In the framework of an advanced Exotic Ion Beam facility, named SPES (Study and Production of Exotic Species), that will allow a frontier program both in nuclear and interdisciplinary physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma ...
Energy Citations Database
NASA Astrophysics Data System (ADS)
In the framework of an advanced Exotic Ion Beam facility project, named SPES (Study and Production of Exotic Species), that will allow a frontier program in Nuclear and Interdisciplinary Physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma ...
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer ce...
National Technical Information Service (NTIS)
Monte Carlo modelling of an irradiation facility, for boron neutron capture therapy (BNCT) application, using a set of advanced type, accelerator based, 3H(d,n)4He (D-T) fusion neutron source device is presented. Some general issues concerning the design of a proper irradiation beam shaping assembly, based on very ...
Accelerator-based neutron sources are an attractive alternative to nuclear reactors for providing epithermal neutron beams for Boron Neutron Capture Therapy. Based on clinical requirements and neutronics modeling the use of proton and deuteron induced reactions in {sup 7}Li and {sup 9}Be targets has been compared. Excellent epithermal neutron beams can be produced via the {sup ...
We present a conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture theory (BNCT). The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produced by the /sup 7/Li(p,n)/sup 7/Be reaction. A liquid lithium target and modulator assembly are designed to provide a high ...
A new conceptual design for an accelerator-based boron neutron capture therapy (ABNCT) facility based on the high-current low-energy proton beam driven by the linear accelerator at SARAF (Soreq Applied Research Accelerator Facility) incident on a windowless forced-flow liquid-lithium target, is described. The liquid-lithium target, currently in ...
PubMed
An innovative accelerator-based neutron source for BNCT has just started operation at the Budker Institute of Nuclear Physics, Novosibirsk. One of the main elements of the facility is a lithium target producing neutrons via the threshold (7)Li(p,n)(7)Be reaction at 25 kW proton beam with energies of 1.915 MeV or 2.5 MeV. The design of ...
Boron neutron capture therapy (BNCT) has had a varied history for the past half-century. Currently, clinical trials are underway at four sites in the United States, Netherlands, and Finland. Many organizations are considering the conversion of an existing research reactor or the design of a new reactor facility for BNCT treatment. We ...
In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the {sup 7}Li(p, n){sup 7}Be reaction by irradiating a thick LiF target with a 2.3 MeV ...
In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the 7Li(p, n)7Be reaction by irradiating a thick LiF target with a 2.3 MeV proton beam ...
In this work we present an optimized neutron beam shaping assembly for epithermal Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) and discuss the simulations leading to its design.
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by {sup 10}B energetic alpha particles and triton released at ...
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A program is under development at the Idaho National Engineering Laboratory (INEL) that involves using the Power Burst Facility (PBF) for research into Boron Neutron Capture Therapy (BNCT). BNCT utilizes the ionizing energy from boron-neutron capture to s...
At BNL, we have evaluated the beam current required to produce a clinical neutron beam for Boron Neutron Capture Therapy (BNCT) with an epithermal neutron flux of 10{sup 12} n/cm{sup 2}/hr. Experiments were carried out on a Van de Graaff accelerator at the Radiological Research Accelerator Facility (RARAF) at Columbia University. A thick Li target was ...
The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are ...
The experience from physical field for the BNCT project realized in NRI (Czech Republic) is presented. The physical methods and equipments for the design, construction and operation of facility for medical application are summarized. The comment is concentrated to the following items, especially: Sources for BNCT, calculation methods, ...
The authors plan to build a BNCT facility based on electrostatic quadrupole (ESQ) accelerator technology. It is an experimentally-proven technology capable of delivering a high proton current for producing a neutron intensity greater than what is required for BNCT clinical trials. They also present a design of a lithium ...
In preparation for future clinical BNCT trials, neutron production via the 7Li(p,n) reaction as well as subsequent moderation to produce epithermal neutrons have been studied. Proper design of a moderator and filter assembly is crucial in producing an opt...
Boron Neutron Capture Therapy (BNCT) in the United States has entered into a new phase with the initiation of clinical trials using neutron sources at the Brookhaven National Laboratory and the Massachusetts Institute of Technology. If these trials are su...
This study considers the radiation safety aspects of several designs discussed in a previous report of an accelerator-based source of neutrons, based on the [sup 7]Li(p,n) reaction, for a Boron Neutron Capture Therapy (BNCT) Facility at Lawrence Berkeley National Laboratory (LBNL). determines the optimal radiation shield thicknesses for the patient ...
Current accelerator-based neutron source concepts for boron neutron capture therapy (BNCT) are centered on the lithium (p,n) reaction. The near lithium threshold source concept uses proton energies <~100 keV above the reaction threshold energy (1.88 MeV). For deeply seated brain tumors, epithermal (1 eV to 10 keV) neutrons are needed to penetrate the ...
Building a boron neutron capture therapy (BNCT) facility is foreseen within the reconstruction of the Research Reactor IRT (IRT) of the Institute for Nuclear Research and Nuclear Energy of the Bulgaria Academy of Sciences (INRNE). The development of BNCT at IRT plays a very significant role in the plan for sustainable application of ...
Methods for dosimetry of epithermal neutron beams used in boron neutron capture therapy (BNCT) have been developed and utilised within the Finnish BNCT project as well as within a European project for a code of practise for the dosimetry of BNCT. One outcome has been a travelling toolkit for BNCT dosimetry. It ...
During the last few years, IBA started the development of an accelerator-based BNCT system. The accelerator is a Dynamitron built by RDI in USA and will produce a 20 mA proton beam at 2.8 MeV. Neutrons will be produced by the (7)Li(p,n)(7)Be nuclear reaction using a thin lithium target. The neutron energy spectrum will be tailored using a beam shaping assembly. This overview ...
