Carotid balloon test occlusion (BTO) is used to assess the collateral circulation and cerebrovascular reserve in patients in whom carotid artery occlusion is contemplated. Eight patients in whom the test was successful were evaluated with perfusion computed tomography (CT) in the resting state and after acetazolamide challenge. Three of the patients showed ...

cortex of eight rats at baseline and after acetazolamide challenge. Trigeminal nerve stimulation.49 � 0.03 mL � min-1 � mL-1 at rest, after acetazolamide challenge, and during trigeminal nerve branch of the trigeminal nerve was stimulated with two stainless steel electrodes. The cathode

We compared three-dimensional time-of-flight MR angiograms obtained before and after acetazolamide administration to evaluate whether use of this drug could improve visualization of small peripheral intracranial arteries and atherosclerotic stenosis. For evaluation of small peripheral arteries, 10 patients with clinical diagnosis of ischemic cerebrovascular disease and 10 ...

The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion. In patients with chronic steno-occlusive disease, the ability to maintain normal cerebral blood flow by reducing vascular resistance secondary to autoregulatory vasodilation is compromised. Identification of the presence and degree of ...

To evaluate changes in cerebral hemodynamics and metabolism induced by acetazolamide in healthy subjects, positron emission tomography studies for measurement of cerebral perfusion and oxygen consumption were performed. Sixteen healthy volunteers underwent positron emission tomography studies with 15O-gas and water before and after intravenous administration of ...

Embolization of a portion of the nidus of an arteriovenous malformation not only may alter hemodynamics within the nidus, but also may change blood flow dynamics in adjacent normal vessels. Sequential acetazolamide-challenge xenon CT cerebral blood flow studies were performed in eight patients before and after embolization of arteriovenous malformations to assess the ...

...2011-04-01 2011-04-01 false Sterile sodium acetazolamide. 522.44 Section 522...NEW ANIMAL DRUGS § 522.44 Sterile sodium acetazolamide. (a) Specifications. Sterile sodium acetazolamide contains...

21 Food and Drugs 6 2010-04-01...2010-04-01 false Sterile sodium acetazolamide. 522.44 ...DRUGS § 522.44 Sterile sodium acetazolamide. (a) Specifications. Sterile sodium acetazolamide contains...

... acute mountain sickness: a prospective, double-blind, randomized, ... Table 2. Effect of lectures on the understanding of acetazolamide's ( ... ...

... Title : Effect of Acetazolamide on Leg Endurance Exercise at Sea Level and Simulated Altitude. Descriptive Note : Journal article. ...

... Title : Effect of Acetazolamide on Isolated Quadriceps Muscle Endurance Performance at Sea Level and During Acute Altitude Exposure. ...

... Accession Number : ADA168074. Title : Acetazolamide and ADH, Renin, Aldosterone, and Water Electrolytes at 4100 M in Man,. ...

... Accession Number : AD0287075. Title : ADDITIVE EFFECTS OF ACETAZOLAMIDE AND FAT EMULSION ON THE AA B(CO2) DIFFERENCE. ...

A bifunctional version of PCTA (3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9,-triacetic acid) that exhibits fast complexation kinetics with the trivalent lanthanide(III) ions was synthesized in reasonable yields starting from N, N?, N?-tristosyl-(S)-2-(p-nitrobenzyl)-diethylenetriamine. pH-potentiometric studies showed that the basicities of ...

The protonation constants (K_i^H) of 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9,-triacetic acid (PCTA) and stability constants of complexes formed between this pyridine containing macrocycle and several different metal ions have been determined in 1.0 M KCl, 25�C and compared to previous literature values. ...

... frequent in porters taking acetazolamide than in the placebo group (P = .0001), but there were no serious side effects. Conclusions.�Acetazolamide was tolerable, but impractical for the ... ...

Acetazolamide increases cerebral blood flow. The generalized and regional changes in blood flow after administration of acetazolamide were evaluated by the xenon-133 inhalation technique in a series of patients with subacute or chronic focal cerebral ischemia. Acetazolamide augmented interhemispheric asymmetry of cerebral blood flow in ...

Lanthanide complexes of two tris-(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb^III complexes dimerizes in solution at low millimolar ...

Panic Control Treatment for Adolescents (PCT-A) is a developmentally sensitive and efficacious treatment for adolescents with panic disorder. The present study is a preliminary examination of the relative efficacy of individual treatment components in PCT-A in a sample of treatment completers; the study identified when rapid improvements in panic symptoms ...

