Due to flashover problems, Austin Research Associates, Inc. may be forced to perform its proof-of-principle autoresonant collective ion acceleration experiment at electron beam parameters of 2.25 MeV and 15 kA rather than the intended 3.0 MeV and 30 kA. W...
National Technical Information Service (NTIS)
IFA proof-of-principle experiments (completed on the IFA-1 system) have already demonstrated accurately-controlled motion of the potential well at the head of an IREB, and IFA ion data sets (H exp + , D exp + , He exp ++ ) imply that controlled accelerati...
Generator and diode problems have reduced electron beam parameters for the proof-of-principle autoresonant collective ion acceleration experiment from 3 MeV, 30 kA, and 200 ns to 2.25 MeV, 15 kA, and 100 ns. This reduction limits acceleration of hydrogen ...
The Tritium Proof-of-Principle (TPOP) pellet injector was designed and built by Oak Ridge National Laboratory (ORNL) to evaluate the production and acceleration of tritium pellets for fueling future fusion reactors. The injector uses the pipe-gun concept to form pellets directly in a short liquid-helium-cooled section of the barrel. Pellets are ...
Energy Citations Database
Due to flashover problems, Austin Research Associates, Inc. may be forced to perform its proof-of-principle autoresonant collective ion acceleration experiment at electron beam parameters of 2.25 MeV and 15 kA rather than the intended 3.0 MeV and 30 kA. We show that the original experimental goals still can be achieved provided the ...
DOE Information Bridge
The MBE-4 proof-of-principle experiment uses an induction linac to accelerate four Cs+ beams from injection at 200 kV to almost 1MV. When completed in the summer of 1987 it will be 17.2 meters long and have 24 acceleration gaps and 6 diagnostic gaps. Care...
The Tritium Proof-of-Principle (TPOP) pellet injector was designed and built by Oak Ridge National Laboratory (ORNL) to evaluate the production and acceleration of tritium pellets for fueling future fision reactors. The injector uses the pipe-gun concept to form pellets directly in a short liquid-helium-cooled section of the barrel. Pellets are ...
Several proof-of-principle laser accelerator experiments turned a long-wavelength of a CO{sub 2} laser to advantage. Ongoing advancement to multi-terawatt femtosecond CO{sub 2} lasers opens new venues for next-generation laser acceleration research.
The problem of beam background in Squid Polarimetry is not without residual benefits. The authors may deliberately generate beam background by gently kicking the beam at the spin tune frequency. This signal may be used to accomplish a simple and accurate absolute calibration of the polarimeter. The authors present details of beam background calculations and their application to polarimeter ...
We recently achieved the first experimental observation of laser-driven particle acceleration of relativistic electrons from a single Gaussian near-infrared laser beam in a semi-infinite vacuum. This article presents an in-depth account of key aspects of the experiment. An analysis of the transverse and longitudinal forces acting on the electron beam is ...
We present a two stage Inverse Free Electron Laser accelerator proposed for construction at the UCLA Neptune Lab. Proof-of-principle experiments on the IFEL scheme have been carried out succesfully. This experiment is intended to achieve a 100 Mev energy gain, staging two IFEL modules. It will use the 16 Mev ...
NASA Astrophysics Data System (ADS)
We present a two stage Inverse Free Electron Laser accelerator proposed for construction at the UCLA Neptune Lab. Proof-of-principle experiments on the IFEL scheme have been carried out successfully. This experiment is intended to achieve a 100 MeV energy gain, staging two IFEL modules. It will use a 16 MeV ...
The tritium proof-of-principle (TPOP) experiment was built by Oak Ridge National Laboratory (ORNL) to demonstrate the feasibility of forming solid tritium pellets and accelerating them to high velocities for fueling future fusion reactors. TPOP used a pneumatic pipe-gun with a 4-mm-i.d. by 1-m-long barrel. Nearly 1500 pellets were ...
The tritium proof-of-principle (TPOP) experiment was designed and built by Oak Ridge National Laboratory (ORNL) to demonstrate the formation and acceleration of the world's first tritium pellets for fueling of future fusion reactors. The experiment was first used to produce hydrogen and deuterium pellets ...
The tritium proof-of-principle (TPOP) experiment was designed and built by Oak Ridge National Laboratory (ORNL) to demonstrate the formation and acceleration of the world's first tritium pellets for fueling of future fusion reactors. The experiment was first used to produce hydrogen and deuterium pellets at ORNL. ...
Generator and diode problems have reduced electron beam parameters for the proof-of-principle autoresonant collective ion acceleration experiment from 3 MeV, 30 kA, and 200 ns to 2.25 MeV, 15 kA, and 100 ns. This reduction limits acceleration of hydrogen ions to about 4 MeV, if present experimental plans are followed. The output ion ...
Transverse-to-longitudinal emittance exchange has promising applications in various advanced acceleration and light source concepts. A proof-of-principle experiment to demonstrate this phase space manipulation method is currently being planned at the Argonne Wakefield Accelerator. The experiment focuses on ...
Injection of solid tritium pellets is considered to be the most promising way of fueling fusion reactors. The Tritium Proof-of- Principle (TPOP) experiment has demonstrated the feasibility of forming and accelerating tritium pellets. This injector is based on the pneumatic pipe-gun concept, in which pellets are ...
Injection of solid tritium pellets is considered to be the most promising way of fueling fusion reactors. The Tritium Proof-of-Principle experiment has demonstrated the feasibility of forming and accelerating tritium pellets. This injector is based on the pneumatic pipe-gun concept, in which pellets are formed in situ in the barrel and ...
Transverse to longitudinal phase space manipulation hold great promises, e.g., as a potential technique for repartitioning the emittances of a beam. A proof-of-principle experiment to demonstrate the exchange of a low longitudinal emittance with a larger transverse emittance is in preparation at the Argonne Wakefield Accelerator using a {approx}12 MeV ...
This document describes the programs of the Office of Fusion Energy in magnetic confinement systems. The following topics are described: (1) policy, (2) magnetic fusion energy program, (3) physics proof-of-principle programs, (4) major scaling experiments...
This progress report describes results from the upgraded Tandem Mirror Experiment (TMX-U), which began in May 1982, following the completion and checkout of modifications to the TMX facility. These modifications allowed us to carry out proof-of-principle ...
This report presents the results of a series of proof-of-principle experiments on the use of infrared measurements to quantitatively determine the amount of plutonium in containers. Measurements were made both on electrically heated simulant and an actual...
The concept of a high-repetition-rate, high-average power ?-source is based on Compton backscattering from the relativistic electron beam inside a picosecond CO2 laser cavity. Proof-of-principle experiments combined with comput
The advantages of using photonic band gap structures in vacuum electron devices are discussed. Their excellent mode selective properties permit them to be used as overmoded interaction structures in microwave tubes for either high power (>10 MW) or extremely high frequency (>100 GHz) operation. Two proof-of-principle experiments recently conducted at ...
