Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the ...

... Title : Interrelationship of Histamine Release and Vasoactive Peptides. ... Abstract : Peptides release histamine from mast cells. ...

Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine ...

Mast cells release histamine when an allergen is encountered. The histamine response can produce sneezing, itching, hives and watery eyes.

... Title : Release of Histamine from Mast Cells by Vasoactive Peptides. ... Des-arginine derivatives of bradykinin did not release histamine. ...

... Accession Number : AD0255745. Title : STUDIES ON THE KINETICS OF HISTAMINE RELEASE FROM NORMAL AND SENSITIZED TISSUES. ...

... Accession Number : AD0779410. Title : Functional Role of Hypothalamic Histamine: Release of Vasopressin. Descriptive Note : Technical rept. ...

Immunological release of histamine from the whole blood of the sensitized chickens was demonstrated. Compound 48/80 (a potent histamine releaser) released histamine from isolated chicken lung. The sensitizing antigens (bovine albumin or horse plasma) did not ...

... histamine catabolism. Histamine concentrations increased from 26 + or - 13.5 to 235 + or - 16 ng/ml after irradiation. When ...

not induce histamine release or activation of basophils as demonstrated by FACS analysis of CD203c expression and by histamine release experiments. In vivo skin testing confirmed the lack of allergenic activity of the Sc to the fast release of inflammatory mediators (e.g., ...

The hemolytic activities of clinical isolates of Serratia marcescens, of Serratia liquefaciens, and of Escherichia coli strains containing a cloned hemolysin gene of S. marcescens were determined. Hemolysis was induced only by cells and not by spent media. The hemolytically active bacteria induced the release of the leukotriene C4 and of much less leukotriene B4 from ...

Histamine receptors are present in adrenergic terminals, and histamine is reported to inhibit release of the neurotransmitter norepinephrine (NE) at certain neuroeffector junctions. However, a physiological role for histamine in modifying adrenergic neuro...

... sub 1. Results showed that PGE sub 1 caused release of granules, of histamine (indicated by release of H3-histamine), and of heparin (shown by ...

... Accession Number : ADP008324. Title : Effect on Histamine Release by LHRH Antagonists Featuring Translocation of the Cationic Amino Acid,. ...

Our previous study demonstrated the co-localization of histamine with norepinephrine (NE) within superior cervical ganglia (SCG), and the release of histamine from sympathetic nerve endings of guinea pig evoked by stimulations. We have now further investigated that whether the histamine can be synthesized, stored ...

Histamine release by compound 48/80 was studied in vivo and in vitro in different tissues of the cat and rat. A good correlation was fond between both kinds of experiment. The histamine stores in the cat salivary gland are poorly sensitive to this histamine-liberating substance. In vitro studies with heart and ...

The theory of histamine release of Dembo, Goldstein, Sobotka, and Lichtenstein is able to explain a variety of kinetic experiments in a self consistent and quantitative way. The principal elements of the theory are: the histamine content of basophils is d...

Incubated mixtures of Mycoplasma salivarium and nonsensitized mixed leukocytes released histamine. Spectrophotofluorometric detection of histamine occurred at physiological temperature and pH independent of complement and specific antiserum.

The results obtained with 24 rabbits show a definite correlation between antigen induced histamine release from rabbit platelets and PCA antibody production. In all cases where there was PCA antibody production there was also antigen induced histamine rel...

The role of histamine in acid secretion is controversial. Improvements in the techniques of histamine assay allow a better assessment of the relationship of histamine to acid secretion. Patients with duodenal ulcers were studied to determine the mucosal histamine responses to pentagastrin stimulation to relate the ...

The antigen-induced, IgE-dependent release of chemical mediators from human lung tissue in vitro is modulated by a variety of pharmacologic maneuvers involving alterations in the intracellular levels of cyclic nucleotides. Increase in the level of cyclic AMP inhibits the immunologic release of histamine, SRS-A and ECF-A; ?-adrenergic ...

... (Author). Descriptors : (*CS AGENTS, *PAIN), (*IRRITATING AGENTS, PAIN), BLOOD PLASMA, HISTAMINE, PERITONEUM. ...

... 62 3. HISTAMINE RELEASE FROM IN VITRO SENSITIZED ATRIA AS A FUNCTION OF ANTIBODY CONCENTRATION ..... 72 ...