Boron Neutron Capture Therapy (BNCT) is being studied as a possible radiotherapic treatment for some cancer types. Neutron energy for penetrating into tissue should be in the epithermal range. Different methods are used for neutron production. Electron accelerators are an alternative way for producing neutrons in electron-photon-neutron processes. Optimization of ...
A numerical optimization of a Beam Shaping Assembly (BSA) for Accelerator Based-Boron Neutron Capture Therapy (AB-BNCT) has been performed. The reaction (7)Li(p,n)(7)Be has been considered using a proton beam on a lithium fluoride target. Proton energy and the dimensions of a simple BSA geometry have been varied to obtain a set of ...
known as boron neutron capture therapy (BNCT), the new com- pounds contain the element boron and become- ment to achieve the optimum radiation dose to the tumor while sparing healthy normal cells. While BNCT therapy. Scientists are currently testing the effectiveness of clinical BNCT in the U.S. (Massachu- setts
E-print Network
Highlights of the PBF/BNCT Program during March include progress within the areas of: Gross Boron Analysis in Tissue Blood and Urine, Analytical Methodologies Development for BSH (Sodium Borocaptate) Purity Determination, Boron Microscopic (Subcellular) Analytical Development, Noninvasive Boron Quantification Determination, Dosimetry, Analytical Radiation Transport and ...
Highlights of the PBF/BNCT Program during December include progress in several areas. Topics included: gross boron analysis in tissue blood and urine; analytical methodologies development for BSH (Sodium Borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; analytical radiation ...
This report presents a summary of accomplishments and highlights in the PBF/BNCT Program for January 1991. The report includes information on the BNCT brain tumor and melanoma research programs, technical support and modifications, PBF operations, a milestone summary, and animal data charts. Projects include Supporting Technology Development; Large Animal ...
Highlights of the PBF/BNCT Program during June include progress within the areas of gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; and analytical radiation transport and ...
Highlights of the PBF/BNCT Program during March include: gross boron analysis in tissue blood and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; and analytical radiation transport and interaction modeling for ...
Highlights of the PBF/BNCT Program during May include progress within the areas of: gross boron analysis in tissue blood and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; and analytical radiation transport and ...
The development of Boron Neutron Capture Therapy (BNCT) has been progressing in both ^{10 }B compound development and testing and neutron beam delivery. Animal tests are now in progress with several ^{10}B compounds and once the results of these animal tests are promising, patient trials can be initiated. The objective of this study is to create a treatment planning method ...
This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, ...
Highlights of the PBF/BNCT (Power Burst Facility/Boron Neutron Capture Therapy) during March 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine, analytical methodologies development for BSH (Borocaptate Sodium) purity determination, dosimetry, analytical radiation transport and interaction modeling for ...
We present a conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture theory (BNCT). The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produc...
... The new hybrid thermal neutron facility at TAPIRO reactor for BNCT ... for Testing and Materials, Standard Practice for Use of the Alanine�EPR ... ...
NBII National Biological Information Infrastructure
This PBF/BNCT Program Monthly Bulletin is the primary vehicle for prompt national and international dissemination of research progress and the development status of tools essential for optimum BNCT clinical application. Accordingly, beginning with this issue, PBF neutron-filter design progress and PBF standby task summaries will be added to the subjects ...
In this article, we will consider several core configurations and run the core calculation with MCNP to obtain the neutrons distribution at THOR. The thermal neutron flux inside the vertical tubes (VT-B-VT-E) and the fast neutron flux in the first row facing to the boron neutron capture therapy (BNCT) facility (I3-I5) were tallied for indication. Based on ...
Boron neutron capture therapy (BNCT) in the United States has entered into a new phase with the initiation of clinical trials at Brookhaven National Laboratory and at the Massachusetts Institute of Technology. If these trials are successful at demonstrating the efficacy of BNCT as a viable treatment for glioblastoma multiforme, then there will be an ...
Boron Neutron Capture Therapy (BNCT) is currently performed on patients at nuclear reactors. At the same time the international BNCT community is engaged in the development of alternative facilities for in-hospital treatments. This paper investigates the potential of a novel high-output D D neutron generator, developed at Lawrence ...
Thick lithium targets are excellent sources of neutrons for accelerator boron neutron capture therapy (BNCT), but the low melting point of lithium (181 deg. C) and a need for high proton currents make target heating a concern. However, because neutrons are not produced for proton energies below the {sup 7}Li(p,n){sup 7}Be reaction threshold of 1.88 MeV, the lithium targets ...
Since 1986, the Idaho National Engineering Laboratory (INEL) has been involved in the development of epithermal neutron sources for BNCT. The INEL effort was instrumental in the implementation of an epithermal neutron beam at the Brookhaven Medical Research Reactor at Brookhaven National Laboratory. Recently, the INEL's effort has been directed toward developing advanced ...
Previously, the authors have developed the in-phantom neutron field assessment parameters T and D (Tumor) for the evaluation of epithermal neutron fields for use in BNCT. These parameters are based on an energy-spectrum-dependent neutron normal-tissue RBE and the treatment planning methodology of Gahbauer and his co-workers, which includes the effects of dose fractionation. In ...
For Boron Neutron Capture Therapy (BNCT) on brain tumor, a medical irradiation facility has been installed in the Japan Research Reactor No.2 (JRR-2) in Japan Atomic Energy Research Institute (JAERI). This facility consists of a neutron beam tube, an irra...
This report describes the conceptual design for an epithermal neutron beam facility at the Georgia Tech research reactor (GTRR). Brief comparisons are made to the Brookhaven Medical research reactor with regard to fast neutron and gamma contamination and accessibility of the facility.
Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) a theoretical study was performed to assess the treatment planning capability of different configurations of an optimized beam shaping assembly for such a ...