Recently there has been a great interest in laser-plasma accelerators as possible next-generation particle accelerators because of their potential for ultra high accelerating gradients and compact size compared with conventional accelerators. It is known that the laser pulse is capable of exciting a plasma wave ...
There has been a tremendous progress in our understanding of the use of relativistically propagating plasma waves for accelerating charged particles. Such plasma waves have been excited using photon as well as electron beams at many different laboratories around the world. Furthermore, these plasma waves are shown to accelerate electrons with prodigious ...
The MBE-4 proof-of-principle experiment uses an induction linac to accelerate four Cs+ beams from injection at 200 kV to almost 1MV. When completed in the summer of 1987 it will be 17.2 meters long and have 24 acceleration gaps and 6 diagnostic gaps. Careful tailoring of the accelerating ...
Laser-accelerated ion beams have the great advantage over conventional ion beams of retaining the sub-ps pulse duration of the drive-laser. Together with the high beam current of kA-MA this makes them unique probes that enable new classes of experiments. One example of this is ion transport and stopping in hot, dense plasmas, where several competing models ...
The possibility of developing gyrotron-powered electromagnetic wiggler free-electron laser (FEL) oscillators is of considerable interest for reducing the electron energy required for operation in the infrared spectrum. This memorandum considers the design of a 10.6 micrometer electromagnetic wiggler FEL experiment based on the University of California at Santa Barbara (UCSB) 6 ...
The Versatile Array of Neutron Detectors at Low Energy (VANDLE) is a new array of plastic scintillator bars being developed at the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory (ORNL). The modular design enables optimization of different configurations for particular experiments, such as (d,n) and beta-delayed neutron-decay ...
Advanced pneumatic-injector-based pellet fueling systems are under development at Oak Ridge National Laboratory (ORNL) for fueling magnetically confined plasmas. The general approach is that of producing and accelerating frozen hydrogen isotope pellets at speeds in the range from 1 to 2 km/s and higher. Recently, ORNL provided pneumatic-based pellet fueling systems for the ...
The possibility of developing gyrotron-powered electromagnetic wiggler free-electron laser (FEL) oscillators is of considerable interest for reducing the electron energy required for operation in the infrared spectrum. This paper considers the design of a 10.6 [mu]m electromagnetic wiggler FEL experiment based on the University of California at Santa Barbara (UCSB) 6 MeV ...
Activities are reported on MBE-4, the four-beam proof-of-principle ion induction linear accelerator with the capability of beam-current amplification. Mechanical aspects of MBE-4, quadrupole insulator performance, and pulsers are discussed. The computer c...
Any imperfections in a practical quantum key distribution (QKD) system may be exploited by an eavesdropper to collect information about the key without being discovered. We propose a modified photon-number-splitting attack scheme against QKD systems based on weak laser pulses taking advantage of possible multiphoton pulses. Proof-of-principle experiments ...
A novel tuner has been developed by the Omega-P company to achieve fast control of the accelerator RF cavity frequency. The tuner is based on the ferroelectric property which has a variable dielectric constant as function of applied voltage. Tests using a Brookhaven National Laboratory (BNL) 1.3 GHz electron gun cavity have been carried out for a proof-of-principle ...
The A0 photoinjector (A0PI) facility at Fermilab has an ongoing proof-of-principle experiment to demonstrate the exchange of the transverse horizontal and longitudinal emittances. This experiment relies on measurements of the transverse emittances and longitudinal emittance upstream and downstream of the exchanger beamline. At several ...
The problem of controlling the variations in the rf power system can be effectively cast as an application of modern control theory. Two components of this theory are obtaining a model and a feedback structure. The model inaccuracies influence the choice of a particular controller structure. Because of the modeling uncertainty, one has to design either a variable, adaptive controller or a fixed, ...
In the development of the radio-frequency quadrupole (RFQ) linac, the resonator cavity's mechanical design may be a challenge similar in magnitude to that of the development of the accelerator structure itself. Experience with the all-copper 425-MHz RFQ proof-of-principle linac has demonstrated that the resonator cavity must ...
The TFTR tritium pellet injector (TPI) is designed to provide a tritium pellet fueling capability with pellet speeds in the 1{minus} to 3 km/s-range for the TFTR D-T phase. The existing TFTR deuterium pellet injector is being modified at Oak Ridge National Laboratory to provide a fourshot, tritium-compatible, pipe-gun configuration with three upgraded single-stage pneumatic guns a two -stage light ...
A university-scale concept exploration experiment is proposed to investigate the improved confinement properties of the quasi-toroidal stellarator. The experiment would investigate three issues germane to a larger proof-of-principle experiment: first, the improved neoclassical confinement through measurement of the ...
An RF deflecting structure has been designed and fabricated for a transverse-to-longitudinal emittance exchange experiment at Argonne National Laboratory (ANL) [Y.-E. Sun, et al., Design study of a transverse-to-longitudinal emittance exchange proof-of-principle experiment, in: Proceedings of PAC-2007, Albuquerque, NM, USA, 2007, pp. ...
The rapid progress in the field of laser particle acceleration has stimulated a debate about the promising perspectives of laser based ion beam sources. For a long time, the beams produced exhibited quasi-thermal spectra. Recent proof-of-principle experiments demonstrated that ion beams with narrow energy distribution can be generated ...
In the x-ray wavelengths, the two leading FEL concepts are the self-amplied spontaneous emission (SASE) conguration and the high-gain harmonic generation (HGHG) scheme. While the radiation from a SASE FEL is coherent transversely, it typically has rather limited temporal coherence. Alternatively, the HGHG scheme allows generation of fully coherent radiation by up-converting the frequency of a ...
In the x-ray wavelengths, the two leading FEL concepts are the self-amplified spontaneous emission (SASE) configuration and the high-gain harmonic generation (HGHG) scheme. While the radiation from a SASE FEL is coherent transversely, it typically has rather limited temporal coherence. Alternatively, the HGHG scheme allows generation of fully coherent radiation by up-converting the frequency of a ...
An analysis was performed to determine the best multilayer combination for initial experiments, consistent with available electron beam sources. A study was also performed as to the allowable tolerances for thickness variations of the multilayer. It was f...
... Proof-of-Principle Polymer Engine-Generator, to the Army Research Office (ARO) and Defense Advanced Research Projects Agency (DARPA). ...
DTIC Science & Technology
This document describes the programs of the Office of Fusion Energy in magnetic confinement systems. The following topics are described: (1) policy, (2) magnetic fusion energy program, (3) physics proof-of-principle programs, (4) major scaling experiments, (5) energy producing experimental reactors: design studies and long lead time technology development, ...
Two proof-of-principle experiments toward T 1-limited magnetic resonance imaging with NV centers in diamond are demonstrated. First, a large number of Rabi oscillations is measured and it is demonstrated that the hyperfine interaction due to the NV's 14N can be extracted from the beating oscillations. Second, the Rabi beats under V-type microwave ...
