Long-term potentiation in hippocampal neurons has stages that correspond to the stages of learning and memory. Early-phase (10�30 min) potentiation is accompanied by rapid increases in clusters or puncta of presynaptic and postsynaptic proteins, which depend on actin polymerization but not on protein synthesis. We have now examined changes in pre- and postsynaptic puncta and ...

Imaging studies have shown that even the earliest phases of long-term plasticity are accompanied by the rapid recruitment of synaptic components, which generally requires actin polymerization and may be one of the first steps in a program that can lead to the formation of new stable synapses during late-phase ...

High temperature tests of dimensional changes accompanying plastic deformation of pyrolytic graphite

... FILAMENT WOUND REINFORCED PLASTICS FOR AIRCRAFT ... For tubular elements, the calculated ... composite structural element is accompanied ...

RNA transcription, protein translation and signaling through the mammalian Target of Rapamycin (m on mammalian Target of Rapamycin (mTOR), a kinase complex that phosphorylates and activates key positive the tetanus [24]. Late-Phase LTP elicited by either HFS or TBS is eliminated by the mTOR inhibitor rapamycin

This document contains detailed information to accompany the Health Physics Society�s position paper, "Guidance for Protective Actions Following a Radiological Terrorist Event". It describes radiological events and delineates the responsibilities of federal, state, and local government agencies in establishing and implementing protective action guidelines (PAG) for the ...

Aging is associated with cognitive impairment in numerous animal species. Across taxa, decline in learning performance is linked to chronological age. The honey bee (Apis mellifera), in contrast, offers an opportunity to study such aspects of aging largely independent of age per se. This is because foraging onset can be decoupled from chronological age, although workers typically first perform ...

Deletions, translocations, or point mutations in the CREB-binding protein (CBP) gene have been associated with Rubinstein-Taybi Syndrome; a human developmental disorder characterized by retarded growth and reduced mental function. To examine the role of CBP in memory, transgenic mice were generated in which the CaMKII[alpha] promoter drives expression of an inhibitory truncated CBP protein in ...

Paeonol was tested for its anti-inflammatory and analgesic effects in a rat model of carrageenan-evoked thermal hyperalgesia. The possible mechanisms involved in these effects were also investigated.Pre- and post-treatment with paeonol (30, 50 or 100 mg kg^?1, i.p.) dose-dependently inhibited the carrageenan-evoked thermal hyperalgesia.Treatment with paeonol dose-dependently ...

In the late phase of a severe reactor accident, the molten corium interacts with the vessel wall, and it can lead to the failure of the lower head. Through the failed bottom wall, part of the corium can flow into the cavity, and air can enter the primary circuit. The residual fuel in the core periphery will be further oxidized in air atmosphere. The ...

Several hot flow anomaly (HFA) like events were observed by STEREO magnetometer (MAG) and solar wind thermal proton (PLASTIC) and electron (SWEA) instruments during the Earth orbit phase of STEREO B in February-March, 2007. The magnetic signature of the tangential discontinuities (TDs) was observed but the resolution of PLASTIC is not sufficient to ...

The purpose was to study homosynaptic long-term depression (LTD) at the parallel fiber-Purkinje cell synapse in the mdx mouse, a murine model of the human dystrophinopathy, Duchenne muscular dystrophy (DMD), in order to examine whether the absence of dystrophin affects the induction and extent of this form of synaptic plasticity. Sharp intracellular electrodes were used to ...

Sep 7, 2011 ... Fifteen percent of the flares have a distinct "late phase flare" some minutes to hours later that has never before been observed. This late phase ...

3 days ago ... SDO Spots a Late Phase in Solar Flares. Fifteen percent of the flares have a distinct "late phase flare" some minutes to hours later that has ...

Background: The detrimental effects of metoprolol on early-phase preconditioning (pc) have been proven. The late phase of pc is mediated via gene transcription and cyclooxygenase-2 (COX-2) was identified as one of the key mediators. The effect of metoprolol on this is yet unknown as is its effect on cellular energy metabolism and reactive oxygen species ...

