... These features are correlated with histology from the same location in the prostate to determine which feature combinations accurately predict the ...

The ability to predict a pion dose distribution in a patient is a major objective of the clinical trials at LAMPF. Accurate predictions are essential for evaluation of pion therapy. But accuracy must be in the context of clinical utility. That is, reasona...

An accurate method of predicting the date of parturition in the bitch is clinically useful to minimize or prevent reproductive losses by timely intervention. Similarly, an accurate method of timing canine ovulation and gestation is critical for development of assisted reproductive technologies, e.g. estrous ...

Dr. Triche's program focuses on refining and validating molecular signatures that provide a more accurate diagnosis of the common childhood sarcomas and signatures that more accurately predict clinical behavior of these tumors. The project will build on signatures developed during the Director's Challenge program.

We examined the ability of clinicians to predict the causative organism of bovine mastitis in our practice. We obtained 118 milk culture results from 112 mastitic cows and compared the culture results to the predictions of clinicians at the time of milk sample collection. Sixty of 118 culture results were accurately ...

We examined the ability of clinicians to predict the causative organism of bovine mastitis in our practice. We obtained 118 milk culture results from 112 mastitic cows and compared the culture results to the predictions of clinicians at the time of milk sample collection. Sixty of 118 culture results were accurately ...

... Title : A METHODOLOGY FOR ACCURATELY PREDICTING DEMAND FOR AIRLIFT OF MILITARY CARGO TO OVERSEAS DESTINATIONS,. ...

Our goal is to develop a new in vitro model of human prostate cancer. Available models do not faithfully replicate prostate cancer in situ and therefore activities of experimental drugs in these models do not accurately predict clinical efficacy. We are d...

The ability to predict a pion dose distribution in a patient is a major objective of the clinical trials at LAMPF. Accurate predictions are essential for evaluation of pion therapy. But accuracy must be in the context of clinical utility. That is, reasonable approximations must be made in ...

SummaryProstate cancer is a very complex disease, and the decision-making process requires the clinician to balance clinical benefits, life expectancy, comorbidities, and potential treatment related side effects. Accurate prediction of clinical outcomes may help in the difficult process of making decisions related ...

It is clear that external vibroacoustic stimulation with the EAL produces remarkable changes in FHR and fetal movement patterns that are related to changes in fetal behavior. The clinical significance of these studies has been addressed in small series on human fetuses by many authors. There is an obvious lack of uniformity in the different protocols used to determine the ...

... Title : Fast and Accurate Prediction of Windborne Contaminant Plumes for Civil Defense in Cities. Descriptive Note : Conference paper. ...

... Accession Number : ADD200835. Title : An Accurate Prediction of Natural Frequencies of Laminated Plates by a Higher Order Theory. ...

Accurate risk assessment is of paramount importance to newly diagnosed prostate cancer patients and their physicians. Risk prediction models help identify those at high (or low) risk of disease progression and guide discussions about prognosis and treatment. Widely used, well-validated prediction tools are based on standard, readily ...

Epidemiological studies indicate an increased risk of subsequent primary ovarian cancer from women with breast cancer. We have recently identified a 28-gene expression signature that predicts, with high accuracy, the clinical course in a large population of breast cancer patients. This prognostic gene signature also accurately ...

Pulmonary embolism is a common and potentially lethal disease. Given the variable presentation and associated morbidity of this condition, an accurate and efficient diagnostic algorithm is required. Clinical pretest probability serves as the root of any diagnostic approach. We, thus, review several clinical decision rules that may help ...

This paper shows that cost justification for bedside clinical computing can be made by recouping charges with accurate charge capture. Twelve months worth of professional charges for a sixteen bed surgical intensive care unit are computed from charted data in a bedside clinical database and are compared to the professional charges ...

External supervoltage radiation is now an accepted form of treatment for adenocarcinoma of the prostate but the tumor response cannot be predicted. We hope in the future that accurate clinical staging coupled with a biological staging of the tumor cells with catalase activity will enable us to predict this ...

