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1
Acetaminophen particle design using chitosan and a spray-drying technique.
2005-01-01

In this study matrices were prepared from particles of poorly water-soluble drugs such as acetaminophen (Act) to determine the drug release rate from these matrix particles. The matrix particles were prepared by incorporating drugs into chitosan powder ...

PubMed

2
Tramadol and Acetaminophen

... Tramadol and Acetaminophen. Pharmacogenomic Information. Drug ... Information. Tramadol and Acetaminophen, Analgesics, CYP2D6, Clinical Pharmacology. ...

Center for Drug Evaluation (CDER)

3
FDA Drug Safety Podcast: FDA Reduces Dose of Acetaminophen in ...

... FDA Drug Safety Podcast: FDA Reduces Dose of Acetaminophen in Combination Prescription Products. Podcast Icon. ... Acetaminophen Information. -. Contact Us. ...

Center for Drug Evaluation (CDER)

4
The effect of acetaminophen nanoparticles on liver toxicity in a rat model
2010-04-07

Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced ...

PubMed Central

5
A comparison of drug loading capacity of cellactose with two ad hoc processed lactose-cellulose direct compression excipients.
2004-04-01

This study compares the drug loading capacity of Cellactose and two excipients of similar composition and similar particle size, prepared by dry granulation and extrusion-spheronization respectively. The drugs evaluated were acetaminophen and furosemide. Acetaminophen did not significantly ...

PubMed

6
Acetaminophen and Codeine: MedlinePlus Drug Information
2011-07-28

Codeine) Fioricet® with Codeine (containing Acetaminophen, Butalbital, Caffeine, Codeine) Margesic® #3 (containing Acetaminophen, Codeine) Maxiflu® (containing...

Science.gov Websites

7
Questions and Answers about Oral Prescription Acetaminophen ...

... drugs? All oral prescription products containing acetaminophen also contain an additional pain medicine (usually an opioid). There ...

Center for Drug Evaluation (CDER)

8
Tramadol: MedlinePlus Drug Information
2011-08-23

professionals that it has asked drug manufacturers to limit the strength of acetaminophen in prescription drug products, predominantly combinations of acetaminophen and...

Science.gov Websites

9
Codeine: MedlinePlus Drug Information
2011-08-23

professionals that it has asked drug manufacturers to limit the strength of acetaminophen in prescription drug products, predominantly combinations of acetaminophen and...

Science.gov Websites

10
Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification.
2011-06-28

PURPOSE: To test the hypothesis that coating particles with a highly bonding polymer is effective in improving tabletability of poorly compressible drugs. METHODS: Micronized acetaminophen (d (90)?

PubMed

11
Alcohol Tips for youngadults

is a drug. Mixing it with any other drug can be extremely dangerous. Alcohol and acetaminophen -- a common

E-print Network

12
PATTERNS OF MEDICATION USE IN THE UNITED STATES

. � Nonprescription analgesics (acetaminophen, aspirin, ibuprofen) are the most frequently used drugs, taken by 16; 19% take at least one prescription drug. � As with adults, nonprescription analgesics (acetaminophen. The three most commonly used drugs were ...

E-print Network

13
ARE FEMALES DOING WORSE IN CHILD WELFARE?

is limited to nonopioids, including drugs that are widely available (for example, acetaminophen, aspirin Nonopioid Aspirin or acetaminophen � adjuvant drug Step 1 Source: WHO 1990. Pain persists or increases Opioid for mild to moderate pain Codeine + Nonopioid Aspirin or acetaminophen � ...

E-print Network

14
Earaches in Children

... may include any of the following: Drug Alert - Acetaminophen Concentrated Infant Drops Drug makers will stop making acetaminophen concentrated infant drops. Read more . Return to top ...

MedlinePLUS

15
Drugs beginning with: Z: MedlinePlus Drug Information
2011-07-28

Bisoprolol Zebutal® (as a combination product containing Acetaminophen, Butalbital, Caffeine) see Acetaminophen, Butalbital, and Caffeine Zegerid® (as a combination product...

Science.gov Websites

16
Drugs beginning with: Q: MedlinePlus Drug Information
2011-07-28

Quala Cet® (as a combination product containing Acetaminophen, Butalbital, Caffeine) see Acetaminophen, Butalbital, and Caffeine Qualaquin® see Quinine Quartuss® (as a...

Science.gov Websites

17
Croup and Your Child

... having problems breathing. Return to top Drug Alert - Acetaminophen Concentrated Infant Drops Drug makers will stop making acetaminophen concentrated infant drops. Read more . Return to top ...

MedlinePLUS

18
Bronchiolitis and Your Child

... do when your child has bronchiolitis: Drug Alert - Acetaminophen Concentrated Infant Drops Drug makers will stop making acetaminophen concentrated infant drops. Read more . Return to top ...

