... These animals develop a spongy degeneration of the brain, as is ... has been used previously for both gene transfer therapy experiments (Klugmann ...
DTIC Science & Technology
... Motor function, myelin lipids, and brain vacuolation were analyzed in GTA-treated and untreated tremor rats. Significant ...
Genetic mutations that severely diminish the activity of aspartoacylase (ASPA) result in the fatal brain dysmyelinating disorder, Canavan disease. There is no effective treatment. ASPA produces free acetate from the concentrated brain metabolite, N-acetyl...
National Technical Information Service (NTIS)
AbstractPatients suffering from traumatic brain injury (TBI) have decreased markers of energy metabolism, including N-acetylaspartate (NAA) and ATP. In the nervous system, NAA-derived acetate provides acetyl-CoA required for myelin lipid synthesis. Acetate can also be oxidized in mitochondria for the derivation of metabolic energy. In the current study, ...
PubMed Central
This report describes a successful treatment with megestrol acetate in a child with persistent hyperinsulinemic hypoglycemia of infancy (PHHI). An 8-y-old child with PHHI treated with octreotide had marked impairment of appetite sensation and feeding skills. Within 3 wk of starting megestrol acetate (8 mg/kg/d) to stimulate her appetite, she had a ...
PubMed
... OF POROUS CELLULOSE ACETATE MEMBRANES AND A METHOD FOR IMPROVING THEIR PERFORMANCE IN REVERSE OSMOSIS,. ...
... It is made from an acetal resin called Delrin by polymerization of formaldehyde. Descriptors : *SOLID FUELS, *ACETAL ...
... Accession Number : ADD427765. Title : Development of Improved Cellulose Acetate Membranes for Reverse Osmosis. ...
... Accession Number : ADD427764. Title : Development of Improved Cellulose Acetate Membranes for Reverse Osmosis. ...
... Accession Number : ADD427763. Title : Development of Improved Cellulose Acetate Membranes for Reverse Osmosis. ...
... Accession Number : ADA304534. Title : Development of Improved Cellulose Acetate Membranes for Reverse Osmosis,. ...
... Accession Number : ADD408688. Title : Delrin Acetal Resin, Improving the Surface of Injection Moldings,. Corporate Author ...
We experienced 2 infants in whom octreotide acetate was effective on intractable chylothorax after surgery for congenital heart diseases. They were 8- and 5-month-old. They were diagnosed as having corrected transposition of the great arteries (TGA) and tetralogy of Fallot respectively, and underwent bidirectional Glenn anastomosis and right modified Blalock Taussig shunt. ...
Gene-directed enzyme prodrug therapy is a form of targeted cancer therapy, in which an enzyme is used to convert a non-toxic prodrug to a cytotoxin within the tumor. Horseradish peroxidase (HRP) is able to convert the indole prodrugs indole-3-acetic acid (IAA) and the halogenated derivative 5-bromo-IAA (5Br-IAA) to toxic agents able to ...
... OF RESULTS OF TREATMENT OF N0 2 -INDUCED PULMONARY EDEMA IN RATS WITH DESOXYCORTICOSTERONE ACETATE (DOCA) . . . . ...
Patients with primary nocturnal enuresis were entered into 4 treatment groups: observation, imipramine, desmopressin acetate or alarm therapy. Patients were weaned from therapy 6 months after inclusion in the study and were evaluated for continence at 3, 6, 9 and 12 months after beginning the study protocol. Of the 50 patients under ...
In case of non-resectable primary liver cancer the following treatment modalities can be applied: ligation, embolization or balloon occlusion of the hepatic artery, locoregional chemotherapy, percutaneous ethanol or acetic acid injection, microwave application, and cryotherapy, as well as combined therapeutic modalities. The 3-year survival rates for patients with small ...
In Japan, acetate-free biofiltration (AFBF) became commercially available in the year 2000, and these products have been reported to be clinically effective for controlling the decrease of blood pressure during dialysis or various types of dialysis intolerance. And more, acetate-free dialysis fluid was made clinically available in 2007, ...
BackgroundInterleukin 12 (IL-12), a cytokine that promotes generation of helper T cells subtype 1, is increased in multiple sclerosis. Albuterol sulfate, a ?2-adrenergic agonist, reduces IL-12 expression, so we tested the effect of albuterol as an add-on treatment to glatiramer acetate therapy.ObjectivesTo investigate the clinical and immunologic effects ...
The aim of this study was to evaluate the effects of synbiotic therapy in patients with short bowel syndrome (SBS). Four pediatric patients with SBS, who were receiving synbiotics therapy including Bifidobacterium breve, Lactobacillus casei and galactooligosaccharides, were enrolled in this study. We evaluated changes in immunonutritional parameters before ...
... Porous flat cellulose membranes were successfully regenerated from flat formamide-modified cellulose acetate membranes. ...