The body of this paper discusses the theory and some rules for designing a multistage Binary Energy Compressor (BEC) including its response to nonstandard phase coding, describes some proof-of-principle experiments with a couple of low power BECs, presents the design parameters for some sample linear collider rf systems that could possibly use a BEC to ...
We demonstrate the first electronically switchable Bragg structure for THz frequencies. The structure works as stop-band filter and as mirror. It exhibits the 60 GHz broad stop-band around 300 GHz which can be removed by reorienting liquid crystal molecules in an external electric field. Our first proof-of-principle experiments agree very well with ...
PubMed
breakup via filamentation on mm scale: Laser-induced breakup of a water jet: (J. Lettry, CERN) R. Samulyak. 1234 Syringe PumpSecondary Containment Jet Chamber Proton Beam Solenoid #12;K. McDonald MUTAC Review April of the experiment already provides proof-of-principle of a free mercury jet target for megawatt proton beams
E-print Network
Hexagonal micro-pillar cavities: multimode resonances and open-loop resonance linewidth broadening report our proof-of-principle experiment and modeling of hexagonal micro-pillar (�-pillar) cavities. A commercial hexagonal silica fiber (125�m plane-to-plane) was side-coupled perpendicularly with a Gaussian
Proof-of-principle experiments are reported for a new concept in electrically rechargeable zinc-air battery. The zinc electrode is a porous flow-thru type using a copper foam metal substrate with zinc deposition onto the foam metal from concentrated zinca...
A preliminary point design configuration has been developed, based on conceptual considerations. The PHIBEX design specifications are outlined. The principal parameters are, major radius 57 cm; minor radius 22 cm; toroidal field 15.75T; plasma current of ...
Activities are reported on MBE-4, the four-beam proof-of-principle ion induction linear accelerator with the capability of beam-current amplification. Mechanical aspects of MBE-4, quadrupole insulator performance, and pulsers are discussed. The computer code, SLID, has been used to help understand the longitudinal beam dynamics in MBE-4. A ...
The development of pellet injectors for plasma fueling of magnetic confinement fusion experiments has been under way at Oak Ridge National Laboratory (ORNL) for the past 15 years. Recently, ORNL provided a tritium-compatible four-shot pneumatic injector for the Tokamak Fusion Test Reactor (TFTR) based on the in situ condensation technique that features three single-stage gas ...
Several advanced plasma fueling systems are under development at the Oak Ridge National Laboratory (ORNL) for present and future magnetic confinement devices. These include multishot and repeating pneumatic pellet injectors, centrifuge accelerators, electrothermal guns, a Tritium Proof-of-Principle experiment, and an ultrahigh velocity ...
We report the first experimental observation of quantum Talbot effects with single photons and entangled photon pairs. Both the first- and second-order quantum Talbot self-images are observed experimentally. They exhibit unique properties, which are different from those produced by coherent and incoherent classical light sources. In particular, our experiments show that the ...
://www.bnl.gov/csc/projects/High Energy/Muon Collider/ [6] J. Lettry et al., Thermal shocks and magnetohydrodynamics in high power mercuryA PROOF-OF-PRINCIPLE EXPERIMENT FOR A HIGH-POWER TARGET SYSTEM H.G Kirk , R. Samulyak, N. Simos, T of the generated low-P pions in a high-field ( 15 T) solenoidal magnet, as shown in Fig. 1. An important byproduct
A conceptual design of a muon acceleration scheme based on recirculating superconducting linacs is proposed. In the presented scenario, acceleration starts after ionization cooling at 210 MeV/c and proceeds to 20 GeV, where the beam is injected into a neutrino factory storage ring. The key technical issues are addressed, such as the choice of ...
A conceptual design of a muon acceleration based on recirculating superconducting linacs is proposed. In the presented scenario, acceleration starts after ionization cooling at 210 MeV/c and proceeds to 20 GeV, where the beam is injected into a neutrino factory storage ring. The key technical issues are addressed; such as: the choice of ...
The NSTX (National Spherical Torus Experiment) facility located at Princeton Plasma Physics Laboratory is the newest national fusion science experimental facility for the restructured US Fusion Energy Science Program. The NSTX project was approved in FY 97 as the first proof-of-principle national fusion facility dedicated to the spherical torus research. ...
A scheme of generating a uniform ellipsoidal laser pulse for high-brightness photoinjectors is discussed. The scheme is based on the chromatic aberration of a dispersive lens. Fourier optics simulation reveals the interplay of group velocity delay and dispersion in the scheme, as well as diffractions. Particle tracking simulation shows that the beam generated by such a laser pulse approaches the ...
We report to the best of our knowledge on the first proof-of-principle experiment demonstrating high average power (10 W) optical demodulation of a fiber amplified phase-modulated single frequency signal with a sideband suppression of more than 30 dB. The single frequency signal is delivered by an external cavity diode laser with a bandwidth of <100 kHz ...
?-Pyrones and pyrimidones are common structural motifs in natural products and bioactive compounds. They also display photochemistry that generates high-energy intermediates that may be capable of protein reactivity. A library of pyrones and pyrimidones was synthesized, and their potential to act as photoaffinity probes for nondirected affinity-based protein profiling in several crude cell lysates ...
Proof-of-principle experiments have demonstrated an electrostatic field evaporation based deuterium ion source for use in compact, high-output deuterium-tritium neutron generators. The ion source produces principally atomic deuterium and titanium ions. More than 100 ML of deuterated titanium thin film can be removed and ionized from a single tip in less ...
In this paper we describe the technical design of an ongoing proof-of-principle echo-enabled harmonic generation (EEHG) experiment at the Next Linear Collider Test Accelerator (NLCTA) at SLAC.We present the design considerations and the technical details of the experiment. Recently a new method, entitled ...
Clinical Trials are under way to evaluate agents labeled with the nuclide {sup 225}Ac and its decay product {sup 213}Bi, in targeted alpha-immuno-therapy. {sup 225}Ac can be produced on a medium-energy cyclotron via the nuclear reaction {sup 226}Ra(p,n){sup 225}Ac. To demonstrate proof-of-principle, a vintage AEG cyclotron, Model E33, with an internal target, had been employed ...
Clinical Trials are under way to evaluate agents labeled with the nuclide 225Ac and its decay product 213Bi, in targeted alpha-immuno-therapy [1]. 225Ac can be produced on a medium-energy cyclotron via the nuclear reaction 226Ra(p,n)225Ac. To demonstrate proof-of-principle, a vintage AEG cyclotron, Model E33 [2], with an internal target, had been employed in a pilot production ...
We present a research program to evaluate fast ignition (FI) lit by laser-driven ion beams heavier than protons. Compared to protons, heavier ions have the potential advantage of a more localized energy deposition, which might translate into a significantly lower total beam-energy requirement. The starting points for this research are the target-design requirements in the study by Temporal et al. ...