MedlinePLUS

19
In-flight Pharmacokinetics of Acetaminophen in ... - LSDA - Experiment

Apr 21, 2011 ... The objective of this study was to determine whether acetaminophen, a drug used frequently for pain relief by astronauts in space, actually ...

NASA Website

20
Effects of Anti-Inflammatory Drugs in Shock Caused by ...
1971-10-30

... at 15 min before E. coli injection. Acetaminophen (20 mg/kg) and salicylamide (50 mg/kg) were administered ... Acetaminophen ...

DTIC Science & Technology

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21
Drug-induced hepatitis

... induced hepatitis. Painkillers and fever reducers that contain acetaminophen are a common cause of liver inflammation. These ... problem. However, if you took high doses of acetaminophen, treatment should be started as soon as possible ...

MedlinePLUS

22
Acetaminophen: MedlinePlus Drug Information
2011-07-28

Why is this medication prescribed? Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches,...

Science.gov Websites

23
Effect of the mechanical activation on size reduction of crystalline acetaminophen drug particles.
2009-12-29

The decrease in particle size may offer new properties to drugs. In this study, we investigated the size reduction influence of the acetaminophen (C(8)H(9)O(2)N) particles by mechanical activation using a dry ball mill. The activated samples with the average size of 1 microm were then investigated in different time ...

PubMed

24
Effect of the mechanical activation on size reduction of crystalline acetaminophen drug particles
2009-12-29

The decrease in particle size may offer new properties to drugs. In this study, we investigated the size reduction influence of the acetaminophen (C8H9O2N) particles by mechanical activation using a dry ball mill. The activated samples with the ...

PubMed Central

25
Using Acetaminophen and Nonsteroidal Anti-inflammatory Drugs ...

... Title, Run Time, File Size, Transcript. Acetaminophen - broadcast announcement, 00:00:42, 7 KB, PDF. Acetaminophen - broadcast announcement. 00:00:37, 6 KB, PDF ...

Center for Drug Evaluation (CDER)

26
IDIOSYNCRATIC DRUG HEPATOTOXICITY INSIGHTS FROM ACETAMINOPHEN ...

NON-IMMUNE MECHANISMS OF DILI: LESSONS FROM THE ACETAMINOPHEN MOUSE MODEL Neil Kaplowitz, MD ... Effect of JNK1+2 Knockdown (antisense) on Acetaminophen Toxicity 0 ...

Center for Drug Evaluation (CDER)

27
Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.
2000-10-01

Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used antipyretic agents that most probably exert their antifever effect by inhibiting cyclooxygenase (COX)-2. Thus, COX-2-selective drugs or null mutation of the COX-2 gene reduce or prevent fever. Acetaminophen is antipyretic and analgesic, as are NSAIDs, but it lacks the ...

PubMed

28
Acetaminophen Injection: A Review of Clinical Information.
2011-09-21

ABSTRACT Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev. Five published trials directly compare acetaminophen injection to drugs available in the United States. For management of pain in adults, acetaminophen injection was at least as effective as ...

PubMed

29
Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells
1979-09-01

A reactive metabolite of acetaminophen is hepatotoxic in humans when the drug is ingested in large overdoses. The ability of the human fetal and adult liver to oxidize acetaminophen by trapping the potentially toxic metabolite as a glutathione conjugate has been measured. Oxidation by fetal liver was approximately ten times slower than ...

NASA Astrophysics Data System (ADS)

30
October 2009 Environment Health & Safety Fire &

cases, aspirin, acetaminophen, Advil (ibuprofen) or even prescription drugs are needed for pain. One

E-print Network

31
Acetaminophen modulation of hydrocodone reward in rats.
2011-05-11

Abuse of prescription opioid analgesics in non-medical context has been on the rise over the past decade. The most commonly abused analgesic in this drug class consists of a combined formulation of hydrocodone and acetaminophen. The present study was aimed to determine the rewarding effects of hydrocodone, acetaminophen, and their ...

PubMed

32
Intravenous acetaminophen.
2010-12-01

Acetaminophen has unique analgesic and antipyretic properties. It is globally recommended as a first-line agent for the treatment of fever and pain due to its few contraindications. Acetaminophen lacks the significant gastrointestinal and cardiovascular side effects associated with nonsteroidal anti-inflammatory drugs and narcotics. An ...

PubMed

33
Role of Endotoxin in the Pathogenesis of Louse-borne ...
1977-12-01

... following antibiotics can be severe and even fatal [53] the antipyretic drug acetaminophen and anti-inflammatory drug hydrocortisone were ...

DTIC Science & Technology

34
PhRMA/FDA/AASLD Drug-Induced Hepatotoxicity White ...

... analysis suggests that 50% are related to drug hepatotoxicity (acetaminophen toxicity in 32%) and Page 5. 5 ... 2 x ULN in Alkaline Phosphate OR >2 ...