A verbal protocol technique, adopted for a web usability evaluation, requires that the users are able to perform a double task: surfing and talking. Nevertheless, when blind users surf by using a screen reader and talk about the way they interact with the computer, the evaluation is influenced by a structural interference: users are forced to think aloud and listen to the screen reader at the same ...

...PCTA), in or on the following food commodities: Commodity Parts per million Collards 0.2 Kale 0.2 Mustard, greens 0.2 (d) Indirect or inadvertent residues . [Reserved] [74 FR 47456, Sept. 16,...

In the study entitled "Web usability evaluation with screen reader users: Implementation of the Partial Concurrent Thinking Aloud technique" (Federici et al. 2010), we have proposed a modified protocol of usability evaluation technique for blind users, which integrates the features of the concurrent and the retrospective techniques. This new technique, called partial concurrent thinking aloud ...

1. The net fluxes of sodium and chloride from the lumen to the blood side of isolated sheep rumen epithelium were reduced by treatment of both sides of the epithelium with acetazolamide. 2. The changes in the net fluxes of sodium and chloride were significantly correlated and showed recovery after removal of acetazolamide. 3. The net flux of potassium from ...

Pharmacologic MRI (phMRI) uses functional MRI techniques to provide a noninvasive in vivo measurement of the hemodynamic effects of drugs. The cerebral blood volume change (?CBV) serves as a surrogate for neuronal activity via neurovascular coupling mechanisms. By assessing the location and time course of brain activity in mouse mutant studies, phMRI can provide valuable insights into how ...

The aim of this study was to develop a new method for quantifying regional cerebral blood flow (rCBF) with technetium-99m ethyl cysteinate dimer (ECD) and single-photon emission tomography (SPET). Employing a three-compartment model, we introduced a parameter, regional brain fractionation index (BFI), that reflects rCBF values and is obtained by a single SPET scan at optimum time T (min) after ...

Direct revascularization has been used successfully to prevent strokes by improving regional cerebral blood flow (rCBF) to the affected hemisphere faster in patients with moyamoya disease (MMD). Since most literatures have focused on the rCBF changes of operative hemisphere, we evaluated the hemodynamics of nonoperative side by xenon-enhanced computed tomography (Xe-CT) and ...

ABSTRACT: INTRODUCTION: Acetazolamide is commonly used in chronic obstructive pulmonary disease (COPD) patients with metabolic alkalosis. Little is known of the pharmacodynamics of acetazolamide in the critically ill. We undertook a pharmacodynamic modeling of bicarbonate response to acetazolamide in COPD patients under mechanical ...

Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be important for fungal cell wall remodelling, and inhibition of these enzymes has been proposed as a potential strategy for development of novel anti-fungals. The fungal pathogen Aspergillus fumigatus possesses two distinct multi-gene chitinase families. Here we explore ...

Intraventricular haemorrhage and posthaemorrhagic ventricular dilatation remain an important challenge in the management of prematurity and are associated with significant permanent morbidity. Progressive ventricular dilatation causes white matter injury by pressure, distortion, free radical injury and inflammation. Therapeutic interventions include serial lumbar punctures, ...

Background Arterial spin labelling (ASL) is an MRI technique for measuring perfusion at the brain tissue level. The aim of the study was to investigate cerebrovascular reactivity (CVR) at brain-tissue level in patients with an internal carotid artery (ICA) occlusion by combining ASL-MRI with a vascular challenge, and determine whether the CVR varies within the perfusion ...

Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K�Cl cotransporter KCC2, a major neuronal Cl^? extruder, leads to pathologic alterations in GABA_A and glycine receptor function in the spinal cord. The ...

This investigation represents the first randomized controlled trial to evaluate the feasibility and efficacy of Panic Control Treatment for Adolescents (PCT-A). Thirteen adolescents, ages 14 to 17, were randomized to 11 weekly sessions of PCT-A treatment, whereas 13 were randomized to a self-monitoring control group. Results indicate that adolescents ...

Recent studies have suggested that cognitive impairment may be a common complication in adults with moyamoya disease (MMD). However, the mechanisms of cognitive dysfunction have not been clarified. Whether cognitive impairment may occur as a consequence of cerebral hypoperfusion and may improve after revascularization surgery has not been determined. A 39-year-old West Indian woman with subacute ...

Acetazolamide was injected into chick embryos on the 14th or 15th day of incubation. Doses ranging between 5 and 10 mg per egg produced a retardation in the growth of long bones. The affected bones contained a normal proportion of mineral as determined by ashing and presented a normal histological picture. On the basis of these findings, it is suggested that the alterations ...