A method for treating hot flashes in a castrated prostatic cancer patient who is diagnosed with hot flashes warranting treatment or who is experiencing at least approximately 5 hot flashes per day is provided in which from 25 mg to 150 mg cyproterone acetate per day is orally administered to the patient. A method for improving the multidimensional quality ...
US Patent & Trademark Office Database
... Title : Improved Therapy of Leishmaniasis by Encapsulation of Antimonial Drug in Biodegradable Artificial Phospholipid Vesicles (Liposomes),. ...
Rose bengal, a xanthene derivative among the most efficient producer of singlet oxygen, was submitted to a chemical modification consisting in the introduction of an acetate group into the aromatic ring fluorophore structure. The acetate group acts as a quencher, thus inactivating both fluorescence and photosensitization properties of the molecule. In the ...
The evolving field of interventional oncology can only be considered as a small integrative part in the complex area of oncology. The new field of interventional oncology needs a standardization of the procedures, the terminology, and criteria to facilitate the effective communication of ideas and appropriate comparison between treatments and new integrative technology. In principle, ablative ...
NASA Astrophysics Data System (ADS)
... the potential occurrence of water intoxication and ... All patients receiving desmopressin acetate therapy should be ... vomiting, decreased serum sodium, weight gain ...
Center for Biologics Evaluation and Research (CBER)
Genetic mutations that severely diminish the activity of aspartoacylase (ASPA) result in the fatal brain dysmyelinating disorder, Canavan disease. There is no effective treatment. ASPA produces free acetate from the concentrated brain metabolite, N-acetylaspartate (NAA). Because acetyl coenzyme A is a key building block for lipid synthesis, we postulated that the inability to ...
The invention provides a method and regimen for treating cancer comprising administering flavone-8-acetic acid and recombinant human interleukin 2 (rIL2). According to the invention, the investigational drug, flavone-8-acetic acid, potently augments the N...
The present invention relates to an improved process for the manufacture of acetic acid and methyl acetate by carbonylation of methanol in the gas phase in the presence of catalysts containing nickel and in the presence of chlorine, bromine or iodine or v...
... Accession Number : ADD428189. Title : Improved Surface of Acetal Moldings,. Corporate Author : Personal Author(s) : Filbert ,WC ; Roder,TM. ...
Involuntary weight loss is a frequent complication of acquired immune deficiency syndrome (AIDS) and ultimately affects the majority of patients. The deleterious effects of weight loss on immune function and the physical and psychological sequelae of severe weight loss are well recognized. Megestrol acetate induces appetite stimulation and nonfluid weight gain in patients with ...
...administered orally or parenterally to animals may induce the first stage...metritis. (2) Systemic therapy with methylprednisolone acetate...corticoids, is contraindicated in animals with arrested tuberculosis...Appropriate antibacterial therapy should be instituted...
Code of Federal Regulations, 2011
The goal of postmenopausal hormone therapy is to alleviate the symptoms that are associated with the loss of estrogen. Many formulations of estrogen and progestin are available, depending on the needs and circumstances of each individual woman. For postmenopausal women, the choice of whether or not to begin therapy requires knowledge of the risks and ...
... Treatments evaluated to date include conjugated estrogens (CEE), medroxyprogesterone acetate (MPA), the combination of CEE and MPA ...
Endometrial cancer is a hormone-dependent disease and therefore an adjuvant hormonal therapy might improve the outcome in the early stages of the disease. Between 1983 and 1989, we conducted a randomised trial of 388 patients who received either medroxyprogesterone acetate (MPA) (n=133) or tamoxifen (n=121) orally for 2 years, or were ...
SUMMARYAndrogen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data supports its use in metastatic disease and in conjunction with surgery or radiation in specific settings. Alternatives to standard androgen deprivation therapy, such as intermittent androgen suppression and estrogen ...
We describe a case of an 8 year old girl with central precocious puberty. She was commenced on 3 monthly intramuscular depot Leuprorelin acetate therapy, as a result of which she developed sterile abscesses. She was converted to daily subcutaneous Leuprorelin acetate therapy with no recurrence of the abscesses. The ...
Lithographic properties of a variety of acetal-derivatized styrene based polymers are reported. The structural modifications in the polymers involve varying the size of the pendent acetal moiety. the lithographic performances of the resists containing structurally modified acetals were found to be superior to the conventional ...
A 48-year-old male was admitted to our hospital because of increasing knee pain and thigh muscle weakness. He had been undergoing hemodialysis for 15 years. His serum intact PTH value was 1,600 pg/ml with elevated ALP (387 IU/l) and osteocalcin (400 ng/ml). Ultrasound (US) examination disclosed 2 enlarged parathyroid glands. Because of poor cardiac function, an US-guided ...