Patients were referred to the Department of Nuclear Medicine for brain scintigraphy to be screened for possible intracranial pathology. These referrals were made in order to reduce the heavy load on the transmission computerized tomography (TCT) facilities. Great clinical importance, therefore, has been attached to scintigraphic findings; this emphasizes the need for an ...

The analysis of receptors for oestrogen in early cancer of the breast may be used to predict prognosis. The presence or absence of oestrogen receptors is independent of menstrual status, the stage of the patient's disease, and the histological grade of the tumour. Therefore combination with other prognostic factors gives a more accurate assessment of an ...

Quantitative testing of a patient's basal pain perception before surgery has the potential to be of clinical value if it can accurately predict the magnitude of pain and requirement of analgesics after surgery. This review includes 14 studies that have investigated the correlation between preoperative responses to experimental pain ...

The key to weather prediction lies in accurately measuring these variables and feeding the data into numerical models that can predict changes in the ...

Sustainable delivery of quality healthcare at affordable cost is a major challenge, especially in oncology. Through interdisciplinary collaboration, researchers can provide new insights into familiar concepts and radically change the ways in which biopharmaceutical and medical studies are conducted and translated into clinical practice. One interdisciplinary approach is ...

We carried out a genotype-phenotype correlation study, based on clinical findings in 465 patients with myotonic dystrophy (DM), in order to assess [CTG] repeat number as a predictive test of disease severity. Our analysis showed that the DM subtypes defined by strict clinical criteria fall into three different classes with a log-normal ...

Colorectal cancer (CRC) treatment has evolved significantly over the last ten years with the use of active chemotherapeutic agents including fluoropyrimidines, oxaliplatin and irinotecan plus targeted monoclonal antibodies bevacizumab, cetuximab and panitumumab. The addition of newer chemotherapeutic agents and targeted therapies has improved patient outcomes at the cost of increased toxicity with ...

BackgroundBiologic predictors or biomarkers of survival in pulmonary fibrosis with a worse prognosis, more specifically in idiopathic pulmonary fibrosis would help the clinician in deciding whether or not to treat since treatment carries a potential risk for adverse events. These decisions are made easier if accurate and objective measurements of the patients' ...

The clinical features at presentation of 53 patients admitted with primary acute pancreatitis due to gall stones were compared with those of 31 patients in whom the disease was due to other causes. Between these two groups 10 significant differences existed. By listing the frequency of symptoms and signs for each group a computer data base was prepared and incorporated into a ...

Attempts to predict survival in patients with renal cell carcinoma (RCC) have traditionally relied on standard clinical variables, such as tumor-node-metastasis stage, histologic grade, and performance status. An accurate method for predicting patient survival is useful for patient counseling, planning follow-up, ...

PurposeThere are established differences in breast cancer epidemiology between Asian and white individuals, but little is known about hereditary breast cancer in Asian populations. Although increasing numbers of Asian individuals are clinically tested for BRCA1/2 mutations, it is not known whether computer models that predict mutations work ...

Study design:A retrospective analysis.Objectives:The objective of this study is to determine whether dipstick protein analysis (DSP) or random urine protein:creatinine ratios (UPC) are accurate in predicting clinical proteinuria in the chronic spinal cord injury (SCI) population.Methods:A retrospective analysis was performed in 219 ...

An algorithm was developed to predict lymph node metastasis in patients with oral squamous cell carcinoma. To improve the diagnostic accuracy of lymph node status, we suggest a criterion for the prediction of lymph node status by combining clinical and molecular information. To develop a model to predict lymph node ...

The application of laser welding technology allows titanium to be welded predictably and precisely to achieve accurate fit of a milled framework. Laser energy results in localized heat production, thereby reducing thermal expansion. Unlike soldering, laser energy can be directed to a small area, making it possible to laser weld close to acrylic resin or ...

... Title: An Efficient and Accurate Method of Estimating Substrate ... This thesis presents a Z-parameter based model to predict the substrate ...

