Sample records for account reporting lags

  1. A multi-source data assimilation framework for flood forecasting: Accounting for runoff routing lags

    NASA Astrophysics Data System (ADS)

    Meng, S.; Xie, X.

    2015-12-01

    In the flood forecasting practice, model performance is usually degraded due to various sources of uncertainties, including the uncertainties from input data, model parameters, model structures and output observations. Data assimilation is a useful methodology to reduce uncertainties in flood forecasting. For the short-term flood forecasting, an accurate estimation of initial soil moisture condition will improve the forecasting performance. Considering the time delay of runoff routing is another important effect for the forecasting performance. Moreover, the observation data of hydrological variables (including ground observations and satellite observations) are becoming easily available. The reliability of the short-term flood forecasting could be improved by assimilating multi-source data. The objective of this study is to develop a multi-source data assimilation framework for real-time flood forecasting. In this data assimilation framework, the first step is assimilating the up-layer soil moisture observations to update model state and generated runoff based on the ensemble Kalman filter (EnKF) method, and the second step is assimilating discharge observations to update model state and runoff within a fixed time window based on the ensemble Kalman smoother (EnKS) method. This smoothing technique is adopted to account for the runoff routing lag. Using such assimilation framework of the soil moisture and discharge observations is expected to improve the flood forecasting. In order to distinguish the effectiveness of this dual-step assimilation framework, we designed a dual-EnKF algorithm in which the observed soil moisture and discharge are assimilated separately without accounting for the runoff routing lag. The results show that the multi-source data assimilation framework can effectively improve flood forecasting, especially when the runoff routing has a distinct time lag. Thus, this new data assimilation framework holds a great potential in operational flood

  2. Internet and free press are associated with reduced lags in global outbreak reporting.

    PubMed

    McAlarnen, Lindsey; Smith, Katherine; Brownstein, John S; Jerde, Christopher

    2014-10-30

    Global outbreak detection and reporting have generally improved for a variety of infectious diseases and geographic regions in recent decades. Nevertheless, lags in outbreak reporting remain a threat to the global human health and economy. In the time between first occurrence of a novel disease incident and public notification of an outbreak, infected individuals have a greater possibility of traveling and spreading the pathogen to other nations. Shortening outbreak reporting lags has the potential to improve global health by preventing local outbreaks from escalating into global epidemics. Reporting lags between the first record and the first public report of an event were calculated for 318 outbreaks occurring 1996-2009. The influence of freedom of the press, Internet usage, per capita health expenditure, and cell phone subscriptions, on the timeliness of outbreak reporting was evaluated. Freer presses and increasing Internet usage correlate with reduced time between the first record of an outbreak and the public report. Increasing Internet usage reduced the expected reporting lag from more than one month in nations without Internet users to one day in those where 75 of 100 people use the Internet. Advances in technology and the emergence of more open and free governments are associated with to improved global infectious disease surveillance.

  3. The buzz-lag effect.

    PubMed

    Cellini, Cristiano; Scocchia, Lisa; Drewing, Knut

    2016-10-01

    In the flash-lag illusion, a brief visual flash and a moving object presented at the same location appear to be offset with the flash trailing the moving object. A considerable amount of studies investigated the visual flash-lag effect, and flash-lag-like effects have also been observed in audition, and cross-modally between vision and audition. In the present study, we investigate whether a similar effect can also be observed when using only haptic stimuli. A fast vibration (or buzz, lasting less than 20 ms) was applied to the moving finger of the observers and employed as a "haptic flash." Participants performed a two-alternative forced-choice (2AFC) task where they had to judge whether the moving finger was located to the right or to the left of the stationary finger at the time of the buzz. We used two different movement velocities (Slow and Fast conditions). We found that the moving finger was systematically misperceived to be ahead of the stationary finger when the two were physically aligned. This result can be interpreted as a purely haptic analogue of the flash-lag effect, which we refer to as "buzz-lag effect." The buzz-lag effect can be well accounted for by the temporal-sampling explanation of flash-lag-like effects.

  4. Why Do Rereading Lag Effects Depend on Test Delay?

    ERIC Educational Resources Information Center

    Rawson, Katherine A.

    2012-01-01

    In previous research, rereading after a long lag versus a short lag led to greater performance on delayed tests but not on immediate tests. The current study tested two accounts of why the effects of rereading lag depend on test delay. The "levels of representation" ("LOR") "hypothesis" states that the effects reflect…

  5. The effect of bifocal add on accommodative lag in myopic children with high accommodative lag.

    PubMed

    Berntsen, David A; Mutti, Donald O; Zadnik, Karla

    2010-12-01

    To determine the effect of a bifocal add and manifest correction on accommodative lag in myopic children with high accommodative lag, who have been reported to have the greatest reduction in myopia progression with progressive addition lenses (PALs). Monocular accommodative lag to a 4-D Badal stimulus was measured on two occasions 6 months apart in 83 children (mean ± SD age, 9.9 ± 1.3 years) with high lag randomized to wearing single-vision lenses (SVLs) or PALs. Accommodative lag was measured with the following corrections: habitual, manifest, manifest with +2.00-D add, and habitual with +2.00-D add (6-month visit only). At baseline, accommodative lag was higher (1.72 ± 0.37 D; mean ± SD) when measured with manifest correction than with habitual correction (1.51 ± 0.50; P < 0.05). This higher lag with manifest correction correlated with a larger amount of habitual undercorrection at baseline (r = -0.29, P = 0.009). A +2.00-D add over the manifest correction reduced lag by 0.45 ± 0.34 D at baseline and 0.33 ± 0.38 D at the 6-month visit. Lag results at 6 months were not different between PAL and SVL wearers (P = 0.92). A +2.00-D bifocal add did not eliminate accommodative lag and reduced lag by less than 25% of the bifocal power, indicating that children mainly responded to a bifocal by decreasing accommodation. If myopic progression is substantial, measuring lag with full correction can overestimate the hyperopic retinal blur that a child most recently experienced. (ClinicalTrials.gov number, NCT00335049.).

  6. The Effect of Bifocal Add on Accommodative Lag in Myopic Children with High Accommodative Lag

    PubMed Central

    Mutti, Donald O.; Zadnik, Karla

    2010-01-01

    Purpose. To determine the effect of a bifocal add and manifest correction on accommodative lag in myopic children with high accommodative lag, who have been reported to have the greatest reduction in myopia progression with progressive addition lenses (PALs). Methods. Monocular accommodative lag to a 4-D Badal stimulus was measured on two occasions 6 months apart in 83 children (mean ± SD age, 9.9 ± 1.3 years) with high lag randomized to wearing single-vision lenses (SVLs) or PALs. Accommodative lag was measured with the following corrections: habitual, manifest, manifest with +2.00-D add, and habitual with +2.00-D add (6-month visit only). Results. At baseline, accommodative lag was higher (1.72 ± 0.37 D; mean ± SD) when measured with manifest correction than with habitual correction (1.51 ± 0.50; P < 0.05). This higher lag with manifest correction correlated with a larger amount of habitual undercorrection at baseline (r = −0.29, P = 0.009). A +2.00-D add over the manifest correction reduced lag by 0.45 ± 0.34 D at baseline and 0.33 ± 0.38 D at the 6-month visit. Lag results at 6 months were not different between PAL and SVL wearers (P = 0.92). Conclusions. A +2.00-D bifocal add did not eliminate accommodative lag and reduced lag by less than 25% of the bifocal power, indicating that children mainly responded to a bifocal by decreasing accommodation. If myopic progression is substantial, measuring lag with full correction can overestimate the hyperopic retinal blur that a child most recently experienced. (ClinicalTrials.gov number, NCT00335049.) PMID:20688729

  7. A critique of the cross-lagged panel model.

    PubMed

    Hamaker, Ellen L; Kuiper, Rebecca M; Grasman, Raoul P P P

    2015-03-01

    The cross-lagged panel model (CLPM) is believed by many to overcome the problems associated with the use of cross-lagged correlations as a way to study causal influences in longitudinal panel data. The current article, however, shows that if stability of constructs is to some extent of a trait-like, time-invariant nature, the autoregressive relationships of the CLPM fail to adequately account for this. As a result, the lagged parameters that are obtained with the CLPM do not represent the actual within-person relationships over time, and this may lead to erroneous conclusions regarding the presence, predominance, and sign of causal influences. In this article we present an alternative model that separates the within-person process from stable between-person differences through the inclusion of random intercepts, and we discuss how this model is related to existing structural equation models that include cross-lagged relationships. We derive the analytical relationship between the cross-lagged parameters from the CLPM and the alternative model, and use simulations to demonstrate the spurious results that may arise when using the CLPM to analyze data that include stable, trait-like individual differences. We also present a modeling strategy to avoid this pitfall and illustrate this using an empirical data set. The implications for both existing and future cross-lagged panel research are discussed. (c) 2015 APA, all rights reserved).

  8. Jet-lag: prevention with Pycnogenol. Preliminary report: evaluation in healthy individuals and in hypertensive patients.

    PubMed

    Belcaro, G; Cesarone, M R; Steigerwalt, R J; Di Renzo, A; Grossi, M G; Ricci, A; Stuard, S; Ledda, A; Dugall, M; Cornelli, U; Cacchio, M

    2008-10-01

    This study was conducted with the aim of showing the effects of Pycnogenol on controlling jet-lag symptoms. Oral Pycnogenol, 50 mg tablets 3 times/die, for 7 days starting 2 days prior to the flight was used. The study was divided into two separate parts. In study 1 the most common complaints of patients with jet-lag were evaluated with a rating scale consisting in of a scoring system. In study 2 a brain CT scan was performed after the flight in order to assess minimal brain edema (MBE) in association with typical signs and symptoms, observed in previous published flight studies. Study one included 38 subjects treated with Pycnogenol and 30 controls. The symptomatic jet-lag related total score was significantly lower (indicating a lower level of jet-lag) in the Pycnogenol group. The average duration of any jet lag symptom following the flight was significantly reduced from 39.3 (SD=0.8) hours in controls to an average of 18.2 (SD=3.3) hours in the Pycnogenol group (P<0.05). Study 2 included 34 subjects treated with Pycnogenol and 31 controls. The main observation was the brain CT scan performed within 28 hours after the end of the flight. The difference between the Pycnogenol and the control groups was statistically significant (P<0.05) for all items assessed including the cerebral edema score obtained by CT scan. The short-term memory was significantly altered in the control group and associated to edema and swelling of the lower limbs. The score (and the level of edema) was comparatively higher in a subgroup of hypertensive subjects in the control group. Minor alterations of cardiac function were observed in association with de-stabilisation of blood pressure. Fatigue was also significantly higher in the control group in comparison with the Pycnogenol group. A number of spontaneously reported symptoms was also scored and there was a statistically significant difference (P<0.05) between the Pycnogenol and control groups. In conlusion, Pycnogenol was useful to

  9. How jet lag impairs Major League Baseball performance.

    PubMed

    Song, Alex; Severini, Thomas; Allada, Ravi

    2017-02-07

    Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock. Surprisingly, we found that jet lag impaired major parameters of home-team offensive performance, for example, slugging percentage, but did not similarly affect away-team offensive performance. On the other hand, jet lag impacted both home and away defensive performance. Remarkably, the vast majority of these effects for both home and away teams could be explained by a single measure, home runs allowed. Rather than uniform effects, these results reveal surprisingly specific effects of circadian misalignment on athletic performance under natural conditions.

  10. Implications of Lag-Luminosity Relationship for Unified GRB Paradigms

    NASA Technical Reports Server (NTRS)

    Norris, J. P.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    Spectral lags (tau(sub lag)) are deduced for 1437 long (T(sub 90) greater than 2 s) BATSE gamma-ray bursts (GRBs) with peak flux F(sub p) greater than 0.25 photons cm(sup -2)/s, near to the BATSE trigger threshold. The lags are modeled to approximate the observed distribution in the F(sub p)-T(sub lag) plane, realizing a noise-free representation. Assuming a two-branch lag-luminosity relationship, the lags are self-consistently corrected for cosmological effects to yield distributions in luminosity, distance, and redshift. The results have several consequences for GRB populations and for unified gamma-ray/afterglow scenarios which would account for afterglow break times and gamma-ray spectral evolution in terms of jet opening angle, viewing angle, or a profiled jet with variable Lorentz factor: A component of the burst sample is identified - those with few, wide pulses, lags of a few tenths to several seconds, and soft spectra - whose Log[N]-Log[F(sub p)] distribution approximates a -3/2 power-law, suggesting homogeneity and thus relatively nearby sources. The proportion of these long-lag bursts increases from negligible among bright BATSE bursts to approx. 50% at trigger threshold. Bursts with very long lags, approx. 1-2 less than tau(sub lag) (S) less than 10, show a tendency to concentrate near the Supergalactic Plane with a quadrupole moment of approx. -0.10 +/- 0.04. GRB 980425 (SN 1998bw) is a member of this subsample of approx. 90 bursts with estimated distances less than 100 Mpc. The frequency of the observed ultra-low luminosity bursts is approx. 1/4 that of SNe Ib/c within the same volume. If truly nearby, the core-collapse events associated with these GRBs might produce gravitational radiation detectable by LIGO-II. Such nearby bursts might also help explain flattening of the cosmic ray spectrum at ultra-high energies, as observed by AGASA.

  11. Lags in the response of mountain plant communities to climate change.

    PubMed

    Alexander, Jake M; Chalmandrier, Loïc; Lenoir, Jonathan; Burgess, Treena I; Essl, Franz; Haider, Sylvia; Kueffer, Christoph; McDougall, Keith; Milbau, Ann; Nuñez, Martin A; Pauchard, Aníbal; Rabitsch, Wolfgang; Rew, Lisa J; Sanders, Nathan J; Pellissier, Loïc

    2018-02-01

    Rapid climatic changes and increasing human influence at high elevations around the world will have profound impacts on mountain biodiversity. However, forecasts from statistical models (e.g. species distribution models) rarely consider that plant community changes could substantially lag behind climatic changes, hindering our ability to make temporally realistic projections for the coming century. Indeed, the magnitudes of lags, and the relative importance of the different factors giving rise to them, remain poorly understood. We review evidence for three types of lag: "dispersal lags" affecting plant species' spread along elevational gradients, "establishment lags" following their arrival in recipient communities, and "extinction lags" of resident species. Variation in lags is explained by variation among species in physiological and demographic responses, by effects of altered biotic interactions, and by aspects of the physical environment. Of these, altered biotic interactions could contribute substantially to establishment and extinction lags, yet impacts of biotic interactions on range dynamics are poorly understood. We develop a mechanistic community model to illustrate how species turnover in future communities might lag behind simple expectations based on species' range shifts with unlimited dispersal. The model shows a combined contribution of altered biotic interactions and dispersal lags to plant community turnover along an elevational gradient following climate warming. Our review and simulation support the view that accounting for disequilibrium range dynamics will be essential for realistic forecasts of patterns of biodiversity under climate change, with implications for the conservation of mountain species and the ecosystem functions they provide. © 2017 John Wiley & Sons Ltd.

  12. 17 CFR 210.2-02 - Accountants' reports and attestation reports.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Accountants' reports and... AND CONSERVATION ACT OF 1975 Qualifications and Reports of Accountants § 210.2-02 Accountants' reports and attestation reports. (a) Technical requirements for accountants' reports. The accountant's report...

  13. 17 CFR 210.2-02 - Accountants' reports and attestation reports.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Accountants' reports and... AND CONSERVATION ACT OF 1975 Qualifications and Reports of Accountants § 210.2-02 Accountants' reports and attestation reports. (a) Technical requirements for accountants' reports. The accountant's report...

  14. 17 CFR 210.2-02 - Accountants' reports and attestation reports.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Accountants' reports and... AND CONSERVATION ACT OF 1975 Qualifications and Reports of Accountants § 210.2-02 Accountants' reports and attestation reports. (a) Technical requirements for accountants' reports. The accountant's report...

  15. Spacing and lag effects in free recall of pure lists.

    PubMed

    Kahana, Michael J; Howard, Marc W

    2005-02-01

    Repeating list items leads to better recall when the repetitions are separated by several unique items than when they are presented successively; the spacing effect refers to improved recall for spaced versus successive repetition (lag > 0 vs. lag = 0); the lag effect refers to improved recall for long lags versus short lags. Previous demonstrations of the lag effect have utilized lists containing a mixture of items with varying degrees of spacing. Because differential rehearsal of items in mixed lists may exaggerate any effects of spacing, it is important to demonstrate these effects in pure lists. As in Toppino and Schneider (1999), we found an overall advantage for recall of spaced lists. We further report the first demonstration of a lag effect in pure lists, with significantly better recall for lists with widely spaced repetitions than for those with moderately spaced repetitions.

  16. 17 CFR 210.2-02 - Accountants' reports and attestation reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Accountants' reports and... Accountants § 210.2-02 Accountants' reports and attestation reports. (a) Technical requirements for accountants' reports. The accountant's report: (1) Shall be dated; (2) Shall be signed manually; (3) Shall...

  17. How jet lag impairs Major League Baseball performance

    PubMed Central

    Song, Alex; Severini, Thomas; Allada, Ravi

    2017-01-01

    Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock. Surprisingly, we found that jet lag impaired major parameters of home-team offensive performance, for example, slugging percentage, but did not similarly affect away-team offensive performance. On the other hand, jet lag impacted both home and away defensive performance. Remarkably, the vast majority of these effects for both home and away teams could be explained by a single measure, home runs allowed. Rather than uniform effects, these results reveal surprisingly specific effects of circadian misalignment on athletic performance under natural conditions. PMID:28115724

  18. Statistical properties of Fourier-based time-lag estimates

    NASA Astrophysics Data System (ADS)

    Epitropakis, A.; Papadakis, I. E.

    2016-06-01

    observed time series; b) smoothing of the cross-periodogram should be avoided, as this may introduce significant bias to the time-lag estimates, which can be taken into account by assuming a model cross-spectrum (and not just a model time-lag spectrum); c) time-lags should be estimated by dividing observed time series into a number, say m, of shorter data segments and averaging the resulting cross-periodograms; d) if the data segments have a duration ≳ 20 ks, the time-lag bias is ≲15% of its intrinsic value for the model cross-spectra and power-spectra considered in this work. This bias should be estimated in practise (by considering possible intrinsic cross-spectra that may be applicable to the time-lag spectra at hand) to assess the reliability of any time-lag analysis; e) the effects of experimental noise can be minimised by only estimating time-lags in the frequency range where the sample coherence is larger than 1.2/(1 + 0.2m). In this range, the amplitude of noise variations caused by measurement errors is smaller than the amplitude of the signal's intrinsic variations. As long as m ≳ 20, time-lags estimated by averaging over individual data segments have analytical error estimates that are within 95% of the true scatter around their mean, and their distribution is similar, albeit not identical, to a Gaussian.

  19. Why does lag affect the durability of memory-based automaticity: loss of memory strength or interference?

    PubMed

    Wilkins, Nicolas J; Rawson, Katherine A

    2013-10-01

    In Rickard, Lau, and Pashler's (2008) investigation of the lag effect on memory-based automaticity, response times were faster and proportion of trials retrieved was higher at the end of practice for short lag items than for long lag items. However, during testing after a delay, response times were slower and proportion of trials retrieved was lower for short lag items than for long lag items. The current study investigated the extent to which the lag effect on the durability of memory-based automaticity is due to interference or to the loss of memory strength with time. Participants repeatedly practiced alphabet subtraction items in short lag and long lag conditions. After practice, half of the participants were immediately tested and the other half were tested after a 7-day delay. Results indicate that the lag effect on the durability of memory-based automaticity is primarily due to interference. We discuss potential modification of current memory-based processing theories to account for these effects. © 2013.

  20. Mechanisms of Zero-Lag Synchronization in Cortical Motifs

    PubMed Central

    Gollo, Leonardo L.; Mirasso, Claudio; Sporns, Olaf; Breakspear, Michael

    2014-01-01

    Zero-lag synchronization between distant cortical areas has been observed in a diversity of experimental data sets and between many different regions of the brain. Several computational mechanisms have been proposed to account for such isochronous synchronization in the presence of long conduction delays: Of these, the phenomenon of “dynamical relaying” – a mechanism that relies on a specific network motif – has proven to be the most robust with respect to parameter mismatch and system noise. Surprisingly, despite a contrary belief in the community, the common driving motif is an unreliable means of establishing zero-lag synchrony. Although dynamical relaying has been validated in empirical and computational studies, the deeper dynamical mechanisms and comparison to dynamics on other motifs is lacking. By systematically comparing synchronization on a variety of small motifs, we establish that the presence of a single reciprocally connected pair – a “resonance pair” – plays a crucial role in disambiguating those motifs that foster zero-lag synchrony in the presence of conduction delays (such as dynamical relaying) from those that do not (such as the common driving triad). Remarkably, minor structural changes to the common driving motif that incorporate a reciprocal pair recover robust zero-lag synchrony. The findings are observed in computational models of spiking neurons, populations of spiking neurons and neural mass models, and arise whether the oscillatory systems are periodic, chaotic, noise-free or driven by stochastic inputs. The influence of the resonance pair is also robust to parameter mismatch and asymmetrical time delays amongst the elements of the motif. We call this manner of facilitating zero-lag synchrony resonance-induced synchronization, outline the conditions for its occurrence, and propose that it may be a general mechanism to promote zero-lag synchrony in the brain. PMID:24763382

  1. 10 CFR 75.33 - Accounting reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Accounting reports. 75.33 Section 75.33 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Reports § 75.33 Accounting reports. (a)(1) The accounting reports for each IAEA material balance area must...

  2. 10 CFR 75.33 - Accounting reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Accounting reports. 75.33 Section 75.33 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Reports § 75.33 Accounting reports. (a)(1) The accounting reports for each IAEA material balance area must...

  3. The shear-lag effect of thin-walled box girder under vertical earthquake excitation

    NASA Astrophysics Data System (ADS)

    Zhai, Zhipeng; Li, Yaozhuang; Guo, Wei

    2017-03-01

    The variation method based on the energy variation principle is proved to be accurate and valid for analyzing the shear lag effect of box girder under static and dynamic load. Meanwhile, dynamic problems gradually become the key factors in engineering practice. Therefore, a method for calculating the shear lag effect in thin-walled box girder under vertical seismic excitation is proposed by applying Hamilton Principle in this paper. The Timoshenko shear deformation is taken into account. And a new definition of shear lag ratio for box girder is given. What's more, some conclusions are drawn by analysis of numerical example. The results show that small amplitude of earthquake ground motion can generate high stress and obvious shear lag, especially in the region of resonance. And the influence of rotary inertia cannot be ignored for analyzing the shear lag effect. With the increase of span to width ratio, shear lag effect becomes smaller and smaller. These research conclusions will be useful for the engineering practice and enrich the theoretical studies of box girders.

  4. When Long-Range Zero-Lag Synchronization is Feasible in Cortical Networks

    PubMed Central

    Viriyopase, Atthaphon; Bojak, Ingo; Zeitler, Magteld; Gielen, Stan

    2012-01-01

    Many studies have reported long-range synchronization of neuronal activity between brain areas, in particular in the beta and gamma bands with frequencies in the range of 14–30 and 40–80 Hz, respectively. Several studies have reported synchrony with zero phase lag, which is remarkable considering the synaptic and conduction delays inherent in the connections between distant brain areas. This result has led to many speculations about the possible functional role of zero-lag synchrony, such as for neuronal communication, attention, memory, and feature binding. However, recent studies using recordings of single-unit activity and local field potentials report that neuronal synchronization may occur with non-zero phase lags. This raises the questions whether zero-lag synchrony can occur in the brain and, if so, under which conditions. We used analytical methods and computer simulations to investigate which connectivity between neuronal populations allows or prohibits zero-lag synchrony. We did so for a model where two oscillators interact via a relay oscillator. Analytical results and computer simulations were obtained for both type I Mirollo–Strogatz neurons and type II Hodgkin–Huxley neurons. We have investigated the dynamics of the model for various types of synaptic coupling and importantly considered the potential impact of Spike-Timing Dependent Plasticity (STDP) and its learning window. We confirm previous results that zero-lag synchrony can be achieved in this configuration. This is much easier to achieve with Hodgkin–Huxley neurons, which have a biphasic phase response curve, than for type I neurons. STDP facilitates zero-lag synchrony as it adjusts the synaptic strengths such that zero-lag synchrony is feasible for a much larger range of parameters than without STDP. PMID:22866034

  5. Intramedullary nails with two lag screws.

    PubMed

    Brown, C J; Wang, C J; Yettram, A L; Procter, P

    2004-06-01

    To investigate the structural integrity of intramedullary nails with two lag screws, and to give guidance to orthopaedic surgeons in the choice of appropriate devices. Alternative designs of the construct are considered, and the use of a slotted upper lag screw insertion hole is analysed. Intramedullary fixation devices with a single lag screw have been known to fail at the lag screw insertion hole. Using two lag screws is considered. It has also been proposed to use a slot in the nail for the upper lag screw to prevent the upper lag screw from sticking. Bending and torsion load cases are analysed using finite element method. Consideration of both load conditions is essential. The results present the overall stiffness of the assembly, the load sharing between lag screws, and the possibility for cut-out to occur. While the slot for the upper lag screw might be advantageous with regard to the stresses in the lag screws, it could be detrimental for cut-out occurring adjacent to the lag screws. Comparative analyses demonstrate that two lag screws may be advantageous in patients whose cancellous bone quality is good and who impose large loads on the lag screw/nail interface. However, the use of two screws might pre-dispose to failure by cut-out of the lag screws. The addition of a slotted hole for the upper lag screw appears to do nothing significant to reduce the risk of such a failure. Copyright 2004 Elsevier Ltd.

  6. Lag and anticipating synchronization without time-delay coupling.

    PubMed

    Corron, Ned J; Blakely, Jonathan N; Pethel, Shawn D

    2005-06-01

    We describe a new method for achieving approximate lag and anticipating synchronization in unidirectionally coupled chaotic oscillators. The method uses a specific parameter mismatch between the drive and response that is a first-order approximation to true time-delay coupling. As a result, an adjustable lag or anticipation effect can be achieved without the need for a variable delay line, making the method simpler and more economical to implement in many physical systems. We present a stability analysis, demonstrate the method numerically, and report experimental observation of the effect in radio-frequency electronic oscillators. In the circuit experiments, both lag and anticipation are controlled by tuning a single capacitor in the response oscillator.

  7. The dream-lag effect: Selective processing of personally significant events during Rapid Eye Movement sleep, but not during Slow Wave Sleep.

    PubMed

    van Rijn, E; Eichenlaub, J-B; Lewis, P A; Walker, M P; Gaskell, M G; Malinowski, J E; Blagrove, M

    2015-07-01

    Incorporation of details from waking life events into Rapid Eye Movement (REM) sleep dreams has been found to be highest on the night after, and then 5-7 nights after events (termed, respectively, the day-residue and dream-lag effects). In experiment 1, 44 participants kept a daily log for 10 days, reporting major daily activities (MDAs), personally significant events (PSEs), and major concerns (MCs). Dream reports were collected from REM and Slow Wave Sleep (SWS) in the laboratory, or from REM sleep at home. The dream-lag effect was found for the incorporation of PSEs into REM dreams collected at home, but not for MDAs or MCs. No dream-lag effect was found for SWS dreams, or for REM dreams collected in the lab after SWS awakenings earlier in the night. In experiment 2, the 44 participants recorded reports of their spontaneously recalled home dreams over the 10 nights following the instrumental awakenings night, which thus acted as a controlled stimulus with two salience levels, high (sleep lab) and low (home awakenings). The dream-lag effect was found for the incorporation into home dreams of references to the experience of being in the sleep laboratory, but only for participants who had reported concerns beforehand about being in the sleep laboratory. The delayed incorporation of events from daily life into dreams has been proposed to reflect REM sleep-dependent memory consolidation. However, an alternative emotion processing or emotional impact of events account, distinct from memory consolidation, is supported by the finding that SWS dreams do not evidence the dream-lag effect. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Lags in the response of mountain plant communities to climate change

    PubMed Central

    Alexander, Jake M.; Chalmandrier, Loïc; Lenoir, Jonathan; Burgess, Treena I.; Essl, Franz; Haider, Sylvia; Kueffer, Christoph; McDougall, Keith; Milbau, Ann; Nuñez, Martin A.; Pauchard, Aníbal; Rabitsch, Wolfgang; Rew, Lisa J.; Sanders, Nathan J.; Pellissier, Loïc

    2018-01-01

    Rapid climatic changes and increasing human influence at high elevations around the world will have profound impacts on mountain biodiversity. However, forecasts from statistical models (e.g. species distribution models) rarely consider that plant community changes could substantially lag behind climatic changes, hindering our ability to make temporally realistic projections for the coming century. Indeed, the magnitudes of lags, and the relative importance of the different factors giving rise to them, remain poorly understood. We review evidence for three types of lag: “dispersal lags” affecting plant species’ spread along elevational gradients, “establishment lags” following their arrival in recipient communities, and “extinction lags” of resident species. Variation in lags is explained by variation among species in physiological and demographic responses, by effects of altered biotic interactions, and by aspects of the physical environment. Of these, altered biotic interactions could contribute substantially to establishment and extinction lags, yet impacts of biotic interactions on range dynamics are poorly understood. We develop a mechanistic community model to illustrate how species turnover in future communities might lag behind simple expectations based on species’ range shifts with unlimited dispersal. The model shows a combined contribution of altered biotic interactions and dispersal lags to plant community turnover along an elevational gradient following climate warming. Our review and simulation support the view that accounting for disequilibrium range dynamics will be essential for realistic forecasts of patterns of biodiversity under climate change, with implications for the conservation of mountain species and the ecosystem functions they provide. PMID:29112781

  9. Lag and seasonality considerations in evaluating AVHRR NDVI response to precipitation

    USGS Publications Warehouse

    Ji, Lei; Peters, Albert J.

    2005-01-01

    Assessment of the relationship between the normalized difference vegetation index (NDVI) and precipitation is important in understanding vegetation and climate interaction at a large scale. NDVI response to precipitation, however, is difficult to quantify due to the lag and seasonality effects, which will vary due to vegetation cover type, soils and climate. A time series analysis was performed on biweekly NDVI and precipitation around weather stations in the northern and central U.S. Great Plains. Regression models that incorporate lag and seasonality effects were used to quantify the relationship between NDVI and lagged precipitation in grasslands and croplands. It was found that the time lag was shorter in the early growing season, but longer in the mid- to late-growing season for most locations. The regression models with seasonal adjustment indicate that the relationship between NDVI and precipitation over the entire growing season was strong, with R2 values of 0.69 and 0.72 for grasslands and croplands, respectively. We conclude that vegetation greenness can be predicted using current and antecedent precipitation, if seasonal effects are taken into account.

  10. SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bizyaev, D.; Pan, K.; Brinkmann, J.

    2017-04-20

    We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed H α emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the verticalmore » lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.« less

  11. SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

    NASA Astrophysics Data System (ADS)

    Bizyaev, D.; Walterbos, R. A. M.; Yoachim, P.; Riffel, R. A.; Fernández-Trincado, J. G.; Pan, K.; Diamond-Stanic, A. M.; Jones, A.; Thomas, D.; Cleary, J.; Brinkmann, J.

    2017-04-01

    We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed Hα emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

  12. On the thermal runaway of combustible fluids in lagging material

    NASA Astrophysics Data System (ADS)

    McIntosh, A. C.; Griffiths, J. F.

    1995-01-01

    This paper presents the mathematical foundations for a simple theory for investigating the phenomenon of ignition of flammable fluids in lagging material that are used for insulation of hot pipework, for transport of heat transfer fluids, or other similar situations. Experiments with porous material impregnated with a flammable fluid have simulated the self-heating known to occur when combustible liquids leak from a hot pipe into lagging surrounding the pipe or are split from another source on to the lagging. A theory to explain these findings is presented which shows that there is a watershed temperature beyond which substantial self-heating will take place. Although the theory does not take account of diffusion, it simulates the main physics of the phenomenon-that is, combustible fluid, which normally in the open air would evaporate and not be a hazard, can, within a porous medium, remain dispersed within the porous structure long enough for the exothermic oxidation to develop into ignition.

  13. Effect of phase lag on cyclic durability of laminated composite

    NASA Astrophysics Data System (ADS)

    Andersons, Janis; Limonov, V.; Tamuzs, Vitants

    1992-07-01

    Theoretical and experimental results on fatigue of laminated fiber reinforced composites under out-of-phase, biaxial cyclic loading are presented. Experiments were carried out on tubular filament wound samples of epoxy matrix/organic (Kevlar type) fiber composites. Fatigue strength under two different loading modes, namely cyclic torsion combined with axial tension or compression, was investigated for phase lags psi = 0, pi/2, and pi. Durability was shown to decrease with increasing phase shift both for axial tension (R = 0.1) and compression (R = 10). A matrix failure criterion was proposed for a unidirectionally reinforced ply, and the ply discount method was modified to account for phase lag. Calculated S-N curves agree reasonably well with experimental data.

  14. Accountability report - fiscal year 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-04-01

    This document contains the US NRC`s accountability report for fiscal year 1997. Topics include uses of funds, financial condition, program performance, management accountability, and the audited financial statement.

  15. 31 CFR 281.8 - Reporting and accounting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Reporting and accounting. 281.8 Section 281.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... Reporting and accounting. The Treasury Department will maintain a system of central accounting and reporting...

  16. 7 CFR 993.173 - Reports of accounting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Reports of accounting. 993.173 Section 993.173... accounting. (a) Independent handler's reports of accounting. Within 10 days (exclusive of Saturdays, Sundays... association, makes an accounting or settlement with a producer or dehydrator for prunes delivered to him, he...

  17. ARTS. Accountability Reporting and Tracking System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jones, J.F.; Faccio, R.M.

    ARTS is a micro based prototype of the data elements, screens, and information processing rules that apply to the Accountability Reporting Program. The system focuses on the Accountability Event. The Accountability Event is an occurrence of incurring avoidable costs. The system must be able to CRUD (Create, Retrieve, Update, Delete) instances of the Accountability Event. Additionally, the system must provide for a review committee to update the `event record` with findings and determination information. Lastly, the system must provide for financial representatives to perform a cost reporting process.

  18. Effect of lag time distribution on the lag phase of bacterial growth - a Monte Carlo analysis

    USDA-ARS?s Scientific Manuscript database

    The objective of this study is to use Monte Carlo simulation to evaluate the effect of lag time distribution of individual bacterial cells incubated under isothermal conditions on the development of lag phase. The growth of bacterial cells of the same initial concentration and mean lag phase durati...

  19. A way around the Nyquist lag

    NASA Astrophysics Data System (ADS)

    Penland, C.

    2017-12-01

    One way to test for the linearity of a multivariate system is to perform Linear Inverse Modeling (LIM) to a multivariate time series. LIM yields an estimated operator by combining a lagged covariance matrix with the contemporaneous covariance matrix. If the underlying dynamics is linear, the resulting dynamical description should not depend on the particular lag at which the lagged covariance matrix is estimated. This test is known as the "tau test." The tau test will be severely compromised if the lag at which the analysis is performed is approximately half the period of an internal oscillation frequency. In this case, the tau test will fail even though the dynamics are actually linear. Thus, until now, the tau test has only been possible for lags smaller than this "Nyquist lag." In this poster, we investigate the use of Hilbert transforms as a way to avoid the problems associated with Nyquist lags. By augmenting the data with dimensions orthogonal to those spanning the original system, information that would be inaccessible to LIM in its original form may be sampled.

  20. Contractor Accounting, Reporting and Estimating (CARE).

    DTIC Science & Technology

    Contractor Accounting Reporting and Estimating (CARE) provides check lists that may be used as guides in evaluating the accounting system, financial reporting , and cost estimating capabilities of the contractor. Experience gained from the Management Review Technique was used as a basis for the check lists. (Author)

  1. SARS: Safeguards Accounting and Reporting Software

    NASA Astrophysics Data System (ADS)

    Mohammedi, B.; Saadi, S.; Ait-Mohamed, S.

    In order to satisfy the requirements of the SSAC (State System for Accounting and Control of nuclear materials), for recording and reporting objectives; this computer program comes to bridge the gape between nuclear facilities operators and national inspection verifying records and delivering reports. The SARS maintains and generates at-facility safeguards accounting records and generates International Atomic Energy Agency (IAEA) safeguards reports based on accounting data input by the user at any nuclear facility. A database structure is built and BORLAND DELPHI programming language has been used. The software is designed to be user-friendly, to make extensive and flexible management of menus and graphs. SARS functions include basic physical inventory tacking, transaction histories and reporting. Access controls are made by different passwords.

  2. Effects of Long-Haul Transmeridian Travel on Subjective Jet-Lag and Self-Reported Sleep and Upper Respiratory Symptoms in Professional Rugby League Players.

    PubMed

    Fowler, Peter M; Duffield, Rob; Lu, Donna; Hickmans, Jeremy A; Scott, Tannath J

    2016-10-01

    To examine the effects of 24-h travel west across 11 time zones on subjective jet-lag and wellness responses together with self-reported sleep and upper respiratory symptoms in 18 professional rugby league players. Measures were obtained 1 or 2 d before (pretravel) and 2, 6, and 8 d after travel (post-2, post-6, and post-8) from Australia to the United Kingdom (UK) for the 2015 World Club Series. Compared with pretravel, subjective jet-lag remained significantly elevated on post-8 (3.1 ± 2.3, P < .05, d > 0.90), although it was greatest on post-2 (4.1 ± 1.4). Self-reported sleep-onset times were significantly earlier on post-2 than at all other time points (P < .05, d > 0.90), and large effect sizes suggested that wake times were earlier on post-2 than on post-6 and post-8 (d > 0.90). Although significantly more upper respiratory symptoms were reported on post-6 than at pretravel (P < .05, d ˃ 0.90), no incidence of injury and negligible changes in wellness and muscle strength and range of motion (P > .05, d < 0.90) were evident after travel. Results suggest that westward long-haul travel between Australia and the UK exacerbates subjective jet-lag and sleep responses, along with upper respiratory symptoms, in professional rugby league players. Of note, the increase in self-reported upper respiratory symptoms is a reminder that the demands of long-haul travel may be an additional concern in jet-lag for traveling athletes. However, due to the lack of sport-specific performance measures, it is still unclear whether international travel interferes with training to the extent that subsequent competition performance is impaired.

  3. The Weighted-Average Lagged Ensemble.

    PubMed

    DelSole, T; Trenary, L; Tippett, M K

    2017-11-01

    A lagged ensemble is an ensemble of forecasts from the same model initialized at different times but verifying at the same time. The skill of a lagged ensemble mean can be improved by assigning weights to different forecasts in such a way as to maximize skill. If the forecasts are bias corrected, then an unbiased weighted lagged ensemble requires the weights to sum to one. Such a scheme is called a weighted-average lagged ensemble. In the limit of uncorrelated errors, the optimal weights are positive and decay monotonically with lead time, so that the least skillful forecasts have the least weight. In more realistic applications, the optimal weights do not always behave this way. This paper presents a series of analytic examples designed to illuminate conditions under which the weights of an optimal weighted-average lagged ensemble become negative or depend nonmonotonically on lead time. It is shown that negative weights are most likely to occur when the errors grow rapidly and are highly correlated across lead time. The weights are most likely to behave nonmonotonically when the mean square error is approximately constant over the range forecasts included in the lagged ensemble. An extreme example of the latter behavior is presented in which the optimal weights vanish everywhere except at the shortest and longest lead times.

  4. 47 CFR 52.103 - Lag times.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

  5. 47 CFR 52.103 - Lag times.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

  6. 47 CFR 52.103 - Lag times.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

  7. 47 CFR 52.103 - Lag times.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

  8. Shear Lag in Box Beams Methods of Analysis and Experimental Investigations

    NASA Technical Reports Server (NTRS)

    Kuhn, Paul; Chiarito, Patrick T

    1942-01-01

    The bending stresses in the covers of box beams or wide-flange beams differ appreciably from the stresses predicted by the ordinary bending theory on account of shear deformation of the flanges. The problem of predicting these differences has become known as the shear-lag problem. The first part of this paper deals with methods of shear-lag analysis suitable for practical use. The second part of the paper describes strain-gage tests made by the NACA to verify the theory. Three tests published by other investigators are also analyzed by the proposed method. The third part of the paper gives numerical examples illustrating the methods of analysis. An appendix gives comparisons with other methods, particularly with the method of Ebner and Koller.

  9. Fungal mycelia show lag time before re-growth on endogenous carbon.

    PubMed

    Pollack, Judith K; Li, Zheng Jian; Marten, Mark R

    2008-06-15

    Nutrient starvation is a common occurrence for filamentous fungi. To better understand the effects of starvation, we used a parallel plate flow chamber to study individual fungal mycelia when subjected to a step change in glucose concentration. We report the presence of a finite "lag time" in starved mycelia during which they ceased to grow/extend while switching from growth on exogenous carbon to re-growth on endogenous carbon. This lag time precedes other morphological or physiological changes such as change in growth rate (50-70% reduction), vacuolation (up to 16%), and decreased hyphal diameter (almost 50% reduction). Data suggests that during lag time, vacuolar degradation produces sufficient endogenous carbon to support survival and restart hyphal extension. Lag time is inversely related to the size of the mycelium at the time of starvation, which suggests a critical flow of endogenous carbon to the apical tip. We present a mathematical model consistent with our experimental observations that relate lag time, area, and flow of endogenous carbon. (c) 2008 Wiley Periodicals, Inc.

  10. What time-lag for a retraction search on PubMed?

    PubMed

    Decullier, Evelyne; Huot, Laure; Maisonneuve, Hervé

    2014-06-25

    To investigate fraud and errors, scientists have studied cohorts of retraction notices. These researches have been performed using a PubMed search on publication type "retraction of publication" which retrieves the notices of the retractions. We assessed the stability of the indexation of retraction notices over a 15-month period and what was the time-lag to get stability. A search on notices of retraction issued in 2008 was repeated every 3 months during 15 months from February 2011. The first search resulted in 237 notices of retraction. Throughout the study period, 14 discrepancies with the initial search were observed (6%). We found that the number of retraction notices became stable 35 months after the retraction. The time-lag observed in this study has to be taken into account when performing a PubMed search.

  11. Estimation of watershed lag times and times of concentration for the Kansas City Area.

    DOT National Transportation Integrated Search

    2016-04-01

    Lag time (TL) and time of concentration (TC) are two related measures of how quickly a stream responds to : runoff-producing rainfall over its watershed. In this report, a general relationship for lag time is derived from the : Manning equation for f...

  12. Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance.

    PubMed

    D'Elia, Riccardo; Allen, Patricia L; Johanson, Kelly; Nickerson, Cheryl A; Hammond, Timothy G

    2005-06-01

    This study identifies genes that determine length of lag phase, using the model eukaryotic organism, Saccharomyces cerevisiae. We report growth of a yeast deletion series following variations in the lag phase induced by variable storage times after drying-down yeast on filters. Using a homozygous diploid deletion pool, lag times ranging from 0 h to 90 h were associated with increased drop-out of mitochondrial genes and increased survival of nuclear genes. Simple linear regression (R2 analysis) shows that there are over 500 genes for which > 70% of the variation can be explained by lag alone. In the genes with a positive correlation, such that the gene abundance increases with lag and hence the deletion strain is suitable for survival during prolonged storage, there is a strong predominance of nucleonic genes. In the genes with a negative correlation, such that the gene abundance decreases with lag and hence the strain may be critical for getting yeast out of the lag phase, there is a strong predominance of glycoproteins and transmembrane proteins. This study identifies yeast deletion strains with survival advantage on prolonged storage and amplifies our understanding of the genes critical for getting out of the lag phase.

  13. Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance

    NASA Technical Reports Server (NTRS)

    D'Elia, Riccardo; Allen, Patricia L.; Johanson, Kelly; Nickerson, Cheryl A.; Hammond, Timothy G.

    2005-01-01

    This study identifies genes that determine length of lag phase, using the model eukaryotic organism, Saccharomyces cerevisiae. We report growth of a yeast deletion series following variations in the lag phase induced by variable storage times after drying-down yeast on filters. Using a homozygous diploid deletion pool, lag times ranging from 0 h to 90 h were associated with increased drop-out of mitochondrial genes and increased survival of nuclear genes. Simple linear regression (R2 analysis) shows that there are over 500 genes for which > 70% of the variation can be explained by lag alone. In the genes with a positive correlation, such that the gene abundance increases with lag and hence the deletion strain is suitable for survival during prolonged storage, there is a strong predominance of nucleonic genes. In the genes with a negative correlation, such that the gene abundance decreases with lag and hence the strain may be critical for getting yeast out of the lag phase, there is a strong predominance of glycoproteins and transmembrane proteins. This study identifies yeast deletion strains with survival advantage on prolonged storage and amplifies our understanding of the genes critical for getting out of the lag phase.

  14. Robust Short-Lag Spatial Coherence Imaging.

    PubMed

    Nair, Arun Asokan; Tran, Trac Duy; Bell, Muyinatu A Lediju

    2018-03-01

    Short-lag spatial coherence (SLSC) imaging displays the spatial coherence between backscattered ultrasound echoes instead of their signal amplitudes and is more robust to noise and clutter artifacts when compared with traditional delay-and-sum (DAS) B-mode imaging. However, SLSC imaging does not consider the content of images formed with different lags, and thus does not exploit the differences in tissue texture at each short-lag value. Our proposed method improves SLSC imaging by weighting the addition of lag values (i.e., M-weighting) and by applying robust principal component analysis (RPCA) to search for a low-dimensional subspace for projecting coherence images created with different lag values. The RPCA-based projections are considered to be denoised versions of the originals that are then weighted and added across lags to yield a final robust SLSC (R-SLSC) image. Our approach was tested on simulation, phantom, and in vivo liver data. Relative to DAS B-mode images, the mean contrast, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) improvements with R-SLSC images are 21.22 dB, 2.54, and 2.36, respectively, when averaged over simulated, phantom, and in vivo data and over all lags considered, which corresponds to mean improvements of 96.4%, 121.2%, and 120.5%, respectively. When compared with SLSC images, the corresponding mean improvements with R-SLSC images were 7.38 dB, 1.52, and 1.30, respectively (i.e., mean improvements of 14.5%, 50.5%, and 43.2%, respectively). Results show great promise for smoothing out the tissue texture of SLSC images and enhancing anechoic or hypoechoic target visibility at higher lag values, which could be useful in clinical tasks such as breast cyst visualization, liver vessel tracking, and obese patient imaging.

  15. Stabilized NADH as a Countermeasure for Jet Lag

    NASA Technical Reports Server (NTRS)

    Kay, Gary G.; Viirre, Erik; Clark, Jonathan

    2001-01-01

    Current remedies for jet lag (phototherapy, melatonin, stimulant, and sedative medications) are limited in efficacy and practicality. The efficacy of a stabilized, sublingual form of reduced nicotin amide adenine dinucleotide (NADH, ENADAlert, Menuco Corp.) as a countermeasure for jet lag was examined. Because NADH increases cellular production of ATP and facilitates dopamine synthesis, it may counteract the effects of jet lag on cognitive functioning and sleepiness. Thirty-five healthy, employed subjects participated in this double-blind, placebo-controlled study. Training and baseline testing were conducted on the West Coast before subjects flew overnight to the East Coast, where they would experience a 3-hour time difference. Upon arrival, individuals were randomly assigned to receive either 20 mg of sublingual stabilized ADH (n=18) or identical placebo tablets (n=17). All participants completed computer-administered tests (including CogScreen7) to assess changes in cognitive functioning, mood, and sleepiness in the morning and afternoon. Jet lag resulted in increased sleepiness for over half the participants and deterioration of cognitive functioning for approximately one third. The morning following the flight, subjects experienced lapses of attention in addition to disruptions in working memory, divided attention, and visual perceptual speed. Individuals who received NADH performed significantly better on 5 of 8 cognitive and psychomotor test measures (P less than or equal to 0.5) and showed a trend for better performance on the other three measures (P less than or equal to .l0). Subjects also reported less sleepiness compared with those who received placebo. No adverse effects were observed with NADH treatment. Stabilized NADH significantly reduced jet lag-induced disruptions of cognitive functioning, was easily administered, and was found to have no adverse side effects.

  16. Melatonin for preventing and treating jet lag.

    PubMed

    Herxheimer, A; Petrie, K J

    2001-01-01

    Jet-lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world. To assess the effectiveness of oral melatonin taken in different dosage regimens for alleviating jet-lag after air travel across several time zones. We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE, PsychLit and Science Citation Index electronically, and the journals 'Aviation, Space and Environmental Medicine' and 'Sleep' by hand. We searched citation lists of relevant studies for other relevant trials. We asked principal authors of relevant studies to tell us about unpublished trials. Reports of adverse events linked to melatonin use outside randomised trials were searched for systematically in 'Side Effects of Drugs' (SED) and SED Annuals, 'Reactions Weekly', MEDLINE, and the adverse drug reactions databases of the WHO Uppsala Monitoring Centre (UMC) and the US Food & Drug Administration. Randomised trials in airline passengers, airline staff or military personnel given oral melatonin, compared with placebo or other medication. Outcome measures should consist of subjective rating of jet-lag or related components, such as subjective wellbeing, daytime tiredness, onset and quality of sleep, psychological functioning, duration of return to normal, or indicators of circadian rhythms. : Ten trials met the inclusion criteria. All compared melatonin with placebo; one in addition compared it with a hypnotic, zolpidem. Nine of the trials were of adequate quality to contribute to the assessment, one had a design fault and could not be used in the assessment. Reports of adverse events outside trials were found through MEDLINE, 'Reactions Weekly', and in the WHO UMC database. : Nine of the ten trials found that melatonin, taken

  17. 77 FR 43967 - Account Ownership and Control Report; Withdrawal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... 15, 16, 17, et al. Account Ownership and Control Report; Withdrawal; Ownership and Control Reports... RIN 3038-AC63 Account Ownership and Control Report; Withdrawal AGENCY: Commodity Futures Trading... ownership and control information for all trading accounts active on U.S. futures exchanges and other...

  18. A nonlinear lag correction algorithm for a-Si flat-panel x-ray detectors

    PubMed Central

    Starman, Jared; Star-Lack, Josh; Virshup, Gary; Shapiro, Edward; Fahrig, Rebecca

    2012-01-01

    Purpose: Detector lag, or residual signal, in a-Si flat-panel (FP) detectors can cause significant shading artifacts in cone-beam computed tomography reconstructions. To date, most correction models have assumed a linear, time-invariant (LTI) model and correct lag by deconvolution with an impulse response function (IRF). However, the lag correction is sensitive to both the exposure intensity and the technique used for determining the IRF. Even when the LTI correction that produces the minimum error is found, residual artifact remains. A new non-LTI method was developed to take into account the IRF measurement technique and exposure dependencies. Methods: First, a multiexponential (N = 4) LTI model was implemented for lag correction. Next, a non-LTI lag correction, known as the nonlinear consistent stored charge (NLCSC) method, was developed based on the LTI multiexponential method. It differs from other nonlinear lag correction algorithms in that it maintains a consistent estimate of the amount of charge stored in the FP and it does not require intimate knowledge of the semiconductor parameters specific to the FP. For the NLCSC method, all coefficients of the IRF are functions of exposure intensity. Another nonlinear lag correction method that only used an intensity weighting of the IRF was also compared. The correction algorithms were applied to step-response projection data and CT acquisitions of a large pelvic phantom and an acrylic head phantom. The authors collected rising and falling edge step-response data on a Varian 4030CB a-Si FP detector operating in dynamic gain mode at 15 fps at nine incident exposures (2.0%–92% of the detector saturation exposure). For projection data, 1st and 50th frame lag were measured before and after correction. For the CT reconstructions, five pairs of ROIs were defined and the maximum and mean signal differences within a pair were calculated for the different exposures and step-response edge techniques. Results: The LTI

  19. State Technical Committee for Accounting. Official Report.

    ERIC Educational Resources Information Center

    Jensen, Claudia

    This report contains validated task inventory listings for accounting occupations. An introductory report in brief outline form gives background of the work of the technical committee that identified the duties and tasks. This is followed by four attachments which make up most of the document. Attachment A has two parts: (1) an accounting skills…

  20. Repetition and lag effects in movement recognition.

    PubMed

    Hall, C R; Buckolz, E

    1982-03-01

    Whether repetition and lag improve the recognition of movement patterns was investigated. Recognition memory was tested for one repetition, two-repetitions massed, and two-repetitions distributed with movement patterns at lags of 3, 5, 7, and 13. Recognition performance was examined both immediately afterwards and following a 48 hour delay. Both repetition and lag effects failed to be demonstrated, providing some support for the claim that memory is unaffected by repetition at a constant level of processing (Craik & Lockhart, 1972). There was, as expected, a significant decrease in recognition memory following the retention interval, but this appeared unrelated to repetition or lag.

  1. 15 CFR 400.46 - Accounts, records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Director. (d) Annual reports. (1) Zone grantees shall submit annual reports to the Board at the time and in...) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF COMMERCE REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Zone Operations and Administrative Requirements § 400.46 Accounts, records and reports. (a) Zone accounts. Zone...

  2. Assessing the dream-lag effect for REM and NREM stage 2 dreams.

    PubMed

    Blagrove, Mark; Fouquet, Nathalie C; Henley-Einion, Josephine A; Pace-Schott, Edward F; Davies, Anna C; Neuschaffer, Jennifer L; Turnbull, Oliver H

    2011-01-01

    This study investigates evidence, from dream reports, for memory consolidation during sleep. It is well-known that events and memories from waking life can be incorporated into dreams. These incorporations can be a literal replication of what occurred in waking life, or, more often, they can be partial or indirect. Two types of temporal relationship have been found to characterize the time of occurrence of a daytime event and the reappearance or incorporation of its features in a dream. These temporal relationships are referred to as the day-residue or immediate incorporation effect, where there is the reappearance of features from events occurring on the immediately preceding day, and the dream-lag effect, where there is the reappearance of features from events occurring 5-7 days prior to the dream. Previous work on the dream-lag effect has used spontaneous home recalled dream reports, which can be from Rapid Eye Movement Sleep (REM) and from non-Rapid Eye Movement Sleep (NREM). This study addresses whether the dream-lag effect occurs only for REM sleep dreams, or for both REM and NREM stage 2 (N2) dreams. 20 participants kept a daily diary for over a week before sleeping in the sleep laboratory for 2 nights. REM and N2 dreams collected in the laboratory were transcribed and each participant rated the level of correspondence between every dream report and every diary record. The dream-lag effect was found for REM but not N2 dreams. Further analysis indicated that this result was not due to N2 dream reports being shorter, in terms of number of words, than the REM dream reports. These results provide evidence for a 7-day sleep-dependent non-linear memory consolidation process that is specific to REM sleep, and accord with proposals for the importance of REM sleep to emotional memory consolidation.

  3. Assessing the Dream-Lag Effect for REM and NREM Stage 2 Dreams

    PubMed Central

    Blagrove, Mark; Fouquet, Nathalie C.; Henley-Einion, Josephine A.; Pace-Schott, Edward F.; Davies, Anna C.; Neuschaffer, Jennifer L.; Turnbull, Oliver H.

    2011-01-01

    This study investigates evidence, from dream reports, for memory consolidation during sleep. It is well-known that events and memories from waking life can be incorporated into dreams. These incorporations can be a literal replication of what occurred in waking life, or, more often, they can be partial or indirect. Two types of temporal relationship have been found to characterize the time of occurrence of a daytime event and the reappearance or incorporation of its features in a dream. These temporal relationships are referred to as the day-residue or immediate incorporation effect, where there is the reappearance of features from events occurring on the immediately preceding day, and the dream-lag effect, where there is the reappearance of features from events occurring 5–7 days prior to the dream. Previous work on the dream-lag effect has used spontaneous home recalled dream reports, which can be from Rapid Eye Movement Sleep (REM) and from non-Rapid Eye Movement Sleep (NREM). This study addresses whether the dream-lag effect occurs only for REM sleep dreams, or for both REM and NREM stage 2 (N2) dreams. 20 participants kept a daily diary for over a week before sleeping in the sleep laboratory for 2 nights. REM and N2 dreams collected in the laboratory were transcribed and each participant rated the level of correspondence between every dream report and every diary record. The dream-lag effect was found for REM but not N2 dreams. Further analysis indicated that this result was not due to N2 dream reports being shorter, in terms of number of words, than the REM dream reports. These results provide evidence for a 7-day sleep-dependent non-linear memory consolidation process that is specific to REM sleep, and accord with proposals for the importance of REM sleep to emotional memory consolidation. PMID:22046336

  4. State-dependent resource harvesting with lagged information about system states

    USGS Publications Warehouse

    Johnson, Fred A.; Fackler, Paul L.; Boomer, G Scott; Zimmerman, Guthrie S.; Williams, Byron K.; Nichols, James D.; Dorazio, Robert

    2016-01-01

    Markov decision processes (MDPs), which involve a temporal sequence of actions conditioned on the state of the managed system, are increasingly being applied in natural resource management. This study focuses on the modification of a traditional MDP to account for those cases in which an action must be chosen after a significant time lag in observing system state, but just prior to a new observation. In order to calculate an optimal decision policy under these conditions, possible actions must be conditioned on the previous observed system state and action taken. We show how to solve these problems when the state transition structure is known and when it is uncertain. Our focus is on the latter case, and we show how actions must be conditioned not only on the previous system state and action, but on the probabilities associated with alternative models of system dynamics. To demonstrate this framework, we calculated and simulated optimal, adaptive policies for MDPs with lagged states for the problem of deciding annual harvest regulations for mallards (Anas platyrhynchos) in the United States. In this particular example, changes in harvest policy induced by the use of lagged information about system state were sufficient to maintain expected management performance (e.g. population size, harvest) even in the face of an uncertain system state at the time of a decision.

  5. Spectral lags in different episodes of gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Jia, LanWei; Yi, TingFeng; Liang, EnWei

    2013-08-01

    A systematical analysis of the spectral lags in different episodes within a gamma-ray burst (GRB) for the BATSE GRB sample is given. The identified episodes are usually a single pulse with mixing of small fluctuations. The spectral lags were calculated for lightcurves in the 25-55 keV and 110-320 keV bands. No universal spectral lag evolution feature in different episodes within a GRB were found for most GRBs. Among 362 bright GRBs that have at least three well-identified episodes, 19 of them show long-to-short lag and 19 of them show short-to-long lag in successive episodes. The other 324 GRBs have no clear evolution trend. Defining the specified lag with the ratio of the spectral lag to the episode duration in 110-320 keV band, no prominent case of specified lag was found showing clear evolution features. The results suggest that the observed spectral lag may contribute to the dynamics and/or the radiation physics of a given emission episode.

  6. Long-Lag, Wide-pulse Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Norris, J. P.; Bonnell, J. T.; Kazanas, D.; Scargle, . D.; Hakkila, J.; Giblin, T. W.