Center for Drug Evaluation (CDER)

35
Over-the-Counter

... Draft, 2/21/2001. Labeling OTC Human Drug Products Updating Labeling in RLDs and ANDAs (PDF - 30KB) Example Drug Facts Labels: Acetaminophen ...

Center for Biologics Evaluation and Research (CBER)

36
May 17-18, 2011: Joint Meeting of the Nonprescription Drugs ...

... drug products containing acetaminophen should be added to the ... addition, the committees will consider adding a weight ... age-based dosing regimen for children 2 to ...

Center for Biologics Evaluation and Research (CBER)

37
Drugs beginning with: X: MedlinePlus Drug Information
2011-08-23

Injection Xifaxan® see Rifaximin Xodol® (as a combination product containing Acetaminophen, Hydrocodone) see Hydrocodone Xodol® (as a combination product containing...

Science.gov Websites

38
Drugs beginning with: U: MedlinePlus Drug Information
2011-08-23

Unisom® see Diphenhydramine Unisom SleepTabs® see Doxylamine Unisom® With Pain Relief (as a combination product containing Acetaminophen, Diphenhydramine) see...

Science.gov Websites

39
Drugs beginning with: S: MedlinePlus Drug Information
2011-08-23

Aspirin, Carisoprodol, Codeine) see Aspirin Sominex® see Diphenhydramine Sominex® Pain Relief (as a combination product containing Acetaminophen, Diphenhydramine) see...

Science.gov Websites

40
Journal of Controlled Release 69 (2000) 455�468 www.elsevier.com/locate/jconrel

release rates were investigated using theophylline and acetaminophen as model drugs. � 2000 Elsevier parameters affecting drug release. Theophylline and acetaminophen were chosen as Tablets containing 0.5% (w and acetaminophen (both using flat-faced punches (14 mm in diameter). The �from ...

E-print Network

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41
Acetaminophen: old friend--new rules.

Acetaminophen is an old and comfortable friend. In its over-the-counter forms (of which there are almost 100), it is used by millions of people for relief of pain and to treat mild fevers. When combined with an opioid as a prescription drug, it is often effective for more severe pain. Generally, for most people, when taken as directed, ...

PubMed

42
The best way to take your over-the-counter pain reliever? ...

... the-counter pain relievers/fever reducers: acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs). Acetaminophen is used to relieve headaches, muscle ...

Center for Drug Evaluation (CDER)

43
Seasonal Influenza (the Flu) during Pregnancy

... defects. Therefore, fever during pregnancy should be treated. Acetaminophen is the drug of choice for reducing fever during pregnancy. Tylenol � is one brand of acetaminophen. Being very sick from the flu may increase ...

MedlinePLUS

44
Pain medications - non narcotic: MedlinePlus Medical Encyclopedia
2011-08-30

them without a prescription from your health care provider. OTC medicines include: Acetaminophen (Tylenol) Nonsteroidal anti-inflammatory drugs (NSAIDs) Acetaminophen is called a...

Science.gov Websites

45
March 2005: Additions and Deletions to the Drug Product List

... ACETAMINOPHEN; TRAMADOL HYDROCHLORIDE TABLET; ORAL >A> ACETAMINOPHEN AND TRAMADOL HCL >A> AB KALI LABS 325MG;37.5MG N76475 001 Apr 21, 2005 Mar NEWA ULTRACET >D ...

Center for Drug Evaluation (CDER)

46
If I Had - Low Back Pain

... people�s cabinets you would start with something like acetaminophen which is very easy on the stomach, has ... of the non steroidals. You can actually use acetaminophen and the NSAIDs (non-steroidal anti-inflammatory drug) ...

MedlinePLUS

47
2009 H1N1 Flu and Pregnancy

... defects. Therefore, fever during pregnancy should be treated. Acetaminophen is the drug of choice for reducing fever during pregnancy. Tylenol � is one brand of acetaminophen. Being very sick from the flu may increase ...

MedlinePLUS

48
Molecular Structure of Acetaminophen
2004-11-09

Acetaminophen is the active ingredient in Tylenol. It is an odorless, white and crystalline powder with analgesic (pain relieving) and antipyretic (fever reducing) properties that possess a slightly bitter taste. Acetaminophen is used for the relief of fever as well as aches and pains associated with many conditions such as arthritis. However, ...

NSDL National Science Digital Library

49
Liver toxicity after acetaminophen ingestion. Inadequacy of the dose estimate as an index of risk.
1977-08-01

With increasing frequency, the physician is confronted with the problem of determining the risk of liver toxicity in a person who may have ingested an overdose of acetaminophen. To be effective, antidotal therapy must be given early after acetaminophen ingestion when the patient, despite the toxic injury occurring in his liver, may appear quite well. We ...