A model for the cardiovascular and circulatory systems has previously been validated in simulated cardiac and circulatory disease states. It has also been shown to accurately capture the main hemodynamic trends in porcine models of pulmonary embolism and PEEP (positive end-expiratory pressure) titrations at different volemic levels. In this research, the existing model and ...

Accurate identification of hypertension is crucial for the prevention of cardiovascular disease. Home blood pressure monitoring (HBPM) provides superior prediction of cardiovascular disease, compared with clinic pressures. HBPM can be a valuable resource for the effective treatment of hypertension, when combined with other modalities ...

Non-mydriatic retinal photography with later interpretation of the photographs was assessed as a screening method for the detection of diabetic retinopathy; when compared with an ophthalmologist's clinical assessment in a random group of 62 diabetic patients it was accurate (false negative 6.8%, false positive 2%) and sensitive (sensitivity 96%, ...

Since its introduction into the clinical environment in the early nineties, the cardiac enzyme troponin has significantly changed the way we diagnose and manage acute coronary syndromes. Troponin I is a biochemical marker of myocardial injury with a high level of specificity and sensitivity. It has been demonstrated that as ischaemia progresses, troponin I is degraded ...

Mammography is an ideal time to assess risk of breast cancer because breast density, one of the strongest risk factors for breast cancer, can be assessed from the patient's mammogram. Clinical risk factors are already assessed at the time of mammography. The combination of a qualitative measure of breast density and risk factors estimates a patient's risk of breast cancer more ...

Kote-Jarai,Z. Matthews,L. Osorio,A. Shanley,S. Giddings,I. ...

Pancreatic adenocarcinoma is a deadly disease with few effective therapeutic options. Surgical resection of early stage disease offers the only possibility of long-term survival. The overall care of patients with localized pancreatic cancers would be greatly aided by methods that accurately predict the clinical course of patients ...

A review of the literature was done to determine the number of studies published on the osmol gap. We wanted to examine whether these studies were able to establish a consensus on the formula to be used, the appropriate reference interval to be used and finally the performance of the osmol gap in its ability as a screening test for toxic volatile substance. Our study was disappointing since no ...

To avoid toxicity and expense, improved tools for selecting individual patients for treatments and accurate prediction of who will respond and who will not respond to treatment are needed. Although new technologies for genomic profiling have been developed, none has made it into clinical practice because it is difficult to develop ...

BackgroundEndometrial carcinoma is the most distressing cause of abnormal vaginal bleeding. The intention of clinical management in the case of postmenopausal bleeding is to achieve an accurate diagnosis without overinvestigation.MethodWe studied the available literature on the diagnostic evaluation of postmenopausal women with vaginal bleeding, ...

The number of no-shows has a significant impact on the revenue, cost and resource utilization for almost all healthcare systems. In this study we develop a hybrid probabilistic model based on logistic regression and empirical Bayesian inference to predict the probability of no-shows in real time using both general patient social and demographic information and individual ...

Introduction Accurate estimates of risk are essential for physicians if they are to recommend a specific management to patients with bladder cancer. In this review, we discuss the criteria for the evaluation of nomograms and review current available nomograms for advanced bladder cancer.Methods A ...

Accurate estimation of survival is important for effective palliative medicine of patients with cancer. In most clinical practice, however, the life expectancy has been predicted based on subjective evaluations. The purpose of this study was to find objective biological markers that can contribute to accurate ...

Magnetic resonance image (MRI) has provided an imageological support into the clinical diagnosis and prediction of Alzheimer disease (AD) progress. Currently, the clinical use of MRI data on AD diagnosis is qualitative via visual inspection and less accurate. To provide assistance to physicians in improving the ...

The determination of myocardial viability is a crucial parameter in the evaluation of a patient with coronary artery disease. Particulate myocardial perfusion scintigraphy (PMPS) is one of several methods available for this determination. A brief comparison between PMPS and two other commonly used methods is described in this review. The technique and analysis are described and applied to 194 ...

