Research on Information Systems (IS) acceptance is substantially focused on extrinsic motivation in workplaces, little is known about the underlying intrinsic motivations of Hedonic IS (HIS) acceptance. This paper proposes a hybrid HIS acceptance model which takes the unique characteristics of HIS and multiple ...

Recent empirical research has utilized the Technology Acceptance Model (TAM) to advance the understanding of doctors' and nurses' technology acceptance in the workplace. However, the majority of the reported studies are either qualitative in nature or use small convenience samples of medical staff. Additionally, in ...

In this study, we present a revised Technology Acceptance Model (TAM) for measuring users` attitude towards adoption of Decision Support Systems (DSS). We present the model developed, as well as initial results from a survey at a Greek bank`s target users group for the evaluation of a novel DSS. Our aim, except the ...

The rapid growth of virtual communities (VCs) on the Internet raises important research questions regarding the antecedents of satisfaction and loyalty in VCs. This study compared the technology acceptance model (TAM), Seddon Information Systems Success Model (Seddon model), and an integrated ...

The purpose of this study is to examine pre-service teachers' attitudes to computers. This study extends the technology acceptance model (TAM) framework by adding subjective norm, facilitating conditions, and technological complexity as external variables. Results show that the TAM and subjective norm, facilitating ...

Increasing interest in end users� reactions to health information technology (IT) has elevated the importance of theories that predict and explain health IT acceptance and use. This paper reviews the application of one such theory, the Technology Acceptance Model (TAM), to health care. We reviewed 16 data sets ...

The industry standard method used to validate finite element models involves correlation of test and analysis mode shapes using reduced Test-Analysis Models (TAMs). Some organizations even require this model validation approach. Considerable effort is required to choose sensor locations and to create a suitable ...

The Technology Acceptance Model (TAM) represents how users come to accept and use a given technology and can be applied to teachers' use of educational technologies. Here the model is extended to incorporate teachers' perceived usability and self-efficacy measures toward the technologies they ...

The purpose of this research is to explore enterprises' acceptance of Audience Response System (ARS) using Technology Acceptance Model (TAM). The findings show that (1) IT characteristics and facilitating conditions could be external variables of TAM. (2) The degree of E-business has positive ...

The success of a virtual learning environment (VLE) depends to a considerable extent on student acceptance and use of such an e-learning system. After critically assessing models of technology adoption, including the Technology Acceptance Model (TAM), TAM2, and the Unified ...

The main objective of this paper is to examine cultural differences and technology acceptances from students of two universities, one is from a European country: Spain, and the other is in Latin America: Chile. Both of them provide their students with e-learning platforms. The technology acceptance model (TAM) and ...

Purpose: The purpose of this study is to assess the efficiency of the technology acceptance model (TAM) to explain pre-service teachers' intention to use technology in Turkey. Design/methodology/approach: A total of 197 pre-service teachers from a Turkish university completed a survey questionnaire measuring their responses to four ...

Wireless network technologies present unique opportunities and challenges for businesses, and Small & Medium Enterprises (SMEs) are no exception. Recently Vankatesh et al. (2003) proposed a more complete model for the understanding of the acceptance and adoption of Information Technology. Their model builds upon and extends beyond ...

Implementing information systems (IS) is expensive and sometimes unsuccessful due to low levels of system user acceptance (Legris, Ingham, & Collerette, 2003). For this reason, IS research has focused, in part, on variables contributing to system user acceptance of technology. As a part of this effort, Davis (1989) theorized and tested the technology ...

We examined the main factors affecting the intention of physicians to use teledermatology using a modified Technology Acceptance Model (TAM). The investigation was carried out during a teledermatology pilot study conducted in Spain. A total of 276 questionnaires were sent to physicians by email and 171 responded (62%). Cronbach's alpha ...

This study extended the Technology Acceptance Model (TAM) by examining the roles of two aspects of e-resource characteristics, namely, information quality and system quality, in predicting public health students� intention to use e-resources for completing research paper assignments. Both focus groups and a questionnaire were used to ...

Institutions of higher education have increasing turned to web portals as a way to connect with students. These portals are designed to provide students a centralized point of access to information and services. In spite of the efforts put into developing and maintaining these portals, their use by students can be disappointing. The study described in this paper examines factors influencing the ...