This report presents a summary of accomplishments and highlights in the PBF/BNCT Program for December 1990. The report includes information on the BNCT brain tumor and melanoma research programs, technical support and modifications, PBF operations, a milestone summary, and animal data charts. Projects include: Supporting Technology; Large Animal Studies; ...
This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in T...
Highlights of the PBF/BNCT Program during January 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH purity determination; noninvasive boron quantitative determination; dosimetry; analytical radiation transport and interaction modeling for BNCT; large animal model ...
An accelerator-based BNCT facility is under construction at the Berkeley Lab. An electrostatic-quadrupole (ESQ) accelerator is under development for the production of neutrons via the (sup 7)Li(p,n)(sup 7)Be reaction at proton energies between 2.3 and 2.5...
The National Atomic Energy Commission of Argentina (CNEA) constructed a novel thermal neutron source for use in boron neutron capture therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The aim of the present study was to perform a dosimetric characterization of the facility and undertake ...
Studies were performed to assess theoretical tumor control probability (TCP) for brain-tumor treatment with boron neutron capture therapy (BNCT) using epithermal neutron sources from reactors. The existing epithermal-neutron beams at the Brookhaven Medical Research Reactor Facility (BMRR), the Petten High Flux Reactor Facility (HWR) ...
Some research reactors have been selected for the development of boron neutron capture therapy (BNCT) in the United States like the Massachusetts Institute of Technology research reactor, the University of Missouri research reactor 2 or the Brookhaven Medical Research Reactor, among others. These reactors have received excellent analyses and designs to accommodate extremely ...
Boron Neutron Capture Therapy, a promising modality for the treatment of malignant tumors, relies on the use of neutron beams of suitable energy and intensity. For deep-seated tumors, simulations indicate that the optimal neutron energy is in the epithermal region, and in particular between 1 and 10 keV. Therapeutic neutron beams of high spectral purity could be produced with low-energy ...
This work reports on the characterisation of a neutron beam shaping assembly (BSA) prototype and on the preliminary modelling of a treatment room for BNCT within the framework of a research programme for the development and construction of an accelerator-based BNCT irradiation facility in Buenos Aires, Argentina. The BSA prototype ...
Oak Ridge National Laboratory Physics Division The Oak Ridge Electron Linear Accelerator Pulsed Neutron Source The ORELA is a powerful electron accelerator-based neutron source...
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Within the Petten BNCT project a thermal neutron facility for radiobiological studies is needed for further test and development of boron compounds. The Argonaut reactor of ECN, the Low Flux Reactor oeprating at a power of 30 kW, offers opportunities for ...
This report presents a summary of accomplishments and highlights in the PBF/BNCT Program for December 1990. The report includes information on the BNCT brain tumor and melanoma research programs, technical support and modifications, PBF operations, a mile...
Highlights of the PBF/BNCT (Power Burst Facility/Boron Neutron Capture Therapy) during March 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine, analytical methodologies development for BSH (Borocaptate Sodium) pur...
Highlights of the PBF/BNCT Program during March include: gross boron analysis in tissue blood and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninv...
Highlights of the PBF/BNCT Program during May include progress within the areas of: gross boron analysis in tissue blood and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) ana...
Highlights of the PBF/BNCT Program during November include progress in several areas. Included are: Gross Boron Analysis in Tissue, Blood, and Urine (165 samples were analyzed during the month with 107 additional samples received); Analytical Methodologie...
A 300 kW small medical reactor was designed to be used for boron neutron capture therapy (BNCT) at KAIST in 1996. In this paper, analysis for the core life cycle of the original design of the BNCT facility and modifications of the fuel assembly configuration and enrichment to get a proper life cycle were performed and a criticality, ...
A 300 kW small medical reactor was designed to be used for boron neutron capture therapy (BNCT) at KAIST in 1996 [1]. In this paper, analysis for the core life cycle of the original design of the BNCT facility and modifications of the fuel assembly configuration and enrichment to get a proper life cycle were performed and a ...
This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and ...
This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF ...
This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, ...
This work discusses the development of online dosimetry of the boron dose via Single Photon Emission Computed Tomography (SPECT) during a BNCT treatment irradiation. Such a system will allow the online computation of boron dose maps without the large current uncertainties in the assessment of the boron concentration in different tissues. The first tomographic boron dose image ...
A conceptual design of an inertial electrostatic confinement (IEC) neutron source for boron neutron capture therapy (BNCT) is described. The IEC system produces neutron fusion reactions, where ions are accelerated toward each other by a spherical gridded structure. Significant research and development are needed to scale the system up to the required level, which is 10{sup 19} ...
The CWDD (Continuous Wave Deuterium Demonstrator) accelerator was designed to accelerate 80 mA cw of D{sup {minus}} to 7.5 MeV. Most of the hardware for the first 2 MeV was installed at Argonne and major subsystems had been commissioned when program funding from the Ballistic Missile Defense Organization ended in October 1993. Renamed the Argonne Continuous Wave Linac (ACWL), we are proposing to ...
A new multi-modal Monte-Carlo radiotherapy planning system (developing code: JCDS-FX) is under development at Japan Atomic Energy Agency. This system builds on fundamental technologies of JCDS applied to actual boron neutron capture therapy (BNCT) trials in JRR-4. One of features of the JCDS-FX is that PHITS has been applied to particle transport calculation. PHITS is a ...
A source for boron neutron capture therapy (BNCT) comprises a body of photoneutron emitter that includes heavy water and is closely surrounded in heat-imparting relationship by target material; one or more electron linear accelerators for supplying electron radiation having energy of substantially 2 to 10 MeV and for impinging such radiation on the target material, whereby ...