PubMed

50
The Ohio State University Office of Human Resources Page 1 of 3 Prescription Drug Program � Controlled Substances Guide Revised 09/01/07

Androderm Testim Striant Delatestryl Migraine Generic Name Brand Name Acetaminophen/ isometheptene Hydrocodone/ Acetaminophen Hydrocet Co-Gesic Anexsia Margesic Lorcet Norco Maxidone Zydone Xodol Stagesic Roxicodone Oxycontin ETH-Oxydose OxyIR OxyFast Oxycodone/Aspirin Edodan Percodan Oxycodone/Acetaminophen

E-print Network

51
OSU program promotes drug safety and cost control

acetaminophen, the active ingredient in Tylenol, can cause liver damage. Problems can arise when patients take contain acetaminophen (such as the painkiller Vicodin). A review of state Medicaid pharmacy claims showed high cumulative levels of acetaminophen among some patients. OSU intervened, sending letters to both

E-print Network

52
NIEHS Advances Predictive Genomics And May Help Prevent Drug-Induced Liver Injury in the Process

in being able to predict liver injury caused by acetaminophen as well as by two non- therapeutic chemical scientists (http://www.niehs.nih.gov/ of acetaminophen with very high accuracy (88.9�95.8 percent to the UNC emergency room for acetaminophen over- tive agreement. TRC was a grant-supported consortium

E-print Network

53
Int. J. Metadata, Semantics and Ontologies, Vol. 4, No. 4, 2009 277 Copyright � 2009 Inderscience Enterprises Ltd.

. Figure 1 Database examples for metadata illustration Drug Class Form Dose Acetaminophen Analgesic Capsule catalogue Patient Date Medication Dose Approval A1234 12/01/07 Acetaminophen 400 mg ZYX A9876 12.Inordertoanswertheabovequery,someknowledge missing from the written description is needed � namely, that both aspirin and ...

E-print Network

54
For personal use. Only reproduce with permission from The Lancet Publishing Group. 3 Rashid A, Khanna A, Gowar JP, Bull JP. Revised estimates of mortality

factor. If so, a comparison of users of these drugs with nonusers might mislead. Acetaminophen is a pain it depressed the use of acetaminophen. This finding about differential effects of nonsteroidal anti, ibuprofen say, and not acetaminophen. Write Z for the N�2 array of (Z si1 , Z si2 ) with the rows

E-print Network

55
Drugs CSA Schedules Medical Uses Physical Psycho

Yes 3-12 Oral, injected Hydrocodone Substance II, Product III, V Hydrocodone w/ Acetaminophen, Vicodin/ Acetaminophen, OxyContin, Endocet, Percocet, Percodan Analgesic High High Yes 3-12 Oral Codeine Substance II, Products III, V Acetaminophen, Guaifenesin or Promethazine w/Codeine, Fiorinal, Fioricet or Tylenol w

E-print Network

56
DRUGS OF ABUSE/Uses and Effects U.S. Department of Justice

/ Acetaminophen, Vicodin, Vicoprofen, Tussionex, Lortab Analgesic, Antitussive High High Yes 3-6 Oral Hydro, Oxycodone w/ Acetaminophen, OxyContin, Endocet, Percocet, Percodan Analgesic High High Yes 3-12 Oral Codeine Substance II, Products III, V Acetaminophen, Guaifenesin or Promethazine w/Codeine, Fiorinal, Fioricet

E-print Network

57
Change in pain threshold by meperidine, naproxen sodium, and acetaminophen as determined by electric pulp testing.

The purpose of this study was to compare changes in pain threshold caused by meperidine, naproxen sodium, acetaminophen, and placebo. The change in pain threshold was measured by electric pulp testing. Acetaminophen elevated the pain threshold statistically significantly. Clinically, however, the superiority of acetaminophen is ...

PubMed Central

58
http://jbx.sagepub.com/ Journal of Biomolecular Screening

acetaminophen and lactose in convective continuous mixer. & 2010 Elsevier Ltd. All rights reserved. 1-filling the feeder. The overall feed rates examined include 30 and 45 kg/h. Acetaminophen (with average particle size�425418 #12;collected are analyzed by NIR spectroscopy to determine the concentration of ...

E-print Network

59
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain.
2009-12-24

Pre-clinical evidence demonstrates that neuropathic spinal cord injury (SCI) pain is maintained by a number of neurobiological mechanisms, suggesting that treatments directed at several pain-related targets may be more advantageous compared to a treatment focused on a single target. The current study evaluated the efficacy of the non-opiate analgesic acetaminophen, which has ...

PubMed

60
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain
2009-12-24

Pre-clinical evidence demonstrates that neuropathic spinal cord injury (SCI) pain is maintained by a number of neurobiological mechanisms, suggesting that treatments directed at several pain-related targets may be more advantageous compared to a treatment focused on a single target. The current study evaluated the efficacy of the non-opiate analgesic acetaminophen, which has ...

