry, and also that both hold in the Lobachevsky plane as well. A new closure theorem is also obtained, in which the construction of closure is slightly more involved: closure occurs on a variable circle which is tangent to a fixed pair of circles. In conclusion, a combinatorial proof of Poncelet's Theorem is given, which deduces the closure principle for an arbitrary number of steps from the principle for three steps using combinatorics and number theory. Bibliography: 20 titles.

  13. Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal.

    PubMed

    Traore, Mamadou O; Sarr, Moussa D; Badji, Alioune; Bissan, Yiriba; Diawara, Lamine; Doumbia, Konimba; Goita, Soula F; Konate, Lassana; Mounkoro, Kalifa; Seck, Amadou F; Toe, Laurent; Toure, Seyni; Remme, Jan H F

    2012-01-01

    Mass treatment with ivermectin controls onchocerciasis as a public health problem, but it was not known if it could also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors are highly efficient. A longitudinal study was undertaken in three hyperendemic foci in Mali and Senegal with 15 to 17 years of annual or six-monthly ivermectin treatment in order to assess residual levels of infection and transmission, and test whether treatment could be safely stopped. This article reports the results of the final evaluations up to 5 years after the last treatment. Skin snip surveys were undertaken in 131 villages where 29,753 people were examined and 492,600 blackflies were analyzed for the presence of Onchocerca volvulus larva using a specific DNA probe. There was a declining trend in infection and transmission levels after the last treatment. In two sites the prevalence of microfilaria and vector infectivity rate were zero 3 to 4 years after the last treatment. In the third site, where infection levels were comparatively high before stopping treatment, there was also a consistent decline in infection and transmission to very low levels 3 to 5 years after stopping treatment. All infection and transmission indicators were below postulated thresholds for elimination. The study has established the proof of principle that onchocerciasis elimination with ivermectin treatment is feasible in at least some endemic foci in Africa. The study results have been instrumental for the current evolution from onchocerciasis control to elimination in Africa.

  14. Dark matter and the equivalence principle

    NASA Technical Reports Server (NTRS)

    Frieman, Joshua A.; Gradwohl, Ben-Ami

    1993-01-01

    A survey is presented of the current understanding of dark matter invoked by astrophysical theory and cosmology. Einstein's equivalence principle asserts that local measurements cannot distinguish a system at rest in a gravitational field from one that is in uniform acceleration in empty space. Recent test-methods for the equivalence principle are presently discussed as bases for testing of dark matter scenarios involving the long-range forces between either baryonic or nonbaryonic dark matter and ordinary matter.

  15. First demonstration of an emulsion multi-stage shifter for accelerator neutrino experiments in J-PARC T60

    NASA Astrophysics Data System (ADS)

    Yamada, K.; Aoki, S.; Cao, S.; Chikuma, N.; Fukuda, T.; Fukuzawa, Y.; Gonin, M.; Hayashino, T.; Hayato, Y.; Hiramoto, A.; Hosomi, F.; Inoh, T.; Iori, S.; Ishiguro, K.; Kawahara, H.; Kim, H.; Kitagawa, N.; Koga, T.; Komatani, R.; Komatsu, M.; Matsushita, A.; Mikado, S.; Minamino, A.; Mizusawa, H.; Matsumoto, T.; Matsuo, T.; Morimoto, Y.; Morishima, K.; Morishita, M.; Naganawa, N.; Nakamura, K.; Nakamura, M.; Nakamura, Y.; Nakano, T.; Nakatsuka, Y.; Nakaya, T.; Nishio, A.; Ogawa, S.; Oshima, H.; Quilain, B.; Rokujo, H.; Sato, O.; Seiya, Y.; Shibuya, H.; Shiraishi, T.; Suzuki, Y.; Tada, S.; Takahashi, S.; Yokoyama, M.; Yoshimoto, M.

    2017-06-01

    We describe the first ever implementation of a clock-based, multi-stage emulsion shifter in an accelerator neutrino experiment. The system was installed in the neutrino monitoring building at the Japan Proton Accelerator Research Complex as part of a test experiment, T60, and stable operation was maintained for a total of 126.6 days. By applying time information to emulsion films, various results were obtained. Time resolutions of 5.3-14.7 s were evaluated in an operation spanning 46.9 days (yielding division numbers of 1.4-3.8×105). By using timing and spatial information, reconstruction of coincident events consisting of high-multiplicity and vertex-contained events, including neutrino events, was performed. Emulsion events were matched to events observed by INGRID, one of the on-axis near detectors of the T2K experiment, with high reliability (98.5%), and hybrid analysis of the emulsion and INGRID events was established by means of the multi-stage shifter. The results demonstrate that the multi-stage shifter can feasibly be used in neutrino experiments.