Small fatigue crack growth has been studied in two 7000 series aluminum alloys possessing different grain sizes. As it has been suggested that the relatively large plastic deformation associated with small fatigue cracks may explain their fast growth rates compared to long cracks, the work focused on experimental measurement of the plastic zone size (PZS) ...

A general theory of an elastic-plastic continuum, valid for non-isothermal deformations and accompanied by explicit thermodynamical restrictions, was developed recently by Green and Naghdi. A special case of this theory, assuming isothermal conditions, le...

BackgroundLong-term potentiation (LTP) at the parallel fibre�Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic plasticity. The induction mechanism for LTP at this synapse is considered reciprocal to �classical� LTP at hippocampal CA1 pyramidal neurons: kinases promote increased trafficking of AMPA receptors into the ...

Three independent methods for measuring plane stress fracture resistance in the large-scale plastic yielding regime were tested and were found to give equivalent results. The three methods were the J-integral technique, a method based on the increase in compliance that accompanies the development of a plastic zone, and a method based ...

Plasticity encompasses the ability of the nervous system to adapt to injury and the ability of the developing and mature brain to change in response to experience. This week's Special Issue of Science focuses on systems-level approaches to understanding cortical plasticity, especially during development. The accompanying Focus Issue of ...

The febrile increase of body temperature is regarded as a component of the complex host response to infection or inflammation that accompanies the activation of the immune system. Late phases of fever appear mediated by pro-inflammatory cytokines called endogenous pyrogens. The rise of body temperature is beneficial because it ...

Although much is known about long-term memory (LTM) consolidation, what puts the "long" in LTM is the exclusive feature of persisting over time. However, until recently the molecular mechanisms underneath memory persistence had never been properly studied. In rats, the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12�h after ...

Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts ...

We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on hippocampus, immunohistochemical studies in aged THY-Tau22 ...

The purpose of this note is to show that localized plastic flow accompanies intergranular fracture within the strongly ordered L1/sub 2/ aluminide Ni/sub 3/A1. The work is part of a larger study on the brittle-to-ductile transition of this material, and was carried out to answer the question: Is the plastic strain which ...

Long-term synaptic plasticity exhibits distinct phases. The synaptic tagging hypothesis suggests an early phase in which synapses are prepared, or "tagged," for protein capture, and a late phase in which those proteins are integrated into the synapses to achieve memory consolidation. The synapse specificity of the tags is consistent ...

-in. high, for others to select and place categories into tared 55-gal open-top drums or plastic bags into a plastic bag or metal container with minimum opening. Loose dirt on the boxboard coupons must accompany If the weight of the entire component lot were 225 Ib, for example, and stored in 10 plastic bags, the ...

Antisecretory factor (AF) is expressed in all tissues of mammals, inhibits intestinal hypersecretion and has anti-inflammatory properties as well. Endogenous AF synthesis may be stimulated by feeding hydrothermally processed cereals. Alternatively, freeze-dried egg yolk can be used as a source of exogenous AF. Several reports have suggested that AF from freeze-dried egg yolk may be useful in ...

Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids, and their subsequent metabolism by cyclooxygenases (COXs) and lipoxygenases (LOXs) may produce potent eicosanoid mediators modulating different stages of the ...

We have studied the influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. In a double-blind, placebo-controlled trial of immunotherapy in 40 adult hay fever sufferers, clinical improvement was accompanied by a decrease in the size of the late-phase skin ...

Characteristics of protective mechanisms during pregnancy were investigated using neonatally thymectomized (NTx) and/or pregnant mice infected with sublethal doses of Listeria monocytogenes, of which the explosive growth at an early phase of 2 or 3 days after infection is prevented by non-immune macrophages, and complete elimination at a late phase from 4 ...

The new solar extreme ultraviolet (EUV) irradiance observations from NASA Solar Dynamics Observatory

Phase transitions occurring after photon decoupling are shown to result in significant density perturbations.