Opening switch research at the University of New Mexico (UNM) is directed toward moderate-current (--10 kA) devices with potential applications to high-power charged particle accelerators. Two devices with the capacity for controlling gigawatt high-voltage circuits, the grid-controlled plasma flow switch and the scanned-beam switch, are under investigation. Both switches are ...
This interim report summarizes results from the Tandem Mirror Experiment (TMX) during the period January to July 1980 and describes the physics experiments, the machine operation, and the diagnostics that were added to TMX during this period. This operating period followed the initial proof-of-principle TMX ...
Gene therapy of muscular dystrophy requires systemic gene delivery to all muscles in the body. Adeno-associated viral (AAV) vectors have been shown to lead to body-wide muscle transduction after a single intravascular injection. Proof-of-principle has been demonstrated in mouse models of Duchenne muscular dystrophy and limb girdle muscular dystrophy. Before initiating clinical ...
PubMed Central
The LANSCE (Los Alamos Neutron Science Center) control system upgrade program continues with the impending replacement of the RICE (Remote Instrumentation and Control Equipment) subsystem. The RICE subsystem upgrade is a challenge because of its technology (late 1960s), number of channels (>10,000), and unique characteristics (all-modules data takes, timed/flavored data takes). The plan is ...
The success of the radio-frequency quadrupole (RFQ) proof-of-principle (POP) tests conducted in 1980 at Los Alamos have essentially guaranteed that the RFQ linac will be used in many accelerator projects soon. Several RFQs are already under construction at Los Alamos, and we expect to be designing and machining the vanes for several RFQs to be built at ...
1.7 x 10{sup 8} x-ray photons per 3.5 ps pulse have been produced in Thomson scattering by focusing CO{sub 2} laser pulse on counter-propagating relativistic electron beam. We explore a possibility of further enhancement of process efficiency by propagating both beams in a plasma capillary. Conventional synchrotron light sources based on using giga-electron-volt electron synchrotron ...
This paper is concerned with the stability of carbon fiber sail structures that are being studied in a series of experiments at the Jet Propulsion Laboratory (JPL) by a team led by Microwave Sciences, Inc. The passive dynamic stability in the one-dimensional (1-D) case is most easily understood in terms of the fixed points of the trajectories for the governing equations of ...
This paper describes the preparation and evaluation of molecularly imprinted polymers (MIPs) that display specificity toward diisopropyl methylphosphonate (DIMP) and tributyl phosphate (TBP). Polymer activity was assessed by solid-phase extraction and high-performance liquid chromatography experiments. Both DIMP- and TBP-specific MIPs selectively retained their targets ...
The PEANUT experiment was designed to study the NuMi neutrino beam at Fermilab. The detector uses a hybrid technique, being made of nuclear emulsions and scintillator trackers. Emulsion films act as a micrometric tracking device and are interleaved with lead plates used as passive material. The detector is designed to precisely reconstruct the topology of neutrino interactions ...
New experiments being considered for the 1 MA, 100-250 ns Cornell University COBRA pulser involve gas puff z-pinches. We are presently conducting proof-of-principle tests on diagnostics and hardware for these experiments. One of the requirements for these studies is the measurement of neutral density profiles of the injected gas puffs. ...
Proof-of-principle experiments on the suitability of electron cyclotron current drive (ECCD) for active current profile control are reported. Experiments with second harmonic extraordinary mode absorption at power levels near 1 MW have demonstrated ability to modify the current profile. This modification is manifested in changes in the ...
A series of practice winding experiments were done during the winding of the development magnets for ELMO Bumpy Torus Proof-of-Principle (EBT-P - a large, experimental fusion device using 36 superconducting mirror magnets). The experimental method involved layer winding conductor on the bobbin and monitoring the hoop strain accumulation on the inside of ...
Recent experimental laser isotope separation results obtained using the methods of single- and multiple-photon dissociation and laser-induced chemical reactions employing a single laser are reviewed. Also discussed are recent experiments on several- and multiple-photon methods that employed more than one laser wavelength. For each of these processes, methods are given for ...
We report the first proof-of-principle experiment of iterative phase retrieval from magnetic x-ray diffraction. By using the resonant x-ray excitation process and coherent x-ray scattering, we show that linearly polarized soft x rays can be used to image both the amplitude and the phase of magnetic domain structures. We recovered the magnetic structure of ...
The purpose of the ALPS program is to identify and evaluate advanced limiter/diverter systems that will enhance the attractiveness of fusion power. The highest priority goals at present are achieving high power density, up to 50 MW/m{sup 2}, and showing compatibility of plasma-facing surfaces with plasma operation. Personnel representing a wide range of disciplines from a number of institutions ...
With the advent of high average power FELs, the idea of using such a device to produce x-rays via the Thomson scattering process is appealing, if sufficient flux and/or brightness can be generated. Such x-rays are produced simultaneously with FEL light, offering unprecedented opportunities for pump-probe studies. We discuss non-invasive modifications to the Jefferson Lab's FEL that would ...
We propose a novel reconfigurable time domain spectral phase encoding (SPE) scheme for coherent optical code-division-multiple-access application. In the proposed scheme, the ultra-short optical pulse is stretched by dispersive device and the SPE is done in time domain using high speed phase modulator. The time domain SPE scheme is robust to wavelength drift of the light source and is very ...
In this article the usefulness of the enzyme phi29 DNA polymerase and the principle of rolling circle amplification (RCA) for creating single-stranded DNA (ssDNA) nanostructures is described. Currently we are working on the spatial orientation of a growing ssDNA molecule during its RCA-based synthesis by the application of a hydrodynamic force. Starting at an immobilized primer at single molecule ...
A remote atmospheric breakdown is a very rich source of UV and broadband visible light that could provide an early warning of the presence of chemical-biological warfare agents at extended standoff distances. A negatively chirped laser pulse propagating in air compresses in time and focuses transversely, which results in a rapid laser intensity increase and ionization near the focal region that ...
There is considerable interest in the use of muon beams to create either an intense source of decay neutrinos aimed at a detector located 3000-7500 km away (a Neutrino Factory), or a Muon Collider that produces high-luminosity collisions at the energy frontier. R&D aimed at producing these facilities has been under way for more than 10 years. This paper will review experimental results ...
Quantum cryptography has been shown to be an effective technique for the secure distribution of cryptographic keys on point-to-point communication links. Here, we describe adaptations of the existing quantum cryptography protocols and equipment configurations that allow secure key distribution to be performed on a variety of multiuser passive optical network (PON) architectures. These adaptations ...
A 36-month program to study the linear relativistic electron beam-plasma interaction is proposed. This program is part of a joint proposal between the Physics International Company (PI) and Los Alamos Scientific Laboratory (LASL) that combines the advanced electron beam generator technology at PI with the highly developed computer simulation technology at LASL. The proposed LASL program includes ...
Up to now, the term "transport-optimized" stellarators has meant optimized to minimize neoclassical transport, while the task of also mitigating turbulent transport, usually the dominant transport channel in such designs, has not been addressed, due to the complexity of plasma turbulence in stellarators. Here, we demonstrate that stellarators can also be designed to mitigate their turbulent ...