A 41-year-old white woman on long-acting opioid therapy was diagnosed with moderate obstructive sleep apnea. On initiation of continuous positive airway pressure (CPAP), she manifested severe central apnea that was unresponsive to supplemental oxygen and interfered with CPAP titration. Acetazolamide, 250 mg, nightly at bedtime was initiated, and CPAP titration was repeated. On ...

We present an interventional case report of a 76-year-old man who developed bilateral angle-closure glaucoma with extensive choroidal detachment following administration of oral acetazolamide immediately after routine cataract extraction and intraocular lens implantation. Rapid clinical improvement occurred after acetazolamide was stopped and high-dose ...

Hereditary paroxysmal ataxia is a rare dominantly inherited disorder characterized by recurrent attacks of cerebellar ataxia, dysarthria, and nystagmus. Each attack lasts from several minutes to few hours or days. Usually there are no motor difficulties between attacks. We report a patient who had had recurrent ataxic episodes since early childhood. Four members of the family over two generations ...

Acetazolamide is a potent inhibitor of the reversible hydration of CO(2) catalyzed by the enzyme carbonic anhydrase and is commonly used to increase cerebral blood flow e.g. in order to estimate cerebrovascular reserve. However it is not known whether acetazolamide may positively affect the excitability of neurons in the brain in�vivo or cortical ...

... Samples of arterial blood and cerebrospinal fluid were obtained and analyzed for pH, PO2, PCO2, CO2, HCO3(-), and lactate. ...

... Diamox � ) before reaching high altitudes. For acetazolamide 250mg 2x per day (500mg total each day) is possibly ...

what prescription and nonprescription medications you are taking, especially amphetamines, aspirin, cyclosporine (Neoral, Sandimmune), medications for depression or...

Self-rated moods were determined twice daily with the Clyde Mood Scale on 35 human subjects at 200m (Baseline) during a study concerned with evaluating the efficacy of staging plus acetazolamide (treatment) for the prevention of acute mountain sickness (A...

,4 different types of diuretics, among which furosemide, a high ceiling diuretic is widely used clinically,5 Sulfanilamide S N S NH2 N H O O Sulfathiazole S NN N H SO2NH2 O Acetazolamide O SO2 NH2 NH Cl HOOC Furosemide) such as acetazolamide; diuretics, such as furosemide; matrix metalloprotease inhibitors of the sulfonylated amino acid

Male volunteers comprised two groups, one (n=7) received acetazolamide (AZ), 250 mg twice daily, a second received placebo (n=6). These subjects were reduced to 6 and 4, respectively, because of acute mountain sickness (AMS). Morning (0700-0800 AM) and ev...

Analgesic drugs like acetylsalicylic acid, paracetamol, and ibuprofen are frequently used by subjects suffering from headache of acute mountain sickness (AMS). It is not clear if the effect is due to analgesia or prevention of AMS. We performed a randomized controlled clinical trial comparing a low dose of an acetylsalicylic acid analog, calcium carbasalate (380 mg /day), to placebo in a cohort of ...

Objective To evaluate the efficacy of ginkgo biloba, acetazolamide, and their combination as prophylaxis against acute mountain sickness.Design Prospective, double blind, randomised, placebo controlled trial.Setting Approach to Mount Everest base camp in the Nepal Himalayas at 4280 m or 4358 m and study end point at 4928 m during October and November 2002.Participants 614 ...

The main objective of this study is to ascertain the effects that recycling thermoplastic PCTA (Polycyclohexylene dimethylene terephthalate, acid) has on its viscosity, one of the most important properties in injection molding. As a result of tests carried out, we are able to show that this material's viscosity follows a non-random pattern. For this analysis, we have used a ...

1. 14C-Methylthio-labelled 2-methylthio-4-ethylamino-6-tert-butylamino-sym-triazine (terbutryn), pentachlorothioanisole (PCTA), and 1,4-bis(methylthio)tetrachloro-benzene (bis-MTTCB) and their methylthio-oxidation congeners were reacted with glutathione (GSH) in the presence and absence of immobilized liver microsomal enzymes. 2. 13C-Methylthio-labelled terbutryn sulphoxide ...

A female patient presented with horizontal gaze nystagmus, mild cerebellar ataxia, recurrent headache and hemiplegia since childhood with cerebellar atrophy on magnetic resonance imaging. Genetic analysis revealed a CACNA1A gene mutation, leading to a diagnosis of familial hemiplegic migraine (FHM1). FHM is very rare, but should be considered as a differential diagnosis for childhood cerebellar ...