DOEpatents
In boron neutron capture therapy (BNCT) the delivered dose to the patient depends both on the neutron beam characteristics and on the {sup 10}B body distribution which, in turn, is governed by the tumor specificity of the {sup 10}B drug-carrier. BNCT dosimetry is a complex matter due to the several interactions that neutrons can undergo with the different ...
In boron neutron capture therapy (BNCT) the delivered dose to the patient depends both on the neutron beam characteristics and on the 10B body distribution which, in turn, is governed by the tumor specificity of the 10B drug-carrier. BNCT dosimetry is a complex matter due to the several interactions that neutrons can undergo with the different nuclei ...
We describe Monte Carlo simulations of three facilities for the production of epithermal neutrons for Boron Neutron Capture Therapy (BNCT) and examine general aspects and problems of designing the spectrum-shaping assemblies to be used with these neutron sources. The first facility is based on an accelerator-driven low-power ...
This report discusses the monthly progress of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNLT) program for cancer treatment. Highlights of the PBF/BNCT Program during July 1990 include progress within the areas of: Gross boron analysis in tissue, blood, and urine; noninvasive boron quantitative determination; analytical radiation transport ...
Highlights of the Power Burst Facility Boron Neutron Capture Therapy (PBF/BNCT) Program during April 1990 include progress within areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (Borocaptate Sodium) purity determination; noninvasive boron quantitative determination; analytical radiation transport and ...
The technical design of the research reactor IRT in Sofia is in progress. It includes an arrangement for a BNCT facility for tumor treatment. Modeling of geometry and material composition of filter/collimator for the BNCT beam tube on IRT has been carried out following the beam tube configuration of the Massachusetts Institute of ...
The technical feasibility of using the TREAT reactor facility for boron neutron capture therapy (BNCT) research was assessed. Using one-dimensional neutronics calculations, it was shown that the TREAT core neutron spectrum can be filtered to reduce the undesired radiation (contamination) dose per desired neutron more effectively than can the core spectra ...
The SPES-BNCT ongoing project of the Istituto Nazionale di Fisica Nucleare (INFN) is aimed at the construction at the Laboratori Nazionali di Legnaro (LNL) of an accelerator-based (AB), high-flux thermal neutron beam facility devoted to boron neutron capture therapy (BNCT) experimental treatment of extended skin melanoma, in the ...
Boron magnetic resonance imaging (MRI) and spectroscopy (MRS) were developed in support of the noninvasive boron quantification task of the Idaho National Engineering Laboratory (INEL) Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) program....
... BNCT). The procedure involved boron infusion prior to hepatectomy, irradiation of the explanted liver at the thermal ... the liver that cannot be removed by partial hepatectomy, chemotherapy is the only t...
Results are presented for a characterisation of the neutron beam of the LVR-15 reactor of NRI in Rez in the Czech Republic. The neutron fluence rate in the free beam have been determined with 2 multifoil sets. Representative values for the gamma dose rate...
The BNCT radiation field is complex because different beam components are mixed, each one having different relative biological effectiveness (RBE). Microdosimetry with tissue-equivalent proportional counters (TEPC) has proven to be an ideal dosimetric technique for mixed radiation fields, because it is able both to measure the absorbed dose and to assess the radiation field ...
A system for testing potential BNCT pharmaceuticals in cell cultures has been developed with the cooperation of Oak Ridge National Laboratory (ORNL), the University of Tennessee Chemistry Department and the University of Tennessee Nuclear Engineering Department. A BNCT test model has been established with the use of the human lung cancer cell line A 549. ...
This report is the result of a request by the Secretary of Energy to the Institute of Medicine to convene an expert committee to evaluate the Idaho National Engineering Laboratory proposal to convert its Power Burst Facility (PBF) for use in research and development for Boron Neutron Capture Therapy (BNCT). The Committee was asked to conduct the evaluation ...
Initial physical dosimetry measurements have been completed using activation spectrometry and thermoluminiscent dosimeters to characterize the BNCT irradiation facility developed at the RA-1 research reactor operated by the Argentine National Atomic Energy Commission in Buenos Aires. Some biological scoping irradiations have also been completed using a ...
The Chalk River Laboratories of Atomic Energy of Canada Ltd. was a major centre for Accelerator based physics for the last fifty years. As early as 1946, nuclear structure studies were started on Cockroft-Walton accelerators. A series of accelerators followed, including the world's first Tandem, and the MP Tandem, Superconducting Cyclotron (TASCC) ...
A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used ...
Fast neutron radiotherapy (FNT) can be combined with boron neutron capture therapy (BNCT). The selective incremental absorbed dose in the target volume that is thus obtained may be sufficient to produce a significant improvement in tumor control probability in some cases. Potential applications include certain non-small-cell lung tumors; head and neck tumors; prostate tumors; ...
A refined dose assessment method has been used now in the THOR BNCT facility, which takes into account more delicate corrections, carefully handled calibration factors, and the spectrum- and kerma-weighted k(t) value. The refined method solved the previous problem of negative derived neutron dose in phantom at deeper positions. With the improved dose ...
Each medical intervention must be performed respecting Health Protection directives, with special attention to Quality Assurance (QA) and Quality Control (QC). This is the basis of safe and reliable treatments. BNCT must apply QA programs as required for performance and safety in (conventional) radiotherapy facilities, including regular testing of ...
The Georgia Institute of Technology research reactor (GTRR) is capable of producing one of the best neutron beams for boron neutron capture therapy (BNCT) applications. Such a beam is obtained when a filter designed by Klee and Karam is installed. The filter consists of three parts: an in-vessel filter located between the core and the reactor tank wall, an ex-vessel filter ...
