BACKGROUND & AIMS: Protease-activated receptors (PARs) are expressed in the enteric nervous system. Excessive release of proteases has been reported in functional and inflammatory bowel diseases. Studies in several animal models indicate the involvement of neural PARs. We studied the actions of different PAR-activating peptides ...

It has been proposed that c-Myc proapoptotic activity accounts for most of its restraint of tumor formation. We established a telomerase-immortalized human epithelial cell line expressing an activatable c-Myc protein. We found that c-Myc activation induces, in addition to increased sensitivity to apoptosis, reductions in cell motility and invasiveness. Transcriptome analysis revealed that ...

Background: To investigate the causes of paravalvular aortic regurgitation (PAR) after the implantation of the Medtronic CoreValve prosthesis (MCRS). Methods and Results: Fifty-six patients underwent MSCT before TAVI with a MCRS and PAR was assessed with transthoracic echocardiography (TTE) between 5 and 10 days after TAVI. The aortic annulus smallest and ...

OBJECTIVE: To investigate whether protease activated receptor (PAR)1 and/or PAR2 promotes the invasiveness/proliferation of synovial fibroblasts (SF) and to determine the signalling mechanisms. METHODS: SF were isolated from synovial tissues from patients with rheumatoid arthritis (RA), osteoarthritis (OA) and from PAR1 or ...

BackgroundSerum concentrations of soluble urokinase-type plasminogen activator receptor (suPAR) have a strong independent association with HIV-1-related mortality. The practical utility of plasma suPAR in assessing short-term all-cause mortality risk was evaluated in patients with advanced immunodeficiency enrolling in an antiretroviral treatment (ART) ...

BackgroundThe objective of this study was to examine Streptococcus pneumoniae isolates collected from a longitudinal surveillance program in order to determine their susceptibility to currently used fluoroquinolones and of the frequency and type of mutations in the quinolone-resistant determining regions (QRDRs) of their parC and gyrA genes.MethodsThe Canadian Bacterial ...

Taking the issue of tumor categorization a step forward and establish molecular imprints to accompany histopathological assessment is a challenging task. This is important since often patients with similar clinical and pathological tumors may respond differently to a given treatment. Protease-activated receptor-(1) (PAR(1)), a G protein-coupled receptor (GPCR), is the first ...

will be evaluated for scientific and technical merit by an appropriate peer review group convened by CSR and in accordance with NIH peer review procedures (http://...

A program for designing grooves for transmissions according to French standards was written for the HP 41C calculator.

... 23.4.1. Prepare postal activity reporting system (PARS) reports, postal net alerts (PNA), and other mail movement data analyses according to DoD ...

OBJECTIVE: Emerging evidence suggests that protease-activated receptors-1 and -2 (PAR1 and PAR2) can signal together in response to proteases found in the rapidly changing microenvironment of damaged blood vessels. However, it is unknown whether PAR1 and PAR2 promote or mitigate the hyperplastic response to ...

BackgroundThe ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and ...

Background:Microenvironmental conditions in normal or tumour tissues and cell lines may interfere on further biological analysis. To evaluate transcript variations carefully, it is common to use stable housekeeping genes (HKG) to normalise quantitative microarrays or real-time polymerase chain reaction results. However, recent studies argue that HKG fluctuate according to ...

Thrombin promotes vascular smooth muscle cell (SMC) proliferation and inflammation via protease-activated receptor (PAR)-1. A further thrombin receptor, PAR-3, acts as a PAR-1 cofactor in some cell-types. Unlike PAR-1, PAR-3 is dynamically regulated at the mRNA level in thrombin-stimulated SMC. ...

To cite this article: Banfi C, Brioschi M, Lento S, Pirillo A, Galli S, Cosentino S, Tremoli E, Mussoni L. Statins prevent tissue factor induction by protease-activated receptors�1 and 2 in human umbilical vein endothelial cells in�vitro. J Thromb Haemost 2011; 9: 1608-19. Summary.? Background:? Protease-activated receptors (PARs) are G-protein-coupled receptors that ...

What regulates chromosome segregation dynamics in bacteria is largely unknown. Here, we show in Caulobacter crescentus that the polarity factor TipN regulates the directional motion and overall translocation speed of the parS/ParB partition complex by interacting with ParA at the new pole. In the absence of TipN, ParA structures can ...

