In this work we present an optimized neutron beam shaping assembly for epithermal Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) and discuss the simulations leading to its design.
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NASA Astrophysics Data System (ADS)
Boron neutron capture therapy is an experimental binary cancer radiotherapy modality in which a boronated pharmaceutical that preferentially accumulates in malignant tissue is first administered, followed by exposing the tissue in the treatment volume to ...
National Technical Information Service (NTIS)
. Scott. The design and testing high power lithium target for accelerator-based boron neutron capture therapy. Research and Development in Neutron Capture Therapy, Eds.: W. Sauerwein, R. Moss, and A. Wittig . - , , . , . [1] B. Bayanov, et al. Accelerator based neutron ...
E-print Network
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer ce...
A pilot accelerator-based source of epithermal neutrons, which is intended for wide application in clinics for boron neutron capture therapy, has been constructed at the Budker Institute of Nuclear Physics (Novosibirsk). A stationary proton beam has been obtained and near-threshold neutron ...
We present a conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture theory (BNCT). The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produc...
Several accelerator-based neutron capture therapy applications are under development. These applications include boron neutron capture therapy for glioblastoma multiform and boron neutron capture synovectomy (BNCS) for rheumatoid arthritis. These modalities use ...
threshold for accelerator boron neutron capture therapy. Med. Phys. 27(1), 192�202 (2000). 11. Schmid, EAN ACCELERATOR-BASED NEUTRON MICROBEAM SYSTEM FOR STUDIES OF RADIATION EFFECTS Yanping Xu1 2010 A novel neutron microbeam is being developed at the Radiological Research Accelerator ...
lithium hydride layer needs dry gas medium. So, lithium nitride and lithium oxide are preferable because of neutron producing matter (hydride, nitride, oxide or fluoride of lithium) on the substrate. The active lithium targets with intense liquid cooling are used now for accelerator based boron ...
Boron Neutron Capture Therapy (BNCT) is being studied as a possible radiotherapic treatment for some cancer types. Neutron energy for penetrating into tissue should be in the epithermal range. Different methods are used for neutron production. Electron accelerators are an alternative way for producing ...
Current accelerator-based neutron source concepts for boron neutron capture therapy (BNCT) are centered on the lithium (p,n) reaction. The near lithium threshold source concept uses proton energies <~100 keV above the reaction threshold energy (1.88 MeV). For deeply seated brain tumors, epithermal (1 eV to 10 ...
Boron neutron capture therapy (BNCT) is a bimodal form of radiation therapy for cancer. The first component of this treatment is the preferential localization of the stable isotope {sup 10}B in tumor cells by targeting with boronated compounds. The tumor and surrounding tissue is then irradiated with a neutron beam ...
DOE Information Bridge
We present a conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture theory (BNCT). The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produced by the /sup 7/Li(p,n)/sup 7/Be reaction. A liquid lithium ...
A conceptual design of a beam-shaping assembly for boron neutron capture therapy using deuterium-tritium accelerator based neutrons source is developed. Calculations based on a simple geometry model for the radiation transport are initially performed to estimate the assembly materials and their ...
PubMed
A novel application of the 10B(n, (alpha) )7Li nuclear reaction for the treatment of rheumatoid arthritis is under development. this application, called Boron Neutron Capture Synovectomy (BNCS), is briefly described here and the differences between BNCS and Boron Neutron Capture Therapy (BNCT) are discussed in ...
In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the {sup 7}Li(p, n){sup 7}Be reaction by ...
In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the 7Li(p, n)7Be reaction by irradiating a thick ...
A source for boron neutron capture therapy (BNCT) comprises a body of photoneutron emitter that includes heavy water and is closely surrounded in heat-imparting relationship by target material; one or more electron linear accelerators for supplying electron radiation having energy of substantially 2 to 10 MeV and for impinging such radiation on the target ...
DOEpatents
In one embodiment there is provided an application of the {sup 10}B(n,{alpha}){sup 7}Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than ...
Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H{sup +} yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the ...
In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than ...
In vitro studies using boron-labeled antibodies and elemental boron as neutron target in therapy for
NASA Technical Reports Server (NTRS)
Monte Carlo modelling of an irradiation facility, for boron neutron capture therapy (BNCT) application, using a set of advanced type, accelerator based, 3H(d,n)4He (D-T) fusion neutron source device is presented. Some general issues concerning the design of a proper irradiation beam shaping ...
