Neuron Report Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal such as the nucleus accumbens (NAc). However, a direct role of dopamine in ICSS-mediated reward has been questioned that, at certain sites, the onset of anticipatory dopamine surges and changes in neuronal firing
E-print Network
Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. Total and vesicular levels of ...
PubMed Central
Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc, prevents a further ethanol-induced dopamine elevation and ...
PubMed
In Sprague-Dawley rats in was shown by means of in vivo microdialysis combined with HPLC-EC analysis that the blockade of D2-dopamine receptors of the n. accumbens by raclopride (10 microM) completely prevents a decrease in accumbal extracellular glutamate level induced by food intake. PMID:11548610
In well-trained animals, accumbal dopamine release is stimulated during operant ethanol self-administration, but the time course of development of this dopaminergic response, particularly during the acquisition of ethanol drinking behavior, remains unknown. To examine this, we trained male Long-Evans rats to self-administer 10% ethanol ...
IntroductionRecently we demonstrated that genetic or pharmacological suppression of the central ghrelin signaling system, involving the growth hormone secretagogue receptor 1A (GHS-R1A), lead to a reduced reward profile from alcohol. As the target circuits for ghrelin in the brain include a mesolimbic reward pathway that is intimately associated with reward-seeking behaviour, we sought to ...
Our study examined ethanol self-administration and accumbal dopamine concentration during ?-opioid receptor (KOPr) blockade. Long-Evans rats were trained to respond for 20 min of access to 10% ethanol (with sucrose) over 7 days. Rats were injected s.c. with the long-acting KOPr antagonist, nor-binaltorphimine (NOR-BNI; 0 or 20 mg/kg) 15�20 h prior to ...
Co., Woodland Hills, CA) was implanted into the left LDT of each mouse [coordinates: anteroposterior:278�284. Ferrari-Dileo G, Waelbroeck M, Mash DC, Flynn DD (1994) Selective labeling and localization of the M4 (m4 to the ventral tegmental area. J Neurosci 15:5859�5869. Reever CM, Ferrari-DiLeo G, Flynn DD (1997) The M5 (m5
A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin2C receptor (5-HT2CR) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT2CR located in the medial prefrontal ...
We have previously demonstrated that glycine receptors in the nucleus accumbens (nAc) are involved in modulating both basal and ethanol-induced dopamine output in the same brain region. Ethanol is known to induce a release of both taurine and dopamine in the nAc, but the relationship between these two neuromodulators has not been ...
The effects of the mu-receptor agonist fentanyl on extracellular levels of dopamine in rat nucleus accumbens were studied in awake animals by in vivo brain microdialysis. Fentanyl dose-dependently increased the levels of dopamine when given intravenously (microg/kg) or via a microdialysis probe placed into the ventral tegmental area or the nucleus ...
Dopamine (DA) neurotransmission in the nucleus accumbens (NAc) is critically involved in normal as well as maladaptive motivated behaviors including drug addiction. Whether the striatal neuromodulator nitric oxide (NO) influences DA release in NAc is unknown. We investigated whether exogenous NO modulates DA transmission in NAc core and how this ...
Recently, we demonstrated that the central ghrelin signalling system, involving the ghrelin receptor (GHS-R1A), is important for alcohol reinforcement. Ghrelin targets a key mesolimbic circuit involved in natural as well as drug-induced reinforcement, that includes a dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens. The aim of the present ...
Although exercise has been known to regulate brain plasticity, its impact on psychostimulant reward and the associated mesolimbic dopamine system remained scarcely explored. A psychostimulant, 3,4-methylenedioxymethamphetamine (MDMA), is currently a worldwide abused drug of choice. We decided to examine the modulating effects of long-term, compulsive treadmill exercise on the ...
Cocaine-conditioned memory has been known to cause cocaine craving and relapse, while its underlying mechanisms remain unclear. We explored accumbal protein candidates responsible for a cocaine-conditioned memory, cocaine-induced conditioned place preference (CPP). Two-dimensional gel electrophoresis in conjunction with liquid chromatography mass spectrometry analysis was ...
Neonatal quinpirole treatment to rats produces long-term increases in D(2) receptor sensitivity that persists throughout the animal's lifetime, a phenomenon referred to as D(2) priming. Male and female Sprague-dawley rats were administered quinpirole (1 mg kg(-1)) or saline from postnatal days (P)1-11. At P60, all animals were given an injection of quinpirole (100 microg kg(-1)), and results ...