    2004-01-01

    Currently, the best available probe of the early phase of gamma-ray burst (GRB) jet attributes is the prompt gamma-ray emission, in which several intrinsic and extrinsic variables determine GRB pulse evolution. Bright, usually complex bursts have many narrow pulses that are difficult to model due to overlap. However, the relatively simple, long spectral lag, wide-pulse bursts may have simpler physics and are easier to model. In this work we analyze the temporal and spectral behavior of wide pulses in 24 long-lag bursts, using a pulse model with two shape parameters - width and asymmetry - and the Band spectral model with three shape parameters. We find that pulses in long-lag bursts are distinguished both temporally and spectrally from those in bright bursts: the pulses in long spectral lag bursts are few in number, and approximately 100 times wider (10s of seconds), have systematically lower peaks in vF(v), harder low-energy spectra and softer high-energy spectra. We find that these five pulse descriptors are essentially uncorrelated for our long-lag sample, suggesting that at least approximately 5 parameters are needed to model burst temporal and spectral behavior. However, pulse width is strongly correlated with spectral lag; hence these two parameters may be viewed as mutual surrogates. We infer that accurate formulations for estimating GRB luminosity and total energy will depend on several gamma-ray attributes, at least for long-lag bursts. The prevalence of long-lag bursts near the BATSE trigger threshold, their predominantly low vF(v) spectral peaks, and relatively steep upper power-law spectral indices indicate that Swift will detect many such bursts.

  7. NASA FY 2000 Accountability Report

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This Accountability Report consolidates reports required by various statutes and summarizes NASA's program accomplishments and its stewardship over budget and financial resources. It is a culmination of NASA's management process, which begins with mission definition and program planning, continues with the formulation and justification of budgets for the President and Congress, and ends with scientific and engineering program accomplishments. The report covers activities from October 1, 1999, through September 30, 2000. Achievements are highlighted in the Statement of the Administrator and summarized in the Report.

  8. Four-Year Cross-Lagged Associations between Physical and Mental Health in the Medical Outcomes Study.

    ERIC Educational Resources Information Center

    Hays, Ron D.; And Others

    1994-01-01

    Applied structural equation modeling to evaluation of cross-lagged panel models. Self-reports of physical and mental health at three time points spanning four-year interval were analyzed to illustrate cross-lagged analysis methodology. Data were analyzed from 856 patients with hypertension, diabetes, heart disease, or depression. Cross-lagged…

  9. 46 CFR 36.30-1 - Lagged tanks-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

  10. 46 CFR 36.30-1 - Lagged tanks-TB/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

  11. 46 CFR 36.30-1 - Lagged tanks-TB/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

  12. 46 CFR 36.30-1 - Lagged tanks-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

  13. 46 CFR 36.30-1 - Lagged tanks-TB/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

  14. Analysis of Quasi-periodic Oscillations and Time Lag in Ultraluminous X-Ray Sources with XMM-Newton

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Zi-Jian; Xiao, Guang-Cheng; Zhang, Shu

    We investigated the power density spectrum (PDS) and time lag of ultraluminous X-ray sources (ULXs) observed by XMM-Newton . We determined the PDSs for each ULX and found that five of them show intrinsic variability due to obvious quasi-periodic oscillations (QPOs) of mHz–1 Hz, consistent with previous reports. We further investigated these five ULXs to determine their possible time lag. The ULX QPOs exhibit a soft time lag that is linearly related to the QPO frequency. We discuss the likelihood of the ULX QPOs being type-C QPO analogs, and the time lag models. The ULXs might harbor intermediate-mass black holesmore » if their QPOs are type-C QPO analogs. We suggest that the soft lag and the linearity may be due to reverberation.« less

  15. Comparing lagged linear correlation, lagged regression, Granger causality, and vector autoregression for uncovering associations in EHR data.

    PubMed

    Levine, Matthew E; Albers, David J; Hripcsak, George

    2016-01-01

    Time series analysis methods have been shown to reveal clinical and biological associations in data collected in the electronic health record. We wish to develop reliable high-throughput methods for identifying adverse drug effects that are easy to implement and produce readily interpretable results. To move toward this goal, we used univariate and multivariate lagged regression models to investigate associations between twenty pairs of drug orders and laboratory measurements. Multivariate lagged regression models exhibited higher sensitivity and specificity than univariate lagged regression in the 20 examples, and incorporating autoregressive terms for labs and drugs produced more robust signals in cases of known associations among the 20 example pairings. Moreover, including inpatient admission terms in the model attenuated the signals for some cases of unlikely associations, demonstrating how multivariate lagged regression models' explicit handling of context-based variables can provide a simple way to probe for health-care processes that confound analyses of EHR data.

  16. The effects of preceding lead-alone and lag-alone click trains on the buildup of echo suppression.

    PubMed

    Bishop, Christopher W; Yadav, Deepak; London, Sam; Miller, Lee M

    2014-08-01

    Spatial perception in echoic environments is influenced by recent acoustic history. For instance, echo suppression becomes more effective or "builds up" with repeated exposure to echoes having a consistent acoustic relationship to a temporally leading sound. Four experiments were conducted to investigate how buildup is affected by prior exposure to unpaired lead-alone or lag-alone click trains. Unpaired trains preceded lead-lag click trains designed to evoke and assay buildup. Listeners reported how many sounds they heard from the echo hemifield during the lead-lag trains. Stimuli were presented in free field (experiments 1 and 4) or dichotically through earphones (experiments 2 and 3). In experiment 1, listeners reported more echoes following a lead-alone train compared to a period of silence. In contrast, listeners reported fewer echoes following a lag-alone train; similar results were observed with earphones. Interestingly, the effects of lag-alone click trains on buildup were qualitatively different when compared to a no-conditioner trial type in experiment 4. Finally, experiment 3 demonstrated that the effects of preceding click trains on buildup cannot be explained by a change in counting strategy or perceived click salience. Together, these findings demonstrate that echo suppression is affected by prior exposure to unpaired stimuli.

  17. 2014-15 System Accountability Report. Appendix: Data Tables

    ERIC Educational Resources Information Center

    Board of Governors, State University System of Florida, 2016

    2016-01-01

    This system accountability report provides the Data Tables that are appended to the 2014-2015 accountability report. The data tables include detailed statistical information presented in a tabular format on the following subject matter: (1) Financial Resources; (2) Personnel; (3) Enrollment; (4) Undergraduate Education; (5) Graduate Education; and…

  18. A New Measurement of the Spectral Lag of Gamma-Ray Bursts and its Implications for Spectral Evolution Behaviors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shao, Lang; Wang, Fu-Ri; Cheng, Ye-Hao

    We carry out a systematical study of the spectral lag properties of 50 single-pulsed gamma-ray bursts (GRBs) detected by the Fermi Gamma-Ray Burst Monitor. By dividing the light curves into multiple consecutive energy channels, we provide a new measurement of the spectral lag that is independent of energy channel selections. We perform a detailed statistical study of our new measurements. We find two similar power-law energy dependencies of both the pulse arrival time and pulse width. Our new results on the power-law indices would favor the relativistic geometric effects for the origin of spectral lag. However, a complete theoretical frameworkmore » that can fully account for the diverse energy dependencies of both arrival time and pulse width revealed in this work is still lacking. We also study the spectral evolution behaviors of the GRB pulses. We find that a GRB pulse with negligible spectral lag would usually have a shorter pulse duration and would appear to have a “hardness-intensity tracking” behavior, and a GRB pulse with a significant spectral lag would usually have a longer pulse duration and would appear to have a “hard-to-soft” behavior.« less

  19. A Management Reporting Manual for Colleges: A System of Reporting and Accounting.

    ERIC Educational Resources Information Center

    Hughes, K. Scott; And Others

    This manual, a revision of the 1976 publication entitled "Management Reports," is intended to assist college business officers in establishing sound accounting systems and in preparing readable and meaningful financial management reports. A detailed description of the accounting system and a new expenditure classification structure have been…

  20. Diverse Responses of Global Vegetation to Climate Changes: Spatial Patterns and Time-lag Effects

    NASA Astrophysics Data System (ADS)

    Wu, D.; Zhao, X.; Zhou, T.; Huang, K.; Xu, W.

    2014-12-01

    Global climate changes have enormous influences on vegetation growth, meanwhile, response of vegetation to climate express space diversity and time-lag effects, which account for spatial-temporal disparities of climate change and spatial heterogeneity of ecosystem. Revelation of this phenomenon will help us further understanding the impact of climate change on vegetation. Assessment and forecast of global environmental change can be also improved under further climate change. Here we present space diversity and time-lag effects patterns of global vegetation respond to three climate factors (temperature, precipitation and solar radiation) based on quantitative analysis of satellite data (NDVI) and Climate data (Climate Research Unit). We assessed the time-lag effects of global vegetation to main climate factors based on the great correlation fitness between NDVI and the three climate factors respectively among 0-12 months' temporal lags. On this basis, integrated response model of NDVI and the three climate factors was built to analyze contribution of different climate factors to vegetation growth with multiple regression model and partial correlation model. In the result, different vegetation types have distinct temporal lags to the three climate factors. For the precipitation, temporal lags of grasslands are the shortest while the evergreen broad-leaf forests are the longest, which means that grasslands are more sensitive to precipitation than evergreen broad-leaf forests. Analysis of different climate factors' contribution to vegetation reveal that vegetation are dominated by temperature in the high northern latitudes; they are mainly restricted by precipitation in arid and semi-arid areas (Australia, Western America); in humid areas of low and intermediate latitudes (Amazon, Eastern America), vegetation are mainly influenced by solar radiation. Our results reveal the time-lag effects and major driving factors of global vegetation growth and explain the

  1. 17 CFR 210.2-02 - Accountants' reports and attestation reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... respect of the financial statements covered by the report and the accounting principles and practices... accounting principles, or as to any changes in such principles which have a material effect on the financial... COMMISSION FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES ACT OF 1933, SECURITIES...

  2. NASA Accountability Report

    NASA Technical Reports Server (NTRS)

    1997-01-01

    NASA is piloting fiscal year (FY) 1997 Accountability Reports, which streamline and upgrade reporting to Congress and the public. The document presents statements by the NASA administrator, and the Chief Financial Officer, followed by an overview of NASA's organizational structure and the planning and budgeting process. The performance of NASA in four strategic enterprises is reviewed: (1) Space Science, (2) Mission to Planet Earth, (3) Human Exploration and Development of Space, and (4) Aeronautics and Space Transportation Technology. Those areas which support the strategic enterprises are also reviewed in a section called Crosscutting Processes. For each of the four enterprises, there is discussion about the long term goals, the short term objectives and the accomplishments during FY 1997. The Crosscutting Processes section reviews issues and accomplishments relating to human resources, procurement, information technology, physical resources, financial management, small and disadvantaged businesses, and policy and plans. Following the discussion about the individual areas is Management's Discussion and Analysis, about NASA's financial statements. This is followed by a report by an independent commercial auditor and the financial statements.

  3. LAG3 Expression in Active Mycobacterium tuberculosis Infections

    PubMed Central

    Phillips, Bonnie L.; Mehra, Smriti; Ahsan, Muhammad H.; Selman, Moises; Khader, Shabaana A.; Kaushal, Deepak

    2016-01-01

    Mycobacterium tuberculosis (MTB) is a highly successful pathogen because of its ability to persist in human lungs for long periods of time. MTB modulates several aspects of the host immune response. Lymphocyte-activation gene 3 (LAG3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cells with immunomodulatory functions. To understand the function of LAG3 during MTB infection, a nonhuman primate model of tuberculosis, which recapitulates key aspects of natural human infection in rhesus macaques (Macaca mulatta), was used. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with MTB. Furthermore, we show that LAG3 expression is not induced in the lungs and lung granulomas of animals exhibiting latent tuberculosis infection. However, simian immunodeficiency virus–induced reactivation of latent tuberculosis infection results in an increased expression of LAG3 in the lungs. This response is not observed in nonhuman primates infected with non-MTB bacterial pathogens, nor with simian immunodeficiency virus alone. Our data show that LAG3 was expressed primarily on CD4+ T cells, presumably by regulatory T cells but also by natural killer cells. The expression of LAG3 coincides with high bacterial burdens and changes in the host type 1 helper T-cell response. PMID:25549835

  4. Accounts receivable reports: underutilized mining tools.

    PubMed

    Wallace, R

    1999-01-01

    There is gold to be found in accounts receivable reports for those willing to mine the data. The key is to know how to interpret the information buried within the numbers and use it to recover monies owed. This article identifies seven reports that should be staples in every organization committed to improving its overall collection performance. Also included are tips on understanding reports and implementing changes.

  5. Long-Lag, Wide-pulse Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Norris, J. P.; Bonnell, J. T.; Kazanas, D.; Scargie, J. D.; Hakkila, J.; Giblin, T. W.

    2005-01-01

    The best available probe of the early phase of gamma-ray burst (GRB) jet attributes is the prompt gamma-ray emission, in which several intrinsic and extrinsic variables determine observed GRB pulse evolution, including at least: jet opening angle, profiles of Lorentz factor and matter/field density, distance of emission region from central source, and viewing angle. Bright, usually complex bursts have many narrow pulses that are difficult to model due to overlap. However, the relatively simple, long spectral lag, wide-pulse bursts may have simpler physics and are easier to model. We have analyzed the temporal and spectral behavior of wide pulses in 24 long-lag bursts from the BATSE sample, using a pulse model with two shape parameters - width and asymmetry - and the Band spectral model with three shape parameters. We find that pulses in long-lag bursts are distinguished both temporally and spectrally from those in bright bursts: the pulses in long spectral lag bursts are few in number, and approximately 100 times wider (10s of seconds), have systemtically lower peaks in nu*F(nu), harder low-energy spectra and softer high-energy spectra. These five pulse descriptors are essentially uncorrelated for our long-lag sample, suggesting that at least approximately 5 parameters are needed to model burst temporal and spectral behavior, roughly commensurate with the theoretical phase space. However, we do find that pulse width is strongly correlated with spectral lag; hence these two parameters may be viewed as mutual surrogates. The prevalence of long-lag bursts near the BATSE trigger threshold, their predominantly low nu*F(nu) spectral peaks, and relatively steep upper power-law spectral indices indicate that Swiift will detect many such bursts.

  6. Behavioral Processes in Long-Lag Intervention Studies.

    PubMed

    Miller, Dale T; Dannals, Jennifer E; Zlatev, Julian J

    2017-05-01

    We argue that psychologists who conduct experiments with long lags between the manipulation and the outcome measure should pay more attention to behavioral processes that intervene between the manipulation and the outcome measure. Neglect of such processes, we contend, stems from psychology's long tradition of short-lag lab experiments where there is little scope for intervening behavioral processes. Studying process in the lab invariably involves studying psychological processes, but in long-lag field experiments it is important to study causally relevant behavioral processes as well as psychological ones. To illustrate the roles that behavioral processes can play in long-lag experiments we examine field experiments motivated by three policy-relevant goals: prejudice reduction, health promotion, and educational achievement. In each of the experiments discussed we identify various behavioral pathways through which the manipulated psychological state could have produced the observed outcome. We argue that if psychologists conducting long-lag interventions posited a theory of change that linked manipulated psychological states to outcomes via behavioral pathways, the result would be richer theory and more practically useful research. Movement in this direction would also permit more opportunities for productive collaborations between psychologists and other social scientists interested in similar social problems.

  7. X-ray time lags in PG 1211+143

    NASA Astrophysics Data System (ADS)

    Lobban, A. P.; Vaughan, S.; Pounds, K.; Reeves, J. N.

    2018-05-01

    We investigate the X-ray time lags of a recent ˜630 ks XMM-Newton observation of PG 1211+143. We find well-correlated variations across the XMM-Newton EPIC bandpass, with the first detection of a hard lag in this source with a mean time delay of up to ˜3 ks at the lowest frequencies. We find that the energy-dependence of the low-frequency hard lag scales approximately linearly with log(E) when averaged over all orbits, consistent with the propagating fluctuations model. However, we find that the low-frequency lag behaviour becomes more complex on time-scales longer than a single orbit, suggestive of additional modes of variability. We also detect a high-frequency soft lag at ˜10-4 Hz with the magnitude of the delay peaking at ≲ 0.8 ks, consistent with previous observations, which we discuss in terms of small-scale reverberation.

  8. State Exemplars of School Accountability "Report Cards"

    ERIC Educational Resources Information Center

    Christie, Kathy

    2014-01-01

    This report provides profiles of exemplars of school accountability "report cards" from nine states and the District of Columbia. The exemplars were selected by Education Commission of the States (ECS) researchers and a group of 14 parents selected by ECS staff. This report contains: (1) a main "report card" page with school…

  9. LAG3 expression in active Mycobacterium tuberculosis infections.

    PubMed

    Phillips, Bonnie L; Mehra, Smriti; Ahsan, Muhammad H; Selman, Moises; Khader, Shabaana A; Kaushal, Deepak

    2015-03-01

    Mycobacterium tuberculosis (MTB) is a highly successful pathogen because of its ability to persist in human lungs for long periods of time. MTB modulates several aspects of the host immune response. Lymphocyte-activation gene 3 (LAG3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cells with immunomodulatory functions. To understand the function of LAG3 during MTB infection, a nonhuman primate model of tuberculosis, which recapitulates key aspects of natural human infection in rhesus macaques (Macaca mulatta), was used. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with MTB. Furthermore, we show that LAG3 expression is not induced in the lungs and lung granulomas of animals exhibiting latent tuberculosis infection. However, simian immunodeficiency virus-induced reactivation of latent tuberculosis infection results in an increased expression of LAG3 in the lungs. This response is not observed in nonhuman primates infected with non-MTB bacterial pathogens, nor with simian immunodeficiency virus alone. Our data show that LAG3 was expressed primarily on CD4(+) T cells, presumably by regulatory T cells but also by natural killer cells. The expression of LAG3 coincides with high bacterial burdens and changes in the host type 1 helper T-cell response. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  10. 75 FR 41775 - Account Ownership and Control Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 16 RIN 3038-AC63 Account Ownership and Control... to collect certain ownership, control, and related information for all trading accounts active on U.S.... Comments may be submitted via e-mail at [email protected] . ``Account Ownership and Control Report'' must be in...

  11. Designing More Effective Accountability Report Cards

    ERIC Educational Resources Information Center

    Sabbah, Faris M.

    2011-01-01

    The purpose of this study was to identify and design standards and procedures for creating easily interpreted accountability reports cards, consistent with the requirements spelled out in the No Child Left Behind Act of 2001 (NCLB). The use of public report cards was first raised during the debate that took place immediately prior to the passage…

  12. Lag threads organize the brain’s intrinsic activity

    PubMed Central

    Mitra, Anish; Snyder, Abraham Z.; Blazey, Tyler; Raichle, Marcus E.

    2015-01-01

    It has been widely reported that intrinsic brain activity, in a variety of animals including humans, is spatiotemporally structured. Specifically, propagated slow activity has been repeatedly demonstrated in animals. In human resting-state fMRI, spontaneous activity has been understood predominantly in terms of zero-lag temporal synchrony within widely distributed functional systems (resting-state networks). Here, we use resting-state fMRI from 1,376 normal, young adults to demonstrate that multiple, highly reproducible, temporal sequences of propagated activity, which we term “lag threads,” are present in the brain. Moreover, this propagated activity is largely unidirectional within conventionally understood resting-state networks. Modeling experiments show that resting-state networks naturally emerge as a consequence of shared patterns of propagation. An implication of these results is that common physiologic mechanisms may underlie spontaneous activity as imaged with fMRI in humans and slowly propagated activity as studied in animals. PMID:25825720

  13. Nonlinear flap-lag axial equations of a rotating beam

    NASA Technical Reports Server (NTRS)

    Kaza, K. R. V.; Kvaternik, R. G.

    1977-01-01

    It is possible to identify essentially four approaches by which analysts have established either the linear or nonlinear governing equations of motion for a particular problem related to the dynamics of rotating elastic bodies. The approaches include the effective applied load artifice in combination with a variational principle and the use of Newton's second law, written as D'Alembert's principle, applied to the deformed configuration. A third approach is a variational method in which nonlinear strain-displacement relations and a first-degree displacement field are used. The method introduced by Vigneron (1975) for deriving the linear flap-lag equations of a rotating beam constitutes the fourth approach. The reported investigation shows that all four approaches make use of the geometric nonlinear theory of elasticity. An alternative method for deriving the nonlinear coupled flap-lag-axial equations of motion is also discussed.

  14. Exposure-lag-response in Longitudinal Studies: Application of Distributed Lag Non-linear Models in an Occupational Cohort.

    PubMed

    Neophytou, Andreas M; Picciotto, Sally; Brown, Daniel M; Gallagher, Lisa E; Checkoway, Harvey; Eisen, Ellen A; Costello, Sadie

    2018-02-13

    Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed lag non-linear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and non-malignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers, followed 1942-2011. We also assessed associations using simple measures of cumulative exposure assuming linear exposure-response and constant lag-response. Measures of association from DLNMs were generally higher than from simpler models. Rate ratios from penalized DLNMs corresponding to average daily exposures of 0.4 mg/m3 during lag years 31-50 prior to the age of observed cases were 1.47 (95% confidence interval (CI) 0.92, 2.35) for lung cancer and 1.80 (95% CI: 1.14, 2.85) for non-malignant respiratory disease. Rate ratios from the simpler models for the same exposure scenario were 1.15 (95% CI: 0.89-1.48) and 1.23 (95% CI: 1.03-1.46) respectively. Longitudinal cohort studies of prolonged exposures and chronic health outcomes should explore methods allowing for flexibility and non-linearities in the exposure-lag-response. © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

  15. To lag or not to lag? How to compare indices of stock markets that operate on different times

    NASA Astrophysics Data System (ADS)

    Sandoval, Leonidas

    2014-06-01

    Financial markets worldwide do not have the same working hours. As a consequence, the study of correlation or causality between financial market indices becomes dependent on whether we should use all indices on the same day or lagged indices in computations of correlation matrices. The answer this article proposes is that we should consider both, by representing original and lagged indices in the same network. We then obtain a better understanding of how indices that operate on different hours relate to each other. We use a diverse range of 79 stock market indices from around the world and study their correlation structure, the eigenvalues and eigenvectors of their correlations under different time periods and volatility, as well as the differences between the working hours of the stock exchanges in order to analyze the possible time zone effects and suggest ways to remove them. We also analyze the enlarged correlation matrix obtained from original and lagged indices and examine a network structure derived from it, thus showing connections between lagged and original indices that could not be well represented before.

  16. Missouri Public School Accountability Report. 2009-10 School Year

    ERIC Educational Resources Information Center

    Missouri Department of Elementary and Secondary Education, 2010

    2010-01-01

    Each year, the Missouri Department of Elementary and Secondary Education publishes an online "school accountability report card" for each public school district, each building and each charter school. This document provides a statewide report card on key accountability measures about Missouri public schools, including information…

  17. Office of Inspector General report on Naval Petroleum Reserve Number 1, independent accountant`s report on applying agreed-upon procedures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-12-01

    On October 6, 1997, the Department of Energy (DOE) announced it had agreed to sell all of the Government`s interest in Naval Petroleum Reserve Number 1 (NPR-1) to Occidental Petroleum Corporation for $3.65 billion. This report presents the results of the independent certified public accountants` agreed-upon procedures work on the Preliminary Settlement Statement of the Purchase and Sale Agreement between DOE and Occidental. To fulfill their responsibilities, the Office of Inspector General contracted with the independent public accounting firm of KPMG Peat Marwick LLP to conduct the work for them, subject to their review. The work was done in accordancemore » with the Statements on Standards for Attestation Engagements issued by the American Institute of Certified Public Accountants. As such, the independent certified public accountants performed only work that was agreed upon by DOE and Occidental. This report is intended solely for the use of DOE and Occidental and should not be used by those who have not agreed to the procedures and taken responsibility for the sufficiency of the procedures for their purposes. However, this report is a matter of public record, and its distribution is not limited. The independent certified public accountants identified over 20 adjustments to the Preliminary Settlement Statement that would result in a $10.8 million increase in the sale price.« less

  18. Melatonin for the prevention and treatment of jet lag.

    PubMed

    Herxheimer, A; Petrie, K J

    2002-01-01

    : Jet-lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world. : To assess the effectiveness of oral melatonin taken in different dosage regimens for alleviating jet-lag after air travel across several time zones. : We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE, PsychLit and Science Citation Index electronically, and the journals 'Aviation, Space and Environmental Medicine' and 'Sleep' by hand. We searched citation lists of relevant studies for other relevant trials. We asked principal authors of relevant studies to tell us about unpublished trials. Reports of adverse events linked to melatonin use outside randomised trials were searched for systematically in 'Side Effects of Drugs' (SED) and SED Annuals, 'Reactions Weekly', MEDLINE, and the adverse drug reactions databases of the WHO Uppsala Monitoring Centre (UMC) and the US Food & Drug Administration. : Randomised trials in airline passengers, airline staff or military personnel given oral melatonin, compared with placebo or other medication. Outcome measures should consist of subjective rating of jet-lag or related components, such as subjective wellbeing, daytime tiredness, onset and quality of sleep, psychological functioning, duration of return to normal, or indicators of circadian rhythms. : Ten trials met the inclusion criteria. All compared melatonin with placebo; one in addition compared it with a hypnotic, zolpidem. Nine of the trials were of adequate quality to contribute to the assessment, one had a design fault and could not be used in the assessment. Reports of adverse events outside trials were found through MEDLINE, 'Reactions Weekly', and in the WHO UMC database. : Nine of the ten trials found that melatonin

  19. Applying new AICPA accounting rules on special reports.

    PubMed

    Reinstein, A; Dery, R J

    1998-04-01

    Two new standards on agreed-upon procedures, issued by the American Institute of Certified Public Accountants, provide healthcare organizations and associated decision makers with new flexibility in acquiring professional accounting services. Effective January 1, 1996, these procedures allow organizations to target the type and volume of services performed by accountants and potentially avoid the time and expense involved in completing a full financial statement audit. As with any other accounting engagement, both the healthcare organization and the accounting firm need to establish what procedures will be conducted, who will be allowed to use the resulting report, and how the procedures will be conducted.

  20. Do subjective symptoms predict our perception of jet-lag?

    PubMed

    Waterhouse, J; Edwards, B; Nevill, A; Atkinson, G; Reilly, T; Davies, P; Godfrey, R

    2000-10-01

    A total of 39 subjects were studied after a flight from the UK to either Sydney or Brisbane (10 time-zones to the east). Subjects varied widely in their age, their athletic ability, whether or not they were taking melatonin, and in their objectives when in Australia. For the first 6 days after arrival, subjects scored their jet-lag five times per day and other subjective variables up to five times per day, using visual analogue scales. For jet-lag, the scale was labelled 0 = no jet-lag to 10 = very bad jet-lag; the extremes of the other scales were labelled - 5 and + 5, indicating marked changes compared with normal, and the centrepoint was labelled 0 indicating 'normal'. Mean daily values for jet-lag and fatigue were initially high (+ 3.65 +/- 0.35 and + 1.55 +/- 0.22 on day 1, respectively) and fell progressively on subsequent days, but were still raised significantly (p < 0.05) on day 5 (fatigue) or day 6 (jet-lag). In addition, times of waking were earlier on all days. By contrast, falls in concentration and motivation, and rises in irritability and nocturnal wakings, had recovered by day 4 or earlier, and bowel activity was less frequent, with harder stools, on days 1 and 2 only. Also, on day 1, there was a decrease in the ease of getting to sleep (- 1.33 +/- 0.55), but this changed to an increase from day 2 onwards (for example, + 0.75 +/- 0.25 on day 6). Stepwise regression analysis was used to investigate predictors of jet-lag. The severity of jet-lag at all the times that were measured was strongly predicted by fatigue ratings made at the same time. Its severity at 08:00 h was predicted by an earlier time of waking, by feeling less alert 30 min after waking and, marginally, by the number of waking episodes. Jet-lag at 12:00 and 16:00 h was strongly predicted by a fall of concentration at these times; jet-lag at mealtimes (12:00, 16:00 and 20:00 h) was predicted by the amount of feeling bloated. Such results complicate an exact interpretation that can be

  1. Recent trends for drug lag in clinical development of oncology drugs in Japan: does the oncology drug lag still exist in Japan?

    PubMed

    Maeda, Hideki; Kurokawa, Tatsuo

    2015-12-01

    This study exhaustively and historically investigated the status of drug lag for oncology drugs approved in Japan. We comprehensively investigated oncology drugs approved in Japan between April 2001 and July 2014, using publicly available information. We also examined changes in the status of drug lag between Japan and the United States, as well as factors influencing drug lag. This study included 120 applications for approval of oncology drugs in Japan. The median difference over a 13-year period in the approval date between the United States and Japan was 875 days (29.2 months). This figure peaked in 2002, and showed a tendency to decline gradually each year thereafter. In 2014, the median approval lag was 281 days (9.4 months). Multiple regression analysis identified the following potential factors that reduce drug lag: "Japan's participation in global clinical trials"; "bridging strategies"; "designation of priority review in Japan"; and "molecularly targeted drugs". From 2001 to 2014, molecularly targeted drugs emerged as the predominant oncology drug, and the method of development has changed from full development in Japan or bridging strategy to global simultaneous development by Japan's taking part in global clinical trials. In line with these changes, the drug lag between the United States and Japan has significantly reduced to less than 1 year.

  2. On the phase lag of turbulent dissipation in rotating tidal flows

    NASA Astrophysics Data System (ADS)

    Zhang, Qianjiang; Wu, Jiaxue

    2018-03-01

    Field observations of rotating tidal flows in a shallow tidally swept sea reveal that a notable phase lag of both shear production and turbulent dissipation increases with height above the seafloor. These vertical delays of turbulent quantities are approximately equivalent in magnitude to that of squared mean shear. The shear production approximately equals turbulent dissipation over the phase-lag column, and thus a main mechanism of phase lag of dissipation is mean shear, rather than vertical diffusion of turbulent kinetic energy. By relating the phase lag of dissipation to that of the mean shear, a simple formulation with constant eddy viscosity is developed to describe the phase lag in rotating tidal flows. An analytical solution indicates that the phase lag increases linearly with height subjected to a combined effect of tidal frequency, Coriolis parameter and eddy viscosity. The vertical diffusion of momentum associated with eddy viscosity produces the phase lag of squared mean shear, and resultant delay of turbulent quantities. Its magnitude is inhibited by Earth's rotation. Furthermore, a theoretical formulation of the phase lag with a parabolic eddy viscosity profile can be constructed. A first-order approximation of this formulation is still a linear function of height, and its magnitude is approximately 0.8 times that with constant viscosity. Finally, the theoretical solutions of phase lag with realistic viscosity can be satisfactorily justified by realistic phase lags of dissipation.

  3. Hamiltonian model and dynamic analyses for a hydro-turbine governing system with fractional item and time-lag

    NASA Astrophysics Data System (ADS)

    Xu, Beibei; Chen, Diyi; Zhang, Hao; Wang, Feifei; Zhang, Xinguang; Wu, Yonghong

    2017-06-01

    This paper focus on a Hamiltonian mathematical modeling for a hydro-turbine governing system including fractional item and time-lag. With regards to hydraulic pressure servo system, a universal dynamical model is proposed, taking into account the viscoelastic properties and low-temperature impact toughness of constitutive materials as well as the occurrence of time-lag in the signal transmissions. The Hamiltonian model of the hydro-turbine governing system is presented using the method of orthogonal decomposition. Furthermore, a novel Hamiltonian function that provides more detailed energy information is presented, since the choice of the Hamiltonian function is the key issue by putting the whole dynamical system to the theory framework of the generalized Hamiltonian system. From the numerical experiments based on a real large hydropower station, we prove that the Hamiltonian function can describe the energy variation of the hydro-turbine suitably during operation. Moreover, the effect of the fractional α and the time-lag τ on the dynamic variables of the hydro-turbine governing system are explored and their change laws identified, respectively. The physical meaning between fractional calculus and time-lag are also discussed in nature. All of the above theories and numerical results are expected to provide a robust background for the safe operation and control of large hydropower stations.

  4. Lag Times and Peak Coefficients for Rural Watersheds in Kansas

    DOT National Transportation Integrated Search

    1999-10-01

    Lag time is an essential input to the most common synthetic unit-hydrograph models. The lag time for an ungaged stream must be estimated from the physical characteristics of the stream and its watershed. In this study, a lag-time formula for small ru...

  5. Intimate Partner Aggression and Marital Satisfaction: A Cross-Lagged Panel Analysis.

    PubMed

    Hammett, Julia F; Lavner, Justin A; Karney, Benjamin R; Bradbury, Thomas N

    2017-12-01

    Intimate partner aggression is common in dissatisfied relationships, yet it remains unclear whether intimate partner aggression is a correlate of relationship satisfaction, whether it predicts or follows from relationship satisfaction over time, or whether longitudinal associations are in fact bidirectional in nature. The present study evaluates these perspectives by examining self-reports of aggressive behaviors in relation to corresponding self-reports of relationship satisfaction among a sample of 431 low-income, ethnically diverse (76% Hispanic, 12% African American, 12% Caucasian) newlywed couples. Using a cross-lagged panel analysis, we examined associations between aggression and satisfaction across four time points, spaced by 9-month intervals, during the first 2.5 years of marriage. Cross-sectionally, less satisfied couples reported higher levels of intimate partner aggression. Longitudinally, aggression was a more consistent predictor of satisfaction than vice versa, though neither pathway was particularly robust: Intimate partner aggression was a significant predictor of relationship satisfaction at 4 of the 12 tested lags, whereas relationship satisfaction was a significant predictor of intimate partner aggression at only one of 12 lags. Because all effects were relatively weak and inconsistent, more specificity is needed to clarify circumstances under which aggression does and does not predict satisfaction, including whether the predictive power of the aggression-to-satisfaction association varies based on the severity of aggression or other individual (e.g., personality) or external (e.g., stress and environmental context) factors. Together, results indicate that dissatisfied couples are more likely to engage in intimate partner aggression, but being dissatisfied is unlikely to increase the level of aggression a couple engages in over time.

  6. Mitigating shear lag in tall buildings

    NASA Astrophysics Data System (ADS)

    Gaur, Himanshu; Goliya, Ravindra K.

    2015-09-01

    As the height of building increases, effect of shear lag also becomes considerable in the design of high-rise buildings. In this paper, shear lag effect in tall buildings of heights, i.e., 120, 96, 72, 48 and 36 stories of which aspect ratio ranges from 3 to 10 is studied. Tube-in-tube structural system with façade bracing is used for designing the building of height 120 story. It is found that bracing system considerably reduces the shear lag effect and hence increases the building stiffness to withstand lateral loads. Different geometric patterns of bracing system are considered. The best effective geometric configuration of bracing system is concluded in this study. Lateral force, as wind load is applied on the buildings as it is the most dominating lateral force for such heights. Wind load is set as per Indian standard code of practice IS 875 Part-3. For analysis purpose SAP 2000 software program is used.

  7. Kinetic analysis of elastomeric lag damper for helicopter rotors

    NASA Astrophysics Data System (ADS)

    Liu, Yafang; Wang, Jidong; Tong, Yan

    2018-02-01

    The elastomeric lag dampers suppress the ground resonance and air resonance that play a significant role in the stability of the helicopter. In this paper, elastomeric lag damper which is made from silicone rubber is built. And a series of experiments are conducted on this elastomeric lag damper. The stress-strain curves of elastomeric lag dampers employed shear forces at different frequency are obtained. And a finite element model is established based on Burgers model. The result of simulation and tests shows that the simple, linear model will yield good predictions of damper energy dissipation and it is adequate for predicting the stress-strain hysteresis loop within the operating frequency and a small-amplitude oscillation.

  8. A Flight-Dynamic Helicopter Mathematical Model with a Single Flap-Lag- Torsion Main Rotor

    DTIC Science & Technology

    1990-02-01

    allows several hinge sequences and two offsets in the hinges. Quasi-steady Greenberg theory is used to calculate the blade-section aerodynamic forces...steady Greenberg model is used (ref. 3), Unsteady inflow effects are included using the three-state nonlinear Pitt/Peters dynamic inflow model (ref. 4...sectional aerodynamic model is based on quasi-steady Greenberg theory, which is a Theodorsen theory modified to account for lead-lag motions (refs. 3,14). The

  9. GHRH excess and blockade in X-LAG syndrome.

    PubMed

    Daly, Adrian F; Lysy, Philippe A; Desfilles, Céline; Rostomyan, Liliya; Mohamed, Amira; Caberg, Jean-Hubert; Raverot, Veronique; Castermans, Emilie; Marbaix, Etienne; Maiter, Dominique; Brunelle, Chloe; Trivellin, Giampaolo; Stratakis, Constantine A; Bours, Vincent; Raftopoulos, Christian; Beauloye, Veronique; Barlier, Anne; Beckers, Albert

    2016-03-01

    X-linked acrogigantism (X-LAG) syndrome is a newly described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated GH and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GHRH levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(d-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. © 2016 Society for Endocrinology.

  10. TRACING THE REVERBERATION LAG IN THE HARD STATE OF BLACK HOLE X-RAY BINARIES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    De Marco, B.; Ponti, G.; Nandra, K.

    2015-11-20

    We report results obtained from a systematic analysis of X-ray lags in a sample of black hole X-ray binaries, with the aim of assessing the presence of reverberation lags and studying their evolution during outburst. We used XMM-Newton and simultaneous Rossi X-ray Timing Explorer (RXTE) observations to obtain broadband energy coverage of both the disk and the hard X-ray Comptonization components. In most cases the detection of reverberation lags is hampered by low levels of variability-power signal-to-noise ratio (typically when the source is in a soft state) and/or short exposure times. The most detailed study was possible for GX 339-4more » in the hard state, which allowed us to characterize the evolution of X-ray lags as a function of luminosity in a single source. Over all the sampled frequencies (∼0.05–9 Hz), we observe the hard lags intrinsic to the power-law component, already well known from previous RXTE studies. The XMM-Newton soft X-ray response allows us to detail the disk variability. At low frequencies (long timescales) the disk component always leads the power-law component. On the other hand, a soft reverberation lag (ascribable to thermal reprocessing) is always detected at high frequencies (short timescales). The intrinsic amplitude of the reverberation lag decreases as the source luminosity and the disk fraction increase. This suggests that the distance between the X-ray source and the region of the optically thick disk where reprocessing occurs gradually decreases as GX 339-4 rises in luminosity through the hard state, possibly as a consequence of reduced disk truncation.« less

  11. 14 CFR Section 1 - Introduction to System of Accounts and Reports

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIR CARRIERS General Accounting Provisions Section 1 Introduction to System of Accounts and Reports ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Introduction to System of Accounts and Reports Section 1 Section 1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION...

  12. Spectral evolution of GRBs with negative spectral lag using Fermi GBM observations

    NASA Astrophysics Data System (ADS)

    Chakrabarti, Arundhati; Chaudhury, Kishor; Sarkar, Samir K.; Bhadra, Arunava

    2018-06-01

    The positive spectral lag of Gamma Ray Bursts (GRBs) is often explained in terms of hard-to-soft spectral evolution of GRB pulses. While positive lags of GRBs is very common, there are few GRB pulses that exhibits negative spectral lags. In the present work we examine whether negative lags of GRBs also can be interpreted in terms of spectral evolution of GRB pulses or not. Using Fermi-GBM data, we identify two GRBs, GRB 090426C and GRB 150213A, with clean pulses that exhibit negative spectral lag. An indication of soft to hard transition has been noticed for the negative spectral lag events from the spectral evolution study. The implication of the present findings on the models of GRB spectral lags are discussed.

  13. Accounting principles, reporting rules, and payment practices.

    PubMed

    Kovener, R R

    1979-12-01

    Misconceptions concerning the distinction between accounting principles, reporting rules, and payment practices and how they interrelate can lessen the effectiveness of hospital financial managers in these areas/clarification and recommendations are offered.

  14. Report of the Joint Accounting Group.

    ERIC Educational Resources Information Center

    Western Interstate Commission for Higher Education, Boulder, CO. National Center for Higher Education Management Systems.

    The Joint Accounting Group (JAG) has as its primary goal to develop a capability to provide uniform transactional finance data at the institutional level. Such data should effectively meet the needs of public reporting, institutional financial management, and program planning. The group believes that the attainment of this goal requires uniformly…

  15. Emergence and temporal structure of Lead-Lag correlations in collective stock dynamics

    NASA Astrophysics Data System (ADS)

    Xia, Lisi; You, Daming; Jiang, Xin; Chen, Wei

    2018-07-01

    Understanding the correlations among stock returns is crucial for reducing the risk of investment in stock markets. As an important stylized correlation, lead-lag effect plays a major role in analyzing market volatility and deriving trading strategies. Here, we explore historical lead-lag relationships among stocks in the Chinese stock market. Strongly positive lagged correlations can be empirically observed. We demonstrate this lead-lag phenomenon is not constant but temporally emerges during certain periods. By introducing moving time window method, we transform the lead-lag dynamics into a series of asymmetric lagged correlation matrices. Dynamic lead-lag structures are uncovered in the form of temporal network structures. We find that the size of lead-lag group experienced a rapid drop during the year 2012, which signaled a re-balance of the stock market. On the daily timescale, we find the lead-lag structure exhibits several persistent patterns, which can be characterized by the Jaccard matrix. We show significant market events can be distinguished in the Jaccard matrix diagram. Taken together, we study an integration of all the temporal networks and identify several leading stock sectors, which are in accordance with the common Chinese economic fundamentals.

  16. Burst Statistics Using the Lag-Luminosity Relationship

    NASA Technical Reports Server (NTRS)

    Band, D. L.; Norris, J. P.; Bonnell, J. T.

    2003-01-01

    Using the lag-luminosity relation and various BATSE catalogs we create a large catalog of burst redshifts, peak luminosities and emitted energies. These catalogs permit us to evaluate the lag-luminosity relation, and to study the burst energy distribution. We find that this distribution can be described as a power law with an index of alpha = 1.76 +/- 0.05 (95% confidence), close to the alpha = 2 predicted by the original quasi-universal jet model.

  17. Performance and Accountability Report

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The NASA Fiscal Year 2002 Performance and Accountability Report is presented. Over the past year, significant changes have been implemented to greatly improve NASA's management while continuing to break new ground in science and technology. Excellent progress has been made in implementing the President's Management Agenda. NASA is leading the government in its implementation of the five government-wide initiatives. NASA received an unqualified audit opinion on FY 2002 financial statements. The vast majority of performance goals have been achieved, furthering each area of NASA's mission. The contents include: 1) NASA Vision and Mission; 2) Management's Discussion and Analysis; 3) Performance; and 4) Financial.

  18. Monthly ENSO Forecast Skill and Lagged Ensemble Size

    PubMed Central

    DelSole, T.; Tippett, M.K.; Pegion, K.

    2018-01-01

    Abstract The mean square error (MSE) of a lagged ensemble of monthly forecasts of the Niño 3.4 index from the Climate Forecast System (CFSv2) is examined with respect to ensemble size and configuration. Although the real‐time forecast is initialized 4 times per day, it is possible to infer the MSE for arbitrary initialization frequency and for burst ensembles by fitting error covariances to a parametric model and then extrapolating to arbitrary ensemble size and initialization frequency. Applying this method to real‐time forecasts, we find that the MSE consistently reaches a minimum for a lagged ensemble size between one and eight days, when four initializations per day are included. This ensemble size is consistent with the 8–10 day lagged ensemble configuration used operationally. Interestingly, the skill of both ensemble configurations is close to the estimated skill of the infinite ensemble. The skill of the weighted, lagged, and burst ensembles are found to be comparable. Certain unphysical features of the estimated error growth were tracked down to problems with the climatology and data discontinuities. PMID:29937973

  19. Monthly ENSO Forecast Skill and Lagged Ensemble Size

    NASA Astrophysics Data System (ADS)

    Trenary, L.; DelSole, T.; Tippett, M. K.; Pegion, K.

    2018-04-01

    The mean square error (MSE) of a lagged ensemble of monthly forecasts of the Niño 3.4 index from the Climate Forecast System (CFSv2) is examined with respect to ensemble size and configuration. Although the real-time forecast is initialized 4 times per day, it is possible to infer the MSE for arbitrary initialization frequency and for burst ensembles by fitting error covariances to a parametric model and then extrapolating to arbitrary ensemble size and initialization frequency. Applying this method to real-time forecasts, we find that the MSE consistently reaches a minimum for a lagged ensemble size between one and eight days, when four initializations per day are included. This ensemble size is consistent with the 8-10 day lagged ensemble configuration used operationally. Interestingly, the skill of both ensemble configurations is close to the estimated skill of the infinite ensemble. The skill of the weighted, lagged, and burst ensembles are found to be comparable. Certain unphysical features of the estimated error growth were tracked down to problems with the climatology and data discontinuities.

  20. Signatures of Steady Heating in Time Lag Analysis of Coronal Emission

    NASA Technical Reports Server (NTRS)

    Viall, Nicholeen M.; Klimchuk, James A.

    2016-01-01

    Among the multitude of methods used to investigate coronal heating, the time lag method of Viall Klimchuk is becoming increasingly prevalent as an analysis technique that is complementary to those that are traditionally used.The time lag method cross correlates light curves at a given spatial location obtained in spectral bands that sample different temperature plasmas. It has been used most extensively with data from the Atmospheric Imaging Assembly on the Solar Dynamics Observatory. We have previously applied the time lag method to entire active regions and surrounding the quiet Sun and created maps of the results. We find that the majority of time lags are consistent with the cooling of coronal plasma that has been impulsively heated. Additionally, a significant fraction of the map area has a time lag of zero. This does not indicate a lack of variability. Rather, strong variability must be present, and it must occur in phase between the different channels. We have previously shown that these zero time lags are consistent with the transition region response to coronal nanoflares, although other explanations are possible. A common misconception is that the zero time lag indicates steady emission resulting from steady heating. Using simulated and observed light curves, we demonstrate here that highly correlated light curves at zero time lag are not compatible with equilibrium solutions. Such light curves can only be created by evolution

  1. LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.

    PubMed

    Cook, Kevin D; Whitmire, Jason K

    2016-07-01

    Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8(+) T cells during chronic virus infection and antitumor responses. However, the T cell response in LAG-3-deficient mice is similar in size and function to that in wild type animals, suggesting LAG-3 has nuanced immune-regulatory functions. We performed a series of adoptive transfer experiments in mice to better understand the T cell-intrinsic functions of LAG-3 in the regulation of CD8(+) T cell responses. Our results indicate that LAG-3 expression by CD8(+) T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison with LAG-3-deficient cells. This cell-intrinsic effect of LAG-3 was consistent across both acute and chronic virus infections. These data show that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8(+) T cell responses. Copyright © 2016 by The American Association of Immunologists, Inc.

  2. Consequences of Fluid Lag in Three-Dimensional Hydraulic Fractures

    NASA Astrophysics Data System (ADS)

    Advani (Deceased), S. H.; Lee, T. S.; Dean, R. H.; Pak, C. K.; Avasthi, J. M.

    1997-04-01

    Research investigations on three-dimensional (3-D) rectangular hydraulic fracture configurations with varying degrees of fluid lag are reported. This paper demonstrates that a 3-D fracture model coupled with fluid lag (a small region of reduced pressure) at the fracture tip can predict very large excess pressure measurements for hydraulic fracture processes. Predictions of fracture propagation based on critical stress intensity factors are extremely sensitive to the pressure profile at the tip of a propagating fracture. This strong sensitivity to the pressure profile at the tip of a hydraulic fracture is more strongly pronounced in 3-D models versus 2-D models because 3-D fractures are clamped at the top and bottom, and pressures in the 3-D fractures that are far removed from the fracture tip have little effect on the stress intensity factor at the fracture tip. This rationale for the excess pressure mechanism is in marked contrast to the crack tip process damage zone assumptions and attendant high rock fracture toughness value hypotheses advanced in the literature. A comparison with field data is presented to illustrate the proposed fracture fluid pressure sensitivity phenomenon. This paper does not attempt to calculate the length of the fluid lag region in a propagating fracture but instead attempts to show that the pressure profile at the tip of the propagating fracture plays a major role in fracture propagation, and this role is magnified in 3-D models. Int. J. Numer. Anal. Meth. Geomech., vol. 21, 229-240 (1997).

  3. Statistical shear lag model - unraveling the size effect in hierarchical composites.

    PubMed

    Wei, Xiaoding; Filleter, Tobin; Espinosa, Horacio D

    2015-05-01

    Numerous experimental and computational studies have established that the hierarchical structures encountered in natural materials, such as the brick-and-mortar structure observed in sea shells, are essential for achieving defect tolerance. Due to this hierarchy, the mechanical properties of natural materials have a different size dependence compared to that of typical engineered materials. This study aimed to explore size effects on the strength of bio-inspired staggered hierarchical composites and to define the influence of the geometry of constituents in their outstanding defect tolerance capability. A statistical shear lag model is derived by extending the classical shear lag model to account for the statistics of the constituents' strength. A general solution emerges from rigorous mathematical derivations, unifying the various empirical formulations for the fundamental link length used in previous statistical models. The model shows that the staggered arrangement of constituents grants composites a unique size effect on mechanical strength in contrast to homogenous continuous materials. The model is applied to hierarchical yarns consisting of double-walled carbon nanotube bundles to assess its predictive capabilities for novel synthetic materials. Interestingly, the model predicts that yarn gauge length does not significantly influence the yarn strength, in close agreement with experimental observations. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  4. Modeling time-lagged reciprocal psychological empowerment-performance relationships.

    PubMed

    Maynard, M Travis; Luciano, Margaret M; D'Innocenzo, Lauren; Mathieu, John E; Dean, Matthew D

    2014-11-01

    Employee psychological empowerment is widely accepted as a means for organizations to compete in increasingly dynamic environments. Previous empirical research and meta-analyses have demonstrated that employee psychological empowerment is positively related to several attitudinal and behavioral outcomes including job performance. While this research positions psychological empowerment as an antecedent influencing such outcomes, a close examination of the literature reveals that this relationship is primarily based on cross-sectional research. Notably, evidence supporting the presumed benefits of empowerment has failed to account for potential reciprocal relationships and endogeneity effects. Accordingly, using a multiwave, time-lagged design, we model reciprocal relationships between psychological empowerment and job performance using a sample of 441 nurses from 5 hospitals. Incorporating temporal effects in a staggered research design and using structural equation modeling techniques, our findings provide support for the conventional positive correlation between empowerment and subsequent performance. Moreover, accounting for the temporal stability of variables over time, we found support for empowerment levels as positive influences on subsequent changes in performance. Finally, we also found support for the reciprocal relationship, as performance levels were shown to relate positively to changes in empowerment over time. Theoretical and practical implications of the reciprocal psychological empowerment-performance relationships are discussed. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  5. The drug lag: an interpretive review of the literature.

    PubMed

    Schifrin, L G; Tayan, J R

    1977-01-01

    This articel reviews the literature pertinent to the "drug lag" issue, in order to evaluate the evidence underlying the thesis that the U.S. has suffered from a slow-down in the rate and timing of new drug introductions, to the detriment of patients, because of the stricter requirements since 1962 regarding proof of safety and efficacy for new drugs. Comparing the post-1962 record in the U.S. with (a) the U.S. record before 1962 and (b) the post-1962 record in other, mainly Western European, countries, the weight of evidence and argument falls on the side of those who see a lag existing in the U.S. Other evidence, more subjective, supports the view that this lag imposes net positive costs on U.S. patients. However, it is not clear that the 1962 Drug Act is the sole, or even the main, cause of the lag. Instead, the drug information system and its inefficiencies emerge as the fundamental reason for the existence of a lag; hence, changes in the administration of the law by the Food and Drug Administration and greater efficiency by companies in supporting New Drug Applications can help close the gap, but probably only in minor degree. The solution to the lag problem lies in formulating and implementing a drug information system that quickly and accurately gathers, interprets, and disseminates information on the positive and negative effects of newly introduced drugs; with such a system, protection of drug users from undue risk is compatible with a greater rate and more rapid appearance of new drug discoveries.

  6. Improving the effectiveness of an interruption lag by inducing a memory-based strategy.

    PubMed

    Morgan, Phillip L; Patrick, John; Tiley, Leyanne

    2013-01-01

    The memory for goals model (Altmann & Trafton, 2002) posits the importance of a short delay (the 'interruption lag') before an interrupting task to encode suspended goals for retrieval post-interruption. Two experiments used the theory of soft constraints (Gray, Simms, Fu & Schoelles, 2006) to investigate whether the efficacy of an interruption lag could be improved by increasing goal-state access cost to induce a more memory-based encoding strategy. Both experiments used a copying task with three access cost conditions (Low, Medium, and High) and a 5-s interruption lag with a no lag control condition. Experiment 1 found that the participants in the High access cost condition resumed more interrupted trials and executed more actions correctly from memory when coupled with an interruption lag. Experiment 2 used a prospective memory test post-interruption and an eyetracker recorded gaze activity during the interruption lag. The participants in the High access cost condition with an interruption lag were best at encoding target information during the interruption lag, evidenced by higher scores on the prospective memory measure and more gaze activity on the goal-state during the interruption lag. Theoretical and practical issues regarding the use of goal-state access cost and an interruption lag are discussed. Copyright © 2012. Published by Elsevier B.V.

  7. 7 CFR 993.173 - Reports of accounting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports of accounting. 993.173 Section 993.173 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN...

  8. Modelling of capital asset pricing by considering the lagged effects

    NASA Astrophysics Data System (ADS)

    Sukono; Hidayat, Y.; Bon, A. Talib bin; Supian, S.

    2017-01-01

    In this paper the problem of modelling the Capital Asset Pricing Model (CAPM) with the effect of the lagged is discussed. It is assumed that asset returns are analysed influenced by the market return and the return of risk-free assets. To analyse the relationship between asset returns, the market return, and the return of risk-free assets, it is conducted by using a regression equation of CAPM, and regression equation of lagged distributed CAPM. Associated with the regression equation lagged CAPM distributed, this paper also developed a regression equation of Koyck transformation CAPM. Results of development show that the regression equation of Koyck transformation CAPM has advantages, namely simple as it only requires three parameters, compared with regression equation of lagged distributed CAPM.

  9. Draft federal GHG accounting and reporting : technical support document

    DOT National Transportation Integrated Search

    2010-07-01

    This is a technical support document (TSD) that accompanies the Federal Greenhouse Gas Accounting and Reporting Guidance (or Guidance). This document provides detailed information on the inventory reporting process and accepted calculation methodolog...

  10. Multivariate dynamic Tobit models with lagged observed dependent variables: An effectiveness analysis of highway safety laws.

    PubMed

    Dong, Chunjiao; Xie, Kun; Zeng, Jin; Li, Xia

    2018-04-01

    Highway safety laws aim to influence driver behaviors so as to reduce the frequency and severity of crashes, and their outcomes. For one specific highway safety law, it would have different effects on the crashes across severities. Understanding such effects can help policy makers upgrade current laws and hence improve traffic safety. To investigate the effects of highway safety laws on crashes across severities, multivariate models are needed to account for the interdependency issues in crash counts across severities. Based on the characteristics of the dependent variables, multivariate dynamic Tobit (MVDT) models are proposed to analyze crash counts that are aggregated at the state level. Lagged observed dependent variables are incorporated into the MVDT models to account for potential temporal correlation issues in crash data. The state highway safety law related factors are used as the explanatory variables and socio-demographic and traffic factors are used as the control variables. Three models, a MVDT model with lagged observed dependent variables, a MVDT model with unobserved random variables, and a multivariate static Tobit (MVST) model are developed and compared. The results show that among the investigated models, the MVDT models with lagged observed dependent variables have the best goodness-of-fit. The findings indicate that, compared to the MVST, the MVDT models have better explanatory power and prediction accuracy. The MVDT model with lagged observed variables can better handle the stochasticity and dependency in the temporal evolution of the crash counts and the estimated values from the model are closer to the observed values. The results show that more lives could be saved if law enforcement agencies can make a sustained effort to educate the public about the importance of motorcyclists wearing helmets. Motor vehicle crash-related deaths, injuries, and property damages could be reduced if states enact laws for stricter text messaging rules, higher

  11. 46 CFR 403.100 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accordance with the guidelines of the Generally Accepted Accounting Principles (GAAP) issued by the Financial Accounting Standards Board. These guidelines are available by writing to the Director, Great Lakes Pilotage... PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.100 Applicability of system of accounts and reports. Each...

  12. 7 CFR 1781.21 - Borrower accounting methods, management, reporting, and audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Borrower accounting methods, management, reporting... DEVELOPMENT (RCD) LOANS AND WATERSHED (WS) LOANS AND ADVANCES § 1781.21 Borrower accounting methods, management, reporting, and audits. These activities will be handled in accordance with the provisions of...

  13. 14 CFR Sec. 1-1 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Applicability of system of accounts and reports. Sec. 1-1 Section 1-1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... AIR CARRIERS General Accounting Provisions Sec. 1-1 Applicability of system of accounts and reports...

  14. 14 CFR Sec. 1-1 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Applicability of system of accounts and reports. Sec. 1-1 Section 1-1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... AIR CARRIERS General Accounting Provisions Sec. 1-1 Applicability of system of accounts and reports...

  15. 14 CFR Sec. 1-1 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Applicability of system of accounts and reports. Sec. 1-1 Section 1-1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... AIR CARRIERS General Accounting Provisions Sec. 1-1 Applicability of system of accounts and reports...

  16. 14 CFR Sec. 1-1 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Applicability of system of accounts and reports. Sec. 1-1 Section 1-1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... AIR CARRIERS General Accounting Provisions Sec. 1-1 Applicability of system of accounts and reports...

  17. Changes in plant community composition lag behind climate warming in lowland forests.

    PubMed

    Bertrand, Romain; Lenoir, Jonathan; Piedallu, Christian; Riofrío-Dillon, Gabriela; de Ruffray, Patrice; Vidal, Claude; Pierrat, Jean-Claude; Gégout, Jean-Claude

    2011-10-19

    Climate change is driving latitudinal and altitudinal shifts in species distribution worldwide, leading to novel species assemblages. Lags between these biotic responses and contemporary climate changes have been reported for plants and animals. Theoretically, the magnitude of these lags should be greatest in lowland areas, where the velocity of climate change is expected to be much greater than that in highland areas. We compared temperature trends to temperatures reconstructed from plant assemblages (observed in 76,634 surveys) over a 44-year period in France (1965-2008). Here we report that forest plant communities had responded to 0.54 °C of the effective increase of 1.07 °C in highland areas (500-2,600 m above sea level), while they had responded to only 0.02 °C of the 1.11 °C warming trend in lowland areas. There was a larger temperature lag (by 3.1 times) between the climate and plant community composition in lowland forests than in highland forests. The explanation of such disparity lies in the following properties of lowland, as compared to highland, forests: the higher proportion of species with greater ability for local persistence as the climate warms, the reduced opportunity for short-distance escapes, and the greater habitat fragmentation. Although mountains are currently considered to be among the ecosystems most threatened by climate change (owing to mountaintop extinction), the current inertia of plant communities in lowland forests should also be noted, as it could lead to lowland biotic attrition. ©2011 Macmillan Publishers Limited. All rights reserved

  18. Time-lag effects of global vegetation responses to climate change.

    PubMed

    Wu, Donghai; Zhao, Xiang; Liang, Shunlin; Zhou, Tao; Huang, Kaicheng; Tang, Bijian; Zhao, Wenqian

    2015-09-01

    Climate conditions significantly affect vegetation growth in terrestrial ecosystems. Due to the spatial heterogeneity of ecosystems, the vegetation responses to climate vary considerably with the diverse spatial patterns and the time-lag effects, which are the most important mechanism of climate-vegetation interactive effects. Extensive studies focused on large-scale vegetation-climate interactions use the simultaneous meteorological and vegetation indicators to develop models; however, the time-lag effects are less considered, which tends to increase uncertainty. In this study, we aim to quantitatively determine the time-lag effects of global vegetation responses to different climatic factors using the GIMMS3g NDVI time series and the CRU temperature, precipitation, and solar radiation datasets. First, this study analyzed the time-lag effects of global vegetation responses to different climatic factors. Then, a multiple linear regression model and partial correlation model were established to statistically analyze the roles of different climatic factors on vegetation responses, from which the primary climate-driving factors for different vegetation types were determined. The results showed that (i) both the time-lag effects of the vegetation responses and the major climate-driving factors that significantly affect vegetation growth varied significantly at the global scale, which was related to the diverse vegetation and climate characteristics; (ii) regarding the time-lag effects, the climatic factors explained 64% variation of the global vegetation growth, which was 11% relatively higher than the model ignoring the time-lag effects; (iii) for the area with a significant change trend (for the period 1982-2008) in the global GIMMS3g NDVI (P < 0.05), the primary driving factor was temperature; and (iv) at the regional scale, the variation in vegetation growth was also related to human activities and natural disturbances. Considering the time-lag effects is quite

  19. 31 CFR 281.8 - Reporting and accounting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Reporting and accounting. 281.8 Section 281.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FOREIGN EXCHANGE OPERATIONS § 281.8...