... may cause an anaphylactoid reaction on first exposure. Histamines and other substances released into the bloodstream cause ...

Our previous studies have shown that histamine existed widely in the sympathetic nervous system and functioned differentially on the sympathetic nerve activation level. Therefore, in this study, we tried to find out whether it is the special exocytosis/recycling of histamine-containing vesicles that contribute to those differential ...

Histamine is the principal mediator released in the skin during immediate bee venom allergy but the significance of cysteinyl leukotrienes in these reactions is not known. We measured skin histamine and cysteinyl leukotriene release induced by bee venom in six sensitized beekeepers with the skin microdialysis ...

Pasteurella haemolytica A1 leukotoxic culture supernatant was evaluated for its ability to induce histamine release from bovine pulmonary mast cells isolated by enzymatic dispersion of lung tissue. Histamine was measured by a radioimmunoassay technique. Leukotoxic culture supernatant of P. haemolytica significantly ...

Beta-mercaptoethylamine-induced hypotension is associated, in a statistically significant way, with increased circulating histamine. The histamine levels are quite variable and failure to find increased levels in some animals does occur. The hypotension p...

MOLECULAR REPRODUCTION AND DEVELOPMENT 73:1550�1563 (2006) The Histamine H1 Receptor Activates for histamine (suH1R) on the egg cell surface that activates NO production. Treatment with histamine (HA) causes-Liss, Inc. Key Words: histamine receptor; nitric oxide; cal- cium release; ...

Ethacrynic acid, a known inhibitor of both Na+--K+ and Mg2+-activated ATPases, effectively inhibits histamine release from antigen-challenged human basophils in vitro. Ouabain, an inhibitor specific for Na+--K+-activated ATPases, shows no effect upon the quantity of histamine released from the antigen-challenged ...

1 Corticosteroids are known to suppress evoked histamine release from human skin in vitro. Therefore the effect of prednisone, on cold evoked histamine release and clinical response was studied in six patients with acquired cold urticaria. 2 Following cold challenge all six patients developed an immediate ...

1. Histamine secretion from rat mast cells occurs in the presence of nanomolar concentrations of acetylcholine. 2. Intact glycolytic and oxidative metabolism is required for the acetylcholine-induced histamine secretion. Removal of extracellular glucose, hypoxia, cyanide and monoiodoacetate almost completely inhibit the secretion. 3. The secretion of ...

Effector memory T helper 2 (Th2) cells that accumulate in target organs (i.e. skin or bronchial mucosa) have a central role in the pathogenesis of allergic disorders. To date, the factors that selectively trigger local production of Th2-attracting chemokines remain poorly understood. In mucosa, at the sites of allergen entry, immature dendritic cells (DC) are in close contact ...

Effector memory T helper 2 (Th2) cells that accumulate in target organs (i.e. skin or bronchial mucosa) have a central role in the pathogenesis of allergic disorders. To date, the factors that selectively trigger local production of Th2-attracting chemokines remain poorly understood. In mucosa, at the sites of allergen entry, immature dendritic cells (DC) are in close contact ...

The release of histamine in guinea pig lungs after inhalation of 1 to 50 ppM SO/sub 2/, 10 ppM NO/sub 2/, or cigarette smoke was minimal in terms of the amount released spontaneously. Histamine release was not significant until concentrations caused severe lung damage.

mediators. Some histamine H1 receptor antagonists exert anti- inflammatory activities by modulating mediator receptor antagonist, on the release of eicosanoids, histamine and IL-4 from human basophils and lung mast release from lung mast cells. In contrast, mizolastine enhanced up to 80% IgE- mediated ...

November 1994; accepted 17 May 1995 Molecular Identification of an IgE-Dependent Histamine-Releasing Factor (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children proteins caused histamine release from the human basophils of a subpopulation ofdonors, and this ...

Thymopoietin peptides release histamine and serotonin from rat mast cells. The release has the characteristics of other basic secretagogues in that it occurs rapidly, does not require extracellular Ca2+ ions, and is inhibited by benzalkonium chloride (BAC). These similarities indicate that chemically different basic compounds have ...

The accumulation of dust, proteins and allergens from alder, birch, timothy, cat, dog, mite, hen egg white, codfish and mould in schools was investigated by analysing the content of vacuum cleaners after 10 days of use. The main goals were to compare the dust accumulation on carpeted and smooth floors and to estimate to what degree the three vacuum cleaner ...