PubMed Central

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61
Sulfinpyrazone: MedlinePlus Drug Information
2011-08-09

what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thinners') such as warfarin (Coumadin), acetaminophen (Tylenol), aspirin...

Science.gov Websites

62
Rimantadine: MedlinePlus Drug Information
2011-08-23

what prescription and nonprescription medications you are taking, especially acetaminophen, aspirin, cimetidine (Tagamet), and vitamins. tell your doctor if you have or have...

Science.gov Websites

63
Questions and Answers About Acetaminophen and Liver Injury for ...

... A: Medicines have ingredients listed on their labels. On OTC medicines, check the �Drug Facts� label under the section called Active Ingredients. ...

Center for Drug Evaluation (CDER)

64
Probenecid: MedlinePlus Drug Information
2011-08-23

or fever, ask your doctor or pharmacist to recommend an aspirin substitute, such as acetaminophen (Tylenol). tell your doctor if you have or have ever had ulcers, kidney stones, a...

Science.gov Websites

65
Oxandrolone: MedlinePlus Drug Information
2011-08-23

pharmacist if you are taking any of the following medications or herbal products: acetaminophen (Tylenol, others), cholesterol lowering medications (statins), comfrey tea, iron...

Science.gov Websites

66
Minocycline Oral: MedlinePlus Drug Information
2011-08-09

are taking or plan to take, especially acetaminophen (Tylenol, others), antacids, anticoagulants ('blood thinners') such as warfarin (Coumadin), cholesterol-lowering medications...

Science.gov Websites

67
Isometheptene, Dichloralphenazone, and Acetaminophen

... are pregnant, plan to become pregnant, or are breast-feeding. If you become ... you.remember that alcohol can add to the drowsiness caused by this drug.

MedlinePLUS

68
Interstitial nephritis: MedlinePlus Medical Encyclopedia
2011-08-30

allergic nephritis) Analgesic nephropathy Long-term use of medications such as acetaminophen (Tylenol), aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDS). This is...

Science.gov Websites

69
Generic Drugs: What Everyone Should Know

... Also, there is greater competition and less advertising, which keeps the price down. For example, in the 1950s, when the analgesic acetaminophen was developed ...

Center for Drug Evaluation (CDER)

70
FDA Drug Safety Communication: Prescription Acetaminophen Products ...

... The Toxic Exposure Surveillance System (TESS), now named the National Poison Data System (NPDS), which captures ... Brand Name, Generic Name, Dosage Form, Strength. ...

Center for Drug Evaluation (CDER)

71
Development of a Computerized Adverse Drug Event (ADE) ...
2011-05-13

... Another example is the use of two medications together, such as two currently active orders for agents that contain acetaminophen, that may result ...

DTIC Science & Technology

72
Acetaminophen, Butalbital, and Caffeine

... are pregnant, plan to become pregnant, or are breast-feeding. If you become ... you.remember that alcohol can add to the drowsiness caused by this drug.

MedlinePLUS

73
Acetaminophen � Read the Label

... So follow directions carefully and read the label. To learn more, call 888-INFO-FDA. That's 888-INFOFDA. A message from the Food and Drug Administration.

Center for Drug Evaluation (CDER)

74
Acetaminophen and Propoxyphene: MedlinePlus Drug Information
2011-08-23

doses. FDA concluded that the safety risks of propoxyphene outweigh its benefits for pain relief at recommended doses. FDA requested that the generic manufacturers of...

Science.gov Websites

75
Acetaminophen Injection: MedlinePlus Drug Information
2011-08-09

supplements, or herbal products you are taking or plan to take. Be sure to mention anticoagulants ('blood thinners') such as warfarin (Coumadin); disulfiram (Antabuse); and...

Science.gov Websites

76
A Methods Validation Protocol for Estimating ... - LSDA - Experiment

Apr 21, 2011... microbial proliferation and absorption of a marker drug, acetaminophen, .... Intestinal transit time (ITT) Total GI transit time (GITT) ...

NASA Website

77
.'--

Page 1. 18736651\\ !II Drug Facts Active ingredient (in each 0.8 mL) Acetaminophen 80 mg Feverreducer/pain reliever Uses temporarily ...

Center for Biologics Evaluation and Research (CBER)

78
Electroanalytical determination of acetaminophen using nano-TiO(2)/polymer coated electrode in the presence of dopamine.
2008-05-04

We report a new method for selective determination of acetaminophen (AP) in physiological condition. A new hybrid film modified electrode was fabricated using inorganic semiconducting nano-TiO(2) particles and redox active polymer. Redox polymer, poly(acid yellow 9) (PAY) was electrochemically deposited onto nano-TiO(2) coated glassy carbon (GC) electrode. ...