BackgroundThe parvulin-type peptidyl prolyl cis/trans isomerase Par14 is highly conserved in all metazoans. The recently identified parvulin Par17 contains an additional N-terminal domain whose occurrence and function was the focus of the present study.ResultsBased on the observation that the human genome encodes Par17, but bovine and ...

BackgroundProtease-Activated Receptors (PARs), members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs), but the signaling pathways downstream of PAR activation in HOKs have not ...

Background and Purpose.? Many cells express Proteinase Activated Receptor 2 (PAR(2) ) on their plasma membrane. PAR(2) is a sensor for proteolytic enzymes (e.g. trypsin, tryptase) which prune the receptor N-terminus, enabling it to signal via its transmembrane domain to intracellular G proteins that activate signaling networks. Studies on ...

12 /department of mathematics and computer science 1/181/18 PARS: A Process Algebra with Resources to Processes 5. Conclusion and Future Works #12;12 /department of mathematics and computer science 3/183/18 1 of mathematics and computer science 5/185/18 1. Motivation Benefits of using PARS: 1. independent and process

We observed that human rhabdomyosarcoma (RMS) cells highly express a tissue factor (TF) that promotes thrombin formation, which indirectly and directly affects RMS progression. First, we found that thrombin activates platelets to generate microvesicles (PMVs), which transfer to RMS cells� ?2?3 integrin and increase their adhesiveness to endothelial cells. Accordingly, RMS ...

Ambroise Par� (1510-1590) was actively involved in wound treatment, studying wounds from various points of view. Many of his published works provide cutting-edge insights regarding nutrition, pain, and debridement, as well as psychological counsel for wounded persons--advanced thoughts, considering the times. Par� believed the energy of the human body ...

BackgroundProtease activated receptors (PARs) consist of a family of four G protein-coupled receptors. Many types of cells express several PARs, whose physiological significance is mostly unknown.ResultsHere, we show that non-invasive resonant waveguide grating (RWG) biosensor differentiates signaling of endogenous protease activated receptor subtype 1 ...

BackgroundOsteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteinase-activated receptor (PAR)-2. Previous studies demonstrated that PAR-2 messenger (m)RNA and protein levels increased in OA synovial cells, ...

OBJECTIVES: To estimate excess mortality in patients with an alcohol use disorder and to calculate the population-based impact attributable to this disorder, with emphasis on differences according to gender and age. METHODS: We carried out a longitudinal study of a dynamic retrospective cohort in which 7,109 patients (76.5% men) aged 18-64 years who started medical day ...

OBJECTIVES: To establish baseline concentrations of plasminogen activators and their inhibitors in normal knee synovial fluids, and to compare them with well characterised osteoarthritis (OA) and rheumatoid arthritis (RA) knee fluids. METHODS: A total of 26 normal subjects, 71 patients with OA, and 17 patients with RA underwent knee aspiration. Patients with OA were subclassified ...

BackgroundMany coral reef organisms are photosynthetic or have evolved in tight symbiosis with photosynthetic symbionts. As such, the tissues of reef organisms are often exposed to intense solar radiation in clear tropical waters and have adapted to trap and harness photosynthetically active radiation (PAR). High levels of ultraviolet radiation (UVR) associated with sunlight, ...

Objective:In this prospective study we investigated the role of plasma levels of soluble urokinase plasminogen activator receptor (suPAR) in children with urinary tract infection.Material and methods:We measured the levels of plasma suPAR during admission in 42 children with suspected acute pyelonephritis and compared the results to acute DMSA ...

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation of hPAR2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. In ...

Taking the issue of tumor categorization a step forward and establish molecular imprints to accompany histopathological assessment is a challenging task. This is important since often patients with similar clinical and pathological tumors may respond differently to a given treatment. Protease-activated receptor-₁ (PAR₁), a G ...