Accurate staging of lung cancer is necessary to describe and communicate disease extent, predict prognosis, determine therapy, and evaluate the results of clinical trials. The Union Internationale Contre le Cancer and the American Joint Committee on Cancer published the seventh edition of tumor, node, and metastasis in lung cancer in ...

The prevalence of malnutrition among critically ill patients, especially those with a protracted clinical course, has remained largely unchanged over the last two decades. The metabolic response to stress, injury, surgery, or inflammation cannot be accurately predicted and these metabolic alterations may change during the course of ...

One hundred seventeen patients with clinical signs and symptoms of transient ischemic attacks (TIAs) were evaluated. All underwent clinical evaluation for bruit, ophthalmodynamometry, rapid sequence scintiphotography with rectilinear scanning and four-vessel cerebral angiography. The results of these tests were compared for reliability in ...

Artificial neural network (ANN) modeling was used to evaluate the pharmacokinetics of aminoglycosides (arbekacin sulfate and amikacin sulfate) in severely ill patients. The plasma level was predicted by ANN modeling using parameters related to the severity of the patient's condition and the predictive performance was shown to be better than could be ...

To gain regulatory approval for a new medicine, a pharmaceutical company must take the new product through a series of clinical trials (Phases I-III). Animal models are important in the new drug-development process because they allow for the testing of the efficacy and safety of potential new medicines in a cost-efficient manner that avoids the risk of serious adverse events ...

The advent of microarray-based gene-expression profiling a decade ago raised high expectations for rapid advances in breast cancer classification, prognostication and prediction. Despite the development of molecular classifications, and prognostic and predictive gene-expression signatures, microarray-based studies have not yielded definitive answers to ...

To detail the clinical presentation of oral epithelial dysplasia in a large cohort of residents in western Europe. Descriptive statistical analysis of the data were calculated using chi-square and Fisher's exact tests. Oral epithelial dysplasia manifested typically as a white or mixed red and white lesion on the tongue, buccal mucosa or floor of mouth. The peak age of ...

Accurately assessing cancer risk in average- and high-risk individuals and determining cancer prognosis in patients are crucial to controlling the suffering and death due to cancer. Cancer prediction models provide an important approach to assessing risk and prognosis by identifying individuals at high risk, facilitating the design and planning of ...

In 271 Enterobacter blood culture isolates from 12 hospitals, extended-spectrum beta-lactamase (ESBL) prevalence varied between 0% and 30% per hospital. High prevalence was associated with dissemination, indicating the potential relevance of infection control measures. Screening with cefepime or Vitek 2, followed by a cefepime/cefepime-clavulanate Etest, was an accurate ...

During the past two decades, the Child Psychiatry Branch at the National Institute of Mental Health has conducted a longitudinal study (including long-term prospective follow-up) of childhood-onset schizophrenia, a rare form of the disorder. Critical to this research has been accurate diagnosis. Outpatient screening has accurately diagnosed 55% of the 121 ...

Assessing liver damage in basic toxicology research and in preclinical toxicity testing is usually evaluated by serum biochemical parameters prior to confirmation by histopathology. With the advent of newer methods such as genomics and proteomics, there is increased enthusiasm to generate "novel" predictive markers to detect liver pathology even before the alterations in ...

BACKGROUND: Acute upper gastrointestinal hemorrhage (UGIH) is a common reason for hospitalization with substantial associated morbidity, mortality, and cost. Differentiation of high- and low-risk patients using established risk scoring systems has been advocated. The aim of this study was to determine whether these scoring systems are more accurate than an emergency ...

The genetic heterogeneity of cancer influences the trajectory of tumor progression and may underlie clinical variation in therapy response. To model such heterogeneity, we produced genetically and pathologically accurate mouse models of common forms of human acute myeloid leukemia (AML) and developed methods to mimic standard induction chemotherapy and ...

