Phthalic anhydride was condensed with acetoacetic ester in acetic anhydride and triethylamine solution, and when phthalyl chloride was reacted with sodium acetoacetic ester compounds were formed of the phthalide and indandione series: phthalylacetoacetic ...
National Technical Information Service (NTIS)
The role of ethanol O-d in nullifying the deuterolysis may be demonstrated by determining that transesterification of methyl acetoacetate of the ethyl ester occurs as well as deuterium exchange of the five acetoacetate hydrogens. The significant acidity of the methylene protons in the ...
ERIC Educational Resources Information Center
Search Criteria: Search Field: All > Results : All > Search Term: (Acetoacetic Acid Esters) [x]. Sort results by: NASA Center | Date Added to NTRS ...
NASA Website
Jul 5, 2007 ... Availability Options > Online [x]; Search Criteria: Search Field: All > Results : All > Search Term: (Acetoacetic Acid Esters) [x] ...
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A novel approach to the synthesis of purines bearing functionalized carbon substituents or methyl in position 6 was developed. Under different reaction conditions, 6-halopurine derivatives could react with ethyl acetoacetate efficiently to yield 2-(purin-6-yl)acetoacetic acid ethyl esters, (purin-6-yl)acetates and ...
PubMed
The formation of various alpha-diazo acetoacetic esters can be obtained in a single transformation with good to excellent yields using readily available 2-diazoacetoacetic acid. PMID:16538259
>Acid dissociation constants of some BETA -keto esters, viz. ethyl acetoacetate, ethyl alpha -phenyl acetoacetate, ethyl alpha - gamma -diphenyl acetoacetate, ethyl alpha -phenyl)phenylpropioloylacetate, ethyl alpha ( alpha -naphthyl)phenylpropioloylacetate, have been ...
Energy Citations Database
i.e., pyruvic acid, acetoacetic acid, and higher homologs. ... Abstract: ... keto acids, i.e., acetoacetic acid, levulinic acid, etc. ...
The reactions of picrylacetoacetic ester and picrylacetone with bases (alcoholates, amines, phosphine imine compounds) lead to deprotonation of the carbonyl part of the molecule. With the acetoacetic ester anion trinitrobenzene forms a stable 1:1 sigma complex at the ..cap alpha..-carbon atom.
New aliphatic polyester-type dendrimers were synthesized using a new AB2-type building block 3, prepared from benzyl acetoacetate and 2 equiv of tert-butyl acrylate by acetoacetic acid ester synthesis. The reiterative [deprotection by HCO2H, then EDCI/DMAP coupling] sequence using divergent growth method gave ...
A simple and efficient method for the preparation of ?-stereogenic ?-keto esters is described using a copper(II)-catalyzed aerobic deacylation of substituted acetoacetate esters. The substrates for the title process arise from catalytic, enantioselective conjugate additions and alkylation reactions of acetoacetate ...
Simple methods for the synthesis of 3-aryl-6-methyl-2-pyrones and 3-aryl-5-carbalkoxy-6-methyl-2-pyrones by the reaction of ethyl ..cap alpha..-formylarylacetates with acetone and acetoacetic acid esters, respectively, are proposed. Some electrophilic substitution reactions of 6-methyl-3-phenyl-2-pyrone and ...
A specific assay for 5-aminolaevulinate synthase activity is described, with a sensitivity comparable with that of radiochemical assays. It is based on measurement by g.l.c. with electron-capture detection of the pentafluorobenzyl ester of the ethyl acetoacetate pyrrole derivative of 5-aminolaevulinic acid, and of the corresponding ...
PubMed Central
We have directly tested the ability of acetoacetate, upon activation to the CoA thioester, to channel into the cholesterogenic pathway prior to scrambling of its carbon skeleton with the acetate pool. The approach relies upon trapping [3-13C]acetoacetate-derived hydroxymethylglutaryl-CoA, hydrolyzing this metabolite, and esterifying the resulting ...
ethyl acetoacetate, followed by conversion to the semicarbazone,28whose specific radioactivity after ethyl aceto- acetate and preparation of the semicarbazone. The cyanoborohydride- acetoacetic ester acetoacetate followed by preparation and recrystallization of the semicarbazone showed that
E-print Network
The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding ...
... esters of phosphorous acid, the trialkyl esters of phosphoric acid, and the alkyl esters of dialkylphosphonic acids. All the phosphonic esters tried to ...
DTIC Science & Technology
(Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids were synthesized by a new method based on the following sequence of reactions: treatment of the tert-butyl acetoacetate with sodium nitrite, alkylation of the oxime formed with an appropriate alkyl halide, halogenation of methyl alpha-keto group and simultaneous cleavage of tert-butyl ...
The review deals with the present state of the chemistry of organophosphorus compounds with an active methylene group: esters and nitriles of phosphonoacetic acids, phosphonoacetone, and other compounds in which the methylene group is linked directly to the P=O and any other electronegative group. Compounds of this type are analogues of ...
NASA Astrophysics Data System (ADS)
CONTENTS I. Introduction 27 II. 3-Chlorobut-2-enol and its ethers 28 III. 3-Chlorobut-2-enyl esters of carboxylic acids 28 IV. Condensation with aromatic hydrocarbons and related reactions 29 V. Reactions with organometallic compounds 29 VI. Syntheses based on the products of condensation of 1,3-dichlorobut-2-ene with malonic and ...
Absent among (today's) critically important biological compounds reported in carbonaceous meteorites are keto acids, i.e., pyruvic acid, acetoacetic acid, ...
... Ester 4 Dirnethyl Hexanedioic, Acid Ester (Dimethyl adipate) Ester 5 Diethyl Carbonic Acid Ester (Diethyl, Carbonate) Ester 6 Triethyl Citrate Ester 7 ...
A series of 3,5-dihydroxyheptenoic acid derivatives containing pyrazolopyridine, isoxazolopyridine, thienopyridine, and pyrazolopyrimidine as a key scaffold was synthesized from condensed pyridine and condensed pyrimidine carboxylic acid esters by homologation, aldol condensation with ethyl acetoacetate dianion, ...
Ketogenesis is usually measured in vivo by dilution of tracers of (3R)-hydroxybutyrate or acetoacetate. We show that, in perfused working rat hearts, the specific activities of (3R)-hydroxybutyrate and acetoacetate are diluted by isotopic exchanges in the absence of net ketogenesis. We call this process pseudoketogenesis. When hearts are perfused with ...
... Pesticide Reregistration Status; Organic Esters of Phosphoric Acid. Organic Esters of Phosphoric Acid. Antimicrobial Pesticide ...
EPA Pesticide Factsheets
The ester acids necessary for studyng the thermochemical properties of pyromellitic acid (PMK)-based
NASA Technical Reports Server (NTRS)