The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central ghrelin signaling system is required for alcohol reward. Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcohol intake in a 2-bottle (alcohol/water) free choice limited access paradigm in ...
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding ...
Injection drug use accounts for approximately one-third of human immunodeficiency virus (HIV) infections in the United States. HIV-associated proteins have been shown to interact with various drugs of abuse to incite concerted neurotoxicity. One common area for their interaction is the nerve terminal, including dopamine transporter (DAT) systems. However, results regarding DAT ...
Ghrelin, preferably via hypothalamic circuits, is known to play a role in the control of energy balance, body weight homeostasis and appetite. In addition, it has recently been found that ghrelin injection into key structures of the mesolimbic dopamine (DA) system increases food intake in rodents and induces locomotor stimulation as well as accumbal DA ...
Intracerebral microdialysis was used to monitor dopamine release in rat striatal extracellular fluid
NASA Technical Reports Server (NTRS)
The effect of interactions among mu- and delta-opioid receptors, especially the putative delta(1)- and delta(2)-opioid receptors, in the nucleus accumbens on accumbal dopamine release was investigated in awake rats by in vivo brain microdialysis. In agreement with previous studies, perfusion of the nucleus accumbens with the mu-, ...
Dopamine has undergone extensive investigation due to its known involvement in a number of neurological and psychiatric disorders. In particular, studies into pathological conditions have focused on the roles of high amplitude, phasically evoked dopamine release in regions such as the prefrontal cortex and striatum. However, research ...
Neonatal quinpirole treatment to rats produces long-term increases in D2 receptor sensitivity that persists throughout the animal's lifetime, a phenomenon referred to as D2 priming. Male and female Sprague-dawley rats were administered quinpirole (1mg/kg) or saline from postnatal days (P)1�11. At P60, all animals were given an injection of quinpirole ...
Brief Communications Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid-3290 Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus
Short phasic bursts of neuronal activity in dopamine neurons produce rapid and transient increases in extracellular dopamine concentrations throughout the mesocorticolimbic system, which are associated with the initiation of goal-directed behaviors. It is well established that acute exposure to many addictive drugs produce increases in tonic ...
Studies have indicated that the metabotropic glutamate receptor 5 (mGluR5) antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) decreases ethanol self-administration, and the same receptor type was also suggested to be involved in the mechanism of action of the anti-craving substance acamprosate. Our previous research suggested that glycine receptors (GlyRs) in the nucleus accumbens (nAc) play a ...
Microdialysis and SPECT Measurements of Amphetamine-Induced Dopamine Release in Nonhuman Primates of Pennsylvania, Philadelphia, Pennsylvania 19904 KEY WORDS microdialysis; SPECT; amphetamine; alpha the measure of amphetamine-induced dopamine release with SPECT in nonhuman primates. Microdialysis experiments
of dialysate dopamine content Dopamine levels in microdialysis samples were analyzed by standard high). For microdialysis studies, dialysate dopamine levels (pg/ml) in each 15-min sample were transformed to percentage and homotaurine on ethanol- stimulated mesolimbic dopamine release Basal ...
Dopamine release from tuberoinfundibular dopamine neurons into the median eminence activates dopamine-D2 receptors in the pituitary gland where it inhibits lactotroph function. We have previously described genetic dopamine-deficient mouse models which lack the ability to synthesize ...
Technology Transfer Automated Retrieval System (TEKTRAN)
Dopamine transport currents are promoted from curiosity to physiology David Sulzer1 and Aurelio with behavioral reward. Dopamine released during bursts feeds back onto D2 autoreceptors that depress neuronal these neurons by activating an uncoupled Cl---- conductance that is mediated by the dopamine uptake ...
Individuals are known to differ in their sensitivity to cocaine. Cocaine is known to inhibit the re-uptake of monoamines. The response to cocaine has also been found to depend on monoamines inside reserpine-sensitive storage vesicles. The present study examined the effects of reserpine (1-2 mg/kg) on cocaine-induced behavior (10-15 mg/kg) in Low Responders (LR) and High Responders (HR) to novelty ...
Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments
Ecstasy is a dangerous drug that causes the release of serotonin, dopamine, norepinephrine, and acetylcholine. These molecules are neurotransmitters.
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