This study evaluated the potential maternal, embryotoxic and teratogenic parameters of propylene glycol monomethyl ether acetate in Sprague-Dawley rats following inhalation of vapors in days 6-15 of gestation. No teratological or other developmental effec...
National Technical Information Service (NTIS)
Three groups of 15 females rabbits were mated. Two groups were fed lead acetate in their diet at lead concentrations of 54.6 and 546 ppm from day 6 through day 16 of their gestation period. The third group of females and all males received the basal labor...
An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50, and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. ...
Energy Citations Database
Teratology studies on the following materials are provided: High aromatic solvent; Rubber solvent; Stoddard Solvent; and VM&P naphtha.
... Accession Number : ADA187495. Title : Teratology Studies on Lewisite and Sulfur Mustard Agents. Effects of Sulfur Mustard in Rats and Rabbits. ...
DTIC Science & Technology
... Accession Number : ADA198423. Title : Teratology Studies of Lewisite and Sulfur Mustard Agents: Effects of Lewisite in Rats and Rabbits. ...
Teratological test results are reported in three species of laboratory animals. Portions of these documents are not fully legible. For individual reports, see below:
A teratology test system proposed by Chernoff and Kavlock (3,4) utilizes growth and viability for 3 days after birth to prioritize chemicals for standard teratology testing. The present study is an extended observation of the growth and viability of Chern...
The purpose of the present study was to evaluate the teratogenic potential of a zineb formulation. An initial toxicity study indicated that oral doses of 1,000 or 2,000 mg/kg/day adversely affected the weight gain of nonpregnant rats but not nonpregnant mice. In the teratology st...
EPA Science Inventory
The Standard Evaluation Procedure for the Teratology Studies is a guidance document primarily intended for Agency reviewers and the regulated industry who evaluate toxicologic effects data specified in 40 CFR Part 158.124. The SEP is also intended to prov...
Toxicology and teratology studies routinely utilize animal models to determine the potential for chemical and physical agents to produce reproductive and developmental toxicity, including birth defects such as cleft palate. The standardized teratology screen typically tests co...
The evaluation of behavioral teratogenic effects in animal studies is discussed in light of the results of the Collaborative Behavioral Teratology Study (CBTS) and the U.S. EPA's guidelines for the risk assessment of suspect developmental toxicants. Although behavioral teratology...
... usage, this term refers to the study of malformations, defects, and abnormalities. Nichols (1989) defined teratology as �the study of structural abnormalities, especially monstrosities and malformations�. ...
NBII National Biological Information Infrastructure
... Pregnancy In One Of Our Studies Crohn's & Colitis Ankylosing Spondylitis Psoriasis Psoriatic Arthritis Rheumatoid Arthritis Asthma Influenza Vaccine ...
MedlinePLUS
A teratology test system proposed by Chernoff and Kavlock (3,4) utilizes growth and viability for 3 days after birth to prioritize chemicals for standard teratology testing. The present study is an extended observation of the growth and viability of Chernoff and Kavlock's animals...
Teratology, science of monsters, exists during the periods of Antiquity, Middle Ages, Renaissance, ... but its comes more precise at the XIXth century with Etienne. Geoffroy Saint Hilaire who studies several anomalies; he was interested in celosomia, cyclocephalia, anencephaly, twin monsters ... His son, Isidore Geoffroy Saint Hilaire, creates the word ...
PubMed
Studies on pre- and/or postnatal effects on mice were carried out with their identical exposure (2 mg Hg/kg body mass) to phenyl mercuric acetate or N,N'-bis-(dimethylmercury)-p-toluol-sulphonamide. Parameters of morphology, of residues, and behaviour teratology were taken into consideration. Potentiating combination effects were only ...
... Weinberg, and R. L. Brent. Teratologic studies of prenatal exposure of rats to 915 MHz microwave radiation. Radiat. ... ...
... 1998. Corticosteroids during pregnancy and oral clefts: a case-control study. Teratology 58(1):2-5. Silver RK, et ...
