Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too. (Atomindex citatio...

... the result of radiation accidents or nuclear/radiological terrorism (1). The current lack of radioprotectors and therapeutic agents that are safe, effective and approved for use in victims of accidental or...

A case of a patient in whom carcinoma of the right temporal bone developed 39 years after a series of injections of radium chloride is presented. Carcinomas of the temporal bone and paranasal sinuses are a complication of radium administered therapeutically or ingested accidentally by watch dial painters.

Chromosome aberration frequency provides the most reliable biological marker of dose for detecting acute accidental radiation exposure. Significant radiation-induced changes in the frequency of chromosome aberrations can be detected at very low doses. Our...

In risk studies for plants of the nuclear industry usually the number of fatalities by radiation induced health effects are assessed. They are divided into 'early fatalities' (mortality by acute radiation syndrome) and 'late fatalities' (deaths due to leu...

Effect of Deep Space Radiation on Human Hematopoietic Stem Cells. 2001. 2002. Radiation Effects. Human. Factors Modulating Radiation-Induced G-2 Delays ...

... is heightened due to the risk of radiological terrorism or radiation accidents (1, 3, 6, 8). Protection ... M. Drouet. Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. ...

Hematopoietic depression and subsequent susceptibility to potentially lethal opportunistic infections are well-documented phenomena following radiotherapy. Methods to therapeutically mitigate radiation-induced myelosuppression could offer great clinical value. In vivo studies have demonstrated that interleukin-6 (IL-6) stimulates pluripotent ...

Recombinant human interleukin-1(alpha) (rhIL-1(alpha)) has significant potential as a radioprotector andlor treatment for radiation- induced hematopoietic injury. Both IL-1 and whole-body ionizing irradiation acutely stimulate the hypothalamic-pituitary-a...

This study compared the therapeutic potential of recombinant, native versus pegylated megakaryocyte growth and development factor 'rMGDF and PEG- rMGDF, respectively', as well as that of the combined administration of PEG- rMGDF and r-methionyl human gran...

Our previous study demonstrated that human umbilical cord blood-derived stromal cells (hUCBDSCs) support the growth of hematopoietic stem cells, and promote the expansion of colony-forming units of megakaryocyte (CFU-Mk) even more efficiently than human bone marrow stromal cells (hBMSCs). Given the unique role of hUCBDSCs in megakaryocytopoiesis in vitro, in this follow up ...

Compounds that can protect cells from the effects of radiation are important for clinical use, in the event of an accidental or terrorist-generated radiation event, and for astronauts traveling in space. One of the major concerns regarding the use of radio-protective agents is that they may protect cells initially, but predispose surviving cells to increased genomic ...

Compounds that can protect cells from the effects of radiation are important for clinical use, in the event of an accidental or terrorist-generated radiation event, and for astronauts traveling in space. One of the major concerns regarding the use of radio-protective agents is that they may protect cells initially, but predispose surviving cells to increased genomic ...

?-Asarone (1-propenyl-2,4,5-methoxybenzol), one of the active components of Acorus calamus extract, was examined for its efficacy as a radioprotector in mice exposed to lethal and sublethal whole-body ?-radiation. Oral administration of ?-asarone 1h prior to the radiation exposure reduced radiation induced alterations in the endogenous antioxidant defense ...

. Experiments were undertaken in an effort to determine the degree of similarity between natural and radiation induced aging, and to determine the causes for the latter. Several severe non-specific stresses were applied to mice either as single massive doses or as smaller doses administered over a large fraction of the life span of the animals. ...

Radiation-induced hair graying is caused by irreversible defects in the self-renewal and/or development of follicular melanocyte stem cells in the hair follicles. Kit signaling is an essential growth and differentiation signaling pathway for various cell lineages including melanocytes, and its radioprotective effects have been shown in hematopoietic cells. ...