Basically, neglecting the human factor is one of the main reasons for system failures or for technology rejection, even when important technologies are considered. Biometrics mostly have the characteristics needed for effortless acceptance, such as easiness and usefulness, that are essential pillars of acceptance models such as ...

This study examined pre-service teachers' self-reported behavioral intentions to use technology. Three hundred and fourteen participants completed a survey questionnaire measuring their responses to six constructs from a research model that extends the technology acceptance model (TAM) by including facilitating ...

calculation is highly sensitive to errors, so that the Static and IRS TAM models have a very small probability], and SEREP [8] reductions. The Modal, Hybrid, and SEREP TAMs exactly predict the target modes, while the IRS Target Mode Number FEM Frequency (Hz) TAM Target Mode Number Static TAM ...

This study assesses the pre-service teachers' self-reported future intentions to use technology in Singapore and Malaysia. A survey was employed to validate items from past research. Using the Technology Acceptance Model (TAM) as a research framework, 495 pre-service teachers from Singapore and Malaysia responded to an 11-item ...

This study examined the influence of perceived enjoyment on pre-service teachers' intention to use technology, in addition to re-appraising the role of attitude toward use in the Technology Acceptance Model (TAM; Davis, Bagozzi, & Warshaw, 1989). One hundred and fifty-three participants in Singapore completed a survey questionnaire ...

A laboratory challenge model was developed to evaluate the effects of a natural M. cerebralis exposure on the susceptibility ... ...

Information technology acceptance has received much attention, but little research has been conducted to assess farmers� information adoption. Despite the importance of information, its value will not be realized if farmers are reluctant to accept it. This research aims to study farmers� information adoption in China, in order to provide some ...

Many universities implement e-learning for various reasons. It is obvious that the number of e-learning opportunities provided by higher educational institutes continues to grow in Korea. Yet little research has been done to verify the process of how university students adopt and use e-learning. A sample of 628 university students took part in the research. The structural equation ...

The present study was undertaken to investigate the antitumor effect of a combination of the antiestrogen tamoxifen (TAM) and either the antiprogestin onapristone (ON) or the progestogen megestrol acetate (MEG) in experimental mammary tumor models. Rats bearing DMBA- or NMU-induced mammary tumors were treated with ON or MEG either alone or in combination ...

The study uses the Technology Acceptance Model, the Diffusion of innovation model and constructs of trust, risk and personal innovativeness in order to build a model for teachers' adoption of e-governance in Greece. Primary and secondary education teachers responded to an online survey resulting to 230 ...

The effective development of a computer based assessment (CBA) depends on students' acceptance. The purpose of this study is to build a model that demonstrates the constructs that affect students' behavioral intention to use a CBA. The proposed model, Computer Based Assessment Acceptance Model ...

This study examined pre-service teachers' self-report on their attitude toward computer use. Participants were 285 pre-service teachers at a teacher training institution in Singapore. They completed a survey questionnaire measuring their responses to five constructs which formed a research model using the Technology Acceptance Model ...

Teachers use technology to provide different learning methods to cater to individual students' learning strengths and styles. In many school districts, teachers are critical stakeholders in the success of technology implementations. Successful technology initiatives depend on teachers' motivation, knowledge, and skills to implement and utilize job-related technologies. Many studies suggest that ...

This study looks at the usage of a course website among distance learning business management students in a public institution of higher learning in Malaysia. The Technology Acceptance Model (TAM) was used as the basis of the research framework but voluntariness was added as a possible moderating factor. TAM ...

Abstract: Unquestionably, more women should be encouraged to study computing technology and to become the high-tech professionals. Women do not yet equal in men in frequency of computer usage. Equally important, however, is the quality of women?s experience as users of information technology (IT). As more and more of global information comes from online sources, women unable or unwilling to use IT ...

Purpose: This paper aims to compare the pre-service teachers from Singapore and the UK on their self-reported attitude towards computer use (ATCU) by employing the technology acceptance model (TAM) as the research framework. Design/methodology/approach: In total, 395 pre-service teachers completed a survey questionnaire measuring their ...