PubMed

79
In-process crystallization of acidic drugs in acrylic microparticle systems: influence of physical factors and drug-polymer interactions.
2011-04-15

Emulsion-solvent evaporation is an established method to fabricate amorphous drug-loaded microparticles. In some cases, however, the encapsulated drug is present in its crystalline form, which can affect drug release and negatively impact on other characteristics of the final product. This work aimed to investigate the factors that are ...

PubMed

80
Effects of rotation rate, mixing angle, and cohesion in two continuous powder mixers-A statistical approach

deposition (wind suspension of soil particles and dust). By using Galaxolide� and acetaminophen as chemical

E-print Network

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81
Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs.
2007-11-23

It was evaluated if coprocessing via spray drying can be used as a formulation platform to improve the compactability of formulations containing drug substance (acetaminophen, ibuprofen, cimetidine) and excipients (carbohydrates, disintegrant, glidant, surfactant). Experimental design was applied to optimise the drug concentration and ...

PubMed

82
Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method.
2001-02-01

To decrease the sensation of roughness when a tablet, which is rapidly disintegrated by saliva (rapidly disintegrating tablet), is orally taken, we prepared rapidly disintegrating tablets using microcrystalline cellulose (Avicel PH-M series), a new type of pharmaceutical excipient that is spherical and has a very small particle size (particle size, 7-32 ...

PubMed

83
The effects of formulation factors on the moist granulation technique for controlled-release tablets.
2001-10-01

Controlled-release tablets were prepared by the moist granulation technique (MGT), a granulating method that uses very limited amounts of liquid and requires microcrystalline cellulose (MCC) to absorb moisture. Acetaminophen (APAP) was the model drug, and the polymer hydroxypropylcellulose (HPC) served as the controlled-release agent. The effects of ...

PubMed

84
Process optimization for continuous extrusion wet granulation.
2010-04-06

Three granulating binders in high drug-load acetaminophen blends were evaluated using high shear granulation and extrusion granulation. A polymethacrylate binder enhanced tablet tensile strength with rapid disintegration in simulated gastric fluid, whereas polyvinylpyrrolidone and hydroxypropyl cellulose binders produced less desirable tablets. Using the ...

PubMed

85
Hydroxyapatite crystallization in the presence of acetaminophen
2006-05-01

The effect of acetaminophen; a widely used analgesic and fever reducing medicine; in supersaturated solutions of calcium phosphate was investigated under plethostatic conditions, at 37 �C, 0.15 M NaCl, pH 7.40. The rates of crystal growth measured in the presence of acetaminophen 1.654�10?4 mol dm?3 to 6.616�10?4 mol dm?3 were reduced by 43% to 79%, ...

NASA Astrophysics Data System (ADS)

86
May 17-18, 2011: Joint Meeting of the Nonprescription Drugs ...

... body), safety and efficacy data, and discuss whether new dosing information for oral over-the-counter (OTC) drug products containing acetaminophen should be ...

Center for Biologics Evaluation and Research (CBER)

87
Classifying the Semantic Relations in Noun Compounds via a Domain-Specific Lexical Hierarchy

-labeled long-term study of the effi- cacy, safety, and tolerability of subcuta- neous sumatriptan in acute transplantation, kidney transplant, drug delivery Misuse 11 drug abuse, acetaminophen overdose, ergotamine abuser

E-print Network

88
Hot air coating technique as a novel method to produce microparticles.
2004-01-01

In this work a new technology to produce microparticles, as well as the equipment suitable for its application, is described. This technique, called hot air coating (HAC), was developed to overcome the drawbacks of the conventional spray-congealing technique and consists of a special venturimeter, deliberately designed to prevent any hindrance along the axial path through which the powder is ...

PubMed

89
Acetaminophen: a practical pharmacologic overview.
1984-07-01

Acetaminophen is an effective analgesic and antipyretic agent with few adverse effects when used in recommended dosages. The drug is metabolized mainly in the liver, and the several end products have no harmful effects. An intermediate compound in a minor metabolic pathway, however, is toxic; it is normally inactivated by glutathione. In the case of an ...

PubMed Central

90
Warfarin and acetaminophen interaction: a summary of the evidence and biological plausibility.
2011-09-12

Acetaminophen is used worldwide as an analgesic and antipyretic. Part of the class of drugs known as "aniline analgesics," it is the only such drug still in use today. Because aspirin and other non-steroidal anti-inflammatory drugs inhibit platelet function and can cause injury to the gastric mucosa, ...

PubMed

91
Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique.
2006-11-01

We prepared composite particles of acetaminophen (Act) with chitosan (Cht) and hydroxypropylmethylcellulose phthalate (HPMCP) as a carrier using a newly developed 4-fluid nozzle spray-dryer. Cht dissolves in acid solutions and forms a gel, but it is insoluble in alkaline solutions. On the other hand, HPMCP is insoluble in acid solutions, but it dissolves ...