Efficient initiation of large-volume chemical lasers may be achieved by neutron induced reactions which produce charged particles in the final state. When a burst mode nuclear reactor is used as the neutron source, both a sufficiently intense neutron flux and a sufficient short initiation pulse may be possible. Proof-of-principle experiments are planned to ...
Efficient initiation of large-volume chemical lasers may be achieved by neutron induced reactions which produce charged particles in the final state. When a burst mode nuclear reactor is used as the neutron source, both a sufficiently intense neutron flux and a sufficiently short initiation pulse may be possible. Proof-of-principle experiments are planned ...
DNA repeat expansions can result in the production of toxic RNA. RNA toxicity has been best characterised in the context of myotonic dystrophy. Nearly 20 mouse models have contributed significant and complementary insights into specific aspects of this novel disease mechanism. These models provide a unique resource to test pharmacological, anti-sense, and gene-therapy therapeutic strategies that ...
We present proof-of-principle experiments and simulations that demonstrate a new biological assay technology in which microscopic tags carrying multi-bit magnetic codes are used to label probe biomolecules. It is demonstrated that these 'micro-barcode tags' can be encoded, transported using micro-fluidics and are compatible with surface chemistry. We also ...
We have demonstrated the coherence filtering operation for optical low-coherence reflectometry via degenerate four-wave mixing (DFWM) in a thin nonlinear optical layer. To perform proof-of-principle DFWM experiments, we use a thin dye solution with a thermally-induced optical nonlinearity. In contrast to previous works, which used c.w. light-emitting ...
The new NHMFL 60T quasi-continuous magnet produces a flat-top field for a period of 100 ms at 60 Tesla, and for longer time at lower fields, e.g. 0.5 s at 45 Tesla. We have developed for the first time the capability to measure heat capacity at very high magnetic fields in the NHMFL 60T quasi-continuous magnet at LANL, using a probe built out of various plastic materials. The field plateau allows ...
The linear magnetic trap is an attractive concept both for fusion reactors and for other plasma applications due to its relative engineering simplicity and high-beta operation. Applying the α- channeling technique to linear traps, such as mirror machines, can benefit this concept by efficiently redirecting α particle energy to fuel ion heating or by otherwise sustaining plasma confinement, thus ...
The linear magnetic trap is an attractive concept both for fusion reactors and for other plasma applications due to its relative engineering simplicity and high-beta operation. Applying the ?- channeling technique to linear traps, such as mirror machines, can benefit this concept by efficiently redirecting ? particle energy to fuel ion heating or by otherwise sustaining plasma confinement, thus ...
Functional gene analysis in vivo represents still a major challenge in biomedical research. Here we present a new method for the efficient introduction of nucleic acids into the postnatal mouse forebrain. We show that intraventricular injection of DNA followed by electroporation induces strong expression of transgenes in radial glia, neuronal precursors and neurons of the olfactory system. We ...
Pulse power systems delivering in excess of 100 MJ represent one of the next major challenges to the pulse power community. While a laboratory pulse power system in this energy range if feasible, it represents a very substantial investment of both time and resources. Prudence requires that fundamental proof-of-principle for the contemplated application is established before ...
A novel technique for studying photon propagation in scattering media is proposed and demonstrated, as is believed, for the first time. Photons propagating through the medium, from a frequency-ramped single-mode diode laser, meet a reference beam from the same source, at a common detector, and beat frequencies corresponding to various temporal delays are observed by heterodyne techniques. Fourier ...
Several comprehensive studies of radio frequency (rf) breakdown and rf heating are reported. They are of general interest to magnetic confinement fusion, rf linac, and high power microwave source development. The major results include: (1) a ground-breaking theory of multipactor discharge on dielectric, including a successful proof-of-principle experiment ...
An advanced concept proof-of-principle demonstration was successfully performed to show the feasibility of a practical switchable radioactive neutron source (SRNS) that can be switched on and off like an accelerator, but without requiring accelerator equipment such as high voltage supply, control unit, etc. This source concept would ...
A new concept for a CDS has been developed under a Phase I ARPA funded program; it uses gamma resonance absorption (GRA) to detect certain illegal drugs that may be transported in man-portable containers. A high detection probability for heroin and cocaine is possible with a device that is also searching for explosives. Elemental detection of both N and Cl is utilized, and with tomography, a 3D ...
During the last few years we have been experimentally exploring the possibilities of manipulating neutral polar molecules with electric fields [1]. Arrays of time-varying, inhomogeneous electric fields have been used to reduce in a stepwise fashion the forward velocity of molecules in a beam. With this so-called 'Stark-decelerator', the equivalent of a LINear ACcelerator ...
An overview of the Idaho National Engineering Laboratory (INEL) Slagging Pyrolysis Incinerator (SPI) Proof-of-Principle Test Series is presented. The Andco-Torrax SPI process is described and related to processing transuranic-contaminated waste stored at the INEL. Major waste constituents which can impact the feasibility of using the SPI for processing the INEL TRU waste are ...
Hydrogen pellets are successfully accelerated for the first time using a two-stage system consisting of a pneumatic gun and an electromagnetic railgun. The pneumatic gun preaccelerator forms cylindrical hydrogen ice pellets (1.6-mm diam x 2.15-mm long) and accelerates them with high-pressure helium gas to velocities in excess of 500 m/s. The booster ...
This report describes work carried out on DOE contract number DE-AC02-80ER10569 during the period December 15, 1979 to May 31, 1992. The original purpose of this research was to investigate the use of slow space charge waves on weakly relativistic electron beams for ion acceleration. The work had three major objectives: development of a suitable ion injector, growth and study ...
... Title : Transition Radiation Generated by MeV Electrons in a Multilayer Solid Target as an X-Ray Source for Medical Applications: Proof-Of-Principle ...
... During this time frame, Sandia National Laboratories was tasked to develop a Phase 1 proof-of- principle system consisting of readily available ...
... potential for improved efficiency in power ... during compression in a motored reciprocating compressor. ... The observed results indicate the feasibility ...
... and its programs, visit www.nih.gov . Reference: AR Kreimer, et al. Proof-of-Principle Evaluation of ...
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Sophisticated signal processing techniques and simple proof-of-principle antenna arrays built from PVC pipe, aluminum foil and copper wire could ...
NASA Website
Pacific Northwest National Laboratory (PNNL) conducted a proof-of-principle test at the Fort Lewis Logistics Center to determine the feasibility of using the In Situ Redox Manipulation (ISRM) technology for remediating groundwater contaminated with dissolved trichloroethylene (TCE). ISRM creates a permeable treatment zone in the subsurface to remediate redox-sensitive contaminants in groundwater. ...
BackgroundVertebrate bloodfeeding is a critical component of a mosquito's ability to transmit pathogens that cause diseases such as malaria, dengue fever and viral encephalitis. Due to degradation by the digestive process, current methods to identify mosquito bloodmeal sources are only useful for approximately 36 hours post-feeding. A critical need exists for technologies to extend this window and ...