Boron Neutron Capture Therapy (BNCT) is a promising bimodal radiation therapy used primarily for highly malignant gliomas. Specification of the absorbed and biologically effective dose in BNCT is a primary concern in the implementation of this therapeutic technique. Providing accurate dosimetry for the complex mixed field encountered in ...
We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. BNCT is based on the selective accumulation of (10)B carriers in a tumor followed by neutron irradiation. Within the context of exploring the potential therapeutic efficacy of BNCT for ...
To realize the accelerator-based boron neutron capture therapy (BNCT) at the Cyclotron and Radioisotope Center of Tohoku University, the feasibility of a cyclotron-based BNCT was evaluated. This study focuses on optimizing the epithermal neutron field with an energy spectrum and intensity suitable for BNCT for various combinations of ...
At Kyoto University Research Reactor Institute (KURRI), 275 clinical trials of boron neutron capture therapy (BNCT) have been performed as of March 2006, and the effectiveness of BNCT has been revealed. In order to further develop BNCT, it is desirable to supply accelerator-based epithermal-neutron sources that can ...
Neutrons can be produced with low-energy ion accelerators for many applications, such as the characterisation of neutron detectors, the irradiation of biological samples and the study of the radiation damage in electronic devices. Moreover, accelerator-based neutron sources are under development for boron neutron capture therapy (BNCT). Thin targets are ...
Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H{sup +} yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the D-D or D-T fusion reactions. In this new ...
A novel application of the 10B(n, (alpha) )7Li nuclear reaction for the treatment of rheumatoid arthritis is under development. this application, called Boron Neutron Capture Synovectomy (BNCS), is briefly described here and the differences between BNCS and Boron Neutron Capture Therapy (BNCT) are discussed in detail. These differences lead to substantially altered demands on ...
Boron neutron capture therapy (BNCT) is a bimodal form of radiation therapy for cancer. The first component of this treatment is the preferential localization of the stable isotope {sup 10}B in tumor cells by targeting with boronated compounds. The tumor and surrounding tissue is then irradiated with a neutron beam resulting in thermal neutron/{sup 10}B reactions ({sup ...
This is the progress report and proposed research objectives for the project entitled An Accelerator Neutron Source for BNCT.'' The progress report is for the time period from July 15, 1990 to date. The proposal is for the upcoming budget period from July 15, 1991 to July 14, 1992. The objectives of this project are to design and test the target assembly ...
BNCT facility in the Institute of Atomic Energy in Otwock-Swierk is under construction at the horizontal channel H2 of the research reactor MARIA. Measurements of the neutron energy spectrum performed at the front of the H2 experimental channel, have shown that flux of epithermal neutrons (above 10 keV) at the BNCT irradiation port was ...
The collision type central to BNCT is (10)B(n, alpha)(7)Li, however, other types of nuclear reactions also take place in the patient. In addition to the major elements (H, C, N, O), minor elements such as Na, Mg, P, S, Cl, K, Ca and Fe present in body tissues also interact in neutron collisions. Detailed accounting of the above not only provides a better understanding of ...
A new thermal neutron irradiation facility, devoted to carry out both dosimetric and radiobiological studies on boron carriers, which are being developed in the framework of INFN BNCT project, has been installed at the ENEA Casaccia TAPIRO research fast reactor. The thermal column, based on an original, hybrid, neutron spectrum shifter configuration, has ...
Highlights of the Power Burst Facility Boron Neutron Capture Therapy (PBF/BNCT) Program during April 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (Borocaptate Sodium) purity determination; noninvasive boron quantitative determination; operator training was ...
Abstract We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. BNCT is based on the selective accumulation of 10B carriers in a tumor followed by neutron irradiation. Within the context of exploring the potential therapeutic efficacy of ...
In 2001, at the TRIGA reactor of the University of Pavia (Italy), a patient suffering from diffuse liver metastases from an adenocarcinoma of the sigmoid was successfully treated by boron neutron capture therapy (BNCT). The procedure involved boron infusion prior to hepatectomy, irradiation of the explanted liver at the thermal column of the reactor, and subsequent ...
The National Atomic Energy Commission of Argentina (CNEA) has constructed a thermal neutron source for use in Boron Neutron Capture Therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The Idaho National Laboratory (I...
Highlights of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program in November, 1990 are described. One of our major projects is support of technological development. In this area, progress has been seen in gross boron analysis of bio...
This report discusses the monthly progress of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNLT) program for cancer treatment. Highlights of the PBF/BNCT Program during July 1990 include progress within the areas of: Gross boron analysis in...
This document provides highlights of the PBF/BNCT Program during June 1990 include progress within the areas of: supporting technology development; large animal model studies; neutron source and facility preparation; administration and common support, and...
This document provides highlights of the PBF/BNCT Program during June 1990 include progress within the areas of: supporting technology development; large animal model studies; neutron source and facility preparation; administration and common support, and PBF operations.
Highlights of the Power Burst Facility Boron Neutron Capture Therapy (PBF/BNCT) Program during April 1990 include progress within areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (Borocaptate Sodium)...
Highlights of the Power Burst Facility Boron Neutron Capture Therapy (PBF/BNCT) Program during April 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (Borocaptate Sod...
Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration ...
Boron Neutron Capture Therapy (BNCT) in the United States has entered into a new phase with the initiation of clinical trials using neutron sources at the Brookhaven National Laboratory and the Massachusetts Institute of Technology. If these trials are successful at demonstrating the efficacy of BNCT as a viable treatment for glioblastoma multiforme, then ...
For several years, research has been ongoing in the Ohio State University (OSU) Nuclear Engineering Program toward the development of an accelerator-based irradiation facility (ANIF) neutron source for boron neutron capture therapy (BNCT). The ANIF, which is planned to be built in a hospital, has been conceptually designed and analyzed. After Qu, an OSU ...