A diverse range of heterotrophic bacteria was screened for the presence of carbonic anhydrase (CA) activity, sensitivity to inhibition of growth by acetazolamide (CA inhibitor), and the presence of protein binding monospecific antibody prepared against purified Neisseria sicca CA. CA activity was demonstrated only in strains of N. sicca and N. gonorrhoeae. However, all ...

The role of body water metabolism on acute altitude exposure was studied. The studies were carried out in rabbits divided into four groups, namely, (i) control, (ii) exposed to acute hypoxia, (iii) exposed to acute hypoxia after treatment with 250 mg acetazolamide and (iv) exposed to acute hypoxia after treatment with 25 mg spironolactone. Total body water, extracellular ...

Purpose. To report a case of microbial keratitis caused by Pseudomonas aeruginosa treated with a combination of acetazolamide and ceftazidime. Methods. Case report. Results. We report the case of a 17-year-old contact lens-wearing female who developed severe keratitis due to Pseudomonas aeruginosa temporarily healed with topical fortified antibiotic eye drops. After few days, ...

Acetazolamide, furosemide, chlorothiazide and amiloride are pharmacologic agents that act in the proximal tubule, loop of Henle, early distal tubule and late distal tubule, respectively. These diuretic agents were used to evaluate the functional integrity...

Acetazolamide, furosemide, chlorothiazide, and amiloride are pharmacologic agents that act primarily in the proximal tubule, loop of Henle, early distal tubule and late distal tubule and collecting duct, respectively. In order to investigate the renal pat...

Acetazolamide, furosemide, chlorothiazide and amiloride are pharmacologic agents that act in the proximal tubule, loop of Henle, early distal tubule and late distal tubule, respectively. These diuretic agents were used to evaluate the functional integrity of discrete segments of ...

Exact Match  Begins With  Contains Name/Code  Property  Relationship Home | View Hierarchy | Subsets | Help Visited Concepts EVS Home NCI Metathesaurus Browser NCI Term Browser NCI Terminology Resources Term Suggestion Acetazolamide Sodium (Code C61622) Suggest

Exact Match  Begins With  Contains Name/Code  Property  Relationship Home | View Hierarchy | Subsets | Help Visited Concepts EVS Home NCI Metathesaurus Browser NCI Term Browser NCI Terminology Resources Term Suggestion Acetazolamide (Code C28809) Suggest

transporter Exogenous PAH Thazide diuretics Furosemide Bumetanide Acetazolamide Penicillin Probenecid Ascending Limb of Henle's Loop Furosemide TGF #12;Reabsorption � No solute in thin portion � 20 % of filtered

... and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial. Arch Intern Med 2005. 165:296�301. ... ...

The effects of chlorthalidone and acetazolamide on the red blood cell binding of indapamide were investigated. Both drugs caused a substantial decrease in the amount of indapamide bound to the erythrocytes in vitro. This effect was demonstrated by a change in the indapamide blood/plasma ratio from approximately 6 in control samples, to a value of 1 when either of the ...

Duodenal pouches even without Brunner's glands are able to dispose of large amounts of acid, presumably by a combination of H+ 'back diffusion' and bicarbonate secretion. This ability is a function of H+ concentration and hence H+ load. In order to study ...

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Mar 1, 2011 ... ACETAZOLAMIDE (2) [x] : AZOLES (1) [x] : ASSAYING (1) [x] : CULTURE TECHNIQUES ( 1) [x] : BIOMETRICS (1) [x] : EXTRACTION (1) [x] ...

... Thangnak (4700 m). There he developed dry, persistent cough that was aggravated by lying down. He suffered ... is widely used for treatment and prevention of acute mountain sickness due to its effect on v...

1. Acetazolamide (0.1 mM) applied to the surface of the rostral ventrolateral medulla or microinjected beneath the medullary surface in chloralose-urethane-anaesthetized, vagotomized, carotid-denervated, paralysed, servo-ventilated cats produced a long-lasting increase in integrated phrenic nerve activity. 2. Extracellular pH measured beneath the rostral ventrolateral medulla ...

Acetazolamide applied to the surface of the rostral ventrolateral medulla or microinjected beneath the medullary surface in chloralose-urethan-anesthetized, vagotomized, carotid denervated, paralyzed, servo-ventilated cats produced a long-lasting increase in phrenic minute ventilation. Extracellular pH measured beneath the rostral ventrolateral medulla exhibited a long-lasting ...

...Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED...is used in dogs as an aid in the treatment of mild congestive heart failure and for rapid reduction of intraocular...

...c) of this chapter. (c) Conditions of use. (1) It is used in dogs as an aid in the treatment of mild congestive heart failure and for rapid reduction of intraocular pressure.1 1 These conditions are NAS/NRC reviewed and deemed...

... (3) Pilocarpine 4% (37 eyes) (4) Dipivefrin 0.1% (32 eyes) argon laser trabeculoplasty (5) 250mg oral Acetazolamide (31 eyes) 32 Page 33. ...

The reduced arterial oxygen tension at high altitude impairs the ability to work. Acetazolamide improves arterial oxygen saturation (SaO(2)) by increasing ventilation but is associated with an increased work and cost of breathing. Depending on the settings, sildenafil can also increases SaO(2) possibly through a reduction in pulmonary hypertension and interstitial edema, which ...

The reduced arterial oxygen tension at high altitude impairs the ability to work. Acetazolamide improves arterial oxygen saturation (SaO₂) by increasing ventilation but is associated with an increased work and cost of breathing. Depending on the settings, sildenafil can also increases SaO₂ possibly through a reduction in pulmonary ...

Acetazolamide, a carbonic anhydrase inhibitor is used orally (no topical formulation being available in the market) for the reduction of intraocular pressure (IOP) in patients suffering from glaucoma. Two major reasons responsible for the failure to develop a topically effective formulation of acetazolamide are its low solubility (0.7mg/ml) and its low ...

Central nervous system oxygen toxicity, which occurs during diving and hyperbaric oxygen treatment, can lead to very dangerous situations, and it is of great importance to explore its mechanisms. We have speculated that cerebral blood flow plays a pivotal role in its occurrence. Except for acting as an anticonvulsant in clinical applications, acetazolamide is also a ...

Special Operation Soldiers must be prepared to work in all environmental extremes, frequently with little or no preparation time. While working in extreme heat or cold is uncomfortable, little preparation is necessary as long as reasonably fit Soldiers remain properly nourished, hydrated, or clothed. Working at high altitude poses additional risks that can be pharmacologically mitigated. While new ...

Several bifunctional chelates (BFCs) were investigated as carriers of (64)Cu for PET imaging. The most widely used chelator for (64)Cu labeling of BFCs is DOTA (1,4,7,10-tetraazacyclododecane-N,N',N?,N'''-tretraacetic acid), even though this complex exhibits only moderate in vivo stability. In this study, we prepared a series of alternative chelator-peptide conjugates labeled with (64)Cu, measured ...

Summary: The purpose of this paper was to evaluate the effects of acetazolamide on cerebral blood flow (CBF) measured by [O-15]H2O positron emission tomography (PET) during balloon test occlusion (BTO) of the internal carotid artery (ICA). [O-15]H2O PET cerebral blood flow studies were completed in 20 patients undergoing BTO CBF determinations were obtained without carotid ...

The orally administered acetazolamide has a limited use in glaucoma due to the systemic side effects associated with its use. It has been reported to show little effect on the intraocular pressure (IOP) of human and rabbit eyes upon topical application, probably owing to its poor bioavailability and instability at pH >5.0. In order to enhance the bioavailability of the ...

Aim:To determine if acetazolamide, an effective treatment for certain inherited channelopathies, has therapeutic effects on infantile nystagmus syndrome (INS) in a well-studied subject, compare them to other therapies in the same subject and to tenotomy and reattachment (T&R) in other subjects.Methods:Eye-movement data were taken using a high-speed digital video recording ...

The role of the ophthalmic artery (OA) as a collateral to the cerebral circulation in carotid occlusive disease is somewhat controversial. The aim of this study was to assess the importance of this collateral by comparing the results of transorbital Doppler ultrasonography and regional cerebral blood flow measurements using SPECT and Xenon-133 inhalation in 41 patients with unilateral high-grade ...

Abstract BACKGROUND: Many patients with obstructive sleep apnea syndrome (OSA) are unable or not willing to use CPAP therapy when traveling to the mountains for work or recreation although they risk pronounced hypoxemia and exacerbation of sleep apnea. Since the treatment of OSA at altitude has not been established we tested the hypothesis that acetazolamide improves ...

Background. The main objective of this study was to investigate the incidence and predictors of acute mountain sickness (AMS) in travelers who consulted a pre-travel clinic and the compliance with advices concerning this condition. Methods. A post-travel questionnaire was sent to clients of five travel clinics who planned to climb above 2,000 m. Results. The response was 77% and the data of all ...