The proof-of-principle HGHG experiment at 5 {mu} [1, 2] and recent HGHG experiment at DUVFEL [3] have generated significant interests in the FEL community. The more relaxed requirement on electron beam current and emittance to generate coherent deep UV output with much narrower bandwidth and high pulse energy stability, as exhibited by the recent ...
This report presents the results of proof-of-principle experiments for using electrostatic curtains (ESCs) as a transuranic (TRU) contamination control technique. The TRU contaminants controlled included small (micron to submicron) particles of plutonium and americium compounds associated with defense related waste. A series of four experiments were ...
The pathology of many of the world's most important infectious diseases is caused by the immune response. Additionally age-related disease is often attributed to inflammatory responses. Consequently a reduction in infections and hence inflammation early in life has been hypothesized to explain the rise in lifespan in industrialized societies. Here we demonstrate experimentally for the first time ...
An applied-magnetic-field diode (ABD) has been designed and fielded to perform proof-of-principle experiments for ion-beam transport relevant to inertial confinement fusion. The ABD is a 2-coil, annular flux-excluding design, with a 10.5-cm outer radius. The goal is to produce 150-200 kA of protons at 1.5 MeV, focused on axis at 70 cm for self-pinch ...
A method of scoring a ground-based neutral particle beam pointing experiment is described. Beam scoring in this context means performing beam direction measurements in the near field (tens of meters) sufficient to determine whether energy would be concentrated on a far-field target as desired in a pointing experiment. The principle of operation is to ...
Owing to increased needs for positron emission tomography (PET), high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their ...
The goal of this laboratory-directed research and development (LDRD) project was to develop a new and efficient electronic structure algorithm that would scale linearly with system size. Since the start of the program this field has received much attention in the literature as well as in terms of focused symposia and at least one dedicated international workshop. The major success of this program ...
The purposes of Argonne`s Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory`s R&D capabilities, and further the development of its strategic initiatives. Among the aims of the projects supported by the Program are establishment of engineering ``proof-of-principle``; development of an ...
The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory's R D capabilities, and further the development of its strategic initiatives. Among the aims of the projects supported by the Program are establishment of engineering ...
This report presents the results of the airtesting portion of the proof-of-principle testing of a Control Rod Scram Deceleration Device developed for use in the Gas Cooled Fast Reactor (GCFR). The device utilizes a grooved flywheel to decelerate the translating assembly (T/A). Two cam followers on the translating assembly travel in the flywheel grooves and transfer the energy of the T/A to the ...
Objective of Phase 3 is to complete proof-of-principle testing in full-scale systems of the dual cure photocatalyst technology developed in earlier phases. Phase 3 commercial applications are aerospace topcoats, aerospace primers, and solventless manufacture of tape backings. Progress was made in improving urethane/acrylate formulation for aerospace topcoats, particularly in ...
Section 2904(h) of Title 10, United States Code, requires that an annual report of the Strategic Environmental Research and Development Program (SERDP) Scientific Advisory Board (SAB) be submitted to Congress no later than March 15 of each year. The Annual Report is required to describe the actions of the SAB during the preceding year and to provide any recommendations, including recommendations ...
This workshop was caged because of the growing perception in the FEL source community that recent advances have made it possible to extend FEL operation to wavelengths about two orders of magnitude shorter than the 240 nm that has been achieved to date. In addition short wavelength FELs offer the possibilities of extremely high peak power (several gigawatts) and very short pulses (of the order of ...
In fusion, there are two possible direct energy conversion methods: plasma direct energy conversion (PDC), which recovers the plasma energy leaking out of the confined region, and beam direct energy conversion (BDC), which recovers the unneutralized energetic ion energy in a neutral beam injection (NBI) system used for plasma heating and to sustain current. In the very powerful near-term NBI ...
In our previous work, the first proof-of-principle experiments were successfully conducted on the particle control capability based on the concept of moving-surface plasma-facing component (MS-PFC). Over a continuously titanium-gettered rotating drum, hydrogen recycling was found to be reduced down to levels around 94% even at steady state. These ...
The high spatial and temporal resolution of a neutron counting detector using microchannel plates (MCPs) combined with Medipix2/Timepix readout can substantially improve the spatial resolution of neutron transmission spectroscopy, as shown in our proof-of-principle experiments. Provided that the neutron fluence and data acquisition time are sufficient, ...
We have confirmed the overall hydrodynamic scheme for cone-focussed FI via two series of scaled, indirect-drive implosion experiments on Omega, and we report our continued analysis of the results. New designs will test the hydro in direct-drive. This concept's usefullness requires efficient transport, via hot electrons, of energy deposited by the short-pulse laser to high ...
A generic DNA microarray design applicable to any species would greatly benefit comparative genomics. We have addressed the feasibility of such a design by leveraging the great feature densities and relatively unbiased nature of genomic tiling microarrays. Specifically, we first divided each Homo sapiens Refseq-derived gene's spliced nucleotide sequence into all of its possible contiguous 25?nt ...
Coherent electron cooling (CEC) has a potential to significantly boost luminosity of high-energy, high-intensity hadron-hadron and electron-hadron colliders*. In a CEC system, a hadron beam interacts with a cooling electron beam. A perturbation of the electron density caused by ions is amplified and fed back to the ions to reduce the energy spread and the emittance of the ion beam. To demonstrate ...
Physics and systems design analyses are carried out to estimate the desired fusion core parameters for an ST based Volume Neutron Source (ST-VNS) that utilizes a single-turn toroidal field coil (TFC). A design with a major radius R, = 1.07 m is estimated to have large margins in physics, technology, and engineering for the initial operation at moderate performance (neutron wall load, W, = 0.5-2.0 ...
Oak Ridge National Laboratory has been developing pellet injectors for plasma fueling experiments on magnetic confinement devices for more than 15 years. Recent major applications of the ORNL development program include (1) a tritium-compatible four-shot pneumatic injector for the Tokamak Fusion Test Reactor, (2) a centrifuge pellet injector for the Tore Supra tokamak, and ...
Time-delayed feedback control (TDFC) is transferred to the optical domain and applied to complex multisection semiconductor lasers as used in optical communication. Pyragas-type control is provided by purely optical feedback from an external Fabry-P�rot interferometer. This all-optical setup needs no time-consuming signal processing and, thus, has practically no speed limit. ...
Electron Cyclotron Current Drive (ECCD) is considered a leading candidate for current profile control in Advanced Tokamak (AT) operation. Localized ECCD has been clearly demonstrated in recent proof-of-principle experiments on DIII-D. The measured ECCD efficiency near the magnetic axis agrees well with standard theoretical predictions. However, for ...
Entanglement is a necessary resource for quantum applications--entanglement established between quantum systems at different locations enables private communication and quantum teleportation, and facilitates quantum information processing. Distributed entanglement is established by preparing an entangled pair of quantum particles in one location, and transporting one member of the pair to another ...