This paper presents an exploratory study about the development of a structural and measurement model for the technological acceptance (TAM) of a web-based educational tool. The aim consists of measuring not only the use of this tool, but also the external variables with a significant influence in its use for planning future ...

The support systems for the Emergency Medical Services (EMS) in the mass gatherings, such as the local marathon or the large international baseball games, had been underdeveloped. The purposes for this study were to develop triage-based EMS Personal Digital Assistant (PDA) support systems for the mass-gatherings and to evaluate users' perceived ease of use and usefulness of the systems in terms of ...

ABSTRACT: This paper aims to predict consumer acceptance of e-commerce by proposing a set of key drivers for engaging consumers in on-line transactions. The primary constructs for capturing consumer acceptance of e-commerce are intention to transact and on-line transaction behavior. Following the theory of reasoned action (TRA) as applied to a ...

Mobile commerce (MC) refers to e-commerce activities carried out using a mobile device such as a phone or PDA. With new technology, MC will be rapidly growing in the near future. At the present time, what factors making consumer accept MC and what MC applications are acceptable by consumers are two of hot issues both for MC providers and f or MC ...

A number of studies have indicated that the successful pedagogical use of technology depends on teachers' attitudes and acceptance towards technology. In order to predict and understand teachers' technology use and acceptance, a well-defined framework is essential. The purpose of the present paper attempts to explore a model to ...

Web Course Tools (WebCT) have enhanced the ability and motivation of institutes of higher education to support e-learning. In this study, we extended the Technology Acceptance Model to include technical support as a precursor and then investigated the role of the extended model in user acceptance of WebCT. ...

... scale. The other approach is based on the Target Acquisition Model (TAM) based on Johnson's criteria and a set of tasks. ...

The stochastic model theory of TAM (1987, 1989) for broadband shock associated noise was extended to

This research aims to explore the factors that affect the intention to use in Social Networking Sites (SNS). We apply the theory of Technology Acceptance Model (TAM), intrinsic motivation, and trust properties to develop the theoretical framework for SNS users' intention. The results show that the important factors influencing SNS ...

Scope and method of study: The purpose of this study was to investigate the determinants of mobile learning acceptance in higher education. Mobile learning is a rapidly growing method of learning that utilizes mobile devices to deliver content. Acceptance of mobile learning theory was derived from technology acceptance theories. The ...

The support systems for the Emergency Medical Services (EMS) at mass gatherings, such as the local marathon or large international baseball games, are underdeveloped. The purposes of this study were to extend well-developed, triage-based, EMS Personal Digital Assistant (PDA) support systems to cover pre-hospital emergency medical services and onsite evaluation forms for the mass gatherings, and to ...

Previous studies showed that flaxseed lignan (secoisolariciresinol diglucoside, SDG) and oil (FO) inhibit established breast tumor growth in athymic mice with or without tamoxifen (TAM) treatment. TAM was found to increase bone mineral content (BMC) and density (BMD) in breast cancer patients. It is not known whether SDG or FO alone or combined with ...

The Technology Acceptance Model (TAM) represents an important theoretical contribution toward understanding IS usage and IS acceptance behaviors [6, 19]. However, as noted by several IS researchers [cf: 4, 5, 6, 9, 14], TAM is incomplete in one important respect: it doesn't account for social ...

Free and open source software (FOSS) movement essentially arises like answer to the evolution occurred in the market from the software, characterized by the closing of the source code. Furthermore, some FOSS characteristics, such as (1) the advance of this movement and (2) the attractiveness that contributes the voluntary and cooperative work, have increased the interest of the users towards free ...

Usefulness and ease of use proved to be key determinants of the acceptance and usage of e-learning. On the contrary, little is known about students' perceptions in a blended learning setting. In this paper, the Technology Acceptance Model (TAM) was utilised, in order to investigate Greek university students' ...

Objective:To investigate older people�s acceptance of e-health services, in order to identify determinants of, and barriers to, their intention to use e-health.Method:Based on one of the best-established models of technology acceptance, Technology Acceptance Model (TAM), ...

Resistance to tamoxifen (TAM) and aromatase inhibitors represents a major drawback to the treatment of hormone-dependent breast cancer, and strategies to overcome this problem are urgently needed. The anti-diabetic biguanide metformin (MF) exerts pleiotropic effects which could enhance the effectiveness of available hormonal therapies. This study modeled ...