Malignant melanoma presents a substantial clinical challenge. Current diagnostic methods are limited in their ability to diagnose early disease and accurately predict individual risk of disease progression and outcome. The lack of adequate approaches to properly define disease subgroups precludes rational treatment design and ...

Entorhinal cortex (EC) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by Alzheimer�s Disease (AD). Accurate localization of EC would thus greatly facilitate early detection and diagnosis of AD. In this study, we used ultra-high resolution ex vivo MRI to directly visualize the ...

The objective of the present study was to perform biaxial testing and apply constitutive modeling to develop a strain energy function that accurately predicts the material behavior of the aortic valve leaflets. Ten leaflets from seven normal porcine aortic valves were biaxially stretched in a variety of protocols and the data combined to develop and fit a ...

Estrogen receptor (ER) positive primary breast cancers have a wide range of clinical outcomes. Prediction of the likely course of the disease aids treatment decision-making. In the translational arm of the ATAC (anastrozole or tamoxifen alone or combined) trial (TransATAC) we have assessed individual and multiparameter biomarkers for their ...

OBJECTIVE: Diagnosis of prelabour rupture of membranes (PROM) may be challenging. Conventional diagnostic methods such as speculum examination, ferning pattern, and pH detection are not satisfactorily accurate. Two relatively new, commercially available rapid bedside immunoassay strip tests, for placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor binding ...

OBJECTIVEInvasive candidiasis is a leading cause of infection-related morbidity and mortality in extremely low-birth-weight (<1000 g) infants. We quantify risk factors predicting infection in high-risk premature infants and compare clinical judgment with a prediction model of invasive candidiasis.METHODSThe study involved a ...

... Predictions of the California Current System via Accurate Light ... ECOSYSTEMS, OCEAN CURRENTS, CALIFORNIA, VISIBILITY, COMPUTATIONS ...

... Ecosystem Predictions of the California Current System via Accurate Light ... Descriptors : *ECOSYSTEMS, OCEAN CURRENTS, OCEAN MODELS ...

Accurate life prediction is critical to successful use of ceramic matrix composites (CMC). The tools

... Density Prediction Herman L. Ammon (Department of Chemistry and Biochemistry ... The work- horse refinement code WMIN, developed in the late ...

Assessing energy requirements is a fundamental activity in clinical dietetics practice. A study was designed to determine whether published linear regression equations were accurate for predicting resting energy expenditure (REE) in fasted Hispanic children with obesity (aged 7 to 15 years). REE was measured using indirect calorimetry; ...

... AWARENESS, SCORING, NURSING, CLINICAL MEDICINE, TRAINING, PREDICTIONS, ANESTHESIOLOGISTS, MILITARY OPERATIONS ...

Several studies confirm that viral load testing can accurately predict how quickly HIV-positive patients will progress to AIDS, although more clinical research is needed before clinicians can confidently use the test to determine the course of treatment. In a study presented at the Third Conference on Retroviruses and Opportunistic ...

There is rapidly accumulating evidence that the application of machine learning classification to neuroimaging measurements may be valuable for the development of diagnostic and prognostic prediction tools in psychiatry. However, current methods do not produce a measure of the reliability of the predictions. Knowing the risk of the error associated with a ...

Measures used in the selection of international dental students to a U.S. D.D.S. program were examined to identify the grouping that most effectively and efficiently predicted academic performance and clinical competency. Archival records from the International Dental Program (IDP) at Loma Linda University provided data on 171 students who had trained in ...

BackgroundThe aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS).MethodsWe obtained clinical data, MRI and MEP from a prospective cohort of 51 patients and 20 matched controls ...

OBJECTIVES: For many cardiac clinics, list-mode PET is impractical. Therefore, separate dynamic and ECG-gated acquisitions are needed to detect harmful stenoses, indicate affected coronary arteries, and estimate stenosis severity. However, physicians usually order gated studies only because of dose, time, and cost limitations. These gated studies are limited to detection. In ...