  20. Stronger by Degrees: 2012-13 Accountability Report

    ERIC Educational Resources Information Center

    Kentucky Council on Postsecondary Education, 2014

    2014-01-01

    The annual "Accountability Report" produced by the Council on Postsecondary Education highlights the system's performance on the state-level metrics included in "Stronger by Degrees: A Strategic Agenda for Kentucky Postsecondary and Adult Education." For each metric, we outline steps taken to improve performance, as well as…

  1. 10 CFR 63.78 - Material control and accounting records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Material control and accounting records and reports. 63.78 Section 63.78 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES... Material control and accounting records and reports. DOE shall implement a program of material control and...

  2. Higher Education Counts: Accountability Measures for the New Millennium. 2005 Report

    ERIC Educational Resources Information Center

    Connecticut Department of Higher Education (NJ1), 2005

    2005-01-01

    "Higher Education Counts" is the annual accountability report on Connecticut's state system of higher education, as required under Connecticut General Statutes Section 10a-6a. The report contains accountability measures developed through the Performance Measures Task Force and approved by the Board of Governors for Higher Education. The…

  3. 7 CFR 1942.128 - Borrower accounting methods, management reports and audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Borrower accounting methods, management reports and... Rescue and Other Small Community Facilities Projects § 1942.128 Borrower accounting methods, management... under Public Law 103-354 1942-53, “Cash Flow Report,” instead of page one of schedule one and schedule...

  4. National Aeronautics and Space Administration: 1998 Accountability Report

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This Accountability Report summarizes NASA's program accomplishments and its stewardship over budget and financial resources. The report is the culmination of NASA's management process, which begins with mission definition and program planning, continues with formulation and justification of NASA's budgets for the President and Congress, and ends with NASA scientific and engineering program accomplishments. This report covers NASA's activities from October 1, 1997, through September 30, 1998, with discussion of some subsequent events.

  5. LAG-3 confers a competitive disadvantage upon antiviral CD8+ T cell responses1

    PubMed Central

    Cook, Kevin D.; Whitmire, Jason K.

    2016-01-01

    Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8+ T cells during chronic virus infection and anti-tumor responses. However, the T cell response in LAG-3 deficient mice is similar in size and function to that in wild type animals, suggesting LAG-3 has nuanced immune-regulatory functions. We performed a series of adoptive transfer experiments in mice to better understand the T cell-intrinsic functions of LAG-3 in the regulation of CD8+ T cell responses. Our results indicate that LAG-3 expression by CD8+ T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison to LAG-3 deficient cells. This cell-intrinsic effect of LAG-3 was consistent across both acute and chronic virus infections. These data show that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8+ T cell responses. PMID:27206765

  6. The Effects of ’Jet-Lag’ on Exercise Performance,

    DTIC Science & Technology

    1983-05-11

    The Effects of "Jet-Lag" on Exercise Performance ’ 6. PERFORMING ORG. REPORT NUMBER ~E AUTHOR(a) 6. CONTRACT OR GRANT NUMBER(&) James A. Vogel, Ph.D. 0... PERFORMING ORGANIZATION NAME AND ADDRESS SO. PROGRAM ELEMENT. PROJECT. TASK UAryResearch Isite of Ernetal AREA & WORK UNIT NUMBERS Medicine, Natick...entered In Block 20, If different from JU 7 193 IS. SUPPLEMENTARY NOTES To be published in Medicine Science in Sports and Exercise as a Symposium III

  7. A Race Against Time: Time Lags in Terrestrial-Aquatic Linkages

    NASA Astrophysics Data System (ADS)

    Basu, N. B.

    2017-12-01

    Unprecedented decreases in atmospheric nitrogen (N) deposition together with increases in agricultural N-use efficiency have led to decreases in net anthropogenic N inputs in many eastern U.S. and Canadian watersheds as well as in Europe. Despite such decreases, N concentrations in streams and rivers continue to increase, and problems of coastal eutrophication remain acute. Such a mismatch between N inputs and outputs can arise due to legacy N accumulation and subsequent lag times between implementation of conservation measures and improvements in water quality. In the present study, we quantified such lag times by pairing long-term N input trajectories with stream N concentration data in multiple watersheds in North America. Results show significant nonlinearity between N inputs and outputs, with a strong hysteresis effect indicative of decadal-scale lag times. Lag times were found to be negatively correlated with both tile drainage and watershed slope, with tile drainage being a dominant control in fall and watershed slope being significant during the spring snowmelt period. Quantification of such lags will be crucial to policy-makers as they struggle to set appropriate goals for water quality improvement in human-impacted watersheds.

  8. Financial Accounting Concepts and DoN/DoD Financial Reporting Practice

    DTIC Science & Technology

    1993-03-01

    continue on reverse if necessary and identify by block number) FIELD GROUP SUBGROUP Financial accounting/reporting concepts. Depreciation , Inventory... DEPRECIATION ................ ................. 7 1. DEFINITION ............... ................ 7 2. CONTEXT ................. .................. 7 3...include; 1. Financial Reporting 2. Ratio Analysis for a Ships Store 3. Timing ° •sues 2 4. Inventory Accounting and Standard Pricing 5. Depreciation 6. Pro

  9. Cross-lagged relations among parenting, children's emotion regulation, and psychosocial adjustment in early adolescence.

    PubMed

    Otterpohl, Nantje; Wild, Elke

    2015-01-01

    Numerous studies have reported substantive correlations between indicators of parenting, children's emotion regulation (ER), and children's psychosocial adjustment. However, studies on underlying mechanisms are scarce. Particularly in early adolescence, it is still unclear whether relations between parenting and ER are caused by adolescent behavior, by parent behavior, or by reciprocal processes. Moreover, it is unclear whether ER can be seen as an antecedent or a consequence of psychosocial adjustment. The aim of this study was to examine predictive relations among parenting and adolescents' ER, and adolescents' ER and psychosocial adjustment, respectively. We collected longitudinal, multiple informant data at two measurement occasions (Grade 6, Grade 7). All told, 1,100 adolescents (10-14 years) and their parents filled out questionnaires assessing responsiveness and psychological control, adolescents' anger regulation, and adolescents' problem and prosocial behavior. Cross-lagged analyses revealed reciprocal effects between parenting, ER, and adjustment for the parent and boys', but not for the girls', report. Moreover, relations were different for adolescents with versus without clinically elevated symptoms of psychopathology. Our findings support the assumption that reciprocal relations between parenting, ER, and psychosocial adjustment are likely to persist until early adolescence. Nevertheless, the moderating role of gender and psychopathology should be taken into account. Possible reasons for the different findings, and practical implications, are discussed.

  10. Collective Dynamics of Oscillator Networks: Why do we suffer from heavy jet lag?

    NASA Astrophysics Data System (ADS)

    Kori, Hiroshi

    The circadian rhythm of the entire body in mammals is orchestrated by a small tissue in the brain called the suprachiamatic nucleus (SCN). The SCN consists of a population of neurons, each of which exhibit circadian (i.e., approximately 24 h) gene expression. Neurons form a complex network and interact with each other using various types of neurotransmitters. The rhythmic gene expressions of individual cells in the SCN synchronize through such interaction. Jet-lag symptoms arise from temporal mismatch between the internal circadian clock orchestrated by the SCN and external solar time. It may take about one week or even longer to recover from jet lag after a long-distance trip. We recently found that recovery from jet lag is considerably accelerated in the knocked-out (KO) mice lacking the receptors of a certain neurotransmitter in the SCN. Importantly, all other properties of mice including sleep-awake rhythms and breeding seem to be intact. Only the response to the jet lag changes. It was also found that after a few days of jet lag, cells in the SCN desynchronize in the wild type (WT) mice, whereas they do not in KO mice. This desynchrony might be a main reason for heavy jet lag symptoms. To understand the mechanism underlying jet lag, we propose a simple model of the SCN, which is a network of phase oscillators. Despite its simplicity, this model can reproduce important dynamical properties of the SCN. For example, this model reproduces the desynchrony of oscillators after jet lag. Moreover, when intercellular interaction is weaker, this desynchrony is suppressed and the recover from jet lag is considerably accelerated. Our mathematical study provides a deeper understanding of jet lag and an idea how to circumvent heavy jet lag symptoms

  11. 14 CFR 1-3 - General description of system of accounts and reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false General description of system of accounts and reports. Sec. 1-3 Section Sec. 1-3 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... reports. (a) This system of accounts and reports is designed to permit limited contraction or expansion to...

  12. Do the flash-lag effect and representational momentum involve similar extrapolations?

    PubMed Central

    Hubbard, Timothy L.

    2013-01-01

    In the flash-lag effect (FLE) and in representational momentum (RM), the represented position of a moving target is displaced in the direction of motion. Effects of numerous variables on the FLE and on RM are briefly considered. In many cases, variables appear to have the same effect on the FLE and on RM, and this is consistent with a hypothesis that displacements in the FLE and in RM result from overlapping or similar mechanisms. In other cases, variables initially appear to have different effects on the FLE and on RM, but accounts reconciling those apparent differences with a hypothesis of overlapping or similar mechanisms are suggested. Given that RM is simpler and accounts for a wider range of findings (i.e., RM involves a single stimulus rather than the relationship between two stimuli, RM accounts for displacement in absolute position of a single stimulus and for differences in relative position of two stimuli), it is suggested that (at least some cases of) the FLE might be a special case of RM in which the position of the target is assessed relative to the position of another stimulus (i.e., the flashed object) rather than relative to the actual position of the target. PMID:23734140

  13. Drinking, smoking, and educational achievement: Cross-lagged associations from adolescence to adulthood

    PubMed Central

    Latvala, Antti; Rose, Richard J.; Pulkkinen, Lea; Dick, Danielle M.; Korhonen, Tellervo; Kaprio, Jaakko

    2014-01-01

    Background Adolescent substance use is associated with lower educational achievement but the directionality of the association remains uncertain. We analyzed data on drinking, smoking and educational achievement to study the associations between substance use and education from early adolescence to young adulthood. Methods Longitudinal data from four time points (ages 12, 14, 17, and 19-27 years) from a population-based cohort study of Finnish twin individuals were used to estimate bivariate cross-lagged path models for substance use and educational achievement, adjusting for sex, parental covariates, and adolescent externalizing behavior. A total of 4,761 individuals (49.4% females) were included in the analyses. Educational achievement was assessed with teacher-reported grade point average at ages 12 and 14, and with self-reported student status and completed education at age 17 and in young adulthood. From self-reported questionnaire items, frequency of any drinking, frequency of drinking to intoxication, any smoking and daily smoking were analyzed. Results Alcohol use and smoking behaviors at ages 12 and 14 predicted lower educational achievement at later time points even after previous achievement and confounding factors were taken into account. Lower school achievement in adolescence predicted a higher likelihood of engaging in smoking behaviors but did not predict later alcohol use. Higher educational attainment at age 17 predicted more frequent drinking in young adulthood. Conclusions Adolescent drinking behaviors are associated with lower future educational achievement independently of prior achievement, whereas smoking both predicts and is predicted by lower achievement. Early substance use indexes elevated risk for poor educational outcomes. PMID:24548801

  14. Effective Iterated Greedy Algorithm for Flow-Shop Scheduling Problems with Time lags

    NASA Astrophysics Data System (ADS)

    ZHAO, Ning; YE, Song; LI, Kaidian; CHEN, Siyu

    2017-05-01

    Flow shop scheduling problem with time lags is a practical scheduling problem and attracts many studies. Permutation problem(PFSP with time lags) is concentrated but non-permutation problem(non-PFSP with time lags) seems to be neglected. With the aim to minimize the makespan and satisfy time lag constraints, efficient algorithms corresponding to PFSP and non-PFSP problems are proposed, which consist of iterated greedy algorithm for permutation(IGTLP) and iterated greedy algorithm for non-permutation (IGTLNP). The proposed algorithms are verified using well-known simple and complex instances of permutation and non-permutation problems with various time lag ranges. The permutation results indicate that the proposed IGTLP can reach near optimal solution within nearly 11% computational time of traditional GA approach. The non-permutation results indicate that the proposed IG can reach nearly same solution within less than 1% computational time compared with traditional GA approach. The proposed research combines PFSP and non-PFSP together with minimal and maximal time lag consideration, which provides an interesting viewpoint for industrial implementation.

  15. Drug Lag and Key Regulatory Barriers in the Emerging Markets

    PubMed Central

    Wileman, Harriet; Mishra, Arun

    2010-01-01

    There have been numerous investigations targeted at identifying whether a drug lag exists in the mature markets of the US, EU and Japan. This work focuses on the emerging markets because of the potential they hold for the future of the pharmaceutical industry as a consequence of rapid economic and political development. The aims of this work are to ascertain whether a drug lag exists in the emerging markets and how it has changed over time from the 1960s to the 2000s. It will also highlight key regulatory barriers which may contribute to drug lag. The date of the marketing authorisation (MA) approval by the US Food and Drug Administration (FDA) was used as a reference point. A comparison against the company database regarding emerging market specific approval enabled the difference in time and thus the drug lag for that particular market to be calculated. This work concludes that the overall relative drug lag in the emerging markets has decreased over time and that there are seven key regulatory barriers which need to be targeted in order to make further improvements; ‘Western Approval’, local clinical development (LCD), Certificate of Pharmaceutical Product (CPP), Good Manufacturing Practice (GMP), pricing approval, document authentication and harmonisation. PMID:21829782

  16. Accounting Profession: Oversight, Auditor Independence, and Financial Reporting Issues

    DTIC Science & Technology

    2002-05-03

    oversight of the accounting profession, auditor independence, and selected financial reporting matters. The sudden and largely unexpected bankruptcy of the...Enron Corporation (Enron) and other large corporations financial reporting restatements have raised questions about the soundness of the current self...regulatory and financial reporting systems and resulted in substantial losses to employees, shareholders, and other investors. These events have also

  17. Flap-Lag-Torsion Stability in Forward Flight

    NASA Technical Reports Server (NTRS)

    Panda, B.; Chopra, I.

    1985-01-01

    An aeroelastic stability of three-degree flap-lag-torsion blade in forward flight is examined. Quasisteady aerodynamics with a dynamic inflow model is used. The nonlinear time dependent periodic blade response is calculated using an iterative procedure based on Floquet theory. The periodic perturbation equations are solved for stability using Floquet transition matrix theory as well as constant coefficient approximation in the fixed reference frame. Results are presented for both stiff-inplane and soft-inplane blade configurations. The effects of several parameters on blade stability are examined, including structural coupling, pitch-flap and pitch-lag coupling, torsion stiffness, steady inflow distribution, dynamic inflow, blade response solution and constant coefficient approximation.

  18. Information-theoretic approach to lead-lag effect on financial markets

    NASA Astrophysics Data System (ADS)

    Fiedor, Paweł

    2014-08-01

    Recently the interest of researchers has shifted from the analysis of synchronous relationships of financial instruments to the analysis of more meaningful asynchronous relationships. Both types of analysis are concentrated mostly on Pearson's correlation coefficient and consequently intraday lead-lag relationships (where one of the variables in a pair is time-lagged) are also associated with them. Under the Efficient-Market Hypothesis such relationships are not possible as all information is embedded in the prices, but in real markets we find such dependencies. In this paper we analyse lead-lag relationships of financial instruments and extend known methodology by using mutual information instead of Pearson's correlation coefficient. Mutual information is not only a more general measure, sensitive to non-linear dependencies, but also can lead to a simpler procedure of statistical validation of links between financial instruments. We analyse lagged relationships using New York Stock Exchange 100 data not only on an intraday level, but also for daily stock returns, which have usually been ignored.

  19. 14 CFR 1-1 - Applicability of system of accounts and reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Applicability of system of accounts and reports. Sec. 1-1 Section Sec. 1-1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-1 Applicability of system of accounts and...

  20. Confounders of mutation-rate estimators: selection and phenotypic lag in Thermus thermophilus

    PubMed Central

    Kissling, Grace E.; Grogan, Dennis W.; Drake, John W.

    2015-01-01

    In a recent description of the rate and character of spontaneous mutation in the hyperthermophilic bacterium Thermus thermophilus, the mutation rate was observed to be substantially lower than seen in several mesophiles. Subsequently, a report appeared indicating that this bacterium maintains an average of about 4.5 genomes per cell. This number of genomes might result in a segregation lag for the expression of a recessive mutation and might therefore lead to an underestimate of the rate of mutation. Here we describe some kinds of problems that may arise when estimating mutation rates and outline ways to adjust the rates accordingly. The emphasis is mainly on differential rates of growth of mutants versus their parents and on various kinds of phenotypic lag. We then apply these methods to the T. thermophilus data and conclude that there is as yet no reliable impact on a previously described rate. PMID:23916418

  1. Clinical introduction of image lag correction for a cone beam CT system.

    PubMed

    Stankovic, Uros; Ploeger, Lennert S; Sonke, Jan-Jakob; van Herk, Marcel

    2016-03-01

    Image lag in the flat-panel detector used for Linac integrated cone beam computed tomography (CBCT) has a degrading effect on CBCT image quality. The most prominent visible artifact is the presence of bright semicircular structure in the transverse view of the scans, known also as radar artifact. Several correction strategies have been proposed, but until now the clinical introduction of such corrections remains unreported. In November 2013, the authors have clinically implemented a previously proposed image lag correction on all of their machines at their main site in Amsterdam. The purpose of this study was to retrospectively evaluate the effect of the correction on the quality of CBCT images and evaluate the required calibration frequency. Image lag was measured in five clinical CBCT systems (Elekta Synergy 4.6) using an in-house developed beam interrupting device that stops the x-ray beam midway through the data acquisition of an unattenuated beam for calibration. A triple exponential falling edge response was fitted to the measured data and used to correct image lag from projection images with an infinite response. This filter, including an extrapolation for saturated pixels, was incorporated in the authors' in-house developed clinical cbct reconstruction software. To investigate the short-term stability of the lag and associated parameters, a series of five image lag measurement over a period of three months was performed. For quantitative analysis, the authors have retrospectively selected ten patients treated in the pelvic region. The apparent contrast was quantified in polar coordinates for scans reconstructed using the parameters obtained from different dates with and without saturation handling. Visually, the radar artifact was minimal in scans reconstructed using image lag correction especially when saturation handling was used. In patient imaging, there was a significant reduction of the apparent contrast from 43 ± 16.7 to 15.5 ± 11.9 HU without the

  2. Clinical introduction of image lag correction for a cone beam CT system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stankovic, Uros; Ploeger, Lennert S.; Sonke, Jan-Jakob, E-mail: j.sonke@nki.nl

    Purpose: Image lag in the flat-panel detector used for Linac integrated cone beam computed tomography (CBCT) has a degrading effect on CBCT image quality. The most prominent visible artifact is the presence of bright semicircular structure in the transverse view of the scans, known also as radar artifact. Several correction strategies have been proposed, but until now the clinical introduction of such corrections remains unreported. In November 2013, the authors have clinically implemented a previously proposed image lag correction on all of their machines at their main site in Amsterdam. The purpose of this study was to retrospectively evaluate themore » effect of the correction on the quality of CBCT images and evaluate the required calibration frequency. Methods: Image lag was measured in five clinical CBCT systems (Elekta Synergy 4.6) using an in-house developed beam interrupting device that stops the x-ray beam midway through the data acquisition of an unattenuated beam for calibration. A triple exponential falling edge response was fitted to the measured data and used to correct image lag from projection images with an infinite response. This filter, including an extrapolation for saturated pixels, was incorporated in the authors’ in-house developed clinical CBCT reconstruction software. To investigate the short-term stability of the lag and associated parameters, a series of five image lag measurement over a period of three months was performed. For quantitative analysis, the authors have retrospectively selected ten patients treated in the pelvic region. The apparent contrast was quantified in polar coordinates for scans reconstructed using the parameters obtained from different dates with and without saturation handling. Results: Visually, the radar artifact was minimal in scans reconstructed using image lag correction especially when saturation handling was used. In patient imaging, there was a significant reduction of the apparent contrast from 43

  3. Government Accountability Reports and Public Education Policy: Studying Political Actors' Decision-Making

    ERIC Educational Resources Information Center

    Salazar, Timothy Ross

    2013-01-01

    This study asks how government accountability reports are used to influence public education policy. Government accountability reports, called "audits" in Utah, prove to be useful tools for examining education policy. Using a collective case study design examining Utah's Class Size Reduction (CSR) policy, government accountability…

  4. A novel sliding mode guidance law without line-of-sight angular rate information accounting for autopilot lag

    NASA Astrophysics Data System (ADS)

    He, Shaoming; Wang, Jiang; Wang, Wei

    2017-12-01

    This paper proposes a new composite guidance law to intercept manoeuvring targets without line-of-sight (LOS) angular rate information in the presence of autopilot lag. The presented formulation is obtained via a combination of homogeneous theory and sliding mode control approach. Different from some existing observers, the proposed homogeneous observer can estimate the lumped uncertainty and the LOS angular rate in an integrated manner. To reject the mismatched lumped uncertainty in the integrated guidance and autopilot system, a sliding surface, which consists of the system states and the estimated states, is proposed and a robust guidance law is then synthesised. Stability analysis shows that the LOS angular rate can be stabilised in a small region around zero asymptotically and the upper bound can be lowered by appropriate parameter choice. Numerical simulations with some comparisons are carried out to demonstrate the superiority of the proposed method.

  5. 14 CFR Sec. 1-2 - Waivers from this system of accounts and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED... the principles embodied in the provisions of this system of accounts and reports; and the application...

  6. 31 CFR 103.24 - Reports of foreign financial accounts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., a bank, securities or other financial account in a foreign country shall report such relationship to the Commissioner of the Internal Revenue for each year in which such relationship exists, and shall provide such information as shall be specified in a reporting form prescribed by the Secretary to be filed...

  7. Granular resistive force theory explains the neuromechanical phase lag during sand-swimming

    NASA Astrophysics Data System (ADS)

    Ding, Yang; Sharpe, Sarah; Goldman, Daniel

    2012-11-01

    Undulatory locomotion is a common gait used by a diversity of animals in a range of environments. This mode of locomotion is characterized by the propagation of a traveling wave of body bending, which propels the animal in the opposite direction of the wave. Previous studies of undulatory locomotion in fluids, on land, and even within sand revealed that the wave of muscle activation progresses faster than the traveling wave of curvature. This leads to an increasing phase lag between activation and curvature at more posterior segments, known as the neuromechanical phase lag. In this study, we compare biological measurements of phase lag during the sand-swimming of the sandfish lizard to predictions of a simple model of undulatory swimming that consists of prescribed kinematics and granular resistive forces. The neuromechanical phase lag measured using electromyography (EMG) quantitatively matches the predicted phase lag between the local body curvature and torque exerted by granular resistive forces. Two effects are responsible for the phase lag in this system: the yaw motion of the body and different integration length over a traveling force pattern for different positions along the body.

  8. The nature of delayed dream incorporation ('dream-lag effect'): Personally significant events persist, but not major daily activities or concerns.

    PubMed

    Eichenlaub, Jean-Baptiste; van Rijn, Elaine; Phelan, Mairéad; Ryder, Larnia; Gaskell, M Gareth; Lewis, Penelope A; P Walker, Matthew; Blagrove, Mark

    2018-04-22

    Incorporation of details from waking life events into rapid eye movement (REM) sleep dreams has been found to be highest on the 2 nights after, and then 5-7 nights after, the event. These are termed, respectively, the day-residue and dream-lag effects. This study is the first to categorize types of waking life experiences and compare their incorporation into dreams across multiple successive nights. Thirty-eight participants completed a daily diary each evening and a dream diary each morning for 14 days. In the daily diary, three categories of experiences were reported: major daily activities (MDAs), personally significant events (PSEs) and major concerns (MCs). After the 14-day period each participant identified the correspondence between items in their daily diaries and subsequent dream reports. The day-residue and dream-lag effects were found for the incorporation of PSEs into dreams (effect sizes of .33 and .27, respectively), but only for participants (n = 19) who had a below-median total number of correspondences between daily diary items and dream reports (termed "low-incorporators" as opposed to "high-incorporators"). Neither the day-residue or dream-lag effects were found for MDAs or MCs. This U-shaped timescale of incorporation of events from daily life into dreams has been proposed to reflect REM sleep-dependent memory consolidation, possibly related to emotional memory processing. This study had a larger sample size of dreams than any dream-lag study hitherto with trained participants. Coupled with previous successful replications, there is thus substantial evidence supporting the dream-lag effect and further explorations of its mechanism, including its neural underpinnings, are warranted. © 2018 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.

  9. SOFT LAGS IN NEUTRON STAR kHz QUASI-PERIODIC OSCILLATIONS: EVIDENCE FOR REVERBERATION?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barret, Didier, E-mail: didier.barret@irap.omp.eu; CNRS, Institut de Recherche en Astrophysique et Planetologie, 9 Av. colonel Roche, BP 44346, F-31028 Toulouse cedex 4

    2013-06-10

    High frequency soft reverberation lags have now been detected from stellar mass and supermassive black holes. Their interpretation involves reflection of a hard source of photons onto an accretion disk, producing a delayed reflected emission, with a time lag consistent with the light travel time between the irradiating source and the disk. Independently of the location of the clock, the kHz quasi-periodic oscillation (QPO) emission is thought to arise from the neutron star boundary layer. Here, we search for the signature of reverberation of the kHz QPO emission, by measuring the soft lags and the lag energy spectrum of themore » lower kHz QPOs from 4U1608-522. Soft lags, ranging from {approx}15 to {approx}40 {mu}s, between the 3-8 keV and 8-30 keV modulated emissions are detected between 565 and 890 Hz. The soft lags are not constant with frequency and show a smooth decrease between 680 Hz and 890 Hz. The broad band X-ray spectrum is modeled as the sum of a disk and a thermal Comptonized component, plus a broad iron line, expected from reflection. The spectral parameters follow a smooth relationship with the QPO frequency, in particular the fitted inner disk radius decreases steadily with frequency. Both the bump around the iron line in the lag energy spectrum and the consistency between the lag changes and the inferred changes of the inner disk radius, from either spectral fitting or the QPO frequency, suggest that the soft lags may indeed involve reverberation of the hard pulsating QPO source on the disk.« less

  10. Time-lagged response of the Antarctic atmosphere to tropical MJO convection

    NASA Astrophysics Data System (ADS)

    Henderson, G. R.; Barrett, B.

    2017-12-01

    Intraseasonal tropical climate variability has important implications on mid- and high- latitude climate, and in recent studies has been shown to modulate a number of weather processes in the Northern Hemisphere, such as snow depth, sea ice concentration, precipitation, atmospheric rivers, and air temperature. In such studies, the leading mode of tropical intraseasonal variability, the Madden-Julian Oscillation (MJO), has tended to lag tropical convection by approximately 7 days. However, no such consensus exists when considering the relationship and lag between the MJO and the Antarctic atmosphere. This study builds on previous work by further examining the time-lagged response of Southern Hemisphere tropospheric circulation to tropical MJO forcing, with specific focus on the latitude belt associated with the Antarctic Oscillation, during the months of June (Austral winter) and December (Austral summer) using NCEP-DOE Reanalysis 2 data for the years 1970-2016. Principal findings indicate that the time lag with strongest height anomalies depends on both the location of the MJO convection (e.g., the MJO phase) and the season, and that the lagged height anomalies in the Antarctic atmosphere are fairly consistent across different vertical levels and latitudinal bands. In addition, certain MJO phases in December displayed lagged height anomalies indicative of blocking-type atmospheric patterns, with an approximate wavenumber of 4, whereas in June most phases were associated with progressive height anomaly centers displaying a wavenumber-3 type pattern.

  11. LagLoc - a new surgical technique for locking plate systems.

    PubMed

    Triana, Miguel; Gueorguiev, Boyko; Sommer, Christoph; Stoffel, Karl; Agarwal, Yash; Zderic, Ivan; Helfen, Tobias; Krieg, James C; Krause, Fabian; Knobe, Matthias; Richards, R Geoff; Lenz, Mark

    2018-06-19

    Treatment of oblique and spiral fractures remains challenging. The aim of this study was to introduce and investigate the new LagLoc technique for locked plating with generation of interfragmentary compression, combining the advantages of lag-screw and locking-head-screw techniques. Oblique fracture was simulated in artificial diaphyseal bones, assigned to three groups for plating with a 7-hole locking compression plate. Group I was plated with three locking screws in holes 1, 4 and 7. The central screw crossed the fracture line. In group II the central hole was occupied with a lag screw perpendicular to fracture line. Group III was instrumented applying the LagLoc technique as follows. Hole 4 was predrilled perpendicularly to the plate, followed by overdrilling of the near cortex and insertion of a locking screw whose head was covered by a holding sleeve to prevent temporarily the locking in the plate hole and generate interfragmentary compression. Subsequently, the screw head was released and locked in the plate hole. Holes 1 and 7 were occupied with locking screws. Interfragmentary compression in the fracture gap was measured using pressure sensors. All screws in the three groups were tightened with 4Nm torque. Interfragmentary compression in group I (167 ± 25N) was significantly lower in comparison to groups II (431 ± 21N) and III (379 ± 59N), p≤0.005. The difference in compression between groups II and III remained not significant (p = 0.999). The new LagLoc technique offers an alternative tool to generate interfragmentary compression with the application of locking plates by combining the biomechanical advantages of lag screw and locking screw fixations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Time lag and communication in changing unpopular norms.

    PubMed

    Gërxhani, Klarita; Bruggeman, Jeroen

    2015-01-01

    Humans often coordinate their social lives through norms. When a large majority of people are dissatisfied with an existing norm, it seems obvious that they will change it. Often, however, this does not occur. We investigate how a time lag between individual support of a norm change and the change itself hinders such change, related to the critical mass of supporters needed to effectuate the change, and the (im)possibility of communicating about it. To isolate these factors, we utilize a laboratory experiment. As predicted, we find unambiguous effects of time lag on precluding norm change; a higher threshold for a critical mass does so as well. Communication facilitates choosing superior norms but it does not necessarily lead to norm change when the uncertainty on whether there will be a norm change in the future is high. Communication seems to help coordination on actions at the present but not the future. Hence, the uncertainty driven by time lag makes individuals choose the status quo, here the unpopular norm.

  13. Time Lag and Communication in Changing Unpopular Norms

    PubMed Central

    Gërxhani, Klarita; Bruggeman, Jeroen

    2015-01-01

    Humans often coordinate their social lives through norms. When a large majority of people are dissatisfied with an existing norm, it seems obvious that they will change it. Often, however, this does not occur. We investigate how a time lag between individual support of a norm change and the change itself hinders such change, related to the critical mass of supporters needed to effectuate the change, and the (im)possibility of communicating about it. To isolate these factors, we utilize a laboratory experiment. As predicted, we find unambiguous effects of time lag on precluding norm change; a higher threshold for a critical mass does so as well. Communication facilitates choosing superior norms but it does not necessarily lead to norm change when the uncertainty on whether there will be a norm change in the future is high. Communication seems to help coordination on actions at the present but not the future. Hence, the uncertainty driven by time lag makes individuals choose the status quo, here the unpopular norm. PMID:25880200

  14. Shear-lag analysis about an internally-dropped ply

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vizzini, A.J.

    1995-12-31

    The region around a terminated ply is modeled as several elastic layers separated by shear regions. A shear-lag analysis is then performed allowing for the thickness of the elastic and shear layers to vary. Boundary conditions, away for the ply drop, are based on the deflections determined by a finite element model. The interlaminar stresses are compared against those generated by the finite element model for tapered laminates under pure extension, pure bending, and extension-bending coupling. The shear-lag analysis predicts the interlaminar shear at and near the ply drop for pure extension and in cases involving bending if the deflectionsmore » due to bending are removed. The interlaminar shear stress and force equilibrium are used to determine the interlaminar normal stress. The trends in the interlaminar normal stress shown by the finite element model are partially captured by the shear-lag analysis. This simple analysis indicates that the mechanism for load transfer about a ply drop is primarily due to shear transfer through the resin rich areas.« less

  15. An evaluation of the lag of accommodation using photorefraction.

    PubMed

    Seidemann, Anne; Schaeffel, Frank

    2003-02-01

    The lag of accommodation which occurs in most human subjects during reading has been proposed to explain the association between reading and myopia. However, the measured lags are variable among different published studies and current knowledge on its magnitude rests largely on measurements with the Canon R-1 autorefractor. Therefore, we have measured it with another technique, eccentric infrared photorefraction (the PowerRefractor), and studied how it can be modified. Particular care was taken to ensure correct calibration of the instrument. Ten young adult subjects were refracted both in the fixation axis of the right eye and from the midline between both eyes, while they read text both monocularly and binocularly at 1.5, 2, 3, 4 and 5 D distance ("group 1"). A second group of 10 subjects ("group 2"), measured from the midline between both eyes, was studied to analyze the effects of binocular vs monocular vision, addition of +1 or +2 D lenses, and of letter size. Spherical equivalents (SE) were analyzed in all cases. The lag of accommodation was variable among subjects (standard deviations among groups and viewing distances ranging from 0.18 to 1.07 D) but was significant when the measurements were done in the fixation axis (0.35 D at 3 D target distance to 0.60 D at 5 D with binocular vision; p<0.01 or better all cases). Refracting from the midline between both eyes tended to underestimate the lag of accommodation although this was significant only at 5 D (ANOVA: p<0.0001, post hoc t-test: p<0.05). There was a small improvement in accommodation precision with binocular compared to monocular viewing but significance was reached only for the 5 D reading target (group 1--lags for a 3/4/5 D target: 0.35 vs 0.41 D/0.48 vs 0.47 D/0.60 vs 0.66 D, ANOVA: p<0.0001, post hoc t-test: p<0.05; group 2--0.29 vs 0.12 D, 0.33 vs 0.16 D, 0.23 vs -0.31 D, ANOVA: p<0.0001, post hoc t-test: p<0.05). Adjusting the letter height for constant angular subtense (0.2 deg) induced

  16. 14 CFR Sec. 1-3 - General description of system of accounts and reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false General description of system of accounts and reports. Sec. 1-3 Section 1-3 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... reports. (a) This system of accounts and reports is designed to permit limited contraction or expansion to...

  17. 14 CFR Sec. 1-3 - General description of system of accounts and reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false General description of system of accounts and reports. Sec. 1-3 Section 1-3 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... reports. (a) This system of accounts and reports is designed to permit limited contraction or expansion to...

  18. 14 CFR Sec. 1-3 - General description of system of accounts and reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false General description of system of accounts and reports. Sec. 1-3 Section 1-3 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... reports. (a) This system of accounts and reports is designed to permit limited contraction or expansion to...

  19. Avulsion Fracture of the Calcaneus Treated With a Soft Anchor Bridge and Lag Screw Technique: A Report of Two Cases.

    PubMed

    Yoshida, Kazushige; Kasama, Kentaro; Akahane, Tsutomu

    2016-01-01

    The displaced extra-articular avulsion fracture of the calcaneus has been classified as a Böhler type 1c calcaneal fracture, and most cases will require surgical repair. In the present report, we describe 2 patients in whom we performed the soft anchor bridge technique using single loaded suture anchors with lag screws for the repair of Böhler type 1c avulsion fractures of the calcaneus. In one of these patients, clinically relevant osteoporosis complicated the injury. In both cases, bone union was achieved, and by 1.5 months after surgery satisfactory recovery was observed. To our knowledge, the soft anchor bridge technique was first used for the treatment of rotator cuff tears, and the greatest merit of this technique is the ability to generate vertical compression force to the pulled out rotator cuff through the use of knotting sutures. In recent years, the soft anchor bridge technique using 4 suture anchors has also been used for fractures of the greater tuberosity of the humerus, an injury that poses operative difficulties similar to those encountered with an avulsion fracture of the calcaneus owing to the traction force of the rotator cuff and relative weakness of adjacent bone. The outcomes of our patients suggest that the soft anchor bridge technique combined with adjunct lag screws is useful in the fixation of avulsion fractures of the calcaneus. In addition, the result in the elderly patient indicates the possibility of using this technique for patients with osteoporosis. Copyright © 2016 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

  20. Accommodative Lag by Autorefraction and Two Dynamic Retinoscopy Methods

    PubMed Central

    2008-01-01

    Purpose To evaluate two clinical procedures, MEM and Nott retinoscopy, for detecting accommodative lags 1.00 diopter (D) or greater in children as identified by an open-field autorefractor. Methods 168 children 8 to <12 years old with low myopia, normal visual acuity, and no strabismus participated as part of an ancillary study within the screening process for a randomized trial. Accommodative response to a 3.00 D demand was first assessed by MEM and Nott retinoscopy, viewing binocularly with spherocylindrical refractive error corrected, with testing order randomized and each performed by a different masked examiner. The response was then determined viewing monocularly with spherical equivalent refractive error corrected, using an open-field autorefractor, which was the gold standard used for eligibility for the clinical trial. Sensitivity and specificity for accommodative lags of 1.00 D or more were calculated for each retinoscopy method compared to the autorefractor. Results 116 (69%) of the 168 children had accommodative lag of 1.00 D or more by autorefraction. MEM identified 66 children identified by autorefraction for a sensitivity of 57% (95% CI = 47% to 66%) and a specificity of 63% (95% CI = 49% to 76%). Nott retinoscopy identified 35 children for a sensitivity of 30% (95% CI = 22% to 39%) and a specificity of 81% (95% CI = 67% to 90%). Analysis of receiver operating characteristic (ROC) curves constructed for MEM and for Nott retinoscopy failed to reveal alternate cut points that would improve the combination of sensitivity and specificity for identifying accommodative lag ≥ 1.00 D as defined by autorefraction. Conclusions Neither MEM nor Nott retinoscopy provided adequate sensitivity and specificity to identify myopic children with accommodative lag ≥ 1.00 D as determined by autorefraction. A variety of methodological differences between the techniques may contribute to the modest to poor agreement. PMID:19214130

  1. Circadian rhythms, athletic performance, and jet lag

    PubMed Central

    Manfredini, R.; Manfredini, F.; Fersini, C.; Conconi, F.

    1998-01-01

    Rapid air travel across several time zones exposes the traveller to a shift in his/her internal biological clock. The result is a transient desynchronisation of the circadian rhythm, called jet lag, lasting until the rhythm is rephased to the new environmental conditions. The most commonly experienced symptoms are sleep disorders, difficulties with concentrating, irritability, depression, fatigue, disorientation, loss of appetite, and gastrointestinal disturbance. Apart from the decrements in mental and physical performance directly consequent on such symptoms, competitive athletes are also exposed to the additional negative consequences of a shift from the optimal circadian window of performance. A brief summary of the possible negative effects of jet lag on athletic performance and potentially alleviating strategies is given. 




 PMID:9631214

  2. 49 CFR 230.64 - Leaks under lagging.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Leaks § 230.64 Leaks under lagging. The steam locomotive owner and/or operator shall take out of...

  3. Aeromechanical stability augmentation using semi-active friction-based lead-lag damper

    NASA Astrophysics Data System (ADS)

    Agarwal, Sandeep

    2005-11-01

    Lead-lag dampers are present in most rotors to provide the required level of damping in all flight conditions. These dampers are a critical component of the rotor system, but they also represent a major source of maintenance cost. In present rotor systems, both hydraulic and elastomeric lead-lag dampers have been used. Hydraulic dampers are complex mechanical components that require hydraulic fluids and have high associated maintenance costs. Elastomeric dampers are conceptually simpler and provide a "dry" rotor, but are rather costly. Furthermore, their damping characteristics can degrade with time without showing external signs of failure. Hence, the dampers must be replaced on a regular basis. A semi-active friction based lead-lag damper is proposed as a replacement for hydraulic and elastomeric dampers. Damping is provided by optimized energy dissipation due to frictional forces in semi-active joints. An actuator in the joint modulates the normal force that controls energy dissipation at the frictional interfaces, resulting in large hysteretic loops. Various selective damping strategies are developed and tested for a simple system containing two different frequency modes in its response, one of which needs to be damped out. The system reflects the situation encountered in rotor response where 1P excitation is present along with the potentially unstable regressive lag motion. Simulation of the system response is obtained to compare their effectiveness. Next, a control law governing the actuation in the lag damper is designed to generate the desired level of damping for performing adaptive selective damping of individual blade lag motion. Further, conceptual design of a piezoelectric friction based lag damper for a full-scale rotor is presented and various factors affecting size, design and maintenance cost, damping capacity, and power requirements of the damper are discussed. The selective semi-active damping strategy is then studied in the context of classical

  4. 29 CFR 2520.104-50 - Short plan years, deferral of accountant's examination and report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Short plan years, deferral of accountant's examination and... Reporting and Disclosure Requirements § 2520.104-50 Short plan years, deferral of accountant's examination... year begins is changed. (b) Deferral of accountant's report. A plan administrator is not required to...

  5. 29 CFR 2520.104-50 - Short plan years, deferral of accountant's examination and report.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Short plan years, deferral of accountant's examination and... Reporting and Disclosure Requirements § 2520.104-50 Short plan years, deferral of accountant's examination... year begins is changed. (b) Deferral of accountant's report. A plan administrator is not required to...

  6. 29 CFR 2520.104-50 - Short plan years, deferral of accountant's examination and report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Short plan years, deferral of accountant's examination and... Reporting and Disclosure Requirements § 2520.104-50 Short plan years, deferral of accountant's examination... year begins is changed. (b) Deferral of accountant's report. A plan administrator is not required to...

  7. 29 CFR 2520.104-50 - Short plan years, deferral of accountant's examination and report.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Short plan years, deferral of accountant's examination and... Reporting and Disclosure Requirements § 2520.104-50 Short plan years, deferral of accountant's examination... year begins is changed. (b) Deferral of accountant's report. A plan administrator is not required to...

  8. Lead-Lag Control for Helicopter Vibration and Noise Reduction

    NASA Technical Reports Server (NTRS)

    Gandhi, Farhan

    1995-01-01

    . Both schemes cause an increase in pitch link loads. Trailing Edge Flap (TEF) deployment can also used to generate unsteady aerodynamic forces and moments that counter the original vibratory loads, and thereby reduce rotor vibrations. While the vibrations absorbers, HHC, IBC, and TEF concepts discussed above attempt to reduce the vibratory loads, they do not specifically address the phenomena causing the vibrations at high advance ratios. One passive method that attempts to directly alleviate compressibility and stall, instead of reducing the ensuing vibrations, is the use of advanced tip designs. Taper, sweep, anhedral, and the manipulation of other geometric properties of the blade tips can reduce the severity of stall and compressibility effects , as well as reduce rotor power. A completely different approach to solve these problems is the tiltrotor configuration. As the forward velocity of the aircraft increases, the rotors, in this case, are tilted forward until they are perpendicular to the flow and act as propellers. This eliminates the edgewise flow encountered by conventional rotors and circumvents all the problems associated with flow asymmetry. However, the success involves a tremendous increase in cost and complexity of the aircraft. Another possible approach that has been proposed for the alleviation of vibratory loads at high forward flight speeds involves the use of controlled lead-lag motions to reduce the asymmetry in flow. A correctly phased 1/rev controlled lag motion could be introduced such that it produces a backward velocity on the advancing side and a forward velocity on the retreating side, to delay compressibility effects and stall to a higher advance ratio. Using a large enough lead-lag amplitude, the tip velocities could be reduced to levels encountered in hover. This concept was examined by two groups in the 1950's and early 1960's. In the United States, the Research Labs Division of United Aircraft developed a large lead-lag motion rotor

  9. Influence of several factors on ignition lag in a compression-ignition engine

    NASA Technical Reports Server (NTRS)

    Gerrish, Harold C; Voss, Fred

    1932-01-01

    This investigation was made to determine the influence of fuel quality, injection advance angle, injection valve-opening pressure, inlet-air pressure, compression ratio, and engine speed on the time lag of auto-ignition of a Diesel fuel oil in a single-cylinder compression-ignition engine as obtained from an analysis of indicator diagrams. Three cam-operated fuel-injection pumps, two pumps cams, and an automatic injection valve with two different nozzles were used. Ignition lag was considered to be the interval between the start of injection of the fuel as determined with a Stroborama and the start of effective combustion as determined from the indicator diagram, the latter being the point where 4.0 x 10(exp-6) pound of fuel had been effectively burned. For this particular engine and fuel it was found that: (1) for a constant start and the same rate of fuel injection up the point of cut-off, a variation in fuel quantity from 1.2 x 10(exp-4) to 4.1 x 10(exp-4) pound per cycle has no appreciable effect on the ignition lag; (2) injection advance angle increases or decreases the lag according to whether density, temperature, or turbulence has the controlling influence; (3) increase in valve-opening pressure slightly increases the lag; and (4) increase of inlet-air pressure, compression ratio, and engine speed reduces the lag.

  10. 76 FR 10234 - Amendment to the Bank Secrecy Act Regulations-Reports of Foreign Financial Accounts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ...FinCEN is issuing this final rule to amend the Bank Secrecy Act (BSA) regulations regarding reports of foreign financial accounts. The rule addresses the scope of the persons that are required to file reports of foreign financial accounts. The rule further specifies the types of accounts that are reportable, and provides filing relief in the form of exemptions for certain persons with signature or other authority over foreign financial accounts. Finally, the rule adopts provisions intended to prevent persons subject to the rule from avoiding their reporting requirement.

  11. Constraining Anisotropic Lorentz Violation via the Spectral-lag Transition of GRB 160625B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wei, Jun-Jie; Wu, Xue-Feng; Shao, Lang

    Violations of Lorentz invariance can lead to an energy-dependent vacuum dispersion of light, which results in arrival-time differences of photons with different energies arising from a given transient source. In this work, direction-dependent dispersion constraints are obtained on nonbirefringent Lorentz-violating effects using the observed spectral lags of the gamma-ray burst GRB 160625B. This burst has unusually large high-energy photon statistics, so we can obtain constraints from the true spectral time lags of bunches of high-energy photons rather than from the rough time lag of a single highest-energy photon. Also, GRB 160625B is the only burst to date having a well-definedmore » transition from positive lags to negative lags, providing a unique opportunity to distinguish Lorentz-violating effects from any source-intrinsic time lag in the emission of photons of different energy bands. Our results place comparatively robust two-sided constraints on a variety of isotropic and anisotropic coefficients for Lorentz violation, including the first bounds on Lorentz-violating effects from operators of mass dimension 10 in the photon sector.« less

  12. The effect of control and display lag on unmanned air system internal pilot manual landing performance

    NASA Astrophysics Data System (ADS)

    Lloyd, Marshall Everett

    An important characteristic of UASs is lag because it can become a considerable challenge to successful human-in-the-loop control. As such, UASs are designed and configured to minimize system lag, though this can increase acquisition and operation costs considerably. In an effort to cut costs, an organization may choose to accept greater risk and deploy a UAS with high system lag. Before this risk can be responsibly accepted, it must be quantified. While many studies have examined system lag, very few have been able to quantify the risk that various levels of lag pose to an internally piloted, manually landed UAS. This study attempted to do so by evaluating pilot landing performance in a simulator with 0 ms, 240 ms, and 1000 ms of additional lag. Various measures were used, including a novel coding technique. Results indicated that 1000 ms of lag was unsafe by all measures. They also indicate that 240 ms of lag degrades performance, but participants were able to successfully land the simulated aircraft. This study showed the utility of using several measures to evaluate the effect of lag on landing performance and it helped demonstrate that while 1000 ms poses a high risk, 240 ms of lag may be a much more manageable risk. Future research suggested by this research includes: investigating lag between 240 ms and 1000 ms, introducing different weather phenomena, developing system lag training techniques for operators, and investigating the effect of aides such as predictive displays and autopilot-assisted recovery.

  13. AN INVESTIGATION OF TIME LAG MAPS USING THREE-DIMENSIONAL SIMULATIONS OF HIGHLY STRATIFIED HEATING

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Winebarger, Amy R.; Lionello, Roberto; Downs, Cooper

    2016-11-10

    The location and frequency of coronal energy release provide a significant constraint on the coronal heating mechanism. The evolution of the intensity observed in coronal structures found from time lag analysis of Atmospheric Imaging Assembly (AIA) data has been used to argue that heating must occur sporadically. Recently, we have demonstrated that quasi-steady, highly stratified (footpoint) heating can produce results qualitatively consistent with the evolution of observed coronal structures. The goals of this paper are to demonstrate that time lag analysis of 3D simulations of footpoint heating are qualitatively consistent with time lag analysis of observations and to use themore » 3D simulations to further understand whether time lag analysis is a useful tool in defining the evolution of coronal structures. We find the time lag maps generated from simulated data are consistent with the observed time lag maps. We next investigate several example points. In some cases, the calculated time lag reflects the evolution of a unique loop along the line of sight, though there may be additional evolving structures along the line of sight. We confirm that using the multi-peak AIA channels can produce time lags that are difficult to interpret. We suggest using a different high temperature channel, such as an X-ray channel. Finally, we find that multiple evolving structures along the line of sight can produce time lags that do not represent the physical properties of any structure along the line of sight, although the cross-correlation coefficient of the lightcurves is high. Considering the projected geometry of the loops may reduce some of the line-of-sight confusion.« less

  14. 46 CFR 98.25-30 - Lagging.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

  15. 46 CFR 98.25-30 - Lagging.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

  16. 46 CFR 98.25-30 - Lagging.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

  17. 46 CFR 98.25-30 - Lagging.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

  18. 46 CFR 98.25-30 - Lagging.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

  19. Modeling eye gaze patterns in clinician-patient interaction with lag sequential analysis.

    PubMed

    Montague, Enid; Xu, Jie; Chen, Ping-Yu; Asan, Onur; Barrett, Bruce P; Chewning, Betty

    2011-10-01

    The aim of this study was to examine whether lag sequential analysis could be used to describe eye gaze orientation between clinicians and patients in the medical encounter. This topic is particularly important as new technologies are implemented into multiuser health care settings in which trust is critical and nonverbal cues are integral to achieving trust. This analysis method could lead to design guidelines for technologies and more effective assessments of interventions. Nonverbal communication patterns are important aspects of clinician-patient interactions and may affect patient outcomes. The eye gaze behaviors of clinicians and patients in 110 videotaped medical encounters were analyzed using the lag sequential method to identify significant behavior sequences. Lag sequential analysis included both event-based lag and time-based lag. Results from event-based lag analysis showed that the patient's gaze followed that of the clinician, whereas the clinician's gaze did not follow the patient's. Time-based sequential analysis showed that responses from the patient usually occurred within 2 s after the initial behavior of the clinician. Our data suggest that the clinician's gaze significantly affects the medical encounter but that the converse is not true. Findings from this research have implications for the design of clinical work systems and modeling interactions. Similar research methods could be used to identify different behavior patterns in clinical settings (physical layout, technology, etc.) to facilitate and evaluate clinical work system designs.

  20. Modeling Eye Gaze Patterns in Clinician-Patient Interaction with Lag Sequential Analysis

    PubMed Central

    Montague, E; Xu, J; Asan, O; Chen, P; Chewning, B; Barrett, B

    2011-01-01

    Objective The aim of this study was to examine whether lag-sequential analysis could be used to describe eye gaze orientation between clinicians and patients in the medical encounter. This topic is particularly important as new technologies are implemented into multi-user health care settings where trust is critical and nonverbal cues are integral to achieving trust. This analysis method could lead to design guidelines for technologies and more effective assessments of interventions. Background Nonverbal communication patterns are important aspects of clinician-patient interactions and may impact patient outcomes. Method Eye gaze behaviors of clinicians and patients in 110-videotaped medical encounters were analyzed using the lag-sequential method to identify significant behavior sequences. Lag-sequential analysis included both event-based lag and time-based lag. Results Results from event-based lag analysis showed that the patients’ gaze followed that of clinicians, while clinicians did not follow patients. Time-based sequential analysis showed that responses from the patient usually occurred within two seconds after the initial behavior of the clinician. Conclusion Our data suggest that the clinician’s gaze significantly affects the medical encounter but not the converse. Application Findings from this research have implications for the design of clinical work systems and modeling interactions. Similar research methods could be used to identify different behavior patterns in clinical settings (physical layout, technology, etc.) to facilitate and evaluate clinical work system designs. PMID:22046723

  1. Catchment Legacies and Trajectories: Understanding Time Lags in Catchment Response as a Function of Hydrologic and Biogeochemical Controls

    NASA Astrophysics Data System (ADS)

    Basu, N. B.; Van Meter, K. J.

    2012-12-01

    Increased nutrient loads delivered from watersheds due to agricultural intensification, industrialization, and urbanization have contributed globally to the persistence of large hypoxic zones in inland and coastal waters. Watershed management practices targeting these non-point source pollutants often lead to little or no improvement in water quality, even after extensive implementation of conservation measures or Best Management Practices (BMPs). The lag time between implementation of a conservation measure and resultant water quality benefits has recently been recognized as an important factor in the "apparent" failure of these BMPs. When conservation measures are implemented without explicit consideration of the lag time and with expectations that they will lead to immediate benefits, the resulting failure to meet such expectations can discourage vital restoration efforts. It is therefore important to quantify the lag times associated with watershed management efforts a priori and to implement restoration strategies targeted specifically at minimizing lag times and maximizing restoration benefits. The focus of this research is to develop a framework for understanding the time lags between land-use changes and stream water quality benefits. We hypothesize that such time lags arise from nutrient legacies building over decades of fertilizer application. For nitrogen (N), one can conceptualize this as either hydrologic legacy, in the form of dissolved nitrate that is delayed due to slow groundwater transport, or as biogeochemical legacy, in the form of organic N, possibly in dissolved or readily mineralizable forms. Indeed, mass-balance studies across the Mississippi and Thames river basins indicate the possibility of missing N mass in these landscapes, with inputs being consistently greater than the outputs even when accounting for all possible pathways of nitrogen transformation. Historical soil data within the upper Mississippi River Basin (MRB) indicate that

  2. A new method for determining the optimal lagged ensemble

    PubMed Central

    DelSole, T.; Tippett, M. K.; Pegion, K.

    2017-01-01

    Abstract We propose a general methodology for determining the lagged ensemble that minimizes the mean square forecast error. The MSE of a lagged ensemble is shown to depend only on a quantity called the cross‐lead error covariance matrix, which can be estimated from a short hindcast data set and parameterized in terms of analytic functions of time. The resulting parameterization allows the skill of forecasts to be evaluated for an arbitrary ensemble size and initialization frequency. Remarkably, the parameterization also can estimate the MSE of a burst ensemble simply by taking the limit of an infinitely small interval between initialization times. This methodology is applied to forecasts of the Madden Julian Oscillation (MJO) from version 2 of the Climate Forecast System version 2 (CFSv2). For leads greater than a week, little improvement is found in the MJO forecast skill when ensembles larger than 5 days are used or initializations greater than 4 times per day. We find that if the initialization frequency is too infrequent, important structures of the lagged error covariance matrix are lost. Lastly, we demonstrate that the forecast error at leads ≥10 days can be reduced by optimally weighting the lagged ensemble members. The weights are shown to depend only on the cross‐lead error covariance matrix. While the methodology developed here is applied to CFSv2, the technique can be easily adapted to other forecast systems. PMID:28580050

  3. Does public reporting measure up? Federalism, accountability and child-care policy in Canada.

    PubMed

    Anderson, Lynell; Findlay, Tammy

    2010-01-01

    Governments in Canada have recently been exploring new accountability measures within intergovernmental relations. Public reporting has become the preferred mechanism in a range of policy areas, including early learning and child-care, and the authors assess its effectiveness as an accountability measure. The article is based on their experience with a community capacity-building project that considers the relationship between the public policy, funding and accountability mechanisms under the federal/provincial/territorial agreements related to child-care. The authors argue that in its current form, public reporting has not lived up to its promise of accountability to citizens. This evaluation is based on the standards that governments have set for themselves under the federal/provincial/territorial agreements, as well as guidelines set by the Public Sector Accounting Board, an independent body that develops accounting standards over time through consultation with governments.

  4. LAG-3 Represents a Marker of CD4+ T Cells with Regulatory Activity in Patients with Bone Fracture.

    PubMed

    Wang, Jun; Ti, Yunfan; Wang, Yicun; Guo, Guodong; Jiang, Hui; Chang, Menghan; Qian, Hongbo; Zhao, Jianning; Sun, Guojing

    2018-04-19

    The lymphocyte activation gene 3 (LAG-3) is a CD4 homolog with binding affinity to MHC class II molecules. It is thought that LAG-3 exerts a bimodal function, such that co-ligation of LAG-3 and CD3 could deliver an inhibitory signal in conventional T cells, whereas, on regulatory T cells, LAG-3 expression could promote their inhibitory function. In this study, we investigated the role of LAG-3 expression on CD4 + T cells in patients with long bone fracture. We found that LAG-3 + cells represented approximately 13% of peripheral blood CD4 + T cells on average. Compared to LAG-3 - CD4 + T cells, LAG-3 + CD4 + T cells presented significantly higher Foxp3 and CTLA-4 expression. Directly ex vivo or with TCR stimulation, LAG-3 + CD4 + T cells expressed significantly higher levels of IL-10 and TGF-β than LAG-3 - CD4 + T cells. Interestingly, blocking the LAG-3-MHC class II interaction actually increased the IL-10 expression by LAG-3 + CD4 + T cells. The frequency of LAG-3 + CD4 + T cell was positively correlated with restoration of healthy bone function in long bone fracture patients. These results together suggested that LAG-3 is a marker of CD4 + T cells with regulatory function; at the same time, LAG-3 might have limited the full suppressive potential of Treg cells.

  5. S.T.A.R.S @ Glance (Student Teacher Accountability Reporting System)

    ERIC Educational Resources Information Center

    New Mexico Public Education Department, 2006

    2006-01-01

    This document introduces the Student Teacher Accountability Reporting System (STARS), the educational data collection and reporting model selected by the New Mexico Public Education Department (NMPED) to improve the quality and timeliness of data, analysis, and information in meeting increased reporting and analysis requirements. The STARS model…

  6. Report: Making Better Use of Stringfellow Superfund Special Accounts

    EPA Pesticide Factsheets

    Report #08-P-0196, July 9, 2008. By Fiscal Year 2010, EPA Region 9 could reclassify, or transfer to the Trust Fund, up to $47.8 million in special account funds for the Stringfellow Superfund site, located near Glen Avon, California.

  7. Increased Variability in Tacting under a Lag 3 Schedule of Reinforcement

    ERIC Educational Resources Information Center

    Heldt, Juliane; Schlinger, Henry D., Jr.