Objective.?To assess the applicability of the Technology Acceptance Model (TAM) constructs in explaining HIV case managers' behavioural intention to use a continuity of care record (CCR) with context-specific links designed to meet their information needs. Design.?Data were collected from 94 case managers who provide care to persons ...

Very old people accumulate the "handicaps": social, physical, psychological or cognitive. Various research thus developed to determine there waiting and needs and also to see the benefit possibly produced by technologies (called ?gerontechnology?) on their living conditions. The object of this article is to present the numerical service offer to very old perople and to see how it takes part in a ...

Consulting Ltd, Mauritius. His areas of interest are business strategy & management. This study explores the impact of perceived security and privacy on the intention to use Internet banking. An extended version of the technology acceptance model (TAM) is used to examine the above perception. A survey was distributed, the 187 ...

A 2D model is introduced to study the onset of parametric surface waves, their secondary instabilities, and the transition to spatiotemporal chaos. We obtain the stability boundary of a periodic standing wave above onset against Eckhaus, zigzag, and transverse amplitude modulations (TAM), as a function of the control parameter [var epsilon] and the ...

Many organisations and institutions have integrated learning objects into their e-learning systems to make the instructional resources more efficient. Like any other information systems, this trend has made user acceptance of learning objects an increasingly critical issue as a high level of learner satisfaction and acceptance reflects that the users are ...

ABSTRACT: BACKGROUND: Tumor-associated macrophages (TAMs) are the most abundant immune cells within the tumor stroma and play a crucial role in tumor development. Although clinical investigations indicate that high levels of macrophage infiltration into tumors are associated with a poor prognosis, the exact role played by TAMs during tumor development ...

Although e-learning has been prompted to various education levels, the intention to continue using such systems is still very low, and the acceptance-discontinuance anomaly phenomenon (i.e., users discontinue using e-learning after initially accepting it) is a common occurrence. This paper synthesizes the expectation-confirmation model ...

The application of scientific tools to analyse the use of Internet-based e-learning tools in academic settings is in general an ignored area. E-learning tools are actually an emergent topic as a result of the new ideas introduced by the European Higher Education Area. Lifelong learning, or the promotion of student initiative, is the new paradigm of a learner-centred education. In this context, ...

... gap mammal habitat model for the Red squirrel (Tamiasciurus hudsonicus); 90 meter resolution University Park, ... a potential habitat model for the Red squirrel (Tam...

... MODELS, WEAPON SYSTEMS, ACCURACY ... RESOLUTION, NOWCASTING, TIME DEPENDENCE ... INTERFACE, REAL TIME, INTERPOLATION. ...

BackgroundPatients are no longer passive recipients of health care, and increasingly engage in health communications outside of the traditional patient and health care professional relationship. As a result, patient opinions and health related judgements are now being informed by a wide range of social, media, and online information sources. Government initiatives recognise self-delivery of health ...

Renren and Kaixin, which are Chinese versions of "Facebook", are the main Social Network Sites (SNSs) in China. Although many researchers have been exploring SNSs usage and have gained rich results, there are limited studies for the understanding of SNSs usage in China. In this present study, with 777 Chinese participants, we test variables influencing Chinese SNSs usage based on the technology ...

The primary questions addressed in this paper are the following: what are the factors that affect students' adoption of an e-learning system and what are the relationships among these factors? This paper investigates and identifies some of the major factors affecting students' adoption of an e-learning system in a university in Jordan. E-learning adoption is approached from the information systems ...

The first aim of the present study is to validate an extended technology acceptance model (TAME) on the data derived from the faculty members of a university in an ongoing, computer mediated work setting. The study extended the original TAM model by including an intrinsic motivation component--computer self ...

Cloud computing is gaining popularity in higher education settings, but the costs and benefits of this tool have gone largely unexplored. The purpose of this study was to examine the factors that lead to technology adoption in a higher education setting. Specifically, we examined a range of predictors and outcomes relating to the acceptance of a cloud computing platform in ...

