The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid deficiency. The localisation of MC2R together with ...
PubMed
PubMed Central
The melanocortin-2-receptor (MC(2) receptor), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC(2) receptor in adrenal physiology is exemplified by the condition familial glucocorticoid deficiency, a potentially fatal disease characterised by isolated cortisol deficiency. MC(2)receptor mutations cause ~25% of cases. The ...
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs), which constitute the largest family of membrane proteins, mediate responses to diverse physiological stimuli. The presence of melanocortin 2 receptors (MC2Rs) on the plasma membrane requires the presence of either MC2R ...
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R�MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic�pituitary�adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis. Mutations in MC4R are the single most common cause of monogenic obesity. Investigating the way in which ...
Analysis of the functional expression of the melanocortin 2 receptor (MC2R) from a rather broad spectrum of vertebrates indicates that MC2R is exclusively selective for the ligand, ACTH, and the melanocortin receptor accessory protein 1 (MRAP1) is required for high affinity ACTH binding and activation of MC2R. A phylogenetic analysis ...
The melanocortin 2 (MC(2)) receptor differs from other melanocortin family members in its pharmacological profile and reliance on an accessory protein, MC(2) receptor accessory protein (MRAP), for surface expression and signal transduction. To identify features of the MC(2) receptor responsible ...
The melanocortin 2 receptor (MC2R) accessory protein (MRAP) is a small single-transmembrane domain protein that plays a pivotal role in the function of the MC2R. The pituitary hormone, ACTH, acts via this receptor complex to stimulate adrenal steroidogenesis. Using both coimmunoprecipitation and bioluminescence ...
There are conflicting theories about the evolution of melanocortin MC receptors while only few studies have addressed the evolution of agouti-related peptide (AgRP) and agouti signalling peptide (ASIP), which are antagonists at the melanocortin receptors (MCRs), or the melanocortin MC(2) receptor accessory proteins (MRAP1 and ...
ACTH is the most important stimulus of the adrenal cortex. The precise molecular mechanisms underlying the ACTH response are not yet clarified. The functional ACTH receptor includes melanocortin-2 receptor (MC2R) and MC2R accessory proteins (MRAP). In human embryonic kidney 293/Flp recombinase target cells expressing MC2R, ...
Background: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by isolated glucocorticoid deficiency. Mutations in the ACTH receptor/melanocortin 2 receptor (MC2R), the melanocortin 2 receptor accessory protein (MRAP) or the steroidogenic acute regulatory protein (STAR) ...
Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease resulting from resistance to the action of adrenocorticotropic hormone (ACTH) on the adrenal cortex, which leads to isolated glucocorticoid deficiency with normal mineralocorticoid secretion. It may present in infancy or early childhood with hyperpigmentation, failure to thrive, recurrent infections, hypoglycemic ...
... of Unused MRAPs in Afghanistan.....4 Are the M-ATV, Ultra-Lite MRAP, and JLTV Redundant Programs? ...
DTIC Science & Technology
... in Iraq with Mine-Resistant, Ambush-Protected (MRAP) vehicles by FY2009. ... logistical and readiness concerns, and MRAP rollover accidents could ...
Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC(1)-MC(5)) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC(5) receptor, while pufferfish have 4 ...
The present invention provides a number of accessory gland proteins from Drosophila. The invention also provides an accessory gland protein which is toxic to insect cells and can be used to kill or inhibit the development of insects. Methods of controllin...
National Technical Information Service (NTIS)
Disclosed are compositions of bone accessory cells and methods for their preparation and use. Bone accessory cells are cells which are not hematopoietic and which can reconstitute the expression of bone proteins by human bone cells and support ex vivo exp...
... Michelin.50 With a December 2007 goal of producing 1300 MRAPs per ... tire molds to facilitate an increase in production of MRAP tires. ...
... 4. TITLE AND SUBTITLE The MRAP: A Bad Rap for the Marine Corps 5a. ... Corps' senior leadership. Lieutenant General John Castellaw, ...