  16. Theory and measurements of emittance preservation in plasma wakefield acceleration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frederico, Joel

    2016-12-01

    In this dissertation, we examine the preservation and measurement of emittance in the plasma wakefield acceleration blowout regime. Plasma wakefield acceleration (PWFA) is a revolutionary approach to accelerating charged particles that has been demonstrated to have the potential for gradients orders of magnitude greater than traditional approaches. The application of PWFA to the design of a linear collider will make new high energy physics research possible, but the design parameters must first be shown to be competitive with traditional methods. Emittance preservation is necessary in the design of a linear collider in order to maximize luminosity. We examine the conditionsmore » necessary for circular symmetry in the PWFA blowout regime, and demonstrate that current proposals meet these bounds. We also present an application of beam lamentation which describes the process of beam parameter and emittance matching. We show that the emittance growth saturates as a consequence of energy spread in the beam. The initial beam parameters determine the amount of emittance growth, while the contribution of energy spread is negligible. We also present a model for ion motion in the presence of a beam that is much more dense than the plasma. By combining the model of ion motion and emittance growth, we find the emittance growth due to ion motion is minimal in the case of marginal ion motion. In addition, we present a simulation that validates the ion motion model, which is under further development to examine emittance growth of both marginal and pronounced ion motion. Finally, we present a proof-of-concept of an emittance measurement which may enable the analysis of emittance preservation in future PWFA experiments.« less

  17. Canine status epilepticus treated with fosphenytoin: A proof of principle study.

    PubMed

    Patterson, Edward E; Leppik, Ilo E; Coles, Lisa D; Podell, Michael; Vite, Charles H; Bush, William; Cloyd, James C

    2015-06-01

    There are a limited number of marketed intravenous antiepileptic drugs (AEDs) available to treat status epilepticus (SE). All were first developed for chronic therapy of epilepsy, not specifically for SE. Epilepsy and canine SE (CSE) occur naturally in dogs, with prevalence, presentation, and percentage of refractory cases similar to human epilepsy. The objective of this study was to determine if CSE treated with fosphenytoin (FOS) results in a similar responder rate as for people. A randomized clinical trial was performed for dogs with CSE. Dogs who presented during a seizure or who had additional seizures after enrolling received intravenous (i.v.) benzodiazepine (BZD) followed immediately by intravenous infusion of 15 mg/kg phenytoin equivalent (PE) of fosphenytoin (FOS) or saline placebo (PBO). If seizures continued, additional AEDs were administered per the standard of care for veterinary patients. Total and unbound plasma phenytoin (PHT) concentrations were measured. Consent was obtained for 50 dogs with CSE. Thirty-one had additional motor seizures and were randomized to the study intervention (22 FOS and 9 PBO). There was a statistically significant difference in the 12 h responder rate, with 63% in the FOS group versus 22% in the placebo group (p = 0.043) having no further seizures. The unbound PHT concentrations at 30 and 60 min were within the therapeutic concentrations for people (1-2 μg/ml) with the exception of one dog. There was mild vomiting in 36% of the FOS group (7/22) within 20 min of FOS administration and none of the placebo group (0/9) (p = 0.064). This proof of concept study provides the first evidence that FOS is tolerated and effective in canine SE at PHT concentrations clinically relevant for human SE. Furthermore, naturally occurring CSE can be utilized as a translational platform for future studies of novel SE compounds. © 2015 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against

  18. 5 CFR 843.406 - Proof of dependency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Proof of dependency. 843.406 Section 843.406 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Proof of dependency. (a) A child is considered to have been dependent on the deceased employee or...

  19. 5 CFR 843.406 - Proof of dependency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Proof of dependency. 843.406 Section 843.406 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Proof of dependency. (a) A child is considered to have been dependent on the deceased employee or...

  20. 5 CFR 843.406 - Proof of dependency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Proof of dependency. 843.406 Section 843.406 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Proof of dependency. (a) A child is considered to have been dependent on the deceased employee or...

  1. 5 CFR 843.406 - Proof of dependency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Proof of dependency. 843.406 Section 843.406 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Proof of dependency. (a) A child is considered to have been dependent on the deceased employee or...

  2. 5 CFR 843.406 - Proof of dependency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Proof of dependency. 843.406 Section 843.406 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Proof of dependency. (a) A child is considered to have been dependent on the deceased employee or...

  3. Electromagnetic Safety of Spacecraft During Active Experiments with the Use of Plasma Accelerators and Ion Injectors

    NASA Astrophysics Data System (ADS)

    Plokhikh, Andrey; Popov, Garri; Shishkin, Gennady; Antropov, Nikolay; Vazhenin, Nikolay; Soganova, Galina

    Works under the development and application of stationary and pulsed plasma accelerators of charged particles conducted at the Moscow Aviation Institute and Research Institute of Applied Mechanics and Electrodynamics during over 40 years, active experiments on board meteorological rockets, artificial Earth satellites and "Mir" orbital station including [1], allowed to obtain data on the influence of pulsed and continuous plasma injection with the given parameters on the drop of energetic particles out of the radiation belts, efficiency of artificial excitation and propagation of electromagnetic waves in ELF and VLF ranges, and evolution of artificial plasma formations in different regions of ionosphere. Variation of the near-spacecraft electromagnetic environment related to the operation of plasma injectors was registered during active experiments along with the global electrodynamic processes. The measured electromagnetic fields are of rather high intensity and occupy frequency spectrum from some Hz to tens of GHz that may be of definite danger for the operation of spacecraft and its onboard systems. Analysis for the known test data is presented in the paper and methods are discussed for the diagnostics and modeling under laboratory conditions of radiative processes proceeding at the operation of plasma accelerators and ion injectors used while making active space experiments. Great attention is paid to the methodological and metrological bases for making radio measurements in vacuum chambers, design concept and hardware configuration of ground special-purpose instrumentation scientific complexes [2]. Basic requirements are formulated for the measurements and analysis of electromagnetic fields originating during the operation of plasma accelerators, including the radiative induced and conductive components inside the spacecraft, as well as the wave emission and excitation outside the spacecraft, in the ionosphere including. Measurement results for the intrinsic

  4. [Burden of proof in medical cases--presumption of fact and prima facie evidence. 1. Burden of proof].