UDP-glucuronosyltransferase (UGT) 1A4-catalyzed glucuronidation is an important drug elimination pathway. Although atypical kinetic profiles (nonhyperbolic, non-Michaelis-Menten) of UGT1A4-catalyzed glucuronidation have been reported occasionally, systematic kinetic studies to explore the existence of multiple aglycone binding sites in UGT1A4 have not been conducted. To this end, two positional ...

UDP-glucuronosyltransferase (UGT) 1A4-catalyzed glucuronidation is an important drug elimination pathway. Although atypical kinetic profiles (nonhyperbolic, non-Michaelis-Menten) of UGT1A4-catalyzed glucuronidation have been reported occasionally, systematic kinetic studies to explore the existence of multiple aglycone binding sites in UGT1A4 have not been conducted. To this end, two positional ...

... Upgrades to the TEDS database were consolidated with a major upgrade to achieve DII/COE (Defense Information Infrastructure/Common ...

A method based on the work of Tam and Tanna (1982) for calculating the near field noise spectrum and

... (in press) Alkon, D. L., Vogl, T. P, Blackwell, KT and Tam, DC (1991) Memory function in neural and artificial networks. In: Neural Network Models of ...

The considerable level of investigation into information systems and technology acceptance and diffusion to date has witnessed the use of an extensive range of exploratory techniques examining numerous diverse systems and technologies in a myriad of different contexts. The aim of this paper is to provide a comprehensive and systematic review of the literature relating to such ...

Following up a previous study that examined public health students� intention to use e-resources for completing research paper assignments, the present study proposed two models to investigate whether or not public health students actually used the e-resources they intended to use and whether or not the determinants of intention to use predict actual use of e-resources. ...

Business managers who look for ways to cut costs face difficult questions about the efficiency and effectiveness of software engineering practices that are used to complete projects on time, on specification, and within budget (Johnson, 1995; Lindstrom & Jeffries, 2004). Theoretical models such as the Theory of Reasoned Action (TRA) have linked intention and attitude to ...

OBJECTIVE: This paper is an exploratory study that investigates Singaporean women's acceptance of using mobile phones to seek health information. METHOD: A mobile web containing health topics was developed to track Singaporean women's actual use of their mobile phones to seek health information. A survey questionnaire measured variables hypothesized to predict Behavioural ...

A conceptual model for Information Communication Technology (ICT) adoption by Small Medium Enterprises (SMEs) is proposed. The research uses several ICT adoption models as its basis with theoretical underpinning provided by the Diffusion of Innovation theory and the Technology Acceptance Model ...

In this exploratory study, Internet adoption decisions are examined from an organizational perspective. We postulate that when the technology considered for adoption demands a shift of paradigm, involves support of a corporate-wide infrastructure, and/or nascent skills of technology developers, individual-based technology adoption models may lack explanation power. This study ...

Compared with course management software (e.g. Blackboard and WebCT), the content and technology offered by a textbook website (TBW) is relatively costless to universities and professors, and is a potentially valuable tool that can be leveraged to help students learn course material. The present study uses the extended Technology Acceptance Model ...

Understanding human-system response is critical to being able to plan and predict mission success in the modern battlespace. Commonly, human reliability analysis has been used to predict failures of human performance in complex, critical systems. However, most human reliability methods fail to take culture into account. This paper takes an easily understood state of the art human reliability ...

Chemopreventive effects were analysed of antioestrogen TAM and of MEL on NMU- or DMBA-induced mammary gland cancer, respectively, in female Sprague-Dawley rats. NMU was administered intraperitoneally in two doses each of 50 mg/kg b.w. between 46th-57th postnatal days. DMBA was given by gavage in one dose (20 mg per animal) between 50th-54th postnatal days. The treatment with ...

BackgroundThioredoxin 80 (Trx80) is an 80 amino acid natural cleavage product of Trx, produced primarily by monocytes. Trx80 induces differentiation of human monocytes into a novel cell type, named Trx80-activated-monocytes (TAMs).Principal FindingsIn this investigation we present evidence for a role of TAMs in the control of intracellular bacterial ...

Tumor-associated macrophages (TAMs) are frequently found in glioblastomas and a high degree of macrophage infiltration is associated with a poor prognosis for glioblastoma patients. However, it is unclear whether TAMs in glioblastomas promote tumor growth. In this study, we found that folate receptor beta (FR beta) was expressed on macrophages in human ...