An accelerator-driven thermal neutron source for BNCT, planned to be installed at the INFN Laboratori Nazionali di Legnaro (LNL), is in progress in the framework of the SPES (selective production of exotic species) research program. The most critical element of such a facility is the construction of a reliable neutron converter based on the (9)Be(p,xn) ...
There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). Progress on an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator for Accelerator-Based (AB)-BNCT is described here. ...
Accelerator-based atomic physics experiments at Brookhaven presently use heavy-ion beams from the Dual MP Tandem Van de Graaff Accelerator Facility for atomic physics experiments of several types. Work is presently in progress to develop experiments which will use the intense photon beams which will be available in the near future from the ultraviolet (uv) ...
The International Fusion Materials Irradiation Facility (IFMIF) is proposed as an advanced accelerator-based neutron source for high-flux irradiation testing of large-sized fusion reactor components. The facility would require only small extensions to exi...
Some remarkable advances have been made in the last years on the SPES-BNCT project of the Istituto Nazionale di Fisica Nucleare (INFN) towards the development of the accelerator-driven thermal neutron beam facility at the Legnaro National Laboratories (LNL), aimed at the BNCT experimental treatment of extended skin melanoma. The ...
Various quality control (QC) and quality assurance (QA) procedures of the boron neutron capture therapy (BNCT) beam at the Tsing Hua Open-pool Reactor (THOR) are established to ensure beam availability and quality. The QC/QA methods mainly employ foil activation and paired ionization chambers, respectively, for beam intensity check and dose assessment. Beam intensity is ...
The usable range of thickness for the solid lithium target in the accelerator-based neutron production for BNCT via the near-threshold (7)Li(p,n)(7)Be reaction was investigated. While the feasibility of using a (7)Li-target with thickness equal to that which is required to slow down a mono-energetic 1.900 MeV incident proton to the 1.881 MeV threshold of the (7)Li(p,n)(7)Be ...
The usable range of thickness for the solid lithium target in the accelerator-based neutron production for BNCT via the near-threshold 7Li(p,n)7Be reaction was investigated. While the feasibility of using a 7Li-target with thickness equal to that which is required to slow down a mono-energetic 1.900 MeV incident proton to the 1.881 MeV threshold of the 7Li(p,n)7Be reaction ...
Near-threshold boron neutron capture therapy (BNCT) uses proton energies only tens of rev above the (pan) reaction threshold in lithium in order to reduce the moderation requirements of the neutron source. The goals of this research were to prove the feasibility of this near-threshold concept for BNCT applications, using both calculation and experiment, ...
New thermal neutron irradiation facilities to perform cell and small-animal irradiations for Boron Neutron Capture Therapy research have been installed at the Missouri University Research Reactor and at the RA-3 research reactor facility in Buenos Aires, Argentina. Recognizing the importance of accurate and reproducible physical beam dosimetry as an ...
Highlights of the PBF/BNCT Program during January 1990 include progress within the areas of: gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH purity determination; noninvasive boron quantitative determination;...
Highlights of the PBF/BNCT Program during February 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, Analytical Methodologies Development for BSH (Borocaptate Sodium) Purity Determination, Noninvasive Boron Quant...
A neutron beam simulation study is carried out to determine the most suitable neutron energy for treatment of shallow and deep-seated brain tumors in the context of Boron Neutron Capture Therapy (BNCT). Two figures-of-merit, the therapeutic gain and the neutron fluence are utilized as beam assessment parameters. An irradiation cavity is used instead of a parallel beam port for ...
A hybrid photoneutron target including natural uranium has been studied for a 20 MeV linear electron accelerator (Linac) based Boron Neutron Capture Therapy (BNCT) facility. In this study the possibility of using uranium to increase the neutron intensity has been investigated by focusing on the time dependence behavior of the build-up and decay of the ...
Fricke gel dosimeters in the form of layers are suitable to reconstruct bidimensional distributions of the absorbed dose; in accordance with their chemical composition and applying suitably developed algorithms, they can provide dose images of the different radiation components in a BNCT field. After the description of the applied method, this work presents the results ...
Boron neutron capture therapy (BNCT) of brain tumours was investigated using thermal neutrons generated by a middle-power research reactor such as the TRIGA-II. The spatial distributions of neutrons and gamma rays were measured using a head phantom at different collimator apertures. Total depth-dose distributions were deduced from these results and were evaluated. We also ...
The dual ionisation chamber technique is the recommended method for mixed field dosimetry of epithermal neutron beams. This paper presents initial data from an ongoing inter-comparison study involving two identical pairs of ionisation chambers used at the BNCT facilities of Petten, NL and of the University of Birmingham, UK. The goal of this study is to ...
The method of an evaluation for the dose characteristics of BNCT is presented, and an eccentric core design for the TRIGA-II reactor is proposed. The authors have defined the [open quotes]irradiation time[close quotes] as the time of irradiation in which the [open quotes]maximum 1 [mu]g/g dose[close quotes] becomes 3,000 RBE-cGy, because they assumed that the normal tissue ...
Clinical trials for boron neutron capture therapy (BNCT) by using the medical irradiation facility installed in Japan Research Reactor No. 4 (JRR-4) at Japan Atomic Energy Research Institute (JAERI) have been performed since 1999. To carry out the BNCT procedure based on proper treatment planning and its precise implementation, the ...
Radiation sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. Polymer gel dosimeter known by the acronym MAGIC has been tested for evaluation of its use in boron neutron capture (BNCT) dosimetry. We irradiated a large (diameter 10 cm, length 20 cm) cylindrical gel phantom in the epithermal neutron beam of the Finnish ...
The Neutron Therapy Facility at Fermilab has treated cancer patients since 1976. Since then more than 2,300 patients have been treated and a wealth of clinical information accumulated. The therapeutic neutron beam at Fermilab is produced by bombarding a beryllium target with 66 MeV protons. The resulting continuous neutron spectrum ranges from thermal to 66 MeV in neutron ...