    PubMed

    Sliwka, Marcin

    2004-01-01

    The aim of this paper was to present the main rules concerning the burden of proof in polish civil trials, including medical cases. This paper also describes the subject of evidence were presented and explained. The court influence on evidence procedure was also analysed. The effect of the institution of informed consent on burden of proof in polish civil law is also described. This paper includes numerous High Court sentences on evidential and medical issues.

  5. Southern California Regional Technology Acceleration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ochoa, Rosibel; Rasochova, Lada

    2014-09-30

    UC San Diego and San Diego State University are partnering to address these deficiencies in the renewable energy space in the greater San Diego region, accelerating the movement of clean energy innovation from the university laboratory into the marketplace, building on the proven model of the William J. von Liebig Center’s (vLC’s) Proof of Concept (POC) program and virtualizing the effort to enable a more inclusive environment for energy innovation and expansion of the number of clean energy start-ups and/or technology licenses in greater California.

  6. Conceptual design of a 15-TW pulsed-power accelerator for high-energy-density–physics experiments

    DOE PAGES

    Spielman, R. B.; Froula, D. H.; Brent, G.; ...

    2017-06-21

    We have developed a conceptual design of a 15-TW pulsed-power accelerator based on the linear-transformer-driver (LTD) architecture described by Stygar [W. A. Stygar et al., Phys. Rev. ST Accel. Beams 18, 110401 (2015)]. The driver will allow multiple, high-energy-density experiments per day in a university environment and, at the same time, will enable both fundamental and integrated experiments that are scalable to larger facilities. In this design, many individual energy storage units (bricks), each composed of two capacitors and one switch, directly drive the target load without additional pulse compression. Ten LTD modules in parallel drive the load. Each modulemore » consists of 16 LTD cavities connected in series, where each cavity is powered by 22 bricks connected in parallel. This design stores up to 2.75 MJ and delivers up to 15 TW in 100 ns to the constant-impedance, water-insulated radial transmission lines. The transmission lines in turn deliver a peak current as high as 12.5 MA to the physics load. To maximize its experimental value and flexibility, the accelerator is coupled to a modern, multibeam laser facility (four beams with up to 5 kJ in 10 ns and one beam with up to 2.6 kJ in 100 ps or less) that can provide auxiliary heating of the physics load. The lasers also enable advanced diagnostic techniques such as x-ray Thomson scattering and multiframe and three-dimensional radiography. In conclusion, the coupled accelerator-laser facility will be the first of its kind and be capable of conducting unprecedented high-energy-density-physics experiments.« less

  7. Conceptual design of a 15-TW pulsed-power accelerator for high-energy-density–physics experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spielman, R. B.; Froula, D. H.; Brent, G.

    We have developed a conceptual design of a 15-TW pulsed-power accelerator based on the linear-transformer-driver (LTD) architecture described by Stygar [W. A. Stygar et al., Phys. Rev. ST Accel. Beams 18, 110401 (2015)]. The driver will allow multiple, high-energy-density experiments per day in a university environment and, at the same time, will enable both fundamental and integrated experiments that are scalable to larger facilities. In this design, many individual energy storage units (bricks), each composed of two capacitors and one switch, directly drive the target load without additional pulse compression. Ten LTD modules in parallel drive the load. Each modulemore » consists of 16 LTD cavities connected in series, where each cavity is powered by 22 bricks connected in parallel. This design stores up to 2.75 MJ and delivers up to 15 TW in 100 ns to the constant-impedance, water-insulated radial transmission lines. The transmission lines in turn deliver a peak current as high as 12.5 MA to the physics load. To maximize its experimental value and flexibility, the accelerator is coupled to a modern, multibeam laser facility (four beams with up to 5 kJ in 10 ns and one beam with up to 2.6 kJ in 100 ps or less) that can provide auxiliary heating of the physics load. The lasers also enable advanced diagnostic techniques such as x-ray Thomson scattering and multiframe and three-dimensional radiography. In conclusion, the coupled accelerator-laser facility will be the first of its kind and be capable of conducting unprecedented high-energy-density-physics experiments.« less

  8. Design and Fabrication of a Differential Electrostatic Accelerometer for Space-Station Testing of the Equivalence Principle.

    PubMed

    Han, Fengtian; Liu, Tianyi; Li, Linlin; Wu, Qiuping

    2016-08-10

    The differential electrostatic space accelerometer is an equivalence principle (EP) experiment instrument proposed to operate onboard China's space station in the 2020s. It is designed to compare the spin-spin interaction between two rotating extended bodies and the Earth to a precision of 10(-12), which is five orders of magnitude better than terrestrial experiment results to date. To achieve the targeted test accuracy, the sensitive space accelerometer will use the very soft space environment provided by a quasi-drag-free floating capsule and long-time observation of the free-fall mass motion for integration of the measurements over 20 orbits. In this work, we describe the design and capability of the differential accelerometer to test weak space acceleration. Modeling and simulation results of the electrostatic suspension and electrostatic motor are presented based on attainable space microgravity condition. Noise evaluation shows that the electrostatic actuation and residual non-gravitational acceleration are two major noise sources. The evaluated differential acceleration noise is 1.01 × 10(-9) m/s²/Hz(1/2) at the NEP signal frequency of 0.182 mHz, by neglecting small acceleration disturbances. The preliminary work on development of the first instrument prototype is introduced for on-ground technological assessments. This development has already confirmed several crucial fabrication processes and measurement techniques and it will open the way to the construction of the final differential space accelerometer.