The TAM family of receptors is preferentially expressed by professional and non-professional phagocytes, including macrophages, dendritic cells and natural killer cells in the immune system, osteoclasts in bone, Sertoli cells in testis, and retinal pigmental epithelium cells in the retina. Mutations in the Mertk single gene or in different combinations of the double or triple ...

Critical thinking skills are crucial for both academic and everyday life. This paper presents the author's Text Analysis Matrix (TAM), a model for developing skills for the critical examination of texts. The TAM guidelines involve finding and clarifying the main claims of a text, discovering and assessing arguments, uncovering the ...

The Transantarctic Mountains (TAM) are the highest and longest rift-related Cenozoic mountain range of our planet. Models for the evolution of the East Antarctic Ice Sheet (EAIS) state that, during post-late Eocene cooling local glaciers and ice caps nucleated on the highlands of the East Antarctic craton, including the proto-TAM. ...

The vitamin E analogue {alpha}-tocopheryl succinate ({alpha}-TOS) is an efficient anti-cancer drug. Improved efficacy was achieved through the synthesis of {alpha}-tocopheryl maleamide ({alpha}-TAM), an esterase-resistant analogue of {alpha}-tocopheryl maleate. In vitro tests demonstrated significantly higher cytotoxicity of {alpha}-TAM towards cancer ...

The purpose of this work was to determine the hormone dependence of mammary tumors induced in Sprague-Dawley rats by three intraperitoneal injections of N-nitroso-N-methylurea at 50, 80, and 110 days of age. Two experimental designs were carried out: (a) Ten days before the first NMU injection, 130 rats were divided into 13 batches and randomly assigned to the following treatments: control, ...

Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs) promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor cell invasion, matrix remodeling, and immune suppression against the tumor. In this study, we examined late-stage mammary tumors from a transgenic mouse model of ...

In the current study, the Distance Education Student Satisfaction Model, estimated as a structural equation model, is proposed to understand better what predicts student satisfaction from online learning environments. In the present study, the following variables are employed based on the Technology Acceptance ...

, particularly their extinction coefficient profile, are important in the radiation budget and hence climate modelled (right) to retrieve a profile of extinction coefficient (left). An optical depth of 15.5 + 10 vector, x � extinction coefficient profile. Have: observation vector, y � apparent backscatter

All Classes. Packages nom.tam.fits � nom.tam.fits.test � nom.tam.fits.utilities � nom.tam.image � nom.tam.util � nom.tam.util.test ...

Businesses and other organizations are relying increasingly on virtual teams to perform a range of business activities. A key challenge in utilizing virtual teams is to support collaboration among team members who are separated by distance and/or time. In this paper we use a research model based on a combination of the Technology Acceptance ...

An online learning community enables learners to access up-to-date information via the Internet anytime--anywhere because of the ubiquity of the World Wide Web (WWW). Students can also interact with one another during the learning process. Hence, researchers want to determine whether such interaction produces learning synergy in an online learning community. In this paper, we take the Technology ...

The estrogen receptor (ER) is a ligand-dependent transcription factor containing two transcriptional activation domains. AF-1 is in the N terminus of the receptor protein and AF-2 activity is dependent on helix 12 of the C-terminal ligand-binding domain. Two point mutations of leucines 543 and 544 to alanines (L543A, L544A) in helix 12 minimized estrogen-dependent transcriptional activation and ...

This study examines the effects that individual personality traits have on technology acceptance. Previous research on technology acceptance focuses primarily on exogenous variables such as trustor�s perceptions, attitudes, computer anxiety, positive or negative affect, age, and experience. This research seeks to improve our understanding of technology ...

Annual decisions concerning procurement of aircraft, munitions, and spare parts are of enormous interest to senior military decisionmakers. Currently the Air Force uses the Theater Attack Model (TAM), a large-scale linear program, to evaluate theater leve...

This report discusses the theory of tank gun accuracy and the Tank Accuracy Model (TAM) software for generating accuracy data. It is designed for those who produce and use such data for current weapon systems as well as for those who wish to analyze futur...