    2012-01-01

    Research has shown that variability may be an operant dimension of behavior. One method of reinforcing response variability is to use a lag schedule of reinforcement (Page & Neuringer, 1985). Several studies have shown that a Lag 1 schedule is effective in increasing variable responding with human participants (e.g., Esch, Esch, & Love, 2009; Lee,…

  8. The Lag-Luminosity Relation in the GRB Source-Frame: An Investigation with Swift BAT Bursts

    NASA Technical Reports Server (NTRS)

    Ukwatta, T. N.; Dhuga, K. S.; Stamatikos, M.; Dermer, C. D.; Sakamoto, T.; Sonbas, E.; Parke, W. C.; Maximon, L. C.; Linnemann, J. T.; Bhat, P. N.; hide

    2012-01-01

    Spectral lag, which is defined as the difference in time of arrival of high and low energy photons, is a common feature in Gamma-ray Bursts (GRBs). Previous investigations have shown a correlation between this lag and the isotropic peak luminosity for long duration bursts. However, most of the previous investigations used lags extracted in the observer-frame only. In this work (based on a sample of 43 Swift long GRBs with known redshifts), we present an analysis of the lag-luminosity relation in the GRB source-frame. Our analysis indicates a higher degree of correlation -0.82+/-0.05 (chance probability of approx 5.5 X 10(exp -5) between the spectral lag and the isotropic peak luminosity, L(sub iso), with a best-fit power-law index of -1.2 +/- 0.2, such that L(sub iso) varies as lag(exp -1.2). In addition, there is an anti-correlation between the source-frame spectral lag and the source-frame peak energy of the burst spectrum, E(sub pk)(1 + z).

  9. Yeast multistress resistance and lag-phase characterisation during wine fermentation.

    PubMed

    Ferreira, David; Galeote, Virginie; Sanchez, Isabelle; Legras, Jean-Luc; Ortiz-Julien, Anne; Dequin, Sylvie

    2017-09-01

    Saccharomyces cerevisiae has been used to perform wine fermentation for several millennia due to its endurance and unmatched qualities. Nevertheless, at the moment of inoculation, wine yeasts must cope with specific stress factors that still challenge wine makers by slowing down or compromising the fermentation process. To better assess the role of genetic and environmental factors that govern multistress resistance during the wine fermentation lag phase, we used a factorial plan to characterise the individual and combined impact of relevant stress factors on eight S. cerevisiae and two non-S. cerevisiae wine yeast strains that are currently commercialised. The S. cerevisiae strains are very genetically diverse, belonging to the wine and flor groups, and frequently contain a previously described XVIVIII translocation that confers increased resistance to sulphites. We found that low temperature and osmotic stress substantially affected all strains, promoting considerably extended lag phases. SO2 addition had a partially temperature-dependent effect, whereas low phytosterol and thiamine concentrations impacted the lag phase in a strain-dependent manner. No major synergic effects of multistress were detected. The diversity of lag-phase durations and stress responses observed among wine strains offer new insights to better control this critical step of fermentation. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Considering spatial heterogeneity in the distributed lag non-linear model when analyzing spatiotemporal data.

    PubMed

    Chien, Lung-Chang; Guo, Yuming; Li, Xiao; Yu, Hwa-Lung

    2018-01-01

    The distributed lag non-linear (DLNM) model has been frequently used in time series environmental health research. However, its functionality for assessing spatial heterogeneity is still restricted, especially in analyzing spatiotemporal data. This study proposed a solution to take a spatial function into account in the DLNM, and compared the influence with and without considering spatial heterogeneity in a case study. This research applied the DLNM to investigate non-linear lag effect up to 7 days in a case study about the spatiotemporal impact of fine particulate matter (PM 2.5 ) on preschool children's acute respiratory infection in 41 districts of northern Taiwan during 2005 to 2007. We applied two spatiotemporal methods to impute missing air pollutant data, and included the Markov random fields to analyze district boundary data in the DLNM. When analyzing the original data without a spatial function, the overall PM 2.5 effect accumulated from all lag-specific effects had a slight variation at smaller PM 2.5 measurements, but eventually decreased to relative risk significantly <1 when PM 2.5 increased. While analyzing spatiotemporal imputed data without a spatial function, the overall PM 2.5 effect did not decrease but increased in monotone as PM 2.5 increased over 20 μg/m 3 . After adding a spatial function in the DLNM, spatiotemporal imputed data conducted similar results compared with the overall effect from the original data. Moreover, the spatial function showed a clear and uneven pattern in Taipei, revealing that preschool children living in 31 districts of Taipei were vulnerable to acute respiratory infection. Our findings suggest the necessity of including a spatial function in the DLNM to make a spatiotemporal analysis available and to conduct more reliable and explainable research. This study also revealed the analytical impact if spatial heterogeneity is ignored.

  11. Environmental effects and individual body condition drive seasonal fecundity of rabbits: identifying acute and lagged processes.

    PubMed

    Wells, Konstans; O'Hara, Robert B; Cooke, Brian D; Mutze, Greg J; Prowse, Thomas A A; Fordham, Damien A

    2016-07-01

    The reproduction of many species is determined by seasonally-driven resource supply. But it is difficult to quantify whether the fecundity is sensitive to short- or long-term exposure to environmental conditions such as rainfall that drive resource supply. Using 25 years of data on individual fecundity of European female rabbits, Oryctolagus cuniculus, from semiarid Australia, we investigate the role of individual body condition, rainfall and temperature as drivers of seasonal and long-term and population-level changes in fecundity (breeding probability, ovulation rate, embryo survival). We built distributed lag models in a hierarchical Bayesian framework to account for both immediate and time-lagged effects of climate and other environmental drivers, and possible shifts in reproduction over consecutive seasons. We show that rainfall during summer, when rabbits typically breed only rarely, increased breeding probability immediately and with time lags of up to 10 weeks. However, an earlier onset of the yearly breeding period did not result in more overall reproductive output. Better body condition was associated with an earlier onset of breeding and higher embryo survival. Breeding probability in the main breeding season declined with increased breeding activity in the preceding season and only individuals in good body condition were able to breed late in the season. Higher temperatures reduce breeding success across seasons. We conclude that a better understanding of seasonal dynamics and plasticity (and their interplay) in reproduction will provide crucial insights into how lagomorphs are likely to respond and potentially adapt to the influence of future climate and other environmental change.

  12. Greenhouse gases accounting and reporting for waste management--a South African perspective.

    PubMed

    Friedrich, Elena; Trois, Cristina

    2010-11-01

    This paper investigates how greenhouse gases are accounted and reported in the waste sector in South Africa. Developing countries (including South Africa) do not have binding emission reduction targets, but many of them publish different greenhouse gas emissions data which have been accounted and reported in different ways. Results show that for South Africa, inventories at national and municipal level are the most important tools in the process of accounting and reporting greenhouse gases from waste. For the development of these inventories international initiatives were important catalysts at national and municipal levels, and assisted in developing local expertise, resulting in increased output quality. However, discrepancies in the methodology used to account greenhouse gases from waste between inventories still remain a concern. This is a challenging issue for developing countries, especially African ones, since higher accuracy methods are more data intensive. Analysis of the South African inventories shows that results from the recent inventories can not be compared with older ones due to the use of different accounting methodologies. More recently the use of Clean Development Mechanism (CDM) procedures in Africa, geared towards direct measurements of greenhouse gases from landfill sites, has increased and resulted in an improvement of the quality of greenhouse gas inventories at municipal level. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. Hydrophilic excipients modulate the time lag of time-controlled disintegrating press-coated tablets.

    PubMed

    Lin, Shan-Yang; Li, Mei-Jane; Lin, Kung-Hsu

    2004-08-16

    An oral press-coated tablet was developed by means of direct compression to achieve the time-controlled disintegrating or rupturing function with a distinct predetermined lag time. This press-coated tablet containing sodium diclofenac in the inner core was formulated with an outer shell by different weight ratios of hydrophobic polymer of micronized ethylcellulose (EC) powder and hydrophilic excipients such as spray-dried lactose (SDL) or hydroxypropyl methylcellulose (HPMC). The effect of the formulation of an outer shell comprising both hydrophobic polymer and hydrophilic excipients on the time lag of drug release was investigated. The release profile of the press-coated tablet exhibited a time period without drug release (time lag) followed by a rapid and complete release phase, in which the outer shell ruptured or broke into 2 halves. The lag phase was markedly dependent on the weight ratios of EC/SDL or EC/HPMC in the outer shell. Different time lags of the press-coated tablets from 1.0 to 16.3 hours could be modulated by changing the type and amount of the excipients. A semilogarithmic plot of the time lag of the tablet against the weight ratios of EC/SDL or EC/HPMC in the outer shell demonstrated a good linear relationship, with r = 0.976 and r = 0.982, respectively. The predetermined time lag prior to the drug release from a press-coated tablet prepared by using a micronized EC as a retarding coating shell can be adequately scheduled with the addition of hydrophilic excipients according to the time or site requirements.

  14. Assessing protein conformational sampling methods based on bivariate lag-distributions of backbone angles

    PubMed Central

    Maadooliat, Mehdi; Huang, Jianhua Z.

    2013-01-01

    Despite considerable progress in the past decades, protein structure prediction remains one of the major unsolved problems in computational biology. Angular-sampling-based methods have been extensively studied recently due to their ability to capture the continuous conformational space of protein structures. The literature has focused on using a variety of parametric models of the sequential dependencies between angle pairs along the protein chains. In this article, we present a thorough review of angular-sampling-based methods by assessing three main questions: What is the best distribution type to model the protein angles? What is a reasonable number of components in a mixture model that should be considered to accurately parameterize the joint distribution of the angles? and What is the order of the local sequence–structure dependency that should be considered by a prediction method? We assess the model fits for different methods using bivariate lag-distributions of the dihedral/planar angles. Moreover, the main information across the lags can be extracted using a technique called Lag singular value decomposition (LagSVD), which considers the joint distribution of the dihedral/planar angles over different lags using a nonparametric approach and monitors the behavior of the lag-distribution of the angles using singular value decomposition. As a result, we developed graphical tools and numerical measurements to compare and evaluate the performance of different model fits. Furthermore, we developed a web-tool (http://www.stat.tamu.edu/∼madoliat/LagSVD) that can be used to produce informative animations. PMID:22926831

  15. 76 FR 36400 - Third-Party Provision of Ancillary Services; Accounting and Financial Reporting for New Electric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ...-000 and AD10-13-000] Third-Party Provision of Ancillary Services; Accounting and Financial Reporting... current accounting and reporting requirements as applied to electric storage. As such, the Commission... the technologies used for such provision; and the adequacy of current accounting and reporting...

  16. Measuring attention using flash-lag effect.

    PubMed

    Shioiri, Satoshi; Yamamoto, Ken; Oshida, Hiroki; Matsubara, Kazuya; Yaguchi, Hirohisa

    2010-08-13

    We investigated the effect of attention on the flash-lag effect (FLE) in order to determine whether the FLE can be used to estimate the effect of visual attention. The FLE is the effect that a flash aligned with a moving object is perceived to lag the moving object, and several studies have shown that attention reduces its magnitude. We measured the FLE as a function of the number or speed of moving objects. The results showed that the effect of cueing, which we attributed the effect of attention, on the FLE increased monotonically with the number or the speed of the objects. This suggests that the amount of attention can be estimated by measuring the FLE, assuming that more amount of attention is required for a larger number or faster speed of objects to attend. On the basis of this presumption, we attempted to measure the spatial spread of visual attention by FLE measurements. The estimated spatial spreads were similar to those estimated by other experimental methods.

  17. Academic Self-Concept and Achievement in Polish Primary Schools: Cross-Lagged Modelling and Gender-Specific Effects

    ERIC Educational Resources Information Center

    Grygiel, Pawel; Modzelewski, Michal; Pisarek, Jolanta

    2017-01-01

    This study reports relationships between general academic self-concept and achievement in grade 3 and grade 5. Gender-specific effects were investigated using a longitudinal, two-cycle, 3-year autoregressive cross-lagged panel design in a large, representative sample of Polish primary school pupils (N = 4,226). Analysis revealed (a) reciprocal…

  18. Velocity lag of solid particles in oscillating gases and in gases passing through normal shock waves

    NASA Technical Reports Server (NTRS)

    Maxwell, B. R.; Seasholtz, R. G.

    1974-01-01

    The velocity lag of micrometer size spherical particles is theoretically determined for gas particle mixtures passing through a stationary normal shock wave and also for particles embedded in an oscillating gas flow. The particle sizes and densities chosen are those considered important for laser Doppler velocimeter applications. The governing equations for each flow system are formulated. The deviation from Stokes flow caused by inertial, compressibility, and rarefaction effects is accounted for in both flow systems by use of an empirical drag coefficient. Graphical results are presented which characterize particle tracking as a function of system parameters.

  19. [Relating costs to activities in hospitals. Use of internal cost accounting].

    PubMed

    Stavem, K

    1995-01-10

    During the last few years hospital cost accounting has become widespread in many countries, in parallel with increasing cost pressure, greater competition and new financing schemes. Cost accounting has been used in the manufacturing industry for many years. Costs can be related to activities and production, e.g. by the costing of procedures, episodes of care and other internally defined cost objectives. Norwegian hospitals have lagged behind in the adoption of cost accounting. They ought to act quickly if they want to be prepared for possible changes in health care financing. The benefits can be considerable to a hospital operating in a rapidly changing health care environment.

  20. 78 FR 48632 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... the confidentiality of borrower information. The system of internal controls, at a minimum, must... and maintain an effective system of internal controls over the data included in the report of accounts... system of internal controls, at a minimum, must comply with the requirements of applicable Farm Credit...

  1. 78 FR 77557 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ..., including controls for maintaining the confidentiality of borrower information. The system of internal... develop and implement an effective system of internal controls over the central data repository to ensure..., and maintain an effective system of internal controls over the data included in the report of accounts...

  2. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION... SITUATIONS Homeliving Programs Waivers and Accountability § 36.120 What type of reporting is required to ensure accountability? The homeliving program must provide to the appropriate local school board or...

  3. Eddy-covariance data with low signal-to-noise ratio: time-lag determination, uncertainties and limit of detection

    NASA Astrophysics Data System (ADS)

    Langford, B.; Acton, W.; Ammann, C.; Valach, A.; Nemitz, E.

    2015-10-01

    All eddy-covariance flux measurements are associated with random uncertainties which are a combination of sampling error due to natural variability in turbulence and sensor noise. The former is the principal error for systems where the signal-to-noise ratio of the analyser is high, as is usually the case when measuring fluxes of heat, CO2 or H2O. Where signal is limited, which is often the case for measurements of other trace gases and aerosols, instrument uncertainties dominate. Here, we are applying a consistent approach based on auto- and cross-covariance functions to quantify the total random flux error and the random error due to instrument noise separately. As with previous approaches, the random error quantification assumes that the time lag between wind and concentration measurement is known. However, if combined with commonly used automated methods that identify the individual time lag by looking for the maximum in the cross-covariance function of the two entities, analyser noise additionally leads to a systematic bias in the fluxes. Combining data sets from several analysers and using simulations, we show that the method of time-lag determination becomes increasingly important as the magnitude of the instrument error approaches that of the sampling error. The flux bias can be particularly significant for disjunct data, whereas using a prescribed time lag eliminates these effects (provided the time lag does not fluctuate unduly over time). We also demonstrate that when sampling at higher elevations, where low frequency turbulence dominates and covariance peaks are broader, both the probability and magnitude of bias are magnified. We show that the statistical significance of noisy flux data can be increased (limit of detection can be decreased) by appropriate averaging of individual fluxes, but only if systematic biases are avoided by using a prescribed time lag. Finally, we make recommendations for the analysis and reporting of data with low signal

  4. Eddy-covariance data with low signal-to-noise ratio: time-lag determination, uncertainties and limit of detection

    NASA Astrophysics Data System (ADS)

    Langford, B.; Acton, W.; Ammann, C.; Valach, A.; Nemitz, E.

    2015-03-01

    All eddy-covariance flux measurements are associated with random uncertainties which are a combination of sampling error due to natural variability in turbulence and sensor noise. The former is the principal error for systems where the signal-to-noise ratio of the analyser is high, as is usually the case when measuring fluxes of heat, CO2 or H2O. Where signal is limited, which is often the case for measurements of other trace gases and aerosols, instrument uncertainties dominate. We are here applying a consistent approach based on auto- and cross-covariance functions to quantifying the total random flux error and the random error due to instrument noise separately. As with previous approaches, the random error quantification assumes that the time-lag between wind and concentration measurement is known. However, if combined with commonly used automated methods that identify the individual time-lag by looking for the maximum in the cross-covariance function of the two entities, analyser noise additionally leads to a systematic bias in the fluxes. Combining datasets from several analysers and using simulations we show that the method of time-lag determination becomes increasingly important as the magnitude of the instrument error approaches that of the sampling error. The flux bias can be particularly significant for disjunct data, whereas using a prescribed time-lag eliminates these effects (provided the time-lag does not fluctuate unduly over time). We also demonstrate that when sampling at higher elevations, where low frequency turbulence dominates and covariance peaks are broader, both the probability and magnitude of bias are magnified. We show that the statistical significance of noisy flux data can be increased (limit of detection can be decreased) by appropriate averaging of individual fluxes, but only if systematic biases are avoided by using a prescribed time-lag. Finally, we make recommendations for the analysis and reporting of data with low signal

  5. National Aeronautics and Space Administration 1999 Accountability Report

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This Accountability Report consolidates reports required by various statutes and summarizes NASA's program accomplishments and its stewardship over budget and financial resources. It is a culmination of NASA's management process, which begins with mission definition and program planning, continues with the formulation and justification of budgets for the President and Congress, and ends with the resulting scientific and engineering program accomplishments. The report covers activities from October 1, 1998, through September 30, 1999, with a discussion of some subsequent events. Program accomplishments included the deployment and operation of the Chandra X-ray Observatory, the delivery of supplies and equipment needed to live and operate on the International Space Station, and the development of the first global 3-D map of Mars. Achievements are highlighted in the Statement of the Administrator and summarized in the performance section of this report.

  6. The Lag-Luminosity Relation in the GRB Source Frame: An Investigation with Swift BAT Bursts

    NASA Technical Reports Server (NTRS)

    Ukwatta, T. N.; Dhuga, K. S.; Stamatikos, M.; Dermer, C. D.; Sakamoto, T.; Sonbas, E.; Parke, W. C.; Maximon, L. C.; Linnemann, J. T.; Bhat, P. N.; hide

    2011-01-01

    Spectral lag. which is defined as the difference in time of arrival of high- and low-energy photons. is a common feature in gamma-ray bursts (GRBs). Previous investigations have shown a correlation between this lag and the isotropic peak luminosity for long duration bursts. However. most of the previous investigations used lags extracted in the observer frame only. In this work (based on a sample of 43 Swift long GRBs with known redshifts). we present an analysis of the lag-luminosity relation in the GRB source frame. Our analysis indicates a higher degree of correlation -0.82 +/- 0.05 (chance probability of approx. 5.5 x 10(exp -5) between the spectral lag and the isotropic peak luminosity, L(sub iso). with a best-fitting power-law index of -1.2 +/- 0.2. In addition, there is an anticorrelation between the source-frame spectral lag and the source-frame peak energy of the burst spectrum.

  7. A generalized expression for lag-time in the gas-phase permeation of hollow tubes

    NASA Technical Reports Server (NTRS)

    Shah, K. K.; Nelson, H. G.; Johnson, D. L.; Hamaker, F. M.

    1975-01-01

    A generalized expression for the nonsteady-state parameter, lag-time, has been obtained from Fick's second law for gas-phase transport through hollow, cylindrical membranes. This generalized expression is simplified for three limiting cases of practical interest: (1) diffusion controlled transport, (2) phase boundary reaction control at the inlet surface, and (3) phase boundary reaction control at the outlet surface. In all three cases the lag-time expressions were found to be inversely proportional only to the diffusion coefficient and functionally dependent on the membrane radii. Finally, the lag-time expressions were applied to experimentally obtained lag-time data for alpha-phase titanium and alpha-phase iron.

  8. School Accountability Reports: A Five-Year Review of Progress (2000-2005)

    ERIC Educational Resources Information Center

    Colorado Department of Education, 2005

    2005-01-01

    The report was issued as a statutory requirement of the Colorado State Board of Education. The report was directed to include, but not be limited to: (1) Whether student scores have improved since the accountability reports were issued in 2001; (2) Data on safety incidents involving students; (3) Whether the format of the School Accountability…

  9. Electronic trigger for capacitive touchscreen and extension of ISO 15781 standard time lag measurements to smartphones

    NASA Astrophysics Data System (ADS)

    Bucher, François-Xavier; Cao, Frédéric; Viard, Clément; Guichard, Frédéric

    2014-03-01

    We present in this paper a novel capacitive device that stimulates the touchscreen interface of a smartphone (or of any imaging device equipped with a capacitive touchscreen) and synchronizes triggering with the DxO LED Universal Timer to measure shooting time lag and shutter lag according to ISO 15781:2013. The device and protocol extend the time lag measurement beyond the standard by including negative shutter lag, a phenomenon that is more and more commonly found in smartphones. The device is computer-controlled, and this feature, combined with measurement algorithms, makes it possible to automatize a large series of captures so as to provide more refined statistical analyses when, for example, the shutter lag of "zero shutter lag" devices is limited by the frame time as our measurements confirm.

  10. Independent Auditors Report on the FY 2015 DoD Detailed Accounting Report for the Funds Obligated for National Drug Control Program Activities

    DTIC Science & Technology

    2016-01-29

    No. DODIG-2016-041 J A N U A R Y 2 9 , 2 0 1 6 Independent Auditor’s Report on the FY 2015 DoD Detailed Accounting Report for the Funds...Defense that supports the warfighter; promotes accountability , integrity, and efficiency; advises the Secretary of Defense and Congress; and informs...THE ARMY SUBJECT: Independent Auditor’s Report on the FY 2015 DoD Detailed Accounting Report for the Funds Obligated for National Drug Control

  11. A simple method to assess unsaturated zone time lag in the travel time from ground surface to receptor.

    PubMed

    Sousa, Marcelo R; Jones, Jon P; Frind, Emil O; Rudolph, David L

    2013-01-01

    In contaminant travel from ground surface to groundwater receptors, the time taken in travelling through the unsaturated zone is known as the unsaturated zone time lag. Depending on the situation, this time lag may or may not be significant within the context of the overall problem. A method is presented for assessing the importance of the unsaturated zone in the travel time from source to receptor in terms of estimates of both the absolute and the relative advective times. A choice of different techniques for both unsaturated and saturated travel time estimation is provided. This method may be useful for practitioners to decide whether to incorporate unsaturated processes in conceptual and numerical models and can also be used to roughly estimate the total travel time between points near ground surface and a groundwater receptor. This method was applied to a field site located in a glacial aquifer system in Ontario, Canada. Advective travel times were estimated using techniques with different levels of sophistication. The application of the proposed method indicates that the time lag in the unsaturated zone is significant at this field site and should be taken into account. For this case, sophisticated and simplified techniques lead to similar assessments when the same knowledge of the hydraulic conductivity field is assumed. When there is significant uncertainty regarding the hydraulic conductivity, simplified calculations did not lead to a conclusive decision. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. The Effect of International Financial Reporting Standards Convergence on U. S. Accounting Curriculum

    ERIC Educational Resources Information Center

    Bates, Homer L.; Waldrup, Bobby E.; Shea, Vincent

    2011-01-01

    Major changes are coming to U.S. financial accounting and accounting education as U. S. generally accepted accounting principles (GAAP) and international financial reporting standards (IFRS) converge within the next few years. In 2008, the U.S. Securities and Exchange Commission (SEC) published a proposed "road map" for the potential…

  13. Toward a Measure of Accountability in Nursing: A Three-Stage Validation Study.

    PubMed

    Drach-Zahavy, Anat; Leonenko, Marina; Srulovici, Einav

    2018-06-04

    To develop and psychometrically evaluate a three-dimensional questionnaire suitable for evaluating personal and organizational accountability in nurses. Accountability is defined as a three-dimensional value, directing professionals to take responsibility for their decisions and actions, to be willing to explain them (transparency) and to be judged according to society's accepted values (answerability). Despite the relatively clear definition, measurement of accountability lags well behind. Existing self-report questionnaires do not fully capture the complexity of the concept; nor do they capture the different sources of accountability (e.g., personal accountability, organizational accountability). A three-stage measure development. Data were collected during 2015-2016. In Phase 1, an initial database of items (N = 74) was developed, based on literature review and qualitative study, establishing face and content validity. In Phase 2, the face, content, construct and criterion-related validity of the initial questionnaires (19 items for personal and organizational accountability questionnaire) was established with a sample of 229 nurses. In Phase 3, the final questionnaires (19 items each) were validated with a new sample of 329 nurses and established construct validity. The final version of the instruments comprised 19 items, suitable for assessing personal and organizational accountability. The questionnaire referred to the dimensions of responsibility, transparency and answerability. The findings established the instrument's content, construct and criterion-related validity, as well as good internal reliability. The questionnaire portrays accountability in nursing, by capturing nurses' subjective perceptions of accountability dimensions (responsibility, transparency, answerability), as demonstrated by personal and organizational values. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  14. Anticipated and zero-lag synchronization in motifs of delay-coupled systems

    NASA Astrophysics Data System (ADS)

    Mirasso, Claudio R.; Carelli, Pedro V.; Pereira, Tiago; Matias, Fernanda S.; Copelli, Mauro

    2017-11-01

    Anticipated and zero-lag synchronization have been observed in different scientific fields. In the brain, they might play a fundamental role in information processing, temporal coding and spatial attention. Recent numerical work on anticipated and zero-lag synchronization studied the role of delays. However, an analytical understanding of the conditions for these phenomena remains elusive. In this paper, we study both phenomena in systems with small delays. By performing a phase reduction and studying phase locked solutions, we uncover the functional relation between the delay, excitation and inhibition for the onset of anticipated synchronization in a sender-receiver-interneuron motif. In the case of zero-lag synchronization in a chain motif, we determine the stability conditions. These analytical solutions provide an excellent prediction of the phase-locked regimes of Hodgkin-Huxley models and Roessler oscillators.

  15. Federally Sponsored Research at Educational Institutions: A Need for Improved Accountability. Report by the U.S. General Accounting Office.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    This report discusses federally sponsored research at educational institutions and suggests ways to improve accountability for these funds. The following suggestions are made for minimizing problems presented in this report: (1) development of more definitive cost principles for both the institutions and the Federal auditors to follow; (2) more…

  16. Daily stress and emotional well-being among Asian American adolescents: same-day, lagged, and chronic associations.

    PubMed

    Kiang, Lisa; Buchanan, Christy M

    2014-02-01

    Daily-diary data from 180 Asian American 9th-10th graders (58% female, 75% second generation; M age = 14.97 years) were used to investigate how family, school, and peer stress are each associated with same-day and next-day (lagged) well-being, and vice versa. Hierarchical linear modeling provided support for reciprocal links when considering same-day reports. More daily stress was associated with lower same-day happiness and higher distress and anxiety. At the same time, well-being was associated with same-day stress, although the specific patterns were not as consistent and varied somewhat by stress domain. With a 1-day lag between daily experiences, stress was not associated with next-day well-being, but daily distress was associated with more next-day family stress. Females and first-generation adolescents were particularly vulnerable to daily stress and well-being processes. Sustained effects were also found in that chronic experiences of school stress over the 14-day period were associated with higher reports of depression and anxiety.

  17. [Effects of orthokeratology lenses on the magnitude of accommodative lag and accommodativeconvergence/accommodation].

    PubMed

    Ren, Qiujin; Yue, Hui; Zhou, Qing

    2016-02-01

    To evaluate the change in accommodative lag and accommodation convergence/accommodation (AC/A) after patients with myopia wear orthokeratology lenses. 
 A total of 48 myopic subjects (a test group), who wore orthokeratology lenses regularly, and 48 myopic subjects (a control group), who wore spectacles regularly, were enrolled for this study from January 2011 to January 2013 in Optometric Center, the Forth Hospital of Changsha. Accommodative lag was measured by fused cross cylinder method, where the patients should gaze at the front optotypes 40 cm away. Gradient of the AC/A ratio was measured by Von Grafe method to check closer distance heterophoria. Accommodative lag and AC/A ratio were analyzed by statistics.
 After 1-year follow-up, accommodative lag and AC/A rate in patients with low or moderate myopia in the test group was decreased in 1, 3, 6 months or 1 year compared with that in the control group (P<0.05). 
 Compared with spectacles, orthokeratology lenses are able to decrease accommodative lag and high AC/A rate in patients with low or moderate myopia. The relationship between accommodation and convergence is improved by orthokeratology lenses. Orthokeratology is an effective way to control myopia.

  18. The Reverberation Lag in the Low-mass X-ray Binary H1743-322

    NASA Astrophysics Data System (ADS)

    De Marco, Barbara; Ponti, Gabriele

    2016-07-01

    The evolution of the inner accretion flow of a black hole X-ray binary during an outburst is still a matter of active research. X-ray reverberation lags are powerful tools for constraining disk-corona geometry. We present a study of X-ray lags in the black hole transient H1743-322. We compared the results obtained from analysis of all the publicly available XMM-Newton observations. These observations were carried out during two different outbursts that occurred in 2008 and 2014. During all the observations the source was caught in the hard state and at similar luminosities ({L}3-10{keV}/{L}{Edd}˜ 0.004). We detected a soft X-ray lag of ˜60 ms, most likely due to thermal reverberation. We did not detect any significant change of the lag amplitude among the different observations, indicating a similar disk-corona geometry at the same luminosity in the hard state. On the other hand, we observe significant differences between the reverberation lag detected in H1743-322 and in GX 339-4 (at similar luminosities in the hard state), which might indicate variations of the geometry from source to source.

  19. Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation

    PubMed Central

    Sega, Emanuela I.; Leveson-Gower, Dennis B.; Florek, Mareike; Schneidawind, Dominik; Luong, Richard H.; Negrin, Robert S.

    2014-01-01

    Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cell responses after bone marrow transplantation. We demonstrate that Lag-3 deficient Tcon (Lag-3−/− Tcon) induce significantly more severe GVHD than wild type (WT) Tcon and that the absence of Lag-3 on CD4 but not CD8 T cells is responsible for exacerbating GVHD. Lag-3−/− Tcon exhibited increased activation and proliferation as indicated by CFSE and bioluminescence imaging analyses and higher levels of activation markers such as CD69, CD107a, granzyme B, and Ki-67 as well as production of IL-10 and IFN-g early after transplantation. Lag-3−/− Tcon were less responsive to suppression by WT Treg as compared to WT Tcon. The absence of Lag-3, however, did not impair Treg function as both Lag-3−/− and WT Treg equally suppress the proliferation of Tcon in vitro and in vivo and protect against GVHD. Further, we demonstrate that allogeneic Treg acquire recipient MHC class II molecules through a process termed trogocytosis. As MHC class II is a ligand for Lag-3, we propose a novel suppression mechanism employed by Treg involving the acquisition of host MHC-II followed by the engagement of Lag-3 on T cells. These studies demonstrate for the first time the biologic function of Lag-3 expression on conventional and regulatory T cells in GVHD and identify Lag-3 as an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation. PMID:24475140

  20. EVOLUTION OF THE CROSS-CORRELATION AND TIME LAG OF 4U 1735-44 ALONG THE BRANCHES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lei Yajuan; Zhang Haotong; Zhang Chengmin

    We analyze the cross-correlation function between the soft and hard X-rays of atoll source 4U 1735-44 with RXTE data, and find anti-correlated soft and hard time lags of about a hecto-second. In the island state, the observations do not show any obvious correlations, and most observations of the banana branch show a positive correlation. However, anti-correlations are detected in the upper banana branch. These results are different from those of Z-sources (Cyg X-2, GX 5-1), where anti-correlations are detected in the horizontal branch and upper normal branch. In this case, the lag timescales of both this atoll and Z-sources aremore » found to be similar, at a magnitude of several tens to hundreds of seconds. As a comparison, it is noted that anti-correlated lags lasting thousands of seconds have been reported from several black hole candidates in their intermediate states. In addition, for an observation containing four segments that show positive or anti-correlation, we analyze the spectral evolution with the hybrid model. In the observation, the anti-correlation is detected at the highest flux. The fitting results show that the Comptonized component is not the lowest at the highest flux, which suggests that the anti-correlation corresponds to the transition between the soft and hard states. Finally, we compare the corresponding results of atoll source 4U 1735-44 with those observed in Z-sources and black hole candidates, and the possible origins of the anti-correlated time lags are discussed.« less

  1. An investigation of the lag between the start of research and the development of new technology

    NASA Technical Reports Server (NTRS)

    Glass, S. E.

    1982-01-01

    The lag which occurs between the start of NASA-sponsored research and the development of new technology is addressed. A possible common gestation period is examined. The lags vary from one to zero years. The observed lag as it relates to patent applications is shorter than the lag as it relates to invention disclosures. The sequential hypothesis testing showed that invention disclosures correlated better to the measures of research effort used then did patent applications.

  2. Leading and lagging indicators of occupational health and safety: The moderating role of safety leadership.

    PubMed

    Sheehan, Cathy; Donohue, Ross; Shea, Tracey; Cooper, Brian; Cieri, Helen De

    2016-07-01

    In response to the call for empirical evidence of a connection between leading and lagging indicators of occupational health and safety (OHS), the first aim of the current research is to consider the association between leading and lagging indicators of OHS. Our second aim is to investigate the moderating effect of safety leadership on the association between leading and lagging indicators. Data were collected from 3578 employees nested within 66 workplaces. Multi-level modelling was used to test the two hypotheses. The results confirm an association between leading and lagging indicators of OHS as well as the moderating impact of middle management safety leadership on the direct association. The association between leading and lagging indicators provides OHS practitioners with useful information to substantiate efforts within organisations to move away from a traditional focus on lagging indicators towards a preventative focus on leading indicators. The research also highlights the important role played by middle managers and the value of OHS leadership development and investment at the middle management level. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. 10 CFR 60.78 - Material control and accounting records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Material control and accounting records and reports. 60.78 Section 60.78 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Records, Reports, Tests, and Inspections § 60.78 Material control and...

  4. Analysis and IbM simulation of the stages in bacterial lag phase: basis for an updated definition.

    PubMed

    Prats, Clara; Giró, Antoni; Ferrer, Jordi; López, Daniel; Vives-Rego, Josep

    2008-05-07

    The lag phase is the initial phase of a culture that precedes exponential growth and occurs when the conditions of the culture medium differ from the pre-inoculation conditions. It is usually defined by means of cell density because the number of individuals remains approximately constant or slowly increases, and it is quantified with the lag parameter lambda. The lag phase has been studied through mathematical modelling and by means of specific experiments. In recent years, Individual-based Modelling (IbM) has provided helpful insights into lag phase studies. In this paper, the definition of lag phase is thoroughly examined. Evolution of the total biomass and the total number of bacteria during lag phase is tackled separately. The lag phase lasts until the culture reaches a maximum growth rate both in biomass and cell density. Once in the exponential phase, both rates are constant over time and equal to each other. Both evolutions are split into an initial phase and a transition phase, according to their growth rates. A population-level mathematical model is presented to describe the transitional phase in cell density. INDividual DIScrete SIMulation (INDISIM) is used to check the outcomes of this analysis. Simulations allow the separate study of the evolution of cell density and total biomass in a batch culture, they provide a depiction of different observed cases in lag evolution at the individual-cell level, and are used to test the population-level model. The results show that the geometrical lag parameter lambda is not appropriate as a universal definition for the lag phase. Moreover, the lag phase cannot be characterized by a single parameter. For the studied cases, the lag phases of both the total biomass and the population are required to fully characterize the evolution of bacterial cultures. The results presented prove once more that the lag phase is a complex process that requires a more complete definition. This will be possible only after the phenomena

  5. 17 CFR 17.01 - Identification of special accounts, volume threshold accounts, and omnibus accounts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Identification of special accounts, volume threshold accounts, and omnibus accounts. 17.01 Section 17.01 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REPORTS BY REPORTING MARKETS, FUTURES COMMISSION MERCHANTS, CLEARING MEMBERS, AND FOREIGN BROKERS §...

  6. Is Exposure to Income Inequality a Public Health Concern? Lagged Effects of Income Inequality on Individual and Population Health

    PubMed Central

    Mellor, Jennifer M; Milyo, Jeffrey

    2003-01-01

    Objective To examine the health consequences of exposure to income inequality. Data Sources Secondary analysis employing data from several publicly available sources. Measures of individual health status and other individual characteristics are obtained from the March Current Population Survey (CPS). State-level income inequality is measured by the Gini coefficient based on family income, as reported by the U.S. Census Bureau and Al-Samarrie and Miller (1967). State-level mortality rates are from the Vital Statistics of the United States; other state-level characteristics are from U.S. census data as reported in the Statistical Abstract of the United States. Study Design We examine the effects of state-level income inequality lagged from 5 to 29 years on individual health by estimating probit models of poor/fair health status for samples of adults aged 25–74 in the 1995 through 1999 March CPS. We control for several individual characteristics, including educational attainment and household income, as well as regional fixed effects. We use multivariate regression to estimate the effects of income inequality lagged 10 and 20 years on state-level mortality rates for 1990, 1980, 1970, and 1960. Principal Findings Lagged income inequality is not significantly associated with individual health status after controlling for regional fixed effects. Lagged income inequality is not associated with all cause mortality, but associated with reduced mortality from cardiovascular disease and malignant neoplasms, after controlling for state fixed-effects. Conclusions In contrast to previous studies that fail to control for regional variations in health outcomes, we find little support for the contention that exposure to income inequality is detrimental to either individual or population health. PMID:12650385

  7. A forward bias method for lag correction of an a-Si flat panel detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Starman, Jared; Tognina, Carlo; Partain, Larry

    2012-01-15

    Purpose: Digital a-Si flat panel (FP) x-ray detectors can exhibit detector lag, or residual signal, of several percent that can cause ghosting in projection images or severe shading artifacts, known as the radar artifact, in cone-beam computed tomography (CBCT) reconstructions. A major contributor to detector lag is believed to be defect states, or traps, in the a-Si layer of the FP. Software methods to characterize and correct for the detector lag exist, but they may make assumptions such as system linearity and time invariance, which may not be true. The purpose of this work is to investigate a new hardwaremore » based method to reduce lag in an a-Si FP and to evaluate its effectiveness at removing shading artifacts in CBCT reconstructions. The feasibility of a novel, partially hardware based solution is also examined. Methods: The proposed hardware solution for lag reduction requires only a minor change to the FP. For pulsed irradiation, the proposed method inserts a new operation step between the readout and data collection stages. During this new stage the photodiode is operated in a forward bias mode, which fills the defect states with charge. A Varian 4030CB panel was modified to allow for operation in the forward bias mode. The contrast of residual lag ghosts was measured for lag frames 2 and 100 after irradiation ceased for standard and forward bias modes. Detector step response, lag, SNR, modulation transfer function (MTF), and detective quantum efficiency (DQE) measurements were made with standard and forward bias firmware. CBCT data of pelvic and head phantoms were also collected. Results: Overall, the 2nd and 100th detector lag frame residual signals were reduced 70%-88% using the new method. SNR, MTF, and DQE measurements show a small decrease in collected signal and a small increase in noise. The forward bias hardware successfully reduced the radar artifact in the CBCT reconstruction of the pelvic and head phantoms by 48%-81%. Conclusions: Overall

  8. Early biometric lag in the prediction of small for gestational age neonates and preeclampsia.

    PubMed

    Schwartz, Nadav; Pessel, Cara; Coletta, Jaclyn; Krieger, Abba M; Timor-Tritsch, Ilan E

    2011-01-01

    An early fetal growth lag may be a marker of future complications. We sought to determine the utility of early biometric variables in predicting adverse pregnancy outcomes. In this retrospective cohort study, the crown-rump length at 11 to 14 weeks and the head circumference, biparietal diameter, abdominal circumference, femur length, humerus length, transverse cerebellar diameter, and estimated fetal weight at 18 to 24 weeks were converted to an estimated gestational age using published regression formulas. Sonographic fetal growth (difference between each biometric gestational age and the crown-rump length gestational age) minus expected fetal growth (number of days elapsed between the two scans) yielded the biometric growth lag. These lags were tested as predictors of small for gestational age (SGA) neonates (≤10th percentile) and preeclampsia. A total of 245 patients were included. Thirty-two (13.1%) delivered an SGA neonate, and 43 (17.6%) had the composite outcome. The head circumference, biparietal diameter, abdominal circumference, and estimated fetal weight lags were identified as significant predictors of SGA neonates after adjusted analyses (P < .05). The addition of either the estimated fetal weight or abdominal circumference lag to maternal characteristics alone significantly improved the performance of the predictive model, achieving areas under the curve of 0.72 and 0.74, respectively. No significant association was found between the biometric lag variables and the development of preeclampsia. Routinely available biometric data can be used to improve the prediction of adverse outcomes such as SGA. These biometric lags should be considered in efforts to develop screening algorithms for adverse outcomes.

  9. Effects of timber harvesting on the lag time of Caspar Creek watershed

    Treesearch

    Karen Hardison Sendek

    1985-01-01

    Abstract - Hydrograph lag time was analyzed to determine changes after road construction and after selective, tractor-yarded logging in a Caspar Creek watershed, Mendocino County, California. The paired watershed technique was used. Hydrograph lag time for each storm was the time separation between the midpoint of precipitation and the time coordinate of the runoff...

  10. The Impact of International Financial Reporting Standards on Accounting Curriculum in the United States

    ERIC Educational Resources Information Center

    Yallapragada, RamMohan R.; Toma, Alfred G.; Roe, C. William

    2011-01-01

    According to the time line presently specified by the Securities and Exchange Commission (SEC), business firms in the United States (US) should switch from the existing US accounting reporting guidelines of the Generally Accepted Accounting Principles (GAAP) to International Financial Reporting Standards (IFRS) by the year 2014. The US business…

  11. Exploring lag times between monthly atmospheric deposition and stream chemistry in Appalachian forests using cross-correlation

    NASA Astrophysics Data System (ADS)

    DeWalle, David R.; Boyer, Elizabeth W.; Buda, Anthony R.

    2016-12-01

    Forecasts of ecosystem changes due to variations in atmospheric emissions policies require a fundamental understanding of lag times between changes in chemical inputs and watershed response. Impacts of changes in atmospheric deposition in the United States have been documented using national and regional long-term environmental monitoring programs beginning several decades ago. Consequently, time series of weekly NADP atmospheric wet deposition and monthly EPA-Long Term Monitoring stream chemistry now exist for much of the Northeast which may provide insights into lag times. In this study of Appalachian forest basins, we estimated lag times for S, N and Cl by cross-correlating monthly data from four pairs of stream and deposition monitoring sites during the period from 1978 to 2012. A systems or impulse response function approach to cross-correlation was used to estimate lag times where the input deposition time series was pre-whitened using regression modeling and the stream response time series was filtered using the deposition regression model prior to cross-correlation. Cross-correlations for S were greatest at annual intervals over a relatively well-defined range of lags with the maximum correlations occurring at mean lags of 48 months. Chloride results were similar but more erratic with a mean lag of 57 months. Few high-correlation lags for N were indicated. Given the growing availability of atmospheric deposition and surface water chemistry monitoring data and our results for four Appalachian basins, further testing of cross-correlation as a method of estimating lag times on other basins appears justified.

  12. Minimization of diauxic growth lag-phase for high-efficiency biogas production.

    PubMed

    Kim, Min Jee; Kim, Sang Hun

    2017-02-01

    The objective of this study was to develop a minimization method of a diauxic growth lag-phase for the biogas production from agricultural by-products (ABPs). Specifically, the effects of proximate composition on the biogas production and degradation rates of the ABPs were investigated, and a new method based on proximate composition combinations was developed to minimize the diauxic growth lag-phase. Experiments were performed using biogas potential tests at a substrate loading of 2.5 g VS/L and feed to microorganism ratio (F/M) of 0.5 under the mesophilic condition. The ABPs were classified based on proximate composition (carbohydrate, protein, and fat etc.). The biogas production patterns, lag phase, and times taken for 90% biogas production (T90) were used for the evaluation of the biogas production with biochemical methane potential (BMP) test. The high- or medium-carbohydrate and low-fat ABPs (cheese whey, cabbage, and skim milk) showed a single step digestion process and low-carbohydrate and high-fat ABPs (bean curd and perilla seed) showed a two-step digestion process. The mixture of high-fat ABPs and high-carbohydrate ABPs reduced the lag-phase and increased the biogas yield more than that from single ABP by 35-46%. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. How to compare cross-lagged associations in a multilevel autoregressive model.

    PubMed

    Schuurman, Noémi K; Ferrer, Emilio; de Boer-Sonnenschein, Mieke; Hamaker, Ellen L

    2016-06-01

    By modeling variables over time it is possible to investigate the Granger-causal cross-lagged associations between variables. By comparing the standardized cross-lagged coefficients, the relative strength of these associations can be evaluated in order to determine important driving forces in the dynamic system. The aim of this study was twofold: first, to illustrate the added value of a multilevel multivariate autoregressive modeling approach for investigating these associations over more traditional techniques; and second, to discuss how the coefficients of the multilevel autoregressive model should be standardized for comparing the strength of the cross-lagged associations. The hierarchical structure of multilevel multivariate autoregressive models complicates standardization, because subject-based statistics or group-based statistics can be used to standardize the coefficients, and each method may result in different conclusions. We argue that in order to make a meaningful comparison of the strength of the cross-lagged associations, the coefficients should be standardized within persons. We further illustrate the bivariate multilevel autoregressive model and the standardization of the coefficients, and we show that disregarding individual differences in dynamics can prove misleading, by means of an empirical example on experienced competence and exhaustion in persons diagnosed with burnout. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  14. Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece.

    PubMed

    Nikolopoulos, G K; Katsoulidou, A; Kantzanou, M; Rokka, C; Tsiara, C; Sypsa, V; Paraskevis, D; Psichogiou, M; Friedman, S; Hatzakis, A

    2017-01-01

    This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected >6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85·7%. The PFR was 20·8% but fell to 5·9% in samples from treatment-naive individuals with long-standing infection (>1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3·3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log10 HIV RNA level was high (5·30, interquartile range 4·56-5·90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.

  15. Flash-lag effect: complicating motion extrapolation of the moving reference-stimulus paradoxically augments the effect.

    PubMed

    Bachmann, Talis; Murd, Carolina; Põder, Endel

    2012-09-01

    One fundamental property of the perceptual and cognitive systems is their capacity for prediction in the dynamic environment; the flash-lag effect has been considered as a particularly suggestive example of this capacity (Nijhawan in nature 370:256-257, 1994, Behav brain sci 31:179-239, 2008). Thus, because of involvement of the mechanisms of extrapolation and visual prediction, the moving object is perceived ahead of the simultaneously flashed static object objectively aligned with the moving one. In the present study we introduce a new method and report experimental results inconsistent with at least some versions of the prediction/extrapolation theory. We show that a stimulus moving in the opposite direction to the reference stimulus by approaching it before the flash does not diminish the flash-lag effect, but rather augments it. In addition, alternative theories (in)capable of explaining this paradoxical result are discussed.

  16. 37 CFR 201.29 - Access to, and confidentiality of, Statements of Account, Verification Auditor's Reports, and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... confidentiality of, Statements of Account, Verification Auditor's Reports, and other verification information... GENERAL PROVISIONS § 201.29 Access to, and confidentiality of, Statements of Account, Verification Auditor... Account, including the Primary Auditor's Reports, filed under 17 U.S.C. 1003(c) and access to a Verifying...

  17. Peripheral Design of Progressive Addition Lenses and the Lag of Accommodation in Myopes.

    PubMed

    Schilling, Tim; Ohlendorf, Arne; Varnas, Saulius R; Wahl, Siegfried

    2017-07-01

    Insufficient accommodative response is assumed to result in myopia progression. We have investigated if the accommodative lag in myopes is different between a single vision lens (SVL) and the progressive addition lens PAL 2, clinically trialled for its ability to reduce progression of myopia, and if there exist differences in accommodative lag between PAL 2 and other PALs with the same addition power (+1.50 D). The influence of spherical SVL and four different designs of PALs that differ in the near zone width (PAL 1) or that have different signs and magnitude of horizontal gradients of mean power adjacent to their near vision zones (PAL 3 and PAL 4) on the accommodative response was investigated for different near viewing distances (40, 33, and 25 cm) in 31 subjects, aged 18 to 25 years. The SVL correction resulted in insufficient accommodative response for the near object viewing distances tested. PAL 2 did significantly reduce accommodative lag for all near object distances tested. The PAL design with a more negative horizontal mean power gradient (PAL 4) provided a lower lag of accommodation when compared with PAL 2 at the shortest object distance of 25 cm (P = 0.03) and was able to reduce the lag of accommodation to a level below the depth of focus for the higher near working distances tested. Designs of PAL with more negative horizontal mean power gradients are the most effective in lowering the lag of accommodation in myopes. This could make them good test candidates for myopia control applications.

  18. Task Force on Education Funding Equity, Accountability, and Partnerships. Preliminary Report.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Legislative Services, Annapolis.

    In 1997, Maryland formed the Task Force on Education Funding Equity, Accountability, and Partnerships to ensure that students throughout Maryland have an equal opportunity for academic success. The Task Force's preliminary report features a comprehensive review of education funding and programs in grades K-12. The report presents membership and…

  19. Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity.

    PubMed

    Castelli, Chiara; Triebel, Frédéric; Rivoltini, Licia; Camisaschi, Chiara

    2014-11-01

    We have recently reported that lymphocyte activation gene-3 (LAG-3,CD223) mediates the alternative, IFNα-deficient activation of plasmacytoid dendritic cells (pDCs) at tumor sites. Our findings define a novel tumor-driven strategy that promotes immunosuppression by pDCs, and we have provided more detailed information regarding the immunomodulatory role of of LAG-3. The translational relevance of our results for the treatment of tumors and autoimmune diseases is discussed herein.

  20. The lag effects and vulnerabilities of temperature effects on cardiovascular disease mortality in a subtropical climate zone in China.

    PubMed

    Huang, Jixia; Wang, Jinfeng; Yu, Weiwei

    2014-04-11

    This research quantifies the lag effects and vulnerabilities of temperature effects on cardiovascular disease in Changsha--a subtropical climate zone of China. A Poisson regression model within a distributed lag nonlinear models framework was used to examine the lag effects of cold- and heat-related CVD mortality. The lag effect for heat-related CVD mortality was just 0-3 days. In contrast, we observed a statistically significant association with 10-25 lag days for cold-related CVD mortality. Low temperatures with 0-2 lag days increased the mortality risk for those ≥65 years and females. For all ages, the cumulative effects of cold-related CVD mortality was 6.6% (95% CI: 5.2%-8.2%) for 30 lag days while that of heat-related CVD mortality was 4.9% (95% CI: 2.0%-7.9%) for 3 lag days. We found that in Changsha city, the lag effect of hot temperatures is short while the lag effect of cold temperatures is long. Females and older people were more sensitive to extreme hot and cold temperatures than males and younger people.

  1. A Comparison of Several Methods of Measuring Ignition Lag in a Compression-ignition Engine

    NASA Technical Reports Server (NTRS)

    Spanogle, J A

    1934-01-01

    The ignition lag of a fuel oil in the combustion chamber of a high speed compression-ignition engine was measured by three different methods. The start of injection of the fuel as observed with a Stoborama was taken as the start of the period of ignition lag in all cases. The end of the period of ignition lag was determined by observation of the appearance of incandescence in the combustion chamber, by inspection of a pressure-time card for evidence of pressure rise, and by analysis of the indicator card for evidence of the combustion of a small but definite quantity of fuel. A comparison of the values for ignition lags obtained by these three methods indicates that the appearance of incandescence is later than other evidences of the start of combustion, that visual inspection of a pressure-time diagram gives consistent and usable values with a minimum requirement of time and/or apparatus, and that analysis of the indicator card is not worth while for ignition lag alone.

  2. Estimation of watershed lag times and times of concentration for the Kansas City Area : technical summary.

    DOT National Transportation Integrated Search

    2016-04-01

    The new lag-time equation for the Kansas City area performs better than the 2001 KU-KDOT equation for urban lag time, which was developed from a study of 14 gaged watersheds in Johnson County (McEnroe & Zhao, 2001). The main advantage of the new lag-...

  3. Neglecting Democracy in Education Policy: A-F School Report Card Accountability Systems

    ERIC Educational Resources Information Center

    Murray, Kevin; Howe, Kenneth R.

    2017-01-01

    Sixteen states have adopted school report card accountability systems that assign A-F letter grades to schools. Other states are now engaged in deliberation about whether they, too, should adopt such systems. This paper examines A-F accountability systems with respect to three kinds of validity. First, it examines whether or not these…

  4. Effect of Repetition Lag on Priming of Unfamiliar Visual Objects in Young and Older Adults

    PubMed Central

    Gordon, Leamarie T.; Soldan, Anja; Thomas, Ayanna K.; Stern, Yaakov

    2013-01-01

    Across three experiments, we examined the effect of repetition lag on priming of unfamiliar visual objects in healthy young and older adults. Multiple levels of lag were examined, ranging from short (one to four intervening stimuli) to long (50+ intervening stimuli). In each experiment, subjects viewed a series of new and repeated line drawings of objects and decided whether they depicted structurally possible or impossible figures. Experiment 1 and 2 found similar levels of priming in young and older adults at short and medium lags. At the longer repetition lags (∼20+ intervening stimuli), older adults showed less overall priming, as measured by reaction time facilitation, than young adults. This indicates that older adults can rapidly encode unfamiliar three-dimensional objects to support priming at shorter lags; however, they cannot maintain these representations over longer intervals. In addition to repetition lag, we also explored the relationship between priming and cognitive reserve, as measured by education and verbal intelligence. In the older adults, higher levels of cognitive reserve were associated with greater reaction time priming, suggesting that cognitive reserve may mediate the relationship between aging and priming. PMID:23276220

  5. Principles of Public School Accounting. State Educational Records and Reports Series: Handbook II-B.

    ERIC Educational Resources Information Center

    Adams, Bert K.; And Others

    This handbook discusses the following primary aspects of school accounting: Definitions and principles; opening the general ledger; recording the approved budget; a sample month of transactions; the balance sheet, monthly, and annual reports; subsidiary journals; payroll procedures; cafeteria fund accounting; debt service accounting; construction…

  6. Greater Effect of East versus West Travel on Jet Lag, Sleep, and Team Sport Performance.

    PubMed

    Fowler, Peter M; Knez, Wade; Crowcroft, Stephen; Mendham, Amy E; Miller, Joanna; Sargent, Charlie; Halson, Shona; Duffield, Rob

    2017-12-01

    This study aimed to determine the recovery timeline of sleep, subjective jet lag and fatigue, and team sport physical performance after east and west long-haul travel. Ten physically trained men underwent testing at 0900 h and 1700 h local time on four consecutive days 2 wk before outbound travel (BASE), and the first 4 d after 21 h of outbound (WEST) and return (EAST) air travel across eight time zones between Australia and Qatar. Data collection included performance (countermovement jump, 20-m sprint, and Yo-Yo intermittent recovery level 1 [YYIR1] test) and perceptual (jet lag, motivation, perceived exertion, and physical feeling) measures. In addition, sleep was measured via wrist activity monitors and self-report diaries throughout the aforementioned data collection periods. Compared with the corresponding day at BASE, the reduction in YYIR1 distance after EAST was significantly different from the increase in WEST on day 1 after travel (P < 0.001). On day 2, significantly slower 20-m sprint times were detected in EAST compared with WEST (P = 0.03), with large effect sizes (ES) also indicating a greater reduction in YYIR1 distance in EAST compared with WEST (d = 1.06). Mean sleep onset and offset were significantly later and mean time in bed and sleep duration were significantly reduced across the 4 d in EAST compared with BASE and WEST (P < 0.05). Lastly, mean jet lag, fatigue, and motivation ratings across the 4 d were significantly worse in EAST compared with BASE and WEST (P < 0.05) and WEST compared with BASE (P < 0.05). Long-haul transmeridian travel can impede team sport physical performance. Specifically, east travel has a greater detrimental effect on sleep, subjective jet lag, fatigue, and motivation. Consequently, maximal and intermittent sprint performance is also reduced after east travel, particularly within 72 h after arrival.

  7. The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Jennifer; Shen, Yue; Horne, Keith

    We present composite broad-line region (BLR) reverberation mapping lag measurements for H α , H β , He ii λ 4686, and Mg ii for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for H α ) and ∼0.65 (for the other lines). At similar quasar luminositiesmore » and redshifts, the sample-averaged lag decreases in the order of Mg ii, H α , H β , and He ii. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, H α shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size–luminosity relation based on H β . The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.« less

  8. The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

    NASA Astrophysics Data System (ADS)

    Li, Jennifer; Shen, Yue; Horne, Keith; Brandt, W. N.; Greene, Jenny E.; Grier, C. J.; Ho, Luis C.; Kochanek, Chris; Schneider, Donald P.; Trump, Jonathan R.; Dawson, Kyle S.; Pan, Kaike; Bizyaev, Dmitry; Oravetz, Daniel; Simmons, Audrey; Malanushenko, Elena

    2017-09-01

    We present composite broad-line region (BLR) reverberation mapping lag measurements for Hα, Hβ, He II λ4686, and Mg II for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for Hα) and ˜0.65 (for the other lines). At similar quasar luminosities and redshifts, the sample-averaged lag decreases in the order of Mg II, Hα, Hβ, and He II. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, Hα shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size-luminosity relation based on Hβ. The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.

  9. Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.

    PubMed

    Vithani, Kapilkumar; Hawley, Adrian; Jannin, Vincent; Pouton, Colin; Boyd, Ben J

    2017-05-01

    Solid self-microemulsifying drug delivery systems (SMEDDS) have received considerable attention in recent times attempting to overcome the drawbacks of liquid SMEDDS. Earlier literature reports on solid SMEDDS have focussed on formulation development; however, the digestibility and propensity for self-assembly of the digested components with endogenous bile salts and phospholipids are unknown. Therefore, as a starting point, previously reported solid SMEDDS containing Gelucire® 44/14 (GEL) and the non-digestible surfactants, Vitamin E TPGS (TPGS) and Lutrol® F 127 (F 127), were prepared, and their dispersion and digestion behaviours were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time. GEL alone was digested (89%) and formed a lamellar phase (Lα). When surfactants were added at a 40:60% w/w lipid to surfactants ratio, digestion was inhibited with a significant lag time being evident. However, increasing the fraction of GEL to 50% w/w enabled digestion with reduced lag time. The substitution of the non-digestible surfactants with digestible surfactants, sucrose esters S-1670 (S-1670) and Span® 60 (S-60), eliminated the digestion lag time, and the formation of colloidal structures was more similar to that of GEL alone.

  10. Lagging adaptation to warming climate in Arabidopsis thaliana.

    PubMed

    Wilczek, Amity M; Cooper, Martha D; Korves, Tonia M; Schmitt, Johanna

    2014-06-03

    If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer climates will outperform natives and may provide genetic potential for evolutionary rescue. We tested for lagging adaptation to warming climate using banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species' native European range: Valencia, Spain; Norwich, United Kingdom; Halle, Germany; and Oulu, Finland. Genotypes originating from geographic regions near the planting site had high relative fitness in each site, direct evidence for broad-scale geographic adaptation in this model species. However, genotypes originating in sites historically warmer than the planting site had higher average relative fitness than local genotypes in every site, especially at the northern range limit in Finland. This result suggests that local adaptive optima have shifted rapidly with recent warming across the species' native range. Climatic optima also differed among seasonal germination cohorts within the Norwich site, suggesting that populations occurring where summer germination is common may have greater evolutionary potential to persist under future warming. If adaptational lag has occurred over just a few decades in banked seeds of an annual species, it may be an important consideration for managing longer-lived species, as well as for attempts to conserve threatened populations through ex situ preservation.