  9. Design and Fabrication of a Differential Electrostatic Accelerometer for Space-Station Testing of the Equivalence Principle

    PubMed Central

    Han, Fengtian; Liu, Tianyi; Li, Linlin; Wu, Qiuping

    2016-01-01

    The differential electrostatic space accelerometer is an equivalence principle (EP) experiment instrument proposed to operate onboard China’s space station in the 2020s. It is designed to compare the spin-spin interaction between two rotating extended bodies and the Earth to a precision of 10−12, which is five orders of magnitude better than terrestrial experiment results to date. To achieve the targeted test accuracy, the sensitive space accelerometer will use the very soft space environment provided by a quasi-drag-free floating capsule and long-time observation of the free-fall mass motion for integration of the measurements over 20 orbits. In this work, we describe the design and capability of the differential accelerometer to test weak space acceleration. Modeling and simulation results of the electrostatic suspension and electrostatic motor are presented based on attainable space microgravity condition. Noise evaluation shows that the electrostatic actuation and residual non-gravitational acceleration are two major noise sources. The evaluated differential acceleration noise is 1.01 × 10−9 m/s2/Hz1/2 at the NEP signal frequency of 0.182 mHz, by neglecting small acceleration disturbances. The preliminary work on development of the first instrument prototype is introduced for on-ground technological assessments. This development has already confirmed several crucial fabrication processes and measurement techniques and it will open the way to the construction of the final differential space accelerometer. PMID:27517927

  10. Signature energetic analysis of accelerate electron beam after first acceleration station by accelerating stand of Joint Institute for Nuclear Research

    NASA Astrophysics Data System (ADS)

    Sledneva, A. S.; Kobets, V. V.

    2017-06-01

    The linear electron accelerator based on the LINAC - 800 accelerator imported from the Netherland is created at Joint Institute for Nuclear Research in the framework of the project on creation of the Testbed with an electron beam of a linear accelerator with an energy up to 250 MV. Currently two accelerator stations with a 60 MV energy of a beam are put in operation and the work is to put the beam through accelerating section of the third accelerator station. The electron beam with an energy of 23 MeV is used for testing the crystals (BaF2, CsI (native), and LYSO) in order to explore the opportunity to use them in particle detectors in experiments: Muon g-2, Mu2e, Comet, whose preparation requires a detailed study of the detectors properties such as their irradiation by the accelerator beams.

  11. 6 CFR 27.325 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Burden of proof. 27.325 Section 27.325 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.325 Burden of proof. The Assistant Secretary bears the initial...

  12. 6 CFR 27.325 - Burden of proof.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Burden of proof. 27.325 Section 27.325 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.325 Burden of proof. The Assistant Secretary bears the initial...

  13. 6 CFR 27.325 - Burden of proof.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Burden of proof. 27.325 Section 27.325 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.325 Burden of proof. The Assistant Secretary bears the initial...

  14. 6 CFR 27.325 - Burden of proof.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Burden of proof. 27.325 Section 27.325 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.325 Burden of proof. The Assistant Secretary bears the initial...

  15. 6 CFR 27.325 - Burden of proof.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Burden of proof. 27.325 Section 27.325 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.325 Burden of proof. The Assistant Secretary bears the initial...

  16. Deriving Safety Cases from Machine-Generated Proofs

    NASA Technical Reports Server (NTRS)

    Basir, Nurlida; Fischer, Bernd; Denney, Ewen

    2009-01-01

    Proofs provide detailed justification for the validity of claims and are widely used in formal software development methods. However, they are often complex and difficult to understand, because they use machine-oriented formalisms; they may also be based on assumptions that are not justified. This causes concerns about the trustworthiness of using formal proofs as arguments in safety-critical applications. Here, we present an approach to develop safety cases that correspond to formal proofs found by automated theorem provers and reveal the underlying argumentation structure and top-level assumptions. We concentrate on natural deduction proofs and show how to construct the safety cases by covering the proof tree with corresponding safety case fragments.

  17. 21 CFR 1315.58 - Burden of proof.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Burden of proof. 1315.58 Section 1315.58 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE IMPORTATION AND PRODUCTION QUOTAS FOR EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLPROPANOLAMINE Hearings § 1315.58 Burden of proof. (a) At any hearing...

  18. 21 CFR 1315.58 - Burden of proof.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Burden of proof. 1315.58 Section 1315.58 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE IMPORTATION AND PRODUCTION QUOTAS FOR EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLPROPANOLAMINE Hearings § 1315.58 Burden of proof. (a) At any hearing...

  19. 21 CFR 1315.58 - Burden of proof.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Burden of proof. 1315.58 Section 1315.58 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE IMPORTATION AND PRODUCTION QUOTAS FOR EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLPROPANOLAMINE Hearings § 1315.58 Burden of proof. (a) At any hearing...

  20. 21 CFR 1315.58 - Burden of proof.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Burden of proof. 1315.58 Section 1315.58 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE IMPORTATION AND PRODUCTION QUOTAS FOR EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLPROPANOLAMINE Hearings § 1315.58 Burden of proof. (a) At any hearing...

  1. 21 CFR 1315.58 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Burden of proof. 1315.58 Section 1315.58 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE IMPORTATION AND PRODUCTION QUOTAS FOR EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLPROPANOLAMINE Hearings § 1315.58 Burden of proof. (a) At any hearing...