PubMed

92
Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen.
2011-02-01

While acetaminophen overdose has been recognized as a cause of alanine aminotransferase (ALT) elevations for over 40 years, recent studies have reported asymptomatic ALT elevations in research subjects who are administered with therapeutic doses (4 g/d or less) of acetaminophen for more than 4 days. While the clinical course of these elevations is not ...

PubMed

93
Acetaminophen Liver Injury
1985-11-01

Acetaminophen can produce potentially fatal liver necrosis, via an intermediate toxic metabolite. Hepatic injury usually requires acute ingestion of at least 10-15 g of the drug. The patient typically feels well for one to three days before evidence of liver damage appears. Striking elevation of aminotransferases is characteristic, reflecting acute ...

PubMed Central

94
Spectrophotometric analysis of mixtures of acetaminophen, salicylamide, and codeine phosphate in tablets.

A simple and accurate spectrophotometric procedure for the analysis of a mixture of acetaminophen, salicylamide, and codeine phosphate is described. Determination of the first 2 components depends on pH-induced differential spectral changes of their nitroso derivatives. The third component is assayed by the acid dye method. The proposed procedure was successfully applied to ...

PubMed

95
High resolution proton nuclear magnetic resonance approach to the study of hepatocyte and drug metabolism. Application to acetaminophen
1985-06-01

/sub 1/H spin echo NMR spectra of intact hepatocytes, isolated from rat liver, showed resonances for glucose, mobile fatty acids, and +N(CH/sub 3/)/sub 3/ groups including choline headgroups of phosphoglycerides. Spectra from extracts of the same cells contained many more well resolved resonances due to low Mr metabolites. These included signals for free amino acids, ketone bodies, glucose, ...

Energy Citations Database

96
Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial
2010-01-01

BackgroundAcetaminophen is often used with a non-steriodal anti-inflammatory drug for acute pain. Hitherto, these drugs have had to be given separately, typically at different time intervals. Maxigesic tablets combine acetaminophen and ibuprofen in clinically appropriate doses to simplify ...

PubMed Central

97
Effects of nifedipine, verapamil, diltiazem and trifluoperazine on the antinociceptive activity of acetaminophen.
2000-12-01

The influence of the calcium channel blockers (CCBs) nifedipine, verapamil and diltiazem, and the calmodulin antagonist trifluoperazine on the antinociceptive activity of acetaminophen was studied in male albino mice. The nociceptive response was determined by the acetic acid writhing test. Nifedipine (50 or 20 mg/kg), verapamil (20 mg/kg), diltiazem (70 mg/kg) and ...

PubMed

98
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
1983-04-01

N-Acetylcysteine is the drug of choice for the treatment of an acetaminophen overdose. It is thought to provide cysteine for glutathione synthesis and possibly to form an adduct directly with the toxic metabolite of acetaminophen, N-acetyl-p-benzoquinoneimine. However, these hypothese have not been tested in vivo, and other mechanisms ...

PubMed

99
Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats.
1976-06-01

The dose- and time-related hepatotoxic effects of acetaminophen were investigated in rats using biochemical parameters as indices of hepatotoxicity supplemented by the histopathological examination of the livers. The acute or subacute (twice daily for 7 days) administration of 0.25 g/kg acetaminophen did not produce any noticeable hepatocellular damage. On ...

PubMed

100
Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein
2004-07-27

Acetaminophen is a widely used antipyretic analgesic, reducing fever caused by bacterial and viral infections and by clinical trauma such as cancer or stroke. In rare cases in humans, e.g., in febrile children or HIV or stroke patients, acetaminophen causes hypothermia while therapeutic blood levels of the drug are maintained. In ...

PubMed Central

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101
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations.
2009-12-05

The heme peroxidase enzyme myeloperoxidase (MPO) is released by activated neutrophils and monocytes, where it uses hydrogen peroxide (H(2)O(2)) to catalyze the production of the potent oxidants hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN) from halide and pseudohalide (SCN(-)) ions. These oxidants have been implicated as key mediators of tissue damage in many ...

PubMed

102
pharmacoepidemiology and drug safety 2003; 12: 1�8 Published online in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/pds.764

wipes, Tylenol/ acetaminophen or other analgesic, saline solution, tape, burn ointment, tweezers, small

E-print Network

103
Treatment Options for Roator Cuff Tears: A Guide for Adults

... Jul. 5, 2010 Appendixes Jul. 5, 2010 Related Products for this Topic Disposition of Comments Report Oct. ... These medicines may include either acetaminophen or �nonsteroidal anti-inflammatory drugs� (also called �NSAIDs�), such as ibuprofen ...

MedlinePLUS

104
Transurethral resection of the prostate - discharge : MedlinePlus...
2011-08-30

before taking aspirin, ibuprofen (Aleve, Motrin), naproxen (Aleve, Naprosyn), acetaminophen (Tylenol), or drugs like these. You may take showers. If you have a catheter, do...