R.C. Hendricks, NASA Lewis Research Center; L.T. Tam and A. Przekwas, CHAM, ... A multidimensional, nonorthogonal, body-fitted-grid fluid flow model is ...

Thermostats have "set-points" that engineers design with mathematical rigor. Work in this issue of Cell Metabolism (Tam et al., 2009) applies similar modeling strategies to explore the control of murine energy and body weight homeostasis by leptin. PMID:19117539

Tumor-associated macrophages (TAM) are very abundant in tumors and are thought to play a major role in promoting tumor growth. The generation of TAM is positively regulated by several cytokines, including colony stimulating factor-1 (CSF-1) and monocyte chemoattractant protein-1 (CCL2). However, endogenous factors that suppress the generation of ...

Tumor-associated macrophages (TAMs) may have an important role in tumor immunity. We studied the activation state of TAMs in cutaneous SCC, the second most common human cancer. CD163 was identified as a more abundant, sensitive, and accurate marker of TAMs when compared with CD68. CD163(+) TAMs produced protumoral ...

BackgroundTumor-associated macrophages (TAMs) are the most abundant immune cells within the tumor stroma and play a crucial role in tumor development. Although clinical investigations indicate that high levels of macrophage (M?) infiltration into tumors are associated with a poor prognosis, the exact role played by TAMs during tumor development remains ...

The Cre-loxP system is a useful tool to study the physiological effects of gene knockout in the heart. One limitation with using this system in the heart is the toxic effect of chronic expression of the Cre recombinase. To circumvent this limitation, a widely used inducible cardiac-specific model, Myh6-MerCreMer (Cre), using tamoxifen (TAM) to activate Cre ...

There is increasing interest in phytoestrogens as potential alternatives to synthetic selective estrogen receptor modulators (SERMs) in the prevention and therapy of breast cancer. The present study is aimed at determining whether dietary glycine soya (Glycine max seeds; GS), which is rich in phytoestrogens, can enhance the anti breast cancer efficacy of the SERM tamoxifen ...

In this study, based on a 2-D thermomechanical finite element model, the uplift of the Transantarctic Mountains (TAM) is discussed in relation to the flexural uplift of a rheologically layered lithosphere, which is described by Vening-Meinesz's cantilever kinematics. The general model behaviour shows that the thickness of the crust and ...

In this exploratory study, we sought to examine the influence of mathematics teachers' beliefs on their intended and actual usage of dynamic mathematics software in their classrooms. The theory of planned behaviour (TPB), the technology acceptance model (TAM) and the innovation diffusion theory (IDT) were used to examine the influence ...

The West Antarctic Rift System (WARS) is one of the largest and most poorly understood continental rift systems. It is flanked by the Transantarctic Mountains (TAM), which extend for over 3,000 km from the Ross Sea Rift (RSR) to the Weddell Sea. Compared to other rift flanks the range is significantly higher, longer and wider. Unravelling the tectonic, climate and ice sheet ...

Enterprise Research Planning (ERP) software is advertised as the product that will "run the enterprise", improving data access and accuracy as well as enhancing business process efficiency. Unfortunately, organizations often make implementation decisions with little consideration for the maintenance phase of an ERP, resulting in significant recurring maintenance costs. Poor cost estimations are ...

The rapid development of information and communication technology and the popularization of the Internet have given a boost to digitization technologies. Since 2001, The National Science Council (NSC) of Taiwan has invested a large amount of funding in the National Digital Archives Program (NDAP) to develop digital content. Some studies have indicated that most respondents had no confidence in ...

PURPOSESomatostatin analogs act directly on breast cancer cells and indirectly on insulin and insulin-like growth factor 1 (IGF-1) levels. This trial was undertaken to assess whether octreotide would lower insulin and IGF-1 levels and reduce risk of breast cancer recurrence. PATIENTS AND METHODSThe NCIC CTG MA.14 (NCIC Clinical Trials Group MA.14) trial randomly assigned postmenopausal women to 5 ...

Purpose.To determine the distribution of tumor-associated macrophages (TAMs) during retinoblastoma tumor development, examine the contribution of bone marrow�derived TAMs in retinoblastoma tumors, and evaluate the supportive role of TAMs in tumor growth in a transgenic retinoblastoma mouse model.Methods.The time ...