Background and AimsKaolin applied as a suspension to plant canopies forms a film on leaves that increases reflection and reduces absorption of light. Photosynthesis of individual leaves is decreased while the photosynthesis of the whole canopy remains unaffected or even increases. This may result from a better distribution of light within the canopy following kaolin application, but this ...

subdeterminants of the atomic stress tensor according to the definition of Bom and Huang [18]. A criterion�faut est cr�� en supprimant un atome et en suivant la r�ponse du systkme. Nous observons trois comportements typiques : la persistance sur place du � trou � laiss� par l'atome supprimd, sa migration par des

Application Receipt Dates: February 1, June 1, October 1 Contact: see announcement for contacts according to Institute

The new edition of the book Fish Diseases has accordingly developed in sequel to the third edition (published in 1954) and to the contribution by Schaperclaus in Virus Infections in Fishes which appeared in the year 1969. In the beginning, the general par...

The new edition of the book Fish Diseases has accordingly developed in sequel to the third edition (published in 1954) and to the contribution by Schaperclaus in Virus Infections in Fishes which appeared in the year 1969. In the beginning, the general par...

The application of QCD to exclusive two-photon reactions is based on the work of Brodsky and Lapage. According to their formalism the process is factorized into a non-perturbative part, the hadronic wave function of the final state, and a perturbative par...

One survival suit of Model HH E-307 has been tested with regards to leakage, oil resistance, buoyancy, temperature cycling and strength according to IMO Resolution A 521 (13). The results for the suit are within the acceptance limits for the mentioned par...

Three fast Pulsed kicker/bumper magnets are required in the positron accumulator ring (PAR) for the purpose of beam injection and/or extraction at 450 MeV. According to the Conceptual Design Report (CDR), these three magnets have, identical specifications...

Swaziland is governed as a modified traditional monarchy with executive, legislative, and limited judicial powers ultimately vested in the King (Mswati III). The King rules according to unwritten law and custom, in conjunction with a partially elected par...

1'efficacite est bien demontree, necessitent un apport semi-empirique en ... turbulence algebrique classique, un effort important ayant ete accorde a ... maillage par rapport aux methodes de Navier-Stokes, ou a 1'approximation ...

BACKGROUND: Irritable bowel syndrome (IBS) pathophysiology has not been fully understood. Abnormalities of serine proteases have been identified in IBS patients. In addition, protease-activated receptors (PAR) activation interferes with several components of the pathogenesis of IBS, so, evaluating the PAR expression in IBS patients may contribute to ...

The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections are scarce. To elucidate the role of ...

BACKGROUND & AIMS: Protective immunization limits Helicobacter infection of mice by undetermined mechanisms. Protease-activated receptor 2 (PAR2) signaling is believed to regulate immune and inflammatory responses. We investigated the role of PAR2 in vaccine-induced immunity against Helicobacter infection. METHODS: Immune responses against Helicobacter ...

BACKGROUND AND OBJECTIVE:To describe the effect of a "radiation-first" combination treatment strategy for neovascular age-related macular degeneration (AMD) with ranibizumab rescue therapy. PATIENTS AND METHODS:Non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 16 Gy was given in a single session through three locations in the inferior pars plana in ...

Jul 28, 2005 ... Conclusion. According to the scientific literature, GX 301-2 consists of a neutron star and a massive supergiant B star which is at least 35 times ...

... (b) If all facts are stipulated, the proceedings shall go to conclusion in accordance with part 17 of this title and the...Government for the record. Thereafter, the proceedings shall go to conclusion in accordance with part 17 of this title and...

OBJECTIVE: The purpose of this pictorial essay is to review the anatomic variations and congenital anomalies of the neural arch and its processes as seen on MDCT images of the spine. CONCLUSION: Variations and anomalies of the pedicles, pars interarticularis, laminae, and spinous processes may be readily identified on MDCT studies. Familiarity with their ...

In this paper we consider a general problem of astrophysical lasers operating with optical pumping by accidental resonance (PAR) with strong spontaneous emission lines of other elements. The origin of population inversion and the coefficient of amplification due to the optical excitation of atoms (ions) by a four-level scheme with PAR are analyzed. We ...

... The important conclusion to be drawn 'is that the sensory system according ... walking. ... men on night watches during the war were trained to search for ...

Table of Contents: Foreword; Introduction and Summary; Background; Human Rights; National Minorities; Conclusions and Outlook; Endnotes.

Table of Contents: Foreword; Introduction and Summary; Background; Current Human Dimension Concerns; Conclusions and Outlook; and Endnotes.