Quantum teleportation is central to the practical realization of quantum communication. Although the first proof-of-principle demonstration was reported in 1997 by the Innsbruck and Rome groups, long-distance teleportation has so far only been realized in fibre with lengths of hundreds of metres. An optical free-space link is highly desirable for extending the transfer ...
Off-axis electron Bernstein wave current drive (EBWCD) may be critical for sustaining noninductive high-beta National Spherical Torus Experiment (NSTX) plasmas. Numerical modeling results predict that the {approx}100 kA of off-axis current needed to stabilize a solenoid-free high-beta NSTX plasma could be generated via Ohkawa current drive with 3 MW of 28 GHz EBW power. In ...
DNA and histone modifications direct the functional state of chromatin and thereby the readout of the genome. Candidate approaches and histone peptide affinity purification experiments have identified several proteins that bind to chromatin marks. However, the complement of factors that is recruited by individual and combinations of DNA and histone modifications has not yet ...
Several of the underground storage tanks currently used to store waste at Hanford have been placed on the Flammable Gas Watch List, because the waste is either known or suspected to generate, store, and episodically release flammable gases. The objective of this experimental study is to develop a method to measure gas bubble retention in simulated tank waste and in diluted simulant. The method and ...
Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and ...
Spherical tokamaks, with their relatively low toroidal field, extend fast-ion-driven instability physics to parameter ranges not normally accessed in conventional tokamaks. The low field means that both the fast-ion Larmor radius normalized to the plasma minor radius and the ratio of the fast-ion velocity to the Alfven speed are relatively large. The large Larmor radius of the ions enhances their ...
The plasma generating parts of ion sources including their power supplies are usually floated to high potential (ion extraction voltage), thus requiring great insulation efforts and high costs for high-energy ion beams. A new concept for pulsed ion sources is presented in which a single power supply is used to simultaneously produce the plasma and high extractor voltage via a modified Marx ...
We present white light generation controlled and tuned by multi-color quantum-dot-quantum-well emitters made of onion-like CdSe/ZnS/CdSe core/shell/shell heteronanocrystals integrated on InGaN/GaN light-emitting diodes (LEDs). We demonstrate hybrid white LEDs with (x, y) tristimulus coordinates tuned from (0.26, 0.33) to (0.37, 0.36) and correlated color temperatures from 27 413 to 4192 K by ...
As Fusion programs progress from proof-of-principle experiments toward practical fusion power reactors, parallel programs are needed to develop components capable of withstanding the extreme surface heat and particle fluxes that will be encountered. The separation of the surface physics and heat flux effects appears to be a quick and economical route to ...
We report a simple method of creating terahertz waves by applying the photo-Dember effect in a (100)-oriented InAs film coated onto the 45-degree wedged-end facet of an optical fiber. The terahertz waves are generated by infrared pulses guided through the optical fiber which is nearly in contact with a sample and then measured by a conventional photo-conductive antenna detector. Using this ...
Some gynaecological cancers are uncommon, such as sex cord-stromal tumours, malignant germ-cell tumours, vulvar carcinoma, melanoma of the female genital tract, clear-cell carcinoma of the ovary and endometrium, neuroendocrine tumours of the cervix, and gestational trophoblastic neoplasia. All these cancers have different clinicopathological characteristics, suggesting different molecular ...
The isotope dilution gamma-ray spectrometry (IDGS) technique has been demonstrated for simultaneously measuring concentrations and isotopic compositions of plutonium in spent-fuel input dissolver solutions. For timely analyzing nuclear materials on the purpose of material accountancy and quality control/assurance, we have performed a feasibility study to implement the IDGS for measuring mixed ...
Quantum control of strong interactions between a single atom and photon has been achieved within the setting of cavity quantum electrodynamics (cQED). To move beyond proof-of-principle experiments involving one or two conventional optical cavities to more complex scalable systems that employ N > 1 microscopic resonators requires localization of atoms on ...
A new type of high-resolution X-ray imaging crystal spectrometer is being developed to measure ion and electron temperature profiles in tokamak plasmas. The instrument is particularly valuable for diagnosing plasmas with purely Ohmic heating and rf heating, since it does not require the injection of a neutral beam - although it can also be used for the diagnosis of neutral-beam heated plasmas. The ...
Optical technologies have changed the way people live since centuries, and the pace of knowledge creation and implementation has strongly increased in the recent past. Prominent examples of recent change include the speed with which information can be exchanged, allowing delay-free intercontinental communication, and the advent of the broadband internet. The conception of planar waveguide optics ...
SummaryThe availability of noninvasive prenatal diagnosis for the fetal RhD status (NIPD RhD) is an obvious benefit for alloimmunized pregnant women. This review gives information about the performance characteristics of current diagnostic technologies and recent promising proof-of-principle studies. Notably, during the past 3 years almost twice as much samples have been ...
DNA stretching in nanofluidic channels that are round 100 nm in diameter and 100's of microns long is an emerging technique for the genetic analysis of long nucleic acid molecules. We will explain why nanofluidic stretching differs from other single-molecule techniques, in particular how the ability to measure individuality is greatly enhanced by the fundamentally different averaging properties. ...
The development of time-reversal (T/R) communication systems is a recent signal processing research area dominated by applying T/R techniques to communicate in hostile environments. The fundamental concept is based on time-reversing the impulse response or Green's function characterizing the uncertain communications channel to mitigate deleterious dispersion and multipath effects. In this paper, ...
Spatially resolved measurements of electric fields at electrochemical interfaces would be a critical step toward further understanding and modeling the detailed structure of electric double layers. The goal of this project was to perform proof-of-principle experiments to demonstrate the use of field-sensitive dyes for optical measurements of fields in ...
Raman spectroscopy has been explored for various biomedical applications (e.g., cancer diagnosis) because it can provide detailed information on the chemical composition of cells and tissues. For imaging applications, several variations of Raman spectroscopy have been developed to enhance its sensitivity. To date, a wide variety of molecular targets and biological events have been investigated ...
The elemental characterization of materials constituting radioactive waste is of great importance for the management of storage and repository facilities. To complement the information brought by gamma or X-ray imaging, the performance of a fast neutron interrogation system based on the associated particle technique (APT) has been investigated by using MCNP simulations and by performing ...
The Robotic All Terrain Lunar Exploration Rover (RATLER) design concept began at Sandia National Laboratories in late 1991 with a series of small, proof-of-principle, working scale models. The models proved the viability of the concept for high mobility through mechanical simplicity, and eventually received internal funding at Sandia National Laboratories for full scale, ...
develop technology for fuels, cladding, fuel elements, control elements, structural materials, and materials for other applications extend from base technology through proof-of-principle. More specifically, the Fuels and Materials Element outlines programs designed to: (1) Determine in- and out-of- reactor properties of materials, with emphasis on the effect of LMFBR ...