  2. 7 CFR 1430.605 - Proof of production.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... commercial production, including any dumped production and dairy cow purchases, for each month of the... by the dairy operation. (d) Adequate proof of dairy cow additions to the milking herd during the... any other documents available to confirm the cow purchases. (e) If adequate proof of normally marketed...

  3. Gaming the System: Developing an Educational Game for Securing Principles of Arterial Blood Gases.

    PubMed

    Boyd, Cory Ann; Warren, Jonah; Glendon, Mary Ann

    2016-01-01

    This article describes the development process for creating a digital educational mini game prototype designed to provide practice opportunities for learning fundamental principles of arterial blood gases. Mini games generally take less than an hour to play and focus on specific subject matter. An interdisciplinary team of faculty from two universities mentored student game developers to design a digital educational mini game prototype. Sixteen accelerated bachelor of science in nursing students collaborated with game development students and playtested the game prototype during the last semester of their senior year in nursing school. Playtesting is a form of feedback that supports an iterative design process that is critical to game development. A 10-question survey was coupled with group discussions addressing five broad themes of an archetypical digital educational mini game to yield feedback on game design, play, and content. Four rounds of playtesting and incorporating feedback supported the iterative process. Accelerated bachelor of science in nursing student playtester feedback suggests that the digital educational mini game prototype has potential for offering an engaging, playful game experience that will support securing the fundamental principles of arterial blood gases. Next steps are to test the digital educational mini game for teaching and learning effectiveness. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. 14 CFR 13.223 - Standard of proof.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Standard of proof. 13.223 Section 13.223 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... proof. The administrative law judge shall issue an initial decision or shall rule in a party's favor...

  5. 14 CFR 13.223 - Standard of proof.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Standard of proof. 13.223 Section 13.223 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES... proof. The administrative law judge shall issue an initial decision or shall rule in a party's favor...

  6. Acceleration Environment of the International Space Station

    NASA Technical Reports Server (NTRS)

    McPherson, Kevin; Kelly, Eric; Keller, Jennifer

    2009-01-01

    Measurement of the microgravity acceleration environment on the International Space Station has been accomplished by two accelerometer systems since 2001. The Microgravity Acceleration Measurement System records the quasi-steady microgravity environment, including the influences of aerodynamic drag, vehicle rotation, and venting effects. Measurement of the vibratory/transient regime, comprised of vehicle, crew, and equipment disturbances, has been accomplished by the Space Acceleration Measurement System-II. Until the arrival of the Columbus Orbital Facility and the Japanese Experiment Module, the location of these sensors, and therefore, the measurement of the microgravity acceleration environment, has been limited to within the United States Laboratory. Japanese Aerospace Exploration Agency has developed a vibratory acceleration measurement system called the Microgravity Measurement Apparatus which will be deployed within the Japanese Experiment Module to make distributed measurements of the Japanese Experiment Module's vibratory acceleration environment. Two Space Acceleration Measurement System sensors from the United States Laboratory will be re-deployed to support vibratory acceleration data measurement within the Columbus Orbital Facility. The additional measurement opportunities resulting from the arrival of these new laboratories allows Principal Investigators with facilities located in these International Space Station research laboratories to obtain microgravity acceleration data in support of their sensitive experiments. The Principal Investigator Microgravity Services project, at NASA Glenn Research Center, in Cleveland, Ohio, has supported acceleration measurement systems and the microgravity scientific community through the processing, characterization, distribution, and archival of the microgravity acceleration data obtained from the International Space Station acceleration measurement systems. This paper summarizes the PIMS capabilities available

  7. 47 CFR 76.1704 - Proof-of-performance test data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Proof-of-performance test data. 76.1704 Section 76.1704 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Documents to be Maintained for Inspection § 76.1704 Proof-of-performance test data. (a) The proof of...

  8. 47 CFR 76.1704 - Proof-of-performance test data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Proof-of-performance test data. 76.1704 Section 76.1704 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Documents to be Maintained for Inspection § 76.1704 Proof-of-performance test data. (a) The proof of...

  9. Educating a Diverse Workforce: The Student of Color Experience in a Research University's Accelerated Undergraduate Nursing Program

    ERIC Educational Resources Information Center

    Johnson-Campbell, Tanisha

    2018-01-01

    This study is an investigation into a 15-month accelerated undergraduate nursing program and the minority student experience. Using a mixed methods approach, this research addressed the following questions: 1. What was the retention rate for students enrolled in the accelerated nursing bachelor's program and how did that differ by race? 2. What…

  10. Impact of Proof Validation on Proof Writing in Abstract Algebra

    ERIC Educational Resources Information Center

    Powers, Robert A.; Craviotto, Cathleen; Grassl, Richard M.

    2010-01-01

    Many undergraduate students have difficulty writing mathematical proofs even though this skill is important for the development of future teachers and those who may be involved in instruction or training as a graduate student or supervisor. In addition, research indicates that mathematics majors and secondary education mathematics majors possess…

  11. Experiments on 1,000 km/s flyer acceleration and collisions

    NASA Astrophysics Data System (ADS)

    Karasik, Max; Weaver, J. L.; Aglitskiy, Y.; Kehne, D. M.; Zalesak, S. T.; Velikovich, A. L.; Oh, J.; Serlin, V.; Obenschain, S. P.