  11. Lagging adaptation to warming climate in Arabidopsis thaliana

    PubMed Central

    Wilczek, Amity M.; Cooper, Martha D.; Korves, Tonia M.; Schmitt, Johanna

    2014-01-01

    If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer climates will outperform natives and may provide genetic potential for evolutionary rescue. We tested for lagging adaptation to warming climate using banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species’ native European range: Valencia, Spain; Norwich, United Kingdom; Halle, Germany; and Oulu, Finland. Genotypes originating from geographic regions near the planting site had high relative fitness in each site, direct evidence for broad-scale geographic adaptation in this model species. However, genotypes originating in sites historically warmer than the planting site had higher average relative fitness than local genotypes in every site, especially at the northern range limit in Finland. This result suggests that local adaptive optima have shifted rapidly with recent warming across the species’ native range. Climatic optima also differed among seasonal germination cohorts within the Norwich site, suggesting that populations occurring where summer germination is common may have greater evolutionary potential to persist under future warming. If adaptational lag has occurred over just a few decades in banked seeds of an annual species, it may be an important consideration for managing longer-lived species, as well as for attempts to conserve threatened populations through ex situ preservation. PMID:24843140

  12. Calibration of Watershed Lag Time Equation for Philippine Hydrology using RADARSAT Digital Elevation Models

    NASA Astrophysics Data System (ADS)

    Cipriano, F. R.; Lagmay, A. M. A.; Horritt, M.; Mendoza, J.; Sabio, G.; Punay, K. N.; Taniza, H. J.; Uichanco, C.

    2015-12-01

    Widespread flooding is a major problem in the Philippines. The country experiences heavy amount of rainfall throughout the year and several areas are prone to flood hazards because of its unique topography. Human casualties and destruction of infrastructure are just some of the damages caused by flooding and the Philippine government has undertaken various efforts to mitigate these hazards. One of the solutions was to create flood hazard maps of different floodplains and use them to predict the possible catastrophic results of different rain scenarios. To produce these maps with accurate output, different input parameters were needed and one of those is calculating hydrological components from topographical data. This paper presents how a calibrated lag time (TL) equation was obtained using measurable catchment parameters. Lag time is an essential input in flood mapping and is defined as the duration between the peak rainfall and peak discharge of the watershed. The lag time equation involves three measurable parameters, namely, watershed length (L), maximum potential retention (S) derived from the curve number, and watershed slope (Y), all of which were available from RADARSAT Digital Elevation Models (DEM). This approach was based on a similar method developed by CH2M Hill and Horritt for Taiwan, which has a similar set of meteorological and hydrological parameters with the Philippines. Rainfall data from fourteen water level sensors covering 67 storms from all the regions in the country were used to estimate the actual lag time. These sensors were chosen by using a screening process that considers the distance of the sensors from the sea, the availability of recorded data, and the catchment size. The actual lag time values were plotted against the values obtained from the Natural Resource Conservation Management handbook lag time equation. Regression analysis was used to obtain the final calibrated equation that would be used to calculate the lag time

  13. Striving for Student Success: A Model of Shared Accountability. Education Sector Reports

    ERIC Educational Resources Information Center

    Bathgate, Kelly; Colvin, Richard Lee; Silva, Elena

    2011-01-01

    Instead of putting the entire achievement burden on schools, what would it look like to hold a whole community responsible for long-range student outcomes? This report explores the concept of "shared accountability" in education. The No Child Left Behind (NCLB) Act ushered in a new era of accountability in American education: for the…

  14. 78 FR 66041 - 60-Day Notice of Proposed Information Collection: Multifamily Project Monthly Accounting Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5687-N-39] 60-Day Notice of Proposed Information Collection: Multifamily Project Monthly Accounting Reports AGENCY: Office of the Assistant... Collection: Multifamily Project Monthly Accounting Reports. OMB Approval Number: 2502-0108. Type of Request...

  15. Temporal evolution of photon energy emitted from two-component advective flows: origin of time lag

    NASA Astrophysics Data System (ADS)

    Chatterjee, Arka; Chakrabarti, Sandip K.; Ghosh, Himadri

    2017-12-01

    X-ray time lag of black hole candidates contains important information regarding the emission geometry. Recently, study of time lags from observational data revealed very intriguing properties. To investigate the real cause of this lag behavior with energy and spectral states, we study photon paths inside a two-component advective flow (TCAF) which appears to be a satisfactory model to explain the spectral and timing properties. We employ the Monte Carlo simulation technique to carry out the Comptonization process. We use a relativistic thick disk in Schwarzschild geometry as the CENtrifugal pressure supported BOundary Layer (CENBOL) which is the Compton cloud. In TCAF, this is the post-shock region of the advective component. Keplerian disk on the equatorial plane which is truncated at the inner edge i.e. at the outer boundary of the CENBOL, acts as the soft photon source. Ray-tracing code is employed to track the photons to a distantly located observer. We compute the cumulative time taken by a photon during Comptonization, reflection and following the curved geometry on the way to the observer. Time lags between various hard and soft bands have been calculated. We study the variation of time lags with accretion rates, CENBOL size and inclination angle. Time lags for different energy channels are plotted for different inclination angles. The general trend of variation of time lag with QPO frequency and energy as observed in satellite data is reproduced.

  16. Extensions to the time lag models for practical application to rocket engine stability design

    NASA Astrophysics Data System (ADS)

    Casiano, Matthew J.

    models. This new feature shows that the injector boundary can play a significant role for combustion stability, especially for gaseous injection systems or a system with an injector orifice on the order of the size of the chamber. The second new model additionally accounts for resistive effects. Advanced signal analysis techniques are used to extract frequency-dependent damping from a gas generator component data set. The damping values are then used in the new stability model to more accurately represent the chamber response of the component. The results show a more realistic representation of stability margin by incorporating the appropriate damping effects into the chamber response from data. The original Crocco model, a contemporary model, and the two new models are all compared and contrasted to a marginally stable test case showing their applicability. The model that incorporates resistive aspects shows the best comparison to the test data. Parametrics are also examined to show the influence of the new features and their applicability. The new features allow a more accurate representation of stability margin to be obtained. The third new model is an extension to the Wenzel and Szuch double-time lag chug model. The feed system chug model is extended to account for generic propellant flow rates. This model is also extended to incorporate aspects due to oxygen boiling and helium injection in the feed system. The solutions to the classic models, for the single-time lag and the double-time lag models, are often plotted on a practical engine operating map, however the models have presented some difficulties for numerical algorithms for several reasons. Closed-form solutions for use on these practical operating maps are formulated and developed. These models are incorporated in a graphical user interface tool and the new model is compared to an extensive data set. It correctly predicts the stability behavior at various operating conditions incorporating the influence of

  17. U.S. Department of Education FY 2003 Performance and Accountability Report.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This is a report on the progress of the U.S. Department of Education's accounting systems and management controls. Sections include: (1) Management's Discussion and Analysis; (2) Performance Details; (3) Financial Details; and (4) Other Statutorily Required Reports. Five appendixes are included along with a glossary of terms and a list of figures.…

  18. Accounting for inherent variability of growth in microbial risk assessment.

    PubMed

    Marks, H M; Coleman, M E

    2005-04-15

    Risk assessments of pathogens need to account for the growth of small number of cells under varying conditions. In order to determine the possible risks that occur when there are small numbers of cells, stochastic models of growth are needed that would capture the distribution of the number of cells over replicate trials of the same scenario or environmental conditions. This paper provides a simple stochastic growth model, accounting only for inherent cell-growth variability, assuming constant growth kinetic parameters, for an initial, small, numbers of cells assumed to be transforming from a stationary to an exponential phase. Two, basic, microbial sets of assumptions are considered: serial, where it is assume that cells transform through a lag phase before entering the exponential phase of growth; and parallel, where it is assumed that lag and exponential phases develop in parallel. The model is based on, first determining the distribution of the time when growth commences, and then modelling the conditional distribution of the number of cells. For the latter distribution, it is found that a Weibull distribution provides a simple approximation to the conditional distribution of the relative growth, so that the model developed in this paper can be easily implemented in risk assessments using commercial software packages.

  19. On the time lags of the LIGO signals

    NASA Astrophysics Data System (ADS)

    Creswell, James; von Hausegger, Sebastian; Jackson, Andrew D.; Liu, Hao; Naselsky, Pavel

    2017-08-01

    To date, the LIGO collaboration has detected three gravitational wave (GW) events appearing in both its Hanford and Livingston detectors. In this article we reexamine the LIGO data with regard to correlations between the two detectors. With special focus on GW150914, we report correlations in the detector noise which, at the time of the event, happen to be maximized for the same time lag as that found for the event itself. Specifically, we analyze correlations in the calibration lines in the vicinity of 35 Hz as well as the residual noise in the data after subtraction of the best-fit theoretical templates. The residual noise for the other two events, GW151226 and GW170104, exhibits similar behavior. A clear distinction between signal and noise therefore remains to be established in order to determine the contribution of gravitational waves to the detected signals.

  20. On the time lags of the LIGO signals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Creswell, James; Von Hausegger, Sebastian; Liu, Hao

    To date, the LIGO collaboration has detected three gravitational wave (GW) events appearing in both its Hanford and Livingston detectors. In this article we reexamine the LIGO data with regard to correlations between the two detectors. With special focus on GW150914, we report correlations in the detector noise which, at the time of the event, happen to be maximized for the same time lag as that found for the event itself. Specifically, we analyze correlations in the calibration lines in the vicinity of 35 Hz as well as the residual noise in the data after subtraction of the best-fit theoreticalmore » templates. The residual noise for the other two events, GW151226 and GW170104, exhibits similar behavior. A clear distinction between signal and noise therefore remains to be established in order to determine the contribution of gravitational waves to the detected signals.« less

  1. The accountability of nonprofit hospitals: lessons from Maryland's community benefit reporting requirements.

    PubMed

    Gray, Bradford H; Schlesinger, Mark

    2009-01-01

    Under Internal Revenue Service requirements, nonprofit hospitals will begin filing new community benefit reports in 2010. Maryland has had similar requirements since 2004. This paper, based on interviews at 20 hospitals, describes how Maryland's requirements affected hospitals and their activities. Increases in reported community benefit expenditures since the program began are due to both changes in activities and better data capture. Charity care accounts for one-third of community benefit dollars. A key distinction concerns whether hospitals take an accounting or managerial approach to community benefit. The Maryland experience suggests the issues that will arise when the national requirements are implemented.

  2. Repetition-lag training to improve recollection memory in older people with amnestic mild cognitive impairment. A randomized controlled trial.

    PubMed

    Finn, Maurice; McDonald, Skye

    2015-01-01

    The results of a randomized controlled trial of repetition-lag training in older adults with amnestic mild cognitive impairment (aMCI) are reported. A modified repetition-lag training procedure with extended encoding time and strategy choice was used. The training required discriminating studied words from non-studied lures that were repeated at varying intervals during the test phase. Participants were assessed pre/post using untrained measures of cognition and self-report questionnaires. Primary outcome measures were recall of unrelated word pairs both immediately following presentation and following a delay. Secondary outcomes were a measure of attention, cognitive flexibility, and visual working memory. Participants were also asked to report on the frequency of cognitive failures and mood before and after training. Participants (N = 31) were randomized into either the treatment or a no-contact control group and attended the clinic twice per week over a four week period. Twenty-four participants completed the study (twelve in each group). Results indicated that the training group improved at recalling unrelated word pairs after a delay. There were no significant effects of training on other outcomes, self-reported cognitive failures or mood. The results are discussed along with suggestions for future research.

  3. ON THE ORIGIN OF THE {gamma}-RAY/OPTICAL LAGS IN LUMINOUS BLAZARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Janiak, Mateusz; Sikora, Marek; Moderski, Rafal

    2012-12-01

    Blazars are strongly variable sources that occasionally show spectacular flares visible in various energy bands. These flares are often, but not always, correlated. In a number of cases, the peaks of optical flares are found to be somewhat delayed with respect to the {gamma}-ray peaks. One notable example of such a delay was found in 3C 279 by Hayashida et al. and interpreted as a result of steeper drop with a distance of the energy density of an external radiation field than of the magnetic energy density. In this paper, we demonstrate that, in general, depending on the respective energymore » density profile along the jet, such lags can have both signs and that they can take place for any ratio of these energy densities. We study the dependence of such lags on the ratio of these energy densities at a distance of a maximal energy dissipation in a jet, on their gradients, as well as on the time profile of the relativistic electron injection within the moving source. We show how prominent such lags can be, and their expected timescales. We suggest that studies of such lags can provide a powerful tool to resolve the structure of relativistic jets and their radiative environment. As an example we model the lag observed in 3C 279, showing that in this object the flare is produced at a distance of a few parsecs from the central black hole, consistent with our previous inferences based on the spectra and optical polarization properties.« less

  4. Assessing delay and lag in sagittal trunk control using a tracking task.

    PubMed

    Reeves, N Peter; Luis, Abraham; Chan, Elizabeth C; Sal Y Rosas, Victor G; Tanaka, Martin L

    2018-05-17

    Slower trunk muscle responses are linked to back pain and injury. Unfortunately, clinical assessments of spine function do not objectively evaluate this important attribute, which reflects speed of trunk control. Speed of trunk control can be parsed into two components: (1) delay, the time it takes to initiate a movement, and (2) lag, the time it takes to execute a movement once initiated. The goal of this study is to demonstrate a new approach to assess delay and lag in trunk control using a simple tracking task. Ten healthy subjects performed four blocks of six trials of trunk tracking in the sagittal plane. Delay and lag were estimated by modeling trunk control for predictable and unpredictable (control mode) trunk movements in flexion and extension (control direction) at movement amplitudes of 2°, 4°, and 6° (control amplitude). The main effect of control mode, direction, and amplitude of movement were compared between trial blocks to assess secondary influencers (e.g., fatigue). Only control mode was consistent across trial blocks with predictable movements being faster than unpredictable for both delay and lag. Control direction and amplitude effects on delay and lag were consistent across the first two trial blocks and less consistent in later blocks. Given the heterogeneity in the presentation of back pain, clinical assessment of trunk control should include different control modes, directions, and amplitudes. To reduce testing time and the influence of fatigue, we recommend six trials to assess trunk control. Copyright © 2018 Elsevier Ltd. All rights reserved.

  5. National Aeronautics and Space Administration FY 2001 Accountability Report

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The National Aeronautics and Space Administration (NASA) is an independent Agency established to plan and manage the future of the Nation's civil aeronautics and space program. This Accountability Report covers Federal Fiscal Year (FY) 2001 (October 1, 2000, through September 30, 2001), with discussion of some subsequent events The Report contains an overview addressing the Agency's critical programs and financial performance and includes highlights of performance organized by goals and objectives of the Enterprises and Crosscutting Processes. The Report also summarizes NASA's stewardship over budget and financial resources, including audited financial statements and footnotes. The financial statements reflect an overall position of offices and activities, including assets and liabilities, as well as results of operations, pursuant to requirements of Federal law (31 U.S.C. 3515(b)). The auditor's opinions on NASA's financial statements, reports on internal controls, and compliance with laws and regulations are included in this Report.

  6. Consequences of varied soil hydraulic and meteorological complexity on unsaturated zone time lag estimates.

    PubMed

    Vero, S E; Ibrahim, T G; Creamer, R E; Grant, J; Healy, M G; Henry, T; Kramers, G; Richards, K G; Fenton, O

    2014-12-01

    The true efficacy of a programme of agricultural mitigation measures within a catchment to improve water quality can be determined only after a certain hydrologic time lag period (subsequent to implementation) has elapsed. As the biophysical response to policy is not synchronous, accurate estimates of total time lag (unsaturated and saturated) become critical to manage the expectations of policy makers. The estimation of the vertical unsaturated zone component of time lag is vital as it indicates early trends (initial breakthrough), bulk (centre of mass) and total (Exit) travel times. Typically, estimation of time lag through the unsaturated zone is poor, due to the lack of site specific soil physical data, or by assuming saturated conditions. Numerical models (e.g. Hydrus 1D) enable estimates of time lag with varied levels of input data. The current study examines the consequences of varied soil hydraulic and meteorological complexity on unsaturated zone time lag estimates using simulated and actual soil profiles. Results indicated that: greater temporal resolution (from daily to hourly) of meteorological data was more critical as the saturated hydraulic conductivity of the soil decreased; high clay content soils failed to converge reflecting prevalence of lateral component as a contaminant pathway; elucidation of soil hydraulic properties was influenced by the complexity of soil physical data employed (textural menu, ROSETTA, full and partial soil water characteristic curves), which consequently affected time lag ranges; as the importance of the unsaturated zone increases with respect to total travel times the requirements for high complexity/resolution input data become greater. The methodology presented herein demonstrates that decisions made regarding input data and landscape position will have consequences for the estimated range of vertical travel times. Insufficiencies or inaccuracies regarding such input data can therefore mislead policy makers regarding

  7. Customizing Extensor Reconstruction in Vascularized Toe Joint Transfers to Finger Proximal Interphalangeal Joints: A Strategic Approach for Correcting Extensor Lag.

    PubMed

    Loh, Charles Yuen Yung; Hsu, Chung-Chen; Lin, Cheng-Hung; Chen, Shih-Heng; Lien, Shwu-Huei; Lin, Chih-Hung; Wei, Fu-Chan; Lin, Yu-Te

    2017-04-01

    Vascularized toe proximal interphalangeal joint transfer allows the restoration of damaged joints. However, extensor lag and poor arc of motion have been reported. The authors present their outcomes of treatment according to a novel reconstructive algorithm that addresses extensor lag and allows for consistent results postoperatively. Vascularized toe joint transfers were performed in a consecutive series of 26 digits in 25 patients. The average age was 30.5 years, with 14 right and 12 left hands. Reconstructed digits included eight index, 10 middle, and eight ring fingers. Simultaneous extensor reconstructions were performed and eight were centralization of lateral bands, five were direct extensor digitorum longus-to-extensor digitorum communis repairs, and 13 were central slip reconstructions. The average length of follow-up was 16.7 months. The average extension lag was 17.9 degrees. The arc of motion was 57.7 degrees (81.7 percent functional use of pretransfer toe proximal interphalangeal joint arc of motion). There was no significant difference in the reconstructed proximal interphalangeal joint arc of motion for the handedness (p = 0.23), recipient digits (p = 0.37), or surgical experience in vascularized toe joint transfer (p = 0.25). The outcomes of different techniques of extensor mechanism reconstruction were similar in terms of extensor lag, arc of motion, and reconstructed finger arc of motion compared with the pretransfer toe proximal interphalangeal joint arc of motion. With this treatment algorithm, consistent outcomes can be produced with minimal extensor lag and maximum use of potential toe proximal interphalangeal joint arc of motion. Therapeutic, IV.

  8. Accretion Disk Reverberation with Hubble Space Telescope Observations of NGC 4593: Evidence for Diffuse Continuum Lags

    NASA Astrophysics Data System (ADS)

    Cackett, Edward M.; Chiang, Chia-Ying; McHardy, Ian; Edelson, Rick; Goad, Michael R.; Horne, Keith; Korista, Kirk T.

    2018-04-01

    The Seyfert 1 galaxy NGC 4593 was monitored spectroscopically with the Hubble Space Telescope as part of a reverberation mapping campaign that also included Swift, Kepler, and ground-based photometric monitoring. During 2016 July 12–August 6, we obtained 26 spectra across a nearly continuous wavelength range of ∼1150–10000 Å. These were combined with Swift data to produce a UV/optical “lag spectrum,” which shows the interband lag relative to the Swift UVW2 band as a function of wavelength. The broad shape of the lag spectrum appears to follow the τ ∝ λ 4/3 relation seen previously in photometric interband lag measurements of other active galactic nuclei (AGNs). This shape is consistent with the standard thin disk model, but the magnitude of the lags implies a disk that is a factor of ∼3 larger than predicted, again consistent with what has been previously seen in other AGNs. In all cases these large disk sizes, which are also implied by independent gravitational microlensing of higher-mass AGNs, cannot be simply reconciled with the standard model. However, the most striking feature in this higher-resolution lag spectrum is a clear excess around the 3646 Å Balmer jump. This strongly suggests that diffuse emission from gas in the much larger broad-line region (BLR) must also contribute significantly to the interband lags. While the relative contributions of the disk and BLR cannot be uniquely determined in these initial measurements, it is clear that both will need to be considered to comprehensively model and understand AGN lag spectra.

  9. Urban mass transportation industry uniform system of accounts and records and reporting system. Volume II. Uniform system of accounts and records.

    DOT National Transportation Integrated Search

    1977-01-10

    The purpose of the report is to present and document the detailed features of the uniform system of accounts and records and reporting system required by Section 15 of the Urban Mass Transportation Act of 1964, as amended. Volume 2 contains the defin...

  10. Does the benefit of testing depend on lag, and if so, why? Evaluating the elaborative retrieval hypothesis.

    PubMed

    Rawson, Katherine A; Vaughn, Kalif E; Carpenter, Shana K

    2015-05-01

    Despite the voluminous literatures on testing effects and lag effects, surprisingly few studies have examined whether testing and lag effects interact, and no prior research has directly investigated why this might be the case. To this end, in the present research we evaluated the elaborative retrieval hypothesis (ERH) as a possible explanation for why testing effects depend on lag. Elaborative retrieval involves the activation of cue-related information during the long-term memory search for the target. If the target is successfully retrieved, this additional information is encoded with the cue-target pair to yield a more elaborated memory trace that enhances target access on a later memory test. The ERH states that the degree of elaborative retrieval during practice is greater when testing takes place after a long rather than a short lag (whereas elaborative retrieval during restudy is minimal at either lag). Across two experiments, final-test performance was greater following practice testing than following restudy only, and this memorial advantage was greater with long-lag than with short-lag practice. The final test also included novel cue conditions used to diagnose the degree of elaborative retrieval during practice. The overall pattern of performance in these conditions provided consistent evidence for the ERH, with more extensive elaborative retrieval during long- than during short-lag practice testing.

  11. DOD SCHOOLS: Additional Reporting Could Improve Accountability for Academic Achievement of Students with Dyslexia

    DTIC Science & Technology

    2007-12-01

    Representatives DOD SCHOOLS Additional Reporting Could Improve Accountability for Academic Achievement of Students with Dyslexia December...Could Improve Accountability for Academic Achievement of Students with Dyslexia 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Students with Dyslexia Highlights of GAO-08-70, a report to the Chairman, Committee on Science and Technology, House of Representatives Many of our

  12. Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum

    ERIC Educational Resources Information Center

    Owen, Gareth

    2013-01-01

    Integrated reporting (IR) is a major development in a number of sustainability-related accounting initiatives and, if widely adopted, will require significant developments in professional and university accounting curricula. These will include: a strategic rather than operational or transactional focus; longer- rather than short-term outlook;…

  13. Function and regulation of LAG3 on CD4+CD25- T cells in non-small cell lung cancer.

    PubMed

    Ma, Qin-Yun; Huang, Da-Yu; Zhang, Hui-Jun; Wang, Shaohua; Chen, Xiao-Feng

    2017-11-15

    LAG3 is a surface molecule found on a subset of immune cells. The precise function of LAG3 appears to be context-dependent. In this study, we investigated the effect of LAG3 on CD4 + CD25 - T cells from non-small cell lung cancer (NSCLC) patients. We found that in the peripheral blood mononuclear cells of NSCLC patients, LAG3 was significantly increased in CD4 + T cells directly ex vivo and primarily in the CD4 + CD25 - fraction, which was regulated by prolonged TCR stimulation and the presence of IL-27. TCR stimulation also increased CD25 expression, but not Foxp3 expression, in LAG3-expressing CD4 + CD25 - cells Compared to LAG3-nonexpressing CD4 + CD25 - cells, LAG3-expressing CD4 + CD25 - cells presented significantly higher levels of PD1 and TIM3, two inhibitory receptors best described in exhausted CD8 + T effector cells. LAG3-expressing CD4 + CD25 - cells also presented impaired proliferation compared with LAG3-nonexpressing CD4 + CD25 - cells but could be partially rescued by inhibiting both PD1 and TIM3. Interestingly, CD8 + T cells co-incubated with LAG3-expressing CD4 + CD25 - cells at equal cell numbers demonstrated significantly lower proliferation than CD8 + T cells incubated alone. Co-culture with CD8 + T cell and LAG3-expressing CD4 + CD25 - T cell also upregulated soluble IL-10 level in the supernatant, of which the concentration was positively correlated with the number of LAG3-expressing CD4 + CD25 - T cells. In addition, we found that LAG3-expressing CD4 + CD25 - T cells infiltrated the resected tumors and were present at higher frequencies of in metastases than in primary tumors. Taken together, these data suggest that LAG3-expressing CD4 + CD25 - T cells represent another regulatory immune cell type with potential to interfere with anti-tumor immunity. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. The influence of interactions between accommodation and convergence on the lag of accommodation.

    PubMed

    Schor, C

    1999-03-01

    Several models of myopia predict that growth of axial length is stimulated by blur. Accommodative lag has been suggested as an important source of blur in the development of myopia and this study has modeled how cross-link interactions between accommodation and convergence might interact with uncorrected distance heterophoria and refractive error to influence accommodative lag. Accommodative lag was simulated with two models of interactions between accommodation and convergence (one with and one without adaptable tonic elements). Simulations of both models indicate that both uncorrected hyperopia and esophoria increase the lag of accommodative and uncorrected myopia and exophoria decrease the lag or introduce a lead of accommodation in response to the near (40 cm) stimulus. These effects were increased when gain of either cross-link, accommodative convergence (AC/A) or convergence accommodation (CA/C), was increased within a moderate range of values while the other was fixed at a normal value (clamped condition). These effects were exaggerated when both the AC/A and CA/C ratios were increased (covaried condition) and affects of cross-link gain were negated when an increase of one cross-link (e.g. AC/A) was accompanied by a reduction of the other cross-link (e.g. CA/C) (reciprocal condition). The inclusion of tonic adaptation in the model reduced steady state errors of accommodation for all conditions except when the AC/A ratio was very high (2 MA/D). Combinations of cross-link interactions between accommodation and convergence that resemble either clamped or reciprocal patterns occur naturally in clinical populations. Simulations suggest that these two patterns of abnormal cross-link interactions could affect the progression of myopia differently. Adaptable tonic accommodation and tonic vergence could potentially reduce the progression of myopia by reducing the lag of accommodation.

  15. Increasing Vocal Variability in Children with Autism Using a Lag Schedule of Reinforcement

    ERIC Educational Resources Information Center

    Esch, John W.; Esch, Barbara E.; Love, Jessa R.

    2009-01-01

    Variability has been demonstrated to be an operant dimension of behavior (Neuringer, 2002; Page & Neuringer, 1985). Recently, lag schedules have been used to demonstrate operant variability of verbal behavior in persons with a diagnosis of autism (e.g., Lee, McComas, & Jawor, 2002). The current study evaluated the effects of a Lag 1 schedule on…

  16. Investigation of Co-rotation Lag in Saturn's Dayside Magnetosphere and Comparison with the Nightside

    NASA Astrophysics Data System (ADS)

    Smith, E. J.; Dougherty, M. K.

    2016-12-01

    Two previous studies of co-rotation lag concentrated on 13 identical high-inclination Cassini orbits. In the first, measurements of the magnetospheric field azimuthal component, Bϕ, were restricted to the southern hemisphere, near midnight, from the equator and perikron to maximum latitude 70°. Comparison with the prevailing model of the magnetosphere-ionosphere interaction yielded conclusions that the ionospheric conductivity, Σp, was independent of ionospheric co-latitude, θi, and the ratio of magnetospheric to planetary field angular velocities, ω/Ωs, equaled, 1- exp(-Bθi), an unexpected exponential dependence on a single parameter. Both model parameters exhibited significant temporal variations from orbit to orbit leading to variations in the ionospheric profiles of Pedersen current, Ip. The second 13 orbit study of Bϕ extended to the north hemisphere where lagging fields alternated with leading and co-rotating fields. It was concluded that the difference was actually a local- time dependence with lagging -fields- only occurring after midnight and the mixed rotations before midnight. Again, Σp was independent of θi and ω/Ωs = 1- exp(-Bθi). Both studies raised the questions: How general is the exponential dependence of 1-ω/Ωs? Is it restricted to midnight or hold as well in the dayside magnetosphere? What is the cause of this dependence that differs from the model? The analysis of Bϕ has been extended to four nearly-identical north-south orbits near noon. The results and conclusions of this third study will be reported.

  17. A comparison of alternative variants of the lead and lag time TTO.

    PubMed

    Devlin, Nancy; Buckingham, Ken; Shah, Koonal; Tsuchiya, Aki; Tilling, Carl; Wilkinson, Grahame; van Hout, Ben

    2013-05-01

    'Lead Time' TTO improves upon conventional TTO by providing a uniform method for eliciting positive and negative values. This research investigates (i) the values generated from different combinations of time in poor health and in full health; and the order in which these appear (lead vs. lag); (ii) whether values concur with participants' views about states; (iii) methods for handling extreme preferences. n = 208 participants valued five EQ-5D states, using two of four variants. Combinations of lead time and health state duration were: 10 years and 20 years; 5 years and 1 year; 5 years and 10 years; and a health state duration of 5 years with a lag time of 10 years. Longer lead times capture more preferences, but may involve a framing effect. Lag time results in less non-trading for mild states, and less time being traded for severe states. Negative values broadly agree with participants' stated opinion that the state is worse than dead. The values are sensitive to the ratio of lead time to duration of poor health, and the order in which these appear (lead vs. lag). It is feasible to handle extreme preferences though challenges remain. Copyright © 2012 John Wiley & Sons, Ltd.

  18. Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability.

    PubMed

    Maddox, Brenna B; Cleary, Patrick; Kuschner, Emily S; Miller, Judith S; Armour, Anna Chelsea; Guy, Lisa; Kenworthy, Lauren; Schultz, Robert T; Yerys, Benjamin E

    2017-08-01

    Many children with autism spectrum disorder display challenging behaviors. These behaviors are not limited to those with cognitive and/or language impairments. The Collaborative and Proactive Solutions framework proposes that challenging behaviors result from an incompatibility between environmental demands and a child's "lagging skills." The primary Collaborative and Proactive Solutions lagging skills-executive function, emotion regulation, language, and social skills-are often areas of weakness for individuals with autism spectrum disorder. The purpose of this study was to evaluate whether these lagging skills are associated with challenging behaviors in youth with autism spectrum disorder without intellectual disability. Parents of 182 youth with autism spectrum disorder (6-15 years) completed measures of their children's challenging behaviors, executive function, language, emotion regulation, and social skills. We tested whether the Collaborative and Proactive Solutions lagging skills predicted challenging behaviors using multiple linear regression. The Collaborative and Proactive Solutions lagging skills explained significant variance in participants' challenging behaviors. The Depression (emotion regulation), Inhibit (executive function), and Sameness (executive function) scales emerged as significant predictors. Impairments in emotion regulation and executive function may contribute substantially to aggressive and oppositional behaviors in school-age youth with autism spectrum disorder without intellectual disability. Treatment for challenging behaviors in this group may consider targeting the incompatibility between environmental demands and a child's lagging skills.

  19. Current Status of Biomedical Book Reviewing: Part II. Time Lag in Biomedical Book Reviewing

    PubMed Central

    Chen, Ching-Chih

    1974-01-01

    This part of the study explores the effectiveness of the review media in terms of speed of reviewing, comprehensiveness of review treatment, and authority. The time lags for the fifty-four journals varied widely, the mean ranging from 5.8 months to forty-two months. The time lags for all 3,347 reviews varied even more widely, ranging from less than a month to 108 months after a book was off the press. The 3,347 reviews had a mean time lag of 10.43 months and a standard deviation of 6.63 months. PMID:4826480

  20. 42 CFR 35.63 - Report of and accounting for contributions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Report of and accounting for contributions. 35.63 Section 35.63 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT Contributions for the Benefit of Patients § 35.63...

  1. 42 CFR 35.63 - Report of and accounting for contributions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Report of and accounting for contributions. 35.63 Section 35.63 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT Contributions for the Benefit of Patients § 35.63...

  2. 42 CFR 35.63 - Report of and accounting for contributions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Report of and accounting for contributions. 35.63 Section 35.63 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT Contributions for the Benefit of Patients § 35.63...

  3. 42 CFR 35.63 - Report of and accounting for contributions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Report of and accounting for contributions. 35.63 Section 35.63 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT Contributions for the Benefit of Patients § 35.63...

  4. A Guide to Effective Accountability Reporting: Designing Public Reports that Effectively Communicate Accountability, Assessment and Other Quantitative Education Indicators in an Easily Understood Format.

    ERIC Educational Resources Information Center

    Fast, Ellen Forte

    This guide was developed to serve as a resource for the staffs of state education agencies and local education agencies who are responsible for producing state, district, or school report cards of the type required under many state or district accountability systems as well as under the No Child Left Behind Act (NCLB). The guide is not intended to…

  5. DNA-directed mutations. Leading and lagging strand specificity

    NASA Technical Reports Server (NTRS)

    Sinden, R. R.; Hashem, V. I.; Rosche, W. A.

    1999-01-01

    The fidelity of replication has evolved to reproduce B-form DNA accurately, while allowing a low frequency of mutation. The fidelity of replication can be compromised, however, by defined order sequence DNA (dosDNA) that can adopt unusual or non B-DNA conformations. These alternative DNA conformations, including hairpins, cruciforms, triplex DNAs, and slipped-strand structures, may affect enzyme-template interactions that potentially lead to mutations. To analyze the effect of dosDNA elements on spontaneous mutagenesis, various mutational inserts containing inverted repeats or direct repeats were cloned in a plasmid containing a unidirectional origin of replication and a selectable marker for the mutation. This system allows for analysis of mutational events that are specific for the leading or lagging strands during DNA replication in Escherichia coli. Deletions between direct repeats, involving misalignment stabilized by DNA secondary structure, occurred preferentially on the lagging strand. Intermolecular strand switch events, correcting quasipalindromes to perfect inverted repeats, occurred preferentially during replication of the leading strand.

  6. Reverse Flood Routing with the Lag-and-Route Storage Model

    NASA Astrophysics Data System (ADS)

    Mazi, K.; Koussis, A. D.

    2010-09-01

    This work presents a method for reverse routing of flood waves in open channels, which is an inverse problem of the signal identification type. Inflow determination from outflow measurements is useful in hydrologic forensics and in optimal reservoir control, but has been seldom studied. Such problems are ill posed and their solution is sensitive to small perturbations present in the data, or to any related uncertainty. Therefore the major difficulty in solving this inverse problem consists in controlling the amplification of errors that inevitably befall flow measurements, from which the inflow signal is to be determined. The lag-and-route model offers a convenient framework for reverse routing, because not only is formal deconvolution not required, but also reverse routing is through a single linear reservoir. In addition, this inversion degenerates to calculating the intermediate inflow (prior to the lag step) simply as the sum of the outflow and of its time derivative multiplied by the reservoir’s time constant. The remaining time shifting (lag) of the intermediate, reversed flow presents no complications, as pure translation causes no error amplification. Note that reverse routing with the inverted Muskingum scheme (Koussis et al., submitted to the 12th Plinius Conference) fails when that scheme is specialised to the Kalinin-Miljukov model (linear reservoirs in series). The principal functioning of the reverse routing procedure was verified first with perfect field data (outflow hydrograph generated by forward routing of a known inflow hydrograph). The field data were then seeded with random error. To smooth the oscillations caused by the imperfect (measured) outflow data, we applied a multipoint Savitzky-Golay low-pass filter. The combination of reverse routing and filtering achieved an effective recovery of the inflow signal extremely efficiently. Specifically, we compared the reverse routing results of the inverted lag-and-route model and of the inverted

  7. Transport and time lag of chlorofluorocarbon gases in the unsaturated zone, Rabis Creek, Denmark

    USGS Publications Warehouse

    Engesgaard, Peter; Højberg, Anker L.; Hinsby, Klaus; Jensen, Karsten H.; Laier, Troels; Larsen, Flemming; Busenberg, Eurybiades; Plummer, Niel

    2004-01-01

    Transport of chlorofluorocarbon (CFC) gases through the unsaturated zone to the water table is affected by gas diffusion, air–water exchange (solubility), sorption to the soil matrix, advective–dispersive transport in the water phase, and, in some cases, anaerobic degradation. In deep unsaturated zones, this may lead to a time lag between entry of gases at the land surface and recharge to groundwater. Data from a Danish field site were used to investigate how time lag is affected by variations in water content and to explore the use of simple analytical solutions to calculate time lag. Numerical simulations demonstrate that either degradation or sorption of CFC-11 takes place, whereas CFC-12 and CFC-113 are nonreactive. Water flow did not appreciably affect transport. An analytical solution for the period with a linear increase in atmospheric CFC concentrations (approximately early 1970s to early 1990s) was used to calculate CFC profiles and time lags. We compared the analytical results with numerical simulations. The time lags in the 15-m-deep unsaturated zone increase from 4.2 to between 5.2 and 6.1 yr and from 3.4 to 3.9 yr for CFC-11 and CFC-12, respectively, when simulations change from use of an exponential to a linear increase in atmospheric concentrations. The CFC concentrations at the water table before the early 1990s can be estimated by displacing the atmospheric input function by these fixed time lags. A sensitivity study demonstrates conditions under which a time lag in the unsaturated zone becomes important. The most critical parameter is the tortuosity coefficient. The analytical approach is valid for the low range of tortuosity coefficients (τ = 0.1–0.4) and unsaturated zones greater than approximately 20 m in thickness. In these cases the CFC distribution may still be from either the exponential or linear phase. In other cases, the use of numerical models, as described in our work and elsewhere, is an option.

  8. How to Integrate International Financial Reporting Standards into Accounting Programs

    ERIC Educational Resources Information Center

    Singer, Robert A.

    2012-01-01

    It is expected the SEC will require U.S. domestic companies to prepare and file their annual 10Ks in accordance with international financial reporting standards (IFRS) by 2016. Given the probability that the FASB-IASB convergence project (i.e., Norwalk Agreement) will continue subsequent to mandatory adoption, US accounting programs will be…

  9. Social Indicators, Social Reports and Social Accounts: Toward the Management of Society.

    ERIC Educational Resources Information Center

    Springer, Michael

    This report examines the origins and implications of social reporting and accounting and defines the problems related to finding measurable indicators of social change. The development of scholarly and governmental interest in these concepts and the interest in the conceptual differences among approaches on how to manage society are discussed. In…

  10. Lagged correlation networks

    NASA Astrophysics Data System (ADS)

    Curme, Chester

    Technological advances have provided scientists with large high-dimensional datasets that describe the behaviors of complex systems: from the statistics of energy levels in complex quantum systems, to the time-dependent transcription of genes, to price fluctuations among assets in a financial market. In this environment, where it may be difficult to infer the joint distribution of the data, network science has flourished as a way to gain insight into the structure and organization of such systems by focusing on pairwise interactions. This work focuses on a particular setting, in which a system is described by multivariate time series data. We consider time-lagged correlations among elements in this system, in such a way that the measured interactions among elements are asymmetric. Finally, we allow these interactions to be characteristically weak, so that statistical uncertainties may be important to consider when inferring the structure of the system. We introduce a methodology for constructing statistically validated networks to describe such a system, extend the methodology to accommodate interactions with a periodic component, and show how consideration of bipartite community structures in these networks can aid in the construction of robust statistical models. An example of such a system is a financial market, in which high frequency returns data may be used to describe contagion, or the spreading of shocks in price among assets. These data provide the experimental testing ground for our methodology. We study NYSE data from both the present day and one decade ago, examine the time scales over which the validated lagged correlation networks exist, and relate differences in the topological properties of the networks to an increasing economic efficiency. We uncover daily periodicities in the validated interactions, and relate our findings to explanations of the Epps Effect, an empirical phenomenon of financial time series. We also study bipartite community

  11. [Complexity and its integrative effects of the time lags of environment factors affecting Larix gmelinii stem sap flow].

    PubMed

    Wang, Hui-Mei; Sun, Wei; Zu, Yuan-Gang; Wang, Wen-Jie

    2011-12-01

    Based on the one-year (2005) observations with a frequency of half hour on the stem sap flow of Larix gmelinii plantation trees planted in 1969 and the related environmental factors air humidity (RH), air temperature (T(air)), photosynthetic components active radiation (PAR), soil temperature (T(soil)), and soil moisture (TDR), principal analysis (PCA) and correction analysis were made on the time lag effect of the stem flow in different seasons (26 days of each season) and in a year via dislocation analysis, with the complexity and its integrative effects of the time lags of environment factors affecting the stem sap flow approached. The results showed that in different seasons and for different environmental factors, the time lag effect varied obviously. In general, the time lag of PAR was 0.5-1 hour ahead of sap flow, that of T(air) and RH was 0-2 hours ahead of or behind the sap flow, and the time lags of T(soil) and TDR were much longer or sometimes undetectable. Because of the complexity of the time lags, no evident improvements were observed in the linear correlations (R2, slope, and intercept) when the time lags based on short-term (20 days) data were used to correct the time lags based on whole year data. However, obvious improvements were found in the standardized and non-standardized correlation coefficients in stepwise multiple regressions, i.e., the time lag corrections could improve the effects of RH, but decreased the effects of PAR, T(air), and T(soil). PCA could be used to simplify the complexity. The first and the second principal components could stand for over 75% information of all the environmental factors in different seasons and in whole year. The time lags of both the first and the second principal components were 1-1.5 hours in advance of the sap flow, except in winter (no time lag effect).

  12. Time lags between crown and basal sap flows in tropical lianas and co-occurring trees.

    PubMed

    Chen, Ya-Jun; Bongers, Frans; Tomlinson, Kyle; Fan, Ze-Xin; Lin, Hua; Zhang, Shu-Bin; Zheng, Yu-Long; Li, Yang-Ping; Cao, Kun-Fang; Zhang, Jiao-Lin

    2016-06-01

    Water storage in the stems of woody plants contributes to their responses to short-term water shortages. To estimate the contribution of water storage to the daily water budget of trees, time lags of sap flow between different positions of trunk are used as a proxy of stem water storage. In lianas, another large group of woody species, it has rarely been studied whether stored water functions in their daily water use, despite their increasing roles in the carbon and water dynamics of tropical forests caused by their increasing abundance. We hypothesized that lianas would exhibit large time lags due to their extremely long stems, wide vessels and large volume of parenchyma in the stem. We examined time lags in sap flow, diel changes of stem volumetric water content (VWC) and biophysical properties of sapwood of 19 lianas and 26 co-occurring trees from 27 species in 4 forests (karst, tropical seasonal, flood plain and savanna) during a wet season. The plants varied in height/length from <5 to >60 m. The results showed that lianas had significantly higher saturated water content (SWC) and much lower wood density than trees. Seven of 19 liana individuals had no time lags; in contrast, only 3 of 26 tree individuals had no time lags. In general, lianas had shorter time lags than trees in our data set, but this difference was not significant for our most conservative analyses. Across trees and lianas, time lag duration increased with diurnal maximum changeable VWC but was independent of the body size, path length, wood density and SWC. The results suggest that in most lianas, internal stem water storage contributes little to daily water budget, while trees may rely more on stored water in the stem. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. 77 FR 75259 - Joint Report: Differences in Accounting and Capital Standards Among the Federal Banking Agencies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... consistent with U.S. generally accepted accounting principles. There were no significant differences in...] FEDERAL RESERVE SYSTEM FEDERAL DEPOSIT INSURANCE CORPORATION Joint Report: Differences in Accounting and... submit an annual report to the Committee on Financial Services of the U.S. House of Representatives and...

  14. A Commentary on "Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum"

    ERIC Educational Resources Information Center

    Kamp-Roelands, Nancy

    2013-01-01

    In this commentary, Kamp-Roelands states that it was very encouraging to observe that the Association of Chartered Certified Accountants (ACCA) recognises that responding to "Integrated Reporting" initiatives requires an "integrated approach" to accounting education. That change in financial reporting standards put pressure on…

  15. X-linked Acrogigantism (X-LAG) Syndrome: Clinical Profile and Therapeutic Responses

    PubMed Central

    Beckers, Albert; Lodish, Maya Beth; Trivellin, Giampaolo; Rostomyan, Liliya; Lee, Misu; Faucz, Fabio R; Yuan, Bo; Choong, Catherine S; Caberg, Jean-Hubert; Verrua, Elisa; Naves, Luciana Ansaneli; Cheetham, Tim D; Young, Jacques; Lysy, Philippe A; Petrossians, Patrick; Cotterill, Andrew; Shah, Nalini Samir; Metzger, Daniel; Castermans, Emilie; Ambrosio, Maria Rosaria; Villa, Chiara; Strebkova, Natalia; Mazerkina, Nadia; Gaillard, Stéphan; Barra, Gustavo Barcelos; Casulari, Luis Augusto; Neggers, Sebastian J.; Salvatori, Roberto; Jaffrain-Rea, Marie-Lise; Zacharin, Margaret; Santamaria, Beatriz Lecumberri; Zacharieva, Sabina; Lim, Ee Mun; Mantovani, Giovanna; Zatelli, Maria Chaira; Collins, Michael T; Bonneville, Jean-François; Quezado, Martha; Chittiboina, Prashant; Oldfield, Edward H.; Bours, Vincent; Liu, Pengfei; De Herder, Wouter; Pellegata, Natalia; Lupski, James R.; Daly, Adrian F.; Stratakis, Constantine A.

    2015-01-01

    X-linked acro-gigantism (X-LAG) is a new syndrome of pituitary gigantism, caused by microduplications on chromosome Xq26.3, encompassing the gene GPR101, which is highly upregulated in pituitary tumors. We conducted this study to explore the clinical, radiological and hormonal phenotype and responses to therapy in patients with X-LAG syndrome. The study included 18 patients (13 sporadic) with X-LAG and a microduplication in chromosome Xq26.3. All sporadic cases had unique duplications and the inheritance pattern in 2 families was dominant with all Xq26.3 duplication carriers being affected. Patients began to grow rapidly as early as 2–3 months of age (median 12 months). At diagnosis (median delay 27 months), patients had a median height and weight SDS score of >+3.9 SDS. Apart from the increased overall body size, the children had acromegalic symptoms including acral enlargement and facial coarsening. More than a third of cases had increased appetite. Patients had marked hypersecretion of GH/IGF-1 and prolactin, usually due to a pituitary macroadenoma or hyperplasia. Primary neurosurgical control was achieved with extensive anterior pituitary resection but postoperative hypopituitarism was frequent. Control with somatostatin analogs was not readily achieved despite moderate to high somatostatin receptor subtype-2 expression in tumor tissue. Postoperative adjuvant pegvisomant achieved control of IGF-1 all 5 cases in which it was employed. X-LAG is a new infant-onset gigantism syndrome that has a severe clinical phenotype leading to challenging disease management. PMID:25712922

  16. X-ray short-time lags in the Fe-K energy band produced by scattering clouds in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Mizumoto, Misaki; Done, Chris; Hagino, Kouichi; Ebisawa, Ken; Tsujimoto, Masahiro; Odaka, Hirokazu

    2018-07-01

    X-rays illuminating the accretion disc in active galactic nuclei give rise to an iron K line and its associated reflection spectrum that are lagged behind the continuum variability by the light-travel time from the source to the disc. The measured lag time-scales in the iron band can be as short as ˜Rg/c, where Rg is the gravitational radius, which is often interpreted as evidence for a very small continuum source close to the event horizon of a rapidly spinning black hole. However, the short lags can also be produced by reflection from more distant material, because the primary photons with no time-delay dilute the time-lags caused by the reprocessed photons. We perform a Monte Carlo simulation to calculate the dilution effect in the X-ray reverberation lags from a half-shell of neutral material placed at 100 Rg from the central source. This gives lags of ˜2 Rg/c, but the iron line is a distinctly narrow feature in the lag-energy plot, whereas the data often show a broader line. We show that both the short lag and the line broadening can be reproduced, if the scattering material is outflowing at ˜0.1c. The velocity structure in the wind can also give shifts in the line profile in the lag-energy plot calculated at different frequencies. Hence we propose that the observed broad iron reverberation lags and shifts in profile as a function of frequency of variability can arise from a disc wind at fairly large distances from the X-ray source.

  17. X-ray short-time lags in the Fe-K energy band produced by scattering clouds in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Mizumoto, Misaki; Done, Chris; Hagino, Kouichi; Ebisawa, Ken; Tsujimoto, Masahiro; Odaka, Hirokazu

    2018-05-01

    X-rays illuminating the accretion disc in active galactic nuclei give rise to an iron K line and its associated reflection spectrum which are lagged behind the continuum variability by the light-travel time from the source to the disc. The measured lag timescales in the iron band can be as short as ˜Rg/c, where Rg is the gravitational radius, which is often interpreted as evidence for a very small continuum source close to the event horizon of a rapidly spinning black hole. However, the short lags can also be produced by reflection from more distant material, because the primary photons with no time-delay dilute the time-lags caused by the reprocessed photons. We perform a Monte-Carlo simulation to calculate the dilution effect in the X-ray reverberation lags from a half-shell of neutral material placed at 100 Rg from the central source. This gives lags of ˜2 Rg/c, but the iron line is a distinctly narrow feature in the lag-energy plot, whereas the data often show a broader line. We show that both the short lag and the line broadening can be reproduced if the scattering material is outflowing at ˜0.1c. The velocity structure in the wind can also give shifts in the line profile in the lag-energy plot calculated at different frequencies. Hence we propose that the observed broad iron reverberation lags and shifts in profile as a function of frequency of variability can arise from a disc wind at fairly large distances from the X-ray source.

  18. Tyrosinase autoactivation and the problem of the lag period.

    PubMed

    Naish-Byfield, S; Riley, P A

    1998-06-01

    Evidence is presented for the binding of the quinone oxidation product of the monohydric phenol substrate, 4-hydroxyanisole, to mushroom tyrosinase. Column chromatography and SDS-PAGE separation showed labelling of the enzyme when incubated with 14C ring-labelled 4-hydroxyanisole. It is proposed that covalent binding to the enzyme and other proteins is through reaction of accessible nucleophilic groups, including thiols and amino groups, with the anisylquinone. This reductive addition enables the indirect generation of the catecholic substrate, which acts as an electron donor for the bicupric active site of met-tyrosinase and explains the lag kinetics of tyrosinase oxidation of non-cyclizing substrates. The effects of diluting the enzyme or the addition of amino acids on the lag period was consistent with a mechanism involving indirect generation of the dihydric phenol, which acts as the met-enzyme-recruiting substrate.

  19. The prescription pickup lag, an automatic prescription refill program, and community pharmacy operations.

    PubMed

    Lester, Corey A; Chui, Michelle A

    2016-01-01

    To determine the effect of an automatic prescription refill program on the prescription pickup lag in community pharmacy. A post-only quasi-experimental design comparing automatic and manual refill prescription cohorts for each of the 3 Centers for Medicare and Medicaid medication adherence metrics. A 29-store community pharmacy chain in the Midwest. Community-dwelling patients over the age of 65 years receiving prescription medications included in the statin, renin-angiotensin-aldosterone system antagonist, or non-insulin diabetes adherence metrics. An automatic prescription refill program that initiated prescription refills on a standardized, recurrent basis, eliminating the need for patients to phone in or drop off prescription refills. The prescription pickup lag, defined as the number of days between a prescription being adjudicated in the pharmacy and the prescription being picked up by the patient. A total of 37,207 prescription fills were examined. There were 20.5%, 22.4%, and 23.3% of patients enrolled in the automatic prescription refill program for the statin, renin-angiotensin-aldosterone system antagonist, and diabetes adherence metrics, respectively. Prescriptions in the automatic prescription refill cohorts experienced a median pickup lag of 7 days compared with 1 day for the manual refill prescriptions. 35.2% of all manual refill prescriptions had a pickup lag of 0 days compared with 13% for automatic refills. However, 15.4% of automatic prescription refills had a pickup lag of greater than 14 days, compared with 4.8% of manual refills. Prescriptions in the automatic prescription refill programs were associated with a significantly longer amount of time in the pharmacy before being picked up by the patient. This increased pickup lag may contribute positively by smoothing out workload demands of pharmacy staff, but may contribute negatively owing to an increased amount of rework and greater inventory requirements. Copyright © 2016 American

  20. ARE THE kHz QPO LAGS IN NEUTRON STAR 4U 1608–52 DUE TO REVERBERATION?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cackett, Edward M., E-mail: ecackett@wayne.edu

    2016-08-01

    X-ray reverberation lags have recently been discovered in both active galactic nuclei (AGNs) and black hole X-ray binaries. A recent study of the neutron star low-mass X-ray binary (LMXB) 4U 1608 52 has also shown significant lags, whose properties hint at a reverberation origin. Here, we adapt general relativistic ray tracing impulse response functions used to model X-ray reverberation in AGNs for neutron star LMXBs. Assuming that relativistic reflection forms the broad iron line and associated reflection continuum, we use reflection fits to the energy spectrum along with the impulse response functions to calculate the expected lags as a functionmore » of energy over the range of observed kHz quasi-periodic oscillation (QPO) frequencies in 4U 1608 52. We find that the lag energy spectrum is expected to increase with increasing energy above 8 keV, while the observed lags in 4U 1608 52 show the opposite behavior. This demonstrates that the lags in the lower kHz QPO of 4U 1608 52 are not solely due to reverberation. We do note, however, that the models appear to be more consistent with the much flatter lag energy spectrum observed in the upper kHz QPO of several neutron star LMXBs, suggesting that lower and upper kHz QPOs may have different origins.« less

  1. A Lagging Model for Describing Drawdown Induced by a Constant-Rate Pumping in a Leaky Confined Aquifer

    NASA Astrophysics Data System (ADS)

    Lin, Ye-Chen; Yeh, Hund-Der

    2017-10-01

    This study proposes a generalized Darcy's law with considering phase lags in both the water flux and drawdown gradient to develop a lagging flow model for describing drawdown induced by constant-rate pumping (CRP) in a leaky confined aquifer. The present model has a mathematical formulation similar to the dual-porosity model. The Laplace-domain solution of the model with the effect of wellbore storage is derived by the Laplace transform method. The time-domain solution for the case of neglecting the wellbore storage and well radius is developed by the use of Laplace transform and Weber transform. The results of sensitivity analysis based on the solution indicate that the drawdown is very sensitive to the change in each of the transmissivity and storativity. Also, a study for the lagging effect on the drawdown indicates that its influence is significant associated with the lag times. The present solution is also employed to analyze a data set taken from a CRP test conducted in a fractured aquifer in South Dakota, USA. The results show the prediction of this new solution with considering the phase lags has very good fit to the field data, especially at early pumping time. In addition, the phase lags seem to have a scale effect as indicated in the results. In other words, the lagging behavior is positively correlated with the observed distance in the Madison aquifer.

  2. Chimera and modulated drift states in a ring of nonlocally coupled oscillators with heterogeneous phase lags

    NASA Astrophysics Data System (ADS)

    Choe, Chol-Ung; Kim, Ryong-Son; Ri, Ji-Song

    2017-09-01

    We consider a ring of phase oscillators with nonlocal coupling strength and heterogeneous phase lags. We analyze the effects of heterogeneity in the phase lags on the existence and stability of a variety of steady states. A nonlocal coupling with heterogeneous phase lags that allows the system to be solved analytically is suggested and the stability of solutions along the Ott-Antonsen invariant manifold is explored. We present a complete bifurcation diagram for stationary patterns including the uniform drift and modulated drift states as well as chimera state, which reveals that the stable modulated drift state and a continuum of metastable drift states could occur due to the heterogeneity of the phase lags. We verify our theoretical results using the direct numerical simulations of the model system.

  3. Effects of Print Publication Lag in Dual Format Journals on Scientometric Indicators

    PubMed Central

    Heneberg, Petr

    2013-01-01

    Background Publication lag between manuscript submission and its final publication is considered as an important factor affecting the decision to submit, the timeliness of presented data, and the scientometric measures of the particular journal. Dual-format peer-reviewed journals (publishing both print and online editions of their content) adopted a broadly accepted strategy to shorten the publication lag: to publish the accepted manuscripts online ahead of their print editions, which may follow days, but also years later. Effects of this widespread habit on the immediacy index (average number of times an article is cited in the year it is published) calculation were never analyzed. Methodology/Principal Findings Scopus database (which contains nearly up-to-date documents in press, but does not reveal citations by these documents until they are finalized) was searched for the journals with the highest total counts of articles in press, or highest counts of articles in press appearing online in 2010–2011. Number of citations received by the articles in press available online was found to be nearly equal to citations received within the year when the document was assigned to a journal issue. Thus, online publication of in press articles affects severely the calculation of immediacy index of their source titles, and disadvantages online-only and print-only journals when evaluating them according to the immediacy index and probably also according to the impact factor and similar measures. Conclusions/Significance Caution should be taken when evaluating dual-format journals supporting long publication lag. Further research should answer the question, on whether the immediacy index should be replaced by an indicator based on the date of first publication (online or in print, whichever comes first) to eliminate the problems analyzed in this report. Information value of immediacy index is further questioned by very high ratio of authors’ self-citations among the

  4. Investigating effects of hydroxypropyl methylcellulose (HPMC) molecular weight grades on lag time of press-coated ethylcellulose tablets.

    PubMed

    Patadia, Riddhish; Vora, Chintan; Mittal, Karan; Mashru, Rajashree

    2016-11-01

    The research undertaken exemplifies the effects of hydroxypropyl methylcellulose (HPMC) molecular weight (MW) grades of on lag time of press-coated ethylcellulose (EC) tablets. The formulation comprised an immediate release core (containing prednisone as a model drug) surrounded by compression coating with variegated EC-HPMC blends. Five selected HPMC grades (E5, E15, E50, K100LV and K4M) were explored at three different concentrations (10% w/w, 20% w/w and 30% w/w in outer coat) to understand their effects on lag time and drug release. In vitro drug release testing demonstrated that, with increase in concentration of E5 and E15, up to 30% w/w, the mean lag time decreased progressively; whereas with remaining grades, the mean lag time initially decreased up to 20% w/w level and thereafter increased for 30% w/w level. Importantly, with increase in HPMC concentration in the outer coat, the variability in lag time (%RSD; n = 6) was decreased for each of E5, E15 and E50, whereas increased for K100LV and K4M. In general, the variability in lag time was increased with increase in HPMC MW at studied concentration levels. Markedly, tablets with 30% w/w K4M in outer coat exhibited slight premature release (before the rupture of outer coat) along with high variability in lag time. Overall, the study concluded that low MW HPMCs (E5, E15 and E50) were found rather efficient than higher MW HPMCs for developing robust EC-based press-coated pulsatile release formulations where precise lag time followed by sharp burst release is desired.

  5. A lagged variable model for characterizing temporally dynamic export of legacy anthropogenic nitrogen from watersheds to rivers.