Background and purpose Accumulating evidence suggests that carotid plaque vulnerability can be used as a determinant of ischemic stroke risk stratification and carotid intervention. Novel markers of high-risk carotid plaque in patients are needed. Summary of review Advances in cellular and molecular pathophysiology, the demand for accurately predicting ...

Risk assessment scales are widely used to measure the risk of pressure ulcers in the clinical area. They have been subject to many validation studies; however these have focused on the predictive ability of the scales. We have conducted several studies that consider the validity of pressure ulcer risk assessment scales. We have reviewed these and revisited ...

BackgroundDiscriminating malignant breast lesions from benign ones and accurately predicting the risk of breast cancer for individual patients are critical in successful clinical decision-making. In the past, several artificial neural network (ANN) models have been developed for breast cancer risk prediction. All ...

The microdose (MD) clinical study enables to select a "better" compound for new drug candidate that shows desirable PK profiles in human. This new methodology is highly expected to streamline the drug development and to increase the success probability in the clinical trial. Since only a small amount of the test compound (less than 100 ?g) is administered, ...

The conventional criteria for evaluating genetic tests include analytic validity, clinical validity, and clinical utility. Analytical validity refers to a test's ability to measure the genotype of interest accurately and reliably. Clinical validity refers to a test's ability to detect or ...

It is often challenging for the clinician interested in cystic fibrosis (CF) to interpret molecular genetic results, and to integrate them in the diagnostic process. The limitations of genotyping technology, the choice of mutations to be tested, and the clinical context in which the test is administered can all influence how genetic information is interpreted. This paper ...

Accurate clinical documentation is necessary for healthcare organizations to achieve quality improvement and accurate payment. Physician buy-in is essential to a successful clinical documentation improvement program. The program should not focus on revenue enhancement or a particular tool, but should encourage ...

Computed tomography screening for early diagnosis of lung cancer is one of the more potentially useful strategies, aside from smoking cessation programmes, for reducing mortality and improving the current poor survival from this disease. The long-term success of lung cancer screening will be dependent upon identifying populations at sufficient risk in order to maximise the benefit-to-harm ratio of ...

Sentinel lymph node biopsy (SLNB) has been a reliable technique to accurately predict the axilla node status in women with breast cancer with clinically negative lymph nodes. Based on predictive accuracy evidence from large-scale clinical trials, SLNB has become the current standard of care in ...

Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health ...

Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health ...

Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health ...

Despite newer neuroimaging techniques, timely and accurate diagnosis of acute stroke remains a significant challenge. The ability to identify stroke patients rapidly using a biologic biomarker would be highly beneficial. Inflammation following stroke is one physiologic mechanism that has been studied extensively in biomarker research. Several emerging inflammatory biomarkers ...

At present, there is no gold standard test for the investigation of ovarian function in pre-menopausal breast cancer patients who develop amenorrhea after chemotherapy. Clinical, biochemical and biophysical investigations continue to be utilized in clinical practice, despite concerns regarding their predictive value for menopause. The ...

Oct 16, 2006 ... The thermochemistry of the volatilization reactions is not well characterized, preventing accurate understanding and prediction of the ...

The capability of models and theories to accurately predict and describe the behavior of low gravity

Package consisting of three separate programs used to accurately predict temperature distribution of

Sublimation of inorganic materials in the vacuum of space can be predicted accurately from knowledge

... NSLOT: Optical turbulence effects on laser beam propagation can be accurately predicted using incoherent scintillometers. ...

... Descriptors : *ENERGETIC PROPERTIES, QUANTUM ... MOLECULAR DYNAMICS, CHEMICAL REACTIONS ... THRUST, QUANTUM CHEMISTRY ...

Orbit Determination. Generation of accurate reconstructed and predicted trajectories using a combination of tracking data types. ...

... TO ACCURATE FAILURE STRENGTH ESTIMATION IS THE ESTABLISHMENT OF AN ULTIMATE STRENGTH PREDICTION CURVE ...