    2012-10-01

    We will present results from follow-on experiments to the record-high velocities achieved using the ultra-uniform deep-uv drive of the Nike KrF laser [Karasik et al, Phys. Plasmas 17, 056317 (2010)], in which highly accelerated planar foils of deuterated polystyrene were made to collide with a witness foil to produce ˜1 Gbar shock pressures and result in heating of matter to thermonuclear temperatures. Such velocities may indicate a path to lower minimum energy required for central ignition. Still higher velocities and higher target densities are required for impact fast ignition. New results give velocity of >1,100 km/s achieved through improvements in pulseshaping. Variation of second foil parameters results in significant change in fusion neutron production on impact. In-flight target density is inferred from target heating upon collision via DD neutron time-of-flight ion temperature measurement. Availability of pressures generated by collisions of such highly accelerated flyers may provide an experimental platform for study of matter at extreme conditions. Work is supported by US DOE (NNSA).

  12. CLARA conceptual design report

    NASA Astrophysics Data System (ADS)

    Clarke, J. A.; Angal-Kalinin, D.; Bliss, N.; Buckley, R.; Buckley, S.; Cash, R.; Corlett, P.; Cowie, L.; Cox, G.; Diakun, G. P.; Dunning, D. J.; Fell, B. D.; Gallagher, A.; Goudket, P.; Goulden, A. R.; Holland, D. M. P.; Jamison, S. P.; Jones, J. K.; Kalinin, A. S.; Liggins, W.; Ma, L.; Marinov, K. B.; Martlew, B.; McIntosh, P. A.; McKenzie, J. W.; Middleman, K. J.; Militsyn, B. L.; Moss, A. J.; Muratori, B. D.; Roper, M. D.; Santer, R.; Saveliev, Y.; Snedden, E.; Smith, R. J.; Smith, S. L.; Surman, M.; Thakker, T.; Thompson, N. R.; Valizadeh, R.; Wheelhouse, A. E.; Williams, P. H.; Bartolini, R.; Martin, I.; Barlow, R.; Kolano, A.; Burt, G.; Chattopadhyay, S.; Newton, D.; Wolski, A.; Appleby, R. B.; Owen, H. L.; Serluca, M.; Xia, G.; Boogert, S.; Lyapin, A.; Campbell, L.; McNeil, B. W. J.; Paramonov, V. V.

    2014-05-01

    This report describes the conceptual design of a proposed free electron laser test facility called CLARA that will be a major upgrade to the existing VELA accelerator test facility at Daresbury Laboratory in the UK. CLARA will be able to test a number of new free electron laser schemes that have been proposed but require a proof of principle experiment to confirm that they perform as predicted. The primary focus of CLARA will be on ultra short photon pulse generation which will take free electron lasers into a whole new regime, enabling a new area of photon science to emerge.

  13. 49 CFR 8.21 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.21 Burden of proof. For the purpose of determinations to be made under §§ 8.13, 8.15, and 8.17, the burden of proof is on the originating Departmental agency to...

  14. 49 CFR 8.21 - Burden of proof.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Classification/Declassification of Information § 8.21 Burden of proof. For the purpose of determinations to be made under §§ 8.13, 8.15, and 8.17, the burden of proof is on the originating Departmental agency to...

  15. 14 CFR 23.641 - Proof of strength.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Proof of strength. 23.641 Section 23.641 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....641 Proof of strength. The strength of stressed-skin wings must be proven by load tests or by combined...

  16. 14 CFR 23.641 - Proof of strength.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Proof of strength. 23.641 Section 23.641 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....641 Proof of strength. The strength of stressed-skin wings must be proven by load tests or by combined...

  17. 21 CFR 1316.56 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Burden of proof. 1316.56 Section 1316.56 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ADMINISTRATIVE FUNCTIONS, PRACTICES, AND PROCEDURES Administrative Hearings § 1316.56 Burden of proof. At any hearing, the proponent for the issuance...

  18. Proof of factorization using background field method of QCD

    NASA Astrophysics Data System (ADS)

    Nayak, Gouranga C.

    2010-02-01

    Factorization theorem plays the central role at high energy colliders to study standard model and beyond standard model physics. The proof of factorization theorem is given by Collins, Soper and Sterman to all orders in perturbation theory by using diagrammatic approach. One might wonder if one can obtain the proof of factorization theorem through symmetry considerations at the lagrangian level. In this paper we provide such a proof.

  19. Proof of factorization using background field method of QCD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nayak, Gouranga C.

    Factorization theorem plays the central role at high energy colliders to study standard model and beyond standard model physics. The proof of factorization theorem is given by Collins, Soper and Sterman to all orders in perturbation theory by using diagrammatic approach. One might wonder if one can obtain the proof of factorization theorem through symmetry considerations at the lagrangian level. In this paper we provide such a proof.

  20. Chemical Principles Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1970-01-01

    This is the first of a new series of brief ancedotes about materials and phenomena which exemplify chemical principles. Examples include (1) the sea-lab experiment illustrating principles of the kinetic theory of gases, (2) snow-making machines illustrating principles of thermodynamics in gas expansions and phase changes, and (3) sunglasses that…

  1. Accelerating Calculations of Reaction Dissipative Particle Dynamics in LAMMPS

    DTIC Science & Technology

    2017-05-17

    order reaction mechanism, the best acceleration was 6.1 times. For a larger, more chemically detailed mechanism, the best acceleration exceeded 60 times...simulations at previously inaccessible scales. A principle feature of DPD-RX is its ability to model chemical reactions within each CG particle. The...change in composition due to chemical reactions is described by a system of ordinary differential equations (ODEs) that are evaluated at each DPD time

  2. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities was flown aboard Shuttle on STS-40. The instrument is designed to measure and record the Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarefied flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument detects aerodynamic behavior of the Shuttle while in low-earth orbit. A 2-h orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low-frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight liner corrections for drift.