    PubMed

    Chen, Dingjiang; Guo, Yi; Hu, Minpeng; Dahlgren, Randy A

    2015-08-01

    Legacy nitrogen (N) sources originating from anthropogenic N inputs (NANI) may be a major cause of increasing riverine N exports in many regions, despite a significant decline in NANI. However, little quantitative knowledge exists concerning the lag effect of NANI on riverine N export. As a result, the N leaching lag effect is not well represented in most current watershed models. This study developed a lagged variable model (LVM) to address temporally dynamic export of watershed NANI to rivers. Employing a Koyck transformation approach used in economic analyses, the LVM expresses the indefinite number of lag terms from previous years' NANI with a lag term that incorporates the previous year's riverine N flux, enabling us to inversely calibrate model parameters from measurable variables using Bayesian statistics. Applying the LVM to the upper Jiaojiang watershed in eastern China for 1980-2010 indicated that ~97% of riverine export of annual NANI occurred in the current year and succeeding 10 years (~11 years lag time) and ~72% of annual riverine N flux was derived from previous years' NANI. Existing NANI over the 1993-2010 period would have required a 22% reduction to attain the target TN level (1.0 mg N L(-1)), guiding watershed N source controls considering the lag effect. The LVM was developed with parsimony of model structure and parameters (only four parameters in this study); thus, it is easy to develop and apply in other watersheds. The LVM provides a simple and effective tool for quantifying the lag effect of anthropogenic N input on riverine export in support of efficient development and evaluation of watershed N control strategies.

  6. An experimental and analytical investigation of stall effects on flap-lag stability in forward flight

    NASA Technical Reports Server (NTRS)

    Nagabhushanam, J.; Gaonkar, Gopal H.; Mcnulty, Michael J.

    1987-01-01

    Experiments have been performed with a 1.62 m diameter hingeless rotor in a wind tunnel to investigate flap-lag stability of isolated rotors in forward flight. The three-bladed rotor model closely approaches the simple theoretical concept of a hingeless rotor as a set of rigid, articulated flap-lag blades with offset and spring restrained flap and lag hinges. Lag regressing mode stability data was obtained for advance ratios as high as 0.55 for various combinations of collective pitch and shaft angle. The prediction includes quasi-steady stall effects on rotor trim and Floquet stability analyses. Correlation between data and prediction is presented and is compared with that of an earlier study based on a linear theory without stall effects. While the results with stall effects show marked differences from the linear theory results, the stall theory still falls short of adequate agreement with the experimental data.

  7. Expression of LAG-3 defines exhaustion of intratumoral PD-1+ T cells and correlates with poor outcome in follicular lymphoma

    PubMed Central

    Yang, Zhi-Zhang; Kim, Hyo Jin; Villasboas, Jose C.; Chen, Ya-Ping; Price-Troska, Tammy; Jalali, Shahrzad; Wilson, Mara; Novak, Anne J.; Ansell, Stephen M.

    2017-01-01

    Exhausted T-cells in follicular lymphoma (FL) typically express PD-1, but expression of PD-1 is not limited to exhausted cells. Although expected to be functionally suppressed, we found that the population of intratumoral PD-1+ T cells were predominantly responsible for production of cytokines and granules. This surprising finding prompted us to explore the involvement of LAG-3 to specifically identify functionally exhausted T cells. We found that LAG-3 was expressed on a subset of intratumoral T cells from FL and LAG-3+ T cells almost exclusively came from PD-1+ population. CyTOF analysis revealed that intratumoral LAG-3+ T cells were phenotypically heterogeneous as LAG-3 was expressed on a variety of T cell subsets. In contrast to PD-1+LAG-3- cells, intratumoral PD-1+LAG-3+ T cells exhibited reduced capacity to produce cytokines and granules. LAG-3 expression could be substantially upregulated on CD4+ or CD8+ T cells by IL-12, a cytokine that has been shown to induce T-cell exhaustion and be increased in the serum of lymphoma patients. Furthermore, we found that blockade of both PD-1 and LAG-3 signaling enhanced the function of intratumoral CD8+ T cells resulting in increased IFN-γ and IL-2 production. Clinically, LAG-3 expression on intratumoral T cells correlated with a poor outcome in FL patients. Taken together, we find that LAG-3 expression is necessary to identify the population of intratumoral PD-1+ T cells that are functionally exhausted and, in contrast, find that PD-1+LAG-3- T cells are simply activated cells that are immunologically functional. These findings may have important implications for immune checkpoint therapy in FL. PMID:28977875

  8. Review: the environmental status and implications of the nitrate time lag in Europe and North America

    NASA Astrophysics Data System (ADS)

    Vero, Sara E.; Basu, Nandita B.; Van Meter, Kimberly; Richards, Karl G.; Mellander, Per-Erik; Healy, Mark G.; Fenton, Owen

    2018-02-01

    The efficacy of water quality policies aiming to reduce or prevent nitrate contamination of waterbodies may be constrained by the inherent delay or "time lag" of water and solute transport through unsaturated (soil) and saturated (groundwater) pathways. These delays must be quantified in order to establish realistic deadlines, thresholds and policy expectations, and to design effective best management practices. The objective of this review is to synthesise the current state of research on nitrate-related time lags in both the European and North American environmental and legislative contexts. The durations of time lags have been found to differ according to climatic, pedological, landscape and management scenarios. Elucidation of these driving factors at a watershed scale is essential where water quality is impaired or at risk. Finally, the existence of time lags is increasingly being acknowledged at a policy level and incorporated into the development of environmental legislation. However, the full impact of these time lags is not yet fully understood or appreciated, and continued outreach and education in scientific, public and policy venues is still required.

  9. 78 FR 46177 - Third-Party Provision of Ancillary Services; Accounting and Financial Reporting for New Electric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ...The Federal Energy Regulatory Commission (Commission) is revising its regulations to foster competition and transparency in ancillary services markets. The Commission is revising certain aspects of its current market-based rate regulations, ancillary services requirements under the pro forma open-access transmission tariff (OATT), and accounting and reporting requirements. Specifically, the Commission is revising its regulations to reflect reforms to its Avista policy governing the sale of ancillary services at market-based rates to public utility transmission providers. The Commission is also requiring each public utility transmission provider to add to its OATT Schedule 3 a statement that it will take into account the speed and accuracy of regulation resources in its determination of reserve requirements for Regulation and Frequency Response service, including as it reviews whether a self-supplying customer has made ``alternative comparable arrangements'' as required by the Schedule. The final rule also requires each public utility transmission provider to post certain Area Control Error data as described in the final rule. Finally, the Commission is revising the accounting and reporting requirements under its Uniform System of Accounts for public utilities and licensees and its forms, statements, and reports, contained in FERC Form No. 1, Annual Report of Major Electric Utilities, Licensees and Others, FERC Form No. 1-F, Annual Report for Nonmajor Public Utilities and Licensees, and FERC Form No. 3-Q, Quarterly Financial Report of Electric Utilities, Licensees, and Natural Gas Companies, to better account for and report transactions associated with the use of energy storage devices in public utility operations.

  10. Detecting PM2.5's Correlations between Neighboring Cities Using a Time-Lagged Cross-Correlation Coefficient.

    PubMed

    Wang, Fang; Wang, Lin; Chen, Yuming

    2017-08-31

    In order to investigate the time-dependent cross-correlations of fine particulate (PM2.5) series among neighboring cities in Northern China, in this paper, we propose a new cross-correlation coefficient, the time-lagged q-L dependent height crosscorrelation coefficient (denoted by p q (τ, L)), which incorporates the time-lag factor and the fluctuation amplitude information into the analogous height cross-correlation analysis coefficient. Numerical tests are performed to illustrate that the newly proposed coefficient ρ q (τ, L) can be used to detect cross-correlations between two series with time lags and to identify different range of fluctuations at which two series possess cross-correlations. Applying the new coefficient to analyze the time-dependent cross-correlations of PM2.5 series between Beijing and the three neighboring cities of Tianjin, Zhangjiakou, and Baoding, we find that time lags between the PM2.5 series with larger fluctuations are longer than those between PM2.5 series withsmaller fluctuations. Our analysis also shows that cross-correlations between the PM2.5 series of two neighboring cities are significant and the time lags between two PM2.5 series of neighboring cities are significantly non-zero. These findings providenew scientific support on the view that air pollution in neighboring cities can affect one another not simultaneously but with a time lag.

  11. The Medicare Cost Report and the limits of hospital accountability: improving financial accounting data.

    PubMed

    Kane, N M; Magnus, S A

    2001-02-01

    Health policy makers, legislators, providers, payers, and a broad range of other players in the health care market routinely seek information on hospital financial performance. Yet the data at their disposal are limited, especially since hospitals' audited financial statements--the "gold standard" in hospital financial reporting--are not publicly available in many states. As a result, the Medicare Cost Report (MCR), filed annually by most U.S. hospitals in order to receive payment for treating Medicare patients, has become the primary public source of hospital financial information. However, financial accounting elements in the MCR are unreliable, poorly defined, and lacking in critical detail. Comparative analyses of MCRs and matched, audited financial statements reveal long-standing problems with the MCR's data, including major differences in reported profits; variations in the reporting of both revenues and expenses; an absence of relevant details, such as charity care, bad debt, operating versus nonoperating income, and affiliate transactions; an inconsistent classification of changes in net assets; and a failure to provide cash flow statements. Because of these problems, MCR financial data give only a limited and often inaccurate picture of the financial position of hospitals. Audited financial statements provide a more complete perspective, enabling analysts to address important questions left unanswered by the MCR data. Regulatory action is needed to create a national database of financial information based upon audited statements.

  12. 75 FR 54802 - Account Ownership and Control Report; Notice of Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    .... MATTERS TO BE CONSIDERED: Agenda: (1) Sources of Ownership and Control Report Data; and (2) Implementation..., control and related information for all trading accounts active on U.S. futures exchanges and other...

  13. National Aeronautics and Space Administration Fiscal Year 2001 Accountability Report

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The National Aeronautics and Space Administration (NASA) is an independent Agency established to plan and manage the future of the Nation's civil aeronautics and space program. This Accountability Report covers Federal Fiscal Year (FY) 2001 (October 1, 2000, through September 30, 2001), with discussion of some subsequent events. The Report contains an overview addressing the Agency's critical programs and financial performance and includes highlights of performance organized by goals and objectives of the Enterprises and Crosscutting Processes. The Report also summarizes NASA's stewardship over budget and financial resources, including audited financial statements and footnotes. The financial statements reflect an overall position of offices and activities, including assets and liabilities, as well as results of operations, pursuant to requirements of Federal law (31 U.S.C. 3515(b)). The auditor's opinions on NASA's financial statements, reports on internal controls, and compliance with laws and regulations are included in this report.

  14. Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets.

    PubMed

    Patadia, Riddhish; Vora, Chintan; Mittal, Karan; Mashru, Rajashree

    2016-01-01

    The research envisaged focuses on vital impacts of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose (EC) tablets using prednisone as a model drug. Several lubricants and glidants such as magnesium stearate, colloidal SiO2, sodium stearyl fumarate, talc, stearic acid, polyethylene glycol (6000) and glyceryl behenate were investigated to understand their effects on lag time by changing their concentrations in outer coat. Further, the effects of hydrophilic additives on lag time were examined for hydroxypropylmethylcellulose (E5), hydroxypropylcellulose (EF and SSL), povidone (K30), copovidone, polyethylene glycol (4000), lactose and mannitol. In vitro drug release testing revealed that each selected lubricant/glidant, if present even at concentration of 0.25% w/w, significantly reduced the lag time of press coated tablets. Specifically, colloidal SiO2 and/or magnesium stearate were detrimental while other lubricants/glidants were relatively less injurious. Among hydrophilic additives, freely water soluble fillers had utmost influence in lag time, whereas, comparatively less impact was observed with polymeric binders. Concisely, glidant and lubricant should be chosen to have minimal impact on lag time and further judicious selection of hydrophilic additives should be exercised for modulating lag time of pulsatile release formulations.

  15. Reducing the lag of accommodation by auditory biofeedback: A pilot study.

    PubMed

    Wagner, Sandra; Ohlendorf, Arne; Schaeffel, Frank; Wahl, Siegfried

    2016-12-01

    The purpose of this study was to investigate whether a reduction of the accommodative lag is possible by training the accuracy of accommodation using auditory biofeedback. Accommodation responses were measured in thirty-one young adults with myopia for dioptric target distances of 2.0, 2.5, and 3.0D using an eccentric infrared photorefractor. For the biofeedback training, subjects were randomly assigned to an experimental (n=15) or a control group (n=16). Subjects of the experimental group were provided with two tones while fixating a target, one tone was related to their accommodative response and the second to the target distance. Their task was to match these tones. The control group did not receive any auditory biofeedback. Two different training methods were applied, a continuous training of 200s, and ten consecutive sessions of 20s each. The training effects on the lag of accommodation (change Δ) were highly variable. Regarding the entire study group, the observed change in the accommodative lag was greater at closer distances, while no difference between the two training methods was revealed. Nevertheless, seven experimental subjects reduced their lag by ⩾0.3D (3.0D target distance: Δ long =-0.29±0.20D, Δ short =-0.24±0.21D). This reduction was also seen in two control subjects. Remeasurement revealed that the average training effect cannot be preserved over a period of 5-7days. The current investigation has shown that the accuracy of accommodation can be trained in some subjects using auditory biofeedback for target distances of 2.5D or closer. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. A Fixed-Lag Kalman Smoother to Filter Power Line Interference in Electrocardiogram Recordings.

    PubMed

    Warmerdam, G J J; Vullings, R; Schmitt, L; Van Laar, J O E H; Bergmans, J W M

    2017-08-01

    Filtering power line interference (PLI) from electrocardiogram (ECG) recordings can lead to significant distortions of the ECG and mask clinically relevant features in ECG waveform morphology. The objective of this study is to filter PLI from ECG recordings with minimal distortion of the ECG waveform. In this paper, we propose a fixed-lag Kalman smoother with adaptive noise estimation. The performance of this Kalman smoother in filtering PLI is compared to that of a fixed-bandwidth notch filter and several adaptive PLI filters that have been proposed in the literature. To evaluate the performance, we corrupted clean neonatal ECG recordings with various simulated PLI. Furthermore, examples are shown of filtering real PLI from an adult and a fetal ECG recording. The fixed-lag Kalman smoother outperforms other PLI filters in terms of step response settling time (improvements that range from 0.1 to 1 s) and signal-to-noise ratio (improvements that range from 17 to 23 dB). Our fixed-lag Kalman smoother can be used for semi real-time applications with a limited delay of 0.4 s. The fixed-lag Kalman smoother presented in this study outperforms other methods for filtering PLI and leads to minimal distortion of the ECG waveform.

  17. Lagged effects of family-supportive organization perceptions and supervision in relation to generalized work-related resources.

    PubMed

    Matthews, Russell A; Toumbeva, Tatiana H

    2015-07-01

    In the present study, grounded in organizational support and social exchange theory, the dynamic lagged interplay between family supportive supervision (FSS), family supportive organization perceptions (FSOP), perceived organizational support (POS), and leader-member exchange (LMX) was examined. Data were collected from 435 respondents over 3 time points with 6-week lags between assessments. Consistent with theory, FSS had a significant lagged effect on FSOP, whereas the reverse relationship was not supported. Interestingly, contrary to conservation of resources theory, we did not find significant lagged effects between POS and FSOP. Results further indicated that LMX and FSS were reciprocally related over time, suggesting the potential for a dynamic, mutually beneficial exchange relationship between subordinates and supervisors. Theoretical implications and considerations for research and practice are discussed. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  18. On the Nature of QPO Phase Lags in Black Hole Candidates

    NASA Technical Reports Server (NTRS)

    Shaposhnikov, Nikolai

    2012-01-01

    Observations of quasi-periodic oscillations (QPOs) in X-ray binaries hold a key to understanding many aspects of these enigmatic systems. Complex appearance of the Fourier phase lags related to QPOs is one of the most puzzling observational effects in accreting black holes. In this Letter we show that QPO properties, including phase lags, can be explained in a framework of a simple scenario, where the oscillating media provides a feedback on the emerging spectrum. We demonstrate that the QPO waveform is presented by the product of a perturbation and a time delayed response factors, where the response is energy dependent. The essential property of this effect is its non-linear and multiplicative nature. Our multiplicative reverberation model successfully describes the QPO components in energy dependent power spectra as well as the appearance of the phase lags between signal in different energy bands. We apply our model to QPOs observed by Rossi X-ray Timing Explorer in BH candidate XTE J1550-564. We briefly discuss the implications of the observed energy dependence of the QPO reverberation times and amplitudes to the nature of the power law spectral component and its variability.

  19. 20 CFR 726.112 - Reports required of self-insurer; examination of accounts of self-insurer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Office may inspect or examine the books of account, records, and other papers of a self-insurer for the... the Office may in its discretion accept an adequate report of a certified public accountant. (c...

  20. 20 CFR 726.112 - Reports required of self-insurer; examination of accounts of self-insurer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Office may inspect or examine the books of account, records, and other papers of a self-insurer for the... the Office may in its discretion accept an adequate report of a certified public accountant. (c...

  1. 20 CFR 726.112 - Reports required of self-insurer; examination of accounts of self-insurer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Office may inspect or examine the books of account, records, and other papers of a self-insurer for the... the Office may in its discretion accept an adequate report of a certified public accountant. (c...

  2. 20 CFR 726.112 - Reports required of self-insurer; examination of accounts of self-insurer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Office may inspect or examine the books of account, records, and other papers of a self-insurer for the... the Office may in its discretion accept an adequate report of a certified public accountant. (c...

  3. 20 CFR 726.112 - Reports required of self-insurer; examination of accounts of self-insurer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Office may inspect or examine the books of account, records, and other papers of a self-insurer for the... the Office may in its discretion accept an adequate report of a certified public accountant. (c...

  4. Extending the Distributed Lag Model framework to handle chemical mixtures.

    PubMed

    Bello, Ghalib A; Arora, Manish; Austin, Christine; Horton, Megan K; Wright, Robert O; Gennings, Chris

    2017-07-01

    Distributed Lag Models (DLMs) are used in environmental health studies to analyze the time-delayed effect of an exposure on an outcome of interest. Given the increasing need for analytical tools for evaluation of the effects of exposure to multi-pollutant mixtures, this study attempts to extend the classical DLM framework to accommodate and evaluate multiple longitudinally observed exposures. We introduce 2 techniques for quantifying the time-varying mixture effect of multiple exposures on an outcome of interest. Lagged WQS, the first technique, is based on Weighted Quantile Sum (WQS) regression, a penalized regression method that estimates mixture effects using a weighted index. We also introduce Tree-based DLMs, a nonparametric alternative for assessment of lagged mixture effects. This technique is based on the Random Forest (RF) algorithm, a nonparametric, tree-based estimation technique that has shown excellent performance in a wide variety of domains. In a simulation study, we tested the feasibility of these techniques and evaluated their performance in comparison to standard methodology. Both methods exhibited relatively robust performance, accurately capturing pre-defined non-linear functional relationships in different simulation settings. Further, we applied these techniques to data on perinatal exposure to environmental metal toxicants, with the goal of evaluating the effects of exposure on neurodevelopment. Our methods identified critical neurodevelopmental windows showing significant sensitivity to metal mixtures. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Modeling the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity values.

    PubMed

    Muñoz-Cuevas, Marina; Fernández, Pablo S; George, Susan; Pin, Carmen

    2010-05-01

    The dynamic model for the growth of a bacterial population described by Baranyi and Roberts (J. Baranyi and T. A. Roberts, Int. J. Food Microbiol. 23:277-294, 1994) was applied to model the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity (a(w)) values. To model the duration of the lag phase, the dependence of the parameter h(0), which quantifies the amount of work done during the lag period, on the previous and current environmental conditions was determined experimentally. This parameter depended not only on the magnitude of the change between the previous and current environmental conditions but also on the current growth conditions. In an exponentially growing population, any change in the environment requiring a certain amount of work to adapt to the new conditions initiated a lag period that lasted until that work was finished. Observations for several scenarios in which exponential growth was halted by a sudden change in the temperature and/or a(w) were in good agreement with predictions. When a population already in a lag period was subjected to environmental fluctuations, the system was reset with a new lag phase. The work to be done during the new lag phase was estimated to be the workload due to the environmental change plus the unfinished workload from the uncompleted previous lag phase.

  6. Spatial and temporal dynamics of deep percolation, lag time and recharge in an irrigated semi-arid region

    NASA Astrophysics Data System (ADS)

    Nazarieh, F.; Ansari, H.; Ziaei, A. N.; Izady, A.; Davari, K.; Brunner, P.

    2018-05-01

    The time required for deep percolating water to reach the water table can be considerable in areas with a thick vadose zone. Sustainable groundwater management, therefore, has to consider the spatial and temporal dynamics of groundwater recharge. The key parameters that control the lag time have been widely examined in soil physics using small-scale lysimeters and modeling studies. However, only a small number of studies have analyzed how deep-percolation rates affect groundwater recharge dynamics over large spatial scales. This study examined how the parameters influencing lag time affect groundwater recharge in a semi-arid catchment under irrigation (in northeastern Iran) using a numerical modeling approach. Flow simulations were performed by the MODFLOW-NWT code with the Vadose-Zone Flow (UZF) Package. Calibration of the groundwater model was based on data from 48 observation wells. Flow simulations showed that lag times vary from 1 to more than 100 months. A sensitivity analysis demonstrated that during drought conditions, the lag time was highly sensitive to the rate of deep percolation. The study illustrated two critical points: (1) the importance of providing estimates of the lag time as a basis for sustainable groundwater management, and (2) lag time not only depends on factors such as soil hydraulic conductivity or vadose zone depth but also depends on the deep-percolation rates and the antecedent soil-moisture condition. Therefore, estimates of the lag time have to be associated with specific percolation rates, in addition to depth to groundwater and soil properties.

  7. Lag Phase Is a Distinct Growth Phase That Prepares Bacteria for Exponential Growth and Involves Transient Metal Accumulation

    PubMed Central

    Rolfe, Matthew D.; Rice, Christopher J.; Lucchini, Sacha; Pin, Carmen; Thompson, Arthur; Cameron, Andrew D. S.; Alston, Mark; Stringer, Michael F.; Betts, Roy P.; Baranyi, József; Peck, Michael W.

    2012-01-01

    Lag phase represents the earliest and most poorly understood stage of the bacterial growth cycle. We developed a reproducible experimental system and conducted functional genomic and physiological analyses of a 2-h lag phase in Salmonella enterica serovar Typhimurium. Adaptation began within 4 min of inoculation into fresh LB medium with the transient expression of genes involved in phosphate uptake. The main lag-phase transcriptional program initiated at 20 min with the upregulation of 945 genes encoding processes such as transcription, translation, iron-sulfur protein assembly, nucleotide metabolism, LPS biosynthesis, and aerobic respiration. ChIP-chip revealed that RNA polymerase was not “poised” upstream of the bacterial genes that are rapidly induced at the beginning of lag phase, suggesting a mechanism that involves de novo partitioning of RNA polymerase to transcribe 522 bacterial genes within 4 min of leaving stationary phase. We used inductively coupled plasma mass spectrometry (ICP-MS) to discover that iron, calcium, and manganese are accumulated by S. Typhimurium during lag phase, while levels of cobalt, nickel, and sodium showed distinct growth-phase-specific patterns. The high concentration of iron during lag phase was associated with transient sensitivity to oxidative stress. The study of lag phase promises to identify the physiological and regulatory processes responsible for adaptation to new environments. PMID:22139505

  8. Behavioral Engagement and Reading Achievement in Elementary-School-Age Children: A Longitudinal Cross-Lagged Analysis

    ERIC Educational Resources Information Center

    Guo, Ying; Sun, Shuyan; Breit-Smith, Allison; Morrison, Frederick J.; Connor, Carol McDonald

    2015-01-01

    Using data from the National Institute of Child Health and Human Development's Study of Early Child Care and Youth Development, this study examined the cross-lagged relations between behavioral engagement and reading achievement in elementary school and whether these cross-lagged relations differed between low-socioeconomic status (SES) and mid-…

  9. Are the U.S. territories lagging behind in diabetes care practices?

    PubMed

    Ogilvie, Rachel P; Patel, Shivani A; Narayan, K M Venkat; Mehta, Neil K

    2018-05-09

    Although U.S. territories fall within the mandate outlined by Healthy People 2020, they remain neglected in diabetes care research. We compared the prevalence and secular trends of four recommended diabetes care practices in the U.S. territories of Guam, Puerto Rico, and the U.S. Virgin Islands to the 50 United States and D.C. ("U.S. States") in 2001-2015. Data were from 390,268 adult participants with self-reported physician diagnosed diabetes in the Behavioral Risk Factor Surveillance System. Diabetes care practices included biannual HbA1c tests, attendance of diabetes education classes, daily self-monitoring of blood glucose, and receipt of annual foot examination. Practices were compared by U.S. territory and between territories and U.S. states. Multivariable models accounted for age, sex, education, and year. Of adults with diagnosed diabetes, 7% to 11% in the U.S. territories engaged in all four recommended diabetes care practices compared with 25% for those, on average, in U.S. states. Relative to the U.S. states, on average, the proportion achieving biannual HbA1c testing was lower in Guam and the U.S. Virgin Islands (45.6% and 44.9% vs. 62.2%), while annual foot examinations were lower in Puerto Rico (45.9% vs 66.1% in the U.S. states). Diabetes education and daily glucose self-monitoring were lower in all three territories. U.S. territories lag behind U.S. states in diabetes care practices. Policies aimed at improving diabetes care practices are needed in the U.S. territories to achieve Healthy People 2020 goals and attain parity with U.S. states. Copyright © 2018 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  10. Theory for Transitions Between Exponential and Stationary Phases: Universal Laws for Lag Time

    NASA Astrophysics Data System (ADS)

    Himeoka, Yusuke; Kaneko, Kunihiko

    2017-04-01

    The quantitative characterization of bacterial growth has attracted substantial attention since Monod's pioneering study. Theoretical and experimental works have uncovered several laws for describing the exponential growth phase, in which the number of cells grows exponentially. However, microorganism growth also exhibits lag, stationary, and death phases under starvation conditions, in which cell growth is highly suppressed, for which quantitative laws or theories are markedly underdeveloped. In fact, the models commonly adopted for the exponential phase that consist of autocatalytic chemical components, including ribosomes, can only show exponential growth or decay in a population; thus, phases that halt growth are not realized. Here, we propose a simple, coarse-grained cell model that includes an extra class of macromolecular components in addition to the autocatalytic active components that facilitate cellular growth. These extra components form a complex with the active components to inhibit the catalytic process. Depending on the nutrient condition, the model exhibits typical transitions among the lag, exponential, stationary, and death phases. Furthermore, the lag time needed for growth recovery after starvation follows the square root of the starvation time and is inversely related to the maximal growth rate. This is in agreement with experimental observations, in which the length of time of cell starvation is memorized in the slow accumulation of molecules. Moreover, the lag time distributed among cells is skewed with a long time tail. If the starvation time is longer, an exponential tail appears, which is also consistent with experimental data. Our theory further predicts a strong dependence of lag time on the speed of substrate depletion, which can be tested experimentally. The present model and theoretical analysis provide universal growth laws beyond the exponential phase, offering insight into how cells halt growth without entering the death phase.

  11. A penalized framework for distributed lag non-linear models.

    PubMed

    Gasparrini, Antonio; Scheipl, Fabian; Armstrong, Ben; Kenward, Michael G

    2017-09-01

    Distributed lag non-linear models (DLNMs) are a modelling tool for describing potentially non-linear and delayed dependencies. Here, we illustrate an extension of the DLNM framework through the use of penalized splines within generalized additive models (GAM). This extension offers built-in model selection procedures and the possibility of accommodating assumptions on the shape of the lag structure through specific penalties. In addition, this framework includes, as special cases, simpler models previously proposed for linear relationships (DLMs). Alternative versions of penalized DLNMs are compared with each other and with the standard unpenalized version in a simulation study. Results show that this penalized extension to the DLNM class provides greater flexibility and improved inferential properties. The framework exploits recent theoretical developments of GAMs and is implemented using efficient routines within freely available software. Real-data applications are illustrated through two reproducible examples in time series and survival analysis. © 2017 The Authors Biometrics published by Wiley Periodicals, Inc. on behalf of International Biometric Society.

  12. Modeling of photocurrent and lag signals in amorphous selenium x-ray detectors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siddiquee, Sinchita; Kabir, M. Z., E-mail: kabir@encs.concordia.ca

    2015-07-15

    A mathematical model for transient photocurrent and lag signal in x-ray imaging detectors has been developed by considering charge carrier trapping and detrapping in the energy distributed defect states under exponentially distributed carrier generation across the photoconductor. The model for the transient and steady-state carrier distributions and hence the photocurrent has been developed by solving the carrier continuity equation for both holes and electrons. The residual (commonly known as lag signal) current is modeled by solving the trapping rate equations considering the thermal release and trap filling effects. The model is applied to amorphous selenium (a-Se) detectors for both chestmore » radiography and mammography. The authors analyze the dependence of the residual current on various factors, such as x-ray exposure, applied electric field, and temperature. The electron trapping and detrapping mostly determines the residual current in a-Se detectors. The lag signal is more prominent in chest radiographic detector than in mammographic detectors. The model calculations are compared with the published experimental data and show a very good agreement.« less

  13. 14 CFR Sec. 1-3 - General description of system of accounts and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... reports. (a) This system of accounts and reports is designed to permit limited contraction or expansion to... comparability as between air carriers. In its administration three air carrier groups, designated Group I, Group II, and Group III, respectively (see section 04), are established by the BTS. This grouping will be...

  14. A Study on Financial Reporting Standards and Accounting Quality- Evidence from China

    NASA Astrophysics Data System (ADS)

    Liou, Cheng-Hwai

    2013-02-01

    According to institutional theorists, the forms and business models of corporation are mainly shaped by factors such as politics, regulations, social norms and cultures. This paper examines how the International Financial Reporting Standards (IFRS) and institutional environment influence the accounting quality, in response to the threat of political extraction in China. We took mainland China as an example instead in our study, following the accounting quality definition of Barth et al. [2], we found that the developments of Chinese government performance audit are conspicuously different by region; to reflect such differences, we elaborated our research by dividing mainland China into 31 categories (provinces or cities). We set 2003-2010 as the time horizon for this study. After testing the Regression model, our empirical research achieved two conclusions: 1) IFRS adoption in China should significantly improve the accounting quality, and 2) IFRS and institutional environment should synthetically influence the quality of accounting as well.

  15. A Time Lag Analysis of Temporal Relations between Motivation, Academic Achievement, and Two Cognitive Abilities

    ERIC Educational Resources Information Center

    Greene, Monica R.; Pasnak, Robert; Romero, Sandy L.

    2009-01-01

    Research Findings: The present study employed a time lag design to assess temporal relationships between motivation, academic achievement, and cognitive development. Eighty-one children from 2 preschool programs were measured twice, with an 11-week time lag, on 2 measures of motivation (marble drop task, bean bag toss task), 2 measures of…

  16. Time-lagged intraspecific competition in temporally separated cohorts of a generalist insect.

    PubMed

    Barnes, Elizabeth E; Murphy, Shannon M

    2018-03-01

    Competition can have far-reaching consequences for insect fitness and dispersion. Time-lagged interspecific competition is known to negatively affect fitness, yet time-lagged intraspecific competition is rarely studied outside of outbreak conditions. We tested the impact of competition between larval cohorts of the western tent caterpillar (Malacosoma californicum) feeding on chokecherry (Prunus virginiana). We reared larvae on host plants that either had or did not have feeding damage from tent caterpillars the previous season to test the bottom-up fitness effects of intraspecific competition. We measured host-plant quality to test potential mechanisms for bottom-up effects and conducted field oviposition surveys to determine if female adult tent caterpillars avoided host plants with evidence of prior tent caterpillar presence. We found that time-lagged intraspecific competition impacted tent caterpillar fitness by reducing female pupal mass, which is a predictor of lifetime fitness. We found that plants that had been fed upon by tent caterpillars the previous season had leaves that were significantly tougher than plants that had not been fed upon by tent caterpillars, which may explain why female tent caterpillars suffered reduced fitness on these plants. Finally, we found that there were fewer tent caterpillar egg masses on plants that had tent caterpillars earlier in the season than plants without tent caterpillars, which suggests that adult females avoid these plants for oviposition. Our results confirm that intraspecific competition occurs among tent caterpillars and suggests that time-lagged intraspecific competition has been overlooked as an important component of insect fitness.

  17. Inclination dependence of QPO phase lags in black hole X-ray binaries

    NASA Astrophysics Data System (ADS)

    van den Eijnden, J.; Ingram, A.; Uttley, P.; Motta, S. E.; Belloni, T. M.; Gardenier, D. W.

    2017-01-01

    Quasi-periodic oscillations (QPOs) with frequencies from ˜0.05to30 Hz are a common feature in the X-ray emission of accreting black hole binaries. As the QPOs originate from the innermost accretion flow, they provide the opportunity to probe the behaviour of matter in extreme gravity. In this paper, we present a systematic analysis of the inclination dependence of phase lags associated with both type-B and type-C QPOs in a sample of 15 Galactic black hole binaries. We find that the phase lag at the type-C QPO frequency strongly depends on inclination, both in evolution with the QPO frequency and sign. Although we find that the type-B QPO soft lags are associated with high-inclination sources, the source sample is too small to confirm that this as a significant inclination dependence. These results are consistent with a geometrical origin of type-C QPOs and a different origin for type-B and type-C QPOs. We discuss the possibility that the phase lags originate from a pivoting spectral power law during each QPO cycle, while the inclination dependence arises from differences in dominant relativistic effects. We also search for energy dependences in the type-C QPO frequency. We confirm this effect in the three known sources (GRS 1915+105, H1743-322 and XTE J1550-564) and newly detect it in XTE J1859+226. Lastly, our results indicate that the unknown inclination sources XTE J1859+226 and MAXI J1543-564 are most consistent with a high inclination.

  18. Task Force on Education Funding Equity, Accountability, and Partnerships. Final Report.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Legislative Services, Annapolis.

    In 1997, Maryland formed the Task Force on Education Funding Equity, Accountability, and Partnerships. The group made a comprehensive review of education funding and programs in grades K-12 to ensure that students throughout Maryland have an equal opportunity for academic success. The task force's final report features the membership roster, the…

  19. Responses to positive affect, life satisfaction and self-esteem: A cross-lagged panel analysis during middle adolescence.

    PubMed

    Gomez-Baya, Diego; Mendoza, Ramon; Gaspar, Tania; Gomes, Paulo

    2018-05-11

    During middle adolescence, elevated stress and a greater presence of psychological disorders have been documented. The research has paid little attention to the regulation of positive affective states. Fredrickson's broaden-and-build theory suggests that cultivating positive emotions helps to build resources that boost well-being. The current research aimed to examine the longitudinal associations between responses to positive affect (emotion-focused positive rumination, self-focused positive rumination, and dampening) and psychological adjustment (self-esteem and life satisfaction) during middle adolescence. A longitudinal study with two waves separated by one year was conducted, assessing 977 adolescents (M = 13.81, SD = 0.79; 51.5% boys) with self-report measures. A cross-lagged panel analysis was performed by including within the same model the relationships between all of the variables in the two assessment points. The results indicated cross-lagged positive relationships of self-focused positive rumination with both self-esteem and life satisfaction, while dampening showed a negative cross-lagged relationship with self-esteem. Moreover, higher self-esteem predicted more emotion-focused positive rumination, and more dampening predicted lower life satisfaction. Thus, the use of adaptive responses to positive affect and a better psychological adjustment were found to be prospectively interrelated at the one-year follow-up during middle adolescence. The discussion argues for the need to implement programmes to promote more adaptive responses to positive affect to enhance psychological adjustment in the adolescent transition to adulthood. © 2018 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  20. Medicare changes create accounting, reporting, and auditing problems. Task Force on Federal Health Care Legislation, American Institute of Certified Public Accountants.

    PubMed

    1984-11-01

    Hospital auditors and financial officers must adjust and react to the changing financial healthcare environment brought about by PPS. A close review of accounting systems, reporting methods, auditing procedures, and internal control systems should be made to determine that assets are safe-guarded and financial information is presented in conformity with GAAP. This article identified new problems and suggested solutions. Old tasks may no longer be necessary. For example, retroactive adjustments are not as important as they used to be. Estimates for capital and outpatient costs may continue to be required, but elaborate cost-finding techniques may no longer be necessary to estimate retroactive adjustments for reimbursable items. We recommend that prior to beginning an audit of a hospital's financial statements, each hospital's financial officers and its auditors discuss the possible accounting, reporting, and auditing implications as a result of PPS.

  1. Simple and flexible SAS and SPSS programs for analyzing lag-sequential categorical data.

    PubMed

    O'Connor, B P

    1999-11-01

    This paper describes simple and flexible programs for analyzing lag-sequential categorical data, using SAS and SPSS. The programs read a stream of codes and produce a variety of lag-sequential statistics, including transitional frequencies, expected transitional frequencies, transitional probabilities, adjusted residuals, z values, Yule's Q values, likelihood ratio tests of stationarity across time and homogeneity across groups or segments, transformed kappas for unidirectional dependence, bidirectional dependence, parallel and nonparallel dominance, and significance levels based on both parametric and randomization tests.

  2. Projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random networks.

    PubMed

    Feng, Cun-Fang; Xu, Xin-Jian; Wang, Sheng-Jun; Wang, Ying-Hai

    2008-06-01

    We study projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random networks. We relax some limitations of previous work, where projective-anticipating and projective-lag synchronization can be achieved only on two coupled chaotic systems. In this paper, we realize projective-anticipating and projective-lag synchronization on complex dynamical networks composed of a large number of interconnected components. At the same time, although previous work studied projective synchronization on complex dynamical networks, the dynamics of the nodes are coupled partially linear chaotic systems. In this paper, the dynamics of the nodes of the complex networks are time-delayed chaotic systems without the limitation of the partial linearity. Based on the Lyapunov stability theory, we suggest a generic method to achieve the projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random dynamical networks, and we find both its existence and sufficient stability conditions. The validity of the proposed method is demonstrated and verified by examining specific examples using Ikeda and Mackey-Glass systems on Erdos-Renyi networks.

  3. Improving precipitation forecast with hybrid 3DVar and time-lagged ensembles in a heavy rainfall event

    NASA Astrophysics Data System (ADS)

    Wang, Yuanbing; Min, Jinzhong; Chen, Yaodeng; Huang, Xiang-Yu; Zeng, Mingjian; Li, Xin

    2017-01-01

    This study evaluates the performance of three-dimensional variational (3DVar) and a hybrid data assimilation system using time-lagged ensembles in a heavy rainfall event. The time-lagged ensembles are constructed by sampling from a moving time window of 3 h along a model trajectory, which is economical and easy to implement. The proposed hybrid data assimilation system introduces flow-dependent error covariance derived from time-lagged ensemble into variational cost function without significantly increasing computational cost. Single observation tests are performed to document characteristic of the hybrid system. The sensitivity of precipitation forecasts to ensemble covariance weight and localization scale is investigated. Additionally, the TLEn-Var is evaluated and compared to the ETKF(ensemble transformed Kalman filter)-based hybrid assimilation within a continuously cycling framework, through which new hybrid analyses are produced every 3 h over 10 days. The 24 h accumulated precipitation, moisture, wind are analyzed between 3DVar and the hybrid assimilation using time-lagged ensembles. Results show that model states and precipitation forecast skill are improved by the hybrid assimilation using time-lagged ensembles compared with 3DVar. Simulation of the precipitable water and structure of the wind are also improved. Cyclonic wind increments are generated near the rainfall center, leading to an improved precipitation forecast. This study indicates that the hybrid data assimilation using time-lagged ensembles seems like a viable alternative or supplement in the complex models for some weather service agencies that have limited computing resources to conduct large size of ensembles.

  4. Urban mass transportation industry uniform system of accounts and records and reporting system. Volume IV. Reporting system forms and instructions - voluntary.

    DOT National Transportation Integrated Search

    1977-01-10

    The purpose of the report is to present and document the detailed features of the uniform system of accounts and records and reporting system required by Section 15 of the Urban Mass Transportation Act of 1964, as amended. This report is presented in...

  5. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

    PubMed Central

    Min, Jaewon; Wright, Woodring E.

    2017-01-01

    Abstract Alternative lengthening of telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in ∼15% of cancers. The potential mechanism of ALT is homology-directed telomere synthesis, but molecular mechanisms of how ALT maintains telomere length in human cancer is poorly understood. Here, we generated TERC (telomerase RNA) gene knockouts in telomerase positive cell lines that resulted in long-term surviving clones acquiring the ALT pathway but at a very low frequency. By comparing these ALT cells with parental telomerase positive cells, we observed that ALT cells possess excessively long telomeric overhangs derived from telomere elongation processes that mostly occur during S phase. ALT cells exhibited preferential elongation of the telomeric lagging strands, whereas telomerase positive cells exhibited similar elongation between leading and lagging strands. We propose that the ALT pathway preferentially occurs at telomeric lagging strands leading to heterogeneous telomere lengths observed in most ALT cancers. PMID:28082393

  6. A replication of the 5-7 day dream-lag effect with comparison of dreams to future events as control for baseline matching.

    PubMed

    Blagrove, Mark; Henley-Einion, Josie; Barnett, Amanda; Edwards, Darren; Heidi Seage, C

    2011-06-01

    The dream-lag effect refers to there being, after the frequent incorporation of memory elements from the previous day into dreams (the day-residue), a lower incorporation of memory elements from 2 to 4 days before the dream, but then an increased incorporation of memory elements from 5 to 7 days before the dream. Participants (n=8, all female) kept a daily diary and a dream diary for 14 days and then rated the level of matching between every dream report and every daily diary record. Baseline matching was assessed by comparing all dream reports to all diary records for days that occurred after the dream. A significant dream-lag effect for the 5-7 day period, compared to baseline and compared to the 2-4 day period, was found. This may indicate a memory processing function for sleep, which the dream content may reflect. Participants' and three independent judges' mean ratings also confirmed a significant day-residue effect. Copyright © 2010 Elsevier Inc. All rights reserved.

  7. Time lag between immigration and tuberculosis rates in immigrants in the Netherlands: a time-series analysis.

    PubMed

    van Aart, C; Boshuizen, H; Dekkers, A; Korthals Altes, H

    2017-05-01

    In low-incidence countries, most tuberculosis (TB) cases are foreign-born. We explored the temporal relationship between immigration and TB in first-generation immigrants between 1995 and 2012 to assess whether immigration can be a predictor for TB in immigrants from high-incidence countries. We obtained monthly data on immigrant TB cases and immigration for the three countries of origin most frequently represented among TB cases in the Netherlands: Morocco, Somalia and Turkey. The best-fit seasonal autoregressive integrated moving average (SARIMA) model to the immigration time-series was used to prewhiten the TB time series. The cross-correlation function (CCF) was then computed on the residual time series to detect time lags between immigration and TB rates. We identified a 17-month lag between Somali immigration and Somali immigrant TB cases, but no time lag for immigrants from Morocco and Turkey. The absence of a lag in the Moroccan and Turkish population may be attributed to the relatively low TB prevalence in the countries of origin and an increased likelihood of reactivation TB in an ageing immigrant population. Understanding the time lag between Somali immigration and TB disease would benefit from a closer epidemiological analysis of cohorts of Somali cases diagnosed within the first years after entry.

  8. Treatment of shift work disorder and jet lag.

    PubMed

    Zee, Phyllis C; Goldstein, Cathy A

    2010-09-01

    With the growth of the 24-hour global marketplace, a substantial proportion of workers are engaged in nontraditional work schedules and frequent jet travel across multiple time zones. Thus, shift work disorder and jet lag are prevalent in our 24/7 society and have been associated with significant health and safety repercussions. In both disorders, treatment strategies are based on promoting good sleep hygiene, improving circadian alignment, and targeting specific symptoms.Treatment of shift work must be tailored to the type of shift. For a night worker, circadian alignment can be achieved with bright light exposure during the shift and avoidance of bright light (with dark or amber sunglasses) toward the latter portion of the work period and during the morning commute home. If insomnia and/or excessive sleepiness are prominent complaints despite behavioral approaches and adequate opportunity for sleep, melatonin may be administered prior to the day sleep period to improve sleep, and alertness during work can be augmented by caffeine and wake-promoting agents.For jet lag, circadian adaptation is suggested only for travel greater than 48 h, with travel east more challenging than travel west. Although advancing sleep and wake times and circadian timing for eastward travel with evening melatonin and morning bright light several days prior to departure can help avoid jet lag at the new destination, this approach may be impractical for many people, Therefore, strategies for treatment at the destination, such as avoidance of early morning light and exposure to late-morning and afternoon light alone or in conjunction with bedtime melatonin, can accelerate re-entrainment following eastward travel. For westward travel, a circadian delay can be achieved after arrival with afternoon and early-evening light with bedtime melatonin.Good sleep hygiene practices, together with the application of circadian principles, can improve sleep quality, alertness, performance, and safety in

  9. A Report on Gender and Gender-Related Issues in the Accounting Professoriate.

    ERIC Educational Resources Information Center

    Lanier, Patricia A.; Tanner, John R.

    1999-01-01

    Responses from 188 of 500 female accounting faculty surveyed showed that only 34.3% had senior rank. Almost half earned $50,000-80,000. More than half experienced gender discrimination. They tended not to report incidents of racial or gender discrimination. (SK)

  10. Time-Lag in Responses of Birds to Atlantic Forest Fragmentation: Restoration Opportunity and Urgency.

    PubMed

    Uezu, Alexandre; Metzger, Jean Paul

    2016-01-01

    There are few opportunities to evaluate the relative importance of landscape structure and dynamics upon biodiversity, especially in highly fragmented tropical landscapes. Conservation strategies and species risk evaluations often rely exclusively on current aspects of landscape structure, although such limited assumptions are known to be misleading when time-lag responses occur. By relating bird functional-group richness to forest patch size and isolation in ten-year intervals (1956, 1965, 1978, 1984, 1993 and 2003), we revealed that birds with different sensitivity to fragmentation display contrasting responses to landscape dynamics in the Brazilian Atlantic Forest. For non-sensitive groups, there was no time-lag in response: the recent degree of isolation best explains their variation in richness, which likely relates to these species' flexibility to adapt to changes in landscape structure. However, for sensitive bird groups, the 1978 patch area was the best explanatory variable, providing evidence for a 25-year time-lag in response to habitat reduction. Time-lag was more likely in landscapes that encompass large patches, which can support temporarily the presence of some sensitive species, even when habitat cover is relatively low. These landscapes potentially support the most threatened populations and should be priorities for restoration efforts to avoid further species loss. Although time-lags provide an opportunity to counteract the negative consequences of fragmentation, it also reinforces the urgency of restoration actions. Fragmented landscapes will be depleted of biodiversity if landscape structure is only maintained, and not improved. The urgency of restoration action may be even higher in landscapes where habitat loss and fragmentation history is older and where no large fragment remained to act temporarily as a refuge.

  11. Identifying some determinants of "jet lag" and its symptoms: a study of athletes and other travellers.

    PubMed

    Waterhouse, J; Edwards, B; Nevill, A; Carvalho, S; Atkinson, G; Buckley, P; Reilly, T; Godfrey, R; Ramsay, R

    2002-02-01

    Travelling across multiple time zones disrupts normal circadian rhythms and induces "jet lag". Possible effects of this on training and performance in athletes were concerns before the Sydney Olympic Games. To identify some determinants of jet lag and its symptoms. A mixture of athletes, their coaches, and academics attending a conference (n = 85) was studied during their flights from the United Kingdom to Australia (two flights with a one hour stopover in Singapore), and for the first six days in Australia. Subjects differed in age, sex, chronotype, flexibility of sleeping habits, feelings of languor, fitness, time of arrival in Australia, and whether or not they had previous experience of travel to Australia. These variables and whether the body clock adjusted to new local time by phase advance or delay were tested as predictors for jet lag and some of its symptoms by stepwise multiple regression analyses. The amount of sleep in the first flight was significantly greater in those who had left the United Kingdom in the evening than the morning (medians of 5.5 hours and 1.5 hours respectively; p = 0.0002, Mann-Whitney), whereas there was no significant difference on the second flight (2.5 hours v 2.8 hours; p = 0.72). Only the severity of jet lag and assessments of sleep and fatigue were commonly predicted significantly (p<0.05) by regression analysis, and then by only some of the variables. Thus increasing age and a later time of arrival in Australia were associated with less jet lag and fatigue, and previous experience of travel to Australia was associated with an earlier time of getting to sleep. Subjects who had adjusted by phase advance suffered worse jet lag during the 5th and 6th days in Australia. These results indicate the importance of an appropriate choice of itinerary and lifestyle for reducing the negative effects of jet lag in athletes and others who wish to perform optimally in the new time zone.

  12. Time-lag properties of corona streamer discharges between impulse sphere and dc needle electrodes under atmospheric air conditions.

    PubMed

    Okano, Daisuke

    2013-02-01

    In this study of corona streamer discharges from an impulse generator using a dc power supply, the relationship of the discharge time-lag with the dc bias voltage between the sphere-to-needle electrodes under atmospheric conditions is investigated. Devices utilizing corona discharges have been used to purify air or water, destroy bacteria, and to remove undesirable substances, and in order to achieve fast response times and high power efficiencies in such devices, it is important to minimize the time-lag of the corona discharge. Our experimental results show that (a) the discharge path of a negatively biased needle electrode will be straighter than that of a positively biased needle and (b) the discharge threshold voltage in both the positive and the negative needle electrodes is nearly equal to 33 kV. By expressing the discharge voltage as a power function of time-lag, the extent of corona generation can be quantitatively specified using the exponent of this power function. The observed behavior of a corona streamer discharge between the negative spherical and the positive needle electrodes indicates that the largest power exponent is associated with the shortest time-lag, owing to the reduction in the statistical time-lag in the absence of a formative time-lag.

  13. Time-lag properties of corona streamer discharges between impulse sphere and dc needle electrodes under atmospheric air conditions

    NASA Astrophysics Data System (ADS)

    Okano, Daisuke

    2013-02-01

    In this study of corona streamer discharges from an impulse generator using a dc power supply, the relationship of the discharge time-lag with the dc bias voltage between the sphere-to-needle electrodes under atmospheric conditions is investigated. Devices utilizing corona discharges have been used to purify air or water, destroy bacteria, and to remove undesirable substances, and in order to achieve fast response times and high power efficiencies in such devices, it is important to minimize the time-lag of the corona discharge. Our experimental results show that (a) the discharge path of a negatively biased needle electrode will be straighter than that of a positively biased needle and (b) the discharge threshold voltage in both the positive and the negative needle electrodes is nearly equal to 33 kV. By expressing the discharge voltage as a power function of time-lag, the extent of corona generation can be quantitatively specified using the exponent of this power function. The observed behavior of a corona streamer discharge between the negative spherical and the positive needle electrodes indicates that the largest power exponent is associated with the shortest time-lag, owing to the reduction in the statistical time-lag in the absence of a formative time-lag.

  14. Accounting for Uncertainty and Time Lags in Equivalency Calculations for Offsetting in Aquatic Resources Management Programs

    NASA Astrophysics Data System (ADS)

    Bradford, Michael J.

    2017-10-01

    Biodiversity offset programs attempt to minimize unavoidable environmental impacts of anthropogenic activities by requiring offsetting measures in sufficient quantity to counterbalance losses due to the activity. Multipliers, or offsetting ratios, have been used to increase the amount of offsets to account for uncertainty but those ratios have generally been derived from theoretical or ad-hoc considerations. I analyzed uncertainty in the offsetting process in the context of offsetting for impacts to freshwater fisheries productivity. For aquatic habitats I demonstrate that an empirical risk-based approach for evaluating prediction uncertainty is feasible, and if data are available appropriate adjustments to offset requirements can be estimated. For two data-rich examples I estimate multipliers in the range of 1.5:1 - 2.5:1 are sufficient to account for the uncertainty in the prediction of gains and losses. For aquatic habitats adjustments for time delays in the delivery of offset benefits can also be calculated and are likely smaller than those for prediction uncertainty. However, the success of a biodiversity offsetting program will also depend on the management of the other components of risk not addressed by these adjustments.

  15. Accounting for Uncertainty and Time Lags in Equivalency Calculations for Offsetting in Aquatic Resources Management Programs.

    PubMed

    Bradford, Michael J

    2017-10-01

    Biodiversity offset programs attempt to minimize unavoidable environmental impacts of anthropogenic activities by requiring offsetting measures in sufficient quantity to counterbalance losses due to the activity. Multipliers, or offsetting ratios, have been used to increase the amount of offsets to account for uncertainty but those ratios have generally been derived from theoretical or ad-hoc considerations. I analyzed uncertainty in the offsetting process in the context of offsetting for impacts to freshwater fisheries productivity. For aquatic habitats I demonstrate that an empirical risk-based approach for evaluating prediction uncertainty is feasible, and if data are available appropriate adjustments to offset requirements can be estimated. For two data-rich examples I estimate multipliers in the range of 1.5:1 - 2.5:1 are sufficient to account for the uncertainty in the prediction of gains and losses. For aquatic habitats adjustments for time delays in the delivery of offset benefits can also be calculated and are likely smaller than those for prediction uncertainty. However, the success of a biodiversity offsetting program will also depend on the management of the other components of risk not addressed by these adjustments.

  16. A cross-lagged model of the reciprocal associations of loneliness and memory functioning.

    PubMed

    Ayalon, Liat; Shiovitz-Ezra, Sharon; Roziner, Ilan

    2016-05-01

    The study was designed to evaluate the reciprocal associations of loneliness and memory functioning using a cross-lagged model. The study was based on the psychosocial questionnaire of the Health and Retirement Study, which is a U.S. nationally representative survey of individuals over the age of 50 and their spouses of any age. A total of 1,225 respondents had complete data on the loneliness measure in 2004 and at least in 1 of the subsequent waves (e.g., 2008, 2012) and were maintained for analysis. A cross-lagged model was estimated to examine the reciprocal associations of loneliness and memory functioning, controlling for age, gender, education, depressive symptoms, number of medical conditions, and the number of close social relationships. The model had adequate fit indices: χ2(860, N = 1,225) = 1,401.54, p < .001, Tucker-Lewis index = .957, comparative fit index = .963, and root mean square error of approximation = .023 (90% confidence interval [.021, .025]). The lagged effect of loneliness on memory functioning was nonsignificant, B(SE) = -.11(.08), p = .15, whereas the lagged effect of memory functioning on loneliness was significant, B(SE) = -.06(.02), p = .01, indicating that lower levels of memory functioning precede higher levels of loneliness 4 years afterward. Further research is required to better understand the mechanisms responsible for the temporal association between reduced memory functioning and increased loneliness. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. IX. 10 New Observations of Reverberation Mapping and Shortened Hβ Lags

    NASA Astrophysics Data System (ADS)

    Du, Pu; Zhang, Zhi-Xiang; Wang, Kai; Huang, Ying-Ke; Zhang, Yue; Lu, Kai-Xing; Hu, Chen; Li, Yan-Rong; Bai, Jin-Ming; Bian, Wei-Hao; Yuan, Ye-Fei; Ho, Luis C.; Wang, Jian-Min; SEAMBH collaboration

    2018-03-01

    As one paper in a series reporting on a large reverberation mapping campaign of super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs), we present the results of 10 SEAMBHs monitored spectroscopically during 2015–2017. Six of them are observed for the first time, and have generally higher 5100 Å luminosities than the SEAMBHs monitored in our campaign from 2012 to 2015; the remaining four are repeat observations to check if their previous lags change. Similar to the previous SEAMBHs, the Hβ time lags of the newly observed objects are shorter than the values predicted by the canonical R Hβ –L 5100 relation of sub-Eddington AGNs, by factors of ∼2–6, depending on the accretion rate. The four previously observed objects have lags consistent with previous measurements. We provide linear regressions for the R Hβ –L 5100 relation, solely for the SEAMBH sample and for low-accretion AGNs. We find that the relative strength of Fe II and the profile of the Hβ emission line can be used as proxies of accretion rate, showing that the shortening of Hβ lags depends on accretion rates. The recent SDSS-RM discovery of shortened Hβ lags in AGNs with low accretion rates provides compelling evidence for retrograde accretion onto the black hole. These evidences show that the canonical R Hβ –L 5100 relation holds only in AGNs with moderate accretion rates. At low accretion rates, it should be revised to include the effects of black hole spin, whereas the accretion rate itself becomes a key factor in the regime of high accretion rates.

  18. Characteristics associated with Sleep Duration, Chronotype, and Social jet lag in Adolescents

    PubMed Central

    Malone, Susan Kohl; Zemel, Babette S.; Compher, Charlene; Souders, Margaret; Chittams, Jesse; Thompson, Aleda Leis; Lipman, Terri H.

    2015-01-01

    Sleep is a complex behavior with numerous health implications. Identifying socio-demographic and behavioral characteristics of sleep are important for determining those at greatest risk for sleep-related health disparities. In this cross-sectional study, general linear models were used to examine socio-demographic and behavioral characteristics associated with sleep duration, chronotype, and social jet lag in adolescents. One hundred fifteen participants completed Phase I (self-reported sleep measures); 69 of these participants completed Phase II (actigraphy-estimated sleep measures). Black adolescents had shorter free night sleep than Hispanics. Youth with later chronotypes ate fewer fruits and vegetables, drank more soda, were less physically active, and took more daytime naps. Based on these findings, recommendations for individual support and school policies are provided. PMID:26376832

  19. An Evaluation of a Phase-Lag Boundary Condition for Francis Hydroturbine Simulations Using a Pressure-Based Solver

    NASA Astrophysics Data System (ADS)

    Wouden, Alex; Cimbala, John; Lewis, Bryan

    2014-11-01

    While the periodic boundary condition is useful for handling rotational symmetry in many axisymmetric geometries, its application fails for analysis of rotor-stator interaction (RSI) in multi-stage turbomachinery flow. The inadequacy arises from the underlying geometry where the blade counts per row differ, since the blade counts are crafted to deter the destructive harmonic forces of synchronous blade passing. Therefore, to achieve the computational advantage of modeling a single blade passage per row while preserving the integrity of the RSI, a phase-lag boundary condition is adapted to OpenFOAM® software's incompressible pressure-based solver. The phase-lag construct is accomplished through restating the implicit periodic boundary condition as a constant boundary condition that is updated at each time step with phase-shifted data from the coupled cells adjacent to the boundary. Its effectiveness is demonstrated using a typical Francis hydroturbine modeled as single- and double-passages with phase-lag boundary conditions. The evaluation of the phase-lag condition is based on the correspondence of the overall computational performance and the calculated flow parameters of the phase-lag simulations with those of a baseline full-wheel simulation. Funded in part by DOE Award Number: DE-EE0002667.

  20. LAG-3 in Non-Small-cell Lung Cancer: Expression in Primary Tumors and Metastatic Lymph Nodes Is Associated With Improved Survival.