... Because of its high costs, the MRAP has already pulled money away from other large DoD acquisitions, most noteworthy, the JLTV program, which ...
... to the 14 to 24 tons of the current MRAP variants) and have better off-road mobility.8 In early December 2008, a Request for Proposal (RFP) was ...
... Orders 813 Mine-Resistant Vehicles from General ... not being included in the 1,600-vehicle order for ... MRAP version to address rollover accidents and ...
... 29 Some maintain that the DOD's plans to acquire large numbers of MRAPs will essentially �kill the Joint Light Tactical Vehicle (JLTV) and HMMWV ...
... Accession Number : ADA543586. Title : Mine-Resistant, Ambush-Protected (MRAP) Vehicles: Background and Issues for Congress. ...
... Congress approved an additional $1.2 billion for MRAP procurement, included in the FY2010 Supplemental Appropriations Act (PL 111-212). ...
Page 1. occasional paper 6 MRAPs, Irregular Warfare, and Pentagon Reform by Christopher J. Lamb, Matthew J. Schmidt, and Berit G. Fitzsimmons ...
... 'Herculean Work' Drives MRAP Production ... these vehicles or into a subsequent vehicle,� Brogan said ... Department is forging ahead to field the current ...
DefenseLINK Web Site
... Vehicles Statement of Michael J. Sullivan, Director Acquisition and Sourcing Management ... Rapid Acquisition of MRAP Vehicles 5a. ...
... from federally funded research, testing and training programs; updated ... Title : Acquisition of Mine-Resistant, Ambush-Protected (MRAP) Vehicles: A ...
This project focuses on the DNA polymerase and accessory proteins of phage T7 for use in DNA sequence analysis. T7 DNA polymerase (gene 5 protein) interacts with accessory proteins for the acquisition of properties such as processivity that are necessary ...
The mechanism for genetic errors and genomic instability in breast cancer cells have not been fully delineated. Defects in DNA polymerase delta and its accessory proteins could contribute to the molecular etiology of breast cancer. DNA polymerase delta an...
... In addition to ER, a number of accessory proteins are apparently ... is complexed with Hsp9O and other molecular chaperone components, including ...
The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory ...
The goal of this investigation is to test the hypothesis that estrogen agonists and antagonists promote differential transcriptional activity of the estrogen receptor (ER) by altering accessory protein interactions. We have shown that one or more ER-assoc...
... and Palumbi 1996; Biermann 1998), and mammalian egg coat proteins (Swanson et al. 2001a). In Drosophila, a group ... ...
NBII National Biological Information Infrastructure
The male accessory glands in Triatoma are tubular and produce substances with some functions related to production of the spermatophore. In the current study, the cytochemistry of male accessory glands was evaluated in starved Triatoma brasiliensis and adult Triatoma melanica. The storage of carbohydrates and proteins in T. melanica ...
Mine resistant ambush protected (MRAP) vehicles offer an excellent case study for investigating the current debate over the Pentagon's emphasis on developing and fielding irregular warfare capabilities. The debate was highlighted by a series of recent art...
. Similar innervation and musculature can be seen in the male accessory glands of honeybee drones (Landim, 2007, 2008). Whereas target sites of male accessory gland fluids have been mapped in female Drosophila and protein patterns of honey bee drone accessory glands. Genetics and Molecular Research 4, 473
E-print Network
SummaryThe export of proteins from their site of synthesis in the cytoplasm across the inner membrane is an important aspect of bacterial physiology. Because the location of extracytoplasmic proteins is ideal for host-pathogen interactions, protein export is also important to bacterial virulence. In bacteria there are conserved ...
... Prototype & Demonstrators Enabling Integration & Technology Development FTTS JLTV Future Force MRAP Thermal / CFD Crew Safety ...
... of irregular warfare equipment, such capabilities typically are abandoned shortly after ... for reconnaissance and close fire support as well as brown ...
... Does this strategy provide a model for streamlining the acquisition process, or was it ... But how is this to be done, given that attempts to streamline the ...
