BackgroundIn Huntington's disease (HD), an expanded CAG repeat produces characteristic striatal neurodegeneration. Interestingly, the HD CAG repeat, whose length determines age at onset, undergoes tissue-specific somatic instability, predominant in the striatum, suggesting that tissue-specific CAG length changes could modify the disease process. Therefore, understanding the ...
PubMed Central
BackgroundAlternative splicing contributes significantly to the complexity of the human transcriptome and proteome. Computational prediction of alternative splice isoforms are usually based on EST sequences that also allow to approximate the expression pattern of the related transcripts. However, the limited number of tissues represented in the EST data as well as the ...
SUMMARYWe present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scores, and without requiring known motifs or accurate ...
Tissue-specific gene expression plays a fundamental role in metazoan biology and is an important aspect of many complex diseases. Nevertheless, an organism-wide map of tissue-specific expression remains elusive due to difficulty in obtaining these data experimentally. Here, we leveraged existing whole-animal Caenorhabditis elegans microarray data representing diverse ...
BackgroundLarge-scale compilation of gene expression microarray datasets across diverse biological phenotypes provided a means of gathering a priori knowledge in the form of identification and annotation of bimodal genes in the human and mouse genomes. These switch-like genes consist of 15% of known human genes, and are enriched with genes coding for extracellular and membrane proteins. It is of ...
A major yet unresolved quest in decoding the human genome is the identification of the regulatory sequences that control the spatial and temporal expression of genes. Distant-acting transcriptional enhancers are particularly challenging to uncover since they are scattered amongst the vast non-coding portion of the genome. Evolutionary sequence constraint can facilitate the discovery of ...
Energy Citations Database
... Title : A METHODOLOGY FOR ACCURATELY PREDICTING DEMAND FOR AIRLIFT OF MILITARY CARGO TO OVERSEAS DESTINATIONS,. ...
DTIC Science & Technology
dehydrogenase) and BCKDHA (branched chain keto acid dehydro- genase E1) that cause the maple syrup urine disease, in accordance with the information in OMIM. The prediction regarding BCKDHA is further evidence
E-print Network
Twenty-two potential miRNAs from seven miRNA families were first predicted from more than 80,857 EST sequences of peach (Prunus persica). Using two specific 5' and 3' miRNA RACE (miR-RACE) PCR reactions and sequence-directed cloning, we accurately determined the precise sequences, especially both ends, of eight candidate miRNAs. The sequencing results ...
PubMed
ABSTRACT: BACKGROUND: To elucidate the molecular complications in many complex diseases, we argue for the priority to construct a model representing the normal physiological state of a cell/tissue. RESULTS: By analyzing three independent microarray datasets on normal human tissues, we established a quantitative molecular model GET, which consists of 24 tissue-specific Gene ...
BackgroundTo elucidate the molecular complications in many complex diseases, we argue for the priority to construct a model representing the normal physiological state of a cell/tissue.ResultsBy analyzing three independent microarray datasets on normal human tissues, we established a quantitative molecular model GET, which consists of 24 tissue-specific Gene Expression ...
Accurately predicting regulatory sequences and enhancers in entire genomes is an important but difficult problem, especially in large vertebrate genomes. With the advent of ChIP-seq technology, experimental detection of genome-wide EP300/CREBBP bound regions provides a powerful platform to develop predictive tools for regulatory ...
... Title : Fast and Accurate Prediction of Windborne Contaminant Plumes for Civil Defense in Cities. Descriptive Note : Conference paper. ...
... Accession Number : ADD200835. Title : An Accurate Prediction of Natural Frequencies of Laminated Plates by a Higher Order Theory. ...
SUMMARY: In vivo dynamic contrast-enhanced imaging tools provide non-invasive methods for analyzing various functional changes associated with disease initiation, progression and responses to therapy. The quantitative application of these tools has been hindered by its inability to accurately resolve and characterize targeted tissues due to spatially mixed tissue ...
Determining how transcriptional regulatory networks are encoded in the human genome is essential for understanding how cellular processes are directed. Here, we present a novel approach for systematically predicting tissue specific regulatory elements (REs) that blends genome-wide expression profiling, vertebrate genome comparisons, ...
MOTIVATION: Long non-coding RNAs (lncRNAs) resemble protein-coding mRNAs but do not encode proteins. Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally. RESULTS: We introduce an approach to predict spliced lncRNAs in vertebrate genomes combining ...
The key to weather prediction lies in accurately measuring these variables and feeding the data into numerical models that can predict changes in the ...
NASA Website
Safety factors are used in ecological risk assessments to extrapolate from the toxic responses of laboratory test species to all species representing that group in the environment. More accurate extrapolation of species responses is important. Advances in understanding the mechanistic basis for toxicological responses and identifying molecular response pathways can provide a ...
... Title: An Efficient and Accurate Method of Estimating Substrate ... This thesis presents a Z-parameter based model to predict the substrate ...
The hepatitis B virus (HBV) enhancer and the core gene promoter regulate the expression of the core and polymerase genes, as well as of the 3.5-kilobase pregenomic RNA. RNA analysis and chloramphenicol acetyltransferase gene expression by plasmids carrying the HBV enhancer linked to the heterologous beta-globin or simian virus 40 early promoter demonstrated that the HBV enhancer is 3- to 20-fold ...
Existing methods of identifying the cleavage site of the nascent polypeptide and the C-terminal residue to which the glycosylphosphatidylinositol (GPI) anchor is attached in mature GPI-anchored proteins are technically difficult and labour-intensive. We tested the hypothesis that it was possible to predict this locus using data from the cDNA-deduced amino acid sequence and ...
... Predictions of the California Current System via Accurate Light ... ECOSYSTEMS, OCEAN CURRENTS, CALIFORNIA, VISIBILITY, COMPUTATIONS ...
... Ecosystem Predictions of the California Current System via Accurate Light ... Descriptors : *ECOSYSTEMS, OCEAN CURRENTS, OCEAN MODELS ...
Accurate life prediction is critical to successful use of ceramic matrix composites (CMC). The tools
NASA Technical Reports Server (NTRS)
... Density Prediction Herman L. Ammon (Department of Chemistry and Biochemistry ... The work- horse refinement code WMIN, developed in the late ...
Oct 16, 2006 ... The thermochemistry of the volatilization reactions is not well characterized, preventing accurate understanding and prediction of the ...
... the Commando Brigade and Submarine Parachute Assistance ... accurately predict the birth of the ... modelling work primarily based on Computational ...
Accurate prediction of gust stress being out of the question because of the multiplicity of the free
The capability of models and theories to accurately predict and describe the behavior of low gravity
Package consisting of three separate programs used to accurately predict temperature distribution of
Sublimation of inorganic materials in the vacuum of space can be predicted accurately from knowledge
... NSLOT: Optical turbulence effects on laser beam propagation can be accurately predicted using incoherent scintillometers. ...
... Descriptors : *ENERGETIC PROPERTIES, QUANTUM ... MOLECULAR DYNAMICS, CHEMICAL REACTIONS ... THRUST, QUANTUM CHEMISTRY ...
Orbit Determination. Generation of accurate reconstructed and predicted trajectories using a combination of tracking data types. ...
... TO ACCURATE FAILURE STRENGTH ESTIMATION IS THE ESTABLISHMENT OF AN ULTIMATE STRENGTH PREDICTION CURVE ...