We investigate certain general properties of antigen induced degranulation of sensitized basophils by analyzing two types of experiments: experiments in which we expose basophils to two antigens seuquentially and then determine the fraction of histamine released; and experiments in which we obtain time-dependent release and ...

Following the injection of histamine directly into the supraoptic nucleus, a dramatic decrease in urine flow ensued. This oliguria, and the concomitant increase in urine concentration, reflect the release of vasopressin. This histaminergic effect could be...

Angioedema constitutes an important clinical problem that can cause significant morbidity and mortality. Correct management requires a prompt recognition and treatment of the acute event and identification of the underlying cause. Many cases are caused by non-allergic reactions and do not result from mediator release by degranulating mast cells and basophils, but are related ...

... Abstract : The iv injection of pethidine can bring about allergic phenomena due to the endogenous release of histamine. ...

It may be that a substance from polymorphonuclear leucocytes attacks mast cells and releases histamine into the area of inflammation

+ +/- ++ - - +++ - - d e Binds to Fc receptors on macrophages/ NK cells ++ +/- ++ + - + - - f Histamine release from Mast

Hives develop when histamine is released into the small blood vessels (capillaries). The capillaries dilate which causes ...

Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be ...

1319 ... www.nlm.nih.gov ... Dermatographism is a condition where lightly scratching the skin raises wheals or welts. Histamine is released ...

-induced Histamine Release by Human Mast Cells and Basophils Sun W. Tam1,2,4 , Sossiena Demissie 1 , David Thomas1 the release of histamine by IgE-sensitized cells, but it also prevented specific antigen from triggering histamine release. Comparable inhibitions were ...

We describe the characteristics of in vitro histamine release from human basophils passively sensitized with serum from a penicillin-allergic individual. The histamine release is induced by a synthetic bivalent hapten, bis benzylpenicilloyl 1,6 diaminohexane (BPO)/sub 2/. We present data on the effect of a ...

The 5-lipoxygenase inhibitor Phenidone inhibits the antigen-induced release of histamine from human basophiles at concentrations of 10(-4) up to 10(-5) mol/l. These findings indicate once more that products of the arachidonic acid metabolism are involved in the induction of histamine release from human basophiles. ...

The mite antigen-induced histamine release from leucocytes of chronic urticarial patients was enhanced in the presence of deuterium oxide, which stabilizes microtubules. This enhancing effect of deuterium oxide on the histamine release from leucocytes may provide a useful means for the detection of allergens in ...

The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic ...

L-Histidine, when tested at a 10-mM concentration, caused a rapid and sustained stimulation of insulin release from rat islets exposed to either D-glucose (7.0 or 8.3 mM) or L-leucine (10.0 mM). The stimulation of insulin release could not be ascribed to an increase in oxygen uptake, to the generation of histamine from L-histidine, or ...

Changes in blood histamine concentrations of rhesus monkeys were measured after a 4000-rad dose of mixed gamma-neutron radiation. All animals were pretreated with amino-guanidine to retard histamine catabolism. Histamine concentrations increased from 26 +...

such as histamine, seroto- nin, serine proteases, exopeptidases, and neuropep- tides (Stevens and Austen, 1989 of precocious puberty. Such treatment induced histamine secretion from mast cells, leading to cutaneous:16�24. Manning KA, Pienkowski TP, Uhlrich DJ. 1994. Histamin- ergic and ...

Most cytokines possess multiple biologic activities. This study was undertaken to investigate the effect of rIL-1 beta, -2, -3, -4 and -6, IFN-gamma, TNF-alpha, and granulocyte-macrophage (GM)-CSF on basophils from 16 donors and the amount of histamine released was compared with that by partially purified mononuclear cell-derived ...

Granulocyte�macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are recognized as enhancers, but not as inducers, of histamine release from normal human basophils. However, when extracellular Na⁺ is removed IL-3 acquires the capacity to induce histamine release. The aim ...

BackgroundIt has been recognized that phospholipase A₂ (PLA₂) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA₂ provoke inflammation remain unclear. Recently, a N49 PLA₂, TM-N49 from Protobothrops ...