    PubMed

    Hald, Sigurd M; Rakaee, Mehrdad; Martinez, Inigo; Richardsen, Elin; Al-Saad, Samer; Paulsen, Erna-Elise; Blix, Egil Støre; Kilvaer, Thomas; Andersen, Sigve; Busund, Lill-Tove; Bremnes, Roy M; Donnem, Tom

    2018-05-01

    Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint receptor and a putative therapeutic target in non-small-cell lung cancer (NSCLC). We explored the prognostic effect of LAG-3 + tumor-infiltrating lymphocytes (TILs) in primary tumors and metastatic lymph nodes in NSCLC and its potential for inclusion in an immunoscore, supplementing the TNM classification. Primary tumor tissue from 553 stage I-IIIB NSCLC patients and 143 corresponding metastatic lymph nodes were collected. The expression of LAG-3 was evaluated by immunohistochemistry on tissue microarrays. On univariate analysis, LAG-3 + TILs in the intraepithelial and stromal compartments of primary tumors and in the intraepithelial and extraepithelial compartments of metastatic lymph nodes were associated with improved disease-specific survival (DSS). On multivariate analysis, stromal LAG-3 + TILs were a significant independent predictor of improved DSS (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.43-0.82; P = .002). Stromal LAG-3 + TILs did not have prognostic impact across all pathologic stages. In the metastatic lymph nodes, intraepithelial (HR, 0.61; 95% CI, 0.38-0.99; P = .049) and extraepithelial (HR, 0.54; 95% CI, 0.29-0.70; P < .001) LAG-3 + TILs were independently associated with favorable DSS. LAG-3 + TILs are an independent positive prognostic factor in stage I-IIIB NSCLC. LAG-3 in metastatic lymph nodes is a candidate marker for an immunoscore in NSCLC. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Lag-driven motion in front propagation

    NASA Astrophysics Data System (ADS)

    Amor, Daniel R.; Fort, Joaquim

    2013-10-01

    Front propagation is a ubiquitous phenomenon. It arises in physical, biological and cross-disciplinary systems as diverse as flame propagation, superconductors, virus infections, cancer spread or transitions in human prehistory. Here we derive a single, approximate front speed from three rather different time-delayed reaction-diffusion models, suggesting a general law. According to our approximate speed, fronts are crucially driven by the lag times (periods during which individuals or particles do not move). Rather surprisingly, the approximate speed is able to explain the observed spread rates of completely different biophysical systems such as virus infections, the Neolithic transition in Europe, and postglacial tree recolonizations.

  2. [Odontoid bending stiffness after anterior fixation with a single lag screw: biomechanical study].

    PubMed

    Buchvald, P; Čapek, L; Barsa, P

    2015-01-01

    PURPOSE OF THE STUDY The aim of the experiment was to compare the bending stiffness of an intact odontoid process with bending stiffness after its simulated type II fracture was fixed with a single lag screw. The experiment was done with a desire to answer the question of whether a single osteosynthetic screw is sufficient for good fixation of a type II odontoid fracture. MATERIAL AND METHODS The C2 vertebrae of six cadavers were used. With simultaneous measurement of odontoid bending stiffness, the occurrence of a fracture (type IIA, Grauer's modification of the Anderson- D'Alonzo classification) was simulated using action exerted by a tearing machine in the direction perpendicular to the odontoid axis. Each odontoid fracture was subsequently treated by direct osteosynthesis with a single lag screw inserted in the axial direction by a standard surgical procedure in order to provide conditions similar to those achieved by routine surgical management. The treated odontoid process was subsequently subjected to the same tearing machine loading as applied to it at the start of the experiment. The bending stiffness measured was then compared with that found before the fracture occurred. The results were statistically evaluated by the t-test for paired samples at the level of significance α = 0.05. RESULTS The average value of bending stiffness for odontoid processes of intact vertebrae at the moment of fracture occurrence was 318.3 N/mm. After single axial lag screw fixation of the fracture, the average bending stiffness for the odontoid processes treated was 331.3 N/mm. DISCUSSION Higher values of bending stiffness after screw fixation were found in all specimens and, in comparison with the values recorded before simulated fractures, the increase was statistically significant. CONCLUSIONS The results of our measurements suggest that the single lag screw fixation of a type IIA odontoid fracture will provide better stability for the fracture fragment-C2 body complex on

  3. Identifying increased risk of post-infarct people with diabetes using multi-lag Tone-Entropy analysis.

    PubMed

    Karmakar, Chandan; Jelinek, Herbert; Khandoker, Ahsan; Tulppo, Mikko; Makikallio, Timo; Kiviniemi, Antti; Huikuri, Heikki; Palaniswami, Marimuthu

    2012-01-01

    Diabetes mellitus is associated with multi-organ system dysfunction. One of the key causative factors is the increased blood sugar level that leads to an increase in free radical activity and organ damage including the cardiovascular and nervous system. Heart rhythm is extrinsically modulated by the autonomic nervous system and cardiac autonomic neuropathy or dysautonomia has been shown to lead to sudden cardiac death in people with diabetes due to the decrease in heart rate variability (HRV). Current algorithms for determining HRV describe only beat-to-beat variation and therefore do not consider the ability of a heart beat to influence a train of succeeding beats. Therefore mortality risk analysis based on HRV has often not been able to discern the presence of an increased risk. This study used a novel innovation of the tone-entropy algorithm by incorporating increased lag intervals and found that both the sympatho-vagal balance and total activity changed at larger lag intervals. Tone-Entropy was found to be better risk identifier of cardiac mortality in people with diabetes at lags higher than one and best at lag seven.

  4. A FOURIER-TRANSFORMED BREMSSTRAHLUNG FLASH MODEL FOR THE PRODUCTION OF X-RAY TIME LAGS IN ACCRETING BLACK HOLE SOURCES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kroon, John J.; Becker, Peter A., E-mail: jkroon@gmu.edu, E-mail: pbecker@gmu.edu

    Accreting black hole sources show a wide variety of rapid time variability, including the manifestation of time lags during X-ray transients, in which a delay (phase shift) is observed between the Fourier components of the hard and soft spectra. Despite a large body of observational evidence for time lags, no fundamental physical explanation for the origin of this phenomenon has been presented. We develop a new theoretical model for the production of X-ray time lags based on an exact analytical solution for the Fourier transform describing the diffusion and Comptonization of seed photons propagating through a spherical corona. The resultingmore » Green's function can be convolved with any source distribution to compute the associated Fourier transform and time lags, hence allowing us to explore a wide variety of injection scenarios. We show that thermal Comptonization is able to self-consistently explain both the X-ray time lags and the steady-state (quiescent) X-ray spectrum observed in the low-hard state of Cyg X-1. The reprocessing of bremsstrahlung seed photons produces X-ray time lags that diminish with increasing Fourier frequency, in agreement with the observations for a wide range of sources.« less

  5. Lag-length effect on repetition priming of famous and unfamiliar faces: evidence from N250r and N400.

    PubMed

    Nie, Aiqing; Li, Minye; Ye, Jingheng

    2016-07-06

    Previous event-related potentials research has reliably identified two repetition priming components in faces, the N250r and the N400, which are believed to reflect, respectively, the accessing to the stored structural representations and the semantic retrieval. However, the effect of lags longer than immediate repetition and shorter than 3 min on the two components has not been described as yet, and the interaction between lag length and familiarity is unclear. The current experiment aims to address these issues. In this experiment, famous and unfamiliar faces were represented after short, medium, or long lags, and participants were required to decide whether each face was known or not. The data showed that the frontal N250r, rather than the temporal counterpart, persisted to the medium lag case for famous faces; for unfamiliar faces, no N250r was observed. The frontal N400 was more regulated by lag length than the centroparietal counterpart. These results suggest that the frontal N250r and the frontal N400 are affected by the lag length; moreover, the former is more sensitive to the pre-experimental familiarity of faces.

  6. Growth-incompetent monomers of human calcitonin lead to a noncanonical direct relationship between peptide concentration and aggregation lag time.

    PubMed

    Kamgar-Parsi, Kian; Hong, Liu; Naito, Akira; Brooks, Charles L; Ramamoorthy, Ayyalusamy

    2017-09-08

    The role of the peptide hormone calcitonin in skeletal protection has led to its use as a therapeutic for osteoporosis. However, calcitonin aggregation into amyloid fibrils limits its therapeutic efficacy, necessitating a modification of calcitonin's aggregation kinetics. Here, we report a direct relationship between human calcitonin (hCT) concentration and aggregation lag time. This kinetic trend was contrary to the conventional understanding of amyloid aggregation and persisted over a range of aggregation conditions, as confirmed by thioflavin-T kinetics assays, CD spectroscopy, and transmission EM. Dynamic light scattering, 1 H NMR experiments, and seeded thioflavin-T assay results indicated that differences in initial peptide species contribute to this trend more than variations in the primary nucleus formation rate. On the basis of kinetics modeling results, we propose a mechanism whereby a structural conversion of hCT monomers is needed before incorporation into the fibril. Our kinetic mechanism recapitulates the experimentally observed relationship between peptide concentration and lag time and represents a novel mechanism in amyloid aggregation. Interestingly, hCT at low pH and salmon calcitonin (sCT) exhibited the canonical inverse relationship between concentration and lag time. Comparative studies of hCT and sCT with molecular dynamics simulations and CD indicated an increased α-helical structure in sCT and low-pH hCT monomers compared with neutral-pH hCT, suggesting that α-helical monomers represent a growth-competent species, whereas unstructured random coil monomers represent a growth-incompetent species. Our finding that initial monomer concentration is positively correlated with lag time in hCT aggregation could help inform future efforts for improving therapeutic applications of CT. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  7. Lag and light-transfer characteristics of amorphous selenium photoconductive film with tellurium-doped layer

    NASA Astrophysics Data System (ADS)

    Park, Wug-Dong; Tanioka, Kenkichi

    2016-07-01

    Amorphous selenium (a-Se) high-gain avalanche rushing amorphous photoconductor (HARP) films have been used for highly sensitive imaging devices. To study a-Se HARP films for a solid-state image sensor, current-voltage, lag, spectral response, and light-transfer characteristics of 0.4-µm-thick a-Se HARP films are investigated. Also, to clarify a suitable Te-doped a-Se layer thickness in the a-Se photoconductor, we considered the effects of Te-doped layer thickness on the lag, spectral response, and light-transfer characteristics of 0.4-µm-thick a-Se HARP films. The threshold field, at which avalanche multiplication occurs in the a-Se HARP targets, decreases when the Te-doped layer thickness increases. The lag of 0.4-µm-thick a-Se HARP targets with Te-doped layers is higher than that of the target without Te doping. The lag of the targets with Te-doped layers is caused by the electrons trapped in the Te-doped layers within the 0.4-µm-thick a-Se HARP films. From the results of the spectral response measurement of about 15 min, the 0.4-µm-thick a-Se HARP targets with Te-doped layers of 90 and 120 nm are observed to be unstable owing to the electrons trapped in the Te-doped a-Se layer. From the light-transfer characteristics of 0.4-µm-thick a-Se HARP targets, as the slope at the operating point of signal current-voltage characteristics in the avalanche mode increases, the γ of the a-Se HARP targets decreases. Considering the effects of dark current on the lag and spectral response characteristics, a Te-doped layer of 60 nm is suitable for 0.4-µm-thick a-Se HARP films.

  8. TIDAL FRICTION AND TIDAL LAGGING. APPLICABILITY LIMITATIONS OF A POPULAR FORMULA FOR THE TIDAL TORQUE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Efroimsky, Michael; Makarov, Valeri V., E-mail: michael.efroimsky@usno.navy.mil, E-mail: vvm@usno.navy.mil

    Tidal torques play a key role in rotational dynamics of celestial bodies. They govern these bodies' tidal despinning and also participate in the subtle process of entrapment of these bodies into spin-orbit resonances. This makes tidal torques directly relevant to the studies of habitability of planets and their moons. Our work begins with an explanation of how friction and lagging should be built into the theory of bodily tides. Although much of this material can be found in various publications, a short but self-consistent summary on the topic has been lacking in the hitherto literature, and we are filling themore » gap. After these preparations, we address a popular concise formula for the tidal torque, which is often used in the literature, for planets or stars. We explain why the derivation of this expression, offered in the paper by Goldreich and in the books by Kaula (Equation (4.5.29)) and Murray and Dermott (Equation (4.159)), implicitly sets the time lag to be frequency independent. Accordingly, the ensuing expression for the torque can be applied only to bodies having a very special (and very hypothetical) rheology which makes the time lag frequency independent, i.e., the same for all Fourier modes in the spectrum of tide. This expression for the torque should not be used for bodies of other rheologies. Specifically, the expression cannot be combined with an extra assertion of the geometric lag being constant, because at finite eccentricities the said assumption is incompatible with the constant-time-lag condition.« less

  9. Evaluation of a Lag Schedule of Reinforcement in a Group Contingency to Promote Varied Naming of Categories Items with Children

    ERIC Educational Resources Information Center

    Wiskow, Katie M.; Donaldson, Jeanne M.

    2016-01-01

    We compared the effects of Lag 0 and Lag 1 schedules of reinforcement on children's responses naming category items in a group context and subsequent responses emitted during individual testing in which the schedule of reinforcement remained Lag 0. Specifically, we measured response variability and novel responses to categories for 3 children who…

  10. Humanitarian accountability, bureaucracy, and self-regulation: the view from the archive.

    PubMed

    Roddy, Sarah; Strange, Julie-Marie; Taithe, Bertrand

    2015-10-01

    This paper contains a systematic exploration of local and national archives and sources relevant to charities and humanitarian fund appeals of the late Victorian and Edwardian eras (1870-1912) in Great Britain. It shows that the charitable world and humanitarian work share the same matrix and originate from the same roots, with considerable overlap between fundraising for domestic charity and overseas relief. These campaigns engaged in crucial self-regulatory processes very early on that involved concepts such as formal accountability and the close monitoring of delivery. Far from lagging behind in terms of formal practices of auditing and accounts, charities and humanitarian funds often were in the pioneering group as compared with mainstream businesses of the period. The charitable sector, notably through the Charity Organisation Society in cooperation with the press, developed and delivered accountability and monitoring, while the state and the Charity Commission played a negligible role in this process. © 2015 The Author(s). Disasters © Overseas Development Institute, 2015.

  11. Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients.

    PubMed

    Ma, Qiang; Liu, Junning; Wu, Guoliang; Teng, Mujian; Wang, Shaoxuan; Cui, Meng; Li, Yuantao

    2018-06-15

    Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3 +  Treg accumulation in the tumor was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients. Compared to controls, CRC patients presented mild upregulations in CD4 + CD25 +/hi T cells and in the more canonical CD4 + CD25 +/hi Foxp3 + Treg cells in peripheral blood mononuclear cells. Both of these Treg populations could be roughly divided into LAG3 - TIM3 - and LAG3 + TIM3 + subsets. In CRC patients, the LAG3 + TIM3 + subset represented approximately half of CD4 + CD25 +/hi T cells and greater than 60% of CD4 + CD25 +/hi Foxp3 + Treg cells, which was significantly more frequent than in healthy controls. Compared to the LAG3 - TIM3 - CD4 + CD25 +/hi T cells, the LAG3 + TIM3 + CD4 + CD25 +/hi T cells presented considerably higher transforming growth factor (TGF)-β and slightly higher interleukin (IL)-10 secretion, together with higher CTLA-4 and Foxp3 expression levels. Notably, macrophages following incubation with LAG3 - TIM3 - CD4 + CD25 +/hi T cells and LAG3 + TIM3 + CD4 + CD25 +/hi T cells displayed different characteristics. Macrophages incubated with LAG3 + TIM3 + CD4 + CD25 +/hi T cells presented lower expression of MHC class II, CD80, CD86, and tumor necrosis factor alpha (TNFα) but higher expression of IL-10, than macrophages incubated with LAG3 - TIM3 - CD4 + CD25 +/hi T cells. Together, our investigations demonstrated that CRC patients presented an enrichment of circulating Treg cells, in which the LAG3 + TIM3 + subset exhibited more potent expression of inhibitory molecules, and furthermore, the LAG3 + TIM3 + Treg cells could suppress the proinflammatory activation of macrophages more potently than the LAG3 - TIM3 - Treg cells. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Development and validation of a short-lag spatial coherence theory for photoacoustic imaging

    NASA Astrophysics Data System (ADS)

    Graham, Michelle T.; Lediju Bell, Muyinatu A.

    2018-02-01

    We previously derived spatial coherence theory to be implemented for studying theoretical properties of ShortLag Spatial Coherence (SLSC) beamforming applied to photoacoustic images. In this paper, our newly derived theoretical equation is evaluated to generate SLSC images of a point target and a 1.2 mm diameter target and corresponding lateral profiles. We compared SLSC images simulated solely based on our theory to SLSC images created after beamforming acoustic channel data from k-Wave simulations of 1.2 mm-diameter disc target. This process was repeated for a point target and the full width at half the maximum signal amplitudes were measured to estimate the resolution of each imaging system. Resolution as a function of lag was comparable for the first 10% of the receive aperture (i.e., the short-lag region), after which resolution measurements diverged by a maximum of 1 mm between the two types of simulated images. These results indicate the potential for both simulation methods to be utilized as independent resources to study coherence-based photoacoustic beamformers when imaging point-like targets.

  13. Report Says Colleges Bilking Loan Program: A Report from the Government Accountability Office of the United States

    ERIC Educational Resources Information Center

    Pekow, Charles

    2005-01-01

    A program designed to provide student aid has spun out of control, becoming a cash cow for colleges and universities. The Department of Education has not adequately controlled the Federal Family Education Loan Program (FFELP), according to a recent report from the Government Accountability Office (GAO). Originally, traditional lending institutions…

  14. Time-lag of the earthquake energy release between three seismic regions

    NASA Astrophysics Data System (ADS)

    Tsapanos, Theodoros M.; Liritzis, Ioannis

    1992-06-01

    Three complete data sets of strong earthquakes ( M≥5.5), which occurred in the seismic regions of Chile, Mexico and Kamchatka during the time period 1899 1985, have been used to test the existence of a time-lag in the seismic energy release between these regions. These data sets were cross-correlated in order to determine whether any pair of the sets are correlated. For this purpose statistical tests, such as the T-test, the Fisher's transformation and probability distribution have been applied to determine the significance of the obtained correlation coefficients. The results show that the time-lag between Chile and Kamchatka is -2, which means that Kamchatka precedes Chile by 2 years, with a correlation coefficient significant at 99.80% level, a weak correlation between Kamchatka-Mexico and noncorrelation for Mexico-Chile.

  15. Searching for Accountability, Productivity, Etc., Etc. Accounting and Financial Reporting.

    ERIC Educational Resources Information Center

    Piotrowski, Craig

    1988-01-01

    School districts are being asked to provide expanded variety and quality of educational services with fewer tax dollars. Discusses the search for accountability, productivity, quality, and equity in education and alerts school business officials to the problems and conflicts inherent in such a search. (MLF)

  16. Utilization of the Bridging Strategy for the Development of New Drugs in Oncology to Avoid Drug Lag.

    PubMed

    Kogure, Seiji; Koyama, Nobuyuki; Hidaka, Shinji

    2017-11-01

    Global trial (GT) strategy and bridging (BG) strategy are currently the main clinical development strategies of oncology drugs in Japan, but the relationship between development style and drug lag and how the bridging strategy has contributed to the solution of drug lag have not been clear. We investigated the potential factors that influenced submission lag (SL), and also compared the differences in SL among early-initiation BG strategy, late-initiation BG strategy, and GT strategy. A stepwise linear regression analysis identified the potential factors that shorten SL: development start lag and development style. Comparison of the differences in SL among the strategies also indicated that the SL in the GT strategy and that in the early-initiation BG strategy were significantly shorter than that in the late-initiation BG strategy. The findings in our study suggest that the late-initiation BG strategy may not contribute to shortening drug lag. Because the number of late-initiation BG studies has not decreased, we propose first that pharmaceutical companies should initiate clinical development as early as possible in Japan so that they can choose the GT strategy as a first option at the next step, and second when they cannot choose the GT strategy after investigating differences in exposure between Japanese and non-Japanese in a phase 1 study, they should select the early BG strategy to avoid future drug lag. It is also important for the regulatory authorities to provide reasonable guidance to have a positive impact on strategic decisions, even for foreign-capital companies. © 2017, The American College of Clinical Pharmacology.

  17. An improved measurement system for FOG pure lag time with no changing of FOG work status

    NASA Astrophysics Data System (ADS)

    Chen, X.; Yang, J. H.; Zhou, Y. L.; Shu, X. W.

    2018-05-01

    The minimum pure lag time is an important factor for characterizing the dynamic performance of fiber optical gyroscope. It is defined as the time duration from the reception of velocity-shock signal to the output of corresponding fiber-optic gyroscope data. Many engineering projects have required for this index specifically, so the measurement of the minimum pure lag time is highly demanded. In typically measurement system, the work status of tested FOG has to be changed. In this work, a FOG pure lag time measurement system without changing the work status of the FOG has been demonstrated. During the operation of this test system, the impact structure generated a shock towards the FOG, and the pure lag time was measured through data processing analysis. The design scheme and test principle have been researched and analyzed in detail. And a prototype has been developed and used for experiment successfully. This measurement system can realize a measurement accuracy of better than ±3 μs and a system resolution of 108.6ns.

  18. A study of the cross-correlation and time lag in black hole X-ray binary XTE J1859+226

    NASA Astrophysics Data System (ADS)

    Pei, Songpeng; Ding, Guoqiang; Li, Zhibing; Lei, Yajuan; Yuen, Rai; Qu, Jinlu

    2017-07-01

    With Rossi X-ray Timing Explorer (RXTE) data, we systematically study the cross-correlation and time lag in all spectral states of black hole X-ray binary (BHXB) XTE J1859+226 in detail during its entire 1999-2000 outburst that lasted for 166 days. Anti-correlations and positive correlations and their respective soft and hard X-ray lags are only detected in the first 100 days of the outburst when the luminosity is high. This suggests that the cross-correlations may be related to high luminosity. Positive correlations are detected in every state of XTE J1859+226, viz., hard state, hard-intermediate state (HIMS), soft-intermediate state (SIMS) and soft state. However, anti-correlations are only detected in HIMS and SIMS, anti-correlated hard lags are only detected in SIMS, while anti-correlated soft lags are detected in both HIMS and SIMS. Moreover, the ratio of the observations with anti-correlated soft lags to hard lags detected in XTE J1859+226 is significantly different from that in neutron star low-mass X-ray binaries (NS LMXBs). So far, anti-correlations are never detected in the soft state of BHXBs but detected in every branch or state of NS LMXBs. This may be due to the origin of soft seed photons in BHXBs is confined to the accretion disk and, for NS LMXBs, from both accretion disk and the surface of the NS. We notice that the timescale of anti-correlated time lags detected in XTE J1859+226 is similar with that of other BHXBs and NS LMXBs. We suggest that anti-correlated soft lag detected in BHXB may result from fluctuation in the accretion disk as well as NS LMXB.

  19. Mathematical Creativity and Mathematical Aptitude: A Cross-Lagged Panel Analysis

    ERIC Educational Resources Information Center

    Tyagi, Tarun Kumar

    2016-01-01

    Cross-lagged panel correlation (CLPC) analysis has been used to identify causal relationships between mathematical creativity and mathematical aptitude. For this study, 480 8th standard students were selected through a random cluster technique from 9 intermediate and high schools of Varanasi, India. Mathematical creativity and mathematical…

  20. Assessment of the Accounting and Joint Accounting/Computer Information Systems Programs.

    ERIC Educational Resources Information Center

    Appiah, John; Cernigliaro, James; Davis, Jeffrey; Gordon, Millicent; Richards, Yves; Santamaria, Fernando; Siegel, Annette; Lytle, Namy; Wharton, Patrick

    This document presents City University of New York LaGuardia Community College's Department of Accounting and Managerial Studies assessment of its accounting and joint accounting/computer information systems programs report, and includes the following items: (1) description of the mission and goals of the Department of Accounting and Managerial…

  1. Distributed lags time series analysis versus linear correlation analysis (Pearson's r) in identifying the relationship between antipseudomonal antibiotic consumption and the susceptibility of Pseudomonas aeruginosa isolates in a single Intensive Care Unit of a tertiary hospital.

    PubMed

    Erdeljić, Viktorija; Francetić, Igor; Bošnjak, Zrinka; Budimir, Ana; Kalenić, Smilja; Bielen, Luka; Makar-Aušperger, Ksenija; Likić, Robert

    2011-05-01

    The relationship between antibiotic consumption and selection of resistant strains has been studied mainly by employing conventional statistical methods. A time delay in effect must be anticipated and this has rarely been taken into account in previous studies. Therefore, distributed lags time series analysis and simple linear correlation were compared in their ability to evaluate this relationship. Data on monthly antibiotic consumption for ciprofloxacin, piperacillin/tazobactam, carbapenems and cefepime as well as Pseudomonas aeruginosa susceptibility were retrospectively collected for the period April 2006 to July 2007. Using distributed lags analysis, a significant temporal relationship was identified between ciprofloxacin, meropenem and cefepime consumption and the resistance rates of P. aeruginosa isolates to these antibiotics. This effect was lagged for ciprofloxacin and cefepime [1 month (R=0.827, P=0.039) and 2 months (R=0.962, P=0.001), respectively] and was simultaneous for meropenem (lag 0, R=0.876, P=0.002). Furthermore, a significant concomitant effect of meropenem consumption on the appearance of multidrug-resistant P. aeruginosa strains (resistant to three or more representatives of classes of antibiotics) was identified (lag 0, R=0.992, P<0.001). This effect was not delayed and it was therefore identified both by distributed lags analysis and the Pearson's correlation coefficient. Correlation coefficient analysis was not able to identify relationships between antibiotic consumption and bacterial resistance when the effect was delayed. These results indicate that the use of diverse statistical methods can yield significantly different results, thus leading to the introduction of possibly inappropriate infection control measures. Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  2. Phase lag deduced information in photo-thermal actuation for nano-mechanical systems characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bijster, R. J. F., E-mail: roy.bijster@tno.nl; Vreugd, J. de; Sadeghian, H.

    2014-08-18

    In photo-thermal actuation, heat is added locally to a micro-cantilever by means of a laser. A fraction of the irradiation is absorbed, yielding thermal stresses and deformations in the structure. Harmonic modulation of the laser power causes the cantilever to oscillate. Moreover, a phase lag is introduced which is very sensitive to the spot location and the cantilever properties. This phase lag is theoretically predicted and experimentally verified. Combined with thermo-mechanical properties of the cantilever and its geometry, the location of the laser spot, the thermal diffusivity, and the layer thicknesses of the cantilever can be extracted.

  3. Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters.

    PubMed

    Gibson, Erin M; Wang, Connie; Tjho, Stephanie; Khattar, Neera; Kriegsfeld, Lance J

    2010-12-01

    Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined. In the present study, we investigated whether experimental 'jet lag' (i.e., phase advances of the light:dark cycle) negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function. Together, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.

  4. Urban mass transportation industry uniform system of accounts and records and reporting system. Volume III. Reporting system forms and instructions--required.

    DOT National Transportation Integrated Search

    1977-01-10

    The purpose of the report is to present and document the detailed features of the uniform system of accounts and records and reporting system required by Section 15 of the Urban Mass Transportation Act of 1964, as amended. Volume 3 contains illustrat...

  5. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

    PubMed Central

    Lichtenegger, Felix S.; Rothe, Maurine; Schnorfeil, Frauke M.; Deiser, Katrin; Krupka, Christina; Augsberger, Christian; Schlüter, Miriam; Neitz, Julia; Subklewe, Marion

    2018-01-01

    Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not shown a clear clinical benefit so far. Therapeutic vaccination, particularly dendritic cell (DC) vaccination, is a strategy to induce T cell responses. Interaction of DCs and T cells is dependent on receptor–ligand interactions of various immune checkpoints. In this study, we analyzed the influence of blocking antibodies targeting programmed cell death protein 1 (PD-1), HVEM, CD244, TIM-3, and lymphocyte activation gene 3 (LAG-3) on the proliferation and cytokine secretion of T cells after stimulation with autologous TLR-matured DCs. In this context, we found that LAG-3 blockade resulted in superior T cell activation compared to inhibition of other pathways, including PD-1/PD-L1. This result was consistent across different methods to measure T cell stimulation (proliferation, IFN-γ secretion), various stimulatory antigens (viral and bacterial peptide pool, specific viral antigen, specific tumor antigen), and seen for both CD4+ and CD8+ T cells. Only under conditions with a weak antigenic stimulus, particularly when combining antigen presentation by peripheral blood mononuclear cells with low concentrations of peptides, we observed the highest T cell stimulation with dual blockade of LAG-3 and PD-1 blockade. We conclude that priming of novel immune responses can be strongly enhanced by blockade of LAG-3 or dual blockade of LAG-3 and PD-1, depending on the strength of the antigenic stimulus. PMID:29535740

  6. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

    PubMed

    Lichtenegger, Felix S; Rothe, Maurine; Schnorfeil, Frauke M; Deiser, Katrin; Krupka, Christina; Augsberger, Christian; Schlüter, Miriam; Neitz, Julia; Subklewe, Marion

    2018-01-01

    Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not shown a clear clinical benefit so far. Therapeutic vaccination, particularly dendritic cell (DC) vaccination, is a strategy to induce T cell responses. Interaction of DCs and T cells is dependent on receptor-ligand interactions of various immune checkpoints. In this study, we analyzed the influence of blocking antibodies targeting programmed cell death protein 1 (PD-1), HVEM, CD244, TIM-3, and lymphocyte activation gene 3 (LAG-3) on the proliferation and cytokine secretion of T cells after stimulation with autologous TLR-matured DCs. In this context, we found that LAG-3 blockade resulted in superior T cell activation compared to inhibition of other pathways, including PD-1/PD-L1. This result was consistent across different methods to measure T cell stimulation (proliferation, IFN-γ secretion), various stimulatory antigens (viral and bacterial peptide pool, specific viral antigen, specific tumor antigen), and seen for both CD4 + and CD8 + T cells. Only under conditions with a weak antigenic stimulus, particularly when combining antigen presentation by peripheral blood mononuclear cells with low concentrations of peptides, we observed the highest T cell stimulation with dual blockade of LAG-3 and PD-1 blockade. We conclude that priming of novel immune responses can be strongly enhanced by blockade of LAG-3 or dual blockade of LAG-3 and PD-1, depending on the strength of the antigenic stimulus.

  7. Hospitals' Internal Accountability

    PubMed Central

    Kraetschmer, Nancy; Jass, Janak; Woodman, Cheryl; Koo, Irene; Kromm, Seija K.; Deber, Raisa B.

    2014-01-01

    This study aimed to enhance understanding of the dimensions of accountability captured and not captured in acute care hospitals in Ontario, Canada. Based on an Ontario-wide survey and follow-up interviews with three acute care hospitals in the Greater Toronto Area, we found that the two dominant dimensions of hospital accountability being reported are financial and quality performance. These two dimensions drove both internal and external reporting. Hospitals' internal reports typically included performance measures that were required or mandated in external reports. Although respondents saw reporting as a valuable mechanism for hospitals and the health system to monitor and track progress against desired outcomes, multiple challenges with current reporting requirements were communicated, including the following: 58% of survey respondents indicated that performance-reporting resources were insufficient; manual data capture and performance reporting were prevalent, with the majority of hospitals lacking sophisticated tools or technology to effectively capture, analyze and report performance data; hospitals tended to focus on those processes and outcomes with high measurability; and 53% of respondents indicated that valuable cross-system accountability, performance measures or both were not captured by current reporting requirements. PMID:25305387

  8. Articulation Activity for Accounting Programs: Project Results and Descriptive Report. Final Report.

    ERIC Educational Resources Information Center

    Adams, Esther

    In response to the need for a basic articulated accounting curriculum providing for a smooth transition from the secondary to the postsecondary level, Blackhawk Technical Institute (BTI) conducted a project to develop a master list of accounting competencies as the basis of a core accounting curriculum; to determine competency standards; to…

  9. A Commentary on "Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum"

    ERIC Educational Resources Information Center

    Correa Ruiz, Carmen

    2013-01-01

    In this commentary, Correa Ruiz notes that from his analysis, Owen (2013) identified the essential elements to be included in a modern professional accounting curriculum, described how Association of Chartered Certified Accountants (ACCA) has embedded "Integrated Reporting" in its curriculum, and discussed future curriculum development,…

  10. Time-dependent Electron Acceleration in Blazar Transients: X-Ray Time Lags and Spectral Formation

    NASA Astrophysics Data System (ADS)

    Lewis, Tiffany R.; Becker, Peter A.; Finke, Justin D.

    2016-06-01

    Electromagnetic radiation from blazar jets often displays strong variability, extending from radio to γ-ray frequencies. In a few cases, this variability has been characterized using Fourier time lags, such as those detected in the X-rays from Mrk 421 using BeppoSAX. The lack of a theoretical framework to interpret the data has motivated us to develop a new model for the formation of the X-ray spectrum and the time lags in blazar jets based on a transport equation including terms describing stochastic Fermi acceleration, synchrotron losses, shock acceleration, adiabatic expansion, and spatial diffusion. We derive the exact solution for the Fourier transform of the electron distribution and use it to compute the Fourier transform of the synchrotron radiation spectrum and the associated X-ray time lags. The same theoretical framework is also used to compute the peak flare X-ray spectrum, assuming that a steady-state electron distribution is achieved during the peak of the flare. The model parameters are constrained by comparing the theoretical predictions with the observational data for Mrk 421. The resulting integrated model yields, for the first time, a complete first-principles physical explanation for both the formation of the observed time lags and the shape of the peak flare X-ray spectrum. It also yields direct estimates of the strength of the shock and the stochastic magnetohydrodynamical wave acceleration components in the Mrk 421 jet.

  11. Examining lag effects between industrial land development and regional economic changes: The Netherlands experience.

    PubMed

    Ustaoglu, Eda; Lavalle, Carlo

    2017-01-01

    In most empirical applications, forecasting models for the analysis of industrial land focus on the relationship between current values of economic parameters and industrial land use. This paper aims to test this assumption by focusing on the dynamic relationship between current and lagged values of the 'economic fundamentals' and industrial land development. Not much effort has yet been attributed to develop land forecasting models to predict the demand for industrial land except those applying static regressions or other statistical measures. In this research, we estimated a dynamic panel data model across 40 regions from 2000 to 2008 for the Netherlands to uncover the relationship between current and lagged values of economic parameters and industrial land development. Land-use regulations such as land zoning policies, and other land-use restrictions like natural protection areas, geographical limitations in the form of water bodies or sludge areas are expected to affect supply of land, which will in turn be reflected in industrial land market outcomes. Our results suggest that gross domestic product (GDP), industrial employment, gross value added (GVA), property price, and other parameters representing demand and supply conditions in the industrial market explain industrial land developments with high significance levels. It is also shown that contrary to the current values, lagged values of the economic parameters have more sound relationships with the industrial developments in the Netherlands. The findings suggest use of lags between selected economic parameters and industrial land use in land forecasting applications.

  12. TIME-DEPENDENT ELECTRON ACCELERATION IN BLAZAR TRANSIENTS: X-RAY TIME LAGS AND SPECTRAL FORMATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lewis, Tiffany R.; Becker, Peter A.; Finke, Justin D., E-mail: pbecker@gmu.edu, E-mail: tlewis13@gmu.edu, E-mail: justin.finke@nrl.navy.mil

    2016-06-20

    Electromagnetic radiation from blazar jets often displays strong variability, extending from radio to γ -ray frequencies. In a few cases, this variability has been characterized using Fourier time lags, such as those detected in the X-rays from Mrk 421 using Beppo SAX. The lack of a theoretical framework to interpret the data has motivated us to develop a new model for the formation of the X-ray spectrum and the time lags in blazar jets based on a transport equation including terms describing stochastic Fermi acceleration, synchrotron losses, shock acceleration, adiabatic expansion, and spatial diffusion. We derive the exact solution formore » the Fourier transform of the electron distribution and use it to compute the Fourier transform of the synchrotron radiation spectrum and the associated X-ray time lags. The same theoretical framework is also used to compute the peak flare X-ray spectrum, assuming that a steady-state electron distribution is achieved during the peak of the flare. The model parameters are constrained by comparing the theoretical predictions with the observational data for Mrk 421. The resulting integrated model yields, for the first time, a complete first-principles physical explanation for both the formation of the observed time lags and the shape of the peak flare X-ray spectrum. It also yields direct estimates of the strength of the shock and the stochastic magnetohydrodynamical wave acceleration components in the Mrk 421 jet.« less

  13. Examining lag effects between industrial land development and regional economic changes: The Netherlands experience

    PubMed Central

    Ustaoglu, Eda; Lavalle, Carlo

    2017-01-01

    In most empirical applications, forecasting models for the analysis of industrial land focus on the relationship between current values of economic parameters and industrial land use. This paper aims to test this assumption by focusing on the dynamic relationship between current and lagged values of the ‘economic fundamentals’ and industrial land development. Not much effort has yet been attributed to develop land forecasting models to predict the demand for industrial land except those applying static regressions or other statistical measures. In this research, we estimated a dynamic panel data model across 40 regions from 2000 to 2008 for the Netherlands to uncover the relationship between current and lagged values of economic parameters and industrial land development. Land-use regulations such as land zoning policies, and other land-use restrictions like natural protection areas, geographical limitations in the form of water bodies or sludge areas are expected to affect supply of land, which will in turn be reflected in industrial land market outcomes. Our results suggest that gross domestic product (GDP), industrial employment, gross value added (GVA), property price, and other parameters representing demand and supply conditions in the industrial market explain industrial land developments with high significance levels. It is also shown that contrary to the current values, lagged values of the economic parameters have more sound relationships with the industrial developments in the Netherlands. The findings suggest use of lags between selected economic parameters and industrial land use in land forecasting applications. PMID:28877204

  14. Financial Reporting for the Defense Logistics Agency - General Funds at Defense Finance and Accounting Service Columbus

    DTIC Science & Technology

    2002-01-18

    the largest net abnormal balances, totaling $20.9 million (finding A). We audited the financial reporting procedures that Defense Finance and Accounting Service Columbus used to report on Treasury Index 97 funds.

  15. Excellence and Accountability. Report of the Governor's Task Force on Higher Education Reform.

    ERIC Educational Resources Information Center

    New Mexico State Commission on Postsecondary Education, Santa Fe.

    A task force report recommends ways to promote educational reform in higher education in New Mexico. Forty recommendations address the following areas: institutional missions, academic excellence and accountability, community colleges, student financial aid, affirmative action, economic development, capital outlay, and funding issues. Specific…

  16. Report: EPA Managers Did Not Hold Supervisors and Project Officers Accountable for Grants Management

    EPA Pesticide Factsheets

    Report #2005-P-00027, September 27, 2005. Managers did not sufficiently hold supervisors and project officers accountable for grants management because there is no process to measure most grants management activity.

  17. 78 FR 52984 - Report on Countries That Are Candidates for Millennium Challenge Account Eligibility in Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Millennium Challenge Account Eligibility in Fiscal Year 2014 and Countries That Would Be Candidates But For... during FY 2014. The report is set forth in full below. Dated: August 22, 2013. Melvin F. Williams, Jr... That Are Candidates for Millennium Challenge Account Eligibility for Fiscal Year 2014 and Countries...

  18. Special Report on the "Department of Energy's Efforts to Meet Accountability and Performance Reporting Objectives of the American Recovery and Reinvestment Act"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    The purpose of the American Recovery and Reinvestment Act of 2009 (Recovery Act) was to jumpstart the U.S. economy, create or save millions of jobs, spur technological advances in health and science, and invest in the Nation's energy future. The Department of Energy will receive an unprecedented $38 billion in Recovery Act funding to support a variety of science, energy, and environmental initiatives. The Recovery Act requires transparency and accountability over these funds. To this end, the Office of Management and Budget (OMB) issued guidance requiring the Department to compile and report a wide variety of funding, accounting, and performancemore » information. The Department plans to leverage existing information systems to develop accounting and performance information that will be used by program managers and ultimately reported to Recovery.gov, the government-wide source of Recovery Act information, and to OMB. The Department's iManage iPortal, a system that aggregates information from a number of corporate systems, will serve as the main reporting gateway for accounting information. In addition, the Department plans to implement a methodology or system that will permit it to monitor information reported directly to OMB by prime funding recipients. Furthermore, performance measures or metrics that outline expected outcomes are being developed, with results ultimately to be reported in a recently developed Department-wide system. Because of the significance of funds provided and their importance to strengthening the Nation's economy, we initiated this review to determine whether the Department had taken the steps necessary to ensure that Recovery Act funds can be appropriately tracked and are transparent to the public, and whether the benefits of the expenditures can be properly measured and reported clearly, accurately, and in a timely manner. Although not yet fully mature, we found that the Department's efforts to develop, refine, and apply the control

  19. Rapid increases and time-lagged declines in amphibian occupancy after wildfire.

    PubMed

    Hossack, Blake R; Lowe, Winsor H; Corn, Paul Stephen

    2013-02-01

    Climate change is expected to increase the frequency and severity of drought and wildfire. Aquatic and moisture-sensitive species, such as amphibians, may be particularly vulnerable to these modified disturbance regimes because large wildfires often occur during extended droughts and thus may compound environmental threats. However, understanding of the effects of wildfires on amphibians in forests with long fire-return intervals is limited. Numerous stand-replacing wildfires have occurred since 1988 in Glacier National Park (Montana, U.S.A.), where we have conducted long-term monitoring of amphibians. We measured responses of 3 amphibian species to fires of different sizes, severity, and age in a small geographic area with uniform management. We used data from wetlands associated with 6 wildfires that burned between 1988 and 2003 to evaluate whether burn extent and severity and interactions between wildfire and wetland isolation affected the distribution of breeding populations. We measured responses with models that accounted for imperfect detection to estimate occupancy during prefire (0-4 years) and different postfire recovery periods. For the long-toed salamander (Ambystoma macrodactylum) and Columbia spotted frog (Rana luteiventris), occupancy was not affected for 6 years after wildfire. But 7-21 years after wildfire, occupancy for both species decreased ≥ 25% in areas where >50% of the forest within 500 m of wetlands burned. In contrast, occupancy of the boreal toad (Anaxyrus boreas) tripled in the 3 years after low-elevation forests burned. This increase in occupancy was followed by a gradual decline. Our results show that accounting for magnitude of change and time lags is critical to understanding population dynamics of amphibians after large disturbances. Our results also inform understanding of the potential threat of increases in wildfire frequency or severity to amphibians in the region. ©2012 Society for Conservation Biology.

  20. Rapid increases and time-lagged declines in amphibian occupancy after wildfire

    USGS Publications Warehouse

    Hossack, Blake R.; Lowe, Winsor H.; Corn, Paul Stephen

    2013-01-01

    Climate change is expected to increase the frequency and severity of drought and wildfire. Aquatic and moisture-sensitive species, such as amphibians, may be particularly vulnerable to these modified disturbance regimes because large wildfires often occur during extended droughts and thus may compound environmental threats. However, understanding of the effects of wildfires on amphibians in forests with long fire-return intervals is limited. Numerous stand-replacing wildfires have occurred since 1988 in Glacier National Park (Montana, U.S.A.), where we have conducted long-term monitoring of amphibians. We measured responses of 3 amphibian species to fires of different sizes, severity, and age in a small geographic area with uniform management. We used data from wetlands associated with 6 wildfires that burned between 1988 and 2003 to evaluate whether burn extent and severity and interactions between wildfire and wetland isolation affected the distribution of breeding populations. We measured responses with models that accounted for imperfect detection to estimate occupancy during prefire (0-4 years) and different postfire recovery periods. For the long-toed salamander (Ambystoma macrodactylum) and Columbia spotted frog (Rana luteiventris), occupancy was not affected for 6 years after wildfire. But 7-21 years after wildfire, occupancy for both species decreased ≥ 25% in areas where >50% of the forest within 500 m of wetlands burned. In contrast, occupancy of the boreal toad (Anaxyrus boreas) tripled in the 3 years after low-elevation forests burned. This increase in occupancy was followed by a gradual decline. Our results show that accounting for magnitude of change and time lags is critical to understanding population dynamics of amphibians after large disturbances. Our results also inform understanding of the potential threat of increases in wildfire frequency or severity to amphibians in the region.

  1. Using lagged dependence to identify (de)coupled surface and subsurface soil moisture values

    NASA Astrophysics Data System (ADS)

    Carranza, Coleen D. U.; van der Ploeg, Martine J.; Torfs, Paul J. J. F.

    2018-04-01

    Recent advances in radar remote sensing popularized the mapping of surface soil moisture at different spatial scales. Surface soil moisture measurements are used in combination with hydrological models to determine subsurface soil moisture values. However, variability of soil moisture across the soil column is important for estimating depth-integrated values, as decoupling between surface and subsurface can occur. In this study, we employ new methods to investigate the occurrence of (de)coupling between surface and subsurface soil moisture. Using time series datasets, lagged dependence was incorporated in assessing (de)coupling with the idea that surface soil moisture conditions will be reflected at the subsurface after a certain delay. The main approach involves the application of a distributed-lag nonlinear model (DLNM) to simultaneously represent both the functional relation and the lag structure in the time series. The results of an exploratory analysis using residuals from a fitted loess function serve as a posteriori information to determine (de)coupled values. Both methods allow for a range of (de)coupled soil moisture values to be quantified. Results provide new insights into the decoupled range as its occurrence among the sites investigated is not limited to dry conditions.

  2. Investigation of Spectral Lag and Epeak as Joint Luminosity Indicators in GRBs

    NASA Technical Reports Server (NTRS)

    White, Nicholas E. (Technical Monitor); Norris, Jay P.

    2003-01-01

    Models for gamma-ray bursts which invoke jetted, colliding shells would appear to have at least two determinants for luminosity, e.g., observer viewing angle and Lorentz factor, or possibly shell mass. The latter two internal physical parameters may vary from pulse to pulse within a burst, and such variation might be reflected in evolution of observables such as spectral lag and peak in the spectral energy distribution. We analyze bright BATSE bursts using the 16-channel medium energy resolution (MER) data, with time resolutions of 16 and 64 ms, measuring spectral lags and peak energies for significant pulse structures within a burst, identified using a Bayesian block algorithm. We then explore correlations between the measured parameters and total flux for the individual pulse structures.

  3. The Evolution of the Phase Lags Associated with the Type-C Quasi-periodic Oscillation in GX 339-4 during the 2006/2007 Outburst

    NASA Astrophysics Data System (ADS)

    Zhang, Liang; Wang, Yanan; Méndez, Mariano; Chen, Li; Qu, Jinlu; Altamirano, Diego; Belloni, Tomaso

    2017-08-01

    We present the evolution of the phase lags associated with the type-C QPO in GX 339-4 during the rising phase of the 2006/2007 outburst. We find that the phase lags at the QPO frequency are always positive (hard) and show very different behavior between QPOs with frequencies below and above ˜1.7 Hz: when the QPO frequency is below ˜1.7 Hz, the phase lags increase both with QPO frequency and energy, while when the QPO frequency is above ˜1.7 Hz, the phase lags remain more or less constant. When the QPO frequency is higher than ˜1.7 Hz, a broad feature is always present in the lag-energy spectra at around 6.5 keV, suggesting that the reflection component may have a significant contribution to the phase lags. Below ˜1.7 Hz, the QPO rms first decreases with energy and then turns to almost flat, while above ˜1.7 Hz, the QPO rms increases with energy. During the transition from the low-hard state to the hard-intermediate state, the second harmonic and subharmonic of this QPO appear in the power density spectra. The second-harmonic and subharmonic phase lags show very similar evolutions for their centroid frequencies. However, the energy dependence of the second-harmonic and subharmonic phase lags are quite different. Our results suggest that, at different phases of the outburst, different mechanisms may be responsible for the phase lags of the QPO. We briefly discuss the possible scenarios for producing the lags.

  4. An experimental investigation of the flap-lag-torsion aeroelastic stability of a small-scale hingeless helicopter rotor in hover

    NASA Technical Reports Server (NTRS)

    Sharpe, David L.

    1986-01-01

    A small scale, 1.92 m diam, torsionally soft, hingeless helicopter rotor was investigated in hover to determine isolated rotor stability characteristics. The two-bladed, untwisted rotor was tested on a rigid test stand at tip speeds up to 101 m/sec. The rotor mode of interest is the lightly damped lead-lag mode. The dimensionless lead-lag frequency of the mode is approximately 1.5 at the highest tip speed. The hub was designed to allow variation in precone, blade droop, pitch control stiffness, and blade pitch angle. Measurements of modal frequency and damping were obtained for several combinations of these hub parameters at several values of rotor speed. Steady blade bending moments were also measured. The lead-lag damping measurements were found to agree well with theoretical predictions for low values of blade pitch angle. The test data confirmed the predicted effects of precone, droop, and pitch control stiffness parameters on lead-lag damping. The correlation between theory and experiment was found to be poor for the mid-to-high range of pitch angles where the theory substantially overpredicted the experimental lead-lag damping. The poor correlation in the mid-to-high blade pitch angle range is attributed to low Reynolds number nonlinear aerodynamics effects not included in the theory. The experimental results also revealed an asymmetry in lead-lag damping between positive and negative thrust conditions.

  5. Lag periods during the self-assembly of {Mo(72)Fe(30)} macroions: connection to the virus capsid formation process.

    PubMed

    Zhang, Jie; Li, Dong; Liu, Guang; Glover, Kerney Jebrell; Liu, Tianbo

    2009-10-28

    The kinetic properties of the self-assembly of hydrophilic Keplerate-type polyoxometalate (POM) {Mo(72)Fe(30)} macroanions into single-layer, vesicle-like blackberry structures in solutions were monitored by the static and dynamic laser light scattering techniques. In the presence of additional electrolytes, an obvious lag period at the initial stage of self-assembly was observed, followed by a fast increase of the scattered intensity. The whole kinetic curve is sigmoidal with a lag phase. A two-step nucleation-growth mechanism is proposed to explain this lag phase: the {Mo(72)Fe(30)} macroanions slowly associate into oligomers (mostly dimers), which are the thermodynamically unfavorable intermediates, at the initial stage; once the oligomers reach a critical concentration, the blackberry formation process is accelerated. Analytical ultracentrifugation (AUC) was used to confirm the oligomeric state in {Mo(72)Fe(30)} solution during the lag period. The length of the lag period is dependent on temperature, ionic strength, and the valent states of the additional salts, as well as the solvent content. The kinetics (including the lag period) of the blackberry formation of the {Mo(72)Fe(30)} macroanions show similarities to the self-assembly of virus capsid proteins (which are also soluble macroions) into spherical capsid shells, suggesting possible connections between the self-assembly behaviors of inorganic species and biological macromolecules.

  6. 14 CFR 01 - Authority Under Which Accounting and Reporting Rules and Regulations are Prescribed and Administered

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Authority Under Which Accounting and... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 01 Authority... shall have authority under the orders of the Board to inspect and examine any and all such lands...

  7. 29 CFR 2520.104-46 - Waiver of examination and report of an independent qualified public accountant for employee...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... qualified public accountant for employee benefit plans with fewer than 100 participants. 2520.104-46 Section... Requirements § 2520.104-46 Waiver of examination and report of an independent qualified public accountant for... public accountant to conduct an examination of the financial statements of the plan; (2) Include within...

  8. 29 CFR 2520.104-46 - Waiver of examination and report of an independent qualified public accountant for employee...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... qualified public accountant for employee benefit plans with fewer than 100 participants. 2520.104-46 Section... Requirements § 2520.104-46 Waiver of examination and report of an independent qualified public accountant for... public accountant to conduct an examination of the financial statements of the plan; (2) Include within...

  9. 29 CFR 2520.104-46 - Waiver of examination and report of an independent qualified public accountant for employee...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... qualified public accountant for employee benefit plans with fewer than 100 participants. 2520.104-46 Section... Requirements § 2520.104-46 Waiver of examination and report of an independent qualified public accountant for... public accountant to conduct an examination of the financial statements of the plan; (2) Include within...

  10. 29 CFR 2520.104-46 - Waiver of examination and report of an independent qualified public accountant for employee...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... qualified public accountant for employee benefit plans with fewer than 100 participants. 2520.104-46 Section... Requirements § 2520.104-46 Waiver of examination and report of an independent qualified public accountant for... public accountant to conduct an examination of the financial statements of the plan; (2) Include within...

  11. 29 CFR 2520.104-46 - Waiver of examination and report of an independent qualified public accountant for employee...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... qualified public accountant for employee benefit plans with fewer than 100 participants. 2520.104-46 Section... Requirements § 2520.104-46 Waiver of examination and report of an independent qualified public accountant for... public accountant to conduct an examination of the financial statements of the plan; (2) Include within...

  12. A longer vernal window: the role of winter coldness and snowpack in driving spring transitions and lags.

    PubMed

    Contosta, Alexandra R; Adolph, Alden; Burchsted, Denise; Burakowski, Elizabeth; Green, Mark; Guerra, David; Albert, Mary; Dibb, Jack; Martin, Mary; McDowell, William H; Routhier, Michael; Wake, Cameron; Whitaker, Rachel; Wollheim, Wilfred

    2017-04-01

    Climate change is altering the timing and duration of the vernal window, a period that marks the end of winter and the start of the growing season when rapid transitions in ecosystem energy, water, nutrient, and carbon dynamics take place. Research on this period typically captures only a portion of the ecosystem in transition and focuses largely on the dates by which the system wakes up. Previous work has not addressed lags between transitions that represent delays in energy, water, nutrient, and carbon flows. The objectives of this study were to establish the sequence of physical and biogeochemical transitions and lags during the vernal window period and to understand how climate change may alter them. We synthesized observations from a statewide sensor network in New Hampshire, USA, that concurrently monitored climate, snow, soils, and streams over a three-year period and supplemented these observations with climate reanalysis data, snow data assimilation model output, and satellite spectral data. We found that some of the transitions that occurred within the vernal window were sequential, with air temperatures warming prior to snow melt, which preceded forest canopy closure. Other transitions were simultaneous with one another and had zero-length lags, such as snowpack disappearance, rapid soil warming, and peak stream discharge. We modeled lags as a function of both winter coldness and snow depth, both of which are expected to decline with climate change. Warmer winters with less snow resulted in longer lags and a more protracted vernal window. This lengthening of individual lags and of the entire vernal window carries important consequences for the thermodynamics and biogeochemistry of ecosystems, both during the winter-to-spring transition and throughout the rest of the year. © 2016 The Authors Global Change Biology Published by John Wiley & Sons Ltd.

  13. Simulation and measurement of total ionizing dose radiation induced image lag increase in pinned photodiode CMOS image sensors

    NASA Astrophysics Data System (ADS)

    Liu, Jing; Chen, Wei; Wang, Zujun; Xue, Yuanyuan; Yao, Zhibin; He, Baoping; Ma, Wuying; Jin, Junshan; Sheng, Jiangkun; Dong, Guantao

    2017-06-01

    This paper presents an investigation of total ionizing dose (TID) induced image lag sources in pinned photodiodes (PPD) CMOS image sensors based on radiation experiments and TCAD simulation. The radiation experiments have been carried out at the Cobalt -60 gamma-ray source. The experimental results show the image lag degradation is more and more serious with increasing TID. Combining with the TCAD simulation results, we can confirm that the junction of PPD and transfer gate (TG) is an important region forming image lag during irradiation. These simulations demonstrate that TID can generate a potential pocket leading to incomplete transfer.

  14. Accelerating recovery from jet lag: prediction from a multi-oscillator model and its experimental confirmation in model animals

    NASA Astrophysics Data System (ADS)

    Kori, Hiroshi; Yamaguchi, Yoshiaki; Okamura, Hitoshi

    2017-04-01

    The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one’s internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such misalignments are accompanied by sleep disturbances and gastrointestinal distress. Repeated exposure to jet lag and rotating shift work increases the risk of lifestyle-related diseases, such as cardiovascular complaints and metabolic insufficiencies. However, the mechanism behind the disruption of one’s internal clock is not well understood. In this paper, we therefore present a new theoretical concept called “jet lag separatrix” to understand circadian clock disruption and slow recovery from jet lag based on the mathematical model describing the hierarchical structure of the circadian clock. To demonstrate the utility of our theoretical study, we applied it to predict that re-entrainment via a two-step jet lag in which a four-hour shift of the light-dark cycle is given in the span of two successive days requires fewer days than when given as a single eight-hour shift. We experimentally verified the feasibility of our theory in C57BL/6 strain mice, with results indicating that this pre-exposure of jet lag is indeed beneficial.

  15. A flight-dynamic helicopter mathematical model with a single flap-lag-torsion main rotor

    NASA Technical Reports Server (NTRS)

    Takahashi, Marc D.

    1990-01-01

    A mathematical model of a helicopter system with a single main rotor that includes rigid, hinge-restrained rotor blades with flap, lag, and torsion degrees of freedom is described. The model allows several hinge sequences and two offsets in the hinges. Quasi-steady Greenberg theory is used to calculate the blade-section aerodynamic forces, and inflow effects are accounted for by using three-state nonlinear dynamic inflow model. The motion of the rigid fuselage is defined by six degrees of freedom, and an optional rotor rpm degree of freedom is available. Empennage surfaces and the tail rotor are modeled, and the effect of main-rotor downwash on these elements is included. Model trim linearization, and time-integration operations are described and can be applied to a subset of the model in the rotating or nonrotating coordinate frame. A preliminary validation of the model is made by comparing its results with those of other analytical and experimental studies. This publication presents the results of research compiled in November 1989.

  16. A Harmonious Accounting Duo?

    ERIC Educational Resources Information Center

    Schapperle, Robert F.; Hardiman, Patrick F.

    1992-01-01

    Accountants have urged "harmonization" of standards between the Governmental Accounting Standards Board and the Financial Accounting Standards Board, recommending similar reporting of like transactions. However, varying display of similar accounting events does not necessarily indicate disharmony. The potential for problems because of…

  17. Environmental reporting and accounting in Australia: progress, prospects and research priorities.

    PubMed

    van Dijk, Albert; Mount, Richard; Gibbons, Philip; Vardon, Michael; Canadell, Pep

    2014-03-01

    Despite strong demand for information to support the sustainable use of Australia's natural resources and conserve environmental values and despite considerable effort and investment, nation-wide environmental data collection and analysis remains a substantially unmet challenge. We review progress in producing national environmental reports and accounts, identify challenges and opportunities, and analyse the potential role of research in addressing these. Australia's low and concentrated population density and the short history since European settlement contribute to the lack of environmental data. There are additional factors: highly diverse data requirements and standards, disagreement on information priorities, poorly measurable management objectives, lack of coordination, over-reliance on researchers and businesses for data collection, lack of business engagement, and short-term, project-based activities. New opportunities have arisen to overcome some of these challenges: enhanced monitoring networks, standardisation, data management and modelling, greater commitment to share and integrate data, community monitoring, increasing acceptance of environmental and sustainability indicators, and progress in environmental accounting practices. Successes in generating climate, water and greenhouse gas information appear to be attributable to an unambiguous data requirement, considerable investment, and legislative instruments that enhance data sharing and create a clearly defined role for operational agencies. Based on the analysis presented, we suggest six priorities for research: (1) common definitions and standards for information that address management objectives, (2) ecological measures that are scalable from local to national level, (3) promotion of long-term data collection and reporting by researchers, (4) efficient satellite and sensor network technologies and data analysis methods, (5) environmental modelling approaches that can reconcile multiple data

  18. Individual cell lag time distributions of Cronobacter (Enterobacter sakazakii) and impact of pooling samples on its detection in powdered infant formula.