Science.gov Websites

105
Sulindac hepatotoxicity: a case report and review.
1985-01-01

A 44 year old female, previously on propranolol, phenytoin and phenobarbital, developed hepatotoxicity while on sulindac and acetaminophen containing analgesic. A limited review of hepatotoxicity and drug interactions of sulindac is presented. The possible mechanism of hepatotoxicity and its treatment is suggested. PMID:3903180

PubMed

106
September 2006: Additions and Deletions to the Drug Product List

... AND DIHYDROCODEINE BITATRATE >A> AB WEST WARD 712.8MG;60MG;32MG N40637 001 Sep 22, 2006 Sep NEWA ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE SOLUTION; ORAL >A ...

Center for Drug Evaluation (CDER)

107
Reducing Fever in Children: Safe Use of Acetaminophen

... Drug Facts label under the section called �Active Ingredient.� Get hi-res version of this photo on Flickr . Get Consumer Updates by E-mail Consumer Updates RSS Feed Share copies of this article (942 KB) On ...

MedlinePLUS

108
Prostate resection - minimally invasive - discharge: MedlinePlus...
2011-08-30

or other over-the-counter pain relievers, such as ibuprofen (Advil, Motrin), acetaminophen (Tylenol), and other drugs like these. You may take showers, but avoid baths if...

Science.gov Websites

109
Phantom limb pain: MedlinePlus Medical Encyclopedia
2011-08-30

bath -- if your surgery wound is completely healed. Ask your doctor if you can take acetaminophen (Tylenol), aspirin, ibuprofen (such as Advil or Motrin), or other drugs that can...

Science.gov Websites

110
Page 1 US FOOD AND DRUG ADMINISTRATION + + + + + AMERICAN THYROID ...

... (202) 234-4433 Page 32. Page 32 1 listing acetaminophen here. That is the No. ... (202) 234-4433 Page 56. Page 56 1 about 32 to 34 weeks gestation, and that you ...

Center for Drug Evaluation (CDER)

111
November 2008: Additions and Deletions to the Drug Product List

... 01, 2008 Nov NEWA ACETAMINOPHEN; CODEINE PHOSPHATE TABLET; ORAL CODRIX >D> @ ANDRX PHARMS 500MG;30MG N40441 001 Mar 27, 2003 Nov CAHN >A> @ WATSON LABS 500MG ...

Center for Drug Evaluation (CDER)

112
Microsoft PowerPoint - 02 Rocky Mtn June 29 2009 Ad Com ...

... Safety of Acetaminophen During Therapeutic Use Richard C. Dart, MD, PhD Director, Rocky Mountain Poison and Drug Center Denver Health and Hospital Authority ...

Center for Biologics Evaluation and Research (CBER)

113
December 2005: Additions and Deletions to the Drug Product List

... HCL AND ACETAMINOPHEN >A> AB CARACO 325MG;37.5MG N77184 001 Dec 16, 2005 Dec NEWA AMANTADINE HYDROCHLORIDE SYRUP; ORAL AMANTADINE HCL >D> AA ALPHARMA US 50MG ...

Center for Drug Evaluation (CDER)

114
Characterization of DILI Risk from Post-Marketing Reports

... related deaths; numbers & reporting rates � Clinical trial database sufficiently powered to enable ... US Crude Counts: 5 Drugs 2001-2002 2003-2004 Acetaminophen ...

Center for Drug Evaluation (CDER)

115
August 2008: Additions and Deletions to the Drug Product List

... D> AB + MIKART 650MG;50MG N89988 001 Oct 26, 1992 Aug CTEC >A> + 650MG;50MG N89988 001 Oct 26, 1992 Aug CTEC ACETAMINOPHEN; BUTALBITAL; CAFFEINE CAPSULE; ORAL ...

Center for Drug Evaluation (CDER)

116
(Man's voice) 42-seconds in-store broadcast announcement Now, an ...

Page 1. (Man's voice) 42-seconds in-store broadcast announcement Now, an important announcement regarding acetaminophen, from the Food and Drug Administration: ...

Center for Drug Evaluation (CDER)

117
Drugs of Choice for Sedation and Analgesia in the NICU
2009-03-01

SynopsisPainful procedures in the NICU are common, undertreated, and lead to adverse consequences. The most common drugs used to treat neonatal pain include the opiates, benzodiazepines, barbiturates, ketamine, propofol, acetaminophen, and local and topical anesthetics. The indications, advantages and disadvantages of the commonly used analgesic ...

PubMed Central

118
An old drug with a new purpose: cardiovascular actions of acetaminophen (paracetamol).
2005-10-01

For over 50 years, acetaminophen (paracetamol) has been a staple in industrialized and non-industrialized countries for the treatment of pain and fever. Although its precise mechanisms of action are not known, the drug generates dose-dependent reduction in circulating prostaglandins, inhibits myeloperoxidase and the oxidation of lipoproteins, and appears ...

PubMed

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