According to the NASA Advisory Council's Task Force on Goals, Recognized leadership absolutely requires the expansion of human life beyond the Earth, ...

Encyclopedia article on bumble bees. If interest to engineers because of the work of John McMasters in trying track down the myth that scientists say "bumble bees can't fly. Excerpt: "According to 20th century folklore, the laws of aerodynamics prove that the bumblebee should be incapable of flight, as it does not have the capacity (in terms of wing size or beats per second) ...

Elevated sphingolipids have been associated with increased cardiovascular disease. Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT). The SPT enzyme is composed of the SPTLC1 and -2 subunits, and here we describe a novel protein-protein interaction between SPTLC1 and the PDZ protein Par3 ...

Elevated sphingolipids have been associated with increased cardiovascular disease. Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT). The SPT enzyme is composed of the SPTLC1 and -2 subunits, and here we describe a novel protein-protein interaction between SPTLC1 and the PDZ protein Par3 ...

BackgroundWhile protease-activated-receptor 1 (PAR₁) plays a central role in tumor progression, little is known about the cell signaling involved.Methodology/Principal FindingsWe show here the impact of PAR₁ cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis ...

The synergistic inhibition between 4-(2-pyridylazo) resorcin (PAR) and chloride ion on the corrosion of cold rolled steel in 1.0 M phosphoric acid was studied using weight loss and potentiodynamic polarization method. Results obtained revealed that single PAR is not an effective inhibitor for steel corrosion in phosphoric acid, but in the presence of ...

ObjectiveTo evaluate whether the results of cerebrospinal fluid (CSF) flow quantification differ according to the anatomical location of the cerebral aqueduct that is used and the background baseline region that is selected.Materials and MethodsThe CSF hydrodynamics of eleven healthy volunteers (mean age = 29.6 years) were investigated on a 1.5T MRI system. Velocity maps were ...

The neuroendocrine hypothalamic-pituitary axis undergoes morphological and biochemical changes throughout gestation. In viscacha, pregnancy lasts approximately 154 days, and three stages can be described: early, mid- and late pregnancy. The aim of this work was to study the pituitary LH-gonadotrophs, FSH-gonadotrophs, somatotrophs, corticotrophs and thyrotrophs of non-pregnant and pregnant adult ...

ObjectiveThis investigation was conducted to evaluate a new, safe entry point for the C2 pedicle screw, determined using the anatomical landmarks of the C2 lateral mass, the lamina, and the isthmus of the pars interarticularis.MethodsFifteen patients underwent bilateral C1 lateral mass-C2 pedicle screw fixation, combined with posterior wiring. The C2 pedicle screw was inserted ...

To study the molecular mechanisms of circadian gene expression, we have sought to identify genes whose expression in mouse liver is regulated by the transcription factor DBP (albumin D-site-binding protein). This PAR basic leucine zipper protein accumulates according to a robust circadian rhythm in nuclei of hepatocytes and other cell types. Here, we ...

Purpose:The evaluation of anatomic and visual outcomes in macular hole cases treated with internal limiting membrane (ILM) peeling, brilliant blue (BB), and 23-gauge pars plana vitrectomy (PPV).Materials and methods:Fifty eyes of 48 patients who presented between July 2007 and December 2009 with the diagnosis of stage 2, 3, or 4 macular holes according to ...

To study the molecular mechanisms of circadian gene expression, we have sought to identify genes whose expression in mouse liver is regulated by the transcription factor DBP (albumin D-site-binding protein). This PAR basic leucine zipper protein accumulates according to a robust circadian rhythm in nuclei of hepatocytes and other cell types. Here, we ...

The main conclusions of many investigations about general requirements of plants for spectral composition of PAR (photosynthetically active radiation) are based on phylogenetic aspects of plant growth. We think that these aspects are not the main criteria...

This essay explains how economic analysis and enforcement experience support the conclusion that cartel activity should be viewed as a serious crime and punished with serious sanctions on both business enterprises and individuals. My subtitle provides par...