    PubMed

    Miled, Rabeb Bennour; Guillier, Laurent; Neves, Sandra; Augustin, Jean-Christophe; Colin, Pierre; Besse, Nathalie Gnanou

    2011-06-01

    Cells of six strains of Cronobacter were subjected to dry stress and stored for 2.5 months at ambient temperature. The individual cell lag time distributions of recovered cells were characterized at 25 °C and 37 °C in non-selective broth. The individual cell lag times were deduced from the times taken by cultures from individual cells to reach an optical density threshold. In parallel, growth curves for each strain at high contamination levels were determined in the same growth conditions. In general, the extreme value type II distribution with a shape parameter fixed to 5 (EVIIb) was the most effective at describing the 12 observed distributions of individual cell lag times. Recently, a model for characterizing individual cell lag time distribution from population growth parameters was developed for other food-borne pathogenic bacteria such as Listeria monocytogenes. We confirmed this model's applicability to Cronobacter by comparing the mean and the standard deviation of individual cell lag times to populational lag times observed with high initial concentration experiments. We also validated the model in realistic conditions by studying growth in powdered infant formula decimally diluted in Buffered Peptone Water, which represents the first enrichment step of the standard detection method for Cronobacter. Individual lag times and the pooling of samples significantly affect detection performances. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Logic of Accounting: The Case of Reporting Previous Options in Norwegian Activation Encounters

    ERIC Educational Resources Information Center

    Solberg, Janne

    2017-01-01

    The article deals with the enactment of client resistance in Norwegian vocational rehabilitation encounters. More specific, a practice here called "reporting previous options" is analyzed by using the resources of ethnomethodological conversation analysis (CA) in five instances as doing some sort of accounting. In response to the…

  20. Relationships among abilities in elderly adults: a time lag analysis.

    PubMed

    Hayslip, B; Brookshire, R G

    1985-11-01

    Previous research has suggested that relationships among primary abilities said to measure crystallized (Gc) and fluid (Gf) intelligences remain the same across cohorts if age is held constant, despite generational changes in the levels of abilities. The present study assessed differences in relationship among several components of Gf/Gc in two independent samples of elderly adults, tested in 1975 and 1979 by the same investigator. The 1975 sample consisted of 54 elderly adults aged 59 to 76 years (M = 67.7); the 1979 sample of 50 elderly adults was aged 55 to 82 (M = 69.4). Time-lagged differences in relationships among abilities measuring Gf and Gc (induction, figural relations, and verbal comprehension) were investigated using confirmatory factor analytic procedures. Although a two factor (Gf, Gc) model was common to both the 1975 and 1979 samples, significant differences in unique variances were observed across samples. Some, albeit weaker, evidence was found suggesting time-lagged differences in factor covariances. These data, for the most part, support previous research with younger individuals, suggesting consistency in factor structure across time and cohort.

  1. Report on Fiscal Year 1991 financial statement audit of the Low-Level Radioactive Waste Surcharge Escrow Account (CR-FC-92-1)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-06-26

    The attached audit report on the subject account presents the opinion of the independent certified public accounts on financial statements as of September 30, 1991. In their opinion, the Surcharge Account statements are fairly presented in all material respects in accordance with generally accepted accounting principles. Also attached are reports on the internal control structure and compliance with laws and regulations, ass well as management`s letter on addressing needed improvements.

  2. Report on Fiscal Year 1991 financial statement audit of the Low-Level Radioactive Waste Surcharge Escrow Account (CR-FC-92-1)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-06-26

    The attached audit report on the subject account presents the opinion of the independent certified public accounts on financial statements as of September 30, 1991. In their opinion, the Surcharge Account statements are fairly presented in all material respects in accordance with generally accepted accounting principles. Also attached are reports on the internal control structure and compliance with laws and regulations, ass well as management's letter on addressing needed improvements.

  3. Dynamic light scattering: A fast and reliable method to analyze bacterial growth during the lag phase.

    PubMed

    Vargas, Susana; Millán-Chiu, Blanca E; Arvizu-Medrano, Sofía M; Loske, Achim M; Rodríguez, Rogelio

    2017-06-01

    A comparison between plate counting (PC) and dynamic light scattering (DLS) is reported. PC is the standard technique to determine bacterial population as a function of time; however, this method has drawbacks, such as the cumbersome preparation and handling of samples, as well as the long time required to obtain results. Alternative methods based on optical density are faster, but do not distinguish viable from non-viable cells. These inconveniences are overcome by using DLS. Two different bacteria strains were considered: Escherichia coli and Staphylococcus aureus. DLS was performed at two different illuminating conditions: continuous and intermittent. By the increment of particle size as a function of time, it was possible to observe cell division and the formation of aggregates containing very few bacteria. The scattered intensity profiles showed the lag phase and the transition to the exponential phase of growth, providing a quantity proportional to viable bacteria concentration. The results revealed a clear and linear correlation in both lag and exponential phase, between the Log 10 (colony-forming units/mL) from PC and the Log 10 of the scattered intensity I s from DLS. These correlations provide a good support to use DLS as an alternative technique to determine bacterial population. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. The effect of rising vs. falling glucose level on amperometric glucose sensor lag and accuracy in Type 1 diabetes.

    PubMed

    Ward, W K; Engle, J M; Branigan, D; El Youssef, J; Massoud, R G; Castle, J R

    2012-08-01

    Because declining glucose levels should be detected quickly in persons with Type 1 diabetes, a lag between blood glucose and subcutaneous sensor glucose can be problematic. It is unclear whether the magnitude of sensor lag is lower during falling glucose than during rising glucose. Initially, we analysed 95 data segments during which glucose changed and during which very frequent reference blood glucose monitoring was performed. However, to minimize confounding effects of noise and calibration error, we excluded data segments in which there was substantial sensor error. After these exclusions, and combination of data from duplicate sensors, there were 72 analysable data segments (36 for rising glucose, 36 for falling). We measured lag in two ways: (1) the time delay at the vertical mid-point of the glucose change (regression delay); and (2) determination of the optimal time shift required to minimize the difference between glucose sensor signals and blood glucose values drawn concurrently. Using the regression delay method, the mean sensor lag for rising vs. falling glucose segments was 8.9 min (95%CI 6.1-11.6) vs. 1.5 min (95%CI -2.6 to 5.5, P<0.005). Using the time shift optimization method, results were similar, with a lag that was higher for rising than for falling segments [8.3 (95%CI 5.8-10.7) vs. 1.5 min (95% CI -2.2 to 5.2), P<0.001]. Commensurate with the lag results, sensor accuracy was greater during falling than during rising glucose segments. In Type 1 diabetes, when noise and calibration error are minimized to reduce effects that confound delay measurement, subcutaneous glucose sensors demonstrate a shorter lag duration and greater accuracy when glucose is falling than when rising. © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.

  5. [Time lag effect between poplar' s sap flow velocity and microclimate factors in agroforestry system in West Liaoning Province].

    PubMed

    Di, Sun; Guan, De-xin; Yuan, Feng-hui; Wang, An-zhi; Wu, Jia-bing

    2010-11-01

    By using Granier's thermal dissipation probe, the sap flow velocity of the poplars in agroforestry system in west Liaoning was continuously measured, and the microclimate factors were measured synchronously. Dislocation contrast method was applied to analyze the sap flow velocity and corresponding air temperature, air humidity, net radiation, and vapor pressure deficit to discuss the time lag effect between poplar' s sap flow velocity and microclimate factors on sunny days. It was found that the poplar's sap flow velocity advanced of air temperature, air humidity, and vapor pressure deficit, and lagged behind net radiation. The sap flow velocity in June, July, August, and September was advanced of 70, 30, 50, and 90 min to air temperature, of 80, 30, 40, and 90 min to air humidity, and of 90, 50, 70, and 120 min to vapor pressure deficit, but lagged behind 10, 10, 40, and 40 min to net radiation, respectively. The time lag time of net radiation was shorter than that of air temperature, air humidity, and vapor pressure. The regression analysis showed that in the cases the time lag effect was contained and not, the determination coefficients between comprehensive microclimate factor and poplar's sap flow velocity were 0.903 and 0.855, respectively, indicating that when the time lag effect was contained, the determination coefficient was ascended by 2.04%, and thus, the simulation accuracy of poplar's sap flow velocity was improved.

  6. Investigating the Twenty Year Lag in the Vocational Rehabilitation Process.

    ERIC Educational Resources Information Center

    Lowitt, Julian

    In the rehabilitation workshop there is insufficient attention to job development oriented to the current and future needs of industry. Many types of work which were done in vocational workshops in contract from industrial firms are now done by automation. Semiskilled labor is thus in diminished demand. There is a twenty year lag in the industrial…

  7. Heat conduction errors and time lag in cryogenic thermometer installations

    NASA Technical Reports Server (NTRS)

    Warshawsky, I.

    1973-01-01

    Installation practices are recommended that will increase rate of heat exchange between the thermometric sensing element and the cryogenic fluid and that will reduce the rate of undesired heat transfer to higher-temperature objects. Formulas and numerical data are given that help to estimate the magnitude of heat-conduction errors and of time lag in response.

  8. Analysis of inadvertent microprocessor lag time on eddy covariance results

    Treesearch

    Karl Zeller; Gary Zimmerman; Ted Hehn; Evgeny Donev; Diane Denny; Jeff Welker

    2001-01-01

    Researchers using the eddy covariance approach to measuring trace gas fluxes are often hoping to measure carbon dioxide and energy fluxes for ecosystem intercomparisons. This paper demonstrates a systematic microprocessor- caused lag of 20.1 to 20.2 s in a commercial sonic anemometer-analog-to-digital datapacker system operated at 10 Hz. The result of the inadvertent...

  9. Analyzing the Operation of Performance-Based Accountability Systems for Public Services. Technical Report

    ERIC Educational Resources Information Center

    Camm, Frank; Stecher, Brian M.

    2010-01-01

    Empirical evidence of the effects of performance-based public management is scarce. This report describes a framework used to organize available empirical information on one form of performance-based management, a performance-based accountability system (PBAS). Such a system identifies individuals or organizations that must change their behavior…

  10. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What type of reporting is required to ensure accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY...

  11. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What type of reporting is required to ensure accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY...

  12. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What type of reporting is required to ensure accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY...

  13. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What type of reporting is required to ensure accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY...

  14. Self-Study and Evaluation Guide; Section C-2; Financial Accounting and Service Reporting.

    ERIC Educational Resources Information Center

    National Accreditation Council for Agencies Serving the Blind and Visually Handicapped, New York, NY.

    In determining standards to judge an agency's performance in meeting its responsibilities to the public, two fundamental factors must be taken into consideration: (1) standards for financial accounting and service reporting must be formulated in the knowledge that variations among agencies will necessarily give rise to variations in applicability…

  15. Coupled lagged ensemble weather- and river runoff prediction in complex Alpine terrain

    NASA Astrophysics Data System (ADS)

    Smiatek, Gerhard; Kunstmann, Harald; Werhahn, Johannes

    2013-04-01

    It is still a challenge to predict fast reacting streamflow precipitation response in Alpine terrain. Civil protection measures require flood prediction in 24 - 48 lead time. This holds particularly true for the Ammer River region which was affected by century floods in 1999, 2003 and 2005. Since 2005 a coupled NWP/Hydrology model system is operated in simulating and predicting the Ammer River discharges. The Ammer River catchment is located in the Bavarian Ammergau Alps and alpine forelands, Germany. With elevations reaching 2185 m and annual mean precipitation between 1100 and 2000 mm it represents very demanding test ground for a river runoff prediction system. The one way coupled system utilizes a lagged ensemble prediction system (EPS) taking into account combination of recent and previous NWP forecasts. The major components of the system are the MM5 NWP model run at 3.5 km resolution and initialized twice a day, the hydrology model WaSiM-ETH run at 100 m resolution and Perl object environment (POE) implementing the networking and the system operation. Results obtained in the years 2005-2012 reveal that river runoff simulations depict already high correlation (NSC in range 0.53 and 0.95) with observed runoff in retrospective runs with monitored meteorology data, but suffer from errors in quantitative precipitation forecast (QPF) from the employed numerical weather prediction model. We evaluate the NWP model accuracy, especially the precipitation intensity, frequency and location and put a focus on the performance gain of bias adjustment procedures. We show how this enhanced QFP data help to reduce the uncertainty in the discharge prediction. In addition to the HND (Hochwassernachrichtendienst, Bayern) observations TERENO Longterm Observatory hydrometeorological observation data are available since 2011. They are used to evaluate the NWP performance and setup of a bias correction procedure based on ensemble postprocessing applying Bayesian (BMA) model averaging

  16. Technical Note: Intrafractional changes in time lag relationship between anterior-posterior external and superior-inferior internal motion signals in abdominal tumor sites.

    PubMed

    Regmi, Rajesh; Lovelock, D Michael; Zhang, Pengpeng; Pham, Hai; Xiong, Jianping; Yorke, Ellen D; Goodman, Karyn A; Wu, Abraham J; Mageras, Gig S

    2015-06-01

    To investigate constancy, within a treatment session, of the time lag relationship between implanted markers in abdominal tumors and an external motion surrogate. Six gastroesophageal junction and three pancreatic cancer patients (IRB-approved protocol) received two cone-beam CTs (CBCT), one before and one after treatment. Time between scans was less than 30 min. Each patient had at least one implanted fiducial marker near the tumor. In all scans, abdominal displacement (Varian RPM) was recorded as the external motion signal. Purpose-built software tracked fiducials, representing internal signal, in CBCT projection images. Time lag between superior-inferior (SI) internal and anterior-posterior external signals was found by maximizing the correlation coefficient in each breathing cycle and averaging over all cycles. Time-lag-induced discrepancy between internal SI position and that predicted from the external signal (external prediction error) was also calculated. Mean ± standard deviation time lag, over all scans and patients, was 0.10 ± 0.07 s (range 0.01-0.36 s). External signal lagged the internal in 17/18 scans. Change in time lag between pre- and post-treatment CBCT was 0.06 ± 0.07 s (range 0.01-0.22 s), corresponding to 3.1% ± 3.7% (range 0.6%-10.8%) of gate width (range 1.6-3.1 s). In only one patient, change in time lag exceeded 10% of the gate width. External prediction error over all scans of all patients varied from 0.1 ± 0.1 to 1.6 ± 0.4 mm. Time lag between internal motion along SI and external signals is small compared to the treatment gate width of abdominal patients examined in this study. Change in time lag within a treatment session, inferred from pre- to post-treatment measurements is also small, suggesting that a single measurement of time lag at the session start is adequate. These findings require confirmation in a larger number of patients.

  17. Technical Note: Intrafractional changes in time lag relationship between anterior–posterior external and superior–inferior internal motion signals in abdominal tumor sites

    PubMed Central

    Regmi, Rajesh; Lovelock, D. Michael; Zhang, Pengpeng; Pham, Hai; Xiong, Jianping; Yorke, Ellen D.; Goodman, Karyn A.; Wu, Abraham J.; Mageras, Gig S.

    2015-01-01

    Purpose: To investigate constancy, within a treatment session, of the time lag relationship between implanted markers in abdominal tumors and an external motion surrogate. Methods: Six gastroesophageal junction and three pancreatic cancer patients (IRB-approved protocol) received two cone-beam CTs (CBCT), one before and one after treatment. Time between scans was less than 30 min. Each patient had at least one implanted fiducial marker near the tumor. In all scans, abdominal displacement (Varian RPM) was recorded as the external motion signal. Purpose-built software tracked fiducials, representing internal signal, in CBCT projection images. Time lag between superior–inferior (SI) internal and anterior–posterior external signals was found by maximizing the correlation coefficient in each breathing cycle and averaging over all cycles. Time-lag-induced discrepancy between internal SI position and that predicted from the external signal (external prediction error) was also calculated. Results: Mean ± standard deviation time lag, over all scans and patients, was 0.10 ± 0.07 s (range 0.01–0.36 s). External signal lagged the internal in 17/18 scans. Change in time lag between pre- and post-treatment CBCT was 0.06 ± 0.07 s (range 0.01–0.22 s), corresponding to 3.1% ± 3.7% (range 0.6%–10.8%) of gate width (range 1.6–3.1 s). In only one patient, change in time lag exceeded 10% of the gate width. External prediction error over all scans of all patients varied from 0.1 ± 0.1 to 1.6 ± 0.4 mm. Conclusions: Time lag between internal motion along SI and external signals is small compared to the treatment gate width of abdominal patients examined in this study. Change in time lag within a treatment session, inferred from pre- to post-treatment measurements is also small, suggesting that a single measurement of time lag at the session start is adequate. These findings require confirmation in a larger number of patients. PMID:26127033

  18. Reentrainment of the circadian pacemaker during jet lag: East-west asymmetry and the effects of north-south travel.

    PubMed

    Diekman, Casey O; Bose, Amitabha

    2018-01-21

    The normal alignment of circadian rhythms with the 24-h light-dark cycle is disrupted after rapid travel between home and destination time zones, leading to sleep problems, indigestion, and other symptoms collectively known as jet lag. Using mathematical and computational analysis, we study the process of reentrainment to the light-dark cycle of the destination time zone in a model of the human circadian pacemaker. We calculate the reentrainment time for travel between any two points on the globe at any time of the day and year. We construct one-dimensional entrainment maps to explain several properties of jet lag, such as why most people experience worse jet lag after traveling east than west. We show that this east-west asymmetry depends on the endogenous period of the traveler's circadian clock as well as daylength. Thus the critical factor is not simply whether the endogenous period is greater than or less than 24 h as is commonly assumed. We show that the unstable fixed point of an entrainment map determines whether a traveler reentrains through phase advances or phase delays, providing an understanding of the threshold that separates orthodromic and antidromic modes of reentrainment. Contrary to the conventional wisdom that jet lag only occurs after east-west travel across multiple time zones, we predict that the change in daylength encountered during north-south travel can cause jet lag even when no time zones are crossed. Our techniques could be used to provide advice to travelers on how to minimize jet lag on trips involving multiple destinations and a combination of transmeridian and translatitudinal travel. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. The lead-lag relationship between stock index and stock index futures: A thermal optimal path method

    NASA Astrophysics Data System (ADS)

    Gong, Chen-Chen; Ji, Shen-Dan; Su, Li-Ling; Li, Sai-Ping; Ren, Fei

    2016-02-01

    The study of lead-lag relationship between stock index and stock index futures is of great importance for its wide application in hedging and portfolio investments. Previous works mainly use conventional methods like Granger causality test, GARCH model and error correction model, and focus on the causality relation between the index and futures in a certain period. By using a non-parametric approach-thermal optimal path (TOP) method, we study the lead-lag relationship between China Securities Index 300 (CSI 300), Hang Seng Index (HSI), Standard and Poor 500 (S&P 500) Index and their associated futures to reveal the variance of their relationship over time. Our finding shows evidence of pronounced futures leadership for well established index futures, namely HSI and S&P 500 index futures, while index of developing market like CSI 300 has pronounced leadership. We offer an explanation based on the measure of an indicator which quantifies the differences between spot and futures prices for the surge of lead-lag function. Our results provide new perspectives for the understanding of the dynamical evolution of lead-lag relationship between stock index and stock index futures, which is valuable for the study of market efficiency and its applications.

  20. Consistency of near-death experience accounts over two decades: are reports embellished over time?

    PubMed

    Greyson, Bruce

    2007-06-01

    "Near-death experiences," commonly reported after clinical death and resuscitation, may require intervention and, if reliable, may elucidate altered brain functioning under extreme stress. It has been speculated that accounts of near-death experiences are exaggerated over the years. The objective of this study was to test the reliability over two decades of accounts of near-death experiences. Seventy-two patients with near-death experience who had completed the NDE scale in the 1980s (63% of the original cohort still alive) completed the scale a second time, without reference to the original scale administration. The primary outcome was differences in NDE scale scores on the two administrations. The secondary outcome was the statistical association between differences in scores and years elapsed between the two administrations. Mean scores did not change significantly on the total NDE scale, its 4 factors, or its 16 items. Correlation coefficients between scores on the two administrations were significant at P<0.001 for the total NDE scale, for its 4 factors, and for its 16 items. Correlation coefficients between score changes and time elapsed between the two administrations were not significant for the total NDE scale, for its 4 factors, or for its 16 items. Contrary to expectation, accounts of near-death experiences, and particularly reports of their positive affect, were not embellished over a period of almost two decades. These data support the reliability of near-death experience accounts.

  1. Palm oil price forecasting model: An autoregressive distributed lag (ARDL) approach

    NASA Astrophysics Data System (ADS)

    Hamid, Mohd Fahmi Abdul; Shabri, Ani

    2017-05-01

    Palm oil price fluctuated without any clear trend or cyclical pattern in the last few decades. The instability of food commodities price causes it to change rapidly over time. This paper attempts to develop Autoregressive Distributed Lag (ARDL) model in modeling and forecasting the price of palm oil. In order to use ARDL as a forecasting model, this paper modifies the data structure where we only consider lagged explanatory variables to explain the variation in palm oil price. We then compare the performance of this ARDL model with a benchmark model namely ARIMA in term of their comparative forecasting accuracy. This paper also utilize ARDL bound testing approach to co-integration in examining the short run and long run relationship between palm oil price and its determinant; production, stock, and price of soybean as the substitute of palm oil and price of crude oil. The comparative forecasting accuracy suggests that ARDL model has a better forecasting accuracy compared to ARIMA.

  2. Urban mass transportation industry uniform system of accounts and records and reporting system. Volume I. General description.

    DOT National Transportation Integrated Search

    1977-01-10

    The purpose of the report is to present and document the detailed features of the uniform system of accounts and records and reporting system required by Section 15 of the Urban Mass Transportation Act of 1964, as amended. This report is presented in...

  3. 46 CFR 232.5 - Income Statement Accounts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACTIVITIES UNIFORM FINANCIAL REPORTING REQUIREMENTS Income Statement § 232.5 Income Statement Accounts. (a... Expense Accounts. The income and expense accounts shall show for each reporting period the amount of money... accounted for to facilitate reporting the source of revenue by trade route or service area. (iii) All other...

  4. The lagRST Model: A Turbulence Model for Non-Equilibrium Flows

    NASA Technical Reports Server (NTRS)

    Lillard, Randolph P.; Oliver, A. Brandon; Olsen, Michael E.; Blaisdell, Gregory A.; Lyrintzis, Anastasios S.

    2011-01-01

    This study presents a new class of turbulence model designed for wall bounded, high Reynolds number flows with separation. The model addresses deficiencies seen in the modeling of nonequilibrium turbulent flows. These flows generally have variable adverse pressure gradients which cause the turbulent quantities to react at a finite rate to changes in the mean flow quantities. This "lag" in the response of the turbulent quantities can t be modeled by most standard turbulence models, which are designed to model equilibrium turbulent boundary layers. The model presented uses a standard 2-equation model as the baseline for turbulent equilibrium calculations, but adds transport equations to account directly for non-equilibrium effects in the Reynolds Stress Tensor (RST) that are seen in large pressure gradients involving shock waves and separation. Comparisons are made to several standard turbulence modeling validation cases, including an incompressible boundary layer (both neutral and adverse pressure gradients), an incompressible mixing layer and a transonic bump flow. In addition, a hypersonic Shock Wave Turbulent Boundary Layer Interaction with separation is assessed along with a transonic capsule flow. Results show a substantial improvement over the baseline models for transonic separated flows. The results are mixed for the SWTBLI flows assessed. Separation predictions are not as good as the baseline models, but the over prediction of the peak heat flux downstream of the reattachment shock that plagues many models is reduced.

  5. Implications of Climate Change for State Bioassessment Programs and Approaches to Account for Effects (Final Report)

    EPA Science Inventory

    EPA announced the availability of the final report, Implications of Climate Change for State Bioassessment Programs and Approaches to Account for Effects. This report uses biological data collected by four states in wadeable rivers and streams to examine the components ...

  6. Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

    PubMed

    Noguchi, Yasunori; Yuan, Zuanning; Bai, Lin; Schneider, Sarah; Zhao, Gongpu; Stillman, Bruce; Speck, Christian; Li, Huilin

    2017-11-07

    During replication initiation, the core component of the helicase-the Mcm2-7 hexamer-is loaded on origin DNA as a double hexamer (DH). The two ring-shaped hexamers are staggered, leading to a kinked axial channel. How the origin DNA interacts with the axial channel is not understood, but the interaction could provide key insights into Mcm2-7 function and regulation. Here, we report the cryo-EM structure of the Mcm2-7 DH on dsDNA and show that the DNA is zigzagged inside the central channel. Several of the Mcm subunit DNA-binding loops, such as the oligosaccharide-oligonucleotide loops, helix 2 insertion loops, and presensor 1 (PS1) loops, are well defined, and many of them interact extensively with the DNA. The PS1 loops of Mcm 3, 4, 6, and 7, but not 2 and 5, engage the lagging strand with an approximate step size of one base per subunit. Staggered coupling of the two opposing hexamers positions the DNA right in front of the two Mcm2-Mcm5 gates, with each strand being pressed against one gate. The architecture suggests that lagging-strand extrusion initiates in the middle of the DH that is composed of the zinc finger domains of both hexamers. To convert the Mcm2-7 DH structure into the Mcm2-7 hexamer structure found in the active helicase, the N-tier ring of the Mcm2-7 hexamer in the DH-dsDNA needs to tilt and shift laterally. We suggest that these N-tier ring movements cause the DNA strand separation and lagging-strand extrusion. Copyright © 2017 the Author(s). Published by PNAS.

  7. 77 FR 39341 - Proposed Information Collection (Annual-Final Report and Account) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0017] Proposed Information Collection (Annual-Final Report and Account) Activity: Comment Request AGENCY: Veterans Benefits Administration, Department... of certain information by the agency. Under the Paperwork Reduction Act (PRA) of 1995, Federal...

  8. Heat conduction errors and time lag in cryogenic thermometer installations

    NASA Technical Reports Server (NTRS)

    Warshawsky, I.

    1973-01-01

    Installation practices are recommended that will increase rate of heat exchange between the thermometric sensing element and the cryogenic fluid, in addition to bringing about a reduction in the rate of undesired heat transfer to higher temperature objects. Formulas and numerical data are given that help to estimate the magnitude of heat conduction errors and of time lag in response.

  9. Pensacola Junior College Institutional Accountability Plan. Preliminary Five Year Plan Report, 1992-1993.

    ERIC Educational Resources Information Center

    Pensacola Junior Coll., FL. Office of Institutional Research and Effectiveness.

    Prepared in response to a Florida legislative mandate requiring the development and implementation of institutional accountability goals, this report presents the goals adopted by Pensacola Junior College (PJC), the college's plan of action, and data on progress made as of 1992-93 on the goals. Following an introduction, the first part presents…

  10. 14 CFR Section 01 - Authority Under Which Accounting and Reporting Rules and Regulations are Prescribed and Administered

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Authority Under Which Accounting and... SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 01 Authority Under Which... by air carriers; and it may employ special agents or auditors, who shall have authority under the...

  11. 14 CFR Section 01 - Authority Under Which Accounting and Reporting Rules and Regulations are Prescribed and Administered

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Authority Under Which Accounting and... SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 01 Authority Under Which... by air carriers; and it may employ special agents or auditors, who shall have authority under the...

  12. 14 CFR Section 01 - Authority Under Which Accounting and Reporting Rules and Regulations are Prescribed and Administered

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Authority Under Which Accounting and... SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS Section 01 Authority Under Which... by air carriers; and it may employ special agents or auditors, who shall have authority under the...

  13. 17 CFR 1.16 - Qualifications and reports of accountants.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... a futures commission merchant must be registered with the Public Company Accounting Oversight Board and must have undergone an examination by the Public Company Accounting Oversight Board, and may not... Accounting Oversight Board disciplinary hearing. (2) The Commission will not recognize any certified public...

  14. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis

    PubMed Central

    Reyes, Magdalena M.; Panza, Kaitlyn E.; Martin, Andrés; Bloch, Michael H.

    2013-01-01

    Objective To determine if there is evidence of a time-lag bias in the publication of pediatric antidepressant trials. Method We conducted a meta-analysis of published and unpublished randomized, placebo-controlled trials of serotonin reuptake inhibitors (SRIs) in subjects less than 18 years old with major depressive disorder. Our main outcomes were (1) time to publication of positive versus negative trials, and (2) proportion of treatment responders in trials with standard (< 3 years after study completion) versus delayed publication. Results We identified 15 randomized, placebo-controlled trials of SRIs for pediatric depression. Trials with negative findings had a significantly longer time to publication (median years ± standard deviation = 4.2 ±1.9) than trials with positive findings (2.2 ±0.9; log-rank χ2 = 4.35, p = 0.037). The estimated efficacy in trials with standard publication time (number needed to treat = 7, 95% CI: 5 – 11) was significantly greater than those with delayed publication (17, 95% CI: 9 – ∞; χ2 = 4.98, p = 0.025). The inflation-adjusted impact factor of journals for published trials with positive (15.33 ±11.01) and negative results (7.54 ±7.90) did not statistically differ (t = 1.4, df = 10, p = 0.17). Conclusions Despite a small number of trials of SRIs for pediatric antidepressants we found a significant evidence of time-lag bias in the publication of findings. This time-lag bias altered the perceived efficacy of pediatric antidepressants in the medical literature. Time-lag bias is not unique to child psychiatry and reflects a larger problem in scientific publishing. PMID:21156271

  15. Simplifying the diagnosis of 4 common voiding conditions using uroflow/electromyography, electromyography lag time and voiding history.

    PubMed

    Van Batavia, Jason P; Combs, Andrew J; Hyun, Grace; Bayer, Agnes; Medina-Kreppein, Daisy; Schlussel, Richard N; Glassberg, Kenneth I

    2011-10-01

    Noninvasive uroflowmetry with simultaneous electromyography is useful to triage cases of lower urinary tract symptoms into 4 urodynamically defined conditions, especially when incorporating short and long electromyography lag times in the analysis. We determined the prevalence of these 4 conditions at a single referral institution and the usefulness of uroflowmetry with simultaneous electromyography and electromyography lag time to confirm the diagnosis, guide treatment and monitor response. We retrospectively reviewed the records of 100 consecutive normal children who presented with persistent lower urinary tract symptoms, underwent uroflowmetry with electromyography as part of the initial evaluation and were diagnosed with 1 of 4 conditions based on certain uroflowmetry/electromyography features. The conditions included 1) dysfunctional voiding--active pelvic floor electromyography during voiding with or without staccato flow, 2a) idiopathic detrusor overactivity disorder-A--a quiet pelvic floor during voiding and shortened lag time (less than 2 seconds), 2b) idiopathic detrusor overactivity disorder-B--a quiet pelvic floor with a normal lag time, 3) detrusor underutilization disorder--volitionally deferred voiding with expanded bladder capacity but a quiet pelvic floor, and 4) primary bladder neck dysfunction--prolonged lag time (greater than 6 seconds) and a depressed, right shifted uroflowmetry curve with a quiet pelvic floor during voiding. Treatment was tailored to the underlying condition in each patient. The group consisted of 50 males and 50 females with a mean age of 8 years (range 3 to 18). Dysfunctional voiding was more common in females (p <0.05) while idiopathic detrusor overactivity disorder-B and primary bladder neck dysfunction were more common in males (p <0.01). With treatment uroflowmetry parameters normalized for all types. Electromyography lag time increased in idiopathic detrusor overactivity disorder-A cases and decreased in primary bladder

  16. CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

    PubMed Central

    Fromentin, Rémi; Bakeman, Wendy; Lawani, Mariam B.; Khoury, Gabriela; Hartogensis, Wendy; DaFonseca, Sandrina; Killian, Marisela; Epling, Lorrie; Hoh, Rebecca; Sinclair, Elizabeth; Hecht, Frederick M.; Bacchetti, Peter; Deeks, Steven G.; Lewin, Sharon R.; Sékaly, Rafick-Pierre; Chomont, Nicolas

    2016-01-01

    HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4+ T cells expressing immune checkpoint molecules would be enriched in HIV-infected cells in individuals receiving suppressive ART. Expression levels of 7 immune checkpoint molecules (PD-1, CTLA-4, LAG-3, TIGIT, TIM-3, CD160 and 2B4) as well as 4 markers of HIV persistence (integrated and total HIV DNA, 2-LTR circles and cell-associated unspliced HIV RNA) were measured in PBMCs from 48 virally suppressed individuals. Using negative binomial regression models, we identified PD-1, TIGIT and LAG-3 as immune checkpoint molecules positively associated with the frequency of CD4+ T cells harboring integrated HIV DNA. The frequency of CD4+ T cells co-expressing PD-1, TIGIT and LAG-3 independently predicted the frequency of cells harboring integrated HIV DNA. Quantification of HIV genomes in highly purified cell subsets from blood further revealed that expressions of PD-1, TIGIT and LAG-3 were associated with HIV-infected cells in distinct memory CD4+ T cell subsets. CD4+ T cells co-expressing the three markers were highly enriched for integrated viral genomes (median of 8.2 fold compared to total CD4+ T cells). Importantly, most cells carrying inducible HIV genomes expressed at least one of these markers (median contribution of cells expressing LAG-3, PD-1 or TIGIT to the inducible reservoir = 76%). Our data provide evidence that CD4+ T cells expressing PD-1, TIGIT and LAG-3 alone or in combination are enriched for persistent HIV during ART and suggest that immune checkpoint blockers directed against these receptors may represent valuable tools to target latently infected cells in virally suppressed individuals. PMID:27415008

  17. Simultaneous pharmacodynamic analysis of the lag and bactericidal phases exhibited by beta-lactams against Escherichia coli.

    PubMed Central

    Li, R C

    1996-01-01

    Antibiotic-bacterium interactions are complex in nature. In many cases, bacterial killing does not commence immediately after the addition of an antibiotic, and a lag period is observed. Antibiotic permeation and/or the intermediate steps that exist between antibiotic-receptor binding and expression of cell death are two major possible causes for such lag period. This study was primarily designed to determine the relationship, if any, between antibiotic concentrations and the lag periods by a modeling approach. Short-term time-kill studies were conducted for amoxicillin, ampicillin, penicillin-G, oxacillin, and dicloxacillin against Escherichia coli. In conjunction with the use of a saturable rate model to describe the concentration-dependent killing process, a first-order induction (initiation) rate constant was used to characterize the delay in bacterial killing during the lag period. For all of the beta-lactams tested, parameters describing the bactericidal effect suggest that amoxicillin and ampicillin were much more potent than oxacillin and dicloxacillin. The induction rate constant estimates for both ampicillin and amoxicillin were found to relate linearly to concentrations. Nevertheless, these induction rate constant estimates were lower for penicillin-G, oxacillin, and dicloxacillin and increased nonlinearly with concentrations until an apparent plateau was observed. These findings support the hypothesis that the permeation process is potentially a rate-limiting step for the rapid bactericidal beta-lactams such as ampicillin and amoxicillin. However, as suggested by previous observations of the various morphological changes induced by beta-lactams, the contribution of the steps following antibiotic-receptor complex formation to the lag period might be significant for the less bactericidal antibiotics such as oxacillin and dicloxacillin. Findings from the present modeling approach can potentially be used to guide future bench experimentation. PMID:8891135

  18. How "accountable" are accountable care organizations?

    PubMed

    Addicott, Rachael; Shortell, Stephen M

    2014-01-01

    The establishment of accountable care organizations (ACOs) in the Affordable Care Act (ACA) was intended to support both cost savings and high-quality care. However, a key challenge will be to ensure that governance and accountability mechanisms are sufficient to support those twin ambitions. This exploratory study considers how recently developed ACOs have established governance structures and accountability mechanisms, particularly focusing on attempts at collaborative accountability and shared governance arrangements. Four case studies of ACOs across the United States were undertaken, with data collected throughout 2012. These involved 34 semistructured interviews with ACO administrative and clinical leaders, observation of nine meetings, and a review of documentary materials from each ACO. We identified very few examples of physicians being held to account as a collective and therefore only limited evidence of collaborative accountability impacting on behavior change. However, ACO leaders do have many mechanisms available to stimulate change across physicians. The challenge is to determine governance structure(s) and accountability mechanisms that facilitate the most effective combination of approaches, measures, incentives, and sanctions to achieve the goals of more accountable care. Accountability structures and processes will need to be tailored to local membership composition, historical evolution, and current stage of development. There are also some common lessons to be drawn. Shared goals and incentives should be reflected through performance criteria. It is important to align measures and thresholds across payers to ensure ACOs are not unnecessarily burdened or compromised by reporting on different and potentially disjointed measures. Finally, emphasis needs to be placed on the importance of credible, transparent data. This exploratory study provides early evidence regarding how ACOs are establishing their governance and accountability arrangements and

  19. Report: Congressionally Requested Inquiry Into the EPA’s Use of Private and Alias Email Accounts

    EPA Pesticide Factsheets

    Report #13-P-0433, September 26, 2013. We found no evidence that the EPA used, promoted or encouraged the use of private “non-governmental” email accounts to circumvent records management responsibilities

  20. 75 FR 54801 - Account Ownership and Control Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

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  1. Non-suicidal reasons for self-harm: A systematic review of self-reported accounts.

    PubMed

    Edmondson, Amanda J; Brennan, Cathy A; House, Allan O

    2016-02-01

    Self-harm is a major public health problem yet current healthcare provision is widely regarded as inadequate. One of the barriers to effective healthcare is the lack of a clear understanding of the functions self-harm may serve for the individual. The aim of this review is to identify first-hand accounts of the reasons for self-harm from the individual's perspective. A systematic review of the literature reporting first-hand accounts of the reasons for self-harm other than intent to die. A thematic analysis and 'best fit' framework synthesis was undertaken to classify the responses. The most widely researched non-suicidal reasons for self-harm were dealing with distress and exerting interpersonal influence. However, many first-hand accounts included reasons such as self-validation, and self-harm to achieve a personal sense of mastery, which suggests individuals thought there were positive or adaptive functions of the act not based only on its social effects. Associations with different sub-population characteristics or with the method of harm were not available from most studies included in the analysis. Our review identified a number of themes that are relatively neglected in discussions about self-harm, which we summarised as self-harm as a positiveexperience and defining the self. These self-reported "positive" reasons may be important in understanding and responding especially to repeated acts of self-harm. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  2. Thermal infrared and visual observations of a water ice lag in the Mars southern summer

    USGS Publications Warehouse

    Titus, T.N.

    2005-01-01

    We present thermal infrared and visual evidence for the existence of water ice lags in the early southern summer. The observed H2O-ice lags lay in and near a chasma and appears to survive between 6-8 sols past the sublimation of the CO2. Possible sources of the H2O that compose the lag are (1) atmospheric H2O that is incorporated into the seasonal cap during condensation, (2) cold trapping of atmospheric water vapor onto the surface of the cap in the spring, or (3) a combination of the 2 processes where water is released from the sublimating cap only to be transported back over the cap edge and cold trapped. We refer to this later process as the "Houben" effect which may enrich the amount of water contained in the seasonal cap at 85??S by as much as a factor of 15. This phenomenon, which has already been identified for the northern retreating cap, may present an important water transport mechanism in the Southern Hemisphere.

  3. High-angle-of-attack pneumatic lag and upwash corrections for a hemispherical flow direction sensor

    NASA Technical Reports Server (NTRS)

    Whitmore, Stephen A.; Heeg, Jennifer; Larson, Terry J.; Ehernberger, L. J.; Hagen, Floyd W.; Deleo, Richard V.

    1987-01-01

    As part of the NASA F-14 high angle of attack flight test program, a nose mounted hemispherical flow direction sensor was calibrated against a fuselage mounted movable vane flow angle sensor. Significant discrepancies were found to exist in the angle of attack measurements. A two fold approach taken to resolve these discrepancies during subsonic flight is described. First, the sensing integrity of the isolated hemispherical sensor is established by wind tunnel data extending to an angle of attack of 60 deg. Second, two probable causes for the discrepancies, pneumatic lag and upwash, are examined. Methods of identifying and compensating for lag and upwash are presented. The wind tunnel data verify that the isolated hemispherical sensor is sufficiently accurate for static conditions with angles of attack up to 60 deg and angles of sideslip up to 30 deg. Analysis of flight data for two high angle of attack maneuvers establishes that pneumatic lag and upwash are highly correlated with the discrepancies between the hemispherical and vane type sensor measurements.

  4. The Evolution of the Phase Lags Associated with the Type-C Quasi-periodic Oscillation in GX 339–4 during the 2006/2007 Outburst

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Liang; Chen, Li; Wang, Yanan

    2017-08-20

    We present the evolution of the phase lags associated with the type-C QPO in GX 339–4 during the rising phase of the 2006/2007 outburst. We find that the phase lags at the QPO frequency are always positive (hard) and show very different behavior between QPOs with frequencies below and above ∼1.7 Hz: when the QPO frequency is below ∼1.7 Hz, the phase lags increase both with QPO frequency and energy, while when the QPO frequency is above ∼1.7 Hz, the phase lags remain more or less constant. When the QPO frequency is higher than ∼1.7 Hz, a broad feature ismore » always present in the lag–energy spectra at around 6.5 keV, suggesting that the reflection component may have a significant contribution to the phase lags. Below ∼1.7 Hz, the QPO rms first decreases with energy and then turns to almost flat, while above ∼1.7 Hz, the QPO rms increases with energy. During the transition from the low-hard state to the hard-intermediate state, the second harmonic and subharmonic of this QPO appear in the power density spectra. The second-harmonic and subharmonic phase lags show very similar evolutions for their centroid frequencies. However, the energy dependence of the second-harmonic and subharmonic phase lags are quite different. Our results suggest that, at different phases of the outburst, different mechanisms may be responsible for the phase lags of the QPO. We briefly discuss the possible scenarios for producing the lags.« less

  5. High-throughput Analysis of Ultrasonication-forced Amyloid Fibrillation Reveals the Mechanism Underlying the Large Fluctuation in the Lag Time*

    PubMed Central

    Umemoto, Ayaka; Yagi, Hisashi; So, Masatomo; Goto, Yuji

    2014-01-01

    Amyloid fibrils form in supersaturated solutions of precursor proteins by a nucleation and growth mechanism characterized by a lag time. Although the lag time provides a clue to understanding the complexity of nucleation events, its long period and low reproducibility have been obstacles for exact analysis. Ultrasonication is known to effectively break supersaturation and force fibrillation. By constructing a Handai amyloid burst inducer, which combines a water bath-type ultrasonicator and a microplate reader, we examined the ultrasonication-forced fibrillation of several proteins, with a focus on the fluctuation in the lag time. Amyloid fibrillation of hen egg white lysozyme was examined at pH 2.0 in the presence of 1.0–5.0 M guanidine hydrochloride (GdnHCl), in which the dominant species varied from the native to denatured conformations. Although fibrillation occurred at various concentrations of GdnHCl, the lag time varied largely, with a minimum being observed at ∼3.0 m, the concentration at which GdnHCl-dependent denaturation ended. The coefficient of variation of the lag time did not depend significantly on the GdnHCl concentration and was 2-fold larger than that of the ultrasonication-dependent oxidation of iodide, a simple model reaction. These results suggest that the large fluctuation observed in the lag time for amyloid fibrillation originated from a process associated with a common amyloidogenic intermediate, which may have been a relatively compact denatured conformation. We also suggest that the Handai amyloid burst inducer system will be useful for studying the mechanism of crystallization of proteins because proteins form crystals by the same mechanism as amyloid fibrils under supersaturation. PMID:25118286

  6. Evolution of the reverberation lag in GX 339-4 at the end of an outburst

    NASA Astrophysics Data System (ADS)

    De Marco, B.; Ponti, G.; Petrucci, P. O.; Clavel, M.; Corbel, S.; Belmont, R.; Chakravorty, S.; Coriat, M.; Drappeau, S.; Ferreira, J.; Henri, G.; Malzac, J.; Rodriguez, J.; Tomsick, J. A.; Ursini, F.; Zdziarski, A. A.

    2017-10-01

    We studied X-ray reverberation lags in the Black hole X-ray binary (BHXRB) GX 339-4 at the end of the 2014-2015 outburst. We analysed data from an XMM-Newton campaign covering the end of the transition from the soft to hard state, and the decrease of luminosity in the hard state. During all the observations we detected, at high frequencies, significant disc variability, responding to variations of the power-law emission with an average time delay of ∼0.009 ± 0.002 s. These new detections of disc thermal reverberation add to those previously obtained and suggest the lag to be always present in hard and hard-intermediate states. Our study reveals a net decrease of lag amplitude as a function of luminosity. We ascribe this trend to variations of the inner flow geometry. A possible scenario implies a decrease of the inner disc truncation radius as the luminosity increases at the beginning of the outburst, followed by an increase of the inner disc truncation radius as the luminosity decreases at the end of the outburst. Finally, we found hints of FeK reverberation (∼3σ significance) during the best quality observation of the XMM monitoring. The lag at the FeK energy has similar amplitude as that of the thermally reprocessed component, as expected if the same irradiated region of the disc is responsible for producing both the thermalized and reflected components. This finding suggests FeK reverberation in BHXRBs to be at the reach of current detectors provided observations of sufficiently long exposure are available.

  7. AN INTEGRATED MODEL FOR THE PRODUCTION OF X-RAY TIME LAGS AND QUIESCENT SPECTRA FROM HOMOGENEOUS AND INHOMOGENEOUS BLACK HOLE ACCRETION CORONAE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kroon, John J.; Becker, Peter A., E-mail: jkroon@gmu.edu, E-mail: pbecker@gmu.edu

    2016-04-20

    Many accreting black holes manifest time lags during outbursts, in which the hard Fourier component typically lags behind the soft component. Despite decades of observations of this phenomenon, the underlying physical explanation for the time lags has remained elusive, although there are suggestions that Compton reverberation plays an important role. However, the lack of analytical solutions has hindered the interpretation of the available data. In this paper, we investigate the generation of X-ray time lags in Compton scattering coronae using a new mathematical approach based on analysis of the Fourier-transformed transport equation. By solving this equation, we obtain the Fouriermore » transform of the radiation Green’s function, which allows us to calculate the exact dependence of the time lags on the Fourier frequency, for both homogeneous and inhomogeneous coronal clouds. We use the new formalism to explore a variety of injection scenarios, including both monochromatic and broadband (bremsstrahlung) seed photon injection. We show that our model can successfully reproduce both the observed time lags and the time-averaged (quiescent) X-ray spectra for Cyg X-1 and GX 339-04, using a single set of coronal parameters for each source. The time lags are the result of impulsive bremsstrahlung injection occurring near the outer edge of the corona, while the time-averaged spectra are the result of continual distributed injection of soft photons throughout the cloud.« less

  8. Quantifying the effect of water activity and storage temperature on single spore lag times of three moulds isolated from spoiled bakery products.

    PubMed

    Dagnas, Stéphane; Gougouli, Maria; Onno, Bernard; Koutsoumanis, Konstantinos P; Membré, Jeanne-Marie

    2017-01-02

    The inhibitory effect of water activity (a w ) and storage temperature on single spore lag times of Aspergillus niger, Eurotium repens (Aspergillus pseudoglaucus) and Penicillium corylophilum strains isolated from spoiled bakery products, was quantified. A full factorial design was set up for each strain. Data were collected at levels of a w varying from 0.80 to 0.98 and temperature from 15 to 35°C. Experiments were performed on malt agar, at pH5.5. When growth was observed, ca 20 individual growth kinetics per condition were recorded up to 35days. Radius of the colony vs time was then fitted with the Buchanan primary model. For each experimental condition, a lag time variability was observed, it was characterized by its mean, standard deviation (sd) and 5 th percentile, after a Normal distribution fit. As the environmental conditions became stressful (e.g. storage temperature and a w lower), mean and sd of single spore lag time distribution increased, indicating longer lag times and higher variability. The relationship between mean and sd followed a monotonous but not linear pattern, identical whatever the species. Next, secondary models were deployed to estimate the cardinal values (minimal, optimal and maximal temperatures, minimal water activity where no growth is observed anymore) for the three species. That enabled to confirm the observation made based on raw data analysis: concerning the temperature effect, A. niger behaviour was significantly different from E. repens and P. corylophilum: T opt of 37.4°C (standard deviation 1.4°C) instead of 27.1°C (1.4°C) and 25.2°C (1.2°C), respectively. Concerning the a w effect, from the three mould species, E. repens was the species able to grow at the lowest a w (aw min estimated to 0.74 (0.02)). Finally, results obtained with single spores were compared to findings from a previous study carried out at the population level (Dagnas et al., 2014). For short lag times (≤5days), there was no difference between lag

  9. Unilateral lag screw fixation of isolated non-union atlas lateral mass fracture: a new technical note.

    PubMed

    Farrokhi, Majid Reza; Kiani, Arash; Rezaei, Hamid

    2018-01-15

    We describe a novel and new technique of posterior unilateral lag screw fixation of non-union atlas lateral mass fracture. A 46-year-old man presented with cervical pain and tenderness after a vehicle turn over accident and he was diagnosed to have left atlas lateral mass fracture. He was initially treated by immobilization using Minerva orthosis. About 2 months later, he developed severe neck pain and limitation of motion and thus he was scheduled for operation due to non-union atlas lateral mass fracture. A 28 mm lag screw was inserted under anterior-posterior and lateral fluoroscopic views. The entrance point was at the dorsal aspect of left atlas posterior arc at its junction to the lateral mass, and by using the trajectory of 10 degrees medial and 22 degrees cephalad fracture reduction was achieved. Unilateral lag screw fixation of atlas fractures is an appropriate, safe and effective surgical technique for the management of unilateral atlas fractures.

  10. Canadian Universities Lag behind U.S. in Financing, Report Says

    ERIC Educational Resources Information Center

    Birchard, Karen

    2008-01-01

    This article focuses on a report by the Association of Universities and Colleges of Canada which states that four-year public colleges in the United States have significantly more resources for teaching and research than do their counterparts in Australia, Canada, and Britain. According to the report, "Trends in Higher Education: Volume 3:…

  11. Transparency & Accountability: An Evaluation of the VSA College Portrait Pilot. A Special Report from the National Institute for Learning Outcomes Assessment for the Voluntary System of Accountability

    ERIC Educational Resources Information Center

    Jankowski, Natasha A.; Ikenberry, Stanley O.; Kinzie, Jillian; Kuh, George D.; Shenoy, Gloria F.; Baker, Gianina R.

    2012-01-01

    The Voluntary System of Accountability (VSA) is a vehicle for public four-year universities to report comparable information about the undergraduate student experience via the College Portrait, a common web reporting template. The National Institute for Learning Outcomes Assessment (NILOA) was asked by the VSA to evaluate the effectiveness of the…

  12. Climate legacy and lag effects on dryland plant communities in the southwestern U.S.

    USGS Publications Warehouse

    Bunting, Erin; Munson, Seth M.; Villarreal, Miguel

    2017-01-01

    Climate change effects on vegetation will likely be strong in the southwestern U.S., which is projected to experience large increases in temperature and changes in precipitation. Plant communities in the southwestern U.S. may be particularly vulnerable to climate change as the productivity of many plant species is strongly water-limited. This study examines the relationship between climate and vegetation condition using a time-series of Landsat imagery across grassland, shrubland, and woodland communities on the Colorado Plateau, USA. We improve on poorly understood inter-annual climate-vegetation relationships by exploring how the responses of different plant communities depend on climate legacies (>12 months) and lag behind shorter-term (3–12 month) changes in water availability. Our results show a prolonged drying trend on the Colorado Plateau since the early 1990s that was punctuated in several years by intense droughts. In areas that experienced sustained dry conditions or a drying trend, vegetation greenness (a proxy for production) increased linearly when conditions were interrupted by wetting events. In contrast, in areas that experienced sustained wet conditions or a wetting trend, vegetation greenness was weakly or not related to wetting events, indicating that production may saturate if vegetation experiences sufficient water availability. Shrubland and woodland communities had stronger relationships with climate at long lags (6–12 months) and many maintained greenness under sustained water deficit, whereas grassland communities had stronger relationships at short lags (3–6 months) and lost greenness even in periods of short-term drought. The results of our study show the importance of identifying climate legacies and lags when assessing indicators of ecological drought, which can be used to improve forecasts of which plant communities will be vulnerable under future climate change.

  13. The lagged effect of cold temperature and wind chill on cardiorespiratory mortality in Scotland

    PubMed Central

    Carder, M; McNamee, R; Beverland, I; Elton, R; Cohen, G; Boyd, J; Agius, R

    2005-01-01

    Aims: To investigate the lagged effects of cold temperature on cardiorespiratory mortality and to determine whether "wind chill" is a better predictor of these effects than "dry bulb" temperature. Methods: Generalised linear Poisson regression models were used to investigate the relation between mortality and "dry bulb" and "wind chill" temperatures in the three largest Scottish cities (Glasgow, Edinburgh, and Aberdeen) between January 1981 and December 2001. Effects of temperature on mortality (lags up to one month) were quantified. Analyses were conducted for the whole year and by season (cool and warm seasons). Main results: Temperature was a significant predictor of mortality with the strongest association observed between temperature and respiratory mortality. There was a non-linear association between mortality and temperature. Mortality increased as temperatures fell throughout the range, but the rate of increase was steeper at temperatures below 11°C. The association between temperature and mortality persisted at lag periods beyond two weeks but the effect size generally decreased with increasing lag. For temperatures below 11°C, a 1°C drop in the daytime mean temperature on any one day was associated with an increase in mortality of 2.9% (95% CI 2.5 to 3.4), 3.4% (95% CI 2.6 to 4.1), 4.8% (95% CI 3.5 to 6.2) and 1.7% (95% CI 1.0 to 2.4) over the following month for all cause, cardiovascular, respiratory, and "other" cause mortality respectively. The effect of temperature on mortality was not observed to be significantly modified by season. There was little indication that "wind chill" temperature was a better predictor of mortality than "dry bulb" temperature. Conclusions: Exposure to cold temperature is an important public health problem in Scotland, particularly for those dying from respiratory disease. PMID:16169916

  14. Distinctive time-lagged resting-state networks revealed by simultaneous EEG-fMRI.

    PubMed

    Feige, Bernd; Spiegelhalder, Kai; Kiemen, Andrea; Bosch, Oliver G; Tebartz van Elst, Ludger; Hennig, Jürgen; Seifritz, Erich; Riemann, Dieter

    2017-01-15

    Functional activation as evidenced by blood oxygen level-dependent (BOLD) functional MRI changes or event-related EEG is known to closely follow patterns of stimulation or self-paced action. Any lags are compatible with axonal conduction velocities and neural integration times. The important analysis of resting state networks is generally based on the assumption that these principles also hold for spontaneous fluctuations in brain activity. Previous observations using simultaneous EEG and fMRI indicate that slower processes, with delays in the seconds range, determine at least part of the relationship between spontaneous EEG and fMRI. To assess this relationship systematically, we used deconvolution analysis of EEG-fMRI during the resting state, assessing the relationship between EEG frequency bands and fMRI BOLD across the whole brain while allowing for time lags of up to 10.5s. Cluster analysis, identifying similar BOLD time courses in relation to EEG band power peaks, showed a clear segregation of functional subsystems of the brain. Our analysis shows that fMRI BOLD increases commonly precede EEG power increases by seconds. Most zero-lag correlations, on the other hand, were negative. This indicates two main distinct neuromodulatory mechanisms: an "idling" mechanism of simultaneous electric and metabolic network anticorrelation and a "regulatory" mechanism in which metabolic network activity precedes increased EEG power by some seconds. This has to be taken into consideration in further studies which address the causal and functional relationship of metabolic and electric brain activity patterns. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Immediate or lagged responses of a red squirrel population to pulsed resources.

    PubMed

    Selonen, Vesa; Varjonen, Rauno; Korpimäki, Erkki

    2015-02-01

    According to producer-consumer models, consumers should follow pulsed resources with a time lag. This view has been challenged by studies demonstrating that individuals may anticipate future resource pulses by increasing reproduction just before the pulse. We studied population fluctuations and reproduction in European red squirrels, Sciurus vulgaris, in relation to seed masting of the main food resource (the Norway spruce) in boreal coniferous forests between 1979 and 2013. Red squirrels are pre-dispersal seed predators, and previous studies have shown that they can anticipate the coming seed mast. We did not find any indication that anticipation of masting (year t ) increased red squirrel reproduction in the preceding spring to early summer. Instead, the reproductive output of the squirrels was highest in the spring following the mast, indicating that the population had to be at its largest size in the autumn after the mast (year(t+1)), when lots of subadults were around. However, we surmised, based on snow tracks and squirrel nest data, that the population crashed during the following winter (year(t+1)). These data reflected the adult population during winter, which peaked at the same time as the resource pulse. We can therefore conclude that the time lag between the resource pulse and the attainment of the peak number of squirrels was less than one year, and that the resource crash affected more juveniles and subadults than adults. The population increase overlapped with the occurrence of masting, but there was also a lagged response, supporting the classical view of producer-consumer models.

  16. A Randomized Trial Using Progressive Addition Lenses to Evaluate Theories of Myopia Progression in Children with a High Lag of Accommodation

    PubMed Central

    Sinnott, Loraine T.; Mutti, Donald O.; Zadnik, Karla

    2012-01-01

    Purpose. To compare the effect of wearing, then ceasing to wear, progressive addition lenses (PALs) versus single vision lenses (SVLs) on myopia progression in children with high accommodative lag to evaluate accommodative lag and mechanical tension as theories of myopia progression. Methods. Eighty-five children (age range, 6–11 years) with spherical equivalent (SE) cycloplegic autorefraction between −0.75 D and −4.50 D were randomly assigned to wear SVLs or PALs for 1 year; all children wore SVLs a second year. Children had high accommodative lag and also had near esophoria if their myopia was greater than −2.25 D SE. The primary outcome after each year was the previous year's change in SE. Results. When the children were randomly assigned to SVLs or PALs, the adjusted 1-year changes in SE were −0.52 D (SVL group) and −0.35 D (PAL group; treatment effect = 0.18 D; P = 0.01). When all children wore SVLs the second year, there was no difference in myopia progression between SVL and former PAL wearers (0.06 D; P = 0.50). Accommodative lag was not associated with myopia progression. Conclusions. The statistically significant, but clinically small, PAL effect suggests that treatments aimed at reducing foveal defocus may not be as effective as previously thought in myopic children with high accommodative lag. Finding no evidence of treatment loss after discontinuing PAL wear supports hyperopic defocus-based theories such as accommodative lag; however, not finding an association between accommodative lag and myopia progression is inconsistent with the PAL effect being due to decreased foveal blur during near work. (Clinical Trials.gov number, NCT00335049.) PMID:22205604

  17. State and Local Implementation of the "No Child Left Behind Act." Volume III--Accountability under "NCLB" Interim Report

    ERIC Educational Resources Information Center

    Le Floch, Kerstin Carlson; Martinez, Felipe; O'Day, Jennifer; Stecher, Brian; Taylor, James; Cook, Andrea

    2007-01-01

    This report presents findings about accountability from two longitudinal studies, the National Longitudinal Study of "No Child Left Behind" (NLS-"NCLB"), and the Study of State Implementation of Accountability and Teacher Quality Under "No Child Left Behind" (SSI-"NCLB"). The research teams for these two…

  18. "Accounting Education at a Crossroad in 2010" and "Challenges Facing Accounting Education in Australia"

    ERIC Educational Resources Information Center

    de Lange, Paul; Watty, Kim

    2011-01-01

    Of the various reports released in 2010, two purport to examine the state of accounting education in Australia. These are "Accounting Education at a Crossroad in 2010" and "Challenges Facing Accounting Education in Australia". Both were released as collaborations of the leading academic organisation, the Accounting and Finance…

  19. Report: Wells Band Council Needs to Improve Its Accounting System to Comply With Federal Regulations

    EPA Pesticide Factsheets

    Report #14-2-0316, July 14, 2014. The Wells Band Council’s accounting system did not comply with federal regulations, which resulted in $390,000 of questioned costs and proposed high-risk designation for the grantee.

  20. Revamping High School Accounting Courses.

    ERIC Educational Resources Information Center

    Bittner, Joseph

    2002-01-01

    Provides ideas for updating accounting courses: convert to semester length; focus on financial reporting/analysis, financial statements, the accounting cycle; turn textbook exercises into practice sets for the accounting cycle; teach about corporate accounting; and address individual line items on financial statements. (SK)