The problem of a preoperative histamine H1- + H2 - prophylaxis was tackled by a group of new studies including randomized controlled clinical trials and cross-sectional studies with plasma histamine measurements and administration of H1- + H2 - antagonists to a control group. The first study demonstrated serial histamine ...

The effect of substance P and compound 48/80 on histamine and serotonin release from not isolated and isolated mast cells have been compared in experiments in vitro. The response of not isolated and isolated mast cells were virtually identical. The release of both amines, in response to 48/80 and substance P, was dose-dependent. The ...

1. The chloroplatinate ion can release histamine from the tissues in various species of animals. 2. This property is not shared by other complex ions with co-ordination number 6, or other complex platinum ions. 3. The release of histamine may form the basis of the known disease platinosis which affects people who ...

Adverse reactions to roentgenographic contrast media (RCM) are associated with the release of mediators including complement components (anaphylatoxins), histamine and serotonin. In an in vitro study of platelets and leukocytes from 20 healthy individuals, RCM-induced release of granules from basophils and platelets was correlated with ...

We investigated the role of 27 disease-relevant Escherichia coli strains isolated from humans in the induction of histamine release from rat peritoneal mast cells and human basophilic granulocytes. Our data indicated that only the hemolysin-positive (HLY+) bacteria and the hemolysin-positive culture supernatants induced histamine ...

Evans, Elizabeth and Nicholls, P. J. (1974).British Journal of Industrial Medicine,31, 28-30. Histamine release by Western red cedar(Thuja plicata)from lung tissue in vitro. Various respiratory symptoms have previously been observed in workers exposed to dust from Western red cedar (Thuja plicata). Although an allergic basis for these effects has been ...

Histamine was found to be stored in the submandibular gland of the cat mainly in the mast cells. The amine is released from mast cells by compound 48/80 and pilocarpine. This was demonstrated in the in vivo and in vitro experiments and by histological examination. During the physiological stimulation of the gland, via the electrical stimulation of the ...

Histamine activates pain-transmitting nerve fibres, releases pain-related neuropeptides, and is painful when injected into the skin. Histamine agonists mimic these effects, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus. Certain ...

In a controlled clinical trial in patients admitted for general surgery (mainly abdominal and thyroid), histamine release following nalbuphine 1 mg/kg i.v. versus fentanyl 5 micrograms/kg i.v. was studied in the course of an otherwise routine induction with promethazine/pethidine as premedication 30 min before the opioids and ...

Histamine, beta-adrenergic amines, and prostaglandins inhibited hemolytic plaque formation by splenic leukocytes from immunized mice. The same agents had previously been shown to prevent both the IgE-mediated release of histamine from human basophils and the immunologically specific cytolytic activity of murine lymphocytes, through ...

was isolated from the skin secretions of the dusky gopher frog (Rana sevosa) on the basis of histamine release actions. � 2004 Elsevier Inc. All rights reserved. Keywords: Granulopoiesis; Histamine; HPLC; Peptidomics frogs and the release of histamine from rat Corresponding author. Tel.: +44 ...

Da portion of the allergen. Histamine release assays with single crystal solutions using basophils). Histamine Release Assay--20 ml of fresh blood (in 10 mM EDTA) from a grass pollen-allergic patient were antibody Bo1) using the full-length allergen as a calibration standard. Histamine concen- ...

Metastases continue to be the chief cause of morbidity and mortality for many tumors, including brain metastases of lung and mammary adenocarcinoma. Stress appears to increase metastases, but the mechanism is not understood. Recent evidence suggests that local inflammation is conducive for cancer growth and a unique immune cell, the mast cell, accumulates in the stroma ...

Histamine is biogenic amine that exerts the numerous important biological functions. Alcohol affect histamine action because those have common metabolizing enzymes--aldehyde dehydrogenase and aldehyde oxidase. Acetaldehyde can compete with aldehydes derived from histamine metabolism. Increased blood acetaldehyde resulting from ...

Cultured human endothelial cells synthesize prostacyclin (PGI2), a potent inhibitor of platelet function, when stimulated with histamine, bradykinin, or ATP. Paradoxically, we report that these agonists also induced the rapid and sustained synthesis of platelet-activating factor (PAF) by endothelial cells. In fact, the synthesis of this potent activator of platelets and ...