Accelerator-based neutron sources are an attractive alternative to nuclear reactors for providing epithermal neutron beams for Boron Neutron Capture Therapy. Based on clinical requirements and neutronics modeling the use of proton and deuteron induced reactions in {sup 7}Li ...
The Peking University Neutron Imaging Facility (PKUNIFTY) is a Radio Frequency Quadruple (RFQ) accelerator based system. The fast neutrons are produced by 2 MeV deuterons bombarding beryllium target. The moderator, reflector, shielding and collimator have been optimized with Monte-Carlo simulation to improve the ...
... Accession Number : AD0299648. Title : THE NEUTRON METHOD OF ANALYSIS FOR BORON IN SKARN ORES. Corporate ...
DTIC Science & Technology
Neutrons can be produced with low-energy ion accelerators for many applications, such as the characterisation of neutron detectors, the irradiation of biological samples and the study of the radiation damage in electronic devices. Moreover, accelerator-based neutron sources are under development for ...
This volume contains the proceedings of the 3rd Workshop on 'the Boron Chemistry and Boron Neutron Capture Therapy' held on February 12, in 1991. In this workshop, our attention was focused on the chemical nature of boron compounds and the boron neutron c...
A new conceptual design for an accelerator-based boron neutron capture therapy (ABNCT) facility based on the high-current low-energy proton beam driven by the linear accelerator at SARAF (Soreq Applied Research Accelerator Facility) incident on a windowless forced-flow liquid-lithium target, is described. The liquid-lithium target, currently in ...
A numerical optimization of a Beam Shaping Assembly (BSA) for Accelerator Based-Boron Neutron Capture Therapy (AB-BNCT) has been performed. The reaction (7)Li(p,n)(7)Be has been considered using a proton beam on a lithium fluoride target. Proton energy and the dimensions of a simple BSA geometry have been varied to obtain a set of ...
... Descriptors : *BORON, *NEUTRON FLUX, *THERMAL NEUTRONS, MEASUREMENT, ENVIRONMENTS, CALIBRATION, HEAT FLUX ...
The development and evaluation of a new approach to neutron brachytherapy is described. This approach, accelerator-based fast neutron brachytherapy, involves the interstitial or intracavity insertion of a narrow, evacuated accelerator beam tube such that its tip, containing the neutron-producing target, is placed ...
... DAMAGE, *THERMAL NEUTRONS, DEGRADATION, GAIN, GEOMETRY, DOPING, EMITTERS, BORON, FAST NEUTRONS, NEUTRON CAPTURE ...
... that are epithermal neutrons and provide low-energy neutron energy particularly suited for Boron Neutron Capture Therapy (BNCT) treatment. ...
In the framework of an advanced Exotic Ion Beam facility, named SPES (Study and Production of Exotic Species), that will allow a frontier program both in nuclear and interdisciplinary physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma ...
In the framework of an advanced Exotic Ion Beam facility project, named SPES (Study and Production of Exotic Species), that will allow a frontier program in Nuclear and Interdisciplinary Physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma ...
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by {sup 10}B energetic ...
At Kyoto University Research Reactor Institute (KURRI), 275 clinical trials of boron neutron capture therapy (BNCT) have been performed as of March 2006, and the effectiveness of BNCT has been revealed. In order to further develop BNCT, it is desirable to supply accelerator-based epithermal-neutron sources that can ...
This is the progress report and proposed research objectives for the project entitled An Accelerator Neutron Source for BNCT.'' The progress report is for the time period from July 15, 1990 to date. The proposal is for the upcoming budget period from July 15, 1991 to July 14, 1992. The objectives of this project are to design and test the target assembly ...
The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.
The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings
Oak Ridge National Laboratory Physics Division The Oak Ridge Electron Linear Accelerator Pulsed Neutron Source The ORELA is a powerful electron accelerator-based neutron source...
Science.gov Websites
This volume contains the proceedings of the 5th Workshop on 'the Boron Chemistry and Boron Neutron Capture Therapy' held on February 22 in 1993. The solubility of the boron carrier play an important role in the BNCT. New water-soluble p-boronophenylalanin...
The development of Boron Neutron Capture Therapy (BNCT) has been progressing in both ^{10 }B compound development and testing and neutron beam delivery. Animal tests are now in progress with several ^{10}B compounds and once the results of these animal tests are promising, patient trials can be initiated. The objective of this study is ...
for neutron capture therapy is under construction now at the Budker Institute of Nuclear Physics, NovosibirskAccelerator based neutron source for neutron capture therapy B. Bayanov, Yu. Belchenko, V. Belov, V Physics, Novosibirsk, Russia The Budker Institute of Nuclear Physics (Novosibirsk) and ...