  3. DEM simulation of granular flows in a centrifugal acceleration field

    NASA Astrophysics Data System (ADS)

    Cabrera, Miguel Angel; Peng, Chong; Wu, Wei

    2017-04-01

    The main purpose of mass-flow experimental models is abstracting distinctive features of natural granular flows, and allow its systematic study in the laboratory. In this process, particle size, space, time, and stress scales must be considered for the proper representation of specific phenomena [5]. One of the most challenging tasks in small scale models, is matching the range of stresses and strains among the particle and fluid media observed in a field event. Centrifuge modelling offers an alternative to upscale all gravity-driven processes, and it has been recently employed in the simulation of granular flows [1, 2, 3, 6, 7]. Centrifuge scaling principles are presented in Ref. [4], collecting a wide spectrum of static and dynamic models. However, for the case of kinematic processes, the non-uniformity of the centrifugal acceleration field plays a major role (i.e., Coriolis and inertial effects). In this work, we discuss a general formulation for the centrifugal acceleration field, implemented in a discrete element model framework (DEM), and validated with centrifuge experimental results. Conventional DEM simulations relate the volumetric forces as a function of the gravitational force Gp = mpg. However, in the local coordinate system of a rotating centrifuge model, the cylindrical centrifugal acceleration field needs to be included. In this rotating system, the centrifugal acceleration of a particle depends on the rotating speed of the centrifuge, as well as the position and speed of the particle in the rotating model. Therefore, we obtain the formulation of centrifugal acceleration field by coordinate transformation. The numerical model is validated with a series of centrifuge experiments of monodispersed glass beads, flowing down an inclined plane at different acceleration levels and slope angles. Further discussion leads to the numerical parameterization necessary for simulating equivalent granular flows under an augmented acceleration field. The premise of

  4. From Inductive Reasoning to Proof

    ERIC Educational Resources Information Center

    Yopp, David A.

    2009-01-01

    Mathematical proof is an expression of deductive reasoning (drawing conclusions from previous assertions). However, it is often inductive reasoning (conclusions drawn on the basis of examples) that helps learners form their deductive arguments, or proof. In addition, not all inductive arguments generate more formal arguments. This article draws a…

  5. Cellular Telephones Measure Activity and Lifespace in Community-Dwelling Adults: Proof of Principle

    PubMed Central

    Schenk, Ana Katrin; Witbrodt, Bradley C.; Hoarty, Carrie A.; Carlson, Richard H.; Goulding, Evan H.; Potter, Jane F.; Bonasera, Stephen J.

    2011-01-01

    OBJECTIVES To describe a system that uses off-the-shelf sensor and telecommunication technologies to continuously measure individual lifespace and activity levels in a novel way. DESIGN Proof of concept involving three field trials of 30, 30, and 21 days. SETTING Omaha, Nebraska, metropolitan and surrounding rural region. PARTICIPANTS Three participants (48-year-old man, 33-year-old woman, and 27-year-old male), none with any functional limitations. MEASUREMENTS Cellular telephones were used to detect in-home position and in-community location and to measure physical activity. Within the home, cellular telephones and Bluetooth transmitters (beacons) were used to locate participants at room-level resolution. Outside the home, the same cellular telephones and global positioning system (GPS) technology were used to locate participants at a community-level resolution. Physical activity was simultaneously measured using the cellular telephone accelerometer. RESULTS This approach had face validity to measure activity and lifespace. More importantly, this system could measure the spatial and temporal organization of these metrics. For example, an individual’s lifespace was automatically calculated across multiple time intervals. Behavioral time budgets showing how people allocate time to specific regions within the home were also automatically generated. CONCLUSION Mobile monitoring shows much promise as an easily deployed system to quantify activity and lifespace, important indicators of function, in community-dwelling adults. PMID:21288235

  6. Computation of linear acceleration through an internal model in the macaque cerebellum

    PubMed Central

    Laurens, Jean; Meng, Hui; Angelaki, Dora E.

    2013-01-01

    A combination of theory and behavioral findings has supported a role for internal models in the resolution of sensory ambiguities and sensorimotor processing. Although the cerebellum has been proposed as a candidate for implementation of internal models, concrete evidence from neural responses is lacking. Here we exploit un-natural motion stimuli, which induce incorrect self-motion perception and eye movements, to explore the neural correlates of an internal model proposed to compensate for Einstein’s equivalence principle and generate neural estimates of linear acceleration and gravity. We show that caudal cerebellar vermis Purkinje cells and cerebellar nuclei neurons selective for actual linear acceleration also encode erroneous linear acceleration, as expected from the internal model hypothesis, even when no actual linear acceleration occurs. These findings provide strong evidence that the cerebellum might be involved in the implementation of internal models that mimic physical principles to interpret sensory signals, as previously hypothesized by theorists. PMID:24077562

  7. Mathematicians' Perspectives on Features of a Good Pedagogical Proof

    ERIC Educational Resources Information Center

    Lai, Yvonne; Weber, Keith; Mejia-Ramos, Juan Pablo

    2012-01-01

    In this article, we report two studies investigating what mathematicians value in a pedagogical proof. Study 1 is a qualitative study of how eight mathematicians revised two proofs that would be presented in a course for mathematics majors. These mathematicians thought that introductory and concluding sentences should be included in the proofs,…

  8. SIN accelerator, operational experience and improvement programs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joho, W.; Olivo, M.; Stammbach, T.