Rat peritoneal mast cells were incubated with serum from highly mite-sensitive patients. It was demonstrated that exposure of passive sensitized mast cells to allergen from mites Dermatophagoides farinae induced the release of histamine. Exposure of mast cells to 10 micrograms/ml and 50 micrograms/ml mite allergen resulted in an increase of ...

Acute ultraviolet light B (UVB) injury is associated with dermal mast cell histamine release. The possibility that histamine-stimulated prostaglandin (PG) synthesis could be a mechanism for irradiation erythema was therefore examined using human skin explants. Explants responded to UV irradiation (120 mJ/cm2) with a fivefold increase ...

We have previously purified and partially characterized histamine releasing factors (HRF), which were derived from a mixture of human mononuclear cells and platelets. We now report the effect of IL-8 upon HRF-, connective tissue activating peptide III (CTAP III)-, and IL-3-induced histamine release from human ...

A study was performed about the effects of increasing concentrations of muscle relaxants (suxamethonium, d-tubocurarine, vecuronium, and atracurium), hypnotics (propofol, ketamine, and thiopental), opioids (morphine, buprenorphine, and fentanyl), and benzodiazepines (diazepam, flunitrazepam, and midazolam) on the release of preformed (histamine and ...

1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These ...

Previous studies on histamine release by corticotropin peptides and melittin peptides were extended, leading to the identification of a synthetic peptide intermediate, Lys(Z)-Arg(NO2)-Arg(NO2)OMe, (I) as an active non-cytolytic histamine releaser from rat mast cells. However, significant differences in the ...

Earlier experiments suggested that the action of muscarinic agonists in gastric acid secretion might be partly mediated by endogenous histamine release. This possibility could be tested by use of various calcium antagonists provided that they show different activity on histamine- and carbachol-induced secretion. In the present work, ...

A radioenzymatic assay for the measurement of histamine is described, based on the incubation of histamine in the presence of histamine-N-methyl-transferase from rat kidney and (/sup 3/H-methyl)-S-adenosyl-L-methionine (sp act 15 Ci/mmol) in phosphate buffer, 0.05 mole/l, pH 7.9, at 37/sup 0/C for 60 min. The N-(/sup ...

Drugs interfering with the histaminergic system facilitate behavioral recovery after vestibular lesion, likely by increasing histamine turnover and release. The effects of betahistine (structural analogue of histamine) on the histaminergic system were tested by quantifying messenger RNA for histidine decarboxylase (enzyme synthesizing ...

Histamine release in the rat was induced in vivo either by a single dose of compound 48/80 injected i.v. or by four repeated, daily doses of the same compound injected i.p. After i.v. injection the levels of blood histamine were determined and after i.p. injections the changes in both tele-methylhistamine and ...

Cerebral ischemia induces excess release of glutamate and an increase in the intracellular Ca(2+) concentration in neurons, which provokes enzymatic process leading to irreversible neuronal injury. Histamine plays a role as a neurotransmitter in the mammalian brain, and histamine release from nerve endings is ...

Histamine is a bioactive amine that exerts immunomodulatory functions, including many allergic symptoms. It is preformed and stored in mast cells and basophils but recent evidence suggests that other cell types produce histamine in an inducible fashion. During infection, it has been suggested that neutrophils may produce histamine. We ...

The effect of selective histamine H3-receptor agonists and antagonists on the acetylcholine release from peripheral nerves was evaluated in the guinea pig longitudinal muscle-myenteric plexus preparations, preloaded with ({sup 3}H)choline. In the presence of H1 and H2 blockade, histamine and (R)-{alpha}-methylhistamine inhibited the ...

Cardiotonic glycosides modify histamine secretion from rat mast cells in the following way. (1) Preincubation (30 min) of mast cells with liposoluble glycosides (10(-4) mol/l) increases the spontaneous histamine secretion by about 5%. (2) Preincubation of mast cells with 10(-4) mol/l liposoluble glycosides (digitoxin, digoxin, digitoxigenine) decreases ...

Antigen-induced, IgE-mediated release of histamine from human basophiles is an in vitro model of allergic reacttions; it is blocked by extracellular histamine, presumably as a result of its ability to increase adenosine 3',5'-monophosphate (cyclic AMP) levels. The H1 antihistamines do not antagonize these effects of ...