Post treatment brood development was normal and teratological effects were not detected at exposures
NASA Technical Reports Server (NTRS)
... Studies; Reef and Lagoon Fishes; Pelagic Fishes; Taxonomy and Teratology of Fishes; Invertebrate Embryology; Vertebrate Embryology; Reef and ...
Teratology is most simply defined as "the study of environmental agents which disturb development". A more comprehensive definition is "the study of causes, mechanisms, and manifestations of developmental deviation, structural or functional." Teratology has several important purposes. Obviously, the most important ...
In a range finding rabbit teratology study conducted at oral doses of 0, 150, 300, 450 and 600 mg/kg, reduced food consumption, ataxia, and in more severely affected animals muscle atrophy, convulsions and death were observed. The incidence of these findi...
A single generation reproduction study in rats has been completed to evaluate the toxicologic potential of 2-butanol administered via the drinking water. A teratologic phase was also incorporated in which the parent dams were rebred (2nd litters) and subj...
Ethoxylated Decyl Alcohol (CAS No. 26183-52-8) was evaluated to determine the dosage levels for a teratology study. Groups of 5 female New Zealand white rabbits were administered the test substance by gavage at dose levels of 0, 0.12, 0.25, 0.50, 0.75 and...
Preliminary, unaudited results from a dermal teratology study (in which the material was administered for 6 hours/day on gestation days 6 to 15 at 0, 10, 100, and 400 mg/kg/day) indicate a statistically significant decrease in gravid uterine weight and fe...
Potential maternal and embryotoxic effects of TBTO were evaluated in this range-finding teratology study in rabbits. TBTO was administered orally by gavage, admixed in Mazola corn oil, to seven groups of five bred New Zealand White rabbits once daily from...
Animal teratology cannot provide definitive answers to problems of human reproductive health caused by hazards of the workplace. Thus, both teratologic and epidemiologic data must be obtained and evaluated. Epidemiologic approaches to studying effects of embryonic-fetal exposure are discussed. Attention is focused on ...
... of acetic acid-acetic anhydride was observed and characterized by ... 44 Acid in Acetic Acid-Acetic Anhydride with 2 Drops Sulfuric Acid Catalyst ...
The purpose of the In Vitro Teratology Conference was to (1) reevaluate the need for and use of in vitro teratology assays, (2) examine the validation process for in tests, and (3) discuss progress in the validation of in vitro teratology screens. articipants enthusiastically sup...
... Descriptors : (*POLYMERS, SOLUTIONS(MIXTURES)), (*ACETATES, SEDIMENTATION), (*SEDIMENTATION, ACETATES), SOLUTIONS ...
... Descriptors : *POLICE, *ACETALS, *CELLULOSE ACETATES, MECHANICAL PROPERTIES, DIELECTRIC PROPERTIES, TRANSITION ...
Past studies on the toxicological effects of ethylene glycol alkyl ethers as well as the recent data on these chemicals in Japan are reviewed. Only a few researchers have participated in the study of ethylene glycol alkyl ethers in Japan. The effects of ethylene glycol alkyl ethers on testis and embryotoxic effects of ethylene glycol monomethyl ether (EGM) ...
PubMed Central
The purpose of this study was to assess the effects of Guthion, a pesticide with anticholinesterase activity, on development in rats and mice. A preliminary toxicity study with Guthion indicated that a 35 LD50 dose for virgin rats and a 10 day LD50 dose f...
Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to ...
The evaluation of behavioral teratogenic effects in animal studies is discussed in light of the results of the Collaborative Behavioral Teratology Study (CBTS) and the U.S. EPA's guidelines for the risk assessment of suspect developmental toxicants. Altho...
Attached, herewith, are copies of final reports on tan studies conducted for the International Chlorinated Paraffin Producers' Consortium. These reports are submitted in accordance with the voluntary testing agreement reached between the EPA and the conso...