Boron neutron capture synovectomy (BNCS) has been proposed as a new application of the boron neutron capture reaction for the treatment of rheumatoid arthritis. In BNCS, a boron compound is injected into the joint space, where it is taken up by the synovium. The joint is then irradiated with ...
To realize the accelerator-based boron neutron capture therapy (BNCT) at the Cyclotron and Radioisotope Center of Tohoku University, the feasibility of a cyclotron-based BNCT was evaluated. This study focuses on optimizing the epithermal neutron field with an energy spectrum and intensity suitable for BNCT for various combinations of ...
Recent interest in the production of epithermal neutrons for use in boron neutron capture therapy (BNCT) has prompted an investigation into the feasibility of generating such neutrons with a tandem cascade accelerator. Accelerator-produced neutrons in the...
The Apollo 17 Lunar Neutron Probe Experiment measured both the boron-10 neutron capture rate and the
The {sup 7}Li(p,n){sup 7}Be reaction has been investigated as an accelerator-driven neutron source for proton energies between 2.1 and 2.6 MeV. Epithermal neutron beams shaped by three moderator materials, Al/AlF{sub 3}, {sup 7}LiF, and D{sub 2}O, have been analyzed and their usefulness for boron neutron capture ...
This volume contains the proceedings of the 4th Workshop on 'the Boron Chemistry and Boron Neutron Capture Therapy' held on February 24 in 1992. First, clinical experiences of BNCT in the Kyoto University Research Reactor in 1992 were briefly reported. Th...
In Boron Neutron Capture Therapy (BNCT) the dominant dose delivered to the tumor is due to (alpha) and (sup 7)Li charged particles resulting from a neutron capture by (sup 10)B and is referred to herein as the boron dose. Boron dose is directly attributab...
In Boron Neutron Capture Therapy (BNCT) of malignant brain tumors, the energy dependence of a clinically relevant Relative Biological Effectiveness (RBE) for epithermal neutrons, RBE(En), is important in neutron field design. In the first half of this paper, we present the development of an expression for the ...
... Accession Number : AD0276926. Title : THE EFFECT OF BORON-10 SHIELDS ON THE CALIBRATION OF NEUTRON-THRESHOLD DETECTORS. ...
... Accession Number : ADD251306. Title : Swelling and Microcracking of Boron Carbide Subjected to Fast Neutron Irradiations. ...
Thick lithium targets are excellent sources of neutrons for accelerator boron neutron capture therapy (BNCT), but the low melting point of lithium (181 deg. C) and a need for high proton currents make target heating a concern. However, because neutrons are not produced for proton energies below the {sup ...
A program is under development at the Idaho National Engineering Laboratory (INEL) that involves using the Power Burst Facility (PBF) for research into Boron Neutron Capture Therapy (BNCT). BNCT utilizes the ionizing energy from boron-neutron capture to s...
The two-channel neutron boron meter is a continuous on-line measuring device to measure boron concentration of primary cooling liquid of reactors. The neutron-leakage-compensation method is taken in the measuring mechanism. In the primary measuring config...
Boron Neutron Capture Therapy (BNCT) is a binary method of cancer therapy based on the capture of neutrons by a boron-l0 atom. Cytotoxic (sup 7) Linuclei and alpha-particles are emitted, with a range in tissue of 9 and 5 micrometers, respectively, about o...
The technologies that are being utilized to design and build the target systems for a state-of-the-art accelerator-based neutron source, the Spallation Neutron Source (SNS), are discussed. Emphasis is given to the technology issues that present the greate...
... Results for silicone based rubbers, impregnated with elemental boron or boron carbide, Boron-silicone 236 and Bisco NS-I respectively are ...
... Title : The Microlocalization of Boron by Neutron Capture Radiography, After ... Personal Author(s) : Laurent-Pettersson, M. ; Chauzy, C. ; Girard, N ...
Uranium-aluminum alloys in which boron is homogeneously dispersed by adding it as a nickel boride are described. These compositions have particular utility as fuels for neutronic reactors, boron being present as a burnable poison.
... Accession Number : ADA192306. Title : NDP (Neutron Depth Profiling) Evaluations of Boron-Implanted Compound Semiconductors,. ...