The recently developed sensitive, automated histamine assay system was applied for in vitro allergy testing. The simplified method for histamine release from whole heparinized blood was used. Aliquots of blood and allergen were incubated for one hour at 37 degrees C, and each supernatant was then analyzed for ...

The effects of Inosine pranobex and its parent compounds inosine and dimethylamino-2-propanol-p-acetamidobenzoic acid (DipPacBa) on the Concanavalin A (ConA)-induced histamine release from human adenoidal mast cells were investigated. Inosine pranobex inhibited the ConA-induced histamine release at concentrations ...

The relationship between the intensity of the signal for antigen-induced immunoglobulin E-mediated histamine release from human basophils and the concentration of agonist needed to inhibit release has been determined. The agonists, prostaglandin E1, dimaprit, fenoterol, isobutylmethylxanthine and dibutyryl cyclic AMP, all act by ...

To detect low levels of histamine, we developed a histamine microsensor using recombinant histamine oxidase. Histamine oxidase with a histidine tag was readily purified using a histidine affinity column. The enzyme showed higher catalytic activity on histamine than diamines (e.g., putrescine ...

1. The effects of histamine and agents at histamine receptors on spontaneous and 100 mM K(+)-evoked release of acetylcholine, measured by microdialysis from the cortex of freely moving, rats, and on cognitive tests are described. 2. Local administration of histamine (0.1-100 microM) failed to affect spontaneous but ...

Modafinil is a drug used to treat hypersomnolence of narcolepsy. We previously reported that modafinil increases hypothalamic histamine release in rats but did not increase locomotor activity in histamine-depleted mice, suggesting that modafinil-induced locomotor activity involves the histaminergic system. Modafinil is also thought to ...

Intracutaneous injection of the low molecular weight fragment (C3a) of the third component of human complement caused pruritus, wheal and axon-reflex erythema in human skin. The response was maximal at 5�10 min after injection and dose-dependent between 15 and 600 ng. On a molar basis, C3a was more effective than histamine. The response to C3 anaphylatoxin required the ...

We investigated the interaction between ambient histamine and acetylcholine by studying ? oscillations in rat hippocampus, induced by bath application of acetylcholine (10 �M combined with 2 �M physostigmine). The power of ? was significantly increased by the H1 antagonist, fexofenadine, and H2 receptor agonist, dimaprit, and reduced by the H2 receptor antagonist, ...

,31). This effect has been attributed to the release of gastric mucosal histamine in direct response to the activation of peripheral histamine receptors. Taken together, these studies suggest that part of the rat mediated by peripheral histamine (16), and homeostatic mechanisms responding to cellular and ...

did not affect NO release but reduced Ca2 responses to thrombin and histamine, suggesting cross of ERK1/2 cascade (8). In addition, the GPCR activators thrombin and histamine inhibit the EGF NO and Ca2 responses to thrombin or to histamine after a previous stimulation with the mutant thrombin S195A

less than those of the control mice. Furthermore, the rise in serum histamine in the mice fed with CS-linking of IgE with newly absorbed allergens, and release of chemical mediators such as histamine and leu symptoms. Several drugs, such as corticosteroids, epinephrine, histamine antago- nists, and leukotriene

, allowing for very fast release (e.g., serotonin, histamine) (10, 14, 15). Due to their ability to migrate established that brain mast cells contribute to the neural pool of histamine (32�34). To confirm mast cell contribution to brain anime levels, we measured histamine in whole brain homog- enates. Sash / mice ...

-- histamine, acetylcholine and ATP. By empirically matching concentrations, we found that all three agonists responded to histamine and then subsequently to ATP. The similarity in spatial organisation of the elementary Ca2+ signals evoked by histamine or ATP is apparent in the line scans (Figure 1b) and the surface

]GSK189254 Synonym: Agent Category: compound Target: Histamine H3 receptor Target Category: Receptor MethodMed] Histamine mediates its activity in the central nervous system (CNS) and the peripheral tissue through four G to regulate the synthesis and release of histamine itself and other neurotransmitters such as ...

The methanol extract of wax gourd (Japanese name "Tougan"), the fruits of Benincasa hispida COGN. (Cucurbitaceae), was found to show inhibitory activity on the histamine release from rat exudate cells induced by antigen-antibody reaction. Through bioassay-guided separation, four known triterpenes and two known sterols were isolated as active components ...