DOE R&D Accomplishments Database
The GAFCHROMIC(�) EBT2 dosimetry film has been studied as a rapid QC/QA tool for 2D dose profile mapping in the BNCT beam at THOR. The pixel values of the EBT2 film image were converted to the 2D dose profile using a dose calibration curve obtained by 6-MV X-ray. The reproducibility of the 2D dose profile measured using the EBT2 film in the PMMA phantom was preliminarily ...
Calculations of the epithermal-neutron yield of photoneutrons from a uranium-beryllium converter using a 27 MeV electron linear accelerator have been investigated. In this concept, relativistic electron beams from a 30 MeV LINAC impinge upon a small uranium sphere surrounded by a cylindrical tank of circulating heavy water (D2O) nested in a beryllium cube. The photo-fission neutron spectrum from ...
In one embodiment there is provided an application of the {sup 10}B(n,{alpha}){sup 7}Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam ...
In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam ...
Boron neutron capture therapy (BNCT) of malignant brain tumors has been efficiently performed since March 1977, and the first human case of malignant melanoma was also successfully treated on July 1987 in our reactor (Musashi reactor, TRIGA-II, 100 kW). To obtain both good irradiation field characteristics and a better irradiation facility, some tests and ...
Moderating material has been installed in the original thermal-neutron filter region of the Washington State University (WSU) TRIGA� type reactor to produce an epithermal-neutron beam. Attention has been focused upon the development of a convenient, local, epithermal-neutron beam facility at WSU for collaborative Idaho National Engineering and Environmental Laboratory ...
In this work we describe the present status of an ongoing project to develop a tandem-electrostatic-quadrupole (TESQ) accelerator facility for accelerator-based (AB) BNCT at the Atomic Energy Commission of Argentina in Buenos Aires. The project final goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron ...
In Boron Neutron Capture Therapy (BNCT) of malignant brain tumors, the energy dependence of a clinically relevant Relative Biological Effectiveness (RBE) for epithermal neutrons, RBE(En), is important in neutron field design. In the first half of this paper, we present the development of an expression for the energy dependent normal-tissue RBE, RBE(En). We then calculate a ...
The {sup 7}Li(p,n){sup 7}Be reaction has been investigated as an accelerator-driven neutron source for proton energies between 2.1 and 2.6 MeV. Epithermal neutron beams shaped by three moderator materials, Al/AlF{sub 3}, {sup 7}LiF, and D{sub 2}O, have been analyzed and their usefulness for boron neutron capture therapy (BNCT) treatments evaluated. Radiation transport through ...
The M-011 thermal neutron beam has been reconstituted and upgraded to provide a high intensity and high quality facility for preclinical and certain clinical studies. Intensities of thermal neutrons in the beam range from 5.0-8.5 x 109 n cm-2 s-1. Beam contamination is at a low level where it has no practical influence on beam performance. New computer controlled dose and beam ...
HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in ...
The Rotating Target Neutron Source (RTNS-II) facility provides an intense source of 14-MeV neutrons for the fusion energy programs of Japan and the United States. Each of the two identical accelerator-based neutron sources is capable of providing source strengths in excess of 3 x 10/sup 13/ n/s using deuteron beam currents up to 150 mA. The present status ...
iThemba Laboratory for Accelerated Based Sciences is a multi-disciplinary research centre, operated by the National Research Foundation. It provides national accelerator and ancillary facilities for research and training in physical, biomedical, chemical and material sciences, research in, and the treatment of, cancer with energetic ...
The d-Li Neutron Source concept, which includes a high-current dueteron linac, is an outgrowth of attempts made to use the BNL, 200-MeV proton linac BLIP facility to do radiation damage studies. It included a 100 mA, 30-MeV deuteron linear accelerator and...
Research and development activities are summarized in the following areas: Holifield Heavy Ion Research Facility, nuclear physics, the UNISOR program, accelerator-based atomic physics, theoretical physics, nuclear science applications, atomic physics and plasma diagnostics for fusion program, high-energy physics, the nuclear data project, and the ...
The technologies that are being utilized to design and build the target systems for a state-of-the-art accelerator- based neutron source, the Spallation Neutron Source (SNS), are discussed. Emphasis is given to the technology issues that present the greatest challenges. The present facility configuration, ongoing analysis, and ...
Fermilab's hadron physics research continues in all its accelerator-based programs. These efforts will be identified, and the optimization of the Fermilab schedules for physics will be described. In addition to the immediate plans, the Fermilab Long Range Plan will be cited, and the status and potential role of a new proton source, the Proton Driver, is described.
A single-cell test stand has been constructed at LLNL for studies aimed at improving the performance of the FXR radiographic facility. It has guided the development of diagnostics, pulsed power improvements, machine maintenance, and interface issues relevant to the entire accelerator. Based on this work, numerous machine improvements ...
A proposal to design, construct, and operate a D--Li intense neutron source for CTR materials research is discussed. Information pertaining to the following areas is given: (1) radiation damage effectiveness, (2) Linac design and performance, (3) target design and performance, (4) experimental area design, (5) construction schedule, (6) construction costs, (7) preliminary design and ...
threshold for accelerator boron neutron capture therapy. Med. Phys. 27(1), 192�202 (2000). 11. Schmid, EAN ACCELERATOR-BASED NEUTRON MICROBEAM SYSTEM FOR STUDIES OF RADIATION EFFECTS Yanping Xu1 2010 A novel neutron microbeam is being developed at the Radiological Research Accelerator Facility
The non-surgical brain cancer treatment modality, Boron Neutron Capture Therapy (BNCT), requires the use of an epithermal neutron beam. This purpose of this thesis was to design an epithermal neutron beam at the University of Virginia Research Reactor (UVAR) suitable for BNCT applications. A suitable epithermal neutron beam for BNCT ...