... 469�470. Koprowski, J. L. 2005. Pine Squirrel (Tamiasciurus hudsonicus): a technical conservation assessment. USDA Forest Service, Rocky ... limitation and habitat preference of Glaucomys sabrinus and Tam...

Most public policy problems are �wicked�, being characterised by high complexity, many heterogeneous views and conflicts among various stakeholders. Therefore citizens interested to participate in such debates in order to be sufficiently informed should study large amounts of relevant material, such as reports, laws, committees� minutes, etc., which are in legalistic or in other specialist ...

As their populations age, many countries are facing the increasing economic pressure of providing healthcare to their people. In Taiwan, this problem is exacerbated by an increasing rate of obesity and obesity-related conditions. Encouraging the adoption of personal health management services is one way to maintain current levels of personal health and to efficiently manage the distribution of ...

The objective of this study was to investigate the effects of the dietary phytosterol beta-sitosterol (SIT) and the antiestrogen drug tamoxifen (TAM) on cell growth and ceramide (CER) metabolism in MCF-7 and MDA-MB-231 human breast cancer cells. The MCF-7 and MDA-MB-231 cell lines were studied as models of estrogen receptor positive and estrogen receptor ...

BackgroundMost bladder cancer patients experience lymphatic metastasis in the course of disease progression, yet the relationship between lymphangiogenesis and lymphatic metastasis is not well known. The aim of this study is to elucidate underlying mechanisms of how expanded lymphatic vessels and tumor microenvironment interacts each other and to find effective therapeutic options to inhibit ...

Meiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation. Here, we analyze the role of Arabidopsis thaliana SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA7 (SMG7), THREE DIVISION MUTANT1 (TDM1), and TARDY ASYNCHRONOUS MEIOSIS (TAM) in meiotic progression. SMG7 is a conserved nonsense-mediated ...

To test the hypothesis that tumor-associated macrophages (TAMs) enhance the growth and metastasis of human prostate cancer in the bone, we evaluated the effects of decreasing interleukin-6 (IL-6) production by tumor cells and TAMs in a mouse model of bone metastasis. Human PC-3MM2 cells that produce IL-6 were transfected with ...

ObjectiveThe Tailored Interventions for management of DEpressive Symptoms (TIDES) program was designed based on social cognitive theory to provide tailored, computer-based education on key elements and self-care strategies for depressive symptoms in persons living with HIV/AIDS (PLWHAs).Design and MeasurementBased on an extension of the Technology Acceptance ...

Tumor-associated macrophages (TAMs) encourage and coordinate neoplastic growth. In late stage human lung adenocarcinoma, TAMs exhibited mixed M1 (classical; argI^lowiNOS^high) and M2 (alternative; argI^highiNOS^low) polarization based on arginine metabolism. In several ...

P and S wave travel times from teleseismic earthquakes recorded by the Transantarctic Mountains Seismic Experiment (TAMSEIS) have been used to tomographically image upper mantle structure beneath portions of the Transantarctic Mountains (TAM), the East Antarctic (EA) craton, and the West Antarctic rift system (WARS) in the vicinity of Ross Island, Antarctica. The ...

by T.-Y. Tam in [Computing Iwasawa decomposition of a symplectic matrix by Cholesky factorization, Appl decomposition of a symplectic matrix Michele Benzi, Nader Razouk Department of Mathematics and Computer Science 2006; accepted 20 April 2006 Abstract We consider the computation of the Iwasawa decomposition

... Title : ACCEPTANCE TEST OF FREQUENCY CONVERSION OF THE EXPERIMENTAL MODEL OF SPERRY RADIO DOPPLER CHRONOGRAPH. ...

Mobile learning has recently become noteworthy because mobile devices have become popular. To construct an asynchronous learning forum on mobile devices is important because an asynchronous learning forum is always an essential part of networked asynchronous distance learning. However, the input interface in handheld learning devices, which is generally handwritten, is not efficient. Hence, most ...

The baby's crying is his most important mean of communication. The crying monitoring performed by devices that have been developed doesn't ensure the complete safety of the child. It is necessary to join, to these technological resources, means of communicating the results to the responsible, which would involve the digital processing of information available from crying. The survey carried out, ...