In conclusion, Figure 3 shows a typical Class I1 Post-Saturn. It is a ... Figure 4 shows a typical Class 111 Post-Saturn concept. The data shown ...

with infor- mation provided by scientific groups, and it still formally seeks scientific guidance -- par -- but it is also because scientific infor- mation does not usually point ineluctably to a single conclusion to know what researchers think the health impacts of dirtier air would be. Often

PurposeTo understand the functional and preclinical efficacy of targeting urokinase plasminogen activator receptor (u-PAR) in ovarian cancer.Experimental DesignExpression of u-PAR was studied in 162 epithelial ovarian cancers, including 77 pairs of corresponding primary and metastatic tumors. The effect of an antibody against u-PAR ...

Purpose:To evaluate the efficacy and safety of the pars plana clip (PPC) in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods:Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the ...

ABSTRACT: OBJECTIVE: To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells. Methods: The nude mice were treated with PBS, ulinastatin, docetaxel, and ulinastatin plus docetaxel, respectively. Their effects on 1) cell invasion ability was assayed using Transwell; ...

ObjectiveTo investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells.MethodsThe nude mice were treated with PBS, ulinastatin, docetaxel, and ulinastatin plus docetaxel, respectively. Their effects on 1) cell invasion ability was assayed using Transwell; 2) expression of ...

The Par Pond unit designated under CERCLA consists of sediments within a Savannah River Site (SRS) cooling water reservoir. The sediments are contaminated with radionuclides and nonradioactive constituents from nuclear production reactor operations. The mercury in Par Pond is believed to have originated from the Savannah River. Because of ...

BackgroundThe urokinase receptor (uPAR) governs several functions necessary during invasion and metastasis such as motility, degradation of the extracellular matrix and adhesion. This receptor has been recently associated with clinical prostate cancer progression. Experimentally, inhibition of uPAR reduces colonization of extra-prostatic sites in animal ...

OBJECTIVE: Pancreatic islet beta cell death occurs in both type 1 (rapid onset) and type 2 (delayed onset) diabetes mellitus; the inflammatory mediators seem to play an important role in the beta cell failure/apoptosis in both cases. PAR-2 expression has been associated with inflammation. Therefore the objective of our study was to identify the new anti-diabetic drug target ...

BackgroundThe urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most ...

BACKGROUND: Atopic diseases are the most common chronic diseases of childhood, and the genetics of atopy are complex and heterogeneous. Protease-activated receptor-2 (PAR-2) is involved in various inflammatory diseases, but the association of PAR-2 with allergic diseases remains unclear. OBJECTIVE: To examine the contribution of genetic variation of ...

Background and purpose: We hypothesised that PAR(2) -mediated vasorelaxation in murine aorta tissue can be due in part to the release of adipose tissue-derived relaxing factors (ADRFs). Experimental approach: Aorta rings from obese TallyHo and C57Bl6 intact or PAR(2) -null mice either without or with perivascular adipose tissue (PVAT) were contracted with ...

BackgroundOver the past decade, practitioners in primary health care (PHC) settings in many countries have issued written prescriptions to patients to promote increased physical activity or exercise. The aim of this study is to describe and analyse a comprehensive physical activity referral (PAR) scheme implemented in a routine PHC setting in �sterg�tland County. The study ...

ObjectiveOur aim was to determine the contribution of proteinase-activated receptor-2 (PAR₂)-expressing bone marrow-derived cells on the development of colonic inflammation.MaterialsChimeric mice were generated by injecting bone marrow cells from wildtype (PAR2+/+) or ...

The VerifyNow� P2Y12 (VN-P2Y12) test reports thienopyridine-mediated platelet inhibition relative to a "BASE" channel, potentially eliminating the need for predrug patient assessment, by activating platelets through a P2Y(12)-independent pathway. The original formulation of the BASE channel used a protease activated receptor-1 (PAR-1) peptide as agonist. However, more potent ...

Direct repair of spondylolisthesis can save a functional segment in young patients with slight slipping. Since 1968 many surgeons have proposed different technical solutions to obtain the isthmic repair. Their results changed according to the technique used, the extent of listhesis and the age of the patient. The aim of our study was to perform a retrospective review on the ...

Brain-derived neurotrophic factor (BDNF) is a cytokine that plays important roles in the survival, development, and plasticity of neurons. BDNF is also expressed in peripheral tissues and cells. In this article, we report the BDNF release reaction through thrombin stimulation and its localization in human platelets. Platelets from healthy volunteers were subjected to PAR1-AP ...