A mathematical model to calculate the theoretical cell survival probability (nominally, the cell survival fraction) is developed to evaluate preclinical treatment conditions for boron neutron capture therapy (BNCT). A treatment condition is characterized by the neutron beam spectra, single or bilateral exposure, and the choice of boron carrier drug (boronophenylalanine (BPA) ...
An accelerator-based BNCT facility is under development at the Lawrence Berkeley National Laboratory. Neutrons will be produced via the {sup 7}Li(p,n) reaction at proton energies of about 2.5 MeV with subsequent moderation and filtering for shaping epithermal neutron beams for BNCT. Moderator, filter, and shielding assemblies have been ...
Accelerator-based transmutation is being studied by ECN within its general nuclear waste transmutation programme RAS. In this paper the following contributions are presented: 1) Evaluation of cross sections at intermediate energies, within an international frame given by NEA, 2) Cell calculations on the equilibration of transuranium actinides in thermal molten-salt ...
The MCNP4B Monte Carlo transport code is used in a feasibility study of the epithermal neutron boron neutron capture therapy facility in the thermalizing column of the 250-kW TRIGA Mark II reactor at the Jozef Stefan Institute (JSI). To boost the epithermal neutron flux at the reference irradiation point, the efficiency of a fission plate with almost 1.5 kg of 20% enriched ...
A large fraction of the proposals for accelerator-based boron neutron capture therapy (BNCT) facilities consider neutron sources consisting of 2.5-MeV protons impinging on a {sup 7}Li target. Nevertheless, several studies considered accelerator-target concepts offering a significantly harder neutron spectrum. The harder the source neutron spectrum, the ...
A comprehensive effort is underway to design a high- performance BNCT facility at the 2 MW University of Virginia research reactor. This endeavor includes detailed core criticality and leakage calculations, coupled neutron/photon transport analyses, and dosimetry computations. Detailed geometries are modeled with MCNP for both the core and filter, as well ...
An accelerator-based BNCT facility is under construction at the Berkeley Lab. An electrostatic-quadrupole (ESQ) accelerator is under development for the production of neutrons via the {sup 7}Li(p,n){sup 7}Be reaction at proton energies between 2.3 and 2.5 MeV. A novel type of power supply, an air-core coupled transformer power supply, is being built for ...
The Soreq Applied Research Accelerator Facility (SARAF) is based on a superconducting linear accelerator currently being built at the Soreq research center (Israel). The SARAF is planned to generate a 2 mA 4 MeV proton beam during its first year of operation and up to 40 MeV proton or deuteron beam in 2012. The high intensity beam, together with the linac ability to adjust the ...
This dissertation describes a novel Boron Neutron Capture Therapy (BNCT) application for the treatment of human epidermal growth factor receptor type 2 positive (HER2+) breast cancers. The original contribution of the dissertation is the development of the engineering simulation and the feasibility study of the radiation treatment protocol for this novel combination of ...
synchrotrons, compact proton linacs for PET isotope production, epithermal neutron sources for the BNCT (PET and SPECT), the production of epithermal neutron beams for BNCT, and accelerated proton beams for the PET application, and neutron production for the BNCT application. These systems, with minor
... a potential dose-limiting toxicity for BNCT of brain tumors or head and neck tumors (48). Within this context, BNCT protocols that ... ...
The overall goal of this research is to combine two powerful methodologies, boron neutron capture therapy (BNCT) and positron emission tomography (PET), to advance the treatment of patients with malignant brain tumors. BNCT is a method to selectively deli...
This report presents a summary of accomplishments and highlights in the PBF/BNCT Program for January 1991. The report includes information on the BNCT brain tumor and melanoma research programs, technical support and modifications, PBF operations, a miles...
This report presents a summary of accomplishments and highlights in the PBF/BNCT Program for February 1991. The report includes information on the BNCT brain tumor and melanoma research programs, technical support and modifications, PBF operations, a mile...
This PBF/BNCT Program Monthly Bulletin is the primary vehicle for prompt national and international dissemination of research progress and the development status of tools essential for optimum BNCT clinical application. Accordingly, beginning with this is...
The relative merit of using a deterministic code to calculate dose distributions for BNCT applications were examined. The TORT discrete deterministic ordinated code was used in comparison to MCNP4A to calculate dose distributions for BNCT applications
For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be p...
Pilot innovative facility for neutron capture therapy was built at Budker Institute of Nuclear Physics, Novosibirsk. This facility is based on a compact vacuum insulation tandem accelerator designed to produce proton current up to 10 mA. Epithermal neutrons are proposed to be generated by 1.915 MeV protons bombarding a lithium target using (7)Li(p,n)(7)Be ...
A new 5SDH Tandem Pelletron from NEC was installed at the Lebanese Atomic Energy Commission, in order to have an analytical research laboratory using PIXE, PIGE, RBS and other techniques. This paper is mainly a description of the facility and its development during the past two years where different calibrations of the experimental set-up and various research projects in some ...
Experiments are being developed at the Triangle Universities Nuclear Laboratory to offer undergraduate physics majors laboratory experiences in the atmosphere of a frontier accelerator facility. These experiments differ from projects done by Undergraduate Research Assistants in that they are designed specifically for integration into the undergraduate curriculum as part of a ...
Innovative facility for neutron capture therapy has been built at BINP. This facility is based on compact vacuum insulation tandem accelerator designed to produce proton current up to 10mA. Epithermal neutrons are proposed to be generated by 1.915-2.5MeV protons bombarding a lithium target using (7)Li(p,n)(7)Be threshold reaction. In the article, ...