    1977-06-01

    The SIN meson facility, in operation since 1974, consists of a 590 MeV ring cyclotron for protons and a 72 MeV injector cyclotron. The average beam current on target is presently about 50 ..mu..A, the peak being 112 ..mu..A. Extraction efficiency, once considered a severe handicap for cyclotrons, is now 99.6 to 99.9% for the ring cyclotron and about 90% for the injector. Many improvements in both accelerators allow single turn extraction in the ring cyclotron. The present current limit is given by the injector, while the ring itself could accept now a 600 ..mu..A beam, with 2 to 4more » mA as an ultimate limit. Some muon experiments require a pulsed beam with on-off times in the order of the lifetime of the muon. First trials with beam pulse frequencies of 200 and 400 kHz and a 50% duty cycle have been successful.« less

  9. 25 CFR 75.11 - Proof of relationship.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Proof of relationship. 75.11 Section 75.11 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT REVISION OF THE MEMBERSHIP ROLL OF THE EASTERN BAND OF CHEROKEE INDIANS, NORTH CAROLINA § 75.11 Proof of relationship. If the applicant's...

  10. 25 CFR 75.11 - Proof of relationship.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Proof of relationship. 75.11 Section 75.11 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT REVISION OF THE MEMBERSHIP ROLL OF THE EASTERN BAND OF CHEROKEE INDIANS, NORTH CAROLINA § 75.11 Proof of relationship. If the applicant's...

  11. 33 CFR 20.702 - Burden of proof.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Burden of proof. 20.702 Section 20.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF....702 Burden of proof. (a) Except for an affirmative defense, or as provided by paragraph (b) of this...

  12. 33 CFR 20.702 - Burden of proof.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Burden of proof. 20.702 Section 20.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF....702 Burden of proof. (a) Except for an affirmative defense, or as provided by paragraph (b) of this...

  13. 33 CFR 20.702 - Burden of proof.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Burden of proof. 20.702 Section 20.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF....702 Burden of proof. (a) Except for an affirmative defense, or as provided by paragraph (b) of this...

  14. 33 CFR 20.702 - Burden of proof.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Burden of proof. 20.702 Section 20.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF....702 Burden of proof. (a) Except for an affirmative defense, or as provided by paragraph (b) of this...

  15. 33 CFR 20.702 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Burden of proof. 20.702 Section 20.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF....702 Burden of proof. (a) Except for an affirmative defense, or as provided by paragraph (b) of this...

  16. A Proof of the Occupancy Principle and the Mean-Transit-Time Theorem for Compartmental Models

    PubMed Central

    RAMAKRISHNAN, RAJASEKHAR; LEONARD, EDWARD F.; DELL, RALPH B.

    2012-01-01

    The occupancy principle and the mean-transit-time theorem are derived for the passage of a tracer through a system that can be described by a general pool model. It is proved, using matrix theory, that if (and only if) tracer entering the system labels equally all tracee fluxes into the system, then the integral of the tracer concentration is the same in all the pools. It is also proved that if, in addition, all flow out of the system is through the observation point, the first moment of the tracer concentration at the observation point can be used to calculate the total amount of trace in the system. The necessity of this condition is analyzed. Examples are given of models in which the occupancy principle and the mean-transit-time theorem hold or do not hold. PMID:22328793

  17. A Novel Permanent Magnetic Angular Acceleration Sensor

    PubMed Central

    Zhao, Hao; Feng, Hao

    2015-01-01

    Angular acceleration is an important parameter for status monitoring and fault diagnosis of rotary machinery. Therefore, we developed a novel permanent magnetic angular acceleration sensor, which is without rotation angle limitations and could directly measure the instantaneous angular acceleration of the rotating system. The sensor rotor only needs to be coaxially connected with the rotating system, which enables convenient sensor installation. For the cup structure of the sensor rotor, it has a relatively small rotational inertia. Due to the unique mechanical structure of the sensor, the output signal of the sensor can be directed without a slip ring, which avoids signal weakening effect. In this paper, the operating principle of the sensor is described, and simulated using finite element method. The sensitivity of the sensor is calibrated by torsional pendulum and angle sensor, yielding an experimental result of about 0.88 mV/(rad·s−2). Finally, the angular acceleration of the actual rotating system has been tested, using both a single-phase asynchronous motor and a step motor. Experimental result confirms the operating principle of the sensor and indicates that the sensor has good practicability. PMID:26151217

  18. 44 CFR 75.3 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Burden of proof. 75.3 Section 75.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROPERTIES UNDER SELF-INSURANCE PLAN General § 75.3 Burden of proof. In any application made by a State to...

  19. 14 CFR 23.307 - Proof of structure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Proof of structure. 23.307 Section 23.307... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Structure General § 23.307 Proof of structure. (a) Compliance with the strength and deformation requirements of § 23.305 must be shown for each...

  20. 44 CFR 75.3 - Burden of proof.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Burden of proof. 75.3 Section 75.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROPERTIES UNDER SELF-INSURANCE PLAN General § 75.3 Burden of proof. In any application made by a State to...