Proteinase-activated receptors (PARs) are involved in both inflammation and tumorigenesis in epithelial cells. Interleukin (IL)-8 is a potent chemoattractant and is also involved in angiogenesis. The molecular mechanism whereby PARs induce epithelial IL-8 expression is not known. In HT-29 colonic epithelial cells, PAR(1) or ...

The mechanisms by which immature thymocyte apoptosis is induced during negative selection are poorly defined. Reports demonstrated that cross-linking of T-cell receptor leads to stromal cell activation, expression of inducible nitric oxide synthase (iNOS) and, subsequently, to thymocyte apoptosis. Therefore we examined, whether NO directly or indirectly, through peroxynitrite formation, causes ...

SummaryBackgroundCentrosome orientation toward the leading edge of migrating cells depends on dynein and microtubules (MTs) and as well on a number of signaling factors at the leading edge. However, centrosomes are maintained at the cell center during orientation in fibroblasts suggesting that factors working at sites other than the leading edge may also be involved.ResultsIn a search for factors ...

INTRODUCTION: For children and adolescents who are very active athletes, fresh lumbar spondylolysis is the main pathologic cause of lower back pain (LBP). However, regarding the terminal-stage spondylolysis (pars defect), there have been few studies to clarify the pathomechanism of LBP. The purpose of this study is to clarify the cause of LBP associated with ...

Peroxynitrite, a potent oxidant formed by the reaction of nitric oxide and superoxide causes thymocyte necrosis, in part, via activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS). The cytotoxic PARS pathway initiated by DNA strand breaks and excessive PARS activation has been shown to deplete cellular energy pools, ...

We examined the antimicrobial susceptibilities of 85 Neisseria gonorrhoeae isolates, classified according to the presence of amino acid substitutions in the GyrA and ParC proteins, to 12 fluoroquinolones and 7 other antibiotics. Sitafloxacin and HSR-903 showed excellent activity against N. gonorrhoeae, including strains with both GyrA and ...

R�sum�Objectif:�tudier la fiabilit� en population clinique francophone d�un auto-questionnaire portant sur l�instabilit� �motionnelle des adolescents.M�thode:Apr�s recension des �crits et consultation d�experts, l��chelle de Labilit� �motionnelle (Affective Lability Scale) d�velopp�e par Harvey et collaborateurs (1989) a �t� choisie. Une ...

HISTORIQUE :Au cours des trois derni�res d�cennies, une attention grandissante a �t� port�e � l��tude du syndrome de vulvodynie, soit un inconfort vulvaire chronique inexpliqu�, �prouv� en l�absence de pathologie pr�cis�e. En plus d�avoir des ...

Background and purpose:Proteinase-activated receptor 2 (PAR₂) is a G-protein coupled receptor associated with many pathophysiological functions. To date, the development of PAR₂ antagonists has been limited. Here, we identify a number of novel peptide-mimetic PAR₂ ...

BackgroundIn addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mechanism of action in the invasion, metastasis, and proliferation process in gastric cancer have yet to be completely elucidated. Here, we analyzed the ...

BackgroundProtease-activated receptors (PAR) are present in the urinary bladder, and their expression is altered in response to inflammation. PARs are a unique class of G protein-coupled that carry their own ligands, which remain cryptic until unmasked by proteolytic cleavage. Although the canonical signal transduction pathway downstream of ...

les covariables ont une structure similaire `a celle consid�er�ee par Rice (1986) dans ce contexte�enalis�es par Chen (1987). Vitesses minimax : probl`eme de variables corr�el�ees Rice (1986) dans un contexte�etrique du mod`ele ne soit pas forte. La conclusion de Rice (1986) sur le comportement des estimateurs dans

Students with intellectual disabilities are taking the lead conducting participatory action research (PAR) to chronicle their college experience as part of a national college access initiative. This research currently involves college students with intellectual disabilities documenting their experiences using multimedia tools. These data are then shared via a digital ...

BackgrounduPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts.MethodsTo investigate whether cholesterol could regulate uPAR and MMP-9 in breast carcinoma, we used M?CD (methyl beta cyclodextrin, which extracts cholesterol from lipid rafts) to disrupt lipid rafts and ...