... Energy Distribution in the Nucleus for Different Neutron Spectra (Proton Recoil) and Concentration Distributions (Boron and Nitrogen Capture ... ...
NBII National Biological Information Infrastructure
There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). Progress on an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator for Accelerator-Based (AB)-BNCT ...
Measurements are reported of the neutron collimating properties of single and triple boron fibre laminates in aluminium. The results show that slit packages containing these materials can be used as neutron collimators or choppers up to neutron energies a...
Clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumors had been carried out for half a decade, using an epithermal neutron beam at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 ...
The operational characteristics of a boron thermopile for slow neutron detection were investigated. It was determined that the instrument is not useful as a neutron detector because of its low sensitivity to thermal neutrons and its large response to variations in ambient temperature. (auth)
Recent advances in the development of boron pharmaceuticals have reopened the possibility of using epithermal neutrons to treat brain tumors containing boron-10. This paper summarizes the approaches being used to generate the neutron sources and identifie...
Recent advances in the development of boron pharmaceuticals have reopened the possibility of using epithermal neutrons to treat brain tumors containing boron-10. This paper summarizes the approaches being used to generate the neutron sources and identifies specific areas where more research and development are ...
In the framework of future Boron Neutron Capture Therapy (BNCT) experiments, where cells and animals irradiations are planned at the research reactor of Strasbourg University, the feasibility to obtain a suitable epithermal neutron beam is investigated. T...
A new multi-modal Monte-Carlo radiotherapy planning system (developing code: JCDS-FX) is under development at Japan Atomic Energy Agency. This system builds on fundamental technologies of JCDS applied to actual boron neutron capture therapy (BNCT) trials in JRR-4. One of features of the JCDS-FX is that PHITS has been applied to particle transport ...
... when welding polymeric materials with thermal ... HALOCARBON PLASTICS, BONDING, THERMAL NEUTRONS, NEUTRON BEAMS, BORON ...
A neutron detector using crystalline rhombohedral boron phosphides having a boron-to-phosphorus ratio of at least 6 to 1 as the sensing element is described. The preparation of boron phosphides is discussed and 9 examples are given. The boron phosphide gives a varying resistance in ...
At BNL, we have evaluated the beam current required to produce a clinical neutron beam for Boron Neutron Capture Therapy (BNCT) with an epithermal neutron flux of 10{sup 12} n/cm{sup 2}/hr. Experiments were carried out on a Van de Graaff accelerator at the Radiological Research Accelerator Facility (RARAF) at ...
The resurgence of interest in boron neutron capture therapy (BNCT) as a treatment for malignant lesions has resulted in the synthesis of numerous boron compounds as candidates for clinical use. The model presented herein provides a rapid, quantitative, an...
A boron-10 containing reactor control element wherein the boron-10 is dispersed in a matrix material is describeri. The concentration of boron-10 in the matrix varies transversely across the element from a minimum at the surface to a maximum at the center of the element, prior to exposure to neutrons. (AEC)
This report describes recent neutron depth profiling (NDP) experiments on the distribution of implanted boron in several semiconductors. The objectives are to compare the boron profiles for different materials that had been simultaneously implanted and to...
... boronated drug(s) and subsequent activation by neutrons. Brain tumors, skin melanoma, and tumors of head and neck have been treated with BNCT. Boron carrier drugs ... ...
... the threshold for pneumonitis in healthy human lung. MATERIALS AND METHODS Boron Analysis The boron concentration in liquid or solid tissue samples was determined using the prompt γ-ray neutron activati...
The single most difficult problem yet to be solved for effective clinical use of boron neutron capture therapy (BNCT) in the United States is the development of highly tumor-selective third generation boron compounds. In this context, the boronated amino ...
... Its relation to quiescent cell population and tumor cure in neutron capture ... therapy. Cancer Lett 187:135�141.2002). CrossRef, PubMed, CSACoons, ... ...
... SYNTHESIS(CHEMISTRY), *BORON COMPOUNDS ... SPECTRA, THERAPY, INFRARED ... COMPOUNDS, NEUTRON CAPTURE, CHEMICAL ...
of detectors - including Boron Neutron Capture Therapy (BNCT) Physics STEM simulation of cluster structures
... attempt to find a material or materials sensitive to ... REACTIONS, DAMAGE, DAMAGE, GLASS, THERMAL NEUTRONS, ATTENUATION, BORON ...
applications: the development of a Boron Neutron Capture Therapy (BNCT) installation to perform research