A beam profile monitor for H{sup -} beams using laser photoneutralization is being developed at Brookhaven National Laboratory [1] for use on the Spallation Neutron Source (SNS) [2]. An H{sup -} ion has a first ionization potential of 0.75eV and can be neutralized by light from a Nd:YAG laser ({lambda}=1064nm). To measure beam profiles, a narrow laser beam is passed through the ion beam ...
We present evidence of Ionospheric Current Drive (ICD) by modulated F-region ionospheric HF heating, using the HAARP Ionospheric Research Instrument (IRI). The ICD is different from the conventional low frequency electrojet modulation in that it does not require the presence of ambient currents. The ICD is an oscillatory diamagnetic current driven by the heater created local pressure gradients. ...
To extract the effective neutrino Majorana mass from an observed 0??? decay, precise knowledge of the involved nuclear matrix element is required. This poses a challenge to nuclear structure models. In particular, calculations based on the proton-neutron Quasiparticle Random Phase Approximation show significant discrepancies with experimental electron capture (EC) rates of the intermediate nucleus ...
Polar ionospheric heaters have generated ULF/ELF/VLF waves by modulating the auroral electrojet at D/E region altitudes. We present theoretical/computational results indicating that modulated F-region HF heating can generate ionospheric currents even in the absence of electrojet currents. The ELF currents are driven in a two-step process. First, the pressure gradient associated with F-region ...
ADP-ribosyltransferases (ADP-RTs) use NAD(+) to transfer an ADP-ribosyl group to target proteins. Although some ADP-RTs are bacterial toxins only few inhibitors are known. Here we present the development of fluorescence-based assays and a focussed library screening using kinase inhibitors as a new approach towards inhibitors of ADP-RTs. Different screening setups were established using surrogate ...
To increase read-out speed, sensitivity or specificity, an often applied strategy in fluorescence-based biomolecular spectroscopy and imaging is to simultaneously record two or more of the fluorescence parameters: intensity, lifetime, polarization or wavelength. This review highlights how additional, to-date largely unexploited, information can be extracted by monitoring long-lived, photo-induced ...
Production of tritium for weapons and fusion R and D programs and successful development of Inertial Confinement Fusion (ICF) technologies are important national goals. A conceptual design for an ICF facility to meet these goals is presented. FIRST STEP (Fusion, Inertial, Reduced-Requirements Systems Test for Special Nuclear Material, Tritium, and Energy Production) is a concept for a plant to ...
A new process, the Glass Material Oxidation and Dissolution System (GMODS), has been invented for the direct conversion of plutonium metal, scrap, and residue into borosilicate glass. The glass should be acceptable for either the long-term storage or disposition of plutonium. Conversion of plutonium from complex chemical mixtures and variable geometries into homogeneous glass (1) simplifies ...
The concentration of biomarkers, such as DNA, prior to a subsequent detection step may facilitate the early detection of cancer, which could significantly increase chances for survival. In this study, the partitioning behavior of mammalian genomic DNA fragments in a two-phase aqueous micellar system was investigated using both experiment and theory. The micellar system was ...
An emerging strategy in the regeneration and repair of bone is to use stem cells, including bone marrow mesenchymal stem cells, which are the most investigated and reliable source for tissue engineering, as well as circulating skeletal stem/progenitor cells, which are receiving abundant attention in regenerative medicine due to their ease of isolation and high osteogenic potential. Because ...
Engineered covers have been placed on top of buried/subsurface wastes to minimize water infiltration and therefore, release of hazardous contaminants. In order for the cover to protect the environment it must remain free of holes and breaches throughout its service life. Covers are subject to subsidence, erosion, animal intrusion, plant root infiltration, etc., all of which will affect the overall ...
Nanopantography, a radically new method for versatile fabrication of sub-20 nm features in a massively parallel fashion, represents a breakthrough in nanotechnology. The concept of this technique is to focus ion "beamlets" in parallel to write identical, arbitrary nano-patterns. Depending on the ion species, nanopatterns can be either etched, or deposited by nanopantography. An array of ...
This paper presents techniques for the extraction and analysis of crevice fluid microsamples. Results are presented from ambient temperature benchtop proof-of-principle testing with the spot microsample extraction technique and from the high temperature test method.
This report describes the implementation and evaluation of a proof-of-principle demonstration of selected functions of a distributed research network designed to support research on the comparative effectiveness and safety of marketed therapeutic agents. ...
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Astroparticle Physics. Data. Bases. Data Mining. Visualization ... Support Vector Clustering. Finds the support of a distribution. For novelty detection ... Self-Organizing Maps (SOM). " A prototype (proof-of- principle) has been ...
Spatially resolved measurements of electric fields at electrochemical interfaces would be a critical step toward further understanding and modeling the detailed structure of electric double layers. The goal of this project was to perform proof-of-principl...
First, a one-dimensional scoping study was performed for the gamma-ray shield of the ELMO Bumpy Torus proof-of-principle device to define appropriate shielding material and determine the required shielding thickness. The dose-equivalent results are analyz...
Although the incinerator tests did not represent optimized processing, general system design characteristics were established. The test results indicated that the rotary kiln incinerator would be most applicable in the Transuranic Waste Treatment Facility...
The authors have recently demonstrated two prototypes where photonics and microelectromechanical system (MEMs) technologies have been integrated to show proof-of-principle functionality for weapon surety functions. These activities are part of a program w...
In this research project, we had proposed to investigate the utility of the Bin1 gene as a diagnostic and/or prognostic marker in prostate malignancy and to perform proof-of-principle tests of its ability to induce apoptosis in androgen independent cancer...
Although preliminary proof-of-principle of the efficacy of barrier materials and processes, first developed by Battelle at PNNL and commercialized by Vitex, has been demonstrated at the laboratory scale, there are several challenges to the practical comme...
characteristics of the gradiometer, often to the point at which the interferometer fringe contrast decreased demonstrated proof-of-principle mea- surement of the Newtonian constant of gravity based on atom interferometric measurement of gravity-induced phase shifts presents a technique for the measurement of G
Recently, it has been shown that the density per particle, or shape function, determines all the properties of molecules and, more generally, finite Coulomb systems (e.g., clusters). Here, we provide numerical evidence for this 'existence' theorem, showing that atomic properties (specifically the kinetic energy and exchange energy) have simple approximate expressions in terms of ...
Calculated results of the dose rates from induced activity in the enclosure of the Elmo Bumpy Torus proof-of-principle device (EBT-P) are presented. A cylindrical model of EBT-P is used. EBT-P will have a hydrogen plasma and thus the plasma will not produce neutrons, but substantial numbers of photoneutrons will be produced and it is the induced activity from these ...
Calculated results of the dose rates from induced activity in the enclosure of the Elmo Bumpy Torus proof-of-principle device (EBT-P) are presented. A cylinder model of EBT-P is used. EBT-P will have a hydrogen plasma and thus the plasma will not produce neutrons, but substantial numbers of photoneutrons will be produced and it is the induced activity from these photoneutrons ...