PurposeProtease-activated receptor-2 (PAR₂) is highly expressed throughout the gut and regulates inflammatory, mitogenic, fibroproliferative, and nociceptive responses to injury. PAR₂ is strikingly upregulated and exhibits increased activation in response to intestinal irradiation. We examined the mechanistic ...

BACKGROUND & AIMS: The effects of trypsin on pancreatic ductal epithelial cells (PDEC) vary among species and depend on localization of proteinase-activated receptor-2 (PAR-2). Bicarbonate secretion is similar in human and guinea pig PDEC; we compared its localization in these cell types and isolated guinea pig ducts to study the effects of trypsin and a ...

BackgroundAll four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders.MethodsFor this purpose, we used a protein/DNA combo array containing 345 ...

The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and metastasis. In this study, we achieved specific inhibition ...

Proteinase-activated receptors 2 (PAR2) are expressed in kidney, but their function is mostly unknown. Since PAR2 control ion transport in several epithelia, we searched for an effect on sodium transport in the cortical thick ascending limb of Henle's loop, a nephron segment that avidly reabsorbs NaCl, and for its signaling. Activation of ...

Hemostasis is a defense mechanism which protects the organism in the event of injury to stop bleeding. Recently, we established that all the known major mammalian hemostatic factors are conserved in early vertebrates. However, since their highly vascularized gills experience high blood pressure and are exposed to the environment, even very small injuries could be fatal to fish. Since trypsins are ...

BackgroundDisseminated dormant cancer cells can resume growth and eventually form overt metastases, but the underlying molecular mechanism responsible for this change remains obscure. We previously established that cell surface interaction between urokinase receptor (uPAR) and ?5?1-integrin initiates a sequel of events, involving MAPK-ERK activation that culminates in ...

BackgroundThe urokinase receptor (uPAR/CD87) is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA) and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling ...

Background and Purpose:Protease-activated receptor-2 (PAR-2) is expressed on lymphocytes and endothelial cells, and plays a significant role in inflammatory reactions. Since leukocyte-endothelial cell interaction and reactive oxygen species (ROS) generation are hallmarks of the development of inflammation, the effects of PAR-2 activation by trypsin on ...

Objectif : D�gager les points d'accord et de divergence relatifs aux antipsychotiques. Depuis l'apparition des antipsychotiques d'action prolong�e (APAP) de 2e g�n�ration et vu la fr�quence �lev�e de la non-observance aux antipsychotiques dans les troubles psychotiques, les APAP suscitent une recrudescence d'int�r�t dans la litt�rature psychiatrique. ...

BackgroundThe differences in total hip arthroplasty (THA) survivorship may be influenced by individual susceptibility to periprosthetic osteolysis. This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype.MethodsWe performed a study on 22 ...

Objective:To assess prevalence, potential risk factors and population attributable risk percentage (PAR%) for diabetic retinopathy (DR) in the Indian state of Andhra Pradesh.Methods:A population-based study, using a stratified, random, cluster, systematic sampling strategy, was conducted in the state of Andhra Pradesh in India during 1996 and 2000. Participants from 94 ...

BackgroundCyr61 is a member of the CCN (Cyr61, connective tissue growth, NOV) family of extracellular-associated (matricellular) proteins that present four distinct functional modules, namely insulin-like growth factor binding protein (IGFBP), von Willebrand factor type C (vWF), thrombospondin type 1 (TSP), and C-terminal growth factor cysteine knot (CT) domain. While heparin sulphate ...

BackgroundThe neonatal bovine mammary fat pad (MFP) surrounding the mammary parenchyma (PAR) is thought to exert proliferative effects on the PAR through secretion of local modulators of growth induced by systemic hormones. We used bioinformatics to characterize transcriptomics differences between PAR and MFP from ~65 d old Holstein ...

The mechanism of the formation of the swellability index of coals is considered, and the conclusion is drawn that it is basically nonadditive. A formula is given for calculating the swellability of coals and charges according to the yield of volatile matter and the viscosity of the plastic mass.

... at all. Conclusions: The experiment confirms the high stability of Corynephorus grassland vegetation. Most vegetation changes are in accordance with the hypothetical series of successional phases. In contr...

An extensive international research on the quick methods for the study of fatigue in steels, was carried out. The results are analyzed according to the Locati and Prot methods. The effects of the operative variables are evidenced